Journal of Traditional Chinese Medicine最新文献

{"title":"MicroRNA-21 and MicroRNA-208a as Biomarkers of Myocardial Remodeling Post-Infarction","authors":"Alessandro Conti, Francesca Rinaldi","doi":"10.18081/ajbm.2026.2.82","DOIUrl":"https://doi.org/10.18081/ajbm.2026.2.82","url":null,"abstract":"Background Myocardial remodeling following acute myocardial infarction (AMI) is a critical determinant of long-term cardiac function and progression to heart failure. Conventional biomarkers provide limited insight into the molecular mechanisms underlying this process. MicroRNAs (miRNAs), particularly microRNA-21 (miR-21) and microRNA-208a (miR-208a), have emerged as potential regulators of fibrosis and myocardial injury, respectively, and may serve as novel biomarkers of post-infarction remodeling. Objective To evaluate the clinical utility of circulating miR-21 and miR-208a as biomarkers for predicting myocardial remodeling in patients following acute myocardial infarction. Methods This prospective observational study was conducted at two tertiary centers in Italy and included 60 patients with confirmed AMI and 20 healthy controls. Plasma levels of miR-21 and miR-208a were measured using quantitative real-time PCR at admission (T0), 72 hours (T1), and 3 months (T2). Echocardiographic assessment of left ventricular function and volumes was performed at baseline and 3-month follow-up. Adverse remodeling was defined as a ≥20% increase in left ventricular end-diastolic volume. Statistical analysis included correlation studies, receiver operating characteristic (ROC) curve analysis, and multivariate logistic regression. Results Both miR-21 and miR-208a levels were significantly elevated in AMI patients compared to controls (p < 0.001). MiR-21 peaked at 72 hours (5.2 ± 1.6-fold increase), while miR-208a showed highest levels at admission (4.5 ± 1.5-fold). Adverse remodeling occurred in 36.7% of patients. MiR-21 levels were significantly higher in patients with remodeling (5.9 ± 1.4 vs 3.7 ± 1.1; p < 0.001) and showed strong correlations with left ventricular ejection fraction (r = −0.62) and LVEDV (r = 0.58). MiR-208a correlated with troponin levels (r = 0.65, p < 0.001) and remodeling status (p = 0.002). ROC analysis demonstrated good predictive performance for miR-21 (AUC = 0.87) and miR-208a (AUC = 0.82), with improved accuracy when combined (AUC = 0.91). Multivariate analysis identified miR-21 and miR-208a as independent predictors of remodeling. Conclusions Circulating miR-21 and miR-208a are promising non-invasive biomarkers for assessing myocardial remodeling following AMI. MiR-21 is strongly associated with fibrotic remodeling, whereas miR-208a reflects myocardial injury severity. Their combined use enhances predictive accuracy and may support early risk stratification and personalized management of patients with post-infarction conditions. Keywords: MicroRNA-21; MicroRNA-208a; Myocardial Infarction; Cardiac Remodeling; Biomarkers; Left Ventricular Dysfunction; Fibrosis","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"14 2","pages":"82-98"},"PeriodicalIF":0.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147897648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"ASSHAN” OZIQ-OVQAT QO’SHILMASI TARKIBIDAGI VITAMINLAR MIQDORINI YuSSX METODIDA ANIQLASH","authors":"Nodira Ikromovna Ikromova","doi":"10.55475/jcgtm/vol4.iss6.2025.569","DOIUrl":"https://doi.org/10.55475/jcgtm/vol4.iss6.2025.569","url":null,"abstract":"Apelsin va greyfrut meva po`stloqlari kompozitsiyasi bo`lgan “Asshan” oziq-ovqat qo`shilmasi (OOQ) tarkibidagi suvda eruvchan vitaminlarning miqdorini yuqori samarali suyuqlik xromatografiyasi usulida aniqlash yangi OOQda C vitamini 239,175 mg/100 g miqdor bilan yetakchilik qilib, keyingi o’rinlarni B vitaminlar guruhiga mansub B2 (3.16 mg/100 g), B1 (1.095 mg/100 g) va B9 (0.74 mg/100 g) egallaganligi ko`rsatilgan. Olingan natijalarning tahlili “Asshan” OOQni zamonaviy tibbiyotda va xalq tabobatidagi yurak qon-tomir, suyak kasalliklari, kamqonlik, asab va mushak tizimlari xastaliklari, ichki organlarning yallig`lanishi kabi qator kasalliklarning profilaktikasida va davolashda qo`llash istiqbolli ekanligiga dalolat beradi.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"4 6","pages":"80-93"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.jcgtm.org/index.php/home/article/download/569/974","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“AS-MIR” O’ZIQ-OVQAT QOSHILMASINING FENOLLI BIRIKMALARI","authors":"Mirzoxidbek Muzafarjon o'g'li Bokiyev","doi":"10.55475/jcgtm/vol4.iss6.2025.551","DOIUrl":"https://doi.org/10.55475/jcgtm/vol4.iss6.2025.551","url":null,"abstract":"Quritilgan va maydalangan qizil karam (Brassica oleracea var. capitata f. rubra) o'simligining yer ustki qismi hamda yerqalampir (Armoracia rusticana) ildizini 3:1 (AS-MIR) 20 daqiqalik samarador nisbatdagi vannada 96 % li etano samaradorlik hosil qiluvchi vannada 96% xromagrafiya (YuSSX) metodi bilan aniqlandi. Xromatografik analizda tozalangan aralashmaning 100 g miqdorida 8,928 mg quertsetin, 2,973 mg apigenin, 1,373 mg rutin, 1,148 mg salitsil kislota va 1,313 mg gall kislota flavanoidlari aniqlandi.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"4 6","pages":"43-55"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.jcgtm.org/index.php/home/article/download/551/962","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETERMINATION OF VITAMIN LEVELS IN THE “AS RHEUM” FOOD SUPPLEMENT BASED ON RHUBARB AND WILD GARLIC (JUSAI) USING THE HPLC METHOD","authors":"Shakhobidin Kh. Abdullayev, Marxabo A. Xolmatova","doi":"10.55475/jcgtm/vol4.iss5.2025.568","DOIUrl":"https://doi.org/10.55475/jcgtm/vol4.iss5.2025.568","url":null,"abstract":"This article presents the results of determining the amounts of water-soluble vitamins in rhubarb leaves and the aerial part of the Allium odorum plant (jusai) growing in the Fergana Valley, as well as in a new dietary supplement (DS) “As rheum,” which is a composite mixture of these plants. Analysis by high-performance liquid chromatography (HPLC) revealed the presence of all B-group vitamins (except B12) and vitamin C. It was found that in the dietary supplement “As rheum,” the vitamin content is stabilized compared to their amounts in the original plant raw materials (rhubarb and jusai). The levels of vitamins B2, B6, and B9 in the DS “As rheum” exceed the human daily requirement by 1.95–5.08 times, indicating the potential for its effective use in traditional medicine for the prevention and treatment of conditions associated with deficiencies of these vitamins.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"4 5","pages":"29-43"},"PeriodicalIF":0.0,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.jcgtm.org/index.php/home/article/download/568/913","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ITTIKANAK O‘SIMLIGINING KIMYOVIY TARKIBI VA XALQ TABOBATIDAGI AHAMIYATI","authors":"Obidjon Shaxabidinovich Abdulloyev, Мохирахон Nodibek qizi Иномова, Maqsadbek Muydinovich Xojimatov","doi":"10.55475/jcgtm/vol4.iss4.2025.472","DOIUrl":"https://doi.org/10.55475/jcgtm/vol4.iss4.2025.472","url":null,"abstract":"Ushbu maqolada ittikanak o‘simligining kimyoviy tarkibi, botanik tavsifi va uning xalq tabobatidagi o‘rni haqida ma’lumotlar keltirilgan. Ittikanak quruq ekstrakti tarkibidagi flavanoidlar miqdori yuqori samarali suyuqlik xromatografiyasi (YuSSX) orqali aniqlandi. Olingan natijalar asosida ushbu o’simlik tarkibidagi fenol birikmalarning inson organizmdagi ahamiyati hamda teri allergik kasalliklar, diatez, psoriaz, mikroblarga qarshi ta’sirga ega ekanligi haqida ma’lumotlar keltirildi.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"4 4","pages":"173-190"},"PeriodicalIF":0.0,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WATER-SOLUBLE VITAMINS IN THE FOOD SUPPLEMENT “PROSTAFITO”","authors":"Gofurjon U Toychiev","doi":"10.55475/jcgtm/vol4.iss2.2025.510","DOIUrl":"https://doi.org/10.55475/jcgtm/vol4.iss2.2025.510","url":null,"abstract":"In this study, the amount of water-soluble vitamins (vitamin C and B-group vitamins) in selected plant samples was determined using the HPLC method. Standard vitamins and reagents from Germany and China, as well as a Shimadzu LC-40 Nexera Lite chromatograph, were used for the analysis. The samples were extracted in an HCl solution using an ultrasonic bath and separated through a special column. Each vitamin was detected at a specific wavelength, and its quantity was evaluated using a calibration curve. This method provides accurate and reliable results for vitamin determination.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"4 2","pages":"222-236"},"PeriodicalIF":0.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETERMINATION OF THE QUANTITY OF WATER-SOLUBLE VITAMINS IN ST. JOHN'S WORT FLOWERS","authors":"Ibrohimjon Rahmonovich Asqarov, Bekmirza Kholmirzaevich Tashpulatov","doi":"10.55475/jcgtm/vol4.iss2.2025.491","DOIUrl":"https://doi.org/10.55475/jcgtm/vol4.iss2.2025.491","url":null,"abstract":"Modern medicine carries out a lot of practical work on the treatment and prevention of vitiligo. The article provides brief information on the determination of some vitamins in the plant St. John's wort (Hypericum perforatum L.) using high-performance liquid chromatography and their importance in medicine, especially in the treatment of skin diseases.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"4 2","pages":"210-221"},"PeriodicalIF":0.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147918342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TUKLI ERVA O’SIMLIGINING SHIFOBAXSHLIK XUSUSIYATLARINI KIMYOVIY TARKIBI ORQALI BAHOLASH","authors":"Ibrohimjon Rahmonovich Asqarov, Obidjon Shaxabidinovich Abdulloyev, Xilolaxon G’olibjon qizi Maxmudova","doi":"10.55475/jcgtm/vol4.iss1.2025.481","DOIUrl":"https://doi.org/10.55475/jcgtm/vol4.iss1.2025.481","url":null,"abstract":"Maqolada tukli erva o’simligining kimyoviy tarkibi, uning inson salomatligi uchun ahamiyati va o’simlik spirtli ekstrakti tarkibidagi flavanoidlar miqdorini “Yuqori samarali suyuqlik xromatogafiyasi usulida tahlil qilinganligi, aniqlangan flavanoidlardan rutin, salisil kisota va quersetinlarning miqdori yuqori bo’lishi to’g’risidagi ma’lumotlar keltirilgan.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"4 1","pages":"258-273"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.jcgtm.org/index.php/home/article/download/481/717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ОПРЕДЕЛЕНИЕ ВОДОРАСТВОРИМЫХ ВИТАМИНОВ В ПЛОДАХ MACLURA POMIFERA","authors":"Roziya Nazirtashova, Shahobiddin Qirg‘izov, Ibrohimjon Rahmonovich Asqarov","doi":"10.55475/jcgtm/vol4.iss1.2025.458","DOIUrl":"https://doi.org/10.55475/jcgtm/vol4.iss1.2025.458","url":null,"abstract":"В данной статье определено и проанализировано содержание водорастворимых витаминов В плодах Maclura Pomifera, произрастающих в Узбекистане, методом ВЭЖХ. В то время как 7 различных витаминов были изучены, 100 граммов экстракта плодов Мaclura pomifera содержат B1>PP>B3>B6>B2>C>B9 в таком порядке. При этом влияние водорастворимых витаминов на здоровье человека было проанализировано и изучено на основе научных источников. Водорастворимые витамины считаются необходимыми для обмена веществ в организме, иммунной системы, здоровья глаз и кожи, костной и кровеносной систем. Водорастворимые витамины большое значение для выполнения важных функций в организме имеют витамины группы В. Водорастворимые витамины должны регулярно поступать в организм с пищей, так как их избыток не накапливается в организме. Их дефицит может привести к различным проблемам со здоровьем. Был подсчитан уровень изученности полученного растения и сделан вывод, что исследований пока недостаточно.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"4 1","pages":"337-356"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.jcgtm.org/index.php/home/article/download/458/733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the digestive and absorptive characteristics of Guizhi Decoction and its impact on drug efficacy using an in vitro intestinal culture model","authors":"Xinyao Feng, Huan Gao, Dong Bai","doi":"10.1097/gscm.0000000000000064","DOIUrl":"https://doi.org/10.1097/gscm.0000000000000064","url":null,"abstract":"Objective: To study the digestion pattern of Guizhi Decoction in various parts of the gastrointestinal tract and its efficacy based on an in vitro culture model of the intestinal tract. Methods: A rat in vitro intestinal culture model was established to simulate the digestive and absorptive processes of Guizhi Decoction in the stomach, duodenum, jejunum, ileum, cecum, and colon. High-performance liquid chromatography-mass spectrometry was used to analyze the absorption rates, permeability, and metabolic characteristics of its major components. Meanwhile, the anti-inflammatory effects of the digestion and absorption products in the exo-Taiwanese fluid of different intestinal segments were evaluated in conjunction with the LPS-induced inflammation model of RAW264.7 cells. Results: The major components of Guizhi Decoction were most effectively absorbed in the duodenum and jejunum and the colon, while the stomach and cecum showed lower absorption capacity. The permeability of cinnamic acid and liquiritigenin exceeded 100%, indicating partial conversion from other components through metabolic transformation. The cecum was identified as the primary site for the conversion of glycyrrhizic acid into glycyrrhetinic acid. The results of the pharmacodynamic experiments showed that the digestive absorption products could significantly reduce the NO concentration in the cellular supernatant under low-dose conditions, and showed good anti-inflammatory effects, especially the absorption products of the duodenum and jejunum segments had the strongest pharmacodynamic effects. Conclusions: The anti-inflammatory effect of Guizhi Decoction is mainly dependent on its digestion and absorption process in the gastrointestinal tract. The duodenum and jejunum are the main absorption sites for its pharmacologically active substances, the colon plays a significant role in reabsorption, and the cecum is crucial for metabolic transformation. This study provides a novel perspective for understanding the pharmacological basis and mechanisms of Guizhi Decoction.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 2","pages":"145-154"},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}