Effectiveness of Traditional Chinese Medicine on chemo-radiotherapy induced leukaemia in patients with lung cancer: a Meta-analysis

IF 2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine Pub Date : 2018-10-01 DOI:10.1016/S0254-6272(18)30904-X

Li Yu , Xiong Chan , Qin Erqi , Li Lin , Zhuang Guangtong , Yu Zheng

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引用次数: 7

Abstract

OBJECTIVE

To assess the curative effect of Traditional Chinese Medicine (TCM) on leukopenia induced by chemo-radiotherapy in patients with lung cancer.

METHODS

A comprehensive electronic search in Medline, Embase, the Cochrane Libary database, China National Knowledge Infrastructure Database (CNKI) and Wanfang Database was conducted up to July 2017. Random-effects model was used to estimate the standardized mean differences (SMDs) with 95% confidence intervals (CIs). Eleven studies with a total of 957 patients were included in this meta-analysis.

RESULTS

The effectiveness in TCM group was higher than control group [RR = 1.60, 95% CI (1.38, 1.85), P < 0.000 01]. Compare with Western Medicine group, the effectiveness has no significant difference [RR = 0.96, 95% CI (0.82, 1.12), P = 0.57]. The ineffective rate in test group was lower than the control group [RR = 0.30, 95% CI (0.21, 0.42), P < 0.000 01].

CONCLUSION

By meta-regression it was suggested that TCM has curative effect on leukopenia induced by chemo-radiotherapy in patients with lung cancer, but by the influence of number and quality of researches, publication bias, more evidence from high quality studies, and larger cohorts for observational trials are needed.

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中药治疗肺癌放化疗白血病疗效的meta分析

目的探讨中药治疗肺癌放化疗所致白细胞减少症的疗效。方法截至2017年7月，在Medline、Embase、Cochrane library数据库、中国知网(CNKI)和万方数据库中进行综合电子检索。采用随机效应模型估计标准化平均差(SMDs)，置信区间为95%。这项荟萃分析纳入了11项研究，共957例患者。结果中药组有效率高于对照组[RR = 1.60, 95% CI (1.38, 1.85)， P <0.000 01]。与西药组比较，疗效无显著差异[RR = 0.96, 95% CI (0.82, 1.12)， P = 0.57]。试验组无效率低于对照组[RR = 0.30, 95% CI (0.21, 0.42)， P <0.000 01]。结论经meta回归分析，中药对肺癌放化疗所致白细胞减少有疗效，但受研究数量和质量的影响，存在发表偏倚，需要更多高质量研究的证据，需要更大的观察性试验队列。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

2.40

自引率

3.80%

发文量

32269

审稿时长

2 months

期刊介绍： Journal of Traditional Chinese Medicine（JTCM） is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.