Effect of Jianpi Bushen formula on aromatase-inhibitor-associated bone loss after menopause

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Dai Yan , Chen Qingqing , Guan Ruodan , Xu Rui , Qiu Chang , Song Xue , Guo Qianqian , Wang Zhiyu , Chen Qianjun
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引用次数: 0

Abstract

OBJECTIVE

To investigate the effect of Jianpi Bushen (JPBS) formula on aromatase inhibitor (AI)-associated bone loss after menopause.

METHODS

Six-month-old female rats were randomly divided into 6 groups: a sham group, an ovariectomized (OVX) group, an OVX treated with exemestane and 3 OVX groups each treated with a different dose of JPBS formula. Bone mineral density (BMD) at the lumbar vertebrae, histology, bone markers and serum levels of estrogen were assessed. Furthermore, a cohort study was conducted in 130 postmenopausal women with breast cancer that had undergone treatment with Als. The subjects were given JPBS + caltrate D or caltrate D only, administered orally. BMD at the lumbar vertebrae and femoral neck and bone markers were evaluated in both control and herbal treatment groups at baseline and 12 months.

RESULTS

Experimental results indicated that a high dose of JPBS significantly increased the trabecular bone area percentage (Tb.Ar %) and broadened the trabecular thickness (Tb.Th). The JPBS formula enriched the carboxyterrninal propeptide of type ipmcollagen and increased serum estrogen level significantly. The clinical investigation revealed that bone loss was decreased in the group treated with JPBS vs control (BMD T score at lumbar vertebrae, 3.9% increased vs 14.58% decreased, respectively, P = 0.004 and BMD T score on femoral neck, 1.8% decreased vs 22.45% decreased, respectively, P = 0.008). Besides, JPBS formula elevated N-middle osteocalcin and decreased type I collagen cross-linked C-terminal telopeptide.

CONCLUSION

JPBS formula prevented aromatase-inhibitor-associated bone loss after menopause by inhibiting bone resorption and promoting bone formation.

健脾补肾方对绝经后芳香化酶抑制剂相关性骨丢失的影响
目的探讨健脾补肾方对绝经后芳香化酶抑制剂(AI)相关性骨质流失的影响。方法6月龄雌性大鼠随机分为6组:假手术组、去卵巢组、依西美坦治疗组和不同剂量JPBS方治疗组。评估腰椎骨密度(BMD)、组织学、骨标志物和血清雌激素水平。此外,一项队列研究对130名接受过Als治疗的绝经后乳腺癌妇女进行了研究。受试者口服JPBS +钙化D或仅钙化D。在基线和12个月时,对对照组和草药治疗组腰椎和股骨颈的骨密度和骨标志物进行评估。结果高剂量JPBS可显著提高大鼠骨小梁面积百分比(Tb)。Ar %),小梁厚度增宽(th . th)。JPBS配方丰富了ipmcollagen型羧基终端前肽,显著提高了血清雌激素水平。临床调查显示,与对照组相比,JPBS组骨量丢失减少(腰椎BMD T评分分别增加3.9%比减少14.58%,P = 0.004;股骨颈BMD T评分分别减少1.8%比22.45%,P = 0.008)。此外,JPBS配方提高了n -中骨钙素,降低了I型胶原交联c端端肽。结论jpbs配方通过抑制骨吸收和促进骨形成来预防绝经后芳香酶抑制剂相关性骨质流失。
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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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