Journal of Traditional and Complementary Medicine最新文献

{"title":"FM2- Aims & Scope","authors":"","doi":"10.1016/S2225-4110(22)00080-3","DOIUrl":"https://doi.org/10.1016/S2225-4110(22)00080-3","url":null,"abstract":"","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411022000803/pdfft?md5=00a8cbfe91cf36089b5e871b53784a4c&pid=1-s2.0-S2225411022000803-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72230010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wax apple (Syzygium samarangense) fruit extract ameliorates endothelial dysfunction and liver damage in high cholesterol diet-fed rats","authors":"Sakdina Prommaouan ,&nbsp;Nitirut Nernpermpisooth ,&nbsp;Sirinat Pengnet ,&nbsp;Tatdao Paseephol ,&nbsp;Sakara Tunsophon ,&nbsp;Wachirawadee Malakul","doi":"10.1016/j.jtcme.2022.08.002","DOIUrl":"https://doi.org/10.1016/j.jtcme.2022.08.002","url":null,"abstract":"<div><h3>Background and aim</h3><p>Wax apple fruit (<em>Syzygium samarangense</em>) is one of the most popular tropical fruit in Asia, and contains several essential nutrients. Therefore, this study explored the effects of the wax apple fruit extract on a high-cholesterol diet-induced vascular endothelial dysfunction and fatty liver in rats.</p></div><div><h3>Experimental procedure</h3><p>Male Sprague Dawley rats were fed a diet with 1.5% cholesterol (HCD) for 8 weeks, and were given wax apple fruit extract (50 and 100 mg/kg/day) orally for the last 4 weeks. After 8 weeks, blood sample, thoracic aorta, and liver were collected and processed for biochemical and histological analysis. Additionally, vascular endothelial function and the protein expression of oxidative stress markers in aortae were evaluated.</p></div><div><h3>Results and conclusion</h3><p>Wax apple reduced serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), but increased high-density lipoprotein cholesterol (HDL-C) levels. Furthermore, the liver levels of TG and TC were reduced in wax apple-treated hypercholesterolemic rats. Histological studies revealed that wax apple ameliorated HCD-induced morphologic changes of aortic and liver tissues of rats. In aortic tissues, the impaired endothelium-dependent responses to acetylcholine, the reduced nitric oxide (NO) contents, the elevated endothelin (ET)-1 contents, and the increased expression of NADPH oxidase subunit p47^phox and 4-hydroxynonenal in HCD-fed rats were reversed by wax apple treatment. These results suggest that oral administration of wax apple improves vascular dysfunction and damage in hypercholesterolemic rats possibly through increasing NO bioavailability, decreasing ET-1 levels and reducing oxidative stress. Furthermore, wax apple ameliorates the HCD-induced fatty liver in rats.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411022000578/pdfft?md5=087c91f672bff0fc569257634e4e089d&pid=1-s2.0-S2225411022000578-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72255175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trans-differentiation of mouse mesenchymal stem cells into pancreatic β-like cells by a traditional anti-diabetic medicinal herb Medicago sativa L","authors":"S. Mansourzadeh ,&nbsp;F. Esmaeili ,&nbsp;L. Shabani ,&nbsp;Sh Gharibi","doi":"10.1016/j.jtcme.2022.02.002","DOIUrl":"https://doi.org/10.1016/j.jtcme.2022.02.002","url":null,"abstract":"<div><h3>Background and aim</h3><p><em>Medicago sativa</em> L. is a medicinal herb first cultivated in ancient Iran. Traditionally, it has been utilized for the treatment of several disorders. The plant has been in the human diet for at least 1500 years. Although the hypoglycaemic and anti-diabetic effects of the plant have been approved in traditional medicine, further investigations are needed to support the rational use of <em>M. sativa</em> by humans. This project aimed to evaluate the <em>trans</em>-differentiation potential of bone marrow mesenchymal stem cells (MSCs) to pancreatic β-like cells (insulin-producing cells; IPCs) under the influence of <em>M. sativa</em> extract.</p></div><div><h3>Experimental procedure</h3><p>Bone marrow MSCs isolated, characterized, and then treated by flower or leaf extract of <em>M. sativa</em>. Beta-cell characteristics of the differentiated cells were evaluated by several techniques, including specific staining, QPCR, immunofluorescence, and ELISA.</p></div><div><h3>Results</h3><p>The results showed that the differentiated cells were able to express some specific pancreatic genes (PDX-1, insulin1, and insulin2) and proteins (insulin receptor beta, insulin, proinsulin, and C peptide). Furthermore, ELISA analysis indicated the ability of these cells in the production and secretion of insulin, after exposure to glucose.</p></div><div><h3>Conclusion</h3><p>Overall<strong>,</strong> both the flower and leaf extract of <em>M. sativa</em> had the potential of differentiation induction of MSCs into IPCs with the characteristics of pancreatic β–like cells. Therefore, <em>M. sativa</em>, as an herbal drug, may be beneficial for the treatment of diseases including diabetes.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411022000098/pdfft?md5=195ebf817d829b95cb423af3181b20db&pid=1-s2.0-S2225411022000098-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72223916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FM1 - Title Page","authors":"","doi":"10.1016/S2225-4110(22)00063-3","DOIUrl":"https://doi.org/10.1016/S2225-4110(22)00063-3","url":null,"abstract":"","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411022000633/pdfft?md5=ff2a2d8df750d5aa8e6e3a27c8bac8e8&pid=1-s2.0-S2225411022000633-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72223914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FM2- Aims & Scope","authors":"","doi":"10.1016/S2225-4110(22)00064-5","DOIUrl":"https://doi.org/10.1016/S2225-4110(22)00064-5","url":null,"abstract":"","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411022000645/pdfft?md5=bd8d7b6d3499a429fdd08b2453fbb7a9&pid=1-s2.0-S2225411022000645-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72223915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FM2- Aims & Scope","authors":"","doi":"10.1016/S2225-4110(22)00049-9","DOIUrl":"https://doi.org/10.1016/S2225-4110(22)00049-9","url":null,"abstract":"","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411022000499/pdfft?md5=89b32d8b77376ebfbae9d6677cb326e6&pid=1-s2.0-S2225411022000499-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72225309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro and In vivo antimalarial activities of Avicennia africana P. Beauv. (Avicenniaceae) ethanolic leaf extract","authors":"Mustapha A. Ahmed ,&nbsp;Elvis O. Ameyaw ,&nbsp;Francis Ackah-Armah ,&nbsp;Desmond O. Acheampong ,&nbsp;Benjamin Amoani ,&nbsp;Paulina Ampomah ,&nbsp;Emmanuel A. Adakudugu ,&nbsp;Christian K. Adokoh","doi":"10.1016/j.jtcme.2021.11.004","DOIUrl":"https://doi.org/10.1016/j.jtcme.2021.11.004","url":null,"abstract":"<div><h3>Background</h3><p>The emergence of widespread drug-resistant strains of the malaria parasites militates against strives for more potent antimalarial drugs.</p></div><div><h3>Aim</h3><p>The present study evaluated the antimalarial activity of <em>A. africana</em> ethanolic crude extract <em>in vitro</em> and <em>in vivo</em> against <em>Plasmodium</em> <em>berghei</em> -infected mice in anticipation of acquiring scientific evidence for it used by mangrove dwellers to treat malaria in Ghana.</p></div><div><h3>Methodology</h3><p>The pulverized dried leaves were extracted with 70% ethanol (v/v) and screened for phytochemicals using standard protocols. The <em>in vitro</em> antimalarial activity was investigated against chloroquine-sensitive <em>Plasmodium falciparum</em> (Pf3D7 clones), MRA-102, Lot:70032033, via SYBR® Green I fluorescent assay method using positive control Artesunate (50–1.56 × 10⁻³ μg/mL). In the i<em>n vivo</em> studies, doses (200–1500 mg/kg) of AAE were used in the 4-day suppressive and curative tests, using <em>P. berghei</em>-infected mice. Artemether/lumefantrine (1.14 mg/kg) and normal saline were used as positive and negative control respectively.</p></div><div><h3>Results</h3><p>The phytochemical analysis revealed the presence of alkaloids, saponins, flavonoids, glycosides, tannins, terpenoids and phytosterols. The extract showed an IC₅₀ of 49.30 ± 4.40 μg/mL <em>in vitro</em> and demonstrated complete parasite clearance at dose 1500 mg/kg <em>in vivo</em> with a suppressive activity of 100% (p &lt; 0.0001) in the 4-day suppressive test. The extract demonstrated high curative activity (p &lt; 0.0001) at 1500 mg/kg with 100% parasite inhibition and the oral LD₅₀ &gt; 5000 mg/kg in mice.</p></div><div><h3>Conclusion</h3><p>The results demonstrated that <em>A. africana</em> crude extract has antimalarial activity both <em>in vitro</em> and <em>in vivo</em> supporting the traditional use of the plant to treat malaria.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411021001395/pdfft?md5=a86d16223460461cd3fce16bbeda73a5&pid=1-s2.0-S2225411021001395-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72225674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of P. atlantica as a libido booster and sexual enhancer on the reproductive system of male rats","authors":"Manijeh Dogani ,&nbsp;Nayere Askari ,&nbsp;Ali Kalantari-Hesari ,&nbsp;Fatemeh Hosseini Rahbar","doi":"10.1016/j.jtcme.2021.09.007","DOIUrl":"https://doi.org/10.1016/j.jtcme.2021.09.007","url":null,"abstract":"<div><h3>Background and aim</h3><p>Alongside the advancement of various modern treatments, attention has recently been focused on finding alternative infertility treatments based on diet and herbal medicine. <em>Pistacia atlantica</em> (wild pistachio; Baneh) is a plant species traditionally known as a libido booster and sexual enhancer.</p></div><div><h3>Experimental procedure</h3><p>The study aim was to evaluate the effects of a <em>P. atlantica</em>-enriched diet on the functions of the reproductive system of male rats.</p></div><div><h3>Results and conclusion</h3><p>Results revealed that the diet containing 20% <em>P. atlantica</em> doubled testosterone levels in the treatment group compared to the control. It decreased the total bodyweight, while significantly increased the ratios of the seminal vesicles, testis, and epididymis to the bodyweight of rats. The sperm count in the treatment group was 4.8 × 10⁶/mL, which was significantly more than the control group (4.2 × 10⁶/mL). Furthermore, the utilization of <em>P. atlantica</em> significantly raised HDL levels, though it reduced the LDL and TG levels and the concentration of testis MDA. Concerning other factors, the 20% of <em>P. atlantica</em> considerably increased the serum level of Zinc and vitamin D. Histomorphometric analysis revealed that the diet increased the testicular capsule thickness, whereas it did not cause any significant change in the diameter of the seminiferous tubule, the number of Leydig cells, and Sertoli cells. Additionally, the repopulation index, tubular differentiation index, and spermiogenesis index increased in the treatment group. Molecular analysis showed that the prescribed diet increased the expression of both oxytocin (<em>OXT</em>) and its receptor (<em>OXTR</em>) genes, improving the reproductive system function.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411021001231/pdfft?md5=4a0cc0ceac7788fe3b733b1c4adedab7&pid=1-s2.0-S2225411021001231-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72225672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant-like effect of Campomanesia xanthocarpa seeds in mice: Involvement of the monoaminergic system","authors":"Gabriela Sabrina Anzollin ,&nbsp;Lilian Zaki ,&nbsp;Thalita Maria Perin ,&nbsp;Bruna Finger ,&nbsp;Letícia Trentin Perin ,&nbsp;Fernanda Petry ,&nbsp;Thalia Sebulsqui Saraiva ,&nbsp;Maria Luiza Lima da Costa Lopes ,&nbsp;Andresa Heemann Betti ,&nbsp;Jaqueline Scapinello ,&nbsp;J. Vladimir Oliveira ,&nbsp;Jacir Dal Magro ,&nbsp;Liz G. Müller","doi":"10.1016/j.jtcme.2021.08.013","DOIUrl":"https://doi.org/10.1016/j.jtcme.2021.08.013","url":null,"abstract":"<div><h3>Background and aim</h3><p><em>Campomanesia xanthocarpa</em> Berg. (Myrtaceae) present several pharmacological actions, but there are no reports on its antidepressant-like potential. This study investigated the antidepressant-like effect and mechanism of action of <em>Campomanesia xanthocarpa</em> seeds extract obtained from supercritical CO₂ (40 °C, 250 bar).</p></div><div><h3>Experimental procedure</h3><p>Mice were orally treated with the extract 1 h before the TST. To investigate the involvement of the monoaminergic system in the antidepressant-like activity of the extract, pharmacological antagonists were administered prior to the acute oral administration of the extract (60 mg/kg). Also, the interaction of the extract with antidepressants was assessed in the tail suspension test (TST). The <em>in vitro</em> inhibitory potential of <em>C. xanthocarpa</em> seeds extract towards MAO A and MAO B enzymes was tested <em>in vitro</em>.</p></div><div><h3>Results and conclusion</h3><p>Animals treated with <em>Campomanesia xanthocarpa</em> seeds extract showed a significant reduction in the immobility time in the TST. Mice pretreatment with SCH23390, sulpiride, prazosin, yohimbine, and <em>p</em>-chlorophenylalanine prevented the anti-immobility effect of the extract in the TST. The combined administration of sub-effective doses of the extract with imipramine, bupropion and fluoxetine significantly reduced mice immobility time in the TST. The extract showed MAO A inhibitory activity (IC₅₀ = 151.10 ± 5.75 μg/mL), which was greater than that toward MAO B (IC₅₀ &gt; 400 μg/mL).</p><p>The extract of <em>Campomanesia xanthocarpa</em> seeds obtained by supercritical CO₂ shows antidepressant-like activity, which relies on the activation of the monoaminergic neurotransmission (serotoninergic, dopaminergic and noradrenergic), suggesting that this species might represent a resource for developing new antidepressants.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcme.2021.08.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72225308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FM1 - Title Page","authors":"","doi":"10.1016/S2225-4110(22)00048-7","DOIUrl":"https://doi.org/10.1016/S2225-4110(22)00048-7","url":null,"abstract":"","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411022000487/pdfft?md5=83acd3e7e495b54b07ca9e93fd915126&pid=1-s2.0-S2225411022000487-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72225310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}