八子布神通过缓解骨骼肌的细胞衰老,减轻与年龄有关的肌肉萎缩

IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
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引用次数: 0

摘要

背景和目的肌肉萎缩是最常见的与年龄有关的疾病之一,其特征是骨骼肌结构退化和功能受损。它与细胞衰老和慢性炎症有关,而细胞衰老和慢性炎症会损害肌肉干细胞的功能。八子布参(BZBS)是一种专利复方中药,已被证明在多种动物模型中具有抗衰老作用。实验过程采用自然衰老小鼠(18 个月)肌肉萎缩模型,给予 BZBS(2 克/千克/天,1 克/千克/天)和烟酰胺单核苷酸(NMN,200 毫克/千克/天)。用药 6 个月后,测量肌肉重量损失、肌肉功能和肌肉组织病理学,以评估 BZBS 的治疗效果。结果和结论与年龄匹配的自然衰老小鼠相比,我们发现 BZBS 通过减少衰老细胞、炎症细胞因子和衰老肌肉组织中的肌纤维间纤维化,改善了肌肉的强度、质量和形态。我们还发现,BZBS 可防止 Pax7 阳性干细胞的减少,并刺激其活化和分化为肌细胞。我们的研究结果表明,BZBS可能是治疗老年性肌肉萎缩的一种有前景的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Bazi Bushen mitigates age-related muscular atrophy by alleviating cellular senescence of skeletal muscle

Bazi Bushen mitigates age-related muscular atrophy by alleviating cellular senescence of skeletal muscle

Background and aim

Muscular atrophy is one of the most common age-related conditions characterized by the deterioration of skeletal muscle structures and impaired functions. It is associated with cellular senescence and chronic inflammation, which impair the function of muscle stem cells. Bazi Bushen (BZBS) is a patent compound Chinese medicine that has been shown to have anti-aging effects in various animal models. In this study, we investigated the effects and mechanisms of BZBS on muscular atrophy in naturally aged mice.

Experimental procedure

A muscular atrophy model of naturally aged mice (18 months) was employed with administration of BZBS (2 g/kg/d, 1 g/kg/d) and nicotinamide mononucleotide (NMN, 200 mg/kg/d). After six months of drug administration, muscle weight loss, muscle function and muscle histopathology were measured to evaluate the therapeutic effect of BZBS. The expression of cellular senescence, inflammatory and satellite cell-related factors were used to assess the effects of BZBS in inhibiting cellular senescence, reducing inflammation and improving muscle atrophy.

Results and conclusion

Compared with age matched natural aging mice, we found that BZBS improved muscle strength, mass, and morphology by reducing senescent cells, inflammatory cytokines, and intermyofiber fibrosis in aged muscle tissues. We also found that BZBS prevented the reduction of Pax7 positive stem cells and stimulated the activation and differentiation into myocytes. Our results suggest that BZBS might be a promising intervention in senile muscular atrophy.

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来源期刊
Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine Medicine-Complementary and Alternative Medicine
CiteScore
9.30
自引率
6.70%
发文量
78
审稿时长
66 days
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