Journal of Traditional and Complementary Medicine最新文献

{"title":"Boswellic acid formulations are not suitable for treatment of pediatric high-grade glioma due to tumor promoting potential","authors":"Maria Wiese ,&nbsp;Bente Pohlmeier ,&nbsp;Klaudia Kubiak ,&nbsp;Fatma E. El-Khouly ,&nbsp;Maren Sitte ,&nbsp;Angel M. Carcaboso ,&nbsp;Joshua N. Baugh ,&nbsp;Thomas Perwein ,&nbsp;Gunther Nussbaumer ,&nbsp;Michael Karremann ,&nbsp;Gerrit H. Gielen ,&nbsp;Gabriela Salinas ,&nbsp;Christof M. Kramm","doi":"10.1016/j.jtcme.2023.07.007","DOIUrl":"10.1016/j.jtcme.2023.07.007","url":null,"abstract":"<div><h3>Background and aim</h3><p>Pediatric high-grade gliomas (pedHGG) comprise a very poor prognosis. Thus, parents of affected children are increasingly resorting to complementary and alternative medicine (CAM), among those Boswellia extracts. However, nothing is known about the therapeutic effectiveness of their active substances, Boswellic acids (BA) in pedHGG. Thus, we aimed to investigate if the three main Boswellic acids (BA) present in Boswellia plants, alpha-boswellic acid (α-BA), beta-boswellic acid (β-BA) and 3-acetyl-11-keto-beta-boswellic acid (AKBA) hold any promising potential for treatment of affected pedHGG patients.</p></div><div><h3>Experimental procedure</h3><p>Histone 3 (H3)-wildtype and H3.3K27M-mutant pedHGG cell lines were treated with BA, either alone or in combination with radio-chemotherapy with temozolomide. Cell viability, stemness properties, apoptosis, <em>in ovo</em> tumor growth and the transcriptome was investigated upon BA treatment.</p></div><div><h3>Results and conclusion</h3><p>Interestingly, α-BA and β-BA treatment promoted certain tumor properties in both pedHGG cells. AKBA treatment reduced cell viability and colony growth accompanied by induction of slight anti-inflammatory effects especially in H3.3K27M-mutant pedHGG cells. However, no effects on apoptosis and in ovo tumor growth were found. In conclusion, besides positive anti-tumor effects of AKBA, tumor promoting effects were observed upon treatment with α-BA and β-BA. Thus, only pure AKBA formulations may be used to exploit any potential positive effects in pedHGG patients. In conclusion, the use of commercially available supplements with a mixture of different BA cannot be recommended due to detrimental effects of certain BA whereas pure AKBA formulations might hold some potential as therapeutic supplement for treatment of pedHGG patients.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 101-108"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000822/pdfft?md5=05c514f2d5989c0ef6e0fbf44e63ccf9&pid=1-s2.0-S2225411023000822-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49428929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-derived natural medicines for the management of osteoporosis: A comprehensive review of clinical trials","authors":"Seyedeh Mahnaz Karimi ,&nbsp;Mohammad Bayat ,&nbsp;Roja Rahimi","doi":"10.1016/j.jtcme.2023.08.001","DOIUrl":"10.1016/j.jtcme.2023.08.001","url":null,"abstract":"<div><h3>Background</h3><p>Osteoporosis is a chronic and systemic skeletal disease that is defined by low bone mineral density (BMD) along with an increase in bone fragility and susceptibility to fracture. This study aimed to overview clinical evidence on the use of herbal medicine for management of osteoporosis.</p></div><div><h3>Methods</h3><p>Electronic databases including Pubmed, Medline, Cochrane library, and Scopus were searched until November 2022 for any clinical studies on the efficacy and/or safety of plant-derived medicines in the management of osteoporosis.</p></div><div><h3>Results</h3><p>The search yielded 57 results: 19 on single herbs, 16 on multi-component herbal preparations, and 22 on plant-derived secondary metabolites. Risk of fracture, bone alkaline phosphatase, BMD, and specific bone biomarkers are investigated outcomes in these studies. Medicinal plants including <em>Acanthopanax senticosus, Actaea racemosa, Allium cepa, Asparagus racemosus, Camellia sinensis, Cissus quadrangularis, Cornus mas, Nigella sativa, Olea europaea, Opuntia ficus-indica, Pinus pinaster, Trifolium pretense</em> and phytochemicals including isoflavones, ginsenoside, Epimedium prenyl flavonoids, tocotrienols are among plant-derived medicines clinically investigated on osteoporosis. It seems that multi-component herbal preparations were more effective than single-component ones; because of the synergistic effects of their constituents. The investigated herbal medicines demonstrated their promising results in osteoporosis via targeting different pathways in bone metabolism, including balancing osteoblasts and osteoclasts, anti-inflammatory, immunomodulatory, antioxidant, and estrogen-like functions.</p></div><div><h3>Conclusion</h3><p>It seems that plant-derived medicines have beneficial effects on bone and may manage osteoporosis by affecting different targets and pathways involved in osteoporosis; However, Future studies are needed to confirm the effectiveness and safety of these preparations.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 1-18"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000846/pdfft?md5=86b398c02d1fe496ffcb183acd0f1b76&pid=1-s2.0-S2225411023000846-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42362207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response surface methodology based development of an optimized polyherbal formulation and evaluation of its anti-diabetic and anti-obesity potential in high-fat diet-induced obese mice","authors":"Tanisha,&nbsp;Sunil Venkategowda,&nbsp;Mala Majumdar","doi":"10.1016/j.jtcme.2023.07.002","DOIUrl":"10.1016/j.jtcme.2023.07.002","url":null,"abstract":"<div><h3>Background and aim</h3><p>The seeds of <em>Nelumbo nucifera, Chenopodium quinoa</em> and <em>Salvia hispanica</em> are known as super foods due to their various therapeutic properties. The present study aimed to develop an optimized polyherbal formulation from edible seeds aqueous extract and to evaluate its anti-diabetic and lipase inhibitory effect on diet-induced obese diabetic mice.</p></div><div><h3>Experimental procedure</h3><p>Response surface methodology based various formulations were evaluated for their potent anti-diabetic, lipase-inhibitory and antioxidant activities. Acute toxicity of the best optimized formulation was conducted. The mice were fed a high fat diet for 10 weeks resulting in hyperglycemia and obesity. Oral tolerance tests (sucrose, starch and lipid) of the formulation were performed. The mice were supplemented with different doses (125, 250 and 500 mg/kg) of the formulation for 6 weeks. The body weight and blood glucose level were monitored on a weekly basis. Finally, histological alterations and lipid profiles were analysed.</p></div><div><h3>Results and conclusion</h3><p>The formulation containing equal concentration (1.5 mg/ml) of each seed extract showed maximum bioactivities. The formulation was found to be safe during toxicity assay. The tolerance tests supported the anti-diabetic and anti-obesity effect. Higher dose (500 mg/kg) of the formulation significantly (<em>p &lt;</em> 0.01) lowered elevated fasting blood glucose, lipid indices and ameliorated the histological alterations in liver, kidney and pancreas caused by high fat diet. We demonstrated for the first time that the developed aqueous extract optimized formulation possess anti-diabetic and anti-obesity potential and thus could be used as adjuvant therapy for holistic management of type 2 diabetes mellitus.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 70-81"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000779/pdfft?md5=0e8cfa4fc1ae3b20f7e40bb6763aff85&pid=1-s2.0-S2225411023000779-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43915318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-joint axis: Oral Probiotic ameliorates Osteoarthritis","authors":"Uzma Amin ,&nbsp;Rong Jiang ,&nbsp;Shahid Masood Raza ,&nbsp;Mengtian Fan ,&nbsp;Li Liang ,&nbsp;Naibo Feng ,&nbsp;Xiaoli Li ,&nbsp;Yuyou Yang ,&nbsp;Fengjin Guo","doi":"10.1016/j.jtcme.2023.06.002","DOIUrl":"10.1016/j.jtcme.2023.06.002","url":null,"abstract":"<div><p>Osteoarthritis (OA) etiology is multifactorial, and its prevalence is growing globally. The Gut microbiota shapes our immune system and impacts all aspects of health and disease. The idea of utilizing probiotics to treat different conditions prevails. Concerning musculoskeletal illness and health, current data lack the link to understand the interactions between the host and microbiome. We report that <em>S. thermophilus, L. pentosus</em> (as probiotics), and γ-aminobutyric acid (GABA) harbour against osteoarthritis in vivo and alleviate IL-1β induced changes in chondrocytes in vitro. We examined the increased GABA concentration in mice's serum and small intestine content followed by bacterial treatment. The treatment inhibited the catabolism of cartilage and rescued mice joints from degradation. Furthermore, the anabolic markers upregulated and decreased inflammatory markers in mice knee joints and chondrocytes. This study is the first to represent GABA's chondrogenic and chondroprotective effects on joints and human chondrocytes. This data provides a foundation for future studies to elucidate the role of GABA in regulating chondrocyte cell proliferation. These findings opened future horizons to understanding the gut-joint axis and OA treatment. Thus, probiotic/GABA therapy shields OA joints in mice and could at least serve as adjuvant therapy to treat osteoarthritis.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 26-39"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000743/pdfft?md5=17795c8fb1abc93eb8a29e28722a4a35&pid=1-s2.0-S2225411023000743-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43122981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zhoushi Qi Ling decoction inhibits the progression of castration-resistant prostate cancer in vivo by regulating macrophage infiltration via IL6-STAT3 signaling","authors":"Hongwen Cao ,&nbsp;Dan Wang ,&nbsp;Renjie Gao ,&nbsp;Lei Chen,&nbsp;Yigeng Feng,&nbsp;Peng Sun","doi":"10.1016/j.jtcme.2023.05.005","DOIUrl":"10.1016/j.jtcme.2023.05.005","url":null,"abstract":"<div><h3>Background and aim</h3><p>Prostate cancer is a leading malignant tumor in men, associated with a high rate of mortality. Androgen deprivation therapy is commonly used to treat prostate cancer, which contributes to the progression of castration-resistant prostate cancer (CRPC). The current therapy has a low survival rate in patients with CRPC. Our study aims to develop a novel effective approach for CRPC treatment and improve survival benefits.</p></div><div><h3>Experimental procedure</h3><p>CRPC cell line PC-3-Luc expressing luciferase and the CRPC cell line PC-3-IL6-Luc stably overexpressing IL-6 were used to establish the xenograft tumor mouse model. The tumor was monitored weekly using Bioluminescence imaging. Infiltrated macrophages were quantified by fluorescence-activated cell sorting using flow cytometry. IL6 mRNA level was determined using quantitative real-time PCR. The protein levels of total STAT3 and phosphorylated STAT3 were determined using Western blot.</p></div><div><h3>Results and conclusion</h3><p>Zhoushi Qi Ling decoction (ZQD) treatment significantly reduced PC3 the xenograft tumor progression and the number of infiltrated macrophages when compared with saline treatment. IL6 mRNA level was remarkedly suppressed by ZQD treatment. Notably, the protein level of phosphorylated STAT3 was significantly decreased in PC3 the xenograft tumor treated with ZQD compared to saline treatment. Our findings demonstrated that ZQD treatment significantly reduced the progression of prostate cancer, evidenced by the reduced population of infiltrated macrophages and the inhibition of the IL6/STAT3 pathway.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 19-25"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000603/pdfft?md5=c5400407e9f8415585b69fef4c69703e&pid=1-s2.0-S2225411023000603-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49138082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture on Baihui (DU20) and Xuehai (SP10) acupoints alleviates psoriatic inflammation by regulating neurotransmitter substance P- Neurokinin-1 receptor signaling","authors":"Cong Qi ,&nbsp;Fang Feng ,&nbsp;JianNing Guo ,&nbsp;Yu Liu ,&nbsp;XiaoYao Guo ,&nbsp;YuJiao Meng ,&nbsp;TingTing Di ,&nbsp;XueQing Hu ,&nbsp;Yazhuo Wang ,&nbsp;Ning Zhao ,&nbsp;XiaWei Zhang ,&nbsp;Yan Wang ,&nbsp;Jingxia Zhao ,&nbsp;Ping Li","doi":"10.1016/j.jtcme.2023.07.005","DOIUrl":"10.1016/j.jtcme.2023.07.005","url":null,"abstract":"<div><h3>Background</h3><p>At present, acupuncture-related practices have been widely used to treat psoriasis. In our study, we investigated the effect and explored the mechanism of electroacupuncture (EA) on acupoints Baihui (DU20) and Xuehai (SP10) for the treatment of psoriasis.</p></div><div><h3>Methods</h3><p>Imiquimod-induced psoriasis-like mouse model was used in this study. Mice were treated with electroacupuncture at DU20 and SP10 (depth of 2–3 mm, frequency of 2/15 Hz, intensity of 0.5–1.0 mA, 10 min/day). The severity of psoriasis-like lesions for each group was assessed. In addition, histological analysis of the lesions were performed. The levels of inflammatory cytokines were determined using Elisa. The expression levels of Substance P (SP) and NK1R were measured using Western blotting. In addition, NK1R inhibitor was administrated to evaluate the target of electroacupuncture in our mouse model.</p></div><div><h3>Results</h3><p>Electroacupuncture significantly alleviated IMQ-induced skin lesions and epidermal thickness, accompanied with reduced keratinocyte proliferation, CD3⁺, CD4⁺, and CD8⁺ T cells infiltration. The reduced levels of inflammatory cytokines was observed after electroacupuncture treatment. In addition, electroacupuncture inhibited the expression levels of SP and NK1R. NK1R inhibitor could ameliorate lesional symptoms and suppress epidermal thickening and CD3⁺, CD4⁺, and CD8 + T cell infiltration.</p></div><div><h3>Conclusions</h3><p>Electroacupuncture relieved psoriasis-like inflammation and T cell infiltration. This therapeutic action was likely mediated by the modulation of Substance P and its receptor NK1R.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 91-100"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000792/pdfft?md5=1912b64497714134f2b9a21e7986a019&pid=1-s2.0-S2225411023000792-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41519230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gracilaria chorda subcritical-water extracts as ameliorant of insulin resistance induced by high-glucose in zebrafish and dexamethasone in L6 myotubes","authors":"Laxmi Sen Thakuri ,&nbsp;Chul Min Park ,&nbsp;Jin Woo Park ,&nbsp;Dong Young Rhyu","doi":"10.1016/j.jtcme.2023.07.006","DOIUrl":"10.1016/j.jtcme.2023.07.006","url":null,"abstract":"<div><h3>Background and aim</h3><p>Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to insulin. Loss of insulin sensitivity disrupts glucose homeostasis and elevates the risk of developing the metabolic syndrome that includes Type 2 diabetes. This study assesses the effect on subcritical-water extract of <em>Gracilaria chorda</em> (GC) at 210 °C (GCSW210) in IR induction models of high glucose (HG)-induced zebrafish larvae and dexamethasone (DEX)-induced L6 myotubes.</p></div><div><h3>Experimental procedure</h3><p>The dose of HG and DEX for IR induction in zebrafish larvae and L6 myotubes was 130 mM or 0.5 μM. The capacity of glucose uptake was quantified by fluorescence staining or intensity. In addition, the activation of protein and mRNA expressions for insulin signaling (insulin-dependent or independent pathways) was measured.</p></div><div><h3>Results and conclusion</h3><p>Exposure of zebrafish larvae to HG significantly reduced the intracellular glucose uptake with dose-dependnet manner compared to control. However, the group treated with GCSW210 significantly averted HG levels like the insulin-treated group, and significantly up- or down-regulated the mRNA expressions related to insulin production (<em>insα</em>) and insulin signaling pathways. Moreover, the treatment with GCSW210 effectively regulated the protein expression of PI3K/AKT, AMPK, and GLUT4 involved in the action of insulin in IR models of L6 myotubes compared to DEX-treated control. Our data indicate that GCSW210 stimulates activation of PI3K/AKT and AMPK pathways to attenuate the development of IR induced by HG in zebrafish and DEX in L6 myotubes. In conclusion, GCSW210 is a potential agent for alleviating various diseases associated with the insulin resistance.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 82-90"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000810/pdfft?md5=cffa21840dfcf96023d4538c6a69cb26&pid=1-s2.0-S2225411023000810-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136184756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The characterization of traditional Chinese medicine natures and flavors using network pharmacology integrated strategy","authors":"Hong Wang,&nbsp;Wenfeng Wei,&nbsp;Jing Liu,&nbsp;Shuang Zhang,&nbsp;Yunli Zhao,&nbsp;Zhiguo Yu","doi":"10.1016/j.jtcme.2023.12.004","DOIUrl":"10.1016/j.jtcme.2023.12.004","url":null,"abstract":"<div><h3>Background and aim</h3><p>Due to the complexity of TCM ingredients and medication compatibility, TCM cannot be used like chemical medicines. The theory of “Four Natures and five Flavors” provides a theoretical basis for the use of TCM. “Four Natures and five Flavors” are originated from pharmacological rules based on clinical practices. Whereas, How to describe and characterize “Natures”(Warm, Hot, Cold and Cool) and “Flavors” (Pungent, Sour, Sweet, Bitter and Salty) scientifically remain the issue that needs to be solved. The aim of this study is to establish the TCM characterization models based on the integrated pharmacology network strategy and provide a deeper understanding of TCM theory.</p></div><div><h3>Experimental procedure</h3><p>Five “Pungent-Neutral”, nine “Sweet-Neutral and nine “Bitter-Neutral” TCMs were selected to characterize the “Flavors” (Pungent, Sweet and Bitter). Nine “Pungent-Warm” and nine “Bitter-Cold” TCMs were selected to characterize the “Natures” (Warm and Cold). The screened chemical ingredients were analyzed by classification and the screened characteristics targets were analyzed by GO and KEGG enrichment analysis.</p></div><div><h3>Results and conclusion</h3><p>In the “Pungent” group, flavonoids are the most. “Pungent” may have immune-regulatory effects and potential anticancer activity. In the “Sweet” group, isoflavones are the most. “Sweet” are related to effectively invigorate health. Fatty acids in the “Warm” group are the most. Flavonoids in the “Cold’ group are far more than other components. “Warm” and “Cold” are both related to fatty acid and energy metabolism.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 3","pages":"Pages 343-349"},"PeriodicalIF":4.5,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023001384/pdfft?md5=9062875cd7de154665e6dc5e2908a99b&pid=1-s2.0-S2225411023001384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcuma longa alone and in combination with pioglitazone attenuates paraquat-induced lung injury in rats through improving inflammation, oxidative stress and fibrosis","authors":"Seyedeh Zahra Ghasemi, Sima Beigoli, S. Behrouz, Z. Gholamnezhad, Nema Mohammadian Roshan, M. Boskabady","doi":"10.1016/j.jtcme.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.jtcme.2023.12.001","url":null,"abstract":"","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"12 10","pages":""},"PeriodicalIF":4.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139023644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A diet enriched with Pistacia atlantica fruits improves the female rats' reproductive system","authors":"Manijeh Dogani ,&nbsp;Nayere Askari ,&nbsp;Ali Kalantari Hesari","doi":"10.1016/j.jtcme.2023.09.004","DOIUrl":"10.1016/j.jtcme.2023.09.004","url":null,"abstract":"<div><h3>Background and aim</h3><p>Baneh (<em>Pistacia atlantica</em>) is a plant species that is commonly consumed as food and has a long-standing traditional use as a sexual enhancer. Despite its widespread use, a limited amount of academic and scientific literature is available regarding its potential impact on the reproductive system. The present research aimed to study the effect of a diet enriched with Baneh on the female rats’ reproductive system.</p></div><div><h3>Experimental procedure</h3><p>Three groups of rats (n = 8) were subjected to the intended diet for six weeks. Subsequently, their histomorphometric parameters, sex hormone levels, as well as the expression of oxytocin (OXT) and oxytocin receptor (OXTR) genes were measured. The rats’ serum vitamin D, zinc, and lipid profiles were also evaluated.</p></div><div><h3>Results and conclusion</h3><p>Results revealed that compared to the normal food, the diet containing 20 % Baneh significantly increased the progesterone and estradiol levels three and two times, respectively. It decreased the total body weight while increasing the ratio of ovary weight to the body weight. Furthermore, the Baneh-enriched diet raised HDL, zinc, and vitamin D levels, though it reduced the LDL and TG levels by 15 μg/dl and 24 μg/dl, respectively, and the concentration of ovary malondialdehyde decreased by 50 % in the treated group. Also, the diet increased the follicle graph, corpus luteum, the thickness of the epithelium, the number of endometrial glands, and the expression of both <em>OXT</em> and <em>OXTR</em> genes. Our findings suggested that <em>P. atlantica</em> could considerably improve the female sex hormone levels and their reproductive system.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 3","pages":"Pages 335-342"},"PeriodicalIF":4.5,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023001013/pdfft?md5=c89325b06fbc02c4920852738ea6fa25&pid=1-s2.0-S2225411023001013-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}