KCNJ11 基因的分子研究及其与 Prakriti 在预防和控制 2 型糖尿病方面的相关性

IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
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引用次数: 0

摘要

阿育吠陀认为,每个人都拥有一个被称为 "普拉克里提"(Prakriti)的独特实体,它使每个人在身体、生理和心理上都与众不同。这一实体还决定了个体对特定刺激的反应,而且据信这种反应并非完全由遗传决定。本研究旨在从现代分子角度验证阿育吠陀的 "普拉克里提"(Prakriti)概念,以加强个性化和精确的治疗方法。本研究旨在调查 KCNJ11 基因在 2 型糖尿病(T2DM)易感性中的作用。研究涉及对 112 名 T2DM 患者和 112 名健康人的三个主要普拉克里蒂组别(Vata、Pitta 和 Kapha)进行等位基因挖掘。研究分析了负责胰岛素分泌膜孔形成的 KCNJ11 基因,以确定不同般若类型对 T2DM 的易感性。MutPred工具预测了与疾病相关的氨基酸置换的分子原因。研究结果表明,只有 Pitta 和 Kapha 般若体被诊断为糖尿病,而在健康人对照组中,所有三种般若体都存在。研究人员制作了一个蛋白质模型,并观察了每个组别的蛋白质序列因同义和非同义突变而发生的变化。这些变化最终导致了 T2DM 的出现。根据研究结果,Prakriti 组的蛋白质功能可能会因为非同义突变和蛋白质水平上氨基酸的差异而发生变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Molecular study of the KCNJ11 gene and its correlation with Prakriti to preventing and managing type 2 diabetes

Molecular study of the KCNJ11 gene and its correlation with Prakriti to preventing and managing type 2 diabetes

In Ayurveda, every individual is believed to possess a unique entity known as Prakriti, which distinguishes them from others physically, physiologically, and psychologically. This entity also determines an individual's response to a particular stimulus, and it is believed that such responses are not solely determined by genetics. The present research aims to validate the Ayurvedic concept of Prakriti from a modern molecular perspective to strengthen the personalized and precise treatment approach. A study was conducted to investigate the role of the KCNJ11gene in the susceptibility of individuals to type 2 diabetes mellitus (T2DM) with their metabolic status. The research involved allele mining on three major Prakriti groups - Vata, Pitta, and Kapha - in 112 patients with T2DM and 112 healthy individuals. The KCNJ11 gene, responsible for insulin secretion membrane pore formation, was analyzed to determine the susceptibility of different Prakriti types to T2DM. The MutPred tool predicted the molecular cause of disease-related amino acid substitution. According to the study, only Pitta and Kapha Prakriti were diagnosed with diabetes, while all three Prakriti types were present in the control group of healthy individuals. A protein model was prepared, and the changes resulting from mutations were observed for each group in their protein sequence, both as synonymous and non-synonymous mutations. Ultimately, these changes contributed to the manifestation of T2DM. Based on the findings, it appears that Prakriti groups may experience changes in protein function due to nonsynonymous mutations and differences in amino acids at the protein level.

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来源期刊
Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine Medicine-Complementary and Alternative Medicine
CiteScore
9.30
自引率
6.70%
发文量
78
审稿时长
66 days
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