儿童阻塞性睡眠呼吸暂停的中医综合治疗

IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Wan-Yu Lai , Chang-Ching Wei , Chien-Heng Lin , Liang- Wen Hang , Ying-Hsiu Shih , Fen-Wei Huang , Hung-Rong Yen
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引用次数: 0

摘要

目的阻塞性睡眠呼吸暂停(OSA)是一种慢性疾病,影响1%-6%的儿童。材料与方法在这项回顾性队列研究中,我们评估了2009年至2020年间多导睡眠图(PSG)参数和临床特征的差异。研究纳入了确诊为 OSA 的 12 岁儿童(508 人),并将其分为 ITCM 队列、西医队列和手术队列。结果ITCM队列、WM队列和手术队列中分别有56名(11%)、324名(63.8%)和128名(25.2%)患者。在 ITCM、WM 和手术组别中,分别有 17、26 和 33 名患者接受了 PSG 随访研究。在 ITCM 随访队列中,AHI 明显降低(从 9.59 降至 5.71,p < 0.05)。在 WM 随访队列(19.46 至 20.50,p < 0.05)和手术随访队列(18.04 至 18.85,p < 0.01)中,BMI 明显增加。比较 ITCM 和 WM 队列,发现治疗后 RDI 的变化有显著差异(ITCM:-6.78,WM:0.51,p < 0.05)。在 ITCM 随访队列中,处方最多的中药配方是连翘和板蓝根合剂。结论 中医治疗可显著降低 RDI 并控制 BMI。我们发现了治疗小儿 OSA 的潜在中医疗法。我们发现了治疗小儿 OSA 的潜在中医疗法,但还需要进一步研究其药理机制和临床疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Integrative traditional Chinese medicine treatment for children with obstructive sleep apnea

Integrative traditional Chinese medicine treatment for children with obstructive sleep apnea

Purpose

Obstructive sleep apnea (OSA) is a chronic disease that affects 1%–6% of children. Our study aims to explore the effectiveness and clinical characteristics of integrative Traditional Chinese Medicine (ITCM) for pediatric OSA.

Materials and methods

In this retrospective cohort study, we assessed differences of polysomnography (PSG) parameters and clinical characteristics between 2009 and 2020. Children <12 years old diagnosed with OSA (n = 508) were included and were categorized into ITCM cohort, western medicine (WM) cohort ,and surgery cohort. Outcomes were apnea-hypopnea index (AHI), respiratory disturbance index (RDI), and body mass index (BMI).

Results

There were 56 (11%), 324 (63.8%), and 128 (25.2%) patients in the ITCM, WM, and surgery cohorts. Among 17, 26, and 33 patients in the ITCM, WM, and surgery cohorts underwent follow-up PSG studies, respectively. In the ITCM follow-up cohort, AHI were significantly reduced (9.59 to 5.71, p < 0.05). BMI significantly increased in the WM follow-up cohort (19.46 to 20.50, p < 0.05) and the surgery follow-up cohort (18.04 to 18.85, p < 0.01). Comparing ITCM to WM cohort, a significant difference was found between the changes in RDI (ITCM: −6.78, WM: 0.51, p < 0.05) after treatment. Among ITCM follow-up cohort, the most prescribed TCM formula was Forsythia and Laminaria Combination. The most prescribed TCM herb was Ephedrae Herba.

Conclusions

ITCM therapy can significantly reduce RDI and control BMI. We identified potential TCM treatments for pediatric OSA. Further study of the pharmacological mechanisms and clinical efficacy is warranted.

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来源期刊
Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine Medicine-Complementary and Alternative Medicine
CiteScore
9.30
自引率
6.70%
发文量
78
审稿时长
66 days
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