Journal of the Indian Chemical Society最新文献

{"title":"A tyrosinase-functionalized graphene Nanofiber/AuNP biosensor for clinical detection of alkaline phosphatase","authors":"Preeti Kumari,&nbsp;Minakshi Sharma","doi":"10.1016/j.jics.2025.102110","DOIUrl":"10.1016/j.jics.2025.102110","url":null,"abstract":"<div><div>A novel graphene nanofiber-based electrochemical biosensing strategy was developed for ultrasensitive and specific ALP detection using the tyrosinase enzyme. Gold nanoparticles decorated GNFs were utilized as a signal amplification platform for electrochemical detection. GNFs/AuNPs/Tyrosinase modified PG surface utilized as a catalytic amplification platform for ALP activity determination. ALP act as biomarker for wide range of clinical conditions specially, liver and bone disorders. The optimum pH, temperature, and phenyl phosphate substrate concentration for the fabricated sensor were 8, 30 °C, and 0.1 mM, respectively. The proposed biosensor exhibits excellent selectivity and sensitivity with a dynamic linear range from 1 to 2200U/L with a detection limit of 1U/L, along with better reproducibility. Human serum samples of healthy individuals and liver patients were successfully analyzed for ALP detection with good results via a simple and rapid approach.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102110"},"PeriodicalIF":3.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PEG-functionalized ZnO nanoparticles synthesized by Co-precipitation for improved antibacterial performance","authors":"Linga Murthy Ande,&nbsp;Mainampati Srinivasa Reddy","doi":"10.1016/j.jics.2025.102107","DOIUrl":"10.1016/j.jics.2025.102107","url":null,"abstract":"<div><div>Zinc oxide nanoparticles (ZONPs) have attracted substantial attention in biomedical applications because of their potent antibacterial properties, primarily attributed to their ability to generate reactive oxygen species and interact with microbial membranes. In the present research work, ZONPs were synthesized using the co-precipitation method and subsequently modified with urea and varied polyethylene glycol to enhance their physicochemical and antibacterial properties. The influence of varying PEG concentrations (0.1, 0.3, and 0.5 g) on the structural, morphological, and optical properties, and their antibacterial efficacy of ZnO was systematically investigated. Structural, morphological, and optical characterizations were performed through X-ray diffraction, Raman spectroscopy, Field emission scanning electron microscopy (FESEM) with EDX, and UV–Visible spectroscopy. The antibacterial efficacy was measured by using Agar well method. The synthesized ZONPs exhibited well-defined crystallinity with surface modifications influenced by PEG content. Among the different PEG loadings, the sample prepared with 0.3 g PEG showed improved surface morphology and higher ROS generation compared to those obtained with 0, 0.1, and 0.5 g PEG. Antibacterial assessment at 1 mg/mL revealed inhibition zones of 16 mm against Staphylococcus, 14 mm against Bacillus, 13 mm against Klebsiella, and 12 mm against E. coli, indicating effective broad-spectrum activity.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102107"},"PeriodicalIF":3.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and optical properties of ZnO and Cu-doped ZnO thin films and the influence of surface defects on glucose oxidation","authors":"Fariba Amani,&nbsp;Hassan Bidadi,&nbsp;Mohammad Ali Mohammadi,&nbsp;Mohammad Ghafouri","doi":"10.1016/j.jics.2025.102108","DOIUrl":"10.1016/j.jics.2025.102108","url":null,"abstract":"<div><div>Zinc oxide (ZnO) and 4 % copper-doped ZnO (Cu–ZnO) thin films were synthesized by the co-precipitation method, deposited via spin-coating, and annealed at 450 °C for 6 h. Structural and surface analyses using X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and energy-dispersive X-ray spectroscopy (EDX) confirmed enhanced crystallinity and grain growth, with crystallite size increasing from ∼17 to ∼31 nm and surface roughness from 2.8 to 8.3 nm after Cu doping and annealing. Photoluminescence (PL) spectra revealed suppressed oxygen-vacancy–related emission, consistent with reduced defect levels and improved crystallinity. Glucose oxidation, investigated by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, showed that oxygen vacancies dominate in unannealed ZnO, whereas surface copper oxide (CuO) species drive oxidation in annealed Cu–ZnO through Cu²⁺/Cu³⁺ redox reactions. These results demonstrate that defect engineering combined with low-Cu-content doping in thin films effectively enhances glucose oxidation, offering a simple yet effective strategy for ZnO-based non-enzymatic glucose sensors.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102108"},"PeriodicalIF":3.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated DFT, topological, and ADME analysis of isatin-based Schiff bases: Synthesis and in silico antidiabetic evaluation","authors":"C. Raksha,&nbsp;N. Ansiya,&nbsp;Akhil Sivan","doi":"10.1016/j.jics.2025.102105","DOIUrl":"10.1016/j.jics.2025.102105","url":null,"abstract":"<div><div>This paper presents a comparative reactivity analysis of three isatin-derived Schiff bases for <em>in silico</em> antidiabetic applications. The synthetic accessibility of the isatin derivatives <strong>ISAN</strong>, <strong>ISOPD</strong>, and <strong>ISPPD</strong> was achieved through a wet-lab manner, followed by their characterisation using FT-IR, NMR, and HRMS analyses. The electronic environment, stability, and reactivity were comprehensively evaluated using geometry optimisation, FMO analysis, vibrational assignments, MEP plot, and NBO analysis based on DFT calculations. The reactivity profiling of the title compounds was validated through Fukui function analysis, grounded in conceptual DFT. Covalent and non-covalent interactions, including intramolecular hydrogen bond energies, were elucidated through topological analyses using ELF, LOL, RDG, and QTAIM methods. ADMET studies were conducted to determine the physicochemical properties of the title compounds. Subsequently, the potential of the isatin-appended molecules was evaluated computationally through molecular docking with two α-glucosidase enzymes, along with binding energy calculations. <strong>ISPPD</strong> exhibits higher binding energy than the reference compound acarbose, along with twice the number of active site interactions, highlighting its potential as a promising antidiabetic candidate.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102105"},"PeriodicalIF":3.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly synthesis of water-soluble zinc and iron complexes from Boehmeria virgata and their enzyme inhibition potential","authors":"Kanika Rana ,&nbsp;Yasha Dogra ,&nbsp;Neha Bhandari ,&nbsp;Sushila Devi ,&nbsp;Meena Kumari","doi":"10.1016/j.jics.2025.102101","DOIUrl":"10.1016/j.jics.2025.102101","url":null,"abstract":"<div><div>The synergy between the extract's natural compounds and metal ions opens new avenues for designing novel bioactive materials with enhanced therapeutic benefits. Within this research, the creation and evaluation of zinc and iron complexes derived from the leaf extract of <em>Boehmeria virgata</em> were examined. This study investigates the extraction process of <em>Boehmeria</em> and its subsequent coordination with metal ions (Zn²⁺ and Fe²⁺), resulting in the formation of water-soluble Zn (II) complex and Fe (II) complex. The formation of metal complexes was confirmed through various physicochemical and spectral analyses, including FTIR, UV–visible, mass spectrometry, and ¹H NMR. The redox behavior of the complexes in solution was probed with the aid of electrochemical techniques. These studies provide insights into the complexes' electron transfer processes and stability under different conditions. Thermogravimetric analysis (TGA) provided information on decomposition patterns and thermal degradation, offering insights into their durability at elevated temperatures. Furthermore, these complexes were explored for their antimicrobial, cytotoxicity, enzyme inhibition, and antioxidant activities. Results of antimicrobial and antioxidant activities suggest that the metal-functionalized <em>Boehmeria</em> extract exhibits potential biological activity. The metal complexes demonstrated no cytotoxicity under the tested conditions, maintaining cell viability above 97 %. Meanwhile, the Zn(II) complex exhibited the most potent enzyme inhibitory activity, achieving 99.09 % inhibition, indicating near-complete suppression of enzymatic function.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102101"},"PeriodicalIF":3.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sensitive analytical method for the determination of copper at trace levels with Sb2O4 nanoparticles based dispersive solid phase extraction","authors":"Hakan Serbest ,&nbsp;Sezgin Bakirdere","doi":"10.1016/j.jics.2025.102103","DOIUrl":"10.1016/j.jics.2025.102103","url":null,"abstract":"<div><div>This study presents antimony oxide nanoparticles (AO-NPs)-based dispersive solid phase extraction (DSPE) method for the determination of copper ions in lavender tea matrices with high sensitivity and accuracy at trace levels by flame atomic absorption spectrometry (FAAS) system. AO-NPs used as sorbent material were produced by microwave-assisted synthesis method by setting a defined temperature program. Limit of detection (LOD) value was calculated as 0.41 μg L⁻¹ under optimal operating conditions. Linearity was obtained in the range of 2.5–40 μg L⁻¹. Increase in detection power/sensitivity were calculated based on LOD values of FAAS and AO-NP-DSPE-FAAS systems and the slopes of the calibration plot equations and were found to be 169.4 and 123.1, respectively. The recovery results in lavender tea matrices recorded in the range of 103 %–118.2 % by employing the matrix matching calibration strategy indicated that the presented method is feasible for lavender tea and similar matrices.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102103"},"PeriodicalIF":3.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly fabrication of rGO-Pr6O11 nanocomposites: Enhanced photocatalysis and smoke gas sensing performance","authors":"S. Priyanka Chakradhar ,&nbsp;B.R. Radha Krushna ,&nbsp;S.C. Sharma ,&nbsp;S. Sasidharan ,&nbsp;R. Anitha ,&nbsp;K. Manjunatha ,&nbsp;Sheng Yun Wu ,&nbsp;H. Nagabhushana","doi":"10.1016/j.jics.2025.102084","DOIUrl":"10.1016/j.jics.2025.102084","url":null,"abstract":"<div><div>This study introduces a novel approach to the sonochemical synthesis and characterization of a multifunctional nanocomposites (NCs) composed of reduced graphene oxide (rGO) functionalized with praseodymium oxide (Pr₆O₁₁) nanoparticles (NPs). A green synthesis route was employed, utilizing <em>Citrus sinensis</em> and <em>Syzygium samarangense</em> fruit extracts as capping and reducing agents for the fabrication of Pr₆O₁₁ NPs and the reduction of graphene oxide (GO) respectively. Comprehensive characterizations, including TG-DTA, XRD, FT-IR, FE-SEM, EDX, TEM and XPS, were conducted to analyze the structural, morphological, and optical properties of rGO, Pr₆O₁₁, and the resulting rGO@Pr₆O₁₁ NCs. Morphological assessments confirmed the successful decoration of rGO surfaces with Pr₆O₁₁ NPs. The average crystallite size of the NCs, as determined from X-ray diffraction patterns, ranged between 22 and 23 nm. UV–Vis absorbance studies estimated the band gap of the NCs to be 2.65 eV. Photocatalytic performance was evaluated through the degradation of Congo red dye under sunlight. The results demonstrated a significant enhancement in photocatalytic efficiency, with Pr₆O₁₁ NPs achieving 70.98 % degradation and the rGO@Pr₆O₁₁ NCs facilitating complete degradation (100 %) within 100 min. The environmental impact of the synthesized NCs was further assessed by using treated dye wastewater for plant growth, resulting in healthy development of <em>Macrotyloma uniflorum</em> (horse gram) plants within one week, outperforming untreated dye solutions and normal water. Additionally, the rGO@Pr₆O₁₁ NCs exhibited excellent gas oxidation properties when exposed to smoke, significantly reducing CO levels by 98.93 % and achieving complete removal of NO_x and SO₂ gases, demonstrating its potential as a smoke sensor. The green synthesis approach highlights the biocompatibility and cost-effectiveness of the NCs, underscoring its potential in environmental remediation through applications in photocatalysis and air purification.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102084"},"PeriodicalIF":3.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of jet electrodeposited Ni-W-Al2O3 coatings","authors":"Lixin Wei ,&nbsp;Yunwei Zhu ,&nbsp;Kedi Jiang ,&nbsp;Chunqing Zhao","doi":"10.1016/j.jics.2025.102079","DOIUrl":"10.1016/j.jics.2025.102079","url":null,"abstract":"<div><div>This study investigates the influence of fluid flow rates (<em>V</em>_<em>i</em>) on the performance of Ni-W-Al₂O₃ coatings. The coatings were deposited <em>via</em> jet electrodeposition with varying <em>V</em>_<em>i</em> to assess their impact on coating properties. Scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), microhardness testing, and wear resistance evaluations were employed to characterize the microstructure, composition, hardness, and wear resistance of the coatings. The results showed that the coating deposited at 1.0 m/s exhibited a uniform, compact, and fine microstructure. The thicknesses of the three coatings were 28.1 μm, 46.5 μm, and 37.4 μm, respectively. The sample deposited at 1.0 m/s displayed the lowest intensity of the Ni-W diffraction peak. XPS analysis revealed a complex chemical composition, including both metallic and oxidized forms of nickel, tungsten, and aluminum, along with various oxygen species. At 1.0 m/s, the Ni-W-Al₂O₃ coating achieved a microhardness of 725.4 HV, the highest among the four coatings and approximately 61.4 % greater than that of the Ni-W coating. The friction coefficient and wear loss for this sample were 0.46 and 15.7 mg, respectively. It exhibited the smallest wear scar, approximately 13.5 μm and about one-fifth that of Q235 steel demonstrating excellent wear resistance. Electrochemical testing further confirmed that the coating deposited at 1.0 m/s exhibited the highest corrosion resistance, characterized by the most positive corrosion potential (−0.104 V), the lowest corrosion current density (7.582 × 10⁻⁷ A cm⁻²), and the highest polarization resistance (8167.0 Ω cm²), indicating improved protective performance in corrosive environments.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102079"},"PeriodicalIF":3.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence and modification mechanism of magnesium oxide with varying activities on the performance of sodium sulfate activated slag","authors":"Xinkuang Ning ,&nbsp;Keyue Fang ,&nbsp;Chengyou Wu","doi":"10.1016/j.jics.2025.102095","DOIUrl":"10.1016/j.jics.2025.102095","url":null,"abstract":"<div><div>Sodium sulfate activated slag (SSAS) is a low-carbon cementitious material. The low alkalinity of Na₂SO₄ results in an extremely low hydration rate, leading to reduced early strength. It is found that adding magnesium oxide (MgO) can effectively improve the mechanical properties of SSAS. The main preparation method of magnesium oxide is calcining magnesite. However, the calcination temperature in the preparation of MgO greatly affects its activity. Based on this, this article uses different active MgO as modifiers in the preparation of SSAS. The results indicate that the addition of MgO accelerates the hydration reaction of SSAS, effectively enhancing its early compressive strength. The MgO with high activity accelerates the hydration of SSAS, it leads to the formation of hydrotalcite phase, significantly affecting the later-stage strength. The lower active MgO mainly forms Mg-doped Calcium Alumino Silicate Hydrate (CASH) gel in SSAS, which improves the hydration degree of slag and the long-term strength of SSAS compared with higher active MgO modified SSAS. Incorporating 3 % of active MgO calcined at 700 °C into SSAS, the compressive strengths at 28 and 90 days reached 52.5 and 75 MPa.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102095"},"PeriodicalIF":3.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical dopamine sensing using Mn-doped CeO2 nanomaterial-modified carbon paste electrode for biomedical applications","authors":"Nandini Robin Nadar ,&nbsp;J. Deepak ,&nbsp;Samir Sahu ,&nbsp;S.C. Sharma ,&nbsp;B.R. Radha Krushna ,&nbsp;I.S. Pruthviraj ,&nbsp;Jayannan J. ,&nbsp;Anitha R. ,&nbsp;Sindhya K.S. ,&nbsp;Jittu V. Thomas ,&nbsp;H. Nagabhushana ,&nbsp;Ravi Kumar R.","doi":"10.1016/j.jics.2025.102096","DOIUrl":"10.1016/j.jics.2025.102096","url":null,"abstract":"<div><div>Many neurological conditions (NC), such as Aromatic <span>l</span>-amino decarboxylase deficiency (AADC), Parkinson's disease (PD) are linked to aberrant levels of dopamine (DA), which signifies the need to monitor DA content for the diagnosis and effective medication. In the present study, electrochemical detection of dopamine was achieved by synthesizing and using a novel manganese-doped cerium oxide (MCO) nanomaterial using carbon paste electrode. In comparison to the bare electrode (BE) with area and current of 0.061 cm² and 32 μA, the modified electrode (MCO-ME) demonstrated a superior electroactive surface area (0.063 cm²) and a noticeably larger peak anodic current (44 μA). For detecting DA, the sensor reached LOD of 0.345 μM at pH 7 and showed significant selectivity with R² = 0.999 in the presence of uric acid (UA). Furthermore, the MCO-ME demonstrated highly consistent stability and endurance by maintaining 91.11 % of its initial activity over 20 consecutive cycles. The MCO ME sensor exhibited excellent repeatability for dopamine (DA) detection with intra and inter electrode RSD values of 1.56 % and 1.4 %, respectively. Recovery studies showed high accuracy with average recovery rate of 94.36 %. According to these findings, MCO has the potential to be a highly effective sensing material for precise dopamine detection.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102096"},"PeriodicalIF":3.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}