Maha Gul Zafar , Mazhar Abbas , Waqas Haider , Tehreem Fatima , Sumaira Sharif , Muhammad Riaz , Osama A. Mohammed , Shahzad Z. Iqbal , Munawar Iqbal , Arif Nazir , Samiah H. Al-Mijalli
{"title":"Molecular docking, dynamics and pharmacokinetics of Curcuma longa phytochemicals: A promising avenue for Parkinson's therapy","authors":"Maha Gul Zafar , Mazhar Abbas , Waqas Haider , Tehreem Fatima , Sumaira Sharif , Muhammad Riaz , Osama A. Mohammed , Shahzad Z. Iqbal , Munawar Iqbal , Arif Nazir , Samiah H. Al-Mijalli","doi":"10.1016/j.jics.2025.101790","DOIUrl":"10.1016/j.jics.2025.101790","url":null,"abstract":"<div><div>This study analyzed <em>Curcuma longa</em> extracts using in vitro antioxidant (NOx radical scavenging assay, FRAP, and DPPH assay) and Parkinson disease-targeted enzyme inhibition assay (AChE and BChE inhibition). The bioactive compounds were identified by LC-MS analysis. The pharmacokinetics, drug likeliness, biological activity profiling and toxicity of these phytochemicals were assessed through in silico ADMET analysis. Molecular docking and molecular dynamics simulation were performed to analyze phytochemicals' binding affinity and stability against the target neurotoxic enzyme monoamine oxidase B (6FW0). The robust antioxidant potential of <em>C. longa</em>-derived phytochemicals is evidenced by significant inhibition of NOx free radicals (25.75 ± 2.99 %), notable ferric reducing potential (0.83 ± 0.032 %), and strong DPPH scavenging activity (75.07 ± 2.26 %). The targeted inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for Parkinson's disease resulted in 42.60 ± 3.54 % and 56.25 ± 2.40 % inhibition, respectively. The <em>C. longa</em> phytochemicals have demonstrated high binding affinities; notably, α-turmerone (−14.1001 kcal/mol), β-turmerone (−14.1001 kcal/mol), and bisdemethoxycurcumin (−13.2892 kcal/mol), underscoring a strong interaction with the targeted protein 6FW0. These phytochemicals show a favorable pharmacokinetic profile, including blood-brain barrier permeability and high lipophilicity. Molecular dynamic simulation and MM-GBSA analysis further confirmed the stable phytochemical-protein interactions, highlighting their neuroprotection. The findings suggest that <em>C. longa</em>-derived phytochemicals show significant potential as neuroprotective agents for Parkinson's disease, with further preclinical and clinical trials required to substantiate their efficacy and develop an effective drug for neurodegenerative disorders.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101790"},"PeriodicalIF":3.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saad Shaaban Professor , Tarek A. Yousef , Emad M. Masoud , Mai M. Khalaf , Hanan A. Althikrallah , Kamal Shalabi , Hany M. Abd El-Lateef
{"title":"Diorganyl diselenide hybrids as effective corrosion inhibitors for carbon steel in HCl solution","authors":"Saad Shaaban Professor , Tarek A. Yousef , Emad M. Masoud , Mai M. Khalaf , Hanan A. Althikrallah , Kamal Shalabi , Hany M. Abd El-Lateef","doi":"10.1016/j.jics.2025.101794","DOIUrl":"10.1016/j.jics.2025.101794","url":null,"abstract":"<div><div>Herein, we present the investigation of the potential of diorganyl diselenide bis-Schiff bases <em>N</em>,<em>N'</em>-(diselanediylbis(4,1-phenylene))bis(1-(4-fluorophenyl)methanimine) <strong>(DSBSF)</strong>, <em>N</em>,<em>N'</em>-(diselanediylbis(4,1-phenylene))bis(1-(4-bromophenyl)methanimine) <em>(</em><strong>DSBSBr</strong><em>)</em>, and <em>N,N'</em>-(diselanediylbis(4,1-phenylene))bis(1-(2-nitrophenyl)methanimine) <strong>(DSBSNO<sub>2</sub>)</strong> for the corrosion inhibition of steel in HCl using potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS), computational density functional theory (DFT) methods, and Monte Carlo (MC) simulations. The electrochemical results showed that <strong>DSBSF</strong>, <strong>DSBSBr</strong>, and <strong>DSBSNO<sub>2</sub></strong> presented supreme protection efficacies of 93.84, 96.12, and 98.21 %, respectively, at 3.2 × 10<sup>−4</sup> M. Moreover, polarization investigations showed that the prepared diselenide-based bis-Schiff bases are mixed-type corrosion inhibitors. Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) observations confirm the adsorption of inhibitor molecules onto the C-steel surface, forming a protective film that effectively minimizes corrosion. This adsorption behavior aligns with the Langmuir adsorption isotherm and incorporates chemical and physical adsorption mechanisms. Additionally, the experimental results were confirmed by DFT-based parameters and MC simulation calculations. Both the experimental findings and computational results showed strong agreement. Overall, theoretical and electrochemical studies showed that the investigated diselenide-based bis-Schiff bases act as respectable inhibitors for steel acidic corrosion—their inhibition capacity upsurges when their doses are increased.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101794"},"PeriodicalIF":3.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zahra Moghadasi , Jayanti Makasana , Anjan Kumar , Rekha M. M , Aman Shankhyan , T. Anand , Kamal Kant Joshi
{"title":"A novel multi-functional nanoporous Cu/SO3H@zeolite-Y for multicomponent synthesis of 1,2,3-Triazoles","authors":"Zahra Moghadasi , Jayanti Makasana , Anjan Kumar , Rekha M. M , Aman Shankhyan , T. Anand , Kamal Kant Joshi","doi":"10.1016/j.jics.2025.101787","DOIUrl":"10.1016/j.jics.2025.101787","url":null,"abstract":"<div><div>In this manuscript, we introduce a novel multi-functional nanoporous catalyst, Cu/SO<sub>3</sub>H@zeolite-Y, and its application in the green and efficient synthesis of β-hydroxy-1,2,3-triazoles through a one-pot multicomponent reaction. This approach involves the conversion of diverse epoxides—alkyl or aryl—to their corresponding triazole derivatives, utilizing sodium azide and alkynes. The synthesis of the Cu/SO<sub>3</sub>H@zeolite-Y catalyst is tailor-made to provide a high surface area with acidic sites and copper centers, offering a unique dual-functionality that catalyzes the cycloaddition and azidation processes in a single reaction vessel. Characterization techniques such as FT-IR, XRD, SEM, TEM, and BET confirmed the successful creation of this nanoporous structure, which boasts excellent stability and dispersal of active sites. Under optimized conditions, the Cu/SO<sub>3</sub>H@zeolite-Y catalyst facilitates the transformation with excellent yields and selectivity, requiring mild reaction. Moreover, the catalyst showcases remarkable reusability with only a minor decrease in activity over multiple cycles of the reaction. The environmentally benign nature of this synthetic route, including using water as the solvent and reduced waste generation, further emphasizes its alignment with sustainable chemical practices. This study provides a new perspective on the utility of nanoporous materials in organic synthesis, with significant implications for pharmaceutical development, where 1,2,3-triazoles are a prominent structural motif due to their medicinal properties.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101787"},"PeriodicalIF":3.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An insight for the sensing ability of graphene oxide for pymetrozine through electrochemical studies, in silico studies, and experimental approaches","authors":"Mohd Aslam , Sandeep Yadav , Madhur Babu Singh , Nobel Tomar , Bhaskara Nand , Kamlesh Kumari , Garima Pandey , Ramesh Chandra , Snigdha Singh , Prashant Singh","doi":"10.1016/j.jics.2025.101779","DOIUrl":"10.1016/j.jics.2025.101779","url":null,"abstract":"<div><div>The study explores the potential of graphene oxide (GO) as a sensing platform for the pesticide pymetrozine (PY), a widely used insecticide with significant environmental and health concerns. GO was synthesized using a modified Hummers' method and functionalized with PY to form GO-PY composites at varying PY concentrations. Comprehensive material characterization, including XRD, FTIR, UV–Vis, SEM, and TGA, confirmed the successful functionalization of GO, highlighting its structural and thermal stability. Computational studies, such as Density Functional Theory (DFT) and Molecular Dynamics (MD) simulations, revealed strong π-π stacking and hydrogen bonding interactions between GO and PY, enhancing the material's electronic and adsorption properties. Electrochemical analyses demonstrated that the GO-modified glassy carbon electrode (GCE) achieved a limit of detection (LOD) of 2.28 μM and maintained sensitivity across concentrations. These findings underline GO's capability as a sensitive, cost-effective, and reliable material for PY detection, offering significant applications in environmental monitoring.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101779"},"PeriodicalIF":3.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed Ali M. Rihan , Richard O. Onchiri , Naftary Gathimba , Bernadette Sabuni , Bheem Pratap
{"title":"Predicting compressive strength of fly ash and sugarcane bagasse ash-based geopolymer concrete using statistical techniques","authors":"Mohammed Ali M. Rihan , Richard O. Onchiri , Naftary Gathimba , Bernadette Sabuni , Bheem Pratap","doi":"10.1016/j.jics.2025.101791","DOIUrl":"10.1016/j.jics.2025.101791","url":null,"abstract":"<div><div>Cement production and other industrial activities are major contributors to environmental and health concerns, primarily due to the substantial amounts of carbon dioxide (CO<sub>2</sub>) emitted into the atmosphere. The use of supplementary cementitious materials can reduce the quantity of cement required, thus lowering CO<sub>2</sub> emissions. One such material, sugarcane bagasse ash, improves the mechanical properties of concrete by promoting a denser mix, which is crucial for achieving higher strength. This study proposes three predictive models’ linear regression (LR), nonlinear regression (NLR), and artificial neural networks (ANN) to estimate the compressive strength of high-strength fly ash geopolymer concrete modified with sugarcane bagasse ash. These models present a practical and cost-effective method for predicting compressive strength, offering a more efficient alternative to traditional approaches that require extended testing. The study utilizes 54 experimental data points from geopolymer concrete mixtures containing sugarcane bagasse ash, collected through experimental work, to develop and assess the prediction models. The models are evaluated using various metrics, including the coefficient of determination (R<sup>2</sup>), root means squared error (RMSE), scatter plot analysis, and mean absolute error (MAE). Among the models tested, the ANN model proves to be the most effective, achieving R<sup>2</sup>, RMSE, and MAE values of 0.905, 2.5004 MPa, and 1.9604, respectively.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101791"},"PeriodicalIF":3.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aya Khadidja Touil , Boumediene Haddad , Silvia Antonia Brandán , Maximiliano A. Iramain , Didier Villemin , Annalisa Paolone , Bekhaled Fetouhi , Nathalie Bar , Mustapha Rahmouni , Serge Bresson
{"title":"Synthesis and characterization of trifluoromethylsulfonate choline ionic liquid using NMR, FT-IR, and FT-Raman spectra with DFT calculations","authors":"Aya Khadidja Touil , Boumediene Haddad , Silvia Antonia Brandán , Maximiliano A. Iramain , Didier Villemin , Annalisa Paolone , Bekhaled Fetouhi , Nathalie Bar , Mustapha Rahmouni , Serge Bresson","doi":"10.1016/j.jics.2025.101786","DOIUrl":"10.1016/j.jics.2025.101786","url":null,"abstract":"<div><div>In this work, the choline trifluoromethylsulfonate ionic liquid [CHO<sup>+</sup>][CF<sub>3</sub>SO<sub>3</sub><sup>−</sup>] was synthesized via anion exchange between choline chloride and lithium trifluoromethylsulfonate in aqueous medium at room temperature. The metathesis synthesis of the targed ionic liquid was confirmed by NMR spectroscopy measurements. TGA measurements revealed that the ionic liquid was stable up to 150 °C, while DSC curves indicated a melting point of +34 °C and a glass transition temperature of approximately −79 °C. The infrared and Raman spectra of the synthesized ionic liquid were compared with DFT calculations at the B3LYP/6–311++G∗∗ level of theory/basis set to achieve complete vibrational band assignment. Differences in band assignment under vacuum or DMSO environment were highlighted. Two possible conformations of the ionic pairwere considered, andby comparing with the experimental results, we were able to show that the most energetically stable conformation involves two intramolecular interactions.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101786"},"PeriodicalIF":3.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cobalt-doped zinc ferrite Nanoparticles: Triggering apoptosis and selective targeting of A549 cells","authors":"B. Jyothish , John Jacob","doi":"10.1016/j.jics.2025.101785","DOIUrl":"10.1016/j.jics.2025.101785","url":null,"abstract":"<div><div>This study explores the potential of cobalt-doped zinc ferrite nanoparticles (Zn<sub>1-x</sub>Co<sub>x</sub>Fe<sub>2</sub>O<sub>4</sub>) in cancer therapy by investigating the impact of varying cobalt concentrations [x = 0.00 (ZFO), 0.01(COL1), 0.03(COM3), 0.05(COL5), and 0.07(COM7)] on their structural, chemical, and biological properties. A single-phase spinel ferrite structure was confirmed across all compositions using X-ray Diffraction (XRD), which revealed that cobalt doping subtly alters microstructural features like lattice parameters and crystallite size. Fourier Transform Infrared (FTIR) spectroscopy identified key surface functional groups (O–H, COO<sup>−</sup>) that mediate interactions within biological systems. Importantly, <em>in vitro</em> assays on A549 lung cancer cells demonstrated that cobalt-doped zinc ferrite nanoparticles induce dose-dependent cytotoxicity, with specific compositions (COM3 and COM7) exhibiting enhanced anticancer activity, with LC50 values of 46.88 and 49.51 μg/mL, respectively. Cell death was primarily attributed to apoptosis, as shown by flow cytometry. The nanoparticles displayed selective cytotoxicity, exhibiting a therapeutic index (TI) of >4. These findings highlight the promise of cobalt-doped zinc ferrite nanoparticles as a potential platform for targeted cancer therapies, motivating further research into optimizing their design for enhanced therapeutic efficacy and specificity.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101785"},"PeriodicalIF":3.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zahir Ali Siddiqui , Yesuf Seyd , Ravindra Kale , Sandeep More , Nagaiyan Sekar
{"title":"Crystal growth, tautomeric forms, dyeing, UV protection activity, and in-silico nonlinear optics of multifaceted 2-nitroso-1-naphthol","authors":"Zahir Ali Siddiqui , Yesuf Seyd , Ravindra Kale , Sandeep More , Nagaiyan Sekar","doi":"10.1016/j.jics.2025.101783","DOIUrl":"10.1016/j.jics.2025.101783","url":null,"abstract":"<div><div>The work highlights the key findings and properties of two tautomeric forms of the 2-nitroso-1-naphthol (NAN). The single crystal structure of NAN has been identified as an enol-nitroso form with an orthorhombic point group and P 21 21 21 space group. The presence of the keto-oxime tautomer was confirmed in the solution phase using <sup>13</sup>C NMR in DMSO-d6 and CDCl<sub>3</sub>, with characteristic carbonyl carbon peaks at 180.9 ppm and 182.7 ppm. The intriguing photochemical behavior observed under prolonged UV irradiation and its electron acceptor potential indicated by low-lying LUMO values from DFT study and cyclic voltammetry are outlined. The compound's effectiveness in polyester dyeing, resulting in a greenish khaki shade with 2-nitroso-1-naphthol, is also mentioned. It also emphasizes NAN's efficient UV protection, as indicated by its UV protection factor (UPF) values (50+ UPF value; excellent) and their linear increase with shade percentage. Finally, NAN's promising nonlinear optical properties, specifically its first-order hyperpolarizability (<em>β</em><sub><em>0</em></sub>; 7.421 × 10<sup>−30</sup> esu), are highlighted as a material for nonlinear optics. It has shown a six-fold increment compared to α-naphthol) and improved compared to 4-chloro-(-naphthol, 4-metoxy- (-naphthol), and other CHO and OCOMe derivatives mentioned.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101783"},"PeriodicalIF":3.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Salah , A. Khodairy , Heba A. El-Nemr , Amira E. El-Tabey , Mahmoud Elrouby
{"title":"Synthesis and characterization of novel ethoxylated benzimidazole-based surfactants as corrosion inhibitors for carbon steel in acidic environments: DFT calculations","authors":"H. Salah , A. Khodairy , Heba A. El-Nemr , Amira E. El-Tabey , Mahmoud Elrouby","doi":"10.1016/j.jics.2025.101780","DOIUrl":"10.1016/j.jics.2025.101780","url":null,"abstract":"<div><div>Novel ethoxylated benzimidazole-based surfactants (E4NS, E8NS, and E12NS) were synthesized and characterized by FTIR, NMR, and mass spectrometry. Surface tension measurements confirmed their amphiphilic nature. Their corrosion inhibition performance for carbon steel in 1 M HCl was systematically evaluated using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). Results showed that E12NS achieved the highest inhibition efficiency (94.96 % at 250 ppm), with efficiency increasing with the number of ethylene oxide units. EIS measurements revealed enhanced charge transfer resistance, while SEM analysis confirmed the formation of a uniform protective layer on the steel surface. Density functional theory (DFT) calculations supported strong adsorption behavior. The study demonstrates that increasing ethoxylation improves corrosion resistance, highlighting these surfactants as promising cost-effective inhibitors for acidic environments.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101780"},"PeriodicalIF":3.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A comprehensive exploration of graphene and graphene oxide based hydrogels - Methods, characteristics, and applications","authors":"Swati Sharma , Manisha Bhende , Priyanshi Mulwani , Suvarna Patil","doi":"10.1016/j.jics.2025.101782","DOIUrl":"10.1016/j.jics.2025.101782","url":null,"abstract":"<div><div>This review provides a comprehensive overview of the integration of graphene and graphene oxide (GO) in hydrogel systems, detailing the methods of fabrication, elucidating the resultant properties, and highlighting their diverse applications. Graphene derivatives, characterized by outstanding electrical conductivity, thermal stability, and mechanical robustness, impart unique advantages to hydrogel matrices. Their capacity to self-assemble with hydrogel networks and accommodate a wide range of molecules positions them as exceptional gelator. The distinct molecular interactions between graphene derivatives and polymer matrices lead to the development of hydrogels with augmented properties. The application spectrum of graphene oxide-based hydrogels encompasses energy storage, biosensor technology, wastewater treatment, supercapacitors, and biomedical domains. In this review, we underscore the significance of these hydrogels as mechanically resilient materials, proficient drug delivery vehicles, and electrically conductive substrates. Additionally, we present an in-depth analysis of fabrication methodologies, providing insights into optimizing the incorporation of graphene and GO in hydrogel systems. This comprehensive review serves as a valuable resource for researchers and practitioners in the field, offering a nuanced understanding of the potential and versatility of graphene-based hydrogels across a myriad of applications.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101782"},"PeriodicalIF":3.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}