Electrochemical dopamine sensing using Mn-doped CeO2 nanomaterial-modified carbon paste electrode for biomedical applications

Many neurological conditions (NC), such as Aromatic l-amino decarboxylase deficiency (AADC), Parkinson's disease (PD) are linked to aberrant levels of dopamine (DA), which signifies the need to monitor DA content for the diagnosis and effective medication. In the present study, electrochemical detection of dopamine was achieved by synthesizing and using a novel manganese-doped cerium oxide (MCO) nanomaterial using carbon paste electrode. In comparison to the bare electrode (BE) with area and current of 0.061 cm² and 32 μA, the modified electrode (MCO-ME) demonstrated a superior electroactive surface area (0.063 cm²) and a noticeably larger peak anodic current (44 μA). For detecting DA, the sensor reached LOD of 0.345 μM at pH 7 and showed significant selectivity with R² = 0.999 in the presence of uric acid (UA). Furthermore, the MCO-ME demonstrated highly consistent stability and endurance by maintaining 91.11 % of its initial activity over 20 consecutive cycles. The MCO ME sensor exhibited excellent repeatability for dopamine (DA) detection with intra and inter electrode RSD values of 1.56 % and 1.4 %, respectively. Recovery studies showed high accuracy with average recovery rate of 94.36 %. According to these findings, MCO has the potential to be a highly effective sensing material for precise dopamine detection.