Journal of the Indian Chemical Society最新文献

{"title":"Heterojunction p-n type α-Fe2O3/CeO2 composite for photocatalytic dye degradation","authors":"Trupti B. Shinde ,&nbsp;Nilesh N. Mharsale ,&nbsp;Pradnya S. Raut ,&nbsp;Ganesh E. Patil ,&nbsp;Kailas H. Kapadnis","doi":"10.1016/j.jics.2025.101775","DOIUrl":"10.1016/j.jics.2025.101775","url":null,"abstract":"<div><div>Composite p-n type heterojunction photocatalysis offers an environmentally friendly and energy-efficient solution for wastewater treatment, leveraging visible light to degrade pollutants effectively. Herein, firstly CeO₂ and Fe₂O₃ were synthesized using chemical reaction methods, followed by the preparation of a p-n type α-Fe₂O₃/CeO₂ composite catalyst via ball milling and calcination at 500 °C. The synthesized composite was characterized using XRD, FTIR, SEM, Raman spectroscopy, PL and UV–visible spectroscopy to investigate their structural and optical properties. The successful integration of CeO₂ and Fe₂O₃ into the composite was confirmed by the combined features in XRD and Raman analyses, as well as characteristic FTIR peaks at 1143 cm⁻¹ and 1084 cm⁻¹, corresponding to Ce–O–Ce and Fe–O–Fe bridging vibrations. SEM analysis revealed roughly spherical nanoparticles with an average size of 357 nm. UV–visible spectroscopy measurements indicated a reduced band gap of 1.15 eV for the composite, enhancing its visible light absorption. The formation of a stable p-n heterojunction between CeO₂ and Fe₂O₃ improved charge separation and photocatalytic efficiency. The photocatalytic activity of the α-Fe₂O₃/CeO₂ composite was evaluated for the degradation of methylene green dye under visible light irradiation, achieving a maximum degradation efficiency of 95.45 % at an optimal pH of 6 and a catalyst mass of 0.15 g. The relatively low PL intensity observed at 636 nm in the α-Fe₂O₃/CeO₂ nanocomposite suggests that the formation of the heterojunction between α-Fe₂O₃ and CeO₂ facilitates efficient charge carrier separation. This study demonstrates that the α-Fe₂O₃/CeO₂ composite is an effective and stable photocatalyst, with potential applications in environmental remediation, particularly in the treatment of dye-contaminated wastewater.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101775"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-situ engineered graphene-based coatings: Redefining hydrophobicity for corrosion resistance","authors":"Pratik S. Dhumal,&nbsp;Ankita Kadam,&nbsp;Mahesh P. Bondarde,&nbsp;Kshama D. Lokhande,&nbsp;Madhuri A. Bhakare,&nbsp;Surajit Some","doi":"10.1016/j.jics.2025.101777","DOIUrl":"10.1016/j.jics.2025.101777","url":null,"abstract":"<div><div>Graphene is widely recognized for its exceptional chemical, electrical, thermal, and mechanical characteristics, making it highly desirable in materials science. This study focuses on the in-situ reduction of graphene oxide (GO) combined with the functionalization of calcium sulphate (CS) under ambient conditions. The process involves reacting calcium carbonate (CC) with sulphuric acid to produce CS, carbon dioxide, and water through an exothermic reaction that drives the entire process forward. The carbon dioxide generated reacts with water to form carbonic acid, which, along with the reaction environment, facilitates the reduction of GO without requiring external heating. The resulting material, a composite of reduced GO and CS (CSRGO), exhibits significant potential as a hydrophobic, anti-corrosive agent. The hydrophobic nature of CSRGO arises from the integration of CS crystals with RGO sheets, as demonstrated by water contact angle measurements: CSRGO achieves a contact angle of approximately 130°, compared to 45° for CS and 80° for RGO. The anti-corrosion performance of CSRGO was evaluated using a salt spray test, where a CSRGO-coated mild steel (MS) panel was exposed to a 5 % NaCl solution for 21 days, showing excellent resistance to corrosion. Electrochemical analysis further supported these findings, with Nyquist plots indicating superior charge transfer resistance and high series resistance for CSRGO. This straightforward one-pot synthesis approach at room temperature effectively produces a CSRGO composite by reducing GO while simultaneously forming CS crystals. The resulting hydrophobic material shows strong potential as a commercially viable anti-corrosive agent.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101777"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymeric nanocomposite: Titania (TiO2)-Zirconia (ZrO2)-Polyaniline (PANI) for sustainable water pollutant removal","authors":"Satish Arvind Ahire ,&nbsp;Ashwini Ashok Bachhav ,&nbsp;Prashant Bhimrao Koli ,&nbsp;Bapu Sonu Jagdale ,&nbsp;Rajendra Keda Pawar ,&nbsp;Thansing Bhavsing Pawar ,&nbsp;Arun Vitthal Patil","doi":"10.1016/j.jics.2025.101762","DOIUrl":"10.1016/j.jics.2025.101762","url":null,"abstract":"<div><div>Binary/Ternary nanocomposites of polymers have emerged as an effective photocatalyst for environmental remediation, primarily due to their ability to suppress electron-hole recombination. The titania-zirconia (TiO₂–ZrO₂), a binary nanocomposite and titania-zirconia-polyaniline (TiO₂–ZrO₂-PANI), a ternary nanocomposite was synthesized by ultra-sonication and chemical oxidative polymerization techniques, respectively. The prepared catalysts were employed to investigates their photocatalytic efficiency against carbol fuchsin (CF) dye. Various characterization methods like UV–Vis Diffuse Reflectance Spectroscopy (UV-DRS), X-Ray Diffraction Spectroscopy (XRD), Photoluminescence Spectroscopy (PL), Energy Dispersive X-ray Spectroscopy (EDAX), Raman Spectra, Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Selected Area Electron diffraction (SAED) techniques was employed to confirm the structural and optical properties of the nanocomposites. Additionally, the high resolution mass spectrometry (HR-MS) technique was utilized to study the possible fragments and degradation pattern of CB dye. The UV spectrum reveals that the TiO₂–ZrO₂ nanocomposites show the absorption of light in UV region whereas the TiO₂–ZrO₂-PANI nanocomposite shows light absorption in UV–Visible region, with band gap energy 3.43 eV for TiO₂–ZrO₂ nanocomposite and 2.54 eV for TiO₂–ZrO₂-PANI nanocomposite. The XRD analysis indicated that the average crystallite sizes of the TiO₂–ZrO₂ and TiO₂–ZrO₂-PANI nanocomposites were 13.63 and 15.73 nm respectively, revealing the orthorhombic crystalline phase. The photocatalytic performance of synthesized catalysts was assessed for a carbol fuchsin (CF) dye. Several parameters like effect of catalyst dosage, dye concentration, pH, irradiation time and kinetics of degradation reaction was investigated. Optimal conditions for CF dye degradation were identified as an 8 g/L catalyst dosage, 20 mg/L dye concentration and a pH of 7. The study shows that the CF dye degradation reaction follows pseudo-first order kinetics. Under same experimental conditions, the TiO₂–ZrO₂ nanocomposite degrades 60.13 % of the CF dye whereas TiO₂–ZrO₂-PANI nanocomposite degrades the same dye about 96.85 % of in first 10 min exposure of light. The complete degradation (almost 100 %) of the CF dye was achieved in 40 min using TiO₂–ZrO₂ nanocomposite while in 30 min using TiO₂–ZrO₂-PANI nanocomposite.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101762"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of chemical profiles of Swertia species","authors":"Km Swati ,&nbsp;Pamita Bhandari","doi":"10.1016/j.jics.2025.101781","DOIUrl":"10.1016/j.jics.2025.101781","url":null,"abstract":"<div><div><em>Swertia chirayita</em> (Roxb.) H. Karst. is an imperative medicinal herb from <em>Swertia</em> genus, now classified as a critically endangered species. Due to its high pharmaceutical potential and unavailability, finding other phytochemical alternatives is essential for pharmaceutical purposes. Hence, the present study aimed to understand the phytochemistry of unexplored <em>Swertia</em> species (<em>S</em>. <em>purpurascens</em>, and <em>S</em>. <em>cordata</em>) and their phytochemical comparison with <em>S. chirayita</em>. GC-MS analysis demonstrated that <em>S</em>. <em>purpurascens</em> contained the highest number of identified compounds including a maximum of those identified in <em>S. chirayita</em>. Similarly, quantitative analysis (UPLC-DAD) revealed that swertianolin and swertiamarin were present in a major amount in <em>S. purpurascens</em> (74.80 ± 0.53; 77.45 ± 0.18 mg/g) followed by <em>S. chirayita</em> (37.16 ± 0.33; 18.60 ± 0.27 mg/g) although bellidifolin (<strong>1)</strong> was present in a comparable amount (26.41 ± 0.27 and 26.16 ± 0.37 mg/g respectively). However, mangiferin was quantified in high concentration in <em>S. chirayita</em> (108.06 ± 0.40 mg/g) followed by <em>S. cordata</em> (47.75 ± 0.16 mg/g). A UHPLC-QTOF-IMS-based analysis led to the tentative characterization of 65 metabolites in all the analyzed samples. Additionally, non-targeted metabolomics identified a total of 181 metabolites including xanthones, iridoids/seco-iridoids, terpenoids, and flavonoids using the METLIN database. Despite this, comparable total phenolic and flavonoid contents were identified in the analyzed species. The current study aimed to identify a potential alternative to <em>S. chirayita</em> based on its phytochemical profile<em>,</em> which can be utilized as a viable ethnobotanical alternative in the pharmaceutical industry.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101781"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical and Experimental Spectroscopic (FT-IR, FT-Raman & UV), Reactive sites, electronic investigation and biological analysis on Quinic acid- MTT assay on dose-dependent cytotoxicity study","authors":"B. Aysha Rifana ,&nbsp;Johanan Christian Prasana ,&nbsp;S. Sakthivel ,&nbsp;K. Venkata Prasad","doi":"10.1016/j.jics.2025.101778","DOIUrl":"10.1016/j.jics.2025.101778","url":null,"abstract":"<div><div>Quinic acid, a polyhydroxy cyclohexane carboxylic acid found in various plants, exhibits diverse biological functions such as antioxidant, anti-inflammatory, viral-fighting, and hepatoprotective effects. Utilizing density functional theory and experimental spectroscopic techniques, the structural, vibrational, and electronic transition properties were studied in detail. Quinic acid was optimized to attain the lowest energy possible for computing various parameters at its ground state. Theoretical and experimental vibrational analysis was done, and the potential energy distribution percentage for each normal mode was depicted. Electronic transition and band gap energy were analyzed through UV, frontier molecular orbital, and transition density matrix studies. Electronic density distribution across different atoms was observed from molecular electrostatic potential, electron localization function, and localized orbital locator maps. Reduced Density Gradient visualizes weak non-covalent interactions by examining electron density variations. The hyperpolarizability value was found through a non-linear optical study. Biological properties were examined through drug-likeness parameters and protein-ligand docking through molecular docking studies. Molecular docking showed that the title compound binds more effectively to the psoriasis-related protein 4zk0, with a higher binding ability compared to the typical drug dimethyl fumarate, proposing the potential benefits of Quinic acid as a psoriasis medication.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101778"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water vs. salt extraction of bio-coagulant from Leucaena leucocephala pods for removing turbidity from aquaculture effluent","authors":"Mohammad Mohammad Alnawajha ,&nbsp;Setyo Budi Kurniawan ,&nbsp;Siti Rozaimah Sheikh Abdullah ,&nbsp;Ahmad Razi Othman ,&nbsp;Hajjar Hartini Wan Jusoh ,&nbsp;Azimah Ismail ,&nbsp;Hassimi Abu Hasan","doi":"10.1016/j.jics.2025.101784","DOIUrl":"10.1016/j.jics.2025.101784","url":null,"abstract":"<div><div>The aquaculture industry is one of the biggest industries in the world and generates a high quantity of contaminated effluent. Coagulation-flocculation is currently the best practice for aquaculture effluent treatment. This study compared water extraction solutions (WE) and salt extraction solutions (NaCl, KCl, and KNO₃) with concentrations (0.5, 1, and 2 M) of plant-based coagulant from <em>Leucaena leucocephala</em> pods for the treatment of aquaculture effluent. The concentration of the pods in all extraction solutions and the dosage concentration before running the jar test were fixed at 20 g/L and 120 mg/L, respectively. The coagulation activity of WE was 3.78 % while KCl (2 M) and KNO₃ (1 M) have the highest coagulation activities 86.52 % and 86 %, respectively and increased the zeta potential from −17.33 mV into −10.11 mV and −13.37 mV respectively and particle size from 4216 d nm into 14260.5 d nm and 14850 d nm respectively after slow mixing time. Moreover, protein in KCl (2 M) and KNO₃ (1 M) solutions was 1192 mg/L and 1023.80 mg/L, respectively, and polysaccharides were 2391.59 mg/L and 2473.30 mg/L, respectively. The effects of salt extracted <em>L. leucocephala</em> pods solutions on zeta potential and particle size indicated the utilization of charge utilization and bridging mechanisms in the treatment process, and they have high potential to be used in the treatment of other kinds of wastewater.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101784"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the influence of antisolvent (chlorobenzene and toluene) on the morphology of bismuth-based perovskite material for solar cell applications","authors":"Saranya Kumaresan ,&nbsp;Naidu Dhanpal Jayram ,&nbsp;C. Pushpa Priya ,&nbsp;B. Janarthanan ,&nbsp;A. Dinesh ,&nbsp;Manikandan Ayyar ,&nbsp;Rajendra P. Patil ,&nbsp;V. Mohanavel ,&nbsp;M. Santhamoorthy ,&nbsp;S. Santhoshkumar","doi":"10.1016/j.jics.2025.101773","DOIUrl":"10.1016/j.jics.2025.101773","url":null,"abstract":"<div><div>Lead free Bismuth Halide perovskite have been getting huge attention as light absorber layer in photovoltaic device. Photovoltaic device made of MA₃Bi₂I₉ without hole transport layer has been attempted by single step coating method. Antisolvents of chlorobenzene (CB) and toluene (TL) have been used to enhance the photoconversion efficiency and also compared. The hexagonal crystal structure with P63/mmc space group of MA₃Bi₂I₉ thin film is confirmed by XRD analysis and crystal structure is remain unchanged while introduction of antisolvent. The surface morphology of antisolvent treated films are well tuned with definite voids. The band gap is reduced for antisolvent treated films includes for chlorobenzene and Toluene 2.25 eV and 2.20 eV respectively and non-treated film has 2.27 eV MA₃Bi₂I₉ thin film is confirmed via FTIR analysis such as N–H bending and N–H wagging at 1450.29 cm⁻¹ and 885.78 cm⁻¹ respectively. The characteristic study of the photovoltaic device revealed the best performance of toluene solvent with dense and premium quality. The device exhibits maximum power conversion efficiency (PCE) ∼ 0.015 %, V_oc ∼ 0.328 V, J_sc ∼ 0.125 μA/cm² and FF ∼ 0.196 %. It is found that the antisolvent toluene is the best candidate for Bismuth Halide perovskite solar cells with futuristic hope to be used with maximum utilization to get better efficiency.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101773"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-engineered copper oxide nanoparticle for high biocompatible improved wound healing: Comprehensive characterization and in vivo & in vitro assessment","authors":"Valikala Viswanath ,&nbsp;Jayaprakash Meena ,&nbsp;N. Kumaraguru ,&nbsp;N. Sami veerappa ,&nbsp;Paik-kyun Shin ,&nbsp;Jiro Tatsugi ,&nbsp;Kannappan Santhakumar","doi":"10.1016/j.jics.2025.101772","DOIUrl":"10.1016/j.jics.2025.101772","url":null,"abstract":"<div><div>Copper oxide nanoparticles (CuO NPs) were synthesized using a green technique with <em>Ceropegia fimbriifera</em> floral extract. UV–visible spectroscopy showed an absorption band at 302 nm with a 2.4 eV band gap, indicating an optimized size. FTIR analysis confirmed no incompatibilities, with characteristic peaks at 588 cm⁻¹ (M − O), 1052 cm⁻¹ (aliphatic amines), 2340 cm⁻¹, 2912 cm⁻¹, and 3396 cm⁻¹ (N–H and O–H), 1532 cm⁻¹ and 1376 cm⁻¹ (C–H vibrations), 1638 cm⁻¹ (N–H bending), 3323 cm⁻¹ (O–H), 1600 cm⁻¹ (C<img>O), and 1719 cm⁻¹ (C–H). Distinct peaks at 540 cm⁻¹, 596 cm⁻¹, and 1038 cm⁻¹ confirmed the formation of CuO NPs. Raman spectroscopy displayed characteristic peaks at 296 cm⁻¹ (Ag), 617 cm⁻¹ (Ag), and 342 cm⁻¹ (Bg), along with three acoustic modes (2Au + Bu) and nine optical phonon modes (4Au + 5Bu + 2Ag + Bg). Photoluminescence showed a 434 nm peak, indicating semiconductor behavior, while zeta potential (−16.2 mV) suggested moderate stability and XRD revealed an average size of 49.23 nm. Wound healing showed 85.54 ± 0.52 % contraction, while BET reported a pore volume of 0.062 cm³/g and surface area of 12.45 m²/g, suggesting catalytic potential. TEM and SEM analyses revealed spherical, cubic, and irregular particles with an average size of 40 nm, and weight and atomic compositions of 14.58 %, 85.42 %, 9.25 %, and 93.16 %, respectively. SAED confirmed a polycrystalline structure, while XPS showed peaks at 970 eV (Cu 2p), 965 and 945 eV (Cu_2p1/2, Cu_2p3/2), and 956 and 934 eV (Cu_2p1/2, Cu_2p3/2). Antibacterial studies showed activity against gram-positive and gram-negative bacteria, while cytotoxicity on A549 and K562 cells indicated reduced viability.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101772"},"PeriodicalIF":3.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview of pyrazolo[3,4-d]pyrimidine heterocycles: recent synthetic approaches and biological activities","authors":"Ahmed S. Abdelkhalek ,&nbsp;Ahmed Abdulrahman ,&nbsp;Mansour E. Abokull ,&nbsp;Samy M. Ibrahim ,&nbsp;Mostafa K. Soltan ,&nbsp;Mokhtar A. Abdul-Malik ,&nbsp;Shaban A.A. Abdel-Raheem","doi":"10.1016/j.jics.2025.101763","DOIUrl":"10.1016/j.jics.2025.101763","url":null,"abstract":"<div><div>This review provides an up to date perspective on recent progress in synthetic strategies for constructing pyrazolo[3,4-<em>d</em>]pyrimidine frameworks, compounds of significant importance in both synthetic and pharmaceutical chemistry. It examines various efficient synthetic routes for creating diverse and functionalized pyrazolo[3,4-<em>d</em>]pyrimidine scaffolds using innovative methods. These construction methods utilize numerous approaches based on different starting materials, including those derived from pyrazole and pyrimidine, as well as miscellaneous methods such as reactions including acyclic intermediates, one-pot synthesis, solid-phase synthesis, and Diels-Alder reactions. Furthermore, the review highlights the pharmacological significance of pyrazolo[3,4-<em>d</em>]pyrimidines, citing a variety of activities including antimicrobial, anticancer, anti-inflammatory, xanthine oxidase inhibitors, antiviral and antihypertensive effects. This review is intended to support future researchers in the development of bioactive structures based on this versatile scaffold.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101763"},"PeriodicalIF":3.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and antitumor activity of 4-aminoquinazoline derivatives containing morpholine moieties","authors":"Xinxin Zhou,&nbsp;Yicheng Mei,&nbsp;Baowei Yang,&nbsp;Jing Wang,&nbsp;Huiling Tang,&nbsp;Xiaolong Zhang,&nbsp;Changchun Liu","doi":"10.1016/j.jics.2025.101770","DOIUrl":"10.1016/j.jics.2025.101770","url":null,"abstract":"<div><div>Eight 4-(morpholinyl arylamino)quinazoline-6-carbamoyl carboxylic acid methyl esters and four 4-(morpholinyl arylamino)quinazoline-6-carbamoyl hydroxamic acid derivatives were designed and synthesized by integrating morpholine moieties into the 4-aminoquinazoline scaffold, with additional modifications at the 6-position of quinazoline ring. The antitumor potential of these twelve derivatives was evaluated against human lung cancer A549 cells and breast cancer MDA-MB-231 cells using the Cell Counting Kit-8 (CCK-8) proliferation assays. The bioassay results indicated that most of the derivatives exhibited moderate to potent <em>in vitro</em> antiproliferative activity against both cancer cells. Particularly, compound <strong>7bb</strong> demonstrated superior potency against MDA-MB-231 cells and A549 cells, with half maximal inhibitory concentration (IC₅₀) values of 4.286 and 4.720 μM, respectively, compared to the reference drug afatinib (IC₅₀ = 7.640 and 5.173 μM, respectively). This study provides valuable insights for the development of novel antitumor agents based on the 4-aminoquinazoline scaffold.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101770"},"PeriodicalIF":3.2,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}