Journal of the Indian Chemical Society最新文献

{"title":"Fabrication of CoFe2O4/PANI nanocomposite modified glassy carbon electrode for the electrochemical determination of paracetamol","authors":"Khush bakht ,&nbsp;Albandari .W. Alrowaily ,&nbsp;B.M. Alotaibi ,&nbsp;Abdelaziz Gassoumi ,&nbsp;Haifa A. Alyousef ,&nbsp;Hidayath Mirza ,&nbsp;Abhinav Kumar","doi":"10.1016/j.jics.2025.102080","DOIUrl":"10.1016/j.jics.2025.102080","url":null,"abstract":"<div><div>Paracetamol is recognized for its analgesic (pain reliever) and antipyretic (fever reducer) characteristics and function as a safer alternative to painkillers. An overdose of paracetamol and prolonged usage might result in considerable health issue in individuals. It is crucial to note its existence within the body, as well as in pharmaceutical preparations and dietary sources. A modified glassy carbon electrode (GCE) was produced by hydrothermally synthesizing a nanocomposite of CoFe₂O₄ and polyaniline (PANI). Brauner-Emmett-Teller (BET), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Energy Dispersive X-ray (EDX) analysis were used to illustrate the structure, composition, surface area and morphology of the CoFe₂O₄/PANI nanocomposite. The electrochemical sensing performance towards paracetamol and the stepwise construction method of the CoFe₂O₄/PANI/GCE electrode were assessed by square wave voltammetry (SWV). The experimental tests demonstrated that redox process of paracetamol was governed by adsorption control. The CoFe₂O₄/PANI/GCE demonstrated relationship to paracetamol within the concentration of 30–200 μM in SWV and linear range for SWV was determined to be 30–200 μM and limit of detection (LOD) for SWV was known to be 0.075 μM. The promising electrochemical response of the CoFe₂O₄/PANI composite indicates its potential for future development of selective and highly sensitive sensor platforms for paracetamol detection in clinical and pharmaceutical applications.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102080"},"PeriodicalIF":3.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable remediation of mixed heavy metals using hydrothermal and in-situ synthesis of Mg/Al-LDHs","authors":"John Karl Exiomo Macrohon ,&nbsp;Jin-Wei Zhang ,&nbsp;Muhammad Al Kholif ,&nbsp;Huan-Ping Chao","doi":"10.1016/j.jics.2025.102088","DOIUrl":"10.1016/j.jics.2025.102088","url":null,"abstract":"<div><div>This study explores the comparative efficacy of magnesium-aluminum/layered double hydroxides (Mg/Al-LDHs) synthesized via hydrothermal and in situ methods for the simultaneous removal of Cu(II), Pb(II), and Cr(VI) from aqueous solutions. The LDHs before and after adsorption were thoroughly characterized using SEM, XRD, FTIR, BET surface area analysis, XPS, and zeta potential measurements. The results demonstrated that hydrothermally synthesized Mg/Al-LDHs exhibited enhanced structural ordering and superior crystallinity, as evidenced by sharp and intense XRD peaks and increased BET surface area, and higher adsorption capacities, 240 mg/g for Cu(II), 512 mg/g for Pb(II), and 484 mg/g for Cr(VI), achieving equilibrium within 60 min. Adsorption kinetics followed a pseudo-second-order model, and equilibrium data were best described by the Langmuir isotherm, indicating a monolayer chemisorption process. In contrast, the in situ synthesis method proved advantageous in operational simplicity and reagent efficiency, achieving 100 % Pb(II) and &gt;80 % Cu(II) and Cr(VI) removal under alkaline conditions. Mechanistic analysis suggested that adsorption involved surface complexation, ion exchange, and surface precipitation. Furthermore, the adsorption of Cu(II) was only marginally affected by changes in pH, with a slight increase in capacity observed at higher pH levels. In contrast, Pb(II) showed a pronounced rise in adsorption with increasing pH, while Cr(VI) displayed the opposite behavior, with its adsorption decreasing as pH increased. These results demonstrate that optimizing LDH mineral structure enhances heavy metal uptake through improved stability and surface reactivity, supporting the development of high-performance, reusable adsorbents for sustainable wastewater remediation.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102088"},"PeriodicalIF":3.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent effects, solvation, and thermodynamic properties of isoniazid in alcohol-water solutions at various temperatures","authors":"Adel Noubigh ,&nbsp;Abdalazeem A. Omar ,&nbsp;Manef Abderrabba","doi":"10.1016/j.jics.2025.102086","DOIUrl":"10.1016/j.jics.2025.102086","url":null,"abstract":"<div><div>The KAT-LSER model and inverse Kirkwood-Buff integrals (IKBI) were used to analyze isoniazid (INH) solubility in methanol (MeOH), ethanol (EtOH), and 2-propanol (2-PrOH) mixtures with water. Solvent polarity, cavity term, and hydrogen bond basicity significantly influenced solubility. Preferential solvation parameters (<span><math><mrow><msub><mrow><mi>δ</mi><mi>x</mi></mrow><mrow><mn>1</mn><mo>,</mo><mtext>INH</mtext></mrow></msub></mrow></math></span>) varied with alcohol content, showing positive values in water-rich blends and negative values otherwise. However, |δ<em>x</em>_1,INH| was less than 1 × 10⁻², limiting the application of preferential solvation theory. INH was preferentially solvated by water in mixtures with sufficient alcohol content. Thermodynamic analysis, including enthalpy, Gibbs free energy, and entropy, revealed enthalpy-driven mechanisms governing INH solubility. This study elucidates INH solubility behavior, crucial for pharmaceutical and personal care applications.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 10","pages":"Article 102086"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of iron concentration on the structural and optical properties of iron lead sulphide thin films","authors":"Joseph Onyeka Emegha ,&nbsp;Ali El-Rayyes ,&nbsp;Yahaya Saadu Itas ,&nbsp;Mayeen Uddin Khandaker","doi":"10.1016/j.jics.2025.102085","DOIUrl":"10.1016/j.jics.2025.102085","url":null,"abstract":"<div><div>The article reports on the synthesis of iron-lead sulphide (<span><math><mrow><msub><mtext>Fe</mtext><mi>x</mi></msub><msub><mtext>Pb</mtext><mrow><mn>1</mn><mo>−</mo><mi>x</mi></mrow></msub><mi>S</mi></mrow></math></span>) thin films using the chemical bath deposition (CBD) technique. X-ray diffraction analysis confirmed that the deposited films were polycrystalline, exhibiting a strong (200) peak orientation. However, increasing iron incorporation led to a decrease in the average crystallite size from 47.4 to 22.9 nm. Scanning electron microscopy (SEM) revealed a variety of randomly distributed nanostructures across the films. Furthermore, the optical transmittance increased from 60 % to 80 % with an increase in iron concentrations, while the optical band gap varied from 1.86 to 2.25 eV. The optical analysis reveals that as iron concentration increases, the refractive index rises from 1.95 to 2.53. The real dielectric constant (Ɛᵣ) shifts from 3.76 to 6.48, while the imaginary dielectric constant (Ɛᵢ) changes from 0.03 to 0.13 respectively. These results indicate that the synthesized iron-lead sulphide thin films may be suitable for several optoelectronic applications.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 10","pages":"Article 102085"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable pathways to 2-Aminothiazoles: FeNPs/C as a novel magnetic nanocatalyst in aqueous media","authors":"Yang Fan","doi":"10.1016/j.jics.2025.102058","DOIUrl":"10.1016/j.jics.2025.102058","url":null,"abstract":"<div><div>The development of sustainable and environmentally friendly methods for synthesizing heterocyclic compounds is a crucial goal in modern organic chemistry. In this study, we introduce a novel green protocol for the synthesis of 2-aminothiazoles utilizing FeNPs/C, a magnetic nanocatalyst, in aqueous media. The FeNPs/C catalyst was characterized using FT-IR spectroscopy, while its morphology was assessed through SEM and TEM analyses. Our methodology employs readily available methyl carbonyl compounds and thioureas as starting materials, with <em>N</em>-bromosuccinimide (NBS) acting as a brominating agent to facilitate in situ cyclization under ambient conditions. The process achieved high yields ranging from 89 % to 96 % across 18 different substrates, demonstrating the broad applicability of this approach. Additionally, the catalyst exhibited excellent reusability, further enhancing its practicality. This work not only highlights the potential for scalable and eco-friendly production of thiazoles but also underscores the significant role of magnetic nanocatalysts in advancing green chemistry practices.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102058"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-driven interactions for enhanced corrosion resistance and chemical durability of metal alloys using triazole-based inhibitors: Synthesis, characterization, and computational perspectives","authors":"Noureddine Oufkir ,&nbsp;Malak Rehioui ,&nbsp;M’bark Elhaid ,&nbsp;Jihad Sebhaoui ,&nbsp;Achraf Hamik ,&nbsp;khalid Annour ,&nbsp;El Mokhtar Essassi ,&nbsp;Abdelkarim Chaouiki ,&nbsp;Fatima Lazrak","doi":"10.1016/j.jics.2025.102083","DOIUrl":"10.1016/j.jics.2025.102083","url":null,"abstract":"<div><div>This study investigates the potential of environmentally friendly corrosion inhibitors by focusing on two newly synthesized heterocyclic compounds, namely 5-pentylsulfanyl-3-phenyl-1,2,4-triazole (PTri-C₅H₁₁) and 5-pentylsulfanyl-3-undecyl-1,2,4-triazole (UTri-C₅H₁₁). These novel 1,2,4-triazole-5-thione derivatives were synthesized via solid-liquid phase transfer catalysis at ambient temperature conditions. The synthesis involved the alkylation of precursor triazole-thione compounds using iodopentane as the alkylating agent. The structural features of the synthesized compounds were confirmed by spectroscopic techniques, while their corrosion inhibition performance was evaluated through a combination of experimental and theoretical approaches. Results indicated that the inhibition efficiency followed the order: PTri-C₅H₁₁ &gt; UTri-C₅H₁₁, attributed to the donor-acceptor capability of the benzene ring and conjugated π-electrons forming coordination complexes with the carbon steel (CS) surface. At a concentration of 10⁻³ M, the tested compounds significantly enhanced corrosion resistance, achieving inhibition efficiencies of 92.98 % and 91.96 % for PTri-C₅H₁₁ and UTri-C₅H₁₁, respectively. To gain molecular-level insights, density functional theory (DFT) and density functional tight binding (DFTB) calculations were employed to explore the quantum chemical properties, adsorption characteristics, and interfacial interactions of the studied inhibitors Surface adsorption studies further revealed the formation of strong covalent bonds between the inhibitors and the CS surface, confirmed by the electron density analysis. Theoretical modeling showed that both inhibitors could adsorb in a parallel orientation via C, S, and N atoms, which maximizes the surface coverage. In this orientation, C–Fe, S–Fe, and N–Fe bond distances ranged, for both inhibitors, from 1.98 Å to 2.40 Å. Thus, experimental and theoretical findings are consistent, confirming that heteroatoms (1,2,4-triazole-5-thione group) and benzene ring (for PTri-C₅H₁₁) serve as primary adsorption sites on the CS surface. Overall, these findings demonstrate the promising potential of these 1,2,4-triazole derivatives as effective corrosion inhibitors for CS in acidic environments.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 10","pages":"Article 102083"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradation and phytotoxicity evaluation of textile azo dye effluent using alkaline protease enzyme from halophilic bacterium Halobacillus trueperi RRJS1","authors":"A. Harish ,&nbsp;R. Raja Jeya Sekar ,&nbsp;S.J. Sreeja ,&nbsp;S.M. Vijila ,&nbsp;V. Vidhya ,&nbsp;N. Ponmurugaraj","doi":"10.1016/j.jics.2025.102060","DOIUrl":"10.1016/j.jics.2025.102060","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Halophiles are salt loving bacteria and they are capable of producing extracellular enzymes. Nowadays, these enzymes are utilized as one of the main ingredients by the industries for manufacturing products and some environmental researchers exploit it for biodegradation studies. The present study highlights the unique biodegradation potential of Halobacillus trueperi RRJS1, a halophilic bacterium capable of producing highly active alkaline protease enzyme. It can withstand high salinity and can survive osmotic stress in the extreme salt concentration. Generally, halophiles produce more extracellular enzymes in high salt concentrations which are generally called as halozymes. Halophiles are salt loving bacteria that thrive in salt lakes and they are competent to produce more extracellular enzymes. These enzymes remain stable under these conditions. In the present research, the halophilic bacteria &lt;em&gt;H. trueperi&lt;/em&gt; RRJS1 is screened for production of alkaline protease enzyme and it was used for the degradation of highly toxic ingredients found in the textile azo dye effluent. The bacterial strain &lt;em&gt;H. trueperi&lt;/em&gt; RRJS1 was optimized with various physico - chemical parameters and maximum production of the alkaline protease enzyme was recorded at 40 °C and pH 7.5 (99.23 ± 0.42 U/ml); and in 6 % NaCl concentration (60.5 ± 1.28 U/ml). Among the nutritional sources, 1 % lactose and 1 % beef extract were induced maximum production of alkaline protease (24.7 ± 0.8 U/ml and 59.1 ± 0.56 U/ml). The physico-chemical parameters such as pH, BOD, COD, TDS, total hardness and chlorides were efficiently checked in the alkaline protease enzyme treated textile azo dye effluent. Degradation of textile azo-dye effluent by alkaline protease enzyme was conducted and highest percentage of degradation (84.30 %) was observed at alkaline protease enzyme produced by lactose. The GC-MS analysis of the alkaline protease treated textile azo dye effluent exhibited the presence of major and minor chemical compounds, and they were responsible for the degradation of azo dye components and 100 % disappearance of compounds in raw textile azo dye effluent was observed. The phytotoxicity studies on black gram &lt;em&gt;Vigna mungo&lt;/em&gt; revealed that the plants grown on the alkaline protease treated textile azo dye effluent enhanced seed germination (80 %), plumule (8.7 ± 1.35 cm) and radicle length (3.5 ± 1.80 cm) and less growth were observed in the raw textile azo dye effluent treated plants. The textile azo-dye effluent often encompassed with high concentration of salt and it could inhibit growth of the most microbial organisms in the polluted textile water. But, in this study, the extracellular protease enzyme from the halophilic bacteria &lt;em&gt;H. truperi&lt;/em&gt; RRJS1 exhibited reliable performance for the degradation of textile azo-dye effluent. This eco-friendly strain could effectively support sustainable textile waste water treatment strategies and remove the contaminant","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102060"},"PeriodicalIF":3.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization and biological evaluation of thymol-triazole conjugates as antiproliferative agents","authors":"Mohammad Mahboob Alam ,&nbsp;Syed Nazreen ,&nbsp;Serag Eldin I. Elbehairi ,&nbsp;Anas Alfarsi ,&nbsp;Ahmed A. Elhenawy ,&nbsp;Ali A. Shati ,&nbsp;Mohammad Y. Alfaifi ,&nbsp;Azizah M. Malebari ,&nbsp;Suada Alsaied Mohamed ,&nbsp;Mohammad Asad ,&nbsp;Muhammad Nadeem Arshad ,&nbsp;Mohamed G. Badrey","doi":"10.1016/j.jics.2025.102077","DOIUrl":"10.1016/j.jics.2025.102077","url":null,"abstract":"<div><div>The present work focuses on the preparation and antiproliferative activity of new thymol-triazole hybrids targeting thymidylate synthase. The structure of newly prepared hybrids was elucidated using NMR, IR and Mass spectroscopic techniques. The anticancer results showed that the thymol-triazole hybrids were most cytotoxic against HepG2 adenocarcinomas. Among the synthesized hybrids, compound <strong>12</strong> exhibited significant cytotoxic effect towards MCF-7, HepG2 and HCT-116 with IC₅₀ of 3.52, 1.02 and 4.12 μM, respectively as well as TS inhibition with IC₅₀ 0.21 μM. Furthermore, compound <strong>12</strong> arrested cell cycle at G2 phase by increasing cell population from 1.14 to 84.07 and suppressing G1 and S stages, with 96 % late apoptosis The biological results were also correlated with docking studies in which compound <strong>12</strong> displayed similar binding interaction to 5-florouracil. These results established compound <strong>12</strong> to be a potent TS inhibitor in cancer therapy.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 10","pages":"Article 102077"},"PeriodicalIF":3.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and properties of SiO2 wrapped γ-(CeLa)2S3 orange-red pigment by Stober method","authors":"Sirui Cheng ,&nbsp;Yueming Li ,&nbsp;Kai Li ,&nbsp;Fusheng Song ,&nbsp;Yi Sun ,&nbsp;Cheng Zhang ,&nbsp;Dawei Yang","doi":"10.1016/j.jics.2025.102057","DOIUrl":"10.1016/j.jics.2025.102057","url":null,"abstract":"<div><div>γ-(CeLa)₂S₃ is a newly developed rare earth inorganic orange-red pigment characterized by non-toxicity, bright coloration, and high weather resistance, though its thermal stability is limited to 350 °C. The Stober method provides an effective approach for enhancing its thermal resistance by applying a high-temperature-resistant coating to the pigment surface. In this study, commercially available orange-red γ-(CeLa)₂S₃ pigment was selected for investigation. The influence of solid content on the coating performance was examined, using CTAB as the dispersing agent, TEOS as the silicon source, anhydrous ethanol and pure water as co-solvents, and NH₃·H₂O to adjust the solution pH. Results indicate that when the solid content reaches 100 g, and the ethanol-water ratio and total volume remain constant, the coated pigment demonstrates superior thermal and acid resistance. The pigment retains its orange-red color (<em>L∗</em> = 45.40, <em>a∗</em> = 35.21, <em>b∗</em> = 47.80) after being calcined at 450 °C and exhibits no significant color alteration following 12 h immersion in 1.0 M hydrochloric acid.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 10","pages":"Article 102057"},"PeriodicalIF":3.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environment friendly synthesis of trifluoromethyl-festooned pyrazolo[1,5-a]pyrimidines with promising biological activity","authors":"Labet Bankynmaw Marpna ,&nbsp;Shunan Kaping ,&nbsp;Jayanti Datta Roy ,&nbsp;Jai Narain Vishwakarma","doi":"10.1016/j.jics.2025.102078","DOIUrl":"10.1016/j.jics.2025.102078","url":null,"abstract":"<div><div>A series of 7-(3,5-bis(trifluoromethyl)phenylpyrazolo[1,5-<em>a</em>]pyrimidine derivatives and 7-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-<em>a</em>]pyrimidine bearing trifluoromethyl group were efficiently synthesized in good to high yields by reacting the precursors (<em>E</em>)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(dimethylamino)prop-2-en-1-one (1) and (<em>E</em>)-3-(dimethylamino)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one (4) with aminopyrazoles under ultrasonic irradiation assisted by KHSO₄ at 60 °C in aqueous media. The structures of the compounds were confirmed by comprehensive structural and analytical characterization techniques (¹H NMR, ¹³C NMR, FT-IR, MS, HR-MS) with further validation by X-ray crystallographic analysis of a selected compound <strong>3a</strong>. Antimicrobial evaluation of the compounds revealed moderate to comparable activities with compounds <strong>3f</strong>, <strong>3i</strong>, <strong>6a</strong>, <strong>6c</strong> and <strong>6f</strong> as potential bioactive scaffolds.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 11","pages":"Article 102078"},"PeriodicalIF":3.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}