Journal of the Indian Chemical Society最新文献_第10页

Innovative UV derivative spectrophotometric method for simultaneous quantification of sulfadimethoxine and metronidazole 创新的紫外导数分光光度法同时定量磺胺二甲氧嘧啶和甲硝唑

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-03-06 DOI: 10.1016/j.jics.2025.101655

Larissa F. dos Santos , Lucas R.M. de Andrade , Teófilo F.M. Cardoso , Karen B.B. Caminha , Debora S. Pires , Erika P. Machado , Patrícia Severino , Marcos S. do Amaral , Eliana B. Souto , Najla M. Kassab

{"title":"Innovative UV derivative spectrophotometric method for simultaneous quantification of sulfadimethoxine and metronidazole","authors":"Larissa F. dos Santos , Lucas R.M. de Andrade , Teófilo F.M. Cardoso , Karen B.B. Caminha , Debora S. Pires , Erika P. Machado , Patrícia Severino , Marcos S. do Amaral , Eliana B. Souto , Najla M. Kassab","doi":"10.1016/j.jics.2025.101655","DOIUrl":"10.1016/j.jics.2025.101655","url":null,"abstract":"<div><div>This study developed and validated an analytical method based on derivative spectrophotometry for the simultaneous determination of sulfadimethoxine (SDM) and metronidazole (MTZ) in veterinary medicines, without the need for prior separation of the drugs. The method employed acetonitrile PA as the solvent at room temperature (25 ± 2 °C). MTZ was quantified using zero-order spectrophotometry at 320 nm, while SDM was determined using first-order spectrum at 266 nm, applying the zero-crossing technique. Analytical validation of the developed methods demonstrated robust results, with a correlation coefficient (r) > 0.990 in the concentration range of 3.0–21.0 μg mL<sup>−1</sup>, satisfactory limits of detection (MTZ: 0.21 μg mL<sup>−1</sup>; SDM: 0.17 μg mL<sup>−1</sup>) and quantification (MTZ: 0.63 μg mL<sup>−1</sup>; SDM: 0.51 μg mL<sup>−1</sup>), precision (relative standard deviation (RSD) < 1.9) and accuracy (recovery of 98.0–102.0 %). With operational simplicity and low cost, the developed method can be adopted for the routine analysis and quality control of medicines with a fix dose combination of these two drugs.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 5","pages":"Article 101655"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectroscopic, quantum computational investigation, light harvesting effect, In silco biological evaluations and molecular docking of novel pyrazole derivative - A potential anti-cancer agent 新型抗癌药物吡唑衍生物的光谱学、量子计算研究、光收集效应、硅生物学评价和分子对接

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-03-04 DOI: 10.1016/j.jics.2025.101657

P. Manikandan , M. Kumar , S. Kaleeswaran , S. Chithra , P. Swarnamughi , Mohammad Nikpassand , Jayavelu Udaya Prakash

{"title":"Spectroscopic, quantum computational investigation, light harvesting effect, In silco biological evaluations and molecular docking of novel pyrazole derivative - A potential anti-cancer agent","authors":"P. Manikandan , M. Kumar , S. Kaleeswaran , S. Chithra , P. Swarnamughi , Mohammad Nikpassand , Jayavelu Udaya Prakash","doi":"10.1016/j.jics.2025.101657","DOIUrl":"10.1016/j.jics.2025.101657","url":null,"abstract":"<div><div>The study's main objectives were to develop and synthesize hybrid pyrazole derivatives from 1,3-diphenyl-1H-pyrazole-4-carbaldehyde and assess their anticancer potential using molecular docking and DFT simulations. The DFT/B3LYP functional and 6-311+G (d, p) basis set were used to computationally describe the title chemical utilizing quantum mechanics method. Theoretical and experimental FT-IR studies were presented, and vibrational wavenumbers scaled. The research included a number of investigations, such as the examination of Frontier Molecular Orbital (FMO), the computation of the HOMO-LUMO energy gap, the Modeling of UV spectra using Time-Dependent Density Functional Theory (TD-DFT), and the assessment of Light Harvesting Efficiency (LHE). The properties of Natural Bond Orbital and Non-Linear Optical (NLO) were calculated. The title molecule's reactive sites were found using a multi-technical computational approach that included LOL for orbital distribution analysis, RDG analysis for examining non-covalent interactions and possible chemical reactivity hotspots, ELF for electron pairing and localization studies, charge transfer analysis for electron density shift examination, and MEP analysis for charge distribution mapping. Bioactivity evaluation indicated that the title molecule does conform to Lipinski's rule and is also quite good in terms of drug-likeness. Additionally, molecular docking investigations showed encouraging protein-ligand binding interactions, indicating that the substance has anticancer properties.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 5","pages":"Article 101657"},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and synthesis of benzylidene derivatives of curcumin, and evaluation of its antioxidant and chelating activities 姜黄素苄基衍生物的设计合成及其抗氧化和螯合活性的评价

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-03-03 DOI: 10.1016/j.jics.2025.101656

Chandani G. Halpani, Satyendra Mishra

{"title":"Design and synthesis of benzylidene derivatives of curcumin, and evaluation of its antioxidant and chelating activities","authors":"Chandani G. Halpani, Satyendra Mishra","doi":"10.1016/j.jics.2025.101656","DOIUrl":"10.1016/j.jics.2025.101656","url":null,"abstract":"<div><div>A number of curcumin derivatives, including 4-arylidene curcumin derivatives (4-arylidene-1,7-bisaryl-hepta-1,6-diene-3,5-diones), have been synthesised, purified and characterized. 4-(4-Hydroxy-3-methoxybenzylidene) curcumin <strong>(3;</strong> IC<sub>50</sub>; 35 ± 2.02), 4-(4-Hydroxy-benzylidene) curcumin <strong>(9;</strong> IC<sub>50</sub>; 42 ± 0.9), and 4-(3, 4, 5-trimethoxybenzylidene) curcumin <strong>(10;</strong> IC<sub>50</sub>; 58 ± 2.0), were found to have more antioxidant property than ascorbic acid (IC<sub>50</sub>; 111 ± 1.20), in the DPPH. Additionally, it was shown that 4-(4-Hydroxy-3-methoxybenzylidene) curcumin <strong>(3;</strong> IC<sub>50</sub>; 1.42 ± 0.11), 4-(4-Hydroxy-benzylidene) curcumin <strong>(9;</strong> IC<sub>50</sub>; 1.73 ± 0.026), and 4-(3, 4, 5-trimethoxybenzylidene) curcumin <strong>(10;</strong> IC<sub>50</sub>; 2.53 ± 0.145) exhibited higher antioxidant activity in ABTS assays than ascorbic acid (IC<sub>50</sub>; 2.53 ± 0.01). However, Fe<sup>2+</sup> chelating activity of 4-(4-Hydroxy-3-methoxybenzylidene) curcumin <strong>(3;</strong> 54 ± 3.5), 4-pyridilidene curcumin <strong>(4;</strong> 42 ± 1.8), 4-(4-Hydroxy-benzylidene) curcumin <strong>(9;</strong> 56 ± 0.1<strong>)</strong> and 4-(3, 4, 5-trimethoxybenzylidene) curcumin <strong>(10;</strong> 57 ± 2.4<strong>)</strong> exhibited better chelating activity than EDTA (35 ± 2.1). The structural activity relationship (SAR) has been used in this study to investigate the free radical scavenging and Fe<sup>2+</sup> chelating activity of curcumin and its derivatives. Studies on chelating and antioxidant activity has shown that this class of 4-arylidene curcumin derivatives has much better chelating and antioxidant activity than curcumin, the parent molecule.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 5","pages":"Article 101656"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZnFe2O4-SiO2@PC-Ni nanoparticles for one-pot, solvent-free synthesis of imidazo[1,2-a]pyridines by A3 coupling reactions under ultrasound conditions 超声条件下A3偶联反应制备咪唑[1,2-a]吡啶的纳米粒子ZnFe2O4-SiO2@PC-Ni

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-03-03 DOI: 10.1016/j.jics.2025.101653

Fadhil Faez Sead , Vicky Jain , Suhas Ballal , Abhayveer Singh , Sofia Gupta , Girish Chandra Sharma , Pushpa Negi Bhakuni , Mosstafa Kazemi , Ramin Javahershenas

{"title":"ZnFe2O4-SiO2@PC-Ni nanoparticles for one-pot, solvent-free synthesis of imidazo[1,2-a]pyridines by A3 coupling reactions under ultrasound conditions","authors":"Fadhil Faez Sead , Vicky Jain , Suhas Ballal , Abhayveer Singh , Sofia Gupta , Girish Chandra Sharma , Pushpa Negi Bhakuni , Mosstafa Kazemi , Ramin Javahershenas","doi":"10.1016/j.jics.2025.101653","DOIUrl":"10.1016/j.jics.2025.101653","url":null,"abstract":"<div><div>This study reports the development of ZnFe<sub>2</sub>O<sub>4</sub>–SiO<sub>2</sub>@PC-Ni magnetic nanoparticles as a novel by immobilizing phycocyanin onto magnetized silica and then immobilizing Ni (II) ions using nickel (II) chloride, the recyclable heterogeneous catalyst for the efficient one-pot synthesis of imidazo[1,2-<em>a</em>]pyridines via A3 coupling reactions under solvent-free ultrasound irradiation. Utilizing 2-aminopyridine, various aldehydes, and alkynes, the reactions were conducted solvent-free under ultrasound conditions, enhancing reaction rates and sustainability. The core-shell nanocomposite, comprising a ZnFe2O4 magnetic core, silica interlayer, and porous carbon-supported nickel shell, was characterized by XRD, TEM, BET, and VSM analyses. The synergistic effects of Ni active sites, high surface area, and magnetic retrievability enabled rapid catalytic activation of the three-component reaction between aldehydes, amines, and alkynes. Ultrasound irradiation significantly enhanced mass transfer and reaction kinetics, achieving 90–95 % yields within 10–20 min under mild conditions. The catalyst demonstrated exceptional stability, retaining >88 % activity over six cycles, and facile magnetic separation minimized metal leaching. This eco-friendly protocol eliminates toxic solvents, reduces energy consumption, and offers broad substrate scope, including aromatic, heteroaromatic, and aliphatic substrates. This work not only contributes a novel catalyst to the field of organic synthesis but also aligns with environmental directives by minimizing hazardous solvent use and employing energy-efficient reaction conditions.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 5","pages":"Article 101653"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size-tuned silver nanoparticles by a non-gassing electro-osmotic pump-driven microfluidic device 一种非气体电渗透泵驱动的微流控装置的尺寸调谐银纳米颗粒

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-02-28 DOI: 10.1016/j.jics.2025.101641

Vidhiben Dave , Sooraj Sreenath , Gopala Ram Bhadu , Nitin G. Borle , Govind Sethia , Rajaram K. Nagarale

{"title":"Size-tuned silver nanoparticles by a non-gassing electro-osmotic pump-driven microfluidic device","authors":"Vidhiben Dave , Sooraj Sreenath , Gopala Ram Bhadu , Nitin G. Borle , Govind Sethia , Rajaram K. Nagarale","doi":"10.1016/j.jics.2025.101641","DOIUrl":"10.1016/j.jics.2025.101641","url":null,"abstract":"<div><div>Silver nanoparticles (AgNPs) are extensively used in various fields, but conventional synthesis techniques often face limitations in achieving precise control over particle size and morphology. To address this challenge, we explored the use of a microfluidic approach for synthesizing size-tuned AgNPs. Scaling down the reactor dimensions provides better control of the process of AgNPs synthesis and enables a low consumption and a high conversion of the reagents. The study aimed to utilize non-gassing electro-osmotic pumps (EOPs) connected to a three-way Y-junctioned microfluidic device for achieving controlled nanoparticle synthesis. The EOP design features a silica frit sandwiched between two flow-through electrodes composed of an Ag–Fe–O composite material. Performance evaluations revealed that the electro-osmotic flux was linearly dependent on applied voltage, with a maximum flow rate of 175.16 μL min<sup>−1</sup> cm<sup>−2</sup> achieved at 5.0 V. Optimized device parameters demonstrated effective nanoparticle synthesis, producing uniform AgNPs with sizes ranging from 10 to 15 nm at the maximum flow rate. Furthermore, particle size was found to vary directly with the voltage applied to the individual pumps. The synthesized nanoparticles were extensively characterized, and a long-term stability study confirmed their dispersion remained aggregation-free over 210 days. This research highlights the successful integration of microfluidic technology and EOPs for controlled AgNP synthesis, offering a scalable and precise platform for applications requiring consistent nanoparticle size and stability.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 5","pages":"Article 101641"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effect of ZnO nanoparticles and benzyl piperazine on MWCNTs for anti-microbial activity and energy applications ZnO纳米颗粒和苄基哌嗪对MWCNTs的协同抑菌作用及其能源应用

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-02-28 DOI: 10.1016/j.jics.2025.101652

Amna Ishtiaq , Saghir Hussain , Tanveer Farid , Khalid Mahmood , Hafiza Farhat , Javaria , Arshia Iqbal , Sidra Aslam , Muhammad Safdar

{"title":"Synergistic effect of ZnO nanoparticles and benzyl piperazine on MWCNTs for anti-microbial activity and energy applications","authors":"Amna Ishtiaq , Saghir Hussain , Tanveer Farid , Khalid Mahmood , Hafiza Farhat , Javaria , Arshia Iqbal , Sidra Aslam , Muhammad Safdar","doi":"10.1016/j.jics.2025.101652","DOIUrl":"10.1016/j.jics.2025.101652","url":null,"abstract":"<div><div>Zinc oxide/multi-walled carbon nanotubes (ZnO/MWCNTs) Benzyl piperazine nanocomposite fabricating and its potential applications for water splitting and antimicrobial activity evaluation are discussed in this research. Green synthesis of zinc oxide nanoparticles (ZnO NPs) was done by aqueous cinnamon bark powder using a hydrothermal method on the surface of multi-walled carbon nanotubes-benzyl piperazine derivative to form the nanocomposite. Compared to bare zinc oxide nanoparticles, the nanocomposite shows superior antioxidant and antibacterial activities. Time leads to enhancing antioxidant properties; at 1 min, an increased amount was recorded in a crude extract of AM-2 for 30 min. The MFC values of our crude extracts have shown up to 10 mm and more than 10 mm zone of inhibition against <em>S. aureus, P. aeruginosa, S. typhimurium, B. subtilis</em> and <em>E. coli</em> at concentrations of 60μL/disc. The zinc oxide/multi-walled carbon nanotubes (ZnO/MWCNTs) piperazine nanocomposite, when subjected to a current density of 10 mA cm<sup>−2</sup>, the electrode exhibited the optimal overpotential (330 mV) for oxygen evolution reaction (OER) and (278 mV) for hydrogen evolution reaction (HER). These findings imply that the zinc oxide/multi-walled carbon nanotubes (ZnO/MWCNTs) benzyl piperazine nanocomposite has high bioactive effectiveness and significant promise for water-splitting applications.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 4","pages":"Article 101652"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel counter ion exchanged in DSP-[CuX(phen)2].ClO4 complexes family and their antimicrobial/anti-inflammatory/COX-LOX evaluations DSP-[CuX(phen)2]中新型反离子交换。ClO4配合物家族及其抗菌/抗炎/COX-LOX评价

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-02-27 DOI: 10.1016/j.jics.2025.101651

Anas AlAli , Khalil Shalalin , Hussien Khamees , Lubna Abdallah , Rafa Almeer , Abdelkader Zarrouk , Ismail Warad , Shaukath Ara Khanum

{"title":"Novel counter ion exchanged in DSP-[CuX(phen)2].ClO4 complexes family and their antimicrobial/anti-inflammatory/COX-LOX evaluations","authors":"Anas AlAli , Khalil Shalalin , Hussien Khamees , Lubna Abdallah , Rafa Almeer , Abdelkader Zarrouk , Ismail Warad , Shaukath Ara Khanum","doi":"10.1016/j.jics.2025.101651","DOIUrl":"10.1016/j.jics.2025.101651","url":null,"abstract":"<div><div>Using ClO<sub>4</sub><sup>−</sup> anion, the X<sup>−</sup> counter ions of the monocation [CuX (phen)<sub>2</sub>]. X complexes (X = Br, Cl, and NO<sub>3</sub>) have been nucleophilically substituted resulting in three new ClO<sub>4</sub><sup>−</sup>/X<sup>−</sup> hybrids [CuX (phen)<sub>2</sub>].ClO<sub>4</sub> salt complexes <strong>1</strong>–<strong>3</strong> for their structural and pharmacological purposes. This substitution reaction is being monitored by IR, UV–Vis, and EDX. Moreover, the desired hybrid complexes <strong>1</strong>–<strong>3</strong> were analyzed using a wide variety of analytical tools, such as EDX, X-ray, MS, FT-IR, UV–Vis., SEM, CHN-EA, and TG/DTG. Both complex <strong>1</strong> and complex <strong>2</strong> showed a high distortion square pyramid (DSP) structure centered on Cu(II) when X-ray diffraction was performed, XRD/HSA-interactions reflected the existence of several synthons mainly formed <em>via</em> C<sub>ph</sub>-H ….OClO<sub>3</sub> H-bond interactions. The complexes with the most stable thermal behavior were reflected by the TG/DTG; meanwhile, only two steps of degradation were recorded. All the complexes showed high activity against eight types of bacteria strains; in most cases, the complexes were more active than the Gentamicin universal antibiotic. Additionally, the complexes' inflammation ability <em>via</em> cyclooxygenase (COX) and lipoxygenase (LOX) enzyme inhibitions have been recorded, and then the molecular docking using suitable enzymes was served to explain the experimental anti-inflammatory results.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 4","pages":"Article 101651"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural, Electrical and Dielectric Characteristics of polypyrrole doped polyvinyl alcohol / carboxymethyl cellulose blended polymer 掺杂聚吡咯的聚乙烯醇/羧甲基纤维素共混聚合物的结构、电气和介电特性

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-02-26 DOI: 10.1016/j.jics.2025.101648

A.M. El-naggar , Lamya A. Alsulaymani , A.M. Kamal , A.A. Albassam , A.M. Aldhafiri , Mohamed Bakr Mohamed

{"title":"Structural, Electrical and Dielectric Characteristics of polypyrrole doped polyvinyl alcohol / carboxymethyl cellulose blended polymer","authors":"A.M. El-naggar , Lamya A. Alsulaymani , A.M. Kamal , A.A. Albassam , A.M. Aldhafiri , Mohamed Bakr Mohamed","doi":"10.1016/j.jics.2025.101648","DOIUrl":"10.1016/j.jics.2025.101648","url":null,"abstract":"<div><div>In order to establish polymeric nanocomposite films, polypyrrole (PPy) has been mixed with carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVA), which have been utilized as polymeric matrices in capacitive energy storage filed. X-ray diffraction and scanning electron microscopy equipment were utilized to examine the structure and morphology of all PVA/CMC/x wt % PPy blended polymers. Complex electric modulus, dielectric constant, ac conductivity, complex impedance spectroscopy, and temperature-and frequency-dependent PPy doping levels were investigated in PVA/CMC/x wt % PPy samples. Sample with <em>x</em> = 0.1 has the greatest achievable energy density (<em>U</em>) value and maximum ac conductivity. Elevating the temperature for all samples enhanced the values of <em>U</em>. The AC conductivity's conduction mechanism is also determined. The PPy doping and the temperatures varied the relaxation times of all samples. Cole-Cole figures of all samples are influenced by the amount of PPy and the temperatures. The doped samples exhibit higher dc conductivities than the undoped samples at temperatures up to 330 K. Samples with x = 0.2 and x = 0.4 exhibited greater conductivity than the pure sample above this temperature range. Depending on the temperature range, the unfilled blend range has two activation energies (<em>E</em><sub>a</sub>) values of 0.12 eV and 0.57 eV. The <em>E</em><sub>a</sub> values of the host polymer change in response to the doping amount of PPy. These results indicate that the produced samples could be used for capacitive energy storage.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 4","pages":"Article 101648"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing a β-nitrostyrene derived chitosan Schiff base with potent antimicrobial and antioxidant activities and drug delivery applications β-硝基苯乙烯衍生壳聚糖希夫碱的设计，具有有效的抗菌和抗氧化活性和药物传递应用

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-02-26 DOI: 10.1016/j.jics.2025.101650

Suryambika Arya, Ruchi Chawla, P.K. Dutta

{"title":"Designing a β-nitrostyrene derived chitosan Schiff base with potent antimicrobial and antioxidant activities and drug delivery applications","authors":"Suryambika Arya, Ruchi Chawla, P.K. Dutta","doi":"10.1016/j.jics.2025.101650","DOIUrl":"10.1016/j.jics.2025.101650","url":null,"abstract":"<div><div>A novel reaction between chitosan and β-nitrostyrene was carried out to obtain Schiff base based chitosan derivative β-NS-CS via aza-Michael addition followed by elimination reaction (retro-aza-Henry type process). FT-IR, P<strong>-</strong>XRD, <sup>1</sup>H NMR and FE-SEM analyses supported the result. With the FT-IR stretches at 1617 cm<sup>−1</sup>, the successful formation of imine bond (>C<img>N-) was verified. In case of P<strong>-</strong>XRD, we procured two additional peaks at 2θ = 21.3° and 2θ = 23.3° (other than that in chitosan) which indicated better crystalline behaviour of β-NS-CS in comparison to chitosan. <sup>1</sup>H NMR signals in the aromatic region verified the thriving inclusion of <em>trans</em>-β-nitrostyrene derived moeity into chitosan backbone. The planar sheet-like and asymmetrical morphology of the β-NS-CS conjugate was exhibited by FE-SEM images. The derivative was further analysed by DLS (average particle size of β-NS-CS = 70 nm) and zeta potential (+41.9 mV) studies. In terms of biological applications, β-NS-CS showed implicit antimicrobial property when studied against gram negative bacteria (<em>Escherichia coli</em>), gram positive bacteria (<em>Bacillus subtillis</em>) and fungus (<em>Aspergillus niger</em>). It also showed good antioxidant activity against DPPH and ABTS antioxidant assessment i.e, 22.5 % and 80.5 % radical scavenging potential respectively. It also proved to be an efficient candidate as a drug carrier having drug encapsulation efficiency of 80 % with quercetin as a model drug. The drug release kinetics was found to be 81 % at pH = 5.0 and 7 % at pH = 7.4 after 96 h. Hence, β-NS-CS is expected to find potential applications in biological and medicinal field in future.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 4","pages":"Article 101650"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study involving stochastic principle in elucidating discrete and average transformation paths in Xenon doped Argon cluster 用随机原理解释掺氙氩团簇离散和平均转变路径的研究

IF 3.2 4区化学

Journal of the Indian Chemical Society Pub Date : 2025-02-25 DOI: 10.1016/j.jics.2025.101626

Rijaul Haque Mirdha , Pinaki Chaudhury

{"title":"A study involving stochastic principle in elucidating discrete and average transformation paths in Xenon doped Argon cluster","authors":"Rijaul Haque Mirdha , Pinaki Chaudhury","doi":"10.1016/j.jics.2025.101626","DOIUrl":"10.1016/j.jics.2025.101626","url":null,"abstract":"<div><div>We in this work would like to examine the efficacy of stochastic principles in finding out isomerization transformation pathways in Argon cluster doped with Xenon impurity. The potential holding the clusters together involves van der Waals interaction and with a dopant atom we have to adequately incorporate in the potential energy separate interactions due to <span><math><mrow><mi>A</mi><mi>r</mi><mo>−</mo><mi>A</mi><mi>r</mi></mrow></math></span> and <span><math><mrow><mi>A</mi><mi>r</mi><mo>−</mo><mi>X</mi><mi>e</mi></mrow></math></span> units. As these surfaces are extremely rugged and quite shallow at certain regions the possibility of existence of multiple structures is huge. If one wants to see whether sets of isomers are connected to each other by a transition state one has to do a complete transformation path profile evaluation. In this work <span><math><mrow><mi>A</mi><msub><mrow><mi>r</mi></mrow><mrow><mn>18</mn></mrow></msub><mi>X</mi><mi>e</mi></mrow></math></span> is taken as the system of choice and isolation of a number of discrete transforming pathways connecting two minima where identified. Having obtained these discrete set of paths we have looked into the issue of constructing an average path of transformation and also to see how this average path changes with temperature.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 4","pages":"Article 101626"},"PeriodicalIF":3.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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