Sustainable pathways to 2-Aminothiazoles: FeNPs/C as a novel magnetic nanocatalyst in aqueous media

Abstract

The development of sustainable and environmentally friendly methods for synthesizing heterocyclic compounds is a crucial goal in modern organic chemistry. In this study, we introduce a novel green protocol for the synthesis of 2-aminothiazoles utilizing FeNPs/C, a magnetic nanocatalyst, in aqueous media. The FeNPs/C catalyst was characterized using FT-IR spectroscopy, while its morphology was assessed through SEM and TEM analyses. Our methodology employs readily available methyl carbonyl compounds and thioureas as starting materials, with N-bromosuccinimide (NBS) acting as a brominating agent to facilitate in situ cyclization under ambient conditions. The process achieved high yields ranging from 89 % to 96 % across 18 different substrates, demonstrating the broad applicability of this approach. Additionally, the catalyst exhibited excellent reusability, further enhancing its practicality. This work not only highlights the potential for scalable and eco-friendly production of thiazoles but also underscores the significant role of magnetic nanocatalysts in advancing green chemistry practices.