{"title":"Intraocular Lens Stability in Eyes With ⩾ 30 mm Axial Length With Two Sizes of Capsular Tension Rings.","authors":"Xiaojing Liu, Yue Zhang, Xin Zhang, Xiaowei Xu, Chi Zhang, Yanhui Xu, Yuhan Zhen, Xinran Zhai, Zhimin Chen","doi":"10.3928/1081597X-20251125-05","DOIUrl":"https://doi.org/10.3928/1081597X-20251125-05","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of implantation of two sizes of capsular tension rings (CTRs) on intraocular lens (IOL) stability in patients with cataract who have an axial length (AL) of 30 mm or greater.</p><p><strong>Methods: </strong>This prospective randomized controlled study included 120 eyes (AL ⩾ 30 mm) undergoing phacoemulsification and IOL implantation, randomized into three groups (n = 40 each): large group (CTR1311 [Eyebright Medical Technology]: 13 × 11 mm), small group (CTR1210 [Eyebright Medical Technology]: 12 × 10 mm), and control group (no CTR). Postoperative assessments (1 day and 1, 3, and 6 months) included uncorrected and corrected distance visual acuity (UDVA/CDVA), area of continuous curvilinear capsulorhexis (ACCC), IOL tilt/decentration, intraocular pressure (IOP), and corneal endothelial cell (CEC) counts.</p><p><strong>Results: </strong>All groups had improved UDVA/CDVA postoperatively (<i>P</i> > .05). At 3 and 6 months, horizontal IOL tilt/decentration differed significantly among groups (<i>P</i> < .05). The control group had greater tilt at 3 and 6 months versus 1 week (<i>P</i> < .05) and the small group at 3 months versus 1 week (<i>P</i> < .05). All groups had lower ACCC at 6 months versus baseline (<i>P</i> < .05). The large group had the highest posterior capsule-IOL attachment rate (85%) and the lowest posterior capsular opacity rate (5% vs 12.5% in the small group and 22.5% in the control group). Postoperative IOP/CEC showed no intergroup differences (<i>P</i> > .05).</p><p><strong>Conclusions: </strong>In eyes with AL of 30 mm of greater, the CTR1311 more fully supports the lens sac, reduces its shrinkage, stabilizes the IOL, and thus obtains better visual quality. However, the study had limited power (61%) due to the smaller sample size. Therefore, although selecting a large CTR in such patients is recommended based on our findings, further validation in larger studies is warranted.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 3","pages":"e198-e207"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply: Optimizing Keratorefractive Lenticule Extraction: Addressing Centration, Epithelial Remodeling, and Nomogram Refinement.","authors":"Majid Moshirfar, Mina M Sitto, Phillip C Hoopes","doi":"10.3928/1081597X-20260203-01","DOIUrl":"https://doi.org/10.3928/1081597X-20260203-01","url":null,"abstract":"","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 3","pages":"e286-e287"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sterile Anterior Segment Inflammation Associated With Sulcus-Supported Phakic IOL Surgery.","authors":"Yishan Qian, Lingling Niu, Xianglong Yi, Hongyu Kong, Jia Huang, Zhiqiang Yu, Peijun Yao, Ti Wang, Meiyan Li, Xingtao Zhou, Xiaoying Wang","doi":"10.3928/1081597X-20260112-04","DOIUrl":"https://doi.org/10.3928/1081597X-20260112-04","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the incidence, presentation, and outcomes of sterile anterior segment inflammation following sulcus-supported phakic IOL implantation (SASI-pIOL).</p><p><strong>Methods: </strong>The retrospective case series included consecutive patients diagnosed as having SASI-pIOL (early-onset: ⩽ 7 days; late-onset: > 7 days postoperatively) between July 2023 and July 2024 at two tertiary centers in China. All patients were followed up for at least 6 months after diagnosis.</p><p><strong>Results: </strong>SASI-pIOL occurred in 39 eyes (0.26%) out of 15,209 pIOL surgeries. Early-onset cases accounted for 26 eyes (66.7%), and late-onset for 13 eyes (33.3%). Anterior chamber inflammation and pIOL surface white deposits resolved completely with topical steroids. No eye lost one or more Snellen lines in corrected distance visual acuity. No significant changes were observed in intraocular pressure or endothelial cell density compared to baseline. Recurrence of white deposits on the pIOL occurred in 11 eyes (42.3%) in the early-onset group and 6 eyes (54.5%) in the late-onset group. A significant difference was observed in the proportion of early-onset versus late-onset SASI-pIOL cases relative to ophthalmic viscosurgical device use (<i>P</i> < .001, Fisher's exact test).</p><p><strong>Conclusions: </strong>SASI-pIOL is uncommon, responds well to topical corticosteroids, and is associated with favorable visual outcomes, yet requires long-term monitoring due to a notable recurrence rate.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 3","pages":"e248-e256"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arianna Grendele, Karl Anders Knutsson, Kenneth J Hoffer, Giorgio Paganoni, Giorgio Lari, Carlotta Senni, Catarina Coutinho, Giacomo Savini
{"title":"Validation of a Regression Formula to Predict Post-DMEK Keratometry and Improve IOL Power Calculation in Eyes Undergoing Phacoemulsification Combined With DMEK.","authors":"Arianna Grendele, Karl Anders Knutsson, Kenneth J Hoffer, Giorgio Paganoni, Giorgio Lari, Carlotta Senni, Catarina Coutinho, Giacomo Savini","doi":"10.3928/1081597X-20260112-05","DOIUrl":"https://doi.org/10.3928/1081597X-20260112-05","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the refractive accuracy of intraocular lens (IOL) power calculation in patients with Fuchs' endothelial dystrophy (FED) undergoing Descemet membrane endothelial keratoplasty (DMEK) combined with cataract surgery (triple DMEK), using an estimated keratometry value developed to minimize postoperative hyperopic outcomes.</p><p><strong>Methods: </strong>Thirty-one eyes of 31 phakic patients with FED and corneal edema undergoing triple DMEK were included. Preoperative assessments included optical biometry with the IOLMaster 700 (Carl Zeiss Meditec AG) and anterior segment optical coherence tomography (AS-OCT) with the MS-39. IOL power was calculated with 7 formulas (Barrett Universal II, EVO 2.0, Haigis, Hoffer QST, Holladay 1, Kane, and SRK/T) using both the measured preoperative keratometry and an estimated postoperative keratometry derived from a regression model (ΔK = 5.281 + 1.926 × R<sub>ant</sub> - 1.493 × R<sub>post</sub>). The spherical equivalent prediction error (SEQ-PE) was assessed at 6 months and analyzed using Eyetemis.</p><p><strong>Results: </strong>Substituting the estimated keratometry for the measured keratometry halved the hyperopic SEQ-PE across all formulas (from > +1.00 D to approximately +0.50 D), improving both trueness and overall accuracy. Although precision (ie, standard deviation) also improved, this change was not statistically significant. The formulas achieving the highest percentage of eyes with SEQ-PE less than ±0.50 D were Haigis and EVO 2.0 (52% each), followed by Hoffer QST (48%).</p><p><strong>Conclusions: </strong>Using estimated keratometry values derived from a regression model significantly improves refractive outcomes in patients with FED undergoing triple DMEK, reducing the risk of hyperopic surprises following surgery.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 3","pages":"e257-e263"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenkai Huang, Chenyuan Zhu, Xuechuan Miao, Er Mo, Zhexuan Liu, Jin Li, Junyong Cai
{"title":"Effect of Anterior Capsule Polishing on the Capsule-IOL Complex in Patients With Normal Axial Length: A Prospective Randomized Controlled Trial.","authors":"Wenkai Huang, Chenyuan Zhu, Xuechuan Miao, Er Mo, Zhexuan Liu, Jin Li, Junyong Cai","doi":"10.3928/1081597X-20260112-10","DOIUrl":"https://doi.org/10.3928/1081597X-20260112-10","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of anterior capsule polishing (ACP) on postoperative formation of the capsule-intraocular lens (C-IOL) complex in patients with cataract who have normal axial length.</p><p><strong>Methods: </strong>In this prospective randomized controlled trial, patients were assigned to either 360° ACP or no polishing. Primary outcomes (capsular bend index [CBI], adhesion index [AI], and continuous curvilinear capsulorhexis diameter [CCCD]) and secondary outcomes (IOL tilt and decentration) were quantitatively assessed at 1 week, 1 month, and 3 months postoperatively using 14-meridian swept-source optical coherence tomography (SS-OCT) (CASIA 2; Tomey). Additional secondary outcomes were root mean square (RMS), corrected distance visual acuity (CDVA), and spherical equivalent refraction (SER).</p><p><strong>Results: </strong>Forty-five eyes were enrolled (23 ACP, 22 control), and 40 (20 per group) completed a 3-month follow-up. At 3 months, the ACP group showed lower CBI (3.16 vs 3.68; <i>P</i> = .001) and AI (0.00 vs 0.32; <i>P</i> = .023), larger CCCD (5.30 vs 5.04 mm; <i>P</i> = .025), and less CCCD contraction (0.11 vs 0.22 mm; <i>P</i> = .034). Between-visit changes in CBI and AI did not differ between groups. Vertical tilt and its RMS were greater with ACP (<i>P</i> = .012 and .009, respectively), whereas horizontal tilt, decentration, CDVA, and SER were comparable.</p><p><strong>Conclusions: </strong>ACP slows early C-IOL structural maturation (reduced capsular-bend kinetics and delayed capsule-IOL adhesion) without compromising early refractive stability and stabilizes the capsulorhexis, but increases vertical IOL tilt. These findings support selective use in eyes prone to contraction and caution when precise IOL alignment is required.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 3","pages":"e264-e272"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multimodal Predictive Modeling for Visual Quality Recovery After Keratorefractive Lenticule Extraction.","authors":"Qi Wan, Li Chen, Jing Tang, Ying-Ping Deng, Ke Ma","doi":"10.3928/1081597X-20260112-03","DOIUrl":"https://doi.org/10.3928/1081597X-20260112-03","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the factors influencing visual quality recovery after keratorefractive lenticule extraction (KLEx) and to establish a predictive model for postoperative visual quality using multimodal data integration.</p><p><strong>Methods: </strong>A prospective, non-interventional single-center study was conducted on 210 eyes from 105 myopic patients undergoing KLEx surgery. Preoperative and postoperative visual quality was assessed using the Objective Scatter Index (OSI). High-precision segmentation of posterior lenticule scanning images was performed using a U-net-based deep learning model to extract radiomics features. These features, along with clinical data, surgical parameters, corneal topography, and biomechanics, were integrated into machine learning models for predicting OSI at 1 day and 1 week postoperatively.</p><p><strong>Results: </strong>The study found that 30.95% (65/210) of eyes experienced poor early visual recovery. Significant differences in spherical equivalent, corneal curvature, and cutting depth were observed between good and poor visual quality groups. The ExtraTrees model demonstrated high efficacy in predicting OSI on the first postoperative day (area under the curve [AUC] = 0.96), whereas the AdaBoost model excelled at 1 week (AUC = 0.99). Regression models RidgeCV and LassoLarsIC performed best for predicting OSI values at 1 day and 1 week, respectively. Radiomics features such as original topology Gaussian Curvature Min and original gldm Dependence Variance were significantly correlated with the OSI.</p><p><strong>Conclusions: </strong>The study establishes a predictive framework that integrates intraoperative scanning image features, corneal biomechanics, and densitometry parameters, offering a quantitative basis for personalized surgical planning. The synergistic use of radiomics and clinical parameters can pre-identify high-risk patients, optimize surgical settings, and improve postoperative visual quality.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 3","pages":"e235-e247"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum for \"The Impact of Different Rose Bengal Formulations on Corneal Thickness and the Efficacy of Rose Bengal/Green Light Corneal Cross-Linking in the Rabbit Eye\".","authors":"","doi":"10.3928/1081597X-20260108-01","DOIUrl":"https://doi.org/10.3928/1081597X-20260108-01","url":null,"abstract":"","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 2","pages":"e196"},"PeriodicalIF":3.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shenglong Luo, Kuangching Lin, Xuefei Li, Xin Zhang, Lvfu He, Ahmed Elsheikh, Fangjun Bao, Meixiao Shen, Shihao Chen, Fan Lu, Junjie Wang
{"title":"Texture-based Analysis of Corneal Dynamics for the Detection of Forme Fruste Keratoconus.","authors":"Shenglong Luo, Kuangching Lin, Xuefei Li, Xin Zhang, Lvfu He, Ahmed Elsheikh, Fangjun Bao, Meixiao Shen, Shihao Chen, Fan Lu, Junjie Wang","doi":"10.3928/1081597X-20251125-02","DOIUrl":"https://doi.org/10.3928/1081597X-20251125-02","url":null,"abstract":"<p><strong>Purpose: </strong>To propose CVS-omics, a radiomics framework using Corvis ST (CVS) (Oculus Optikgeräte GmbH) imaging and machine learning, for precise identification of forme fruste keratoconus (FFKC), a subtle corneal condition often undetected by conventional diagnostics.</p><p><strong>Methods: </strong>A total of 410 eyes were evaluated, including 265 normal eyes and 145 FFKC eyes. Texture features through radiomics were extracted from CVS images acquired at three key deformation phases: initial state, first applanation, and maximum deformation. These features were used to train three machine learning models (Random Forest [Minitab, Inc], C5.0 [RuleQuest Research], and XGBoost (extreme Gradient Boosting) on 328 eyes, with testing conducted on 82 eyes. Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis and compared with conventional biomechanical parameters.</p><p><strong>Results: </strong>The CVS-omics Random Forest model achieved superior diagnostic performance (area under the curve (AUC) = 0.989, sensitivity = 0.931, specificity = 0.962, accuracy = 0.951), significantly outperforming traditional CVS parameters (best AUC = 0.764). Models trained on features from three deformation phases showed higher diagnostic accuracy than those based on a single phase. Other models demonstrated high generalizability of dynamic radiomics features (XGBoost and C5.0 AUC > 0.83).</p><p><strong>Conclusions: </strong>CVS-omics effectively detects subtle characteristic alterations in FFKC eyes with superior accuracy compared to conventional biomechanical parameters. This texture feature approach shows promise as a non-invasive clinical tool for FFKC detection and timely intervention.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 2","pages":"e141-e150"},"PeriodicalIF":3.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel David, Michael Mimouni, Guy Kleinmann, Or Gil, Lee Nussbaum, Shalev Fried, Irina S Barequet
{"title":"Rare but Serious: Infectious Keratitis After Femtosecond Laser-Assisted Arcuate Keratotomies in Cataract Surgery: A Case Series and Review of Literature.","authors":"Daniel David, Michael Mimouni, Guy Kleinmann, Or Gil, Lee Nussbaum, Shalev Fried, Irina S Barequet","doi":"10.3928/1081597X-20251125-01","DOIUrl":"https://doi.org/10.3928/1081597X-20251125-01","url":null,"abstract":"<p><strong>Purpose: </strong>To present five cases of infectious keratitis following femtosecond laser-assisted cataract surgery combined with laser arcuate keratotomies (FLACS-AK).</p><p><strong>Methods: </strong>This was a retrospective review of the medical records of five patients who developed infectious keratitis after FLACS-AK, including medical history, clinical findings, surgical details, microbiological culture results, and imaging. Review of the literature revealed only two other published cases describing infectious keratitis following FLACS-AK.</p><p><strong>Results: </strong>All patients underwent uneventful FLACS-AK in both eyes and later developed unilateral infectious keratitis at the arcuate keratotomy incision. One patient developed an early-onset, fulminant infection with cultures positive for <i>Pseudomonas aeruginosa</i>. Two patients presented with late-onset, milder infections, with negative culture results. Two patients developed a very late-onset infection due to <i>P. aeruginosa</i>, with one of them requiring surgical intervention. All patients were also treated with fortified antibiotics. Four of five patients had good clinical and visual outcomes, whereas one patient suffered from devastating results.</p><p><strong>Conclusions: </strong>Infectious keratitis following FLACS-AK is a rare but potentially sight-threatening complication with variable onset and severity. Penetrating arcuate keratotomies may pose a higher risk of infection compared to intrastromal incisions, underscoring the need for careful surgical planning and long-term postoperative surveillance. Surgeons should therefore consider performing an intrastromal incision or, when applicable, a different method for arcuate correction.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 2","pages":"e189-e195"},"PeriodicalIF":3.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}