Patricia A Cavazos-Rehg, Xiao Li, Layna Paraboschi, Erin Kasson, Lucy Meigs, Ming Huang, Dezhi Wu, Li-Shiun Chen
{"title":"Motives and Risk Perceptions Among Young Adults Engaged in Frequent Vaping and Dual Cannabis Use: Implications for Prevention and Intervention.","authors":"Patricia A Cavazos-Rehg, Xiao Li, Layna Paraboschi, Erin Kasson, Lucy Meigs, Ming Huang, Dezhi Wu, Li-Shiun Chen","doi":"10.1080/02791072.2026.2727017","DOIUrl":"10.1080/02791072.2026.2727017","url":null,"abstract":"<p><p>Many young adults use vaping products to vape both nicotine and cannabis. Yet, there is a dearth of understanding on their motives for use and risk perceptions of vaping that could have significant clinical implications for designing interventions. In this study, social media was used to recruit 97 young adults aged 15-25 who reported vaping in the past month. Participants completed an online survey assessing vaping behaviors, perceived risks of vaping, and interest in treatment. Descriptive statistics and differences between participants vaping nicotine only and those vaping nicotine and cannabis (dual use) are reported. Vaping was found to be frequent and consistent among all participants, reported on average 25 of the past 30 days. Half of participants reported vaping nicotine only (<i>n</i> = 48, 49.5%) and half reported dual use (<i>n</i> = 49, 50.5%). Participants vaping nicotine only were more likely to perceive vaping as less harmful than smoking (65.9% vs 39.6%; <i>p</i> = .01) and were less likely to report concerns about the negative health consequences of nicotine vaping (Mean (<i>SD</i>): 6.6(2.5) vs 7.7(1.3); <i>p</i> = .01). Two thirds of participants reported interest in quitting, however less than 5% reported receiving treatment. These findings underscore the diverse motives and risk perceptions that shape frequent and dual vaping behaviors and can inform tailored treatment efforts.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Damian Swieczkowski, Aleksander Kwaśny, Wiesław Jerzy Cubała
{"title":"Exploratory Insights into 5-MeO-DMT Experiences on Reddit: A Thematic Analysis.","authors":"Damian Swieczkowski, Aleksander Kwaśny, Wiesław Jerzy Cubała","doi":"10.1080/02791072.2026.2727030","DOIUrl":"https://doi.org/10.1080/02791072.2026.2727030","url":null,"abstract":"<p><p>This qualitative study examines self-reported experiences with 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) shared on Reddit to explore subjective reports, contextual influences, and perceived effects. A total of 120 posts from 24 discussion threads were purposively selected and thematically analyzed using an inductive, constructivist approach. The analysis resulted in 48 codes, which were grouped into seven categories: Administration Methods, Dosage, and Tolerance; Experiential and transformative effects; Pharmacological specificity and interaction; Risk, adverse effects, and harm reduction; Socio-cultural and contextual factors; Support, preparation and integration; and Therapeutic and health-related effects. Users described individualized dosing strategies and a distinct tolerance profile compared to other psychedelics. Narratives emphasized introspective, emotionally cathartic, and spiritually unifying experiences that were often viewed as transformative life events. A preparatory context, supportive environment, and sustained integration practices were seen as essential. Users were aware of pharmacological interactions, particularly with serotonergic medications, and emphasized harm‑minimization measures such as the presence of a trusted sitter. Socio-cultural narratives about the origins, traditions, and ethics of 5-MeO-DMT shaped perceptions and motivation. These findings contribute to the literature on real-world use of psychedelics by highlighting the interplay of pharmacology, personal mind-set, and cultural context, and providing information on harm reduction, preparation, integration, and future research priorities.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.4,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine A Berry, Amie R Newins, Kathryne Van Hedger, Byron L Zamboanga, Michael P Randazza, Alison Looby, Lindsay S Ham, Heidemarie Blumenthal, Jessica Perrotte, Su Yeong Kim, P Priscilla Lui
{"title":"\"Double Trouble?\" Sociodemographic Correlates of Simultaneous Alcohol and Cannabis Use in a Multisite Sample of U.S. College Students.","authors":"Katherine A Berry, Amie R Newins, Kathryne Van Hedger, Byron L Zamboanga, Michael P Randazza, Alison Looby, Lindsay S Ham, Heidemarie Blumenthal, Jessica Perrotte, Su Yeong Kim, P Priscilla Lui","doi":"10.1080/02791072.2026.2727025","DOIUrl":"https://doi.org/10.1080/02791072.2026.2727025","url":null,"abstract":"<p><p>Simultaneous alcohol and cannabis (i.e. marijuana; [SAM]) use is prevalent among college students and is linked to greater negative consequences than using alcohol or cannabis alone or using both substances concurrently. While certain sociodemographic factors are associated with alcohol and cannabis use individually, little is known about which sociodemographic factors are associated with SAM use specifically. The present study examined several sociodemographic variables potentially associated with SAM use in a large, ethnically/racially diverse multi-site sample of college students (<i>n</i> = 3655, 69.7% women, 51% White). Significant differences were not found for most sociodemographic factors between groups differing in endorsement of past-year SAM use. However, students who lived at home with parents or relatives and those living on-campus were both less likely to report engaging in past-year SAM use than those living in off-campus housing. Regarding differences in SAM use frequency, age, gender, race, fraternity/sorority membership, and residency status were significantly associated with frequency of SAM use, whereby older, White, fraternity/sorority members, or students identifying as men were more likely to engage in frequent SAM. Conversely, living with parents or relatives or on campus made it less likely that students would endorse frequent SAM use relative to living off-campus. These findings underscore important sociodemographic factors in understanding, and developing interventions for, problematic SAM use among college students.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebecca Hernandez, Kuang-Heng Jason Hsiao, Essence Bell, Nadia Jubran
{"title":"Case Report: Pharmacist-Led Induction of Sublingual Buprenorphine/Naloxone for Kratom Use Disorder.","authors":"Rebecca Hernandez, Kuang-Heng Jason Hsiao, Essence Bell, Nadia Jubran","doi":"10.1080/02791072.2026.2727015","DOIUrl":"https://doi.org/10.1080/02791072.2026.2727015","url":null,"abstract":"<p><p>Kratom is a psychoactive herbal substance derived from a tree indigenous to Southeast Asia that provides both stimulant and analgesic (opioid agonist) effects. It is currently available in most areas of the United States and has potential for misuse/abuse. The proper treatment of kratom use disorder is not widely defined, but prior case reports and case series purport that sublingual buprenorphine/naloxone is an effective treatment. Pain management clinical pharmacist practitioners (CPPs) are uniquely equipped to work as independent providers and implement the treatment of many disease states including kratom use disorder. We present a case report of a patient who was referred to the CPP-run pain pharmacotherapy clinic for management of chronic lower back pain and shoulder pain in the setting of long-term kratom use. While collaborating with the patient's primary care provider, it was determined that buprenorphine/naloxone would be started to treat his chronic pain and kratom use disorder/dependence. The pain CPP led, planned, and performed the induction of buprenorphine/naloxone and frequently followed up with the patient to reassess his symptoms. The buprenorphine/naloxone, along with other pharmacologic and nonpharmacologic treatments, successfully managed his pain and other symptoms without significant withdrawal or return of cravings.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-5"},"PeriodicalIF":2.4,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jake Hooper, Sarah Williams, Raeghan Mueller, Kent Hutchison
{"title":"Age and Cannabis Co-Use Are Associated with Differences in Experience and Perceived Benefits of Psilocybin: A Retrospective Study.","authors":"Jake Hooper, Sarah Williams, Raeghan Mueller, Kent Hutchison","doi":"10.1080/02791072.2026.2727016","DOIUrl":"https://doi.org/10.1080/02791072.2026.2727016","url":null,"abstract":"<p><p>As psychedelic use increases, understanding how demographic and behavioral factors influence the effects of psychedelics is essential for both research and public health. This cross-sectional retrospective study examined 365 people who currently use psilocybin, analyzing differences in acute experiences, psychological outcomes, and substance co-use patterns. Participants were categorized into young (18-25), middle-aged (26-54), and older (55-77) adults. Results showed that younger participants reported significantly more adverse experiences while older adults had milder effects. Despite differences in adverse experiences, age did not significantly impact mystical experiences, psychological insight, or psychological outcomes. Polysubstance use patterns also varied by age, as younger adults were more likely to co-use nicotine with psilocybin. Cannabis co-use specifically was associated with greater perceived improvements in quality of life, anxiety, depression, and alcohol abuse, suggesting potential synergies between psilocybin and THC. These findings emphasize that age and cannabis co-use may modulate aspects of psilocybin's acute effects and therapeutic outcomes. Given the increasing legalization and accessibility of psychedelics, future research should further investigate mechanisms underlying individual differences and assess the impact of polysubstance use with psychedelics.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fadime Gokce Karaaslan, Cassandra Philippon, Jason A Ford
{"title":"Justice Involvement and Hallucinogen Use Among US Adults: Exploring Health Problems, Other Substance Use, and Demographic Correlates.","authors":"Fadime Gokce Karaaslan, Cassandra Philippon, Jason A Ford","doi":"10.1080/02791072.2026.2727014","DOIUrl":"https://doi.org/10.1080/02791072.2026.2727014","url":null,"abstract":"<p><p>This study explores hallucinogen use, comparing adults with and without a recent history of justice involvement. While past research finds that justice-involved adults are more prone to health problems and substance use behaviors, less attention has been paid to hallucinogen use. Using data from 2021 to 2024 National Survey on Drug Use and Health, we assessed the association between past-year justice involvement and hallucinogen use among U.S. adults. Logistic regression models include demographic characteristics, health-related measures, and other types of substance use. Results indicate that hallucinogen use continues to increase, particularly among adults with recent justice involvement. While both poor health and substance use behaviors were significantly associated with hallucinogen use, once other types of substance use were included in the analysis there was no longer a significant difference in hallucinogen use based on justice involvement. Lastly, we identified several differences in correlates of hallucinogen use among adults with and without justice involvement. Research on hallucinogens is important as some states have moved to decriminalize use and prevalence has increased in recent years. Given the increased risk for poor health and substance use among adults with criminal justice contact, research in this area is important.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danielle J Russell, Ebony Quintrell, Caitlin S Wyrwoll, Erin Kelty
{"title":"Prevalence of the Prescribing of Attention-Deficit Hyperactivity Disorder Medication During Pregnancy: A Systematic Review.","authors":"Danielle J Russell, Ebony Quintrell, Caitlin S Wyrwoll, Erin Kelty","doi":"10.1080/02791072.2025.2478085","DOIUrl":"10.1080/02791072.2025.2478085","url":null,"abstract":"<p><p>Attention deficit hyperactivity disorder (ADHD) diagnosis in women has markedly increased in recent years, resulting in an increase of ADHD medication exposure during pregnancy, which has uncertain health risks. It is therefore critical to understand the extent of the issue. The objective of this novel systematic review was to investigate the prevalence of the prescribing of ADHD medication during pregnancy. A systematic review was conducted following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The last search was October 13, 2023, for articles examining the prescribing of ADHD medication in pregnancy. Fifteen studies were included. Participants from the United States (<i>n</i> = 4), the Nordic countries (<i>n</i> = 10), Canada (<i>n</i> = 3), and Australia (<i>n</i> = 1) were included. The prevalence of ADHD-medication dispensing during pregnancy ranged from 0.07 to 6.01 per 1,000 pregnancies. Typically, stimulant medications were more prevalent than nonstimulants. The most prevalent ADHD medication dispensed during pregnancy was methylphenidate followed by amphetamine-type medications. There was high heterogeneity (I<sup>2</sup> = 99.95%) between the studies, making the study data not appropriate for meta-analysis. The prevalence of the prescribing of ADHD medications in pregnancy ranged substantially, with psychostimulant medications most prescribed. Apart from in the Nordic countries, estimates of prevalence were limited.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"508-518"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Víctor José Villanueva-Blasco, Adelaida Lozano-Polo, Carlos Guillamó Mínguez, Verónica Villanueva-Silvestre, Manuel Isorna Folgar, Vicente Gea-Caballero, Andrea Vázquez-Martínez
{"title":"The Healthcare Profession as a Determinant of Depression, Suicidal Ideation, and Drug Use in Spain During the COVID-19 Pandemic Crisis.","authors":"Víctor José Villanueva-Blasco, Adelaida Lozano-Polo, Carlos Guillamó Mínguez, Verónica Villanueva-Silvestre, Manuel Isorna Folgar, Vicente Gea-Caballero, Andrea Vázquez-Martínez","doi":"10.1080/02791072.2025.2474245","DOIUrl":"10.1080/02791072.2025.2474245","url":null,"abstract":"<p><p>The mental health and substance use of healthcare professionals are vital concerns given their socio-healthcare roles. This study explores whether (a) healthcare profession is associated withthe presence of depression, suicidal ideation, or alcohol, tobacco, and cannabis use, and (b) whether healthcare profession, depression, or suicidal ideation predict substance use. A cross-sectional, observational study was conducted with 630 participants from Psychology, Nursing, Medicine, and Nursing Auxiliary Care Technicians (TCAE). Descriptive analyses and Poisson regression models with robust variance were applied. Results show that TCAE and nurses report higher rates of depression and suicidal ideation, highlighting their vulnerability during health crises. Alcohol is the most consumed substance, with at-risk use prevalent across professions. Tobacco use is highest among psychologists, while cannabis use is low, although 20% of users report problematic use. Severe depression is significantly associated with tobacco use, while its relationships with alcohol and cannabis use are less consistent. Alcohol consumption correlates with sex and healthcare profession, being more common among women, physicians, psychologists, and other healthcare roles. Tobacco use is associated primarily by healthcare profession, while cannabis use is significantly linked to depression, with higher prevalence among professionals without depression. Comprehensive policies addressing these issues are essential.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"479-489"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oliver Grundmann, MeShell Green, Erin Berthold, Saunjoo L Yoon, Diane Ray
{"title":"Prevalence and Use Patterns of Kratom (<i>Mitragyna speciosa</i> Korth.) in a US Nationally Representative Sample.","authors":"Oliver Grundmann, MeShell Green, Erin Berthold, Saunjoo L Yoon, Diane Ray","doi":"10.1080/02791072.2025.2474249","DOIUrl":"10.1080/02791072.2025.2474249","url":null,"abstract":"<p><p>With increasing diversity of kratom (<i>Mitragyna speciosa</i> Korth.) products containing higher amounts of alkaloids including mitragynine and 7-hydroxymitragynine, safety becomes a public concern. The study aimed to estimate the prevalence of kratom use and to examine potential benefits and adverse effects based on kratom product formulations. A cross-sectional survey utilized a non-probabilistic nationally representative sampling with a total of 11,545 respondents of which 1,049 reported current kratom use, indicating a 9.1% prevalence. The most common kratom products used in the past 30 days were pills, gummies and powder formulations. Pain relief (<i>n</i> = 603, 57.5%) was the most common condition for using kratom, followed by relaxation/stress relief (<i>n</i> = 562, 53.6%) and boost energy (<i>n</i> = 520, 49.6%). The reported benefits were increased energy from tea bags and improved sleep with leaf or extract powders. A significant positive correlation was found between the increased frequency of consuming kratom shots/extract powder and pain relief (<i>p</i> = .009 and 0.015, respectively. A higher incidence of adverse effects was reported as the amount of kratom per dose increased with gummies/capsules/tablets/pills. The lack of standardization and consistency in kratom products results in unpredictable effects, emphasizing the need for increased research to establish reliable safety guidelines for dosage recommendations.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"432-440"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanqiu Yu, Nick Tse, Tsun Kwan Mary Ip, Phoenix K H Mo, Joseph T F Lau
{"title":"Factors of Psychoactive Substance Use Behaviors and Intention Among Social Workers' Adolescent Case-Work Clients in Hong Kong.","authors":"Yanqiu Yu, Nick Tse, Tsun Kwan Mary Ip, Phoenix K H Mo, Joseph T F Lau","doi":"10.1080/02791072.2025.2483701","DOIUrl":"10.1080/02791072.2025.2483701","url":null,"abstract":"<p><p>Based on Social Cognitive Theory (SCT), this study investigated the factors of psychoactive substance use in terms of current use (past 30 days), lifetime use, and behavioral intention (next 12 months) in Hong Kong adolescent case-clients of social workers from July 2021 to June 2022. The prevalence of current/lifetime psychoactive substance use and behavioral intention to use psychoactive substances was 7.6%/20.9% and 8.6%, respectively. The SCT constructs of positive outcome expectancy of psychoactive substance use, the observational learning indicators, and the environmental factor (easiness to obtain psychoactive substances) were positively associated with current and lifetime psychoactive substance use. Similar associations involving negative outcome expectancy (NOE), emotional relief refusal self-efficacy (RSE), and opportunistic RSE were significant and negative. Furthermore, NOE, emotional relief RSE, and social facilitation RSE were significantly associated with behavioral intention of psychoactive substance use. Future longitudinal studies are warranted to confirm the findings and test pilot interventions.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"561-570"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}