Journal of psychoactive drugs最新文献_第2页

Translation and Initial Psychometric Evaluation of Spanish Versions of Three Psychedelic Acute Effects Measures: Mystical, Challenging, and Insight Experiences. 三种迷幻剂急性效应测量的西班牙语版本的翻译和初步心理测量评估：神秘体验、挑战体验和洞察体验。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-07-14 DOI: 10.1080/02791072.2023.2232379

Alan K Davis, Christopher Timmermann, Ana Maria Ortiz Bernal, Rafaelle Lancelotta, Sandeep Nayak, Nathan D Sepeda, Aki Nikolaidis, Roland R Griffiths

{"title":"Translation and Initial Psychometric Evaluation of Spanish Versions of Three Psychedelic Acute Effects Measures: Mystical, Challenging, and Insight Experiences.","authors":"Alan K Davis, Christopher Timmermann, Ana Maria Ortiz Bernal, Rafaelle Lancelotta, Sandeep Nayak, Nathan D Sepeda, Aki Nikolaidis, Roland R Griffiths","doi":"10.1080/02791072.2023.2232379","DOIUrl":"10.1080/02791072.2023.2232379","url":null,"abstract":"This study translated and tested the psychometric properties of acute psychedelic effects measures among Spanish-speaking people. The Psychological Insight Questionnaire (PIQ), Challenging Experiences Questionnaire (CEQ), and Mystical Experiences Questionnaire (MEQ) were translated before being incorporated into a web-based survey. We recruited native Spanish-speakers (N = 442; Mage = 30.8, SD = 10.9; Latino/Latina = 62%; Hispanic = 91.4%; male = 71.5%) to assess their previous experience with one of two psychedelics (LSD = 58.4%; Psilocybin = 41.6%) and their acute and enduring effects. Confirmatory factor analysis (confirming factor structure based on the English version) revealed a good fit for the MEQ, PIQ and the CEQ. Repeating our analysis in each drug subsample revealed consistency in factor structure for each assessment tool. Construct validity was supported by significant positive associations between the PIQ and MEQ, and between the PIQ and MEQ and changes in cognitive fusion and negative associations between changes in prosocial behaviors. As a signal of predictive validity, persisting effects (PEQ) were strongly related to scores on the MEQ and PIQ. Findings demonstrate that the Spanish versions of these measures can be reliably employed in studies of psychedelic use or administration in Spanish-speaking populations.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the mushrooming reports of "quiet quitting": Employees' lifetime psilocybin use predicts their overtime hours worked. 关于 "默默辞职 "的报道如雨后春笋般涌现：员工终生服用迷幻药的情况可预测其加班时间。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-07-31 DOI: 10.1080/02791072.2023.2242358

Benjamin A Korman

{"title":"On the mushrooming reports of \"quiet quitting\": Employees' lifetime psilocybin use predicts their overtime hours worked.","authors":"Benjamin A Korman","doi":"10.1080/02791072.2023.2242358","DOIUrl":"10.1080/02791072.2023.2242358","url":null,"abstract":"Despite the recent and sharp rise in psychedelic research, few studies have investigated how classic psychedelic use relates to employees' work-related outcomes. This is surprising given that the increased use, decriminalization, and legalization of classic psychedelics in the United States (U.S.) has the potential to impact both employees and their organizations. Addressing this gap, the current study explores how employees' lifetime psilocybin use relates to the amount of overtime they work, thereby offering insight into what current trends in psilocybin use could mean for businesses. Using pooled, cross-sectional data from the National Survey on Drug Use and Health (2002-2014) on 217,963 adults employed in the U.S. full-time, this study tests whether lifetime psilocybin use is associated with employees' number of overtime hours worked in the past week. After adjusting for sociodemographics and other substance use, a significant negative association is found between employees' lifetime psilocybin use and the amount of overtime they reported working. Specifically, the findings suggest that lifetime psilocybin use in the U.S. full-time working population is associated with an estimated 44,348,400 fewer overtime hours worked per year and may help explain recent findings linking employees' lifetime psilocybin use to a reduction in sick leave taken.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9965527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N, N-Dimethyltryptamine (DMT)-Occasioned Familiarity and the Sense of Familiarity Questionnaire (SOF-Q). N，N-二甲基色胺（DMT）引起的熟悉感和熟悉感问卷（SOF-Q）。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-07-10 DOI: 10.1080/02791072.2023.2230568

David Wyndham Lawrence, Alex P DiBattista, Christopher Timmermann

{"title":"N, N-Dimethyltryptamine (DMT)-Occasioned Familiarity and the Sense of Familiarity Questionnaire (SOF-Q).","authors":"David Wyndham Lawrence, Alex P DiBattista, Christopher Timmermann","doi":"10.1080/02791072.2023.2230568","DOIUrl":"10.1080/02791072.2023.2230568","url":null,"abstract":"This study investigated the sense of familiarity attributed to N, N-dimethyltryptamine (DMT) experiences. 227 naturalistic inhaled-DMT experiences reporting a sense of familiarity were included. No experiences referenced a previous DMT or psychedelic experience as the source of the familiarity. A high prevalence of concomitant features discordant from ordinary consciousness were identified: features of a mystical experience (97.4%), ego-dissolution (16.3%), and a \"profound experience of death\" (11.0%). The Sense of Familiarity Questionnaire (SOF-Q) was developed assessing 19 features of familiarity across 5 themes: (1) Familiarity with the Feeling, Emotion, or Knowledge Gained; (2) Familiarity with the Place, Space, State, or Environment; (3) Familiarity with the Act of Going Through the Experience; (4) Familiarity with Transcendent Features; and (5) Familiarity Imparted by an Entity Encounter. Bayesian latent class modeling yielded two stable classes of participants who shared similar SOF-Q responses. Class 1 participants responded, \"yes\" more often for items within \"Familiarity Imparted by an Entity Encounter\" and \"Familiarity with the Feeling, Emotion, or Knowledge Gained.\" Results catalogued features of the sense of familiarity imparted by DMT, which appears to be non-referential to a previous psychedelic experience. Findings provide insights into the unique and enigmatic familiarity reported during DMT experiences and offer a foundation for further exploration into this intriguing phenomenon.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9757490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey of U.S. Residents and Their Usage of Electronic Cigarettes with Drugs Other Than Nicotine. 美国居民及其尼古丁以外药物电子烟使用情况调查。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-08-26 DOI: 10.1080/02791072.2023.2250353

Alaina K Holt, Alyssa K Rudy, Ashlee N Sawyer, Justin L Poklis, Alison B Breland, Michelle R Peace

{"title":"Survey of U.S. Residents and Their Usage of Electronic Cigarettes with Drugs Other Than Nicotine.","authors":"Alaina K Holt, Alyssa K Rudy, Ashlee N Sawyer, Justin L Poklis, Alison B Breland, Michelle R Peace","doi":"10.1080/02791072.2023.2250353","DOIUrl":"10.1080/02791072.2023.2250353","url":null,"abstract":"Electronic cigarettes (e-cigs), originally intended to be used as cigarette substitutes, have evolved into discreet devices for consuming drugs other than nicotine (DOTNs). Presented are the results of an exploratory survey in which information regarding demographics, e-cig device type, DOTN use, frequency and context of use was collected. The average reported age of respondents was 27.4 years of age (SD = 12.0), and respondents predominantly identified as male (73%). Vape pens (disposable or refillable) were the most reported device across all DOTN classes. Cannabinoids were the most reported class of DOTN used, for both lifetime and past 30-day use. Other DOTNs reported included herbal supplements, amphetamines, caffeine, kratom, vitamins, opiates, DMT, fentanyl, and ketamine. Combinations of DOTNs used in e-cigs and trends in poly-substance use were reported. The most commonly reported context was vaping alone, followed by with friends, at home, and at social events; less commonly reported contexts included when driving, at work, and at school. Results from this study are useful for developing future national surveys to consider a comprehensive substance use-focused strategy that includes vaping, building awareness of DOTN e-cig use, and highlighting public safety issues in driving impairment, crime scene investigations, and death investigations.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10075427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of Alprazolam Use in Pregnancy in Western Australia: A Retrospective Cohort Study Using Linked Health Data. 西澳大利亚妊娠期使用阿普唑仑的安全性：一项使用关联健康数据的回顾性队列研究。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-07-28 DOI: 10.1080/02791072.2023.2241465

Erin Kelty, Kate Chitty, David B Preen

{"title":"Safety of Alprazolam Use in Pregnancy in Western Australia: A Retrospective Cohort Study Using Linked Health Data.","authors":"Erin Kelty, Kate Chitty, David B Preen","doi":"10.1080/02791072.2023.2241465","DOIUrl":"10.1080/02791072.2023.2241465","url":null,"abstract":"The use of alprazolam in pregnancy can adversely affect maternal and neonatal health. This study examined neonatal outcomes following exposure to alprazolam in pregnancy. Women prescribed alprazolam during pregnancy (n = 48) between 2014 and 2018 were identified from routinely-collected state administrative prescribing records and perinatal data. Two comparison groups of women; 1) prescribed alprazolam outside of pregnancy (n = 96) and 2) women never prescribed alprazolam (n = 96) were also identified. The health of women and their children was examined using administrative hospital, mortality and perinatal data and compared to the comparison groups using generalized linear models. Prenatal alprazolam exposure was not associated with a reduction in average birth weight or gestational age. However, neonates prenatally exposed to alprazolam were more likely be classified as having low birth weight for gestational age compared with alprazolam comparison group (OR: 4.46, 95% CI: 1.54-12.95) and the non-alprazolam comparison group (OR: 3.27, 95% CI: 1.22-8.79). There were no cases of perinatal mortality or floppy baby syndrome in alprazolam-exposed neonates. While the use of alprazolam during pregnancy was not associated with an increased risk of severe adverse neonatal outcomes (e.g. perinatal mortality), it was associated with neonates being born with a low birth weight for gestational age.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9884600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal Variation of Use of Common Psychedelics and Party Drugs Among Nightclub/Festival Attendees in New York City. 纽约市夜总会/节日参与者使用常见迷幻药和派对药物的季节性变化。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-08-21 DOI: 10.1080/02791072.2023.2240322

Joseph J Palamar, Caroline Rutherford, Austin Le, Katherine M Keyes

{"title":"Seasonal Variation of Use of Common Psychedelics and Party Drugs Among Nightclub/Festival Attendees in New York City.","authors":"Joseph J Palamar, Caroline Rutherford, Austin Le, Katherine M Keyes","doi":"10.1080/02791072.2023.2240322","DOIUrl":"10.1080/02791072.2023.2240322","url":null,"abstract":"Few epidemiological studies have focused on seasonal variation in the use of common psychedelics and party drugs among nightclub and festival attendees, typically those who attend electronic dance music (EDM) events. We sought to determine whether the use of different drug types varies seasonally within this population. Across 15 seasons from summer 2017 through fall 2022, we surveyed 3,935 adults entering randomly selected nightclubs and festivals in New York City regarding their past-month use of cocaine, MDMA (3,4-methylenedioxymethamphetamine, commonly known as ecstasy), lysergic acid diethylamide (LSD), psilocybin (shrooms), and ketamine. Multivariable models were used to compare adjusted odds ratios for drug use within each season with the grand mean of combined seasons. Summer was associated with higher odds for use of LSD (aOR 2.72; 95% CI, 1.88-3.93) and psilocybin (aOR 1.65; CI, 1.12-2.43), independent of increases in psilocybin use over time (p < .001). A significant increase in use of ketamine (p = .014) and significant decreases in use of cocaine (p = .002) and ecstasy (p = .002) were found across time, but multivariable models did not detect seasonal variations. Summer is a risk factor for use of common psychedelics among people who attend EDM events. Therefore, the summer months may be the best time to disseminate information about harm reduction for psychedelic drug users.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10879452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10100866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Protocols Using Ketamine and Esketamine for Depressive Disorders: A Systematic Review. 使用氯胺酮和 Esketamine 治疗抑郁症的方案：系统性综述。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-08-28 DOI: 10.1080/02791072.2023.2248989

Julia M K Freind, Fernando R Beserra, Bruno S Menezes, Daniel C Mograbi

{"title":"Therapeutic Protocols Using Ketamine and Esketamine for Depressive Disorders: A Systematic Review.","authors":"Julia M K Freind, Fernando R Beserra, Bruno S Menezes, Daniel C Mograbi","doi":"10.1080/02791072.2023.2248989","DOIUrl":"10.1080/02791072.2023.2248989","url":null,"abstract":"Depression is one of the most prevalent mental health disorders globally, causing severe emotional suffering, reducing life expectancy and increasing the risk of suicide. Recently, the use of dissociative psychedelic substances such as ketamine and esketamine for depressive disorders has expanded treatment options. We sought to analyze, through a systematic review, the existing protocols for the treatment of depression with ketamine and esketamine. The search adopted PRISMA criteria and was performed using PubMed and Web of Science databases. Procedures in each study were compared, focusing on the sample recruited, therapeutic approaches, including the clinical team and professionals engaged in treatment, medical procedures, description of the setting (including music) and factors such as specific medication (ketamine or esketamine), route of administration and dosage employed. Results indicated the predominance of a medical approach, with a limited number of studies on ketamine assisted psychotherapy (KAP) and other modalities of psychedelic assisted therapy. Additionally, there is limited information on psychosocial elements such as preparation, psychological support during session and integration of experience. Altogether these findings suggest that treatment of depression with ketamine or esketamine diverges in relation to the practices employed with psychedelic substances. This is discussed considering future research directions in the field.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10075506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploratory Growth Mixture Modeling of Cannabis-Withdrawal Syndrome Trajectories of Adult Pure Cannabis Dependents During Detoxification: Two Subtypes? 成年纯大麻依赖者戒毒期间大麻-戒断综合征轨迹的探索性增长混合模型：两种亚型？

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-07-18 DOI: 10.1080/02791072.2023.2229830

Benedikt Bernd Claus, Norbert Scherbaum, Michael Specka, Patrik Roser, Udo Bonnet

{"title":"Exploratory Growth Mixture Modeling of Cannabis-Withdrawal Syndrome Trajectories of Adult Pure Cannabis Dependents During Detoxification: Two Subtypes?","authors":"Benedikt Bernd Claus, Norbert Scherbaum, Michael Specka, Patrik Roser, Udo Bonnet","doi":"10.1080/02791072.2023.2229830","DOIUrl":"10.1080/02791072.2023.2229830","url":null,"abstract":"As clinical studies about subtypes of the cannabis withdrawal syndrome (CWS) are scant, we performed a re-analysis of longitudinal data with German adult cannabis-users seeking inpatient cannabis detoxification-treatment. Sixty-seven cannabis-dependents without active comorbidity were included for growth-mixture-analysis (GMM) of their CWS-severity-trajectories during a scheduled 24-day detox-treatment. As of treatment-day 12, thirty-six (53.7%) of 67 patients were discharged after successful detoxification. This led to artificial imputations for I-GMM. Therefore, we preferred the results of the GMM including raw data-only (R-GMM). By both, I-GMM and R-GMM, we found two classes of CWS severity time-courses. Class one (n = 44, R-GMM) showed a continuously decreasing CWS-severity; class two (n = 23, R-GMM) exhibited a sharp peak (generally between days 2-6 post-cessation). A short inpatient treatment-period and low urinary 11-nor-9-carboxy-Δ9 -tetrahydrocannabinol-level upon admission predicted the peaking trajectory of R-GMM-class-two-CWS. Withdrawal syndrome medication (PRN), comorbidity, cannabis-history data and gender balance were not significantly different between the CWS-classes. Although possibly confounded by PRN-medication, this exploratory study supports the presence of two CWS-variants in adult cannabis-dependents, characterized by a slowly decreasing (\"protracted\") slope (class one) or a clear crescendo-decrescendo trajectory (class two). The latter was associated with a significantly shorter inpatient detoxification period and lower urinary THC-COOH-levels at admission.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THC-O-Acetate: Scarce Evidence for a Psychedelic Cannabinoid. 乙酸 THC-O：迷幻大麻素的稀缺证据。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-06-29 DOI: 10.1080/02791072.2023.2230573

Daniel J Kruger, Carlton Cb Bone, Meredith C Meacham, Charles Klein, Jessica S Kruger

{"title":"THC-O-Acetate: Scarce Evidence for a Psychedelic Cannabinoid.","authors":"Daniel J Kruger, Carlton Cb Bone, Meredith C Meacham, Charles Klein, Jessica S Kruger","doi":"10.1080/02791072.2023.2230573","DOIUrl":"10.1080/02791072.2023.2230573","url":null,"abstract":"There is a growing interest in semi-synthetic cannabinoids, including THC-O-acetate (THC-Oac). Some cannabis marketers and users have claimed that THC-Oac produces psychedelic effects; the current study is the first to examine this claim. Researchers developed an online survey for THC-Oac consumers based on previous cannabis and psychedelic use surveys and in consultation with the moderator of an online forum. The survey assessed the experiential profile of THC-Oac and included items from the Mystical Experience Questionnaire (MEQ), an instrument for assessing psychedelic experiences. Participants reported a low to moderate level of cognitive distortions (altered sense of time, difficulties concentrating, difficulties with short-term memory) and few visuals or hallucinations. Participants' responses were significantly below the threshold for a complete mystical experience on all four MEQ dimensions. Participants who had used classic (5-HT2A agonist) psychedelics had lower scores on all MEQ dimensions. When asked directly, 79% responded that using THC-Oac is \"not at all\" or \"a little\" of a psychedelic experience. Some reports of psychedelic experiences may be due to expectations or contaminants. Those having prior experience with classic psychedelics had lower ratings of mystical experiences.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9699062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Psilocybin: Reviewing the Therapeutic Potential of Other Serotonergic Psychedelics in Mental and Substance Use Disorders. 超越迷幻剂：回顾其他血清素能迷幻剂对精神障碍和药物使用障碍的治疗潜力。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-08-24 DOI: 10.1080/02791072.2023.2251133

Stanley Wong, An Yi Yu, Nicholas Fabiano, Ofer Finkelstein, Aryan Pasricha, Brett D M Jones, Joshua D Rosenblat, Daniel M Blumberger, Benoit H Mulsant, M Ishrat Husain

{"title":"Beyond Psilocybin: Reviewing the Therapeutic Potential of Other Serotonergic Psychedelics in Mental and Substance Use Disorders.","authors":"Stanley Wong, An Yi Yu, Nicholas Fabiano, Ofer Finkelstein, Aryan Pasricha, Brett D M Jones, Joshua D Rosenblat, Daniel M Blumberger, Benoit H Mulsant, M Ishrat Husain","doi":"10.1080/02791072.2023.2251133","DOIUrl":"10.1080/02791072.2023.2251133","url":null,"abstract":"There has been a resurgence of interest in the use of psychedelic therapies for several mental and substance use disorders. Psilocybin, a \"classic\" serotonergic psychedelic, has emerged as one of the primary compounds of interest in clinical research. While research on psilocybin's potential mental health benefits has grown, data on the safety and efficacy of other serotonergic psychedelics remain limited. A comprehensive scoping review on the use of mescaline, ibogaine, ayahuasca, N,N-dimethyltryptamine (DMT), and lysergic acid diethylamide (LSD) in the treatment of mental and substance disorders was conducted. Independent reviewers screened titles, abstracts, and full texts and conducted data extraction. Seventy-seven studies met the inclusion criteria. There were 43 studies of LSD, 24 studies of ayahuasca, 5 studies of DMT, 5 studies of ibogaine, and 5 studies of mescaline. Commonly reported benefits included improved mood and anxiety symptoms, improved insight, reduced substance use, improved relationships, and decreased vegetative symptoms. Commonly reported adverse effects were psychological, neurological, physical, and gastrointestinal in nature. Serious adverse events (homicide and suicide) were reported in published studies of LSD. In conclusion, there is only low-level evidence to support the safety and efficacy of non-psilocybin serotonergic psychedelics in individuals with mental and substance use disorders.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10050444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0