Journal of psychoactive drugs最新文献_第3页

Correction. 修正。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-27 DOI: 10.1080/02791072.2025.2498792

引用次数: 0

Exploring Factors Affecting Psychological Flexibility After Psychedelic Experiences. 探索影响迷幻体验后心理灵活性的因素。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-25 DOI: 10.1080/02791072.2025.2495937

B Romeo, E Kervadec, B Fauvel, L Strika-Bruneau, A Amirouche, V Verroust, P Piolino, A Benyamina

{"title":"Exploring Factors Affecting Psychological Flexibility After Psychedelic Experiences.","authors":"B Romeo, E Kervadec, B Fauvel, L Strika-Bruneau, A Amirouche, V Verroust, P Piolino, A Benyamina","doi":"10.1080/02791072.2025.2495937","DOIUrl":"https://doi.org/10.1080/02791072.2025.2495937","url":null,"abstract":"Neurobiological effects and psychological models propose that psychedelics may promote psychological flexibility, suggesting a transdiagnostic effect by disrupting maladaptive patterns. The objective of this study was therefore to investigate the determinants of psychological flexibility change following a psychedelic use. This retrospective online survey included French individuals who had undergone a significant psychedelic experience. Participants were assessed for mystical experience intensity with the MEQ-30, and psychological flexibility via the AAQ-II, at three retrospective time points. Data analysis comprised descriptive statistics, correlation analysis, ANCOVA to evaluate the impact of psychedelic use variables on psychological flexibility, and linear regression to identify predictors of psychological flexibility changes. Data showed a positive correlation between mystical experience intensity and improvements in psychological flexibility, especially 1-month post-experience (p < .01), and during the 6 months before the survey (p < .01). Key predictors of changes in psychological flexibility included baseline AAQ-II scores, MEQ total scores and frequent psychedelic use, underlining the interaction between personal and experiential factors in determining therapeutic outcomes. In conclusion, this study highlights how the intensity of mystical experience and baseline psychological flexibility may be the key factors influencing changes in psychological flexibility post-psychedelic use, suggesting a potential therapeutic value.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-12"},"PeriodicalIF":2.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial Differences in Naturalistic Psychedelic Use - Motivations for Use, Communication with Health Care Providers, and Outcomes. 自然致幻剂使用的种族差异——使用动机、与卫生保健提供者的沟通和结果。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-22 DOI: 10.1080/02791072.2025.2491381

Nicolas G Glynos, Mallet R Reid, Jacob S Aday, Daniel J Kruger, Kevin F Boehnke, Stephanie Lake, Philippe Lucas

{"title":"Racial Differences in Naturalistic Psychedelic Use - Motivations for Use, Communication with Health Care Providers, and Outcomes.","authors":"Nicolas G Glynos, Mallet R Reid, Jacob S Aday, Daniel J Kruger, Kevin F Boehnke, Stephanie Lake, Philippe Lucas","doi":"10.1080/02791072.2025.2491381","DOIUrl":"https://doi.org/10.1080/02791072.2025.2491381","url":null,"abstract":"People of Color have been under-included in psychedelic-assisted therapy (PAT) research. Researchers have argued that systemic issues resulting in harms to communities of color like the War on Drugs and recurrent exposure to discrimination in healthcare settings may reduce their willingness to engage in PAT research. However, there are no empirical data regarding People of Color's trust or willingness in using psychedelics with support of trained healthcare providers. Therefore, we analyzed data from a large-scale survey of people using psychedelics to explore interactions between People of Color and healthcare providers in North America. The sample included 3,547 White people, 448 People of Color, and 377 Multiracial people. A lower proportion of People of Color consumed psychedelics with the support of a trained provider but an equal proportion had disclosed psychedelic use to primary care providers. Further, People of Color were equally motivated to use psychedelics with a trained healthcare provider, used psychedelics to treat similar issues, and similarly reported psychedelics as effective with other groups. Our findings suggest that lack of trust may not fully explain the underrepresentation of People of Color in PAT research, and future studies should investigate other barriers to People of Color's inclusion in PAT research.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-12"},"PeriodicalIF":2.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not Losing Momentum: Cross-Sectional Insights into Ibogaine Clinical Trials. 不失势头：伊博加因临床试验的横断面洞察。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-18 DOI: 10.1080/02791072.2025.2491385

Damian Swieczkowski, Aleksander Kwaśny, Krzysztof Sadko, Wiesław Jerzy Cubała

{"title":"Not Losing Momentum: Cross-Sectional Insights into Ibogaine Clinical Trials.","authors":"Damian Swieczkowski, Aleksander Kwaśny, Krzysztof Sadko, Wiesław Jerzy Cubała","doi":"10.1080/02791072.2025.2491385","DOIUrl":"https://doi.org/10.1080/02791072.2025.2491385","url":null,"abstract":"Ibogaine, a non-classical psychedelic, has gained increasing attention as a potential treatment for substance use disorders (SUD); however, a lack of commercial interest and safety-related concerns limit its clinical development. This cross-sectional study investigates the current landscape of clinical trials involving ibogaine, a non-classical psychedelic, focusing on its safety and efficacy. We extracted data from ClinicalTrials.Gov, EU Clinical Trials (https://euclinicaltrials.eu/), the EU Clinical Trials Register (https://www.clinicaltrialsregister.eu/), and the International Clinical Trials Registry Platform (World Health Organization). After rigorous screening and deduplication, we analyzed nine trials. Our findings revealed considerable variability in methodologies, including fixed-dose and ascending-dose designs, diverse inclusion and exclusion criteria, and differing primary and secondary outcomes. Early-phase trials dominate, primarily focusing on pharmacokinetics, withdrawal symptom reduction, and safety monitoring. Key findings indicate significant differences in how safety concerns are addressed, particularly regarding ibogaine's cardiovascular risk. While preliminary evidence suggests potential therapeutic benefits, the absence of large-scale, late-phase trials limits definitive conclusions. Our study underscores the need for a standardized clinical framework to ensure reliable assessments of ibogaine's efficacy and safety. Lessons from research on classical psychedelics, and MDMA could help improve trial design and reduce issues related to blinding and expectancy bias.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ayahuasca Retreats: The Role of Awe and Mystical Experiences in Well-Being. 死藤水静修：敬畏和神秘体验在幸福中的作用。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-16 DOI: 10.1080/02791072.2025.2491378

Brant Maclean, Amy Wilson, Andrew Allen, Vikki Schaffer, Lee Kannis-Dymand

{"title":"Ayahuasca Retreats: The Role of Awe and Mystical Experiences in Well-Being.","authors":"Brant Maclean, Amy Wilson, Andrew Allen, Vikki Schaffer, Lee Kannis-Dymand","doi":"10.1080/02791072.2025.2491378","DOIUrl":"https://doi.org/10.1080/02791072.2025.2491378","url":null,"abstract":"Research on the positive psychological effects of psychedelics has surged since the early 2000s, particularly regarding increased well-being. Studies have demonstrated how psychedelic-occasioned mystical experiences play a key role in their positive effects, which has prompted an interest in the emotion of awe in the psychedelic context due to its similar phenomenology and associated benefits. This study examined 60 individuals following their visitation to at least one ayahuasca retreat in a country where ayahuasca use was legal or retreats are approved to use ayahuasca, hypothesizing that not only high levels of awe but mystical experiences characterized by high levels of awe would be significantly associated with higher well-being. Neither hypothesis was supported: higher levels of mystical experience with lower perceived vastness, a facet of awe, was significantly associated with higher well-being, possibly highlighting the synergistic relationship between mystical experiences and perceived vastness on well-being. The study has implications for future research, particularly in terms of understanding how the perceived vastness of a person's psychedelic experience may be modulated to mitigate distress and foster well-being.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Qualitative Inquiry into the Challenges in Overcoming Heroin Addiction Among Chinese Individuals Who Experience Voluntary Rehabilitation. 对自愿戒毒的中国人在克服海洛因毒瘾过程中所面临挑战的定性调查。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-01 Epub Date: 2024-02-13 DOI: 10.1080/02791072.2024.2315316

Liu Liu, Zhenni Tang, Xuemeng Li, Wing Hong Chui

引用次数: 0

Sweating for Sobriety: Exploring the Relationship Between Exercise Engagement and Substance Use Disorders. 为清醒而流汗：探索参与运动与药物使用障碍之间的关系。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-01 Epub Date: 2024-02-01 DOI: 10.1080/02791072.2024.2311143

Baldur Jón Gústafsson, Cheneal Puljević, Emma L Davies, Monica J Barratt, Jason Ferris, Adam Winstock, Timothy Piatkowski

{"title":"Sweating for Sobriety: Exploring the Relationship Between Exercise Engagement and Substance Use Disorders.","authors":"Baldur Jón Gústafsson, Cheneal Puljević, Emma L Davies, Monica J Barratt, Jason Ferris, Adam Winstock, Timothy Piatkowski","doi":"10.1080/02791072.2024.2311143","DOIUrl":"10.1080/02791072.2024.2311143","url":null,"abstract":"Despite various interventions available for substance use disorders, relapse rates remain substantial and, therefore, alternative strategies for attenuating dependence are needed. This study examined the associations between exercise frequency, illicit substance use, and dependence severity among a large sample of people who use drugs. The study utilized data from the Global Drug Survey 2018 (N = 57,110) to investigate the relationship between exercise frequency, illicit substance use, and substance dependence severity. Binomial regressions were employed to examine the relationship between exercise and SDS scores for 9 drugs. Greater exercise frequency correlated with reduced severity of substance dependence for specific drugs: cannabis (χ2 = 14.75, p < .001), MDMA (χ2 = 4.73, p = .029), cocaine (χ2 = 8.37, p = .015), amphetamine powder (χ2 = 6.39, p = .041), and methamphetamine (χ2 = 15.17, p < .001). These findings suggest a potential link between exercise and reduced substance use dependency. Further research is needed to understand the complex dynamics between exercise and substance use, considering potential bidirectional relationships and concurrent factors.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"223-233"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometric Properties of the Credibility/Expectancy Questionnaire in Individuals with Opioid Use Disorder. 阿片类药物使用障碍患者可信度/期望值问卷的心理测量特性

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-01 Epub Date: 2024-10-23 DOI: 10.1080/02791072.2024.2420342

Kübra Sezer Katar, Gamze Zengin İspir, Mustafa Danışman

{"title":"Psychometric Properties of the Credibility/Expectancy Questionnaire in Individuals with Opioid Use Disorder.","authors":"Kübra Sezer Katar, Gamze Zengin İspir, Mustafa Danışman","doi":"10.1080/02791072.2024.2420342","DOIUrl":"10.1080/02791072.2024.2420342","url":null,"abstract":"Credibility and expectancy are important aspects of therapy/treatment processes. We aimed to perform cross-cultural validation and examine the psychometric properties of the Credibility/Expectancy Questionnaire (CEQ). Ninety-one patients with opioid use disorder from Tobacco, Alcohol, and Drug Addiction Treatment Program were included in the study. Sociodemographic data form, CEQ, Beck Depression Inventory (BDI), State and Trait Anxiety Inventory (STAI), and Attitudes Toward Seeking Psychological Professional Help Scale-Short Form (ATSPPHS-SF) were filled out by participants. Confirmatory factor analyses showed that CEQ has two factors in our sample, similar to the original version. Reliability analyses showed that CEQ has a high internal consistency and test-retest reliability. Regarding convergent validity results, CEQ was correlated with ATSPPHS-SF. No significant correlation was found between CEQ and BDI and STAI regarding discriminant validity results. In conclusion, the Turkish version of CEQ is a valid, reliable scale and could be used in patients with opioid use disorder. In patients with opioid use disorder, we contributed to the addiction literature by adapting a short and effective survey that measures trust and expectation.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"129-136"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct-To-Definitive Urine and Oral Fluid Test Results for Unscreened and Rarely Screened Drugs in Individuals Applying for Methadone Treatment in 7 U.S. States. 美国 7 个州申请美沙酮治疗者尿液和口腔液中未筛查和罕见筛查药物的直接定量检测结果。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-01 Epub Date: 2024-02-08 DOI: 10.1080/02791072.2024.2314220

Miranda J Lee-Easton, Stephen Magura, Ruqayyah Abu-Obaid, Pete Reed, Brandi Allgaier, Emily Fish, Abigail Maletta, Piyadarsha Amaratunga, Bridget Lorenz-Lemberg, Matthew Levitas, EricD Achtyes

{"title":"Direct-To-Definitive Urine and Oral Fluid Test Results for Unscreened and Rarely Screened Drugs in Individuals Applying for Methadone Treatment in 7 U.S. States.","authors":"Miranda J Lee-Easton, Stephen Magura, Ruqayyah Abu-Obaid, Pete Reed, Brandi Allgaier, Emily Fish, Abigail Maletta, Piyadarsha Amaratunga, Bridget Lorenz-Lemberg, Matthew Levitas, EricD Achtyes","doi":"10.1080/02791072.2024.2314220","DOIUrl":"10.1080/02791072.2024.2314220","url":null,"abstract":"The standard protocol in addiction treatment/pain management is to conduct immunoassay screens for major drugs subject to misuse, followed by confirmatory testing of positive results. However, this may miss unscreened or rarely screened drugs that could pose risks, especially to polydrug users. We sought to determine the prevalences of unscreened/rarely screened drugs in a sample of individuals misusing drugs in 7 U.S. states, and to compare the results of urine vs. oral testing for these drugs by direct-to-definitive liquid chromatography/tandem mass spectrometry (LC-MS-MS). The five drugs with the highest prevalences were: gabapentin (16.8%), quetiapine (6.2%), chlorpheniramine (5.3%), hydroxyzine (4.9%), and ephedrine (3.5%). All have clinical significance as indicated by severity of possible side effects, interactions with other drugs, and/or misuse potential. Drugs were generally detected more frequently in oral fluid than urine, but gabapentin was more frequently detected in urine. The prevalences of the included drugs seem high enough, and their clinical significance important enough, to warrant consideration of expanding clinical drug test panels, either by direct-to-definitive testing or the addition of selected immunoassay screens when available. Oral fluid was usually more suitable than urine as the test matrix, given the higher rates of detection in oral fluid for most substances included in this study.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"137-148"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Ayahuasca on Gratitude and Relationships with Nature: A Prospective, Naturalistic Study. 死藤水对感恩以及与自然关系的影响：前瞻性自然研究

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-01 Epub Date: 2024-02-04 DOI: 10.1080/02791072.2024.2312980

Jacob S Aday, Emily K Bloesch, Alan K Davis, Sarah E Domoff, Kyle Scherr, Josh D Woolley, Christopher C Davoli

{"title":"Effects of Ayahuasca on Gratitude and Relationships with Nature: A Prospective, Naturalistic Study.","authors":"Jacob S Aday, Emily K Bloesch, Alan K Davis, Sarah E Domoff, Kyle Scherr, Josh D Woolley, Christopher C Davoli","doi":"10.1080/02791072.2024.2312980","DOIUrl":"10.1080/02791072.2024.2312980","url":null,"abstract":"Qualitative studies and anecdotal reports suggest that experiences with ayahuasca, a psychedelic brew found in Central and South America, may be followed by individuals enduringly feeling more grateful and connected to nature. Yet, to date, these changes have been understudied. Here, participants (N = 54) completed validated surveys related to gratitude, nature relatedness, and nature appreciation one-week before, one-week after, and one-month after attending an ayahuasca retreat center. Compared to baseline, there was a significant increase in gratitude, nature relatedness, and nature appreciation at the one-week and one-month follow-ups. Ratings of mystical-type experiences and awe, but not ego dissolution, during participants' ayahuasca sessions were weakly-to-moderately correlated with these increases. The number of ayahuasca ceremonies attended at the retreat was not related to change in outcomes, underscoring the importance of the quality rather than the quantity of the experiences in post-acute change. Lastly, participant age was negatively related to the occurrence of mystical-type experiences and awe, supporting literature indicating blunted psychedelic effects with increased age. In the context of study limitations, the results suggest that mystical-type experiences and awe occasioned by ayahuasca may be linked to prosocial changes in gratitude and relationships with nature that may be beneficial to mental health.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"171-180"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0