Journal of psychoactive drugs最新文献

Cultural Adaptation of Overdose Education Programs: Recommendations from Black Americans with Lived Experience of Opioid and Stimulant Use. 过量教育计划的文化适应：来自有阿片类药物和兴奋剂使用经验的黑人的建议。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-04-29 DOI: 10.1080/02791072.2026.2662464

Paris Wheeler, B Miller-Roenigk, K Jackson, A Smith, D Stevens-Watkins

{"title":"Cultural Adaptation of Overdose Education Programs: Recommendations from Black Americans with Lived Experience of Opioid and Stimulant Use.","authors":"Paris Wheeler, B Miller-Roenigk, K Jackson, A Smith, D Stevens-Watkins","doi":"10.1080/02791072.2026.2662464","DOIUrl":"https://doi.org/10.1080/02791072.2026.2662464","url":null,"abstract":"Black Americans have experienced disproportionate overdose deaths due to structural barriers inflicted by systemic racism, particularly among individuals who co-ingest opioids and stimulants. Despite efforts to improve overdose prevention resources on a national level, Black Americans continue to have lower access to naloxone for overdose reversal, are less likely to have received naloxone training, and have lower engagement in other overdose prevention strategies. Community engaged and culturally informed approaches are needed to ensure equitable provision of overdose education and naloxone distribution (OEND). Using empirically supported community engaged methods, the current study centers perspectives of stakeholders with lived experience to identify cultural adaptation needs for OEND programs that specifically target Black adults who use opioids and stimulants. Semi-structured qualitative focus groups revealed several themes that provide insights on cultural adaptation needs, including: centering Black overdose experiences, changes to structure and format, dispelling naloxone myths, coping strategies and alternatives to drug use, motivations for wellness, and sharing with others. Findings can inform more effective dissemination of OEND in Black communities impacted by high overdose rates.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship Between Alcohol Use, Blood Alcohol Concentration, and Road Traffic Accidents: A Scoping Review. 酒精使用、血液酒精浓度和道路交通事故之间的关系：一项范围综述。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-04-27 DOI: 10.1080/02791072.2026.2661581

Newfight Seth, Apinderjit Kaur, Siddharth Sarkar, Nishtha Chawla

{"title":"The Relationship Between Alcohol Use, Blood Alcohol Concentration, and Road Traffic Accidents: A Scoping Review.","authors":"Newfight Seth, Apinderjit Kaur, Siddharth Sarkar, Nishtha Chawla","doi":"10.1080/02791072.2026.2661581","DOIUrl":"https://doi.org/10.1080/02791072.2026.2661581","url":null,"abstract":"Background: The prevalence of road traffic accidents (RTAs) worldwide is a significant cause of death, with alcohol being a considerable risk factor. This scoping review aims to assess the prevalence of alcohol use among RTA victims and explore factors influencing these accidents.Methodology: Using PubMed and Google Scholar, studies on alcohol intake and its association with RTAs were identified, focusing on observational or exploratory quantitative research published in English-language peer-reviewed journals, examining country, setting, prevalence, and blood alcohol concentration levels.Results: A total of 33 studies (2005-2024) were included, with 2 focusing on RTA prevalence among alcohol users and 31 on alcohol use among RTA victims. Studies were predominantly retrospective. The prevalence of alcohol use among RTA victims varied between 18% and 78%, with higher rates in countries where alcohol is legal. Male RTA victims and pedestrians were more likely to have alcohol in their system, with many exceeding legal BAC limits.Conclusion: Alcohol use is highly prevalent among individuals involved in RTAs and severity is exacerbated by BAC levels exceeding legal limits; and pedestrians are equally vulnerable. Strengthening enforcement, preventive measures, and advanced technologies, along with global policies, can reduce alcohol-related accidents.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol and Native Language: Alcohol Use as a Coping Strategy for Intersectional Microaggressions Among Sexual and Gender Minoritized Latine Youth. 酒精和母语：酒精使用作为应对性和性别少数裔拉丁青年交叉微侵犯的策略。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-04-23 DOI: 10.1080/02791072.2026.2661582

Aldo Barrita, Roberto L Abreu, Iván Carbajal, Joshua G Parmenter, Ryan J Watson

{"title":"Alcohol and Native Language: Alcohol Use as a Coping Strategy for Intersectional Microaggressions Among Sexual and Gender Minoritized Latine Youth.","authors":"Aldo Barrita, Roberto L Abreu, Iván Carbajal, Joshua G Parmenter, Ryan J Watson","doi":"10.1080/02791072.2026.2661582","DOIUrl":"10.1080/02791072.2026.2661582","url":null,"abstract":"Intersectional microaggressions - daily slights toward individuals with multiple minoritized identities - pose significant stress for sexual and gender minoritized (SGM) Latine youth. Although research on these experiences has expanded, gaps remain regarding how they influence substance use and mental health across ethnic and linguistic lines. This study examined the relationship between intersectional microaggressions, psychological distress, and alcohol use as a coping strategy among a nationally diverse sample of SGM Latine youth (N = 3119). Participants completed surveys assessing experiences of microaggressions, mental health symptoms, and alcohol use. Mediation analyses revealed that intersectional microaggressions (predictor) were associated with higher psychological distress (mediator; B = .23, p < .001), which in turn were associated with higher alcohol use as a coping mechanism (outcome; B = .07, p < .001). Psychological distress partially mediated the association between microaggressions and alcohol use (direct effect B = .03, p < .001). A moderated mediation analysis, in which native language (Spanish or English) was tested as a moderator, showed greater indirect effects for native Spanish speakers than for native English speakers across both indirect paths in the mediation model. Findings underscore the compounded impact of intersectional discrimination on substance use and mental health in SGM Latine youth, with important implications for culturally and linguistically informed interventions targeting minoritized populations.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ayahuasca Therapy: Possible Reduction of Suicidal Ideation in Treatment-Resistant Depression - A Systematic Review. 死藤水疗法：可能减少治疗难治性抑郁症的自杀意念-一项系统综述。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-04-23 DOI: 10.1080/02791072.2026.2661580

Brayan Jonas Mano-Sousa, Maria Clara Gama Fontes, Ana Clara Anacleto Gonçalves, José Carlos Fernandes Galduróz, Joaquim Maurício Duarte-Almeida

{"title":"Ayahuasca Therapy: Possible Reduction of Suicidal Ideation in Treatment-Resistant Depression - A Systematic Review.","authors":"Brayan Jonas Mano-Sousa, Maria Clara Gama Fontes, Ana Clara Anacleto Gonçalves, José Carlos Fernandes Galduróz, Joaquim Maurício Duarte-Almeida","doi":"10.1080/02791072.2026.2661580","DOIUrl":"https://doi.org/10.1080/02791072.2026.2661580","url":null,"abstract":"Suicide, particularly in treatment-resistant depression (TRD), remains a pressing global health issue, with over 700,000 annual deaths. Existing treatments often have limited efficacy and delayed onset, creating a need for rapid-acting interventions. Ayahuasca, a traditional Amazonian psychedelic, has shown potential for rapidly reducing suicidal ideation. Our systematic review evaluated the clinical evidence regarding ayahuasca's effects on suicidality. From 6,633 initial records, five studies met the inclusion criteria. These studies, despite methodological heterogeneity, consistently demonstrate that ayahuasca administration is associated with rapid and significant reductions in suicidal ideation and depressive symptoms in patients with depressive disorders. The therapeutic effects were attributed to the synergistic action of β-carbolines and DMT present in ayahuasca. Neurobiologically, ayahuasca promotes neuroplasticity, partly through the upregulation of Brain-Derived Neurotrophic Factor, and modulates key brain networks, most notably by decreasing the activity of the Default Mode Network. Psychologically, this neural reconfiguration facilitates profound introspection, emotional processing, and transformative insights, which are central to its therapeutic effects. This review highlights the potential of ayahuasca as a novel therapeutic tool for suicidality but underscores the critical need for large-scale, methodologically rigorous longitudinal studies to establish definitive clinical guidelines for its safe and effective integration into psychiatric practice.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Manifestation of Structural Oppression Through Racial Trauma: Implications for Substance Use Among Black Adults. 结构性压迫在种族创伤中的表现：对黑人成人药物使用的影响。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-04-22 DOI: 10.1080/02791072.2026.2662462

Delisa G Brown, Priya K Johal, Alexandria G Bauer, Tanya C Saraiya

{"title":"The Manifestation of Structural Oppression Through Racial Trauma: Implications for Substance Use Among Black Adults.","authors":"Delisa G Brown, Priya K Johal, Alexandria G Bauer, Tanya C Saraiya","doi":"10.1080/02791072.2026.2662462","DOIUrl":"https://doi.org/10.1080/02791072.2026.2662462","url":null,"abstract":"Systemic racism and structural oppression are key drivers of health inequities, shaping substance use patterns and contributing to disproportionate harms among Black communities. While racial discrimination has been recognized as a chronic psychosocial stressor, its impact on substance use has rarely been examined through the lens of racial trauma - a critical psychological embodiment of structural oppression. This study investigates whether racial trauma symptoms mediate the relationship between racial discrimination and substance use (alcohol, tobacco, and cannabis) among Black adults. A sample of 183 Black/African American adults completed an online survey assessing experiences of racial discrimination, racial trauma symptoms, and substance use frequency. Mediation analyses using the PROCESS macro tested the direct and indirect effects of racial discrimination on substance use. Results showed that racial discrimination was significantly associated with greater alcohol, tobacco, and cannabis use. Racial trauma symptoms fully mediated the relationship between discrimination and alcohol use and partially mediated the relationships with tobacco and cannabis use. These findings highlight racial trauma symptoms as a key psychological mechanism through which systemic racism influences substance use behaviors. Integrating trauma-informed, culturally responsive prevention and treatment strategies is critical for reducing substance use disparities and advancing health equity for Black communities.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating Gendered Expectation: How Young Female Smokers in China Respond to Social Judgment. 性别期望导航：中国年轻女性吸烟者对社会评判的反应。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-04-20 DOI: 10.1080/02791072.2026.2662463

Liu Liu, Xiaotao Wang

{"title":"Navigating Gendered Expectation: How Young Female Smokers in China Respond to Social Judgment.","authors":"Liu Liu, Xiaotao Wang","doi":"10.1080/02791072.2026.2662463","DOIUrl":"https://doi.org/10.1080/02791072.2026.2662463","url":null,"abstract":"Smoking has traditionally been associated with masculinity in Chinese society, making it more socially acceptable for men while subjecting female smokers to greater scrutiny and stigma. However, the number of female smokers, especially young women, has been steadily increasing in recent years due to rapid urbanization, globalization, and shifting gender norms. The tension between modernity and tradition means that female smokers in China must navigate a complex social environment, where their choices are increasingly recognized yet remain subject to criticism. Based on semi-structured interviews with 27 young female smokers, the findings of this study confirm that young women in contemporary Chinese society continue to face negative judgment from various social groups, whereas their male counterparts do not. Nevertheless, despite prevailing social judgment, the growing number of female smokers suggests that more women are challenging the stereotype of smoking as \"deviant\" behavior and embracing it as a personal choice. By highlighting the various strategies young female smokers employ to navigate societal criticism, this study offers valuable insights into how they manage and respond to negative perceptions. This balancing act reflects the ongoing tension between evolving social attitudes and deeply ingrained cultural norms regarding gender and smoking in China.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-03-26 DOI: 10.1080/02791072.2026.2644852

Nhi Nguyen, Paola N Cruz Rivera, Dania Abu Baker, Rekha Narasimhan, Lize Tibiriçá, Wayne Kepner, Pearse O'Malley, Lynette Zhao, Annie L Nguyen, Alison A Moore

{"title":"Behaviors Related to Medical Cannabis Use in Older Adults: A Qualitative Study.","authors":"Nhi Nguyen, Paola N Cruz Rivera, Dania Abu Baker, Rekha Narasimhan, Lize Tibiriçá, Wayne Kepner, Pearse O'Malley, Lynette Zhao, Annie L Nguyen, Alison A Moore","doi":"10.1080/02791072.2026.2644852","DOIUrl":"https://doi.org/10.1080/02791072.2026.2644852","url":null,"abstract":"There is a growing interest in medical cannabis use among older adults. This qualitative study aims to explore behaviors related to medical cannabis use among older adults living in Southern California. Adults aged ≥65 years who reported medical cannabis use in the past 6 months completed a survey followed by a semi-structured, qualitative interview. Interviews were transcribed verbatim, coded using NVivo Software, and analyzed for emergent themes. Nineteen participants (52.6% women, mean age = 75 ± 6.5 years) completed the survey and interview. Participants described frequent and chronic use of cannabis, and self-experimentation with medical cannabis due to a lack of guidance on its use. They also used medical cannabis in place of or in conjunction with other medications and timed its use to reduce risks of drug interactions. Almost all expressed minimal concerns about cannabis use disorder, although nearly one-third (31.6%) screened positive for cannabis use disorder. Overall, there is inadequate knowledge of medical cannabis use among older adults, suggesting a need for improved access to reliable information and education on the topic. Understanding older adults' medical cannabis use behaviors will help clinicians provide appropriate counseling and monitoring for this population.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychedelics and Mental Health in Endurance Athletes: A Cross-Sectional Study in Brazil. 迷幻药与耐力运动员的心理健康：巴西的一项横断面研究。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-03-20 DOI: 10.1080/02791072.2026.2644865

Marina A M Portes, Leandro J Bertoglio

{"title":"Psychedelics and Mental Health in Endurance Athletes: A Cross-Sectional Study in Brazil.","authors":"Marina A M Portes, Leandro J Bertoglio","doi":"10.1080/02791072.2026.2644865","DOIUrl":"https://doi.org/10.1080/02791072.2026.2644865","url":null,"abstract":"Psilocybin, N,N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD), and 3,4-methylenedioxymethamphetamine (MDMA) are psychedelic compounds with therapeutic potential for depression, anxiety, and post-traumatic stress. However, their relevance to endurance athletes, who face particular psychological and physical stressors, remains underexplored. This study combines a conceptual overview with cross-sectional survey data from Brazilian endurance athletes. Twenty-eight participants completed a questionnaire addressing mental health, use of supplements, medications, and psychoactive substances, as well as perceptions and attitudes toward psychedelics and psychedelic therapies. The mean age was 37 ± 10 years. Women more frequently reported pharmacological treatment for depression or anxiety. Overall, 64% reported a lack of mental health support in their athletic environments; 11% had prior psychedelic experience, while 79% expressed openness to psychedelic therapies if legal and supervised. However, 61% were unaware of existing evidence for psychedelics in treating mental health conditions. Their potential anti-inflammatory and analgesic properties were similarly unrecognized and unexpected. Misconceptions were common: 78% believed psychedelics to be addictive. Despite this, attitudes toward their therapeutic potential were generally positive. These findings reveal unmet mental health needs, significant knowledge gaps, and widespread misconceptions among endurance athletes, suggesting the value of targeted, evidence-based education to support informed consideration of psychedelic therapies.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-15"},"PeriodicalIF":2.2,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ayahuasca and Public Health III: Health Status of a Sample of Ayahuasca Ceremony Attenders in Portugal. 死藤水与公众健康III：葡萄牙死藤水仪式参与者样本的健康状况。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-03-19 DOI: 10.1080/02791072.2026.2631378

Pedro J Teixeira, Jorge Encantado, Helena D Amaro, Diogo Veiga, Laura C Carvalho, Miguel Ángel Alcázar-Córcoles, Jaime Hallak, Rafael Guimarães Dos Santos, José Carlos Bouso, Maja Kohek

{"title":"Ayahuasca and Public Health III: Health Status of a Sample of Ayahuasca Ceremony Attenders in Portugal.","authors":"Pedro J Teixeira, Jorge Encantado, Helena D Amaro, Diogo Veiga, Laura C Carvalho, Miguel Ángel Alcázar-Córcoles, Jaime Hallak, Rafael Guimarães Dos Santos, José Carlos Bouso, Maja Kohek","doi":"10.1080/02791072.2026.2631378","DOIUrl":"https://doi.org/10.1080/02791072.2026.2631378","url":null,"abstract":"Ayahuasca, a traditional Amazonian psychoactive brew, has gained increasing attention for its potential health benefits; however, no previous research has investigated its use in Portugal. This study aims to evaluate the health status, lifestyle behaviors, and psychosocial well-being of Portuguese ayahuasca users, comparing their self-reported health indicators with population norms. A cross-sectional online survey was conducted among 203 Portuguese adults who have participated in ayahuasca ceremonies. Participants completed validated measures assessing general health status, mental health, coping strategies, and social support. Results were compared to national health survey data. Ayahuasca users perceive their health as good or very good, with lower rates of chronic disease and obesity compared to the general population. Participants also report greater physical activity levels, lower alcohol consumption, and enhanced psychological well-being. A substantial proportion of users attributed positive lifestyle changes, reductions in substance use, and lower reliance on prescription medication to their ayahuasca experiences. Results reinforce previous research linking ayahuasca use to health and well-being, showing that ceremony attenders in Portugal display a range of beneficial lifestyle behaviors and health indicators. Future research should employ longitudinal designs to better understand the causal pathways linking ayahuasca use to health outcomes and explore potential public health implications.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selection Bias in Psychedelic Research: Comparing Self-Reported Quality-Of-Life Impact Between Enthusiasts and a General Population Sample. 迷幻药研究中的选择偏差：比较狂热者和一般人群样本之间自我报告的生活质量影响。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-03-18 DOI: 10.1080/02791072.2026.2644856

Jonathan Bendz, Linus Schäfer, David Sjöström, Sverker Sikström, Petri Kajonius

{"title":"Selection Bias in Psychedelic Research: Comparing Self-Reported Quality-Of-Life Impact Between Enthusiasts and a General Population Sample.","authors":"Jonathan Bendz, Linus Schäfer, David Sjöström, Sverker Sikström, Petri Kajonius","doi":"10.1080/02791072.2026.2644856","DOIUrl":"https://doi.org/10.1080/02791072.2026.2644856","url":null,"abstract":"Psychedelic experiences have been associated with improved quality of life, but many studies rely on samples of enthusiasts, raising concerns about selection bias. This study examined whether self-reported quality-of-life impact differed between a convenience sample of psychedelic enthusiasts and a general population sample recruited through Prolific, and whether sample differences persisted after controlling for mindset, setting, motivation, and personality. A total of N = 1,182 participants (N = 583 enthusiasts; N = 599 general sample) with prior psychedelic experience completed an online survey assessing perceived impact, contextual factors, motivation for use, and Big Five personality. Between-group differences were analyzed using Welch's t-tests, Pearson´s chi-squared tests and Mann-Whitney-Wilcoxon tests. A Type III ANCOVA was used to assess whether sample differences in quality-of-life impact remained after controlling for relevant covariates. Enthusiasts reported significantly greater quality-of-life impact (d = 0.84), higher openness, extraversion and agreeableness, more favorable mindsets and settings, and a higher frequency of personal growth motives. In the ANCOVA, sample membership was the strongest predictor of quality-of-life impact, followed by setting, motivation, openness, and mindset. These findings provide empirical clarification of how enthusiast-leaning recruitment strategies can shape reported outcomes in psychedelic research. Results underscore the need to consider sampling frames when interpreting reported benefits and to prioritize representative recruitment in future psychedelic research.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0