Jun Sung Hong, Serim Lee, Diana M DiNitto, Björn Sjögren, Robert Thornberg, Brandon Terrell
{"title":"Racial/Ethnic and Sexual Identity Differences in the Associations Between School Bullying and Cyberbullying Victimization and Types of Substance Use.","authors":"Jun Sung Hong, Serim Lee, Diana M DiNitto, Björn Sjögren, Robert Thornberg, Brandon Terrell","doi":"10.1080/02791072.2026.2743931","DOIUrl":"https://doi.org/10.1080/02791072.2026.2743931","url":null,"abstract":"<p><p>Bullying victimization is found to be associated with substance use, and this association is relevant to racial/ethnic minority and sexual minority (lesbian, gay, and bisexual) adolescents. However, few studies have focused on the role of intersectionality in the linkage between bullying victimization and substance use. The current research explores the relationship between school- and cyberbullying victimization and various types of substance use among a racially/ethnically diverse sample of heterosexual, lesbian, gay, and bisexual adolescents. The 2023 Youth Risk Behavior Surveillance System Combined High School Dataset was used. The sample consisted of 12,713 White, Black, and Hispanic heterosexual, lesbian, gay, and bisexual adolescents. School bullying victimization was associated with higher alcohol, marijuana, and opioid use, but lower tobacco use, whereas cyberbullying victimization was associated with higher use of all substances examined. Interaction analyses indicated that Hispanic bisexual and Hispanic heterosexual adolescents experienced steeper increases in the predicted probability of alcohol use associated with bullying victimization and cyberbullying victimization compared to White heterosexual adolescents. In addition, Hispanic heterosexual identity moderated the associations between school bullying victimization and opioid use, as well as between cyberbullying victimization and tobacco use.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychedelic Drug Use and Romantic Relationship Functioning.","authors":"Robert Hutto, Nicole Amada, Jacob Shane","doi":"10.1080/02791072.2026.2743939","DOIUrl":"https://doi.org/10.1080/02791072.2026.2743939","url":null,"abstract":"<p><p>Romantic relationship quality is closely tied to individual outcomes, with higher quality relationships corresponding to better mental and physical health. Illicit drug use is known to associate with relationship dysfunction, however literature on this topic largely ignores or conflates psychedelics with other illicit drugs. The present study compared relationship functioning among people who reported past-year psychedelic use, stimulant/opioid use, and nonuse of illicit drugs using data from the National Couples' Health and Time Study (NCHAT). Those who indicated psychedelic use did not differ from those who indicated no drug use on most outcomes, though they reported lower commitment. Those who reported stimulant/opioid use demonstrated worse functioning than those who reported no drug use, showing lower satisfaction, worse dyadic coping, higher marital risk, more negative interactions, and higher odds of perpetrating intimate partner abuse. Between those who disclosed drug use, people who reported psychedelic use indicated fewer negative interactions and lower odds of perpetrating intimate partner abuse than people who reported stimulant/opioid use, with trends toward greater couples satisfaction and better dyadic coping. These findings suggest that people who choose to use psychedelics exhibit meaningful differences in interpersonal functioning than those who use illicit stimulants and opioids.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Introduction to the Special Issue on the Impacts of Systemic Racism and Structural Oppression on Overdose and Substance Use Inequities.","authors":"Juan Carlos Gonzalez, Caravella McCuistian","doi":"10.1080/02791072.2026.2745437","DOIUrl":"https://doi.org/10.1080/02791072.2026.2745437","url":null,"abstract":"<p><p>This special issue of the <i>Journal of Psychoactive Drugs</i>, titled \"Confronting the Impacts of Systemic Racism and Structural Oppression on Overdose and Substance Use Inequities,\" addresses the disproportionate burden of drug overdose and substance use impacts borne by Black, Indigenous, and People of Color (BIPOC) communities. While overall overdose mortality rates have fluctuated, deep racial inequities persist and are driven in part by structural oppressive forces, systemic and structural racism, and White supremacy. To move beyond traditional risk-factor epidemiology and reductive \"gap gazing,\" this collection highlights critical empirical approaches that directly measure and confront systemic harms while advancing equitable solutions. The issue features two central themes. The first theme, Measuring the Impact of Structural and/or Systemic Factors, highlights rigorous quantitative and qualitative studies that operationalize intersectional stress, racial trauma, and lifespan violence among minoritized populations. The second theme, Culturally Responsive Substance Use/Overdose Prevention, focuses on community-informed adaptations to overdose education and therapeutic settings to combat stigma and mitigate racial microaggressions. Ultimately, this issue demonstrates how critical scientific frameworks can transform substance use scholarship. By centering in the margins, evaluating evolving therapeutic interventions through an equity lens, and demanding methodological precision in documenting structural harms, this issue offers a path forward toward health justice and accountability for all people who use substances.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-5"},"PeriodicalIF":2.4,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Usman, Sara Castiglioni, Noelia Salgueiro-Gonzalez, Donatella Nardiello, Maurizio Quinto
{"title":"Multi-Indicator Surveillance of Amphetamine-Type Stimulants (ATS) and Synthetic Cathinones in Italy: A Systematic Review of Seizure, Wastewater, and Toxicological Data.","authors":"Muhammad Usman, Sara Castiglioni, Noelia Salgueiro-Gonzalez, Donatella Nardiello, Maurizio Quinto","doi":"10.1080/02791072.2026.2729623","DOIUrl":"https://doi.org/10.1080/02791072.2026.2729623","url":null,"abstract":"<p><p>Synthetic stimulant drugs in Italy are evolving rapidly, with amphetamine-type stimulants (ATS) and synthetic cathinones (SC) representing a growing public health challenge. However, no previous study has integrated multiple surveillance indicators to assess the availability and consumption of these substances across Italy. This systematic review synthesized comprehensive evidence published between 2000 and 2023 from three monitoring indicators: drug seizures reports, wastewater-based epidemiology (WBE), and toxicological/clinical studies. Searches of Scopus, PubMed, and Google Scholar identified 969 records, of which 49 studies and reports met the inclusion criteria: 15 on drug seizures, 18 on WBE, and 16 on toxicological studies. Eligible articles were fully reviewed and summarized. Results indicated a diverse and evolving landscape, with increasing detection of synthetic cathinones and significant regional variation in ATS and SC consumption. In total, seven ATS and twenty-five SC were identified across all indicators. Amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), 4-methylethcathinone (4-MEC), and methylenedioxypyrovalerone (MDPV) were consistently detected in seizure, wastewater, and toxicological data, indicating their availability and consumption in Italy. WBE studies showed marked spatial and temporal variability in stimulant consumption, while seizure and toxicological data highlighted the increasing diversification of synthetic cathinones in the Italian drug market. Key limitations include uneven geographical coverage and methodological heterogeneity among studies. The findings demonstrate the value of integrating WBE, forensic, and law enforcement indicators to strengthen surveillance of emerging stimulant drugs in Italy.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-17"},"PeriodicalIF":2.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From Counseling Microaggressions to Substance Use: Indirect Pathways Through Help-Seeking and Psychological Distress.","authors":"Amudha Balaraman, Alexandria G Bauer","doi":"10.1080/02791072.2026.2673848","DOIUrl":"https://doi.org/10.1080/02791072.2026.2673848","url":null,"abstract":"<p><p>Racial-ethnic minoritized individuals face persistent disparities in mental health service utilization, which are shaped by structural and interpersonal racism. This study examined whether racial microaggressions in counseling were indirectly associated with substance use through their impact on help-seeking intentions and psychological distress. A serial mediation model was tested using self-report data from a community-based sample of racial-ethnic minoritized adults (<i>N</i> = 223). Results indicated that prior experiences of racial microaggressions in counseling were associated with lower help-seeking intentions, which in turn were linked to greater psychological distress and increased substance use. Although the total effect of racial microaggressions on substance use was not significant, the indirect pathway was significant, underscoring the importance of examining mediating mechanisms that impact substance use outcomes. These findings highlight how interpersonal racism in therapeutic settings may contribute to adverse mental health outcomes and emphasize the need for culturally humble, affirming mental health care. Implications for clinical practice and equity are discussed using frameworks from Critical Race Theory and the Social Determinants of Health framework.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D L Mizelle, P B Wheeler, R L Peterson, N Malone, A B Smith, D Stevens-Watkins
{"title":"The Carceral System's Role in Opioid Misuse and Overdose Risk Among Black Men: A Qualitative Analysis.","authors":"D L Mizelle, P B Wheeler, R L Peterson, N Malone, A B Smith, D Stevens-Watkins","doi":"10.1080/02791072.2026.2696254","DOIUrl":"https://doi.org/10.1080/02791072.2026.2696254","url":null,"abstract":"<p><p>Overdose rates among Black men have increased fourfold since 2015. Several systemic factors contribute to Black men's opioid use outcomes, including the impact of the carceral system. Given the heightened risk of opioid overdose upon release from incarceration, there is a need to examine the structural impact of incarceration on opioid use among Black men. Thus, the current study examines the incarceration experiences of 20 Black men who use opioids to better understand how these experiences influence their drug use. The reflexive thematic analysis revealed five key themes: (1) Socialization of Carceral Systems Throughout Development, (2) Varied relationships of Opioids While Incarcerated, (3) Access to Treatment Programs/Resources While Incarcerated, (4) Cycle of Incarceration, Racism, and Illicit Opioid Use, and (5) No Implication. These themes and respective subthemes demonstrate the significant and pervasive impact of the carceral system on Black men's opioid use experiences and trajectories, for many shaping patterns of opioid use during incarceration and following release. Considerations for researchers and practitioners are provided based on the study findings.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omer A Syed, Rotem Petranker, Sean M Nestor, Muhammad Ishrat Husain, Nir Lipsman, Fahad Alam, Peter Giacobbe, Stephanie Lake, Philippe Lucas
{"title":"Real-World Therapeutic Use of Ketamine in Clinical and Non-Clinical Settings: A Cross-Sectional Survey.","authors":"Omer A Syed, Rotem Petranker, Sean M Nestor, Muhammad Ishrat Husain, Nir Lipsman, Fahad Alam, Peter Giacobbe, Stephanie Lake, Philippe Lucas","doi":"10.1080/02791072.2026.2730550","DOIUrl":"https://doi.org/10.1080/02791072.2026.2730550","url":null,"abstract":"<p><p>The use of ketamine as a treatment for mood disorders continues to grow in popularity. However, the differences between individuals consuming ketamine within clinical settings and those self-medicating in casual, non-clinical settings has not been yet characterized. Using the 2023 Global Psychedelic Survey, this study aimed to examine the demographic and clinical characteristics, as well as the self-reported effectiveness and hallucination-related side effects, of ketamine use by comparing individuals using ketamine with and without medical supervision. Compared to clinical ketamine consumers (<i>n</i> = 238), non-clinical consumers (<i>n</i> = 222) were more experienced in use of various psychedelic (<i>p</i> < .0001) and non-psychedelic recreational substances (<i>p</i> < .001), and lifetime use of ketamine (<i>p</i> < .0001). Both groups presented with similar mild depression and anxiety symptoms at the time of the survey collection (<i>p</i> = .22, <i>p</i> = .46). Ketamine was similarly and highly rated in effectiveness within both groups when rated on a scale of 0-100 (83.3 ± 15.0 clinical, 81.2 ± 16.6 non-clinical; <i>p</i> = .45). Non-clinical consumers presented higher odds of reporting long-term hallucinations following ketamine use (OR = 2.58, 95% CI: 1.08-6.31). The results of this study indicate a high self-reported effectiveness of ketamine in clinical and non-clinical settings while emphasizing the potential risks of side effects when used without medical supervision.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-15"},"PeriodicalIF":2.4,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suzana Mat Isa, Aini Ismafairus Abd Hamid, Muhamad Zabidi Ahmad, Muhammad Riddha Abdul Rahman, Mohammad Farris Iman Leong Abdullah, Darshan Singh
{"title":"Cerebellar Alteration in Resting-State Functional Connectivity Among Kratom (<i>Mitragyna speciosa</i>) Users: Insights from Functional MRI.","authors":"Suzana Mat Isa, Aini Ismafairus Abd Hamid, Muhamad Zabidi Ahmad, Muhammad Riddha Abdul Rahman, Mohammad Farris Iman Leong Abdullah, Darshan Singh","doi":"10.1080/02791072.2026.2729619","DOIUrl":"https://doi.org/10.1080/02791072.2026.2729619","url":null,"abstract":"<p><p>Due to the psychotropic properties of kratom (<i>Mitragyna speciosa</i>), further studies are needed to measure its neurobiological impacts. This exploratory study employed resting-state functional magnetic resonance imaging (rs-fMRI) to examine alterations in brain activity and functional connectivity (FC) among kratom users. A total of 43 respondents were recruited (22 regular kratom users and 21 healthy controls). RS-fMRI data were acquired using a 1.5T GE Signa HDxt scanner. Preprocessing and analysis were performed with Statistical Parametric Mapping 12 (SPM 12) and CONN toolbox. Group differences in the low-frequency fluctuations (LFFs) and FC were examined. Kratom users exhibited reduced LFF in brain regions critical to the default mode network (DMN), cognitive control, and self-referential processing, including the precuneus, superior frontal gyrus, and cerebellar and cingulate cortices. They also showed increased FC between salience and cerebellar networks, specifically in the posterior cerebellum, and left rostral prefrontal cortex (RPFC). Chronic kratom consumption may alter brain activity, especially in areas linked to the DMN, cognition, and reward processing. Enhanced FC between salience and cerebellar networks may reflect compensatory mechanisms or adaptations to kratom's effects. Further research is crucial to elucidate the underlying mechanisms and potential implications for cognitive function and addictive behaviors.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.4,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erika T H Lutz, Dustin Sulak, Leigh Vinocur, Ethan B Russo, Carrie Cuttler
{"title":"A Survey of Cannabigerol User's Patterns of Use, Perceived Efficacy and Satisfaction.","authors":"Erika T H Lutz, Dustin Sulak, Leigh Vinocur, Ethan B Russo, Carrie Cuttler","doi":"10.1080/02791072.2026.2727651","DOIUrl":"https://doi.org/10.1080/02791072.2026.2727651","url":null,"abstract":"<p><p>Cannabigerol (CBG) and the acidic form of CBG (cannabigerolic acid, CBGA) are becoming increasingly more available and popular, with pre-clinical rodent research suggesting these compounds have an array of therapeutic effects. However, there have been few clinical trials or surveys examining their effects in humans. We conducted a survey of 239 CBG/CBGA users to assess the medical conditions they use CBG/CBGA to manage, as well as their perceived efficacy and satisfaction with CBG/CBGA for managing these conditions. Participants also reported on their typical use patterns (e.g. typical dose), their perceived time to feel effects, and duration of those effects. The top five conditions participants reported using CBG/CBGA to manage were insomnia/disturbed sleep (62%), inflammatory chronic pain (44%), anxiety (33%), episodic pain (29%), and neuropathic chronic pain (28%), with participants generally reporting that CBG/CBGA \"slightly improves\" to \"much improves\" their symptoms. Participants reported typically using a dose of 10-12 mg of CBG and they indicated that they feel effects within 15-60 min of oral ingestion and that these effects persist for 4-6 h. These findings will help inform consumers of CBG as well as researchers designing clinical trials to investigate the effects of CBG on humans in a more objective manner.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Wyndham Lawrence, Manoj K Doss, Akira Robert O'Connor
{"title":"Characterizing Psychedelic-Evoked Familiarity: A Comparative Study with Autobiographical and Déjà Vu Experiences.","authors":"David Wyndham Lawrence, Manoj K Doss, Akira Robert O'Connor","doi":"10.1080/02791072.2026.2729618","DOIUrl":"https://doi.org/10.1080/02791072.2026.2729618","url":null,"abstract":"<p><p>Psychedelic experiences often evoke a sense of familiarity, an experiential quality that has received little empirical attention despite its potential therapeutic and cognitive significance. This study examined psychedelic-evoked familiarity in comparison to non-drug-induced forms of familiarity, including autobiographical and déjà vu experiences. An anonymous online survey was administered to 1050 participants, who completed the Sense of Familiarity Questionnaire (SOFQ) and psycho-emotional ratings for at least one of three experiences: Psychedelic, Autobiographical, or <i>Déjà Vu</i>. Across all SOFQ items, Psychedelic experiences were rated significantly higher in familiarity, particularly within the \"Familiarity with Transcendent Features\" category. Psychedelic experiences were also associated with greater emotional intensity, novelty, and comfort, with no increased anxiety, relative to the other experience types. Classic psychedelics generally elicited strong familiarity, while psycho-emotional responses varied across psychedelic types. Most participants described the familiarity as authentic and positively impactful, and approximately half reported enduring effects such as emotional transformation, interconnectedness, and reduced fear of death. These findings suggest that psychedelic-evoked familiarity is phenomenologically different from autobiographical and déjà vu familiarity. Psychedelic-evoked familiarity warrants further investigation to determine whether it serves as a phenomenological driver of the enduring psychological and existential benefits associated with psychedelic experiences.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-16"},"PeriodicalIF":2.4,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}