Journal of psychoactive drugs最新文献

Correction. 修正。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-27 DOI: 10.1080/02791072.2025.2498792

引用次数: 0

Exploring Factors Affecting Psychological Flexibility After Psychedelic Experiences. 探索影响迷幻体验后心理灵活性的因素。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-25 DOI: 10.1080/02791072.2025.2495937

B Romeo, E Kervadec, B Fauvel, L Strika-Bruneau, A Amirouche, V Verroust, P Piolino, A Benyamina

{"title":"Exploring Factors Affecting Psychological Flexibility After Psychedelic Experiences.","authors":"B Romeo, E Kervadec, B Fauvel, L Strika-Bruneau, A Amirouche, V Verroust, P Piolino, A Benyamina","doi":"10.1080/02791072.2025.2495937","DOIUrl":"https://doi.org/10.1080/02791072.2025.2495937","url":null,"abstract":"Neurobiological effects and psychological models propose that psychedelics may promote psychological flexibility, suggesting a transdiagnostic effect by disrupting maladaptive patterns. The objective of this study was therefore to investigate the determinants of psychological flexibility change following a psychedelic use. This retrospective online survey included French individuals who had undergone a significant psychedelic experience. Participants were assessed for mystical experience intensity with the MEQ-30, and psychological flexibility via the AAQ-II, at three retrospective time points. Data analysis comprised descriptive statistics, correlation analysis, ANCOVA to evaluate the impact of psychedelic use variables on psychological flexibility, and linear regression to identify predictors of psychological flexibility changes. Data showed a positive correlation between mystical experience intensity and improvements in psychological flexibility, especially 1-month post-experience (p < .01), and during the 6 months before the survey (p < .01). Key predictors of changes in psychological flexibility included baseline AAQ-II scores, MEQ total scores and frequent psychedelic use, underlining the interaction between personal and experiential factors in determining therapeutic outcomes. In conclusion, this study highlights how the intensity of mystical experience and baseline psychological flexibility may be the key factors influencing changes in psychological flexibility post-psychedelic use, suggesting a potential therapeutic value.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-12"},"PeriodicalIF":2.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial Differences in Naturalistic Psychedelic Use - Motivations for Use, Communication with Health Care Providers, and Outcomes. 自然致幻剂使用的种族差异——使用动机、与卫生保健提供者的沟通和结果。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-22 DOI: 10.1080/02791072.2025.2491381

Nicolas G Glynos, Mallet R Reid, Jacob S Aday, Daniel J Kruger, Kevin F Boehnke, Stephanie Lake, Philippe Lucas

{"title":"Racial Differences in Naturalistic Psychedelic Use - Motivations for Use, Communication with Health Care Providers, and Outcomes.","authors":"Nicolas G Glynos, Mallet R Reid, Jacob S Aday, Daniel J Kruger, Kevin F Boehnke, Stephanie Lake, Philippe Lucas","doi":"10.1080/02791072.2025.2491381","DOIUrl":"https://doi.org/10.1080/02791072.2025.2491381","url":null,"abstract":"People of Color have been under-included in psychedelic-assisted therapy (PAT) research. Researchers have argued that systemic issues resulting in harms to communities of color like the War on Drugs and recurrent exposure to discrimination in healthcare settings may reduce their willingness to engage in PAT research. However, there are no empirical data regarding People of Color's trust or willingness in using psychedelics with support of trained healthcare providers. Therefore, we analyzed data from a large-scale survey of people using psychedelics to explore interactions between People of Color and healthcare providers in North America. The sample included 3,547 White people, 448 People of Color, and 377 Multiracial people. A lower proportion of People of Color consumed psychedelics with the support of a trained provider but an equal proportion had disclosed psychedelic use to primary care providers. Further, People of Color were equally motivated to use psychedelics with a trained healthcare provider, used psychedelics to treat similar issues, and similarly reported psychedelics as effective with other groups. Our findings suggest that lack of trust may not fully explain the underrepresentation of People of Color in PAT research, and future studies should investigate other barriers to People of Color's inclusion in PAT research.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-12"},"PeriodicalIF":2.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not Losing Momentum: Cross-Sectional Insights into Ibogaine Clinical Trials. 不失势头：伊博加因临床试验的横断面洞察。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-18 DOI: 10.1080/02791072.2025.2491385

Damian Swieczkowski, Aleksander Kwaśny, Krzysztof Sadko, Wiesław Jerzy Cubała

{"title":"Not Losing Momentum: Cross-Sectional Insights into Ibogaine Clinical Trials.","authors":"Damian Swieczkowski, Aleksander Kwaśny, Krzysztof Sadko, Wiesław Jerzy Cubała","doi":"10.1080/02791072.2025.2491385","DOIUrl":"https://doi.org/10.1080/02791072.2025.2491385","url":null,"abstract":"Ibogaine, a non-classical psychedelic, has gained increasing attention as a potential treatment for substance use disorders (SUD); however, a lack of commercial interest and safety-related concerns limit its clinical development. This cross-sectional study investigates the current landscape of clinical trials involving ibogaine, a non-classical psychedelic, focusing on its safety and efficacy. We extracted data from ClinicalTrials.Gov, EU Clinical Trials (https://euclinicaltrials.eu/), the EU Clinical Trials Register (https://www.clinicaltrialsregister.eu/), and the International Clinical Trials Registry Platform (World Health Organization). After rigorous screening and deduplication, we analyzed nine trials. Our findings revealed considerable variability in methodologies, including fixed-dose and ascending-dose designs, diverse inclusion and exclusion criteria, and differing primary and secondary outcomes. Early-phase trials dominate, primarily focusing on pharmacokinetics, withdrawal symptom reduction, and safety monitoring. Key findings indicate significant differences in how safety concerns are addressed, particularly regarding ibogaine's cardiovascular risk. While preliminary evidence suggests potential therapeutic benefits, the absence of large-scale, late-phase trials limits definitive conclusions. Our study underscores the need for a standardized clinical framework to ensure reliable assessments of ibogaine's efficacy and safety. Lessons from research on classical psychedelics, and MDMA could help improve trial design and reduce issues related to blinding and expectancy bias.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ayahuasca Retreats: The Role of Awe and Mystical Experiences in Well-Being. 死藤水静修：敬畏和神秘体验在幸福中的作用。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-04-16 DOI: 10.1080/02791072.2025.2491378

Brant Maclean, Amy Wilson, Andrew Allen, Vikki Schaffer, Lee Kannis-Dymand

{"title":"Ayahuasca Retreats: The Role of Awe and Mystical Experiences in Well-Being.","authors":"Brant Maclean, Amy Wilson, Andrew Allen, Vikki Schaffer, Lee Kannis-Dymand","doi":"10.1080/02791072.2025.2491378","DOIUrl":"https://doi.org/10.1080/02791072.2025.2491378","url":null,"abstract":"Research on the positive psychological effects of psychedelics has surged since the early 2000s, particularly regarding increased well-being. Studies have demonstrated how psychedelic-occasioned mystical experiences play a key role in their positive effects, which has prompted an interest in the emotion of awe in the psychedelic context due to its similar phenomenology and associated benefits. This study examined 60 individuals following their visitation to at least one ayahuasca retreat in a country where ayahuasca use was legal or retreats are approved to use ayahuasca, hypothesizing that not only high levels of awe but mystical experiences characterized by high levels of awe would be significantly associated with higher well-being. Neither hypothesis was supported: higher levels of mystical experience with lower perceived vastness, a facet of awe, was significantly associated with higher well-being, possibly highlighting the synergistic relationship between mystical experiences and perceived vastness on well-being. The study has implications for future research, particularly in terms of understanding how the perceived vastness of a person's psychedelic experience may be modulated to mitigate distress and foster well-being.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilizing Psychedelics to Enhance Well-Being: A Systematic Review. 利用致幻剂提高幸福感：一项系统综述。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-03-31 DOI: 10.1080/02791072.2025.2484380

Samuel Thomson, Nikos Thomacos

{"title":"Utilizing Psychedelics to Enhance Well-Being: A Systematic Review.","authors":"Samuel Thomson, Nikos Thomacos","doi":"10.1080/02791072.2025.2484380","DOIUrl":"https://doi.org/10.1080/02791072.2025.2484380","url":null,"abstract":"Psychedelic-assisted therapy is gaining recognition for its potential to enhance human functioning. While most research has focused on psychedelic' therapeutic use for mental illness, this review applies the PERMA Theory of Well-Being to systematically examine their role in enhancing well-being in healthy individuals. The final search of five academic databases was conducted on February 4, 2024, including studies published from 1994. After applying the inclusion criteria (controlled or naturalistic experimental design with an outcome measurement at least 7 days post-consumption), 19 studies were included. Encompassing 949 participants, two studies involved 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), seven ayahuasca, two lysergic acid diethylamide (LSD), and eight psilocybin. Results consistently indicate psychedelic consumption is related to enduring enhancements in PERMA's five elements of well-being, including positive emotions, engagement, relationships, meaning, and accomplishment. While discussion of adverse effects was frequently absent, no serious adverse effects were reported in six studies. Future research should address the limitations of the included studies by conducting larger-scale, longitudinal randomized controlled trials that incorporate a comprehensive assessment of well-being. Nevertheless, the findings of this systematic review call for a paradigm shift, moving beyond a disease-focused lens to recognizing psychedelics' capacity to enhance well-being in healthy individuals, ultimately fostering human flourishing.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-17"},"PeriodicalIF":2.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors of Psychoactive Substance Use Behaviors and Intention Among Social Workers' Adolescent Case-Work Clients in Hong Kong. 香港青少年社工个案服务对象精神活性物质使用行为及意向的影响因素

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-03-30 DOI: 10.1080/02791072.2025.2483701

Yanqiu Yu, Nick Tse, Tsun Kwan Mary Ip, Phoenix K H Mo, Joseph T F Lau

{"title":"Factors of Psychoactive Substance Use Behaviors and Intention Among Social Workers' Adolescent Case-Work Clients in Hong Kong.","authors":"Yanqiu Yu, Nick Tse, Tsun Kwan Mary Ip, Phoenix K H Mo, Joseph T F Lau","doi":"10.1080/02791072.2025.2483701","DOIUrl":"https://doi.org/10.1080/02791072.2025.2483701","url":null,"abstract":"Based on Social Cognitive Theory (SCT), this study investigated the factors of psychoactive substance use in terms of current use (past 30 days), lifetime use, and behavioral intention (next 12 months) in Hong Kong adolescent case-clients of social workers from July 2021 to June 2022. The prevalence of current/lifetime psychoactive substance use and behavioral intention to use psychoactive substances was 7.6%/20.9% and 8.6%, respectively. The SCT constructs of positive outcome expectancy of psychoactive substance use, the observational learning indicators, and the environmental factor (easiness to obtain psychoactive substances) were positively associated with current and lifetime psychoactive substance use. Similar associations involving negative outcome expectancy (NOE), emotional relief refusal self-efficacy (RSE), and opportunistic RSE were significant and negative. Furthermore, NOE, emotional relief RSE, and social facilitation RSE were significantly associated with behavioral intention of psychoactive substance use. Future longitudinal studies are warranted to confirm the findings and test pilot interventions.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction and Standardization of Perceived Shame Scale for Young Adults with Paternal Substance Use Disorder in Pakistan. 巴基斯坦青少年父亲物质使用障碍的羞耻感量表构建与标准化。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-03-27 DOI: 10.1080/02791072.2025.2484378

Muhammad Nasar Iqbal, Shirmeen Ijaz, Zohaib Ahmed, Fatima Javed, Mujahid Iqbal

{"title":"Construction and Standardization of Perceived Shame Scale for Young Adults with Paternal Substance Use Disorder in Pakistan.","authors":"Muhammad Nasar Iqbal, Shirmeen Ijaz, Zohaib Ahmed, Fatima Javed, Mujahid Iqbal","doi":"10.1080/02791072.2025.2484378","DOIUrl":"https://doi.org/10.1080/02791072.2025.2484378","url":null,"abstract":"Young adults who struggle with paternal substance use disorder frequently experience elevated levels of shame, which are a result of both internalized feelings of inadequacy and societal stigma. This study aims to develop and validate a perceived shame scale with paternal substance use disorder. This study comprises two phases. Phase I involves the development of the perceived shame of paternal substance use disorder scale, and Phase II aims to validate this scale. This study employed a mixed-method research design and purposive sampling technique was used to collect data from 340 participants for exploratory factor analysis (EFA) and 300 participants for confirmatory factor analysis (CFA). Participants, aged 20-30 years (M = 25.12, SD = 3.05) were recruited. The results finalized twenty-two (22) items with four sub-scales after CFA i.e. psychological problems, interpersonal problems, existential problems, and social problems demonstrating excellent validity and reliability. In conclusion, the results provide a useful tool for future research and clinical interventions aimed at addressing paternal substance use disorder and related emotional difficulties, in addition to furthering our understanding of the internalized and societal causes of shame. The findings of this study have important ramifications for developing empathy, lowering stigma, and advancing efficient support networks for those dealing with this difficult problem.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Recreational Cannabis Legalization with Frequency of Using Cannabis for Sleep. 娱乐性大麻合法化与使用大麻睡眠频率的关系。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-03-27 DOI: 10.1080/02791072.2025.2484379

Zoë Panchal, Joseph T Sakai, Jarrod M Ellingson, Stephanie Zellers, Kenneth P Wright, Matt K McGue, Scott Vrieze, John K Hewitt, Robin P Corley, William Iacono, Christian J Hopfer, J Megan Ross

引用次数: 0

Cannabis and Cocaine, Heroin, or Methamphetamine Use and Factors Associated with Multiple Drug Use and Drug Treatment in a Nationally Representative Sample. 大麻和可卡因、海洛因或甲基苯丙胺的使用以及与多种药物使用和药物治疗相关的因素在全国代表性样本中。

IF 2.1 4区医学

Journal of psychoactive drugs Pub Date : 2025-03-27 DOI: 10.1080/02791072.2025.2484389

Ellen T Kurtzman, Christine Ramdin, Lewis S Nelson

{"title":"Cannabis and Cocaine, Heroin, or Methamphetamine Use and Factors Associated with Multiple Drug Use and Drug Treatment in a Nationally Representative Sample.","authors":"Ellen T Kurtzman, Christine Ramdin, Lewis S Nelson","doi":"10.1080/02791072.2025.2484389","DOIUrl":"https://doi.org/10.1080/02791072.2025.2484389","url":null,"abstract":"Cannabis is often used with other illicit drugs. Drawing from leading theories of polysubstance use, we used data from the 2009-2018 National Health and Nutrition Examination Survey to examine the prevalence of reported lifetime use of cannabis and cocaine, heroin, and/or methamphetamine among non-pregnant respondents ages 18-59 years. After identifying the subpopulation that reported using multiple drugs, we used multivariate logistic regression analysis to identify their demographic characteristics and factors associated with drug treatment participation. Within our analytic sample (N = 16,946), 18.7% reported lifetime cannabis use and cocaine, heroin, or methamphetamine use; 1.4% reported using all four of these drugs in their lifetime. Among individuals who reported using multiple drugs, 21.3% reported drug treatment participation. Compared to respondents who had never been in drug treatment, those who had been had higher odds of being non-Hispanic Black (AOR = 2.0, 95% CI 1.5-2.8), being in fair/poor health (AOR = 1.5, 95% CI 1.1-1.9), and reporting more medical conditions (AOR = 1.2, 95% CI 1.1-1.4). Being female, Mexican American, married, and a non-citizen lowered the odds of drug treatment. Having more than a high-school education and having a household income of more than $100,000 also reduced the odds of drug treatment.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-13"},"PeriodicalIF":2.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0