Journal of psychoactive drugs最新文献

Reactivations Associated with the Use of 5-MeO-DMT Among Spanish-Speaking Individuals: Prevalence, Predictors, and Emotional Valence. 西班牙语个体中与5-MeO-DMT使用相关的再激活：患病率、预测因子和情绪效价。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-10-23 DOI: 10.1080/02791072.2025.2577305

A M Ortiz Bernal, C L Raison, R L Lancelotta, C Timmermann, N D Sepeda, A K Davis

{"title":"Reactivations Associated with the Use of 5-MeO-DMT Among Spanish-Speaking Individuals: Prevalence, Predictors, and Emotional Valence.","authors":"A M Ortiz Bernal, C L Raison, R L Lancelotta, C Timmermann, N D Sepeda, A K Davis","doi":"10.1080/02791072.2025.2577305","DOIUrl":"https://doi.org/10.1080/02791072.2025.2577305","url":null,"abstract":"5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic gaining interest as a potential mental health treatment. However, a poorly characterized phenomenon termed reactivation (similar to \"flashbacks\") is commonly reported with 5-MeO-DMT use and merits investigation. This study examined the prevalence, predictors, and emotional valence of reactivations among Spanish-speaking individuals. Specifically, we investigated whether gender, time planned ahead, intensity of acute effects, and the meaningfulness attributed to the experience predicted reactivation events. We also explored whether decreases in cognitive fusion were associated with reactivations, and whether these variables influenced the emotional valence of those experiences. A cross-sectional survey study was conducted with 90 respondents. Descriptive statistics and logistic regression analyses were employed to examine the aims. Sixty-nine percent of respondents reported reactivations, with 97% indicating the experience was positive or neutral. In the multivariable logistic regression model, longer time planned ahead and decreases in cognitive fusion significantly predicted reactivations. Challenging experiences were associated with a lower likelihood of reactivations being perceived as positive, while psychological insight was linked to a higher likelihood of positive perceptions. Reactivations among this sample appear to be common and predominately perceived as positive or neutral. Their association with cognitive fusion decreases suggests potential clinical relevance worth further investigation.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145355205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychedelic Use and Intimacy: A Systematic Review of Experimental and Naturalistic Research. 迷幻药的使用和亲密：实验和自然主义研究的系统回顾。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-10-21 DOI: 10.1080/02791072.2025.2577311

Anna Bradford, Ethan Freedman, Rachel E Dinero

{"title":"Psychedelic Use and Intimacy: A Systematic Review of Experimental and Naturalistic Research.","authors":"Anna Bradford, Ethan Freedman, Rachel E Dinero","doi":"10.1080/02791072.2025.2577311","DOIUrl":"https://doi.org/10.1080/02791072.2025.2577311","url":null,"abstract":"In recent years, the potential psychological benefits of psychedelic drugs have garnered increasing interest from academic and medical communities. We conducted a systematic review of literature examining the association between psychedelic drugs use and intimacy. The initial search yielded 5,902 studies, of which 19 met the inclusion criteria. Studies varied in methodology, including placebo-controlled experimental designs, quasi-experimental designs, and retrospective self-reports. Positive intimacy-related outcomes were reported in all nine laboratory setting studies, including relationship satisfaction, connectedness, emotional disclosure, empathy, and affiliation, as well as decreased social anxiety. Of the 10 studies that relied solely on retrospective self-report, six identified positive intimacy-related experiences including relationship quality, interconnection, empathy, and closeness. Four of these studies identified negative intimacy-related experiences, including disconnection, social anxiety, and relationship dissatisfaction and distrust. This systematic review demonstrates overwhelmingly positive effects of psychedelic drug use in research-controlled settings, but more research is needed to identify both the ideal settings for psychedelic drug use and the long-term impact of these drugs on intimacy.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometric Properties of the 5-Item Weiss Cocaine Craving Scale (WCCS) in an Italian Clinical Sample: A Study of Dimensionality, Internal Consistency, Predictive and Nomological Validity. 意大利临床样本中5项Weiss可卡因渴望量表（WCCS）的心理测量特征：维度、内部一致性、预测效度和法效度研究

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-10-15 DOI: 10.1080/02791072.2025.2570942

Giulia Carla Zaffaina, Luis J Gómez Pérez, Sonia Chindamo, Alberto Terraneo, Diego Cuppone, Claudio Imperatori, Luigi Gallimberti

{"title":"Psychometric Properties of the 5-Item Weiss Cocaine Craving Scale (WCCS) in an Italian Clinical Sample: A Study of Dimensionality, Internal Consistency, Predictive and Nomological Validity.","authors":"Giulia Carla Zaffaina, Luis J Gómez Pérez, Sonia Chindamo, Alberto Terraneo, Diego Cuppone, Claudio Imperatori, Luigi Gallimberti","doi":"10.1080/02791072.2025.2570942","DOIUrl":"https://doi.org/10.1080/02791072.2025.2570942","url":null,"abstract":"Craving is a core characteristic in Cocaine Use Disorder (CUD) associated to relapse and treatment adherence. The assessment of craving is challenging due to the complexities arising from the various theoretical perspectives. Valid and reliable measures of craving are crucial in research and clinical settings considering the length to minimize the burden of patients. The existing craving assessment tools available in Italy are limited, with most instruments validated for populations other than CUD. This study aimed to validate the Italian adaptation of the 5-item Weiss Cocaine Craving Questionnaire (WCCS), a brief measure of cocaine craving. The sample included 385 CUD patients (359 men; mean age: 37.77 ± 8.46) undergoing multidisciplinary treatment. The Italian WCCS demonstrated a unidimensional factor structure and good internal consistency (Cronbach's alpha and McDonald's omega = 0.86). Nomological validity was assessed through significant associations with the Symptom Checklist-90-Revised (SCL-90-R), particularly with dimensions related to obsessivity-compulsivity, anxiety, and depression. Predictive validity was supported by receiver operating characteristics (ROC) analyses, with specific cutoff points enhancing the scale's utility in classifying cocaine use patterns and predicting cocaine relapses. These findings indicate that the Italian WCCS is a reliable and practical tool for clinical and research settings.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tianeptine Products: Public Health Threat or Niche Substance use? 天奈肽产品：对公众健康的威胁还是对小众物质的使用？

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-10-13 DOI: 10.1080/02791072.2025.2570939

Kirsten E Smith, Katherine Hill, Cecilia L Bergeria, Justin C Strickland

{"title":"Tianeptine Products: Public Health Threat or Niche Substance use?","authors":"Kirsten E Smith, Katherine Hill, Cecilia L Bergeria, Justin C Strickland","doi":"10.1080/02791072.2025.2570939","DOIUrl":"10.1080/02791072.2025.2570939","url":null,"abstract":"Among adults who have used tianeptine, we aimed to determine demographic and substance-use patterns and gain insights into tianeptine doses, effects, and consumer conceptualizations. We also evaluated problematic use, quit attempts, and tianeptine-specific substance-use disorder (SUD). Between December 2023 and July 2024, an online survey was conducted. Participants were ≥18 years old and endorsed lifetime use of kratom, kava, tianeptine, and/or akuamma seed. Of the 369 respondents, 6.0% (n = 22) reported lifetime tianeptine use; they were 35.6 years old on average, White, and male (81.8%) and evinced diverse substance use. Mean age of tianeptine-use initiation age was 31.0. More within the tianeptine-use group believed they currently had any SUD (40.9% versus 20.2%, p = .0002), had ever been prescribed methadone/buprenorphine (27.3% versus 8.1%, p = .009), and were interested in recovery (72.7% versus 28.8%, p < .0001). Use motivations included euphoria, self-management of psychiatric symptoms, and drug substitution. Tianeptine-tolerance onset was considered rapid (59.1%), with one-third experiencing adverse effects. For past-year tianeptine SUD (n = 15), 13.3% of participants were mild, 53.3% were severe. Many tianeptine conceptualizations were unfavorable: \"habit-forming\" (68.2%), \"addictive\" (68.2%), \"problematic\" (59.1%); 86.3% believed overdose was possible. Tianeptine was used at low rates in this sample of adults who consumed gray-market supplements and included unfavorable perceptions.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Questions and Concerns About MDMA-Assisted Therapy (MDMA-AT) in Veterans with PTSD Symptoms. mdma辅助治疗（MDMA-AT）在退伍军人PTSD症状中的问题与关注

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-10-10 DOI: 10.1080/02791072.2025.2570938

Mitch Earleywine, Caitlin Holley, Henry MacConnel, Stacey Farmer

{"title":"Questions and Concerns About MDMA-Assisted Therapy (MDMA-AT) in Veterans with PTSD Symptoms.","authors":"Mitch Earleywine, Caitlin Holley, Henry MacConnel, Stacey Farmer","doi":"10.1080/02791072.2025.2570938","DOIUrl":"https://doi.org/10.1080/02791072.2025.2570938","url":null,"abstract":"MDMA-assisted therapy (MDMA-AT) for post-traumatic stress disorder (PTSD) shows promise, but attitudes and beliefs about this treatment, especially in symptomatic veterans, remain poorly understood. We sought to explore relevant attitudes in veterans receiving healthcare from Veterans Affairs as a step toward designing relevant surveys or psychoeducation materials for future work. We employed a story completion paradigm designed to sidestep aspects of self-report bias. Participants (N = 30) crafted narratives about an anonymous veteran with PTSD contemplating MDMA-AT. Coders rated transcripts, revealing recurring themes. At least one third of the sample mentioned shortcomings of available treatments, curiosity about its rationale, hope, and concerns about side effects, subjective effects, and the possibility of addictive potential. Despite widespread news coverage of the topics, allusions to therapist abuse, microdosing, and the role of sitters were relatively rare. At least 10% of the sample mentioned clear misunderstandings about the molecule, the treatment, or its implications. These data provide directions for the development of standard surveys of psychedelic-assisted treatments, which would help address these attitudes in larger samples. They can also inform psychoeducation materials that might help increase public awareness about this intervention, especially for veterans with symptoms.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Epidemiology of Recreational Use and Availability of DOC and DOI in the United States. 娱乐性使用的流行病学和DOC和DOI在美国的可用性。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-10-09 DOI: 10.1080/02791072.2025.2570937

Joseph J Palamar, Nicole D Fitzgerald

{"title":"The Epidemiology of Recreational Use and Availability of DOC and DOI in the United States.","authors":"Joseph J Palamar, Nicole D Fitzgerald","doi":"10.1080/02791072.2025.2570937","DOIUrl":"10.1080/02791072.2025.2570937","url":null,"abstract":"The U.S. Drug Enforcement Administration (DEA) proposed a rule in which they intend to place the psychedelic phenethylamines 2,5-dimethoxy-4-chloroamphetamine (DOC) and 2,5-dimethoxy-4-iodoamphetamine (DOI) into Schedule I of the Controlled Substances Act. We investigated the epidemiology of use and availability of these substances. We investigated national trends in seizures of these compounds (which indicate availability) using DEA National Forensic Laboratory Information System (NFLIS) and High Intensity Drug Trafficking Areas (HIDTA) data. We also examined the prevalence of self-reported use on the National Survey of Drug Use and Health (NSDUH), a nationally representative sample of noninstitutionalized individuals aged ≥12 in the United States. The scientific literature was also systematically searched for reports of poisonings linked to use. Between 2005 and 2024, NFLIS received 795 submissions of drugs testing positive for DOC, with a peak of 152 in 2012. There was then a decrease through 2024, with only two submissions containing DOC in 2023-2024. Forty submissions contained DOI, with no submissions testing positive in 2019-2024. Three DOC seizures were recorded by HIDTA in 2017-2021, with none in 2022-2024. HIDTA had no recorded seizures of DOI. Between 2005 and 2023, there were 37 and 10 type-in mentions of lifetime DOC and DOI use, respectively, in NSDUH responses, suggesting a lifetime prevalence of < 0.01% among the noninstitutionalized U.S. population. We located three reports of poisonings linked to DOC use (in 2008-2024) and none linked to DOI use. Availability, recreational use, and poisoning related to the use of DOC and especially DOI appear to be rare.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining Volunteer Bias in Psychedelic Research. 在迷幻药研究中检验志愿者偏见。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-10-08 DOI: 10.1080/02791072.2025.2570936

Samantha G Gomez, Fiona Low, Mitch Earleywine

{"title":"Examining Volunteer Bias in Psychedelic Research.","authors":"Samantha G Gomez, Fiona Low, Mitch Earleywine","doi":"10.1080/02791072.2025.2570936","DOIUrl":"https://doi.org/10.1080/02791072.2025.2570936","url":null,"abstract":"Since its resurgence, psychedelic research has garnered considerable attention, especially in mental health. Preliminary findings have indicated positive results regarding psychedelic-assisted psychotherapy. Despite promising findings, various researchers have voiced concerns regarding psychedelic research and its potential for volunteer bias. Participants willing to participate in clinical trials, for example, might differ dramatically from the general population. The current study attempts to identify the potential volunteer bias that might contribute to current results. Participants recruited on MTurk (N = 702) provided demographic information as well as self-reported psychedelic use. We used binary logistic regressions to assess whether demographic and reported psychedelic use variables predicted willingness to participate in six hypothetical psychedelic studies. Results indicated that psychedelic use increased willingness to participate in a single unpaid survey, multiple unpaid surveys presented longitudinally, as well as an unpaid administration study. No demographic variables predicted volunteering consistently. Differences between paid and unpaid participation suggested that compensation might help reach broader samples. Given the implications related to volunteer bias and impeded generalizability, these findings indicate a need for further research to fully address the concern of volunteer bias in psychedelic research. Reaching those with less psychedelic experience will likely be imperative to investigations of clinical implications.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Policy to Perception: Do Public Views on UK Drug Policy Shape Attitudes Toward Psychedelics? 从政策到认知：公众对英国毒品政策的看法会影响对迷幻药的态度吗？

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-09-11 DOI: 10.1080/02791072.2025.2558579

Katie Dickson, Daniel R Stubbings, Megan Hurst, Joseph L Davies

{"title":"From Policy to Perception: Do Public Views on UK Drug Policy Shape Attitudes Toward Psychedelics?","authors":"Katie Dickson, Daniel R Stubbings, Megan Hurst, Joseph L Davies","doi":"10.1080/02791072.2025.2558579","DOIUrl":"10.1080/02791072.2025.2558579","url":null,"abstract":"Psychedelic substances have gained attention for their therapeutic potential, yet they remain illegal in the UK. This study aimed to explore whether public attitudes toward UK drug policy predicted attitudes toward psychedelics, in terms of their legal status, the effects of psychedelics on individuals and society, the risks associated with psychedelic use, and personal openness toward psychedelic experiences and their potential positive effects. A cross-sectional survey was conducted with 250 participants aged 18-86 (M = 38.1, SD = 15.8), using the APQ and sociodemographic measures. Multiple regression analyses revealed that viewing drug use as a health issue, rather than a criminal issue, was a significant predictor of support for psychedelic legalization and lower perceived risk. Additionally, gender, religious affiliation, political leaning, and prior drug use significantly influenced attitudes toward psychedelics. Women and religious individuals tended to view psychedelics as more harmful, while left-leaning and non-religious participants were more supportive of their therapeutic use. Participants with prior drug use experience were more open to psychedelics. These findings suggest that public attitudes may be influenced by broader drug policy perceptions and that shifts in policy framing toward health-based approaches could foster greater support for psychedelic reform. Further research should explore these associations longitudinally.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortisol/DHEA-S Ratio Normalization by Buprenorphine: Associations with Stress, Coping, and Social Support in Youth with Opioid Use Disorder. 丁丙诺啡使皮质醇/DHEA-S比值正常化：与阿片类药物使用障碍青少年的压力、应对和社会支持有关。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-09-02 DOI: 10.1080/02791072.2025.2550288

Manmeet Kaur Brar, Raka Jain, Roshan Bhad, Anju Dhawan, Rahul Raghav

{"title":"Cortisol/DHEA-S Ratio Normalization by Buprenorphine: Associations with Stress, Coping, and Social Support in Youth with Opioid Use Disorder.","authors":"Manmeet Kaur Brar, Raka Jain, Roshan Bhad, Anju Dhawan, Rahul Raghav","doi":"10.1080/02791072.2025.2550288","DOIUrl":"10.1080/02791072.2025.2550288","url":null,"abstract":"Opioid use disrupts the hypothalamic-pituitary-adrenal (HPA) axis, altering stress responses depending on the stage of use. A higher cortisol/DHEA-S ratio may indicate relapse risk in substance use disorders. This study aimed to explore differences in serum cortisol/DHEA-S ratio and its association with proximal and perceived stress, social support, and coping strategies in opioid-dependent youth. In this study, we assessed 51 males aged 15-24 with opioid (heroin) use disorder from an Indian treatment center, categorized into three groups: recently admitted patients with opioid use, buprenorphine-maintained patients, and healthy controls (n = 17 each). Serum cortisol and DHEA-S levels were analyzed using ELISA. We found significant differences in cortisol (p < .001), DHEA-S (p < .001), and cortisol/DHEA-S ratio (p < .001) across groups. Recently admitted patients with opioid use had elevated cortisol/DHEA-S ratios (0.37), whereas buprenorphine maintenance with active coping strategies showed reduced ratios (0.22), indicating potential normalization of HPA axis function. Cortisol levels correlated positively with past-year stress in recent users, whereas the cortisol/DHEA-S ratio correlated negatively with social support. These findings suggest that buprenorphine maintenance, combined with effective coping and social support, may help normalize HPA axis imbalance, potentially reducing relapse risk in opioid-dependent youth. Further research is needed to confirm these findings and their implications for treatment strategies.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significant Psychedelic Experiences Evaluated for Mystical Characteristics Associated with Cannabis Use Reduction and Psychological Flexibility Improvement: A Naturalistic Cross-Sectional Retrospective Survey. 重要迷幻体验的神秘特征评估与减少使用大麻和提高心理灵活性有关：一项自然主义横断面回顾性调查。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2025-09-01 Epub Date: 2024-07-03 DOI: 10.1080/02791072.2024.2375720

B Romeo, E Kervadec, B Fauvel, L Strika-Bruneau, A Amirouche, V Verroust, P Piolino, A Benyamina

{"title":"Significant Psychedelic Experiences Evaluated for Mystical Characteristics Associated with Cannabis Use Reduction and Psychological Flexibility Improvement: A Naturalistic Cross-Sectional Retrospective Survey.","authors":"B Romeo, E Kervadec, B Fauvel, L Strika-Bruneau, A Amirouche, V Verroust, P Piolino, A Benyamina","doi":"10.1080/02791072.2024.2375720","DOIUrl":"10.1080/02791072.2024.2375720","url":null,"abstract":"Treating cannabis use disorder remains a significant challenge in the field of addiction medicine. Some recent studies point to psychedelic-assisted psychotherapy as a potential treatment option for substance use disorders. The objective of this study was therefore to explore the impact of naturalistic psychedelic experiences on cannabis use and psychological flexibility. An online retrospective survey was carried out on 152 cannabis users who also reported a significant experience induced by psychedelics in the past. Following a psychedelic experience, there was a significant and sustained reduction of average CUDIT score (p < .001), frequency of cannabis use (p < .001), and acute duration of daily intoxication (p < .001). Cannabis use reduction during the first month post-experience was significantly associated with the intensity of the mystical experience (p = .01). Participants reported a concomitant increased lasting improvement of psychological flexibility following the experience (p < .001), which was correlated to the intensity of the mystical experience during the first month post-experience (p = .04). This study demonstrates that naturalistic psychedelic experiences may be followed by a decrease in cannabis use. Positive health outcomes appear potentially connected to the intensity of the mystical experience, as well as an improvement in psychological flexibility.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"374-385"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0