Journal of psychiatric research最新文献

{"title":"Self-regulation in adults with intermittent explosive disorder and a history of suicide attempts","authors":"Matthew A. Timmins ,&nbsp;So Yu Cicy Ng ,&nbsp;Emil F. Coccaro","doi":"10.1016/j.jpsychires.2025.01.058","DOIUrl":"10.1016/j.jpsychires.2025.01.058","url":null,"abstract":"<div><div>Both suicide attempts and aggression aim to cause harm and are associated with numerous personal and societal consequences but differ on intended targets. Aggression towards others is associated with increased risk of suicidal behavior. Research has demonstrated commonalities with impulsiveness and affect regulation for both. This study's purpose was to compare self-regulation between those meeting criteria for a psychiatric condition characterized by unplanned aggression (intermittent explosive disorder [IED]), a lifetime history of a suicide attempt (SA), and those with both (IED + SA), as well as compared to participants meeting criteria for non-aggressive psychopathology (PC) or no psychiatric disorder (HC). Adult community participants (<em>n</em> = 735) completed diagnostic assessments and self-report measures on suicidal behaviors, aggression, trait anger, impulsivity, and affect regulation as part of a larger aggression research program. Pairwise comparisons found IED + SA was associated with the highest scores on all outcome variables except compared to IED on anger. IED had higher aggression and anger scores than SA but did not differ on general impulsivity and affect regulation scores. PC did not differ from SA on anger or from IED and SA on affect regulation; PC scored lower on aggression and anger than IED + SA and IED. HC scored lowest on all variables. Such results imply IED with past suicidal behavior may be associated with heightened self-regulation difficulties overall compared to IED alone and non-aggressive psychopathology. Future research may build upon this by further recruiting for both unplanned aggression and suicidal behavior, as well as including comparisons with other impulsivity-related diagnoses.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 530-536"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143138303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguished multimodal imaging features affected by COVID-19 in major depressive disorder patients","authors":"Taipeng Sun ,&nbsp;Chenguang Jiang ,&nbsp;Yubo Zhang ,&nbsp;Yueying Li ,&nbsp;Gang Chen ,&nbsp;Yue Zhou ,&nbsp;Wei Xu ,&nbsp;Linlin You ,&nbsp;Youyong Kong ,&nbsp;Wenhao Jiang ,&nbsp;Yonggui Yuan","doi":"10.1016/j.jpsychires.2025.01.053","DOIUrl":"10.1016/j.jpsychires.2025.01.053","url":null,"abstract":"<div><h3>Objectives</h3><div>Growing attention has been directed toward the structural and functional alterations among individuals infected with COVID-19. However, data on its impact on patients with Major Depressive Disorder (MDD) remain limited.</div></div><div><h3>Methods</h3><div>This study investigates the effects of COVID-19 on patients with MDD and healthy controls (HCs) using MRI scans. Participants were categorized into four groups: MDD patients before (n = 165) and after COVID-19 infection (n = 70), HCs before (n = 108) and after COVID-19 infection (n = 57). All participants underwent T1-weighted imaging, diffusion tensor imaging (DTI), and resting-state functional MRI from January 2022 to August 2023.</div></div><div><h3>Results</h3><div>Structural alterations associated with COVID-19 were predominantly observed in the white matter (WM) rather than the gray matter (GM), with specific involvement noted in the superior longitudinal fasciculus tract, Forceps minor tract, and cingulum-cingulate gyrus tract among patients with MDD. Functional changes were spread from GM to WM. The bilateral supplementary motor area, the left angular gyrus, the left subcortical regions (amygdala and parahippocampal gyrus), and various WM tracts showed significant infection-related changes across groups.</div></div><div><h3>Conclusion</h3><div>COVID-19 infection induces significant microstructural damage of WM in healthy individuals and exacerbates white matter microstructural injury of MDD. These findings suggest that WM might be more susceptible to COVID-19 effects than GM in both MDD patients and HCs.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 1-9"},"PeriodicalIF":3.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of depression, anxiety, and stress symptoms in different trimesters of pregnancy: A meta-analysis and meta-regression.","authors":"Halimatusaadiyah Abdul Aziz, Huda Dianah Binte Yahya, Wen Wei Ang, Ying Lau","doi":"10.1016/j.jpsychires.2024.11.070","DOIUrl":"10.1016/j.jpsychires.2024.11.070","url":null,"abstract":"<p><p>The global prevalence of psychological problems in different trimesters is unclear due to methodological constraints in previous reviews. A precise estimate would be a key first step in raising awareness and allocating resources. This review aims to (1) calculate the global prevalence of depression, anxiety, and stress symptoms during different trimesters and (2) determine the factors influencing their prevalence estimates. A comprehensive search across eight databases was conducted. The meta packages in R software were used to perform meta-analysis, subgroup analysis, and meta-regression analysis. The Newcastle Ottawa Scale was used to assess the study quality, while the Grading of Recommendations, Assessment, Development, and Evaluation method was utilized to assess the certainty of the evidence. A total of 88 studies with 61,719 participants across 48 countries were included. The prevalences of depression, anxiety, and stress symptoms during all trimesters were 27% (95% CI: 23-31), 37% (95% CI: 31-42), and 26% (95% CI: 9-49), respectively. The second trimester had the highest prevalence of depression (30%) and anxiety (28%) symptoms, whereas the third trimester had the highest prevalence of stress symptoms (52%). A series of subgroup and meta-regression analyses revealed that regions, economic levels of the country, setting, the COVID-19 pandemic, and quality of study were significant factors. Most studies were high quality, but the certainty of the evidence was very low. Findings can contribute as evidence to raising awareness about specific psychological problems during different trimesters. Implementing effective policies and launching targeted interventions can help minimize the prevalence.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"528-546"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the number of acute episodes and increased cardiac left ventricular mass index in patients diagnosed with schizophrenia.","authors":"Pao-Huan Chen, Shang-Ying Tsai, Shuo-Ju Chiang, Cheng-Yi Hsiao, Yen-Kuang Lin, Kuo-Hsuan Chung","doi":"10.1016/j.jpsychires.2024.12.023","DOIUrl":"10.1016/j.jpsychires.2024.12.023","url":null,"abstract":"<p><p>Patients with schizophrenia have a high risk of cardiovascular death. Increased cardiac left ventricular (LV) mass has been reported to be associated with heart failure and cardiac mortality. However, few studies have used echocardiographic imaging to evaluate the associations between cardiac LV mass and the clinical characteristics of schizophrenia. We recruited 121 adults to undergo standard and two-dimensional speckle-tracking echocardiography. Cardiac LV mass was determined using the Devereux formula and indexed with reference to the body surface area to obtain the cardiac LV mass index (LVMI). Clinical and demographic data were obtained through interviews and chart review. The results showed that relative to the mentally healthy controls (n = 55), individuals with schizophrenia (n = 66) had significantly higher mean values of cardiac LVMI as well as lower mitral valve E/A ratio, LV ejection fraction, and LV global longitudinal strain. Among the individuals with schizophrenia, cardiac LVMI was positively correlated with the number of acute episodes, and this association remained significant after adjustment for age, age at onset, and body mass index. On the contrary, there were no significant associations between cardiac LVMI and traditional cardiovascular risk factors. Taken together, this study suggests that the burden of psychotic symptoms may contribute to the increased risk of cardiac hypertrophy in individuals with schizophrenia independent of traditional cardiovascular risk factors. Because cardiac hypertrophy is among the major risk factors of heart failure and cardiac mortality, future research must investigate the mechanisms underlying the association between psychosis and increased cardiac LV mass.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"681-688"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor structure, reliability and validity of an Indian Scale for Assessment of Nomophobia (ISAN) among college students: A multicentre Indian study.","authors":"Rajeev Ranjan, Yatan Pal Singh Balhara, Biswa Ranjan Mishra, Shamshad Ahmad, Siddharth Sarkar, Ayushi Bharti, Sahadeb Panigrahi, Muskan Sinha, Akanksha Jayant Rajguru, Pankaj Kumar, Debadatta Mohapatra, Arpit Parmar, Meha Jain","doi":"10.1016/j.jpsychires.2024.12.036","DOIUrl":"10.1016/j.jpsychires.2024.12.036","url":null,"abstract":"<p><strong>Background: </strong>The current severity assessment measures for nomophobia have issues related to clinical applicability, which makes them difficult to be consistently applied in the Indian context. We aimed to develop a valid and reliable instrument for the assessment of severity of Nomophobia.</p><p><strong>Methods: </strong>This study was a two-phase, exploratory sequential mixed method design conducted across three centres in India. The development of the questionnaire included identification of the domains and items, inputs from experts and refining the questionnaire. EFA was carried out to check the internal consistency among items. CFA was carried out to test the factor structure of ISAN. Concurrent validity with NMP-Q was ascertained. Convergent and discriminant validity were tested using bivariate correlation analysis.</p><p><strong>Results: </strong>The qualitative findings from the initial exploration were developed into 27-item ISAN reviewed by experts for content validity. EFA showed that the questionnaire has good internal consistency (Cronbach's alpha reliability coefficient = 0.934) with a five-factor pattern matrix. CFA explained five-factor structure (Digital compulsion, Digital Intensement, Digital Obsession, Digital Detachment Distress and Digital Engagement) was deemed to be the most tenable comprising of 21 items. ISAN fits good on all indices (CMIN/df = 2.44, CFI = 0.93, RMSEA = 0.05, TLI = 0.92, IFI = 0.93) for the five-factor structure. Concurrent validity with NMP-Q was good (r = 0.695). Good to moderate associations were noted for the convergent (r = 0.985) and discriminant validity (r = -0.560) respectively.</p><p><strong>Conclusion: </strong>ISAN (Indian Scale for Assessment of Nomophobia) is an accurate and reliable instrument that can measure nomophobia in the Indian youth population.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"599-606"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of mindfulness-based stress reduction on neuropeptide Y plasma levels in stressed individuals.","authors":"Helle Degnbol Østergaard, Karen Johanne Pallesen, Marit Nyholm Nielsen, Lone Fjorback, Lise Juul, Michael Winterdahl","doi":"10.1016/j.jpsychires.2024.12.011","DOIUrl":"10.1016/j.jpsychires.2024.12.011","url":null,"abstract":"<p><strong>Background: </strong>Clinical studies have suggested that dysregulation of the neuropeptide Y (NPY) system may play a role in psychiatric disorders, including chronic stress. Meanwhile, Mindfulness Based Stress Reduction (MBSR) has shown promise for stress-related maladies. However, no studies have explored whether MBSR can change plasma NPY concentration in stressed individuals.</p><p><strong>Method: </strong>Individuals with symptoms of chronic stress were randomly assigned to eight weeks of either MBSR (n = 15), a locally-developed stress reduction intervention (LSR) (n = 15) or a wait-list control group (n = 20). Blood samples were collected at baseline and at a twelve-week follow-up to determine the effects of MBSR or LSR compared to the wait-list control group on NPY levels.</p><p><strong>Results: </strong>The MBSR group had increased plasma NPY levels after the program compared to the waitlist control group, whereas the LSR group was not statistically different from the other groups.</p><p><strong>Conclusion: </strong>This pilot study provides evidence of the feasibility of MBSR to alter plasma NPY.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"400-404"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between social media use and positive mental health among adolescents: Findings from the Canadian Health Behaviour in School-aged Children Study.","authors":"Zahra M Clayborne, Suzy L Wong, Karen C Roberts, Stephanie A Prince, Geneviève Gariépy, Gary S Goldfield, Ian Janssen, Justin J Lang","doi":"10.1016/j.jpsychires.2024.11.071","DOIUrl":"10.1016/j.jpsychires.2024.11.071","url":null,"abstract":"<p><p>Social media use (SMU) has rapidly increased among children and adolescents in the past decade, and has been linked with poorer mental health. However, moderate SMU can facilitate connectedness among peers, which may have positive impacts for well-being - these associations are underexplored. This study examined the associations between SMU and several indicators of PMH in a nationally representative sample of 13,113 adolescents in grades 6 to 10 from the 2017/2018 cycle of the Canadian Health Behavior in School-aged Children (HBSC) study. SMU was measured using a four-level composite of intensity (non-active, active, intense) and problematic SMU (addictive-like symptoms, regardless of intensity). Four dichotomous indicators of PMH were examined: self-efficacy, self-confidence, life satisfaction, and psychological well-being. Covariates included grade, gender, cultural/racial background, and socioeconomic status. Unadjusted and adjusted mixed effects logistic regression models accounting for school-level clustering were run, with separate models for each PMH indicator and active SMU set as the referent. When compared to active SMU, problematic SMU was associated with lower levels of all PMH indicators, and intense SMU was associated with lower life satisfaction. In gender-stratified models, intense SMU was associated with lower life satisfaction among girls. In grade-stratified models, non-active SMU was associated with lower self-confidence for adolescents in grades 9 and 10. In all, problematic SMU is generally associated with lower odds of reporting high PMH. Longitudinal research is required to ascertain directionality of these findings, and to examine how these associations may have changed as a result of the COVID-19 pandemic.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"333-339"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trial of computerized working memory training for Veterans with PTSD.","authors":"J Bomyea, M M Caudle, A L Bartolovich, A N Simmons, A J Jak, S Golshan","doi":"10.1016/j.jpsychires.2024.11.072","DOIUrl":"10.1016/j.jpsychires.2024.11.072","url":null,"abstract":"<p><p>Posttraumatic stress disorder (PTSD) is a common psychiatric condition among Veterans that is associated with deficits across a range of neuropsychological domains including working memory. While gold-standard psychosocial treatments are highly effective, there still remains a high rate of individuals who do not engage with or fully benefit from them. Cognitive training targeting specific working memory deficits in PTSD presents an alternative treatment approach that has shown promise for reducing re-experiencing symptoms. The current study evaluated a 16-session working memory training (WMT) program in Veterans with PTSD, focusing on two levels of interference control training. Feasibility, acceptability, and clinical efficacy were assessed. Results indicated that the intervention was generally feasible and acceptable to Veterans and revealed similar effects between groups in the intent to treat analyses; however, the high interference control training group yielded greater re-experiencing symptom reductions than the low interference control training group among individuals who were protocol adherent (Hedges' g = 0.57). There were significant reductions in overall PTSD severity across groups. Results are broadly consistent with theoretical models and prior clinical trials linking working memory task improvement to re-experiencing symptom reductions. These results point to the potential for working memory training to be a viable intervention for PTSD in Veterans, though further research is necessary for validation and exploration of broader clinical outcomes.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"350-357"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The phenomenon of despair in patients with depression.","authors":"Paraskevi Mavrogiorgou, Leonard Fischer, Martin Bürgy, Georg Juckel","doi":"10.1016/j.jpsychires.2024.12.021","DOIUrl":"10.1016/j.jpsychires.2024.12.021","url":null,"abstract":"<p><strong>Objective: </strong>Despair is a common feature of depressive disorders. The aim was to characterize the cognitive-affective phenomenon of despair in patients with a depressive disorder by means of the newly developed Bochum-Stuttgart Despair Scale (BSVS) in comparison to the Northwestern Ego Integrity Scale (NEIS).</p><p><strong>Methods: </strong>A total of 33 depressed patients and 33 age- and gender-matched healthy subjects were studied with respect to despair but also with respect to biographical and psychometric characteristics such as depressiveness, hopelessness, fear of finality and suicidality.</p><p><strong>Results: </strong>Depressed patients were significantly more despondent than healthy subjects in both BSVS-Cognitive and BSVS-Emotional, and this was also reflected in the NEIS-Despair subscale.</p><p><strong>Conclusion: </strong>Despair of depressed patients is probably constituted by different factors than the despair of mentally healthy individuals.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"648-652"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing autogenous and reactive obsessions using theta and beta oscillations under inhibitory demands.","authors":"Zachary T Gemelli, Maryam Ayazi, Han-Joo Lee","doi":"10.1016/j.jpsychires.2024.12.024","DOIUrl":"10.1016/j.jpsychires.2024.12.024","url":null,"abstract":"<p><p>Obsessive-Compulsive Disorder (OCD) is a heterogenous mental health condition that causes significant impairment and is often associated with poor treatment outcomes. The aim of the current study was to examine the association between electroencephalographic (EEG) oscillatory power during inhibitory task performance and obsessive-compulsive symptoms (OCS). OCS was assessed using the well-established the Autogenous-Reactive Obsession (AO-RO) model as the main framework to address its heterogeneous clinical manifestations. The severity of AO and RO, as primary outcome measures, was indexed using the Revised Obsessive Intrusion Inventory (ROII). Cognitive- and behavioral inhibition (CI; BI) tasks were administered while EEG data were recorded from an analogue sample of 63 undergraduate students with OCS assessed along a dimensional spectrum. Oscillatory power was computed from frontal-central electrodes Fz and Cz for theta and beta frequency bands, using event-related spectral perturbations (ERSPs), which were entered into two hierarchical linear regression models to predict the severity of AO and RO, respectively, while controlling for covariates (i.e., sex, age, ethnicity, anxiety, depression, worry, and behavioral task performance). Theta power during CI (Theta-CI) was the only significant EEG predictor of AO severity, whereas beta power during BI (Beta-BI) was the only significant EEG predictor of RO severity. These results suggest that AO severity is primarily associated with an overactive neural correlate of cognitive control, whereas RO severity is primarily associated with an overactive neural correlate of behavioral cancellation. These results agree with previous literature suggesting overactive band power representing the dysfunction within OCD. Theta-CI and Beta-BI may serve as potential biomarkers differentially associated with AO and RO among undiagnosed individuals displaying varying levels of OCS, which warrants further investigation.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"579-585"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}