Journal of psychiatric research最新文献

{"title":"The relationship between sleep and circadian patterns with risk for suicide in bipolar disorder varies by subtype","authors":"Jennifer R. Goldschmied ,&nbsp;Emma Palermo ,&nbsp;Anastasia Yocum ,&nbsp;Melvin McInnis ,&nbsp;Philip Gehrman","doi":"10.1016/j.jpsychires.2024.11.030","DOIUrl":"10.1016/j.jpsychires.2024.11.030","url":null,"abstract":"<div><h3>Introduction</h3><div>Sleep and circadian disturbances play a crucial role in psychiatric disorders, especially mood disorders such as bipolar disorder. This study investigated the predictive value of self-reported sleep and circadian factors for suicide risk in individuals with bipolar type I and bipolar type II disorder.</div></div><div><h3>Methods</h3><div>Data were collected from the Heinz C. Prechter Longitudinal Study of Bipolar Disorder. Suicide risk was evaluated using the Columbia Suicide-Severity Rating Scale, while the sleep and circadian factors were extracted from the Pittsburgh Sleep Quality Index, Hamilton Depression Rating Scale, and Munich Chronotype Questionnaire.</div></div><div><h3>Results</h3><div>A stepwise selection procedure identified significant predictors for each group. Results showed that suicide risk in individuals with bipolar disorder type I was associated with insomnia, whereas risk in bipolar disorder type II was associated with evening chronotype.</div></div><div><h3>Conclusion</h3><div>These findings indicate that specific sleep and circadian disturbance variables confer unique risk for suicide in the subtypes of bipolar disorder. This highlights the importance of conducting a thorough sleep and circadian assessment in clinical practice and emphasizes the need for clinical trials investigating the impact of sleep and circadian interventions on mitigating suicide risk in individuals with bipolar disorder.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 23-28"},"PeriodicalIF":3.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of depression and disability in the association between widowhood and cognitive function among elderly Chinese individuals","authors":"Chuanlei Zheng ,&nbsp;Yanhong Liu ,&nbsp;Sisi Xie ,&nbsp;Shaobo Zeng ,&nbsp;Qingfeng Wu","doi":"10.1016/j.jpsychires.2024.11.026","DOIUrl":"10.1016/j.jpsychires.2024.11.026","url":null,"abstract":"<div><h3>Objective</h3><div>The incidence of mild cognitive impairment among the elderly in China was increasing. Widowhood, depression, and disability were significant factors that impacted cognitive function. Yet, there was currently no research, both domestically and internationally, that comprehensively examines all these factors together. Therefore, in order to achieve successful aging, the objective of this study is to investigate the impact and pathway of depression and disability on the association between widowhood and cognitive function in the elderly population of China, with the aim of establishing a robust foundation for developing evidence-based strategies to prevent and manage cognitive impairment among older adults in China.</div></div><div><h3>Methods</h3><div>The 2018 Chinese Longitudinal Healthy Longevity Survey data was utilized to assess cognitive function, depression level, and disability status using the Mini-Mental State Examination, The Center for Epidemiological Studies Depression-10 scale, and the Katz scale. The mediating role of depression and disability in the association widowhood and cognitive function were tested by the bruceR package in R Studio.</div></div><div><h3>Results</h3><div>A total of 7973 elderly individuals aged over 65 were included in the study, with nearly 50% being widowed. Widowhood was identified as a significant risk factor for cognitive impairment in the elderly population. The results from the analysis of mediating effects indicated that both depression and disability independently mediated this relationship, while also contributing to a chain-mediated effect on the association between widowhood and cognitive function in the population.</div></div><div><h3>Conclusion</h3><div>We recommend that greater attention be dedicated to this population, and measures be implemented to enhance their mental well-being and disability management, thereby improving cognitive function.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 1-6"},"PeriodicalIF":3.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-attendance in randomized remote mental health clinical trial during the COVID-19 pandemic","authors":"Dayane Santos Martins ,&nbsp;Natan Pereira Gosmann ,&nbsp;Carolina Blaya Dreher ,&nbsp;Giovanni Abrahão Salum ,&nbsp;Gisele Gus Manfro","doi":"10.1016/j.jpsychires.2024.11.024","DOIUrl":"10.1016/j.jpsychires.2024.11.024","url":null,"abstract":"<div><div>During the COVID-19 pandemic, a significant increase in psychiatric symptoms was found among essential service professionals (professionals or interns from the health and educational sector) who were exposed to high-risk contamination areas. These symptoms impair functionality, impacting quality of life, work, autonomy, and relationships. Recent data show that brief interventions are effective; however, between 20 and 30% of those individuals often do not attend their scheduled appointments. This study aimed to identify variables related to non-attendance for remote telepsychotherapy among participants with COVID-19-related emotional distress compared to those who initiated treatment. We included 2097 essential service professionals with PROMIS (Patient-Reported Outcomes Measurement Information System) T-scores ≥70 for anxiety, depression, or irritability who scheduled a remote mental health appointment. Participants completed clinical and sociodemographic data, mental health risk and protective factors, and PROMIS subscales. We conducted a binary logistic regression, using attendance vs. non-attendance as the dependent variable and these demographic and clinical characteristics as independent variables. Of the 2097 participants, 230 (11%) did not attend the first session despite three rescheduling attempts. Non-attendance was associated with the presence of irritability and seeking treatment during the second COVID-19 wave. In contrast, anxious symptoms, older age, and coping mechanisms that typically include intellectual and reading activities were associated with attendance. Our findings shed light on non-attendance patterns in mental health services, revealing that personal characteristics and environmental factors significantly contribute to missed appointments. Understanding these dynamics can improve patient engagement and adherence to mental health treatments, particularly in the context of telepsychotherapy during the COVID-19 pandemic.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"180 ","pages":"Pages 506-510"},"PeriodicalIF":3.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacologic prophylaxis of postoperative delirium in elderly patients: A network meta-analysis of randomized controlled trials","authors":"Ting-Hui Liu ,&nbsp;Yen-Ting Lin ,&nbsp;Jheng-Yan Wu ,&nbsp;Po-Yu Huang ,&nbsp;Wen-Wen Tsai ,&nbsp;Chih-Cheng Lai ,&nbsp;Pei-Hsin Kao ,&nbsp;Kuan-Pin Su","doi":"10.1016/j.jpsychires.2024.11.002","DOIUrl":"10.1016/j.jpsychires.2024.11.002","url":null,"abstract":"<div><h3>Background</h3><div>The high incidence and mortality rates of postoperative delirium (POD) among elderly patients highlights the pressing need for tailored prophylactic strategies. Despite various pharmacologic prophylactic strategies have been reported effective, their overall benefit and safety remain unclear in the geriatric population. Our network meta-analysis (NMA) aimed to systematically evaluate and rank the effectiveness of various pharmacological interventions in preventing POD in elderly patients.</div></div><div><h3>Methods</h3><div>We conducted an extensive search of PubMed, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, and Google Scholar for randomized controlled trials (RCTs) published up to August 1, 2023. We included RCTs examining pharmacological prophylactic effects of POD in elderly patients. To extract data in alignment with predefined areas of interest, we employed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. The primary outcome was the incidence of POD. For secondary outcomes, we evaluated tolerability through all-cause discontinuation or drop-out rates, as well as all-cause mortality.</div></div><div><h3>Results</h3><div>Our analysis encompassed a total of 44 RCTs involving 11,178 patients. Out of these, 26 RCTs involved comparisons with placebo only. For delirium prevention, the treatment groups receiving atypical antipsychotics (odds ratio (OR) of 0.27 and 95% confidence interval (CI) of 0.12–0.58), haloperidol (OR of 0.42; 95% CI of 0.25–0.71), dexmedetomidine (OR of 0.51 and 95% CI of 0.37–0.71 and melatonergic agents (MMA) (OR of 0.57 and 95% CI of 0.33–0.98) had significantly lower rates of delirium compared to the placebo group. Notably, the atypical antipsychotics ranked as the most effective treatment. For tolerability, no statistically differences in rates of dropout discontinuation and all-cause mortality among groups allocated to the placebo or individual pharmacological treatments.</div></div><div><h3>Conclusions</h3><div>Based on indirect evidence, our network meta-analysis identified atypical antipsychotics, dexmedetomidine, MMA, and haloperidol as effective in preventing POD in the elderly, with atypical antipsychotics ranking highest. However, it is essential to note that these findings should be confirmed through further RCTs.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 169-178"},"PeriodicalIF":3.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and lifestyle predictors of loneliness: A two-year longitudinal study","authors":"Thyago Antonelli-Salgado ,&nbsp;Bruno Braga Montezano ,&nbsp;Thiago Henrique Roza ,&nbsp;Vitória Bouvier ,&nbsp;Aline Zimerman ,&nbsp;Lucas Tavares Noronha ,&nbsp;Grasiela Marcon ,&nbsp;Maurício Scopel Hoffmann ,&nbsp;André Russowsky Brunoni ,&nbsp;Ives Cavalcante Passos","doi":"10.1016/j.jpsychires.2024.11.025","DOIUrl":"10.1016/j.jpsychires.2024.11.025","url":null,"abstract":"<div><h3>Background</h3><div>While loneliness is a global public health problem, the literature lacks studies assessing loneliness predictors in low- and middle-income countries. Therefore, we aimed to analyze clinical and lifestyle predictors of loneliness.</div></div><div><h3>Methods</h3><div>We conducted a 2-year longitudinal study in Brazil based on a snowball sample and online surveys (baseline: May 6 to June 6, 2020). We assessed clinical and lifestyle predictors of loneliness using multiple regression models. The analyses were adjusted for several sociodemographic variables and weighted for attrition and sampling procedures.</div></div><div><h3>Results</h3><div>The study included a nationwide sample of 473 participants (18–75 years; 87.1% females). After adjusting for sociodemographic factors, we identified as risk factors: depressive symptoms (RR: 1.214; 95%CI: 1.08–1.36; p = 0.001), anxiety symptoms (RR:1.191; 95%CI: 1.04–1.35; p = 0.007), alcohol abuse (RR: 1.579; 95%CI: 1.32–1.88; p &lt; 0.001), and cannabis use (RR: 1.750; 95%CI: 1.25–2.39; p &lt; 0.001). More than 150 min/week of physical activity (RR: 0.177; 95%CI: 0.07–0.34; p &lt; 0.001) and good/excellent quality of family relationships (RR: 0.73; 95%CI: 0.60–0.87; p &lt; 0.001) and sleep (RR: 0.483; 95%CI: 0.39–0.59; p &lt; 0.001) were protective factors.</div></div><div><h3>Conclusion</h3><div>Several clinical factors (depression, anxiety, alcohol, and cannabis) have been identified as risk factors for loneliness, while lifestyle factors (physical activity, better quality of sleep, and family relationships) have been associated with a lower incidence of loneliness. Addressing clinical and lifestyle factors may therefore be essential to preventing loneliness.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"180 ","pages":"Pages 482-488"},"PeriodicalIF":3.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental mental disorders and ages of onset of severe mental disorders in offspring: A nationwide family-link study","authors":"Pao-Yuan Ching ,&nbsp;Tien-Wei Hsu ,&nbsp;Shih-Jen Tsai ,&nbsp;Ya-Mei Bai ,&nbsp;Chih-Ming Cheng ,&nbsp;Tung-Ping Su ,&nbsp;Tzeng-Ji Chen ,&nbsp;Chih-Sung Liang ,&nbsp;Mu-Hong Chen","doi":"10.1016/j.jpsychires.2024.11.018","DOIUrl":"10.1016/j.jpsychires.2024.11.018","url":null,"abstract":"<div><h3>Objective</h3><div>The current study used a retrospective study design to investigate the association between age of onset of severe mental disorders in offspring and the likelihood of diagnoses of parental mental disorder.</div></div><div><h3>Method</h3><div>We enrolled 212,333 people with severe mental disorder, including schizophrenia, bipolar disorder (BD), or major depressive disorder (MDD) and 2,123,329 controls matched for age, sex, and demographics from the National Health Insurance Database of Taiwan. Poisson regression models were used to examine the likelihood of diagnoses of five mental disorders in their parents compared to the parents of the controls (reported as odds ratio (OR) with 95% confidence interval), including schizophrenia, BD, MDD, alcohol use disorder (AUD), and substance use disorder (SUD). The study cohort was classified into child-onset, adolescent-onset, and adult-onset groups according to the onset of severe mental disorders in the offspring.</div></div><div><h3>Result</h3><div>The parents of people with child-, adolescent-, and adult-onset schizophrenia (OR range: 1.73–9.08, all p &lt; 0.05) or BD (OR range: 1.97–8.17, all p &lt; 0.05) were more likely to be diagnosed with schizophrenia, BD, MDD, AUD, and substance use disorder (SUD) than controls except for AUD in the child-onset group. However, the parents of people with child-, adolescent-, and adult-onset depressive disorder were more likely to be diagnosed with schizophrenia, BD, MDD, AUD, and SUD (OR range: 1.82–4.76, all p &lt; 0.05) than controls. Sub-analyses stratified by sex showed different patterns of associations between parental mental disorders and offspring mental disorders.</div></div><div><h3>Conclusion</h3><div>No matter when the severe mental disorder of the offsprings occurred at different onset stages, their parents had a higher likelihood of being diagnosed with schizophrenia, BD, MDD, AUD, and SUD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"180 ","pages":"Pages 443-450"},"PeriodicalIF":3.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “German translation and psychometric evaluation of the Mental Health Literacy Scale (MHLS-GER) in a general population sample and in patients with acute myocardial infarction” [J. Psychiat. Res. 178 (2024) 201–209]","authors":"Simone Fischer ,&nbsp;Timo Schmitz ,&nbsp;Christine Meisinger ,&nbsp;Jakob Linseisen ,&nbsp;Inge Kirchberger","doi":"10.1016/j.jpsychires.2024.11.001","DOIUrl":"10.1016/j.jpsychires.2024.11.001","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"180 ","pages":"Pages 380-381"},"PeriodicalIF":3.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in hoarding-related beliefs and associated neural changes during a simulated discarding task after cognitive-behavioral treatment for hoarding disorder","authors":"Kelly A. Knowles ,&nbsp;Michael C. Stevens ,&nbsp;Hannah C. Levy ,&nbsp;David F. Tolin","doi":"10.1016/j.jpsychires.2024.11.017","DOIUrl":"10.1016/j.jpsychires.2024.11.017","url":null,"abstract":"<div><div>Hoarding disorder (HD) is maintained by maladaptive beliefs about possessions, and recent research has demonstrated that changes in these beliefs partially mediate improvement in cognitive-behavioral therapy (CBT) for hoarding. It is not yet known whether changes in neural activity, particularly when discarding possessions, are associated with cognitive change during CBT for HD. Adults who completed group CBT for HD (<em>N</em> = 58) participated in a simulated discarding task before and after CBT. Neural activity was measured using functional magnetic resonance imaging (fMRI) as participants made simulated discarding decisions. At baseline, activity in the left middle insula and left anterior cingulate cortex was significantly associated with hoarding-related beliefs. After receiving CBT for HD, decreases in maladaptive hoarding-related beliefs were significantly associated with increased activity compared to baseline in the right anterior ventral insula, along the left middle frontal gyrus and bilateral inferior temporal lobe, and in visuospatial areas. These results demonstrate that maladaptive beliefs in HD are associated with activation of specific neural regions during discarding decisions and that reduction in beliefs over a course of CBT for HD is associated with specific changes in neural activity.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"180 ","pages":"Pages 473-481"},"PeriodicalIF":3.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-care utilisation and associated economic burden in major depressive disorder and treatment-resistant depression in a longitudinal population-based cohort study of 110.000 patients","authors":"Sofia Pappa ,&nbsp;Moulesh Shah ,&nbsp;Sophie Young ,&nbsp;Tazneem Anwar ,&nbsp;Timothy Ming","doi":"10.1016/j.jpsychires.2024.11.022","DOIUrl":"10.1016/j.jpsychires.2024.11.022","url":null,"abstract":"<div><div>Major depressive disorder (MDD), and particularly treatment-resistant depression (TRD), lead to high levels of health-care use and disease burden. The aim of this study was to evaluate and compare the health-care resource utilisation and associated costs in these patient groups. It was a population-wide, retrospective analysis of NHS health-care electronic records in northwest London using the Discover-NOW platform, one of the largest interlinked datasets in Europe hosted by Imperial College Health Partners, which contains coded emergency and routine, primary and secondary, physical and mental health data, covering a population of more than 2.5 million. Eligible patients were adults with a diagnosis of MDD who had been prescribed at least one antidepressant between 2015 and 2020. A total of 110,406 patients were included, 101,333 [92%] with MDD and 9073 [8%] with TRD. Mean duration of depression was 52.8 (SD 41.7) months for MDD and 70.8 (SD 37.8) months for TRD (p &lt; 0.0001). Patients with TRD had significantly higher risks of both psychiatric and somatic comorbidities such as anxiety, asthma, and alcohol misuse (all p &lt; 0.0001). They also demonstrated increased primary care and emergency attendance rates, more frequent and longer hospitalizations, and on average 1.5 times greater total healthcare costs compared to MDD patients. Primary care visits represented the largest proportion overall (TRD mean 162 [SD 96] vs. MDD 108 [90] visits per patient, p &lt; 0.0001; cost per patient £17,348 [SD £33,040] vs. £12,011 [£25,588], p &lt; 0.0001) during the study period. In secondary care, accident and emergency visits accounted for the highest use (TRD mean 5.5 [10.6] vs. MDD 3.54 [SD 6.0] visits per patient, p &lt; 0.0001) while non-elective hospitalisations incurred the highest costs (mean £2518 [£8064] vs. £1909 [SD £6807], p &lt; 0.0001). Demand increased with the duration of depression and the number of lines of treatment. The study highlights the substantial clinical and economic burden associated with MDD and especially TRD across different care settings.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"180 ","pages":"Pages 511-518"},"PeriodicalIF":3.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and feasibility of four standardized aerobic fitness tests in patients with depression: A cross-sectional study","authors":"Markus Gerber ,&nbsp;Timon Schilling ,&nbsp;Sebastian Ludyga ,&nbsp;Oliver Faude ,&nbsp;Arno Schmidt-Trucksäss ,&nbsp;Robyn Cody ,&nbsp;Doris Straus ,&nbsp;Anke Schneiders ,&nbsp;Gavin Brupbacher","doi":"10.1016/j.jpsychires.2024.11.019","DOIUrl":"10.1016/j.jpsychires.2024.11.019","url":null,"abstract":"<div><div>The objective of this study was to examine the validity and feasibility of four standardized aerobic fitness tests to either measure <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂peak or to estimate <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂max (e <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂max) in patients with major depression disorder (MDD). To this end, all subjects (n = 43) performed one maximal cardiopulmonary exercise test with gas exchange measurement (CPET) on a bicycle ergometer. Additionally, three submaximal tests (Åstrand-Rhyming bicycle ergometer test [ART], Physical work capacity test [PWC], and 6-min walk test [6MWT]) were performed within two weeks in counterbalanced order. e <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂max from the submaximal tests was compared to the measured <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂peak from CPET using rANOVAs, Bland-Altman plots, and correlation analyses. Feasibility outcomes (e.g., perceived exertion, discomfort, pretest anxiety, etc.) were compared via rANOVAs. On group level, e <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂max estimated submaximally via ART and PWC did not differ from the CPET-based <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂peak, whereas there was a bias in the 6MWT, as differences of the means increased in participants with higher <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂peak. During CPET, only 56% achieved a primary or secondary criterion of maximum (physiological) exertion. On the group level, <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂peak and e <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂max determined with the different tests showed a sufficient degree of agreement (<em>r</em> ≥ 0.54, ICCs≥0.66, <em>p</em> &lt; 0.001), but on the individual level, marked differences occurred between CPET-based <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂peak and e <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂max. Three of four CRF tests (CPET, ART, PWC) proved to be feasible and could be integrated into everyday therapy and monitoring of patients with MDD as an estimate for improvement of aerobic fitness. For the exact measurement of <span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover></mrow></math></span> O₂peak, CPET remains the gold standard, also in patients with MDD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 116-125"},"PeriodicalIF":3.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}