Journal of psychiatric research最新文献

{"title":"Comparative cardiac safety of haloperidol vs. chlorpromazine among people receiving hemodialysis","authors":"Rebekah P. Nash ,&nbsp;Sherin Ismail ,&nbsp;Bradley N. Gaynes ,&nbsp;Jennifer E. Flythe","doi":"10.1016/j.jpsychires.2025.05.065","DOIUrl":"10.1016/j.jpsychires.2025.05.065","url":null,"abstract":"<div><h3>Background</h3><div>Sudden cardiac death (SCD) is &gt; 20 times more likely among individuals receiving maintenance hemodialysis, relative to individuals not receiving hemodialysis. Typical antipsychotics increase risk for QT prolongation and SCD in the general population. The comparative cardiac safety of typical antipsychotics among individuals receiving hemodialysis is unknown.</div></div><div><h3>Methods</h3><div>This cohort study used an active comparator, new-user design to examine relative cardiac safety of the most frequently prescribed oral typical antipsychotics among individuals receiving outpatient maintenance hemodialysis (2007–2019). Data were obtained from the U.S Renal Data System. The primary outcome was 1-year risk of SCD. Inverse probability of treatment weighted Fine and Gray models estimated adjusted hazard ratios (aHR) and adjusted risk differences (aRDs), with 95 % confidence intervals (CIs), using an intention-to-treat approach. In primary analyses, deaths due to causes other than SCD were competing events.</div></div><div><h3>Results</h3><div>Among 846,400 maintenance hemodialysis patients (2007–2019), haloperidol (n = 10,813) and chlorpromazine (n = 5800) were the most commonly prescribed oral typical antipsychotics. Among 6266 haloperidol and 3959 chlorpromazine new-users, 662 (9.9 %) and 234 (5.9 %), respectively, experienced SCD by 1-year. Compared to chlorpromazine new-use, Haloperidol new-use was associated with higher 1-year risk of SCD, aHR (95 % CI) = 1.38 (1.21,1.59); aRD (95 % CI) = 2.62 % (−0.27 %, 5.51 %). Analyses of additional cardiac outcomes yielded similar findings.</div></div><div><h3>Conclusions</h3><div>Haloperidol was the most prescribed oral typical antipsychotic. Haloperidol new-use associated with a higher 1-year risk of SCD and other adverse cardiac outcomes compared to chlorpromazine new-use. Caution and close monitoring are warranted when newly prescribing haloperidol to individuals receiving hemodialysis.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 235-242"},"PeriodicalIF":3.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and psychometric properties of the severity assessment scale for pediatric attention-deficit hyperactivity disorder (ADHD)","authors":"Tianqi Wang ,&nbsp;Zhongbi Peng ,&nbsp;Zhaojing Tai ,&nbsp;Hongzhu Deng ,&nbsp;Mingjing Situ ,&nbsp;Lan Zhang ,&nbsp;Yi Wang ,&nbsp;Hao Zhou","doi":"10.1016/j.jpsychires.2025.05.067","DOIUrl":"10.1016/j.jpsychires.2025.05.067","url":null,"abstract":"<div><h3>Background</h3><div>While several scales assess functional impairment in pediatric Attention-deficit hyperactivity disorder (ADHD), there remains a paucity of well-validated measures specifically designed to evaluate impairment severity across multiple functional domains. This study aims to develop a novel scale for evaluating the severity of ADHD in children and to analyses its reliability and validity.</div></div><div><h3>Methods</h3><div>A preliminary pool of items was created based on a literature review and some expert opinions. Exploratory factor analysis, along with internal consistency, and reliability tests were conducted.</div></div><div><h3>Results</h3><div>We developed a 7-item severity assessment scale specifically designed for pediatric ADHD, which serves as a brief parents-report measure of ADHD severity by evaluating its functional impacts. The confirmatory sample included 81 parents of children diagnosed with ADHD, aged 6–14 years. Through exploratory factor analysis revealed a one-factor structure, indicating the scale's overall goodness of fit. The scale exhibited strong internal consistency with a Cronbach's α of 0.83. Additionally, it demonstrated significant content validity, convergent validity, and discriminant validity.</div></div><div><h3>Conclusion</h3><div>These findings demonstrated that the 7-item severity assessment scale for pediatric ADHD is a valid and reliable instrument. Future research should employ this scale to accurately measure the severity of ADHD in children.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 229-234"},"PeriodicalIF":3.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse reactions among psychedelic users: Norwegian validation of the Challenging Experience Questionnaire","authors":"Kristoffer A.A. Andersen ,&nbsp;Bjørn Holmøy ,&nbsp;Tor-Morten Kvam ,&nbsp;Matthew W. Johnson","doi":"10.1016/j.jpsychires.2025.05.062","DOIUrl":"10.1016/j.jpsychires.2025.05.062","url":null,"abstract":"<div><div>Psychedelic drugs, known for their potent psychoactive effects, have gained attention for their potential therapeutic benefits in treating mental disorders. However, distressing experiences induced by psychedelics can lead to adverse long-term effects. To better assess these experiences, we aimed to provide a Norwegian translation and psychometric validation of the Challenging Experience Questionnaire (CEQ), a key tool for evaluating adverse psychedelic experiences. Our study employed an anonymous online survey targeting Norwegian recreational psychedelic users, focusing on their most memorable psychedelic encounter. A sample of 729 participants, predominantly male (73 %) and aged between 26 and 35 years (41 %), with 90 % having used LSD or psilocybin, was analyzed. Half of the participants had completed a university degree, and 48 % reported a diagnosed mental disorder. The CEQ underwent a rigorous seven-stage translation process and was included in the survey to validate the original 7-factor structure. Our findings revealed excellent internal consistency (alpha = 0.94) and robust overall model fit (χ²[278] = 1451.80, RMSEA = 0.076, SRMR = 0.051, CFI = 0.913) for the 7-factor model, with evidence of factorial invariance across gender and psychiatric status. Further, the relationship between reported difficulty and CEQ factors such as fear, grief, insanity, and death underscored its convergent validity. In conclusion, our study confirms the 7-factor structure of the CEQ while demonstrating its reliability and validity. This provides Norwegian researchers with a culturally adapted, psychometrically valid tool for assessing complex adverse reactions to psychedelic use.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 18-25"},"PeriodicalIF":3.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of choral singing on depression and anxiety in older adults: A randomized controlled trial","authors":"Ted K.S. Ng ,&nbsp;Zhi Hao Lim ,&nbsp;Michael Todd ,&nbsp;Fei Sun ,&nbsp;Kendra Ray ,&nbsp;Xiang Qi ,&nbsp;Jiuyu Guo ,&nbsp;Kaisy Xinhong Ye ,&nbsp;Andrea B. Maier ,&nbsp;Rathi Mahendran ,&nbsp;Goh Lee Gan ,&nbsp;Maurine Tsakok ,&nbsp;Ee Heok Kua ,&nbsp;Lei Feng","doi":"10.1016/j.jpsychires.2025.05.061","DOIUrl":"10.1016/j.jpsychires.2025.05.061","url":null,"abstract":"<div><h3>Introduction</h3><div>Few randomized controlled trials (RCTs) have investigated the effects of choral singing (CS) on older adults at-risk of cognitive decline and dementia. Extant RCTs on CS also lack an active control arm controlling for non-intervention-specific active components.</div></div><div><h3>Methods</h3><div>In this parallel-arm, open-label RCT, 200 community-dwelling older adults at-risk of cognitive decline were randomized to the treatment arm, i.e., CS, or the active control arm (i.e., health education program, i.e., HEP, matched with non-intervention-specific components). Both arms involved weekly 1-h group sessions held continuously for two years. We examined the <em>a priori</em> registered secondary outcomes, positive screens for depressive and anxiety disorders, at baseline, 1-year, and 2-year time-points, using linear-mixed models with intention-to-treat.</div></div><div><h3>Results</h3><div>Compared to the HEP, CS participants experienced similar decreased odds of positive screens for depressive and anxiety disorders throughout all the time-points, though different trajectories.</div></div><div><h3>Discussion</h3><div>In contrary to previous studies using passive controls reporting positive outcomes, compared to HEP as an active comparator, CS is as effective as HEP in delaying progression to clinically significant depressive and anxiety disorders in at-risk community-dwelling older adults. Our findings highlight the critical importance of incorporating an intervention-components-matched comparison arm in non-pharmacological interventions.</div></div><div><h3>Trial registration</h3><div>Choral Singing For the Prevention of Dementia, <span><span>https://clinicaltrials.gov/study/NCT02919748</span><svg><path></path></svg></span>; Trial Registration: NCT02919748.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 162-168"},"PeriodicalIF":3.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Longitudinal Studies Assessing Personality and Burnout","authors":"Andrew M. Camara ,&nbsp;Gordon Parker","doi":"10.1016/j.jpsychires.2025.05.064","DOIUrl":"10.1016/j.jpsychires.2025.05.064","url":null,"abstract":"<div><div>Burnout is generally conceptualised as the consequence of precipitating work stressors. However, most psychiatric conditions are best captured by an interaction between predisposing factors and environmental stressors (i.e., a diathesis-stress model). As some studies have implicated certain personality traits as risk factors to burnout the current review sought to identify salient ones by evaluating published longitudinal studies. Three databases were subjected to a literature search using keywords relating to personality, burnout and longitudinal studies. This literature search yielded 59 eligible studies assessing 18 personality traits. Studies were assessed for methodological quality and key findings extracted. Two personality traits - neuroticism and perfectionistic concerns – emerged as candidates increasing risk. In addition, we identified several personality characteristics that appear to lower the risk of burnout. Findings have the potential to advance causal theorising by highlighting the aetiological contribution of personality as a diathesis factor, which may have distinct implications for the management of burnout.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of eveningness with occupational outcomes in mental disorders: the Northern Finland Birth Cohort 1966","authors":"Tuomas Majuri ,&nbsp;Sanna Huikari ,&nbsp;Marko Korhonen","doi":"10.1016/j.jpsychires.2025.05.044","DOIUrl":"10.1016/j.jpsychires.2025.05.044","url":null,"abstract":"<div><h3>Background</h3><div>The impact of mental health and chronotype on occupational outcomes has been examined, most of the studies linking mental disorders and eveningness with unfavourable occupational outcomes. However, no previous studies have explored the significance of chronotype in income and labour market attachment among individuals with mental disorders.</div></div><div><h3>Method</h3><div>Utilizing the Northern Finland Birth Cohort 1966 with linkages to registers and questionnaire data, we compared income and labour market attachment until midlife among individuals with 1) morning or intermediate type (M/I-type) and no mental disorder (reference group), 2) evening type (E-type) and no mental disorder, 3) M/I-type and mental disorder, and 4) E-type and mental disorder by using cross-tabulations and regression analyses. We stratified our analysis by sex.</div></div><div><h3>Results</h3><div>Compared to the reference group, E-types with mental disorders had the lowest cumulative income irrespective of sex. Among females, E-types with mental disorders had the highest risk for poor labour market attachment when compared to the reference group (OR (95 % CI) 2.33 (1.30–4.16)). Among males, M/I-types with mental disorders had heightened odds for poor labour market attachment (OR (95 % CI) 2.25 (1.55–3.27)), whereas for E-types with mental disorders, the risk was slightly non-significant (OR (95 % CI) 2.13 (0.95–4.78)).</div></div><div><h3>Conclusion</h3><div>This study highlights the significance of chronotype in income and labour market attachment among individuals with mental disorders. From the perspectives of healthcare and employers, individual interventions to support work ability should be targeted at E-types with mental disorders, as eveningness may contribute to poorer occupational outcomes in this group.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 29-36"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal perinatal depressive disorders and the risk of attention deficit and hyperactivity disorder in offspring: A linked data study","authors":"Biruk Shalmeno Tusa ,&nbsp;Rosa Alati ,&nbsp;Kim Betts ,&nbsp;Getinet Ayano ,&nbsp;Berihun Dachew","doi":"10.1016/j.jpsychires.2025.05.058","DOIUrl":"10.1016/j.jpsychires.2025.05.058","url":null,"abstract":"<div><h3>Background</h3><div>This study examines the risk of Attention-Deficit/Hyperactivity Disorder (ADHD) in offspring of mothers with perinatal depressive disorders, considering direct and indirect pathways through adverse birth outcomes.</div></div><div><h3>Methods</h3><div>The study employed a retrospective cohort design, utilising administrative-linked health data from New South Wales. Maternal perinatal depressive disorders and offspring ADHD were identified using the International Classification of Diseases, Tenth Revision, Australian Modification (ICD-10-AM .) codes. A generalised linear model with a binomial distribution and log link function was used to estimate the direct association. Additionally, a mediation analysis was conducted to examine the mediating effects of low birth weight, low Apgar scores, and preterm birth on the association between maternal antenatal depressive disorder and offspring ADHD.</div></div><div><h3>Results</h3><div>After adjusting for confounders, offspring of mothers with antenatal, postnatal, and perinatal depressive disorders had 2.10 (95 % CI: 1.46–3.03), 1.80 (95 % CI: 1.11–2.92), and 2.16 (95 % CI: 1.57–2.97) times greater risk of ADHD, respectively. Preterm birth minimally mediated the relationship between antenatal depression and ADHD, accounting for only 0.73 % of the total effect, which was about 45 times smaller than the direct effect. Low birth weight and low Apgar scores did not mediate this relationship.</div></div><div><h3>Conclusion</h3><div>Our study revealed that maternal perinatal depressive disorders are associated with an increased risk of offspring ADHD, with very minimal or no mediating effects from adverse birth outcomes. Therefore, implementing early intervention strategies aimed at improving maternal mental health is crucial to reducing the risk of ADHD in children.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 169-175"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of treatment on the quality of life of patients with obsessive-compulsive disorder: systematic review and meta-analysis","authors":"Samara dos Santos-Ribeiro ,&nbsp;Gabriela B. de Menezes ,&nbsp;Maria E. Moreira-de-Oliveira ,&nbsp;Verônica Hühne ,&nbsp;Pedro P. Fortes ,&nbsp;Leonardo F. Fontenelle","doi":"10.1016/j.jpsychires.2025.05.036","DOIUrl":"10.1016/j.jpsychires.2025.05.036","url":null,"abstract":"<div><div>This systematic review and meta-analysis investigated whether treatments for obsessive-compulsive disorder (OCD) are associated not only with decreases in symptom severity but also with improvements in quality of life (QoL). A systematic search of PUBMED, PsycInfo, Scopus, Web of Science and ClinicalTrials databases was performed. The inclusion criteria involved RCTs that investigated adults diagnosed with OCD and incorporated evaluations of baseline and endpoint assessments for QoL and OCD symptom severity. The search found 3872 records, with 19 remaining after all screening process. Most of the studies investigated psychological interventions, categorizable into clusters of CBT-based treatments, interventions with meditation components, and augmentation strategies. This categorization was utilized to perform subgroup analysis. All subgroup interventions had a non-significant effect on QoL, except for CBT-based treatments, which demonstrated a statistically significant difference when compared to waiting lists. Regarding the effect of the interventions on the severity of OCD symptoms, the effect sizes were small for CBT-based treatments and medium for interventions with meditation components and augmentation strategies. The CBT-based treatments lead to some improvement in QoL of people with OCD (when compared to no treatment). Evidence suggested that treatments incorporating meditation components or augmentation treatments lead to improvements in OCD symptoms unparalleled by QoL improvement. Further studies are needed to assess pre- and post-intervention QoL measures for a more robust conclusion. This can facilitate the identification of more beneficial and effective treatments, both in reducing symptoms and improving QoL.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 19-28"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of probiotics, prebiotics, and synbiotics on depression and anxiety symptoms of patients with depression: A systematic review and meta-analysis","authors":"Reza Moshfeghinia ,&nbsp;Hossein Nemati ,&nbsp;Asal Ebrahimi ,&nbsp;Dorsa Shekouh ,&nbsp;Saeed Karami ,&nbsp;Mohammad Mirahmadi Eraghi ,&nbsp;Hoorad Mohagheghzadeh ,&nbsp;Jennifer Hunter ,&nbsp;Mehdi Pasalar","doi":"10.1016/j.jpsychires.2025.05.053","DOIUrl":"10.1016/j.jpsychires.2025.05.053","url":null,"abstract":"<div><h3>Introduction</h3><div>Depression is a prevalent mental health disorder with significant societal impact and treatment challenges. Recent research on the gut-brain axis has led to interest in probiotics, synbiotics, and prebiotics as potential therapeutic options for depression. This systematic review aims to evaluate their effects and provide evidence-based insights for future research and clinical practice.</div></div><div><h3>Methods</h3><div>Six digital databases (Scopus, PubMed, Web of Science, Cochrane, PsycINFO, and CINAHL complete) were examined for English-language records. Inclusion criteria involved studies assessing the impact of probiotics, prebiotics, and synbiotic on depression and anxiety in individuals with depression. The Cochrane Collaboration's instrument was employed to evaluate the risk of bias. For meta-analysis, random-effects model was favored, and statistical analysis was conducted using Stata software version 17.</div></div><div><h3>Results</h3><div>From initial 4407 studies 19 studies included in meta-analysis. A meta-analysis of 19 studies involving 1405 participants (882 cases and 523 controls) revealed a significant decrease in depression scores among patients receiving probiotics, prebiotics, or synbiotics compared to the control group (SMD: −1.76 [-2.42, −1.10]), despite high heterogeneity between studies (I²: 96.29 %). Similarly, analysis of seven studies with 481 participants (237 cases and 244 controls) showed a significant decrease in anxiety scores for those receiving these supplements (SMD: −1.60 [-2.83, −0.36]), with high heterogeneity between studies (I²: 96.90 %).</div></div><div><h3>Conclusion</h3><div>In conclusion, our meta-analysis indicates that probiotics, prebiotics, or synbiotics significantly reduce depression and anxiety symptoms in patients with depression. Future research should address heterogeneity in diagnosis and intervention types to better understand their efficacy.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 104-116"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic benefit versus epistemic risk: Need for empirical research in psychedelic epistemology","authors":"Lucas F. Borkel ,&nbsp;Jaime Rojas-Hernández ,&nbsp;Domingo J. Quintana-Hernández ,&nbsp;Luis Alberto Henríquez-Hernández","doi":"10.1016/j.jpsychires.2025.05.039","DOIUrl":"10.1016/j.jpsychires.2025.05.039","url":null,"abstract":"<div><div>This paper highlights the ethical and epistemic challenges posed by psychedelic therapy and vindicates the importance of epistemology in the clinical and psychotherapeutic setting. Despite their relative physiological and psychological safety, these substances can induce changes in the beliefs of those who use them, such as paranormal beliefs. To explain the changes in beliefs, we introduced the concept of epistemic criteria (i.e., the principles individuals use to validate and justify their beliefs) and hypothesized that psychedelics may alter beliefs by modifying epistemic criteria. Further research should be conducted to determine this potential and under-researched risk of psychedelic therapy.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 117-125"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}