Journal of psychiatric research最新文献_第8页

Aberrant activity at rest of the associative striatum in schizophrenia: Meta-analyses of the amplitude of low frequency fluctuations 精神分裂症患者联想纹状体静息时的异常活动：低频波动振幅的元分析

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-11 DOI: 10.1016/j.jpsychires.2024.09.012

{"title":"Aberrant activity at rest of the associative striatum in schizophrenia: Meta-analyses of the amplitude of low frequency fluctuations","authors":"","doi":"10.1016/j.jpsychires.2024.09.012","DOIUrl":"10.1016/j.jpsychires.2024.09.012","url":null,"abstract":"<div><p>Schizophrenia is a severe psychiatric disorder associated with brain alterations at rest. Amplitude of low-frequency fluctuations (ALFF) and its fractional version (fALFF) have been widely used to investigate alterations in spontaneous brain activity in schizophrenia. However, results are still inconsistent. Furthermore, while these measurements are similar, they showed some differences, and no meta-analysis has been yet performed to compare them in schizophrenia. Thus, we conducted systematic research in five databases and in the grey literature to find articles investigating fALFF and/or ALFF alterations in schizophrenia. Two separate meta-analyses were performed using the SDM-PSI software to identify fALFF and ALFF alterations separately. Then, a conjunction analysis was conducted to determine congruent results between the two approaches. We found that patients with schizophrenia showed altered fALFF activity in the left insula/putamen, the right paracentral lobule and the left middle occipital gyrus compared to healthy individuals. Patients with schizophrenia exhibited ALFF alterations in the bilateral putamen, the bilateral caudate nucleus, the bilateral inferior frontal gyrus, the right precuneus, the right precentral gyrus, the left postcentral gyrus, the right posterior cingulate gyrus, compared to healthy controls. ALFF increased activity in the left putamen was higher in drug-naïve patients and was correlated with positive symptoms. The conjunction analysis revealed a spatial convergence between fALFF and ALFF studies in the left putamen. This left putamen cluster is part of the associative striatum. Its alteration in schizophrenia provides additional support to the influential aberrant salience hypothesis of psychosis.</p></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weak and interfered self-control fails to block problematic mobile phone use: The role of craving and desire thinking 自制力弱和受干扰的人无法阻止有问题的手机使用：渴望和欲望思维的作用

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-10 DOI: 10.1016/j.jpsychires.2024.09.004

{"title":"Weak and interfered self-control fails to block problematic mobile phone use: The role of craving and desire thinking","authors":"","doi":"10.1016/j.jpsychires.2024.09.004","DOIUrl":"10.1016/j.jpsychires.2024.09.004","url":null,"abstract":"<div><div>Problematic mobile phone use (PMPU) has become a worldwide phenomenon with negative impacts on adolescents’ daily lives. While self-control has been shown to be related to PMPU, little is known about the underlying mechanisms of this association. Based on the Interaction of Person-Affect-Cognition-Execution model and the strength model of self-control, the current study aims to examine the association between self-control and PMPU, to identify the indirect role of craving, and to determine whether and how the two components of desire thinking exert differential moderating effects. A sample of 1424 adolescents was recruited to complete the scales of self-control, craving, desire thinking, and PMPU. The results suggested that self-control was indirectly associated with PMPU through craving. Furthermore, this indirect association was moderated by verbal perseveration, rather than imaginal prefiguration. Specifically, the indirect association was stronger for adolescents with higher verbal perseveration. The findings deepen our understanding of how self-control is related to PMPU and distinguish the effects of two components of desire thinking among adolescents.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Results from a randomized controlled trial of zonisamide in the treatment of alcohol use disorder 唑尼沙胺治疗酒精使用障碍的随机对照试验结果

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-10 DOI: 10.1016/j.jpsychires.2024.08.044

{"title":"Results from a randomized controlled trial of zonisamide in the treatment of alcohol use disorder","authors":"","doi":"10.1016/j.jpsychires.2024.08.044","DOIUrl":"10.1016/j.jpsychires.2024.08.044","url":null,"abstract":"<div><p>There is preliminary evidence that the anticonvulsant medication Zonisamide (ZON) may be an effective, well-tolerated treatment for alcohol use disorder (AUD). However, further evaluation of its efficacy for treating patients with AUD is needed, and much remains unknown about ZON's therapeutic mechanisms. The present study aimed to evaluate the efficacy and tolerability of ZON in a double-blind, placebo-controlled, randomized trial. Eighty-one adults (ages 21–65) diagnosed with AUD were randomly assigned to receive either ZON (at a target dose of 400 mg/d) or a pill placebo over 12 weeks, followed by a two-week taper. All participants also received a computerized alcohol reduction program, Take Control (TC). Primary drinking outcomes were average daily drinks, percentage drinking days, and percentage heavy drinking days. Further, we evaluated changes in AUD clinical severity and performance on neuropsychological measures. For both groups, drinking outcomes generally decreased, as did AUD clinical severity, though group differences were not statistically significant. Neuropsychological testing performance was similar for both groups at baseline; however, at post-treatment, participants in the ZON group demonstrated poorer working memory and lower performance on verbal fluency tests compared to the placebo group, and these differences were statistically significant with moderate-large effect sizes. One serious adverse event was reported among individuals receiving ZON. Study findings indicate that ZON combined with TC does not demonstrate superior effectiveness for reducing average daily drinks in this clinical sample with principal AUD compared to placebo and TC, and treatment with ZON may be associated with reduced neurocognitive performance over time.</p></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parental substance use disorders and psychiatric conditions in offspring: A Swedish population-based cohort study with over 1,000,000 individuals 父母药物使用失调与后代的精神状况：一项基于瑞典 100 多万人口的队列研究

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-10 DOI: 10.1016/j.jpsychires.2024.09.010

{"title":"Parental substance use disorders and psychiatric conditions in offspring: A Swedish population-based cohort study with over 1,000,000 individuals","authors":"","doi":"10.1016/j.jpsychires.2024.09.010","DOIUrl":"10.1016/j.jpsychires.2024.09.010","url":null,"abstract":"<div><h3>Background</h3><p>Exposure to parental substance use problems has been associated with offsprings poor health and adverse social outcomes. In this study, we examined the association between exposure to parental substance use disorder (SUD) during childhood, and adolescence and offspring psychiatric conditions in young adulthood.</p></div><div><h3>Method</h3><p>This was a register-based cohort study comprising 562,095 males and 531,130 females born between 1981 and 1990 in Sweden. Parental SUD was captured between the offspring's birth and eighteenth birthday. Cox regression models were used to estimate the Hazard Ratio (HR) of psychiatric conditions from age 18 years to a maximum age of 35 years, from January 1, 1999 to December 31, 2016.</p></div><div><h3>Results</h3><p>About 4% of the study population was exposed to parental SUD during childhood and adolescence. The HR of psychiatric diagnosis was higher in males (1.80, 95% CI = 1.77–1.85) and females (1.56, 95% CI = 1.51–1.60) who were exposed to parental SUD, compared to those who were not; after adjusting for year of birth, domicile, origin, relative poverty, and other parental psychiatric diagnoses. The risks of psychiatric conditions were higher among males and females exposed to parental SUD during childhood compared to during adolescence.</p></div><div><h3>Conclusion</h3><p>Exposure to parental SUD during childhood and adolescence was associated with an increased risk of psychiatric conditions in early adulthood for both males and females. Neither origin, poverty, municipality, or other parental psychiatric diagnoses fully explained the association. These risks seemed to be somewhat higher among males, and among those exposed during childhood when compared to during adolescence.</p></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022395624005326/pdfft?md5=fefcab0c384905d146325321d3586cbb&pid=1-s2.0-S0022395624005326-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cells improve depressive disorder via inhibiting the inflammatory polarization of microglia 间充质干细胞通过抑制小胶质细胞的炎症极化改善抑郁障碍

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-08 DOI: 10.1016/j.jpsychires.2024.09.005

引用次数: 0

Characterization of pain and somatization and its relationship with psychopathology in early onset psychosis 早期精神病患者疼痛和躯体化的特征及其与精神病理学的关系

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-07 DOI: 10.1016/j.jpsychires.2024.09.006

{"title":"Characterization of pain and somatization and its relationship with psychopathology in early onset psychosis","authors":"","doi":"10.1016/j.jpsychires.2024.09.006","DOIUrl":"10.1016/j.jpsychires.2024.09.006","url":null,"abstract":"<div><h3>Background</h3><p>Early onset psychosis (EOP) frequently presents with a severe clinical phenotype and poor long-term prognosis. Clinical experience suggests that individuals with EOP have abnormal pain and somatosensory processing, yet relative to adult-onset psychosis, pain and somatic sensory processing in EOP have rarely been studied.</p></div><div><h3>Methods</h3><p>The history of two characteristic patients is described to illustrate clinical presentations of pain in EOP patients. Furthermore, 31 patients with EOP were studied with self-reported questionnaires informing on pain severity, pain catastrophizing, central sensitization, and somatization. Structured clinical interviews were administered to confirm Diagnostic and Statistical Manual of Mental Disorders-5 EOP diagnosis and the patient's dimensions of psychopathology were measured by the Brief Psychiatric Rating Scale (BPRS).</p></div><div><h3>Results</h3><p>Out of 31 EOP patients, 22 reported distressing pain, where higher pain severity corresponded with greater BPRS total and affectivity and resistance subscale scores. The degree of psychopathology was associated (N = 31; p < 0.05, FDR-corrected) with the magnitude of pain catastrophizing, central sensitization, and somatization. Multivariate analysis revealed relationships (N = 31; p < 0.05, FDR-corrected) between BPRS subscale (negative symptoms and activation) scores with somatization severity. The observed associations occurred independent of antipsychotic medication usage as quantified by chlorpromazine equivalent doses.</p></div><div><h3>Conclusions</h3><p>Pain and somatosensory symptoms could be a frequent cause of distress in patients with EOP and their severity associated with the degree of psychopathology. Future studies should determine if treating pain and somatic symptoms in EOP patients can lead to better control of psychosis as well as improve quality of life.</p></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Ketamine alleviates PTSD like effect and improves hippocampal synaptic plasticity via regulation of GSK-3β/GR signaling of rats” [J. Psychiatr. Res. 178 (2024) 259–269] 氯胺酮通过调节 GSK-3β/GR 信号转导减轻创伤后应激障碍样效应并改善大鼠海马突触可塑性》[J. Psychiatr. Res. 178 (2024) 259-269] 的更正。

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-07 DOI: 10.1016/j.jpsychires.2024.09.001

引用次数: 0

Level of selected exponents of the kynurenine pathway in patients diagnosed with depression and selected cancers 被诊断患有抑郁症和某些癌症的患者体内犬尿氨酸途径某些指数的水平

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-07 DOI: 10.1016/j.jpsychires.2024.09.008

{"title":"Level of selected exponents of the kynurenine pathway in patients diagnosed with depression and selected cancers","authors":"","doi":"10.1016/j.jpsychires.2024.09.008","DOIUrl":"10.1016/j.jpsychires.2024.09.008","url":null,"abstract":"<div><p>Altered immune system activity is one of the common pathomechanisms of depressive disorders and cancer. The aim of this study is to evaluate level of selected elements of the kynurenine pathway in groups of depressed and oncological patients. The study included 156 individuals, aged 19–65 years (<em>M = 43</em>.46, <em>SD = 13</em>.99), divided into three groups, namely depressive disorders (DD), oncology patients (OG), and a comparison group of healthy subjects (CG). A sociodemographic questionnaire and the Hamilton Depression Rating Scale (HDRS) were used in the study to assess the intensity of depressive symptoms. Level of TDO2, L-KYN, HK, AA and QA was significantly higher in patients from OG and DD groups than in the comparison group. TDO2 level in the OG group was positively correlated with the severity of depressive symptoms. When the OG and DD groups were analyzed together, level of TDO2, 3-HKYN, AA, QA correlated positively with the severity of depressive symptoms. Thus, kynurenine pathway might play an integral role in the pathogenesis of depression.</p></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022395624005302/pdfft?md5=30c94bbcb19ac61e8031db8433cd6e28&pid=1-s2.0-S0022395624005302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal trends of suicidality among hospitalised adolescents during COVID-19 pandemic: A Bayesian framework COVID-19大流行期间住院青少年自杀的时间趋势：贝叶斯框架

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-06 DOI: 10.1016/j.jpsychires.2024.09.007

{"title":"Temporal trends of suicidality among hospitalised adolescents during COVID-19 pandemic: A Bayesian framework","authors":"","doi":"10.1016/j.jpsychires.2024.09.007","DOIUrl":"10.1016/j.jpsychires.2024.09.007","url":null,"abstract":"<div><h3>Objective</h3><p>Literature on temporal patterns of suicidality among youths during the COVID-19 pandemic is growing. The present work proposes a Bayesian approach to assess temporal patterns of suicide-related behaviours among inpatient adolescents during the COVID-19 pandemic.</p></div><div><h3>Methodology</h3><p>Data referred to the first hospital discharge record with ICD9-CM codes related to suicide-related behaviour and/or suicidal ideation among adolescents aged 13–19 between 1 January 2017 and 31 March 2021 were collected in the Piedmont region, Italy (n = 334; median age: 15 years, IQR: 14–16; 80% girls). A Poisson Bayesian regression model performed on pre-COVID-19 data (2017–2020), adjusted by seasonality and stratified by sex, was adopted to provide the probability that the predicted counts exceed the observed ones in each pandemic year quarter.</p></div><div><h3>Results</h3><p>A declining trend of suicidality was observed in April–June 2020 among both sex groups. Among females, an increasing pattern of suicidality was registered in early 2021 (January–March) compared to the pre-pandemic period.</p></div><div><h3>Conclusion</h3><p>The present findings contributed to a growing literature on the COVID-19 pandemic's impact on adolescents' suicide-related behaviours from a gender perspective and encouraged wider adoption of Bayesian approaches as valuable tools to explore rare events and deeply enlighten open public health issues.</p></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: Comment on Schuch et al., “Exercise as a treatment for depression: A meta-analysis adjusting for publication bias” 致编辑的信：评论 Schuch 等人，"运动可治疗抑郁症：调整出版偏差的荟萃分析 "一文发表的评论。

IF 3.7 2区医学

Journal of psychiatric research Pub Date : 2024-09-06 DOI: 10.1016/j.jpsychires.2024.08.045

引用次数: 0