Journal of psychiatric research最新文献

{"title":"Risk and protective factors that distinguish United States veterans with a history of suicidal ideation and suicide attempt","authors":"David P. Cenkner,&nbsp;Alyson K. Zalta","doi":"10.1016/j.jpsychires.2025.05.059","DOIUrl":"10.1016/j.jpsychires.2025.05.059","url":null,"abstract":"<div><div>Many risk and protective factors for suicidal thoughts and behaviors among United States veterans are known. However, factors differentiating veterans who endorse suicidal ideation to veterans who engage in suicide attempts are understudied. The current study examined factors that distinguished these two groups using the Military Health and Well-Being Project, an online dataset of 1495 veterans that oversampled for female and Black veterans. Veterans (<em>N</em> = 620; 39 % female; 15 % Black) were grouped by those who endorsed a history of suicidal thoughts (<em>n</em> = 548) or suicide attempts (<em>n</em> = 72). Independent samples <em>t</em>-tests were conducted to examine differences in individual risk and protective factors. A binary logistic regression was conducted to examine which factors uniquely distinguished between veterans with past ideation and veterans with past attempts. Compared to veterans with past ideation, those with past attempts had higher scores on moral injury (<em>d</em> = −0.80; <em>p</em> &lt; .001), substance use (<em>d</em> = −0.72; <em>p</em> &lt; .001), and loneliness (<em>d</em> = −0.62; <em>p</em> &lt; .001) and lower scores on meaning and purpose in life (<em>d</em> = 0.89; <em>p</em> &lt; .001) and social support (<em>d</em> = 0.61; <em>p</em> &lt; .001). When collectively examined, female gender (OR = 2.37), endorsing lower meaning and purpose in life (OR = 0.55) and endorsing greater substance use (OR = 1.81) were unique predictors of attempting suicide. Findings suggest the importance of assessing and targeting meaning and purpose in life and substance use in veterans endorsing suicidal ideation to potentially prevent the transition to attempting suicide.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 126-132"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of the Japanese version of the Misophonia Questionnaire (MQ)","authors":"Chihiro Itoi ,&nbsp;Yuta Ujiie ,&nbsp;Makio Kashino","doi":"10.1016/j.jpsychires.2025.05.040","DOIUrl":"10.1016/j.jpsychires.2025.05.040","url":null,"abstract":"<div><div>The Misophonia Questionnaire (MQ) is a self-report measure designed to assess misophonia symptoms. It has been validated in various languages and across different samples. However, no prior research has validated the MQ in Japanese samples. This study aimed to develop a Japanese version of the Misophonia Questionnaire (MQ-J) and examine its psychometric properties. This study confirmed the score distribution, internal consistency, and factor structure in a Japanese sample via an online survey. We also compared the MQ-J scores between individuals with misophonia symptoms and control participants. Additionally, we examined the relationships between the MQ-J and sensory processing issues, obsessive-compulsive tendencies, anxiety, depressive symptoms, and difficulties in daily life. Results demonstrated excellent internal consistency (α = .93) for the MQ-J, with significantly higher scores in the misophonia group compared with the control group. Furthermore, significant positive correlations were observed with sensory processing problems, obsessive-compulsive tendencies, anxiety, depressive symptoms, and difficulties in daily life. These findings supported the validity and reliability of the MQ-J. Hence, the MQ-J was a valuable tool for assessing misophonia symptoms in Japanese adults.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 133-139"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of bilateral high-definition γ-tACS on negative symptoms and mismatch negativity in schizophrenia","authors":"Wen Liu ,&nbsp;Li Wan ,&nbsp;Yaqun Chen ,&nbsp;Longcai Fei ,&nbsp;Huanzhong Liu","doi":"10.1016/j.jpsychires.2025.05.056","DOIUrl":"10.1016/j.jpsychires.2025.05.056","url":null,"abstract":"<div><h3>Background</h3><div>At present, there is a lack of good treatment methods for the negative symptoms of schizophrenia. Previous studies have suggested that high-definition transcranial alternating current stimulation (HD tACS) in the dorsolateral prefrontal cortex (DLPFC) can significantly improve negative symptoms and that γ oscillation may also be effective for treating negative symptoms. The aim of our study was to investigate the therapeutic effect of HD γ-tACS on the negative symptoms of schizophrenia. Active auditory mismatch negativity (MMN) was introduced as neurobiological evidence to verify the intervention effect of tACS on schizophrenia.</div></div><div><h3>Methods</h3><div>A total of 53 patients with schizophrenia mainly with negative symptoms were enrolled in our study. Twenty-seven patients were divided into a real group, which was based on 60 Hz stimulation, 15 min on the unilateral side, for 10 consecutive working days, and 26 patients were divided into a sham group to receive tACS intervention. At baseline and after the intervention, the clinical and behavior scale measurements and EEG data collection under the active auditory oddball paradigm were performed in the two groups, and the differences between the two groups were compared and analysed.</div></div><div><h3>Results</h3><div>1. At baseline, there was no significant difference in the active MMN (MMN/P3a complex) amplitude between the two groups. 2. After tACS intervention, the active MMN amplitudes of the Fz, FCz, Cz, CPz and Pz channels in the central frontoparietal lobe of the real tACS group increased significantly. 3. Negative symptoms were significantly reduced in the real tACS group positive and negative syndrome scale (PANSS) negative symptom subscale score. 4. Regression analysis revealed that in the Fz channel, the change in MMN was moderately positively correlated with the reduction in negative symptom scores.</div></div><div><h3>Conclusion</h3><div>γ-tACS in the bilateral dlPFC can significantly improve the negative symptoms of patients with schizophrenia, and the amplitude of active MMN in the frontoparietal region is significantly increased after intervention. To some extent, the greater the improvement in active MMN after intervention compared with baseline, the more obvious the improvement in clinical negative symptoms. This study provides a reference for tACS therapy to improve negative symptoms in patients with schizophrenia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 43-51"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calls with suicidality and psychological distress to a national helpline during the COVID-19 pandemic","authors":"Shiri Daniels ,&nbsp;Hadas Yeshayahu ,&nbsp;Gil Zalsman ,&nbsp;Sahar Yihia ,&nbsp;Ella Sarel-Mahlev ,&nbsp;Joy Benatov","doi":"10.1016/j.jpsychires.2025.05.054","DOIUrl":"10.1016/j.jpsychires.2025.05.054","url":null,"abstract":"<div><div>This study examines the psychological distress and suicide-related calls to Israel's national crisis helpline (ERAN) in the aftermath of the COVID-19 pandemic, evaluating the impact of COVID-19 public health measures, including lockdowns and vaccination rollouts. The analysis, covering over a million calls, investigating trends in call volume associated with policy shifts. Findings indicate an initial peak in distress calls, which gradually declined, stabilizing after vaccines became available. Suicide-related calls increased at a slower rate and later dropped, following vaccine rollout. Lockdowns were correlated with heightened general distress, but not with an increase in suicide-related calls.</div><div>The findings highlight the importance of continuous monitoring and support for populations at risk of suicide, as suicidal tendencies can emerge gradually, lagging after the emotional distress. These results underscore the critical role of public health measures in mitigating mental health outcomes during national health crises, potentially offering policymakers valuable insights for future pandemic response planning.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 57-63"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-related suicidal ideation in the K-12 population: a real-world pharmacovigilance study of the FDA adverse event reporting system (FAERS) database","authors":"Yaxin Ju ,&nbsp;Yuan Liu ,&nbsp;Li Tan ,&nbsp;Li Su","doi":"10.1016/j.jpsychires.2025.05.029","DOIUrl":"10.1016/j.jpsychires.2025.05.029","url":null,"abstract":"<div><h3>Objective</h3><div>The K-12 population refers to individuals, primarily aged 6–17, from kindergarten through 12th grade. Drug-related suicidal ideation (SI) in the K-12 population is a major concern. This study aims to identify medications linked to increased SI risk in the K-12 population using the FDA Adverse Event Reporting System (FAERS) database.</div></div><div><h3>Methods</h3><div>We extracted cases of SI in individuals aged 6–17 years where medications were the primary suspect (PS) from the FAERS database, spanning from the first quarter of 2004 to the third quarter of 2023. We conducted descriptive analysis, disproportionality analysis, and subgroup analysis.</div></div><div><h3>Results</h3><div>Our analysis included 4,779 valid cases; 52.75 % were male and 45.66 % were female. The predominant age group was 15–17 years, accounting for 43.92 % of cases. The peak year for case reports was 2019. Montelukast was the most common drug. The four most common indications included attention deficit hyperactivity disorder, depression, acne, and asthma. Disproportionality analysis highlighted 21 drugs as potentially associated with increased SI risk, with esketamine displaying the highest signal (Reporting Odds Ratio, ROR = 103.49). Subgroup analysis identified eleven drugs with elevated risk signals in both genders. Montelukast presented the highest signal in males (ROR = 12.64), and esketamine in females (ROR = 129.50). Cumulatively, the incidence of SI within 90 and 360 days was 51.6 % and 76.9 % in males, and 58.8 % and 85.3 % in females, respectively.</div></div><div><h3>Conclusion</h3><div>This study provides evidence of potential SI risk associated with specific medications in the K-12 population. Further research is necessary to confirm these findings.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 1-9"},"PeriodicalIF":3.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weather's influence on the number of emergency psychiatric visits: myth or reality? A systematic review of the literature","authors":"Marion N’Diambourila ,&nbsp;Pierre Alexis Geoffroy ,&nbsp;Marine Ambar Akkaoui","doi":"10.1016/j.jpsychires.2025.05.025","DOIUrl":"10.1016/j.jpsychires.2025.05.025","url":null,"abstract":"<div><h3>Background</h3><div>The influence of weather on emergency psychiatric visits has been explored in various studies, yet the results have been inconsistent. This systematic review aims to investigate the relationship between meteorological factors and visits to psychiatric emergency departments (ED).</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, this review aimed to clarify the relationship between meteorological factors and psychiatric emergency visits. A systematic literature search was conducted using the PubMed, Cochrane Library, and PsycINFO databases up until January 2024. The search focused on identifying studies that examined ED visits for psychiatric reasons and investigated the impact of at least one meteorological factor (including temperature, atmospheric pressure, precipitation, wind, humidity, sunlight exposure, or day length).</div></div><div><h3>Results</h3><div>Of the 191 articles initially screened, 16 were selected for in-depth analysis. Among these, 10 studies found a significant association between higher temperatures and an increase in psychiatric ED visits. Further subgroup analyses revealed a specific correlation between increased temperature and psychiatric ED visits for mood disorders, psychotic disorders, substance use disorders, suicidal behavior, and anxiety disorders. Research on meteorological factors beyond temperature was notably scarce.</div></div><div><h3>Conclusions</h3><div>The link between increased temperature and psychiatric emergencies could stem from various biological mechanisms, including the modulation of melatonin and serotonin levels. Gaining insights into how weather conditions affect psychiatric ED visits enables a deeper understanding of the triggers for psychiatric decompensations. This information is crucial for developing targeted preventive strategies and informing public health policies aimed at mitigating the impact of adverse weather on mental health crises.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 277-290"},"PeriodicalIF":3.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced abortion and implications for long-term mental health: a cohort study of 1.2 million pregnancies","authors":"Nathalie Auger ,&nbsp;Jessica Healy-Profitós ,&nbsp;Aimina Ayoub ,&nbsp;Antoine Lewin ,&nbsp;Nancy Low","doi":"10.1016/j.jpsychires.2025.05.031","DOIUrl":"10.1016/j.jpsychires.2025.05.031","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between induced abortion and long-term mental health is not clear. We assessed whether having an induced abortion was associated with an increase in the long-term risk of mental health hospitalization.</div></div><div><h3>Methods</h3><div>We carried out a retrospective cohort study of 28,721 induced abortions and 1,228,807 births in hospitals of Quebec, Canada, between 2006 and 2022. The exposure was induced abortion compared with other pregnancies, and the outcome was hospitalization for a psychiatric disorder, substance use disorder, or suicide attempt over time. We followed patients up to 17 years after the end of pregnancy to identify mental health-related hospitalizations. We calculated hazard ratios (HR) and 95 % confidence intervals (CI) for the association between induced abortion and mental health hospitalization, adjusted for pregnancy characteristics.</div></div><div><h3>Results</h3><div>Rates of mental health-related hospitalization were higher following induced abortions than other pregnancies (104.0 vs. 42.0 per 10,000 person-years). Abortion was associated with hospitalization for psychiatric disorders (HR 1.81, 95 % CI 1.72–1.90), substance use disorders (HR 2.57, 95 % CI 2.41–2.75), and suicide attempts (HR 2.16, 95 % CI 1.91–2.43) compared with other pregnancies. The associations were greater for patients who had preexisting mental illness or were aged less than 25 years at the time of the abortion. Abortion was strongly associated with mental health hospitalization within five years but risks waned over time.</div></div><div><h3>Conclusion</h3><div>Induced abortion is associated with an increased risk of mental health-related hospitalization in the long term but the association weakens with time.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 304-310"},"PeriodicalIF":3.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disorders are associated with subsequent depression and anxiety disorders in children and adolescents in Germany-a retrospective cohort study","authors":"Karel Kostev ,&nbsp;Nimran Kaur ,&nbsp;Céline Vetter ,&nbsp;Marcel Konrad","doi":"10.1016/j.jpsychires.2025.05.030","DOIUrl":"10.1016/j.jpsychires.2025.05.030","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to investigate the longitudinal association between sleep disorders and the subsequent development of depression and anxiety disorders in children and adolescents sleep disorders and subsequent depression in children and adolescents.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used electronic medical records from the IQVIA™ Disease Analyzer database and included children and adolescents aged 6–17 years with an initial diagnosis of a sleep disorder and without sleep disorders treated by one of 258 office-based pediatricians between January 2010 and December 2023. The five-year cumulative incidence of depression and anxiety disorders in the cohorts with and without sleep disorders was studied with Kaplan-Meier curves. Multivariable Cox regression analyses were used to assess the association between sleep disorders and depression.</div></div><div><h3>Results</h3><div>The present study included 11,783 children and adolescents with and 58,915 without sleep disorder diagnosis (mean age 10 ± 4 years, 47 % female). Within five years after the index date, 5.3 % of sleep disorder patients and 2.4 % of the matched non-sleep disorder cohort had been diagnosed with depression, and 6.2 % vs. 2.9 % with anxiety disorders. A strong and significant association was observed between sleep disorders and subsequent depression (HR: 2.16; 95 % CI: 1.94–2.39) and anxiety disorder (HR: 2.98; 95 % CI: 1.88–2.30). Upon the exclusion of depression and anxiety disorder diagnoses in the first year after the index date, the association between sleep disorders and both depression (HR: 1.86; 95 % CI: 1.64–2.10) and anxiety disorders (HR: 1.79; 95 % CI: 1.59–2.03) remained strong and significant.</div></div><div><h3>Conclusion</h3><div>The study indicates a strong and significant association between sleep disorders and depression and anxiety disorders in children and adolescents.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 299-303"},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network meta-analysis of the effects of long-term non-pharmacologic treatment on inhibitory control in children and adolescents with attention deficit hyperactivity disorder","authors":"Jingyi Zhou ,&nbsp;Wen Jiang ,&nbsp;Jingwen Wang ,&nbsp;Jingjing Dou","doi":"10.1016/j.jpsychires.2025.05.028","DOIUrl":"10.1016/j.jpsychires.2025.05.028","url":null,"abstract":"<div><h3>Objective</h3><div>To conduct a network meta-analysis comparing the effects of various long-term non-pharmacological treatments on inhibitory control in children and adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) to provide theoretical support for non-pharmacological interventions in ADHD management.</div></div><div><h3>Methods</h3><div>Randomized controlled trials (RCTs) on the effects of long-term non-pharmacological treatments on inhibitory control in children and adolescents with ADHD published up to November 11, 2024, were searched in databases such as CNKI, Web of Science, APA PsycInfo, Embase, PubMed and Cochrane Library.</div></div><div><h3>Results</h3><div>A total of 42 studies, including seven non-pharmacological types, were included, involving 1981 children and adolescents with ADHD, with a mean age of 10.04 ± 1.82 years. Both traditional and network meta-analyses based on post-test data revealed that physical exercise, cognitive training, behavior therapy, and neurofeedback significantly improved inhibitory control (P &lt; 0.05), with physical exercise showing the best improvement (SUCRA: 85.9 %). At the same time, board games, EMG feedback, and meditation had no significant effect (P &gt; 0.05). Follow-up analysis showed that behavior therapy and cognitive training had a good maintenance effect (P &lt; 0.05), with behavior therapy demonstrating the best sustained effect (SUCRA: 95.1 %). In contrast, physical exercise, board games, and neurofeedback showed diminishing effects over time and had no significant long-term effect (P &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Existing evidence shows that physical exercise, cognitive training, behavior therapy, and neurofeedback all have a positive effect on improving inhibitory control in children and adolescents with ADHD, with physical exercise showing the best effect, though with poor maintenance, while cognitive training and behavior therapy had a slightly lower effect, but their maintenance was better.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 261-276"},"PeriodicalIF":3.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying subgroups of adverse childhood experiences (ACEs) in adult general hospital attendees: associations with mental and physical health measures","authors":"Rob Saunders ,&nbsp;Tobias Nolte ,&nbsp;Tom G. Osborn ,&nbsp;Henry Delamain ,&nbsp;David Riedl ,&nbsp;Peter Fonagy ,&nbsp;Astrid Lampe","doi":"10.1016/j.jpsychires.2025.05.024","DOIUrl":"10.1016/j.jpsychires.2025.05.024","url":null,"abstract":"<div><h3>Background</h3><div>Adverse childhood experiences (ACEs) are linked to negative mental and physical health outcomes. While increased ACE exposure often correlates with worse health outcomes, specific combinations of ACEs may heighten the risk for certain conditions and diseases.</div></div><div><h3>Method</h3><div>Participants (n = 2642) attending inpatient and outpatient departments at an Austrian university hospital provided self-reported measures of physical and mental health, along with retrospective assessments of ACEs. Latent class analysis was utilized to identify subgroups of individuals with co-occurring ACEs. Logistic regression models were employed to investigate the associations between ACE clusters and the prevalence of physical and mental health conditions.</div></div><div><h3>Results</h3><div>Six classes were identified, with the majority of individuals falling into the ‘minimal ACEs’ class. However, other groups reported specific ACEs such as ‘peer-bullying’, ‘home-neglect’, and ‘physical abuse’, while two groups experienced a variety of ACEs (‘parent abuse and neglect’ and ‘parental and peer bullying’). Classes were differentially associated with the likelihood of reporting specific mental and physical conditions, with higher odds ratios observed in groups endorsing higher ACEs.</div></div><div><h3>Conclusions</h3><div>This exploratory analysis found that different ACE constellations were associated with varying risks of specific mental and physical health conditions. Identifying individuals within particular ACE clusters could help inform preventive strategies and improve adult health outcomes.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 291-298"},"PeriodicalIF":3.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}