Journal of psychiatric research最新文献

{"title":"Associations between momentary mental states and concurrent social functioning after remission from first episode psychosis: A HAMLETT ecological momentary assessment study.","authors":"Matej Djordjevic, Hannah E Jongsma, Claudia J P Simons, Priscilla P Oomen, Lieuwe de Haan, Nynke Boonstra, Martijn Kikkert, Sanne Koops, Chris N W Geraets, Marieke J H Begemann, Machteld Marcelis, Wim Veling","doi":"10.1016/j.jpsychires.2024.12.002","DOIUrl":"10.1016/j.jpsychires.2024.12.002","url":null,"abstract":"<p><strong>Background: </strong>Symptom severity and social functioning are important outcomes after first episode psychosis (FEP), yet current evidence about associations between them is inconsistent and lacks (subclinical) momentary insights.</p><p><strong>Methods: </strong>The current Ecological Momentary Assessment (EMA) study was conducted in 58 people in remission from FEP, as part of the HAMLETT (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment) trial. At baseline, participants were prompted to report momentary mental states and social context 10x/day for eight consecutive days, including psychotic experiences (PEs), motivation/drive and negative affect, that may indicate proxies of (subclinical) psychotic, negative and general affective symptoms, respectively. We employed multilevel mixed-effects regressions to investigate associations between self-reported mental states and concurrent activity or social company and subjective appraisal thereof. We also conducted retrospective clinical assessments of symptoms (PANSS) and social functioning (WHODAS 2.0) and investigated their cross-sectional associations using multivariable linear regression.</p><p><strong>Results: </strong>Analyses of 3101 EMA-questionnaires showed that lower motivation/drive was associated with more passive activity and less company (OR = 0.96 [95%CI: 0.96; 0.97], OR = 0.95 [95%CI: 0.93; 0.96], N.B. ORs per 1-point symptom-score change). PEs and negative affect were associated with more proactive activity (OR = 1.02 [95%CI: 1.00; 1.03], OR = 1.02 [95%CI: 1.01; 1.03]). All three mental state domains were associated with lower activity appraisal overall, though activity-specific associations differed. PEs and negative affect were associated with lower company appraisal (B = -0.25 [95%CI: -0.36; -0.14], B = -0.15 [95%CI: -0.23; -0.06]). When assessed retrospectively, only PANSS general psychopathology was associated with poorer social functioning (B = 2.52 [95%CI: 1.69; 3.34]).</p><p><strong>Conclusion: </strong>Self-reported PEs, momentary motivation/drive and general affective symptoms are associated with daily-life functioning after remission from FEP. Retrospective observer-rated and momentary self-report assessment methods do not measure the same aspects or intensity of psychopathology.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"560-569"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decluttering Minds: Psychological interventions for hoarding disorder - A systematic review and meta-analysis.","authors":"Emily O'Brien, Keith R Laws","doi":"10.1016/j.jpsychires.2024.12.029","DOIUrl":"10.1016/j.jpsychires.2024.12.029","url":null,"abstract":"<p><strong>Background: </strong>Cognitive Behavioural Therapy (CBT) is conventionally considered the primary intervention for Hoarding Disorder (HD), yet various psychological interventions have recently emerged. This study, pre-registered at Prospero (CRD42023427534), aims to comprehensively assess a range of psychological interventions, including CBT, for reducing HD symptomatology.</p><p><strong>Methods: </strong>A systematic literature search using PubMed and SCOPUS identified 41 eligible studies comprising 47 samples (N = 1343). Risk of bias for RCTs was assessed using the Cochrane RoB2 tool, and methodological quality for all studies was evaluated using the Psychotherapy Outcome Study Methodology Rating Form (POMRF).</p><p><strong>Results: </strong>Pre-post effects revealed a large reduction in HD symptomatology (g = -1.09), sustained at follow-up in 18 studies (g = -1.12, N = 588). Additionally, 8 Randomized Controlled Trials (RCTs) demonstrated a substantial end-of-trial reduction in HD symptoms compared to controls (g = -0.75). Meta-regression found no moderating effects for: demographics, medication use, number of treatment sessions, or study quality. Similarly, no differences were observed between group and individual therapy, therapy with or without home visits, or CBT versus other psychological interventions.</p><p><strong>Conclusion: </strong>This study confirms psychological therapies are effective in reducing hoarding symptoms, while indicating no superiority for CBT. Despite the benefits, symptoms often persist above the clinical cut-off for HD, highlighting the enduring clinical challenges in achieving symptomatic remission. The findings underscore the need to address methodological limitations and possible age and gender bias in future research to enhance the efficacy and inclusivity of psychological interventions for HD.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"738-751"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct white matter abnormalities and cognitive impairments in deficit schizophrenia: A cross-sectional diffusion tensor imaging study.","authors":"Ju Gao, Doudou Yu, Ming Yin, Jin Li, Xiaobin Zhang, Xiaowei Tang, Xiangrong Zhang","doi":"10.1016/j.jpsychires.2024.11.054","DOIUrl":"10.1016/j.jpsychires.2024.11.054","url":null,"abstract":"<p><p>Deficit schizophrenia (DS), characterized by persistent and primary negative symptoms, is considered a promising homogeneous subtype of schizophrenia. According to the disconnection hypothesis, abnormalities in white matter fibers are common in schizophrenia. However, comprehensive measurement of white matter metrics and exploration of the relationships between neuroanatomical changes and cognitive functions in DS patients are still unknown. A cross-sectional study was conducted, including 35 DS patients, 37 non-deficit schizophrenia (NDS) patients, and 39 healthy controls (HC), all male and matched for age and education level. The tract-based spatial statistics method was performed to detect differences in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) among these three groups. Cognitive function in DS and NDS patients was assessed using the Mini-Mental State Examination (MMSE) and Mattis Dementia Rating Scale. Correlation analyses were performed between diffusion metrics in regions showing differences and clinical scales. The results showed significant differences in diffusion metrics (FA, RD, AD, MD) across DS, NDS, and HC groups, particularly in the corpus callosum, corona radiata, and thalamic radiations. Compare to NDS, DS patients exhibited more reductions in FA and increases in RD, especially in the right posterior thalamic radiation and right superior longitudinal fasciculus. Correlation analysis revealed that lower FA in specific regions was linked to worse cognitive and clinical symptoms. These findings reinforce the dysconnectivity hypothesis of schizophrenia and highlight the distinct pathological mechanisms of white matter impairments in DS. Correlations in crucial white matter regions suggest disruptions in thalamo-cortical feedback loops, potentially contributing to the cognitive impairments observed. This provides a deeper understanding of how structural brain changes relate to clinical symptoms.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"381-390"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the response to antipsychotics or mood stabilizers in patients with acute mania: An individual patient data meta-analysis of placebo-controlled studies.","authors":"Bram W C Storosum, Sem E Cohen, Taina K Mattila, Kit C B Roes, Carlijn Welten, Wim van den Brink, Lieuwe de Haan, Damiaan Denys, Jasper B Zantvoord","doi":"10.1016/j.jpsychires.2024.11.014","DOIUrl":"10.1016/j.jpsychires.2024.11.014","url":null,"abstract":"<p><p>Evidence suggests a worse clinical course in women compared to men with bipolar disorder. However, little research has explored gender differences in the efficacy of anti-manic medication. We sought to determine whether there are gender differences in efficacy of drug treatment in acute manic episodes of bipolar I disorder, and the influence of dichotomized age as a proxy for menopausal status and baseline severity on gender differences. We performed an individual patient data meta-analysis of 10 short term placebo controlled registration trials for treatment of acute mania (N = 2199) performed between 1996 and 2007 using the (Young) Mania Rating Scale ((Y)MRS)) as outcome. We observed a difference in effect size in mean change and responder status between men and women (NNT = 6.3 vs. 5.3), with a small but significant effect of gender on treatment response (β = 0.031). The effect size was larger in women older than 47 compared to women aged 47 and under (NNT = 4.2 vs. 7.5), and to a lesser extent, larger in men over 47 years compared those aged 47 and under (NNT = 3.8 vs. 6). Results were mainly driven by differences in response in the placebo group and independent of baseline severity. These findings suggest that men and premenopausal women might have a clinically modest advantage over their women and postmenopausal counterparts in treatment with anti-manic medication. Our results were limited by our sample not including antimanic agents registered after 2007 and by the absence of direct biological information regarding sex and menopausal state. Future research should aim to replicate current findings utilizing biological confirmation on the menopausal status and test whether findings are generalizable to newer antimanic agents.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"358-364"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online disclosure of suicide method: What can online posts tell us about suicidal planning?","authors":"Brooke A Ammerman, Kenneth McClure, Keyne C Law, Caitlin M O'Loughlin, Ross Jacobucci","doi":"10.1016/j.jpsychires.2024.11.048","DOIUrl":"10.1016/j.jpsychires.2024.11.048","url":null,"abstract":"<p><p>Rates of self-disclosure of, and subsequently formal help-seeking for, suicidal thoughts and behaviors (STBs) remains low. However, online discussions of STBs have become increasingly prevalent, creating potential opportunities to identify those at potentially elevated suicide risk (i.e., engaging in suicidal planning). This study used linguistic analysis to examine online STB discussions to identify posts that reference a suicide method, as well as the lethality and timeframe of the identified suicide method. A corpus of 3974 posts from the online forum Reddit SuicideWatch were extracted for data analysis. Approximately one-fifth of analyzed posts mentioned a suicide method; over 35% were classified as severe risk with regard to lethality and almost 70% discussed a suicide method yet to occur. Analyses demonstrated that three categories of words - Substances, Physical, and Past Focus - were associated with increased odds of the presence of a suicide method in a post, whereas five different word categories were associated with a decrease in odds of method presence; most notably was the use of Social words. Together, results support the utility of this approach in detecting discussions of a suicide method. However, they may be less fruitful in distinguishing planning severity among posts including method discussions.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"503-508"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the dynamics and causality of PTSD symptoms in firefighters: Insights from cross-lagged panel network analyses.","authors":"Zhongying Wu, Bin Liu, Qiannan Jia, Yuting Feng, Zhujing Ma, Huiling Yuan, Yidi Wang, Yinchuan Jin, Lei Song, Mengze Li, Hongyi Chen, Meng Wei, Lei Ren, Qun Yang","doi":"10.1016/j.jpsychires.2024.12.028","DOIUrl":"10.1016/j.jpsychires.2024.12.028","url":null,"abstract":"<p><p>Firefighters have a greater prevalence of posttraumatic stress disorder (PTSD) because of their greater risk of exposure to traumatic events. Network analysis offers novel perspectives for understanding PTSD. However, most previous network analysis studies were cross-sectional and failed to reveal the dynamics and causality of PTSD symptoms. Therefore, this study aimed to elucidate the longitudinal development of and causal relationships among PTSD symptoms in firefighters. Two survey waves were conducted among 637 Chinese male firefighters: in April 2021 (baseline) and March 2023 (follow-up). We constructed two cross-sectional networks and one longitudinal cross-lagged panel network (CLPN) of PTSD symptoms. By comparing the two cross-sectional networks, we found that the central symptoms of PTSD changed over time, with central symptoms scattered across different dimensions at baseline and focused on the avoidance dimension at follow-up. The CLPN revealed causal relationships among PTSD symptoms and showed that irritability and nightmares significantly predicted other PTSD symptoms from baseline to follow-up. In summary, our study fills a gap in the longitudinal development of and causal relationships among PTSD symptoms in firefighters and provides potential targets for subsequent prevention and intervention.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"673-680"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial expression analysis using convolutional neural network for drug-naive and chronic schizophrenia.","authors":"Tongxin Li, Xiaofei Zhang, Conghui Wang, Tian Tian, Jinghui Chi, Min Zeng, Xiao Zhang, Lili Wang, Shen Li","doi":"10.1016/j.jpsychires.2024.11.065","DOIUrl":"10.1016/j.jpsychires.2024.11.065","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Facial images have been shown to convey mental conditions as clinical symptoms. This study aimed to use facial images to detect patients with drug-naive schizophrenia (DN-SCZ) or chronic schizophrenia (C-SCZ) from healthy controls (HCs), and to investigate differences in facial expressions among these 3 groups, as well as relationships between facial expressions and psychiatric symptoms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We recruited 45 DN-SCZ patients, 106 C-SCZ patients and 101 HCs for the study, and videotaped their facial expressions through a fixed experimental paradigm. The video data was converted to facial images and divided into two sets: one for training a group classification-convolutional neural network (CNN) with the classification of DN-SCZ patient, C-SCZ patient and HC as output, and the other for evaluating classification results of the group classification-CNN. Subsequently, we extracted and evaluated 300 labeled facial images for each basic facial expression. These labeled images were employed to train separate facial expression-CNNs for each group (DN-SCZ, C-SCZ, and HCs). All facial images from the videos were then processed by their facial expression-CNNs to output the most probable facial expressions. The psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale. Statistical analyses were conducted on the predicted facial expressions to identify differences among the groups, and to examine relationships between the predicted facial expressions and the clinical data of DN/C-SCZ patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The group classification-CNN achieved an accuracy of 90.99% in correctly classifying participants based on facial images. The 3 facial expression-CNNs achieved accuracies of 95.95%, 87.23%, and 92.11% in predicting 8 basic facial expressions within the 3 groups. Facial images of HCs were rated higher in valence, arousal and attractiveness, but lower in deviation from normal face than those of DN/C-SCZ patients. Happy images of DN-SCZ patients were rated lower in valence and arousal than those of C-SCZ patients, while their angry images were rated higher in arousal, attractiveness and deviation from normal images than those of C-SCZ patients. Within the fixed experimental paradigm, DN-SCZ patients exhibited sadder, more surprised expressions, while displaying fewer happy, angry and disgusted expressions, statistical metrics of their fearful and angry expressions were correlated with their total positive symptom score and total general psychopathology score, respectively. C-SCZ patients exhibited happier, more content, angry and neutral expressions, while showing fewer surprised expressions, no significant relationships were observed between their facial expressions and clinical data.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Facial expressions can potentially serve as indicative signs for detecting DN-SCZ and C-SCZ patients. There are objective differences in certai","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"225-236"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Hearing loss and depression - Comprehensive community support.","authors":"Ying Cui","doi":"10.1016/j.jpsychires.2024.11.035","DOIUrl":"10.1016/j.jpsychires.2024.11.035","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"330-332"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADHD and alcohol: Emotional regulation efforts pay off in quality of life points.","authors":"Amandine Luquiens, Thibault Mura, Alexandra Dereux, Patrice Louville, Hélène Donnadieu, Marie Bronnec, Amine Benyamina, Pascal Perney, Arnaud Carré","doi":"10.1016/j.jpsychires.2024.12.012","DOIUrl":"10.1016/j.jpsychires.2024.12.012","url":null,"abstract":"<p><p>The emotion dysregulation and impulsivity are highly associated with alcohol use disorder (AUD). This study explored the role of impulsivity and emotion dysregulation and the interaction with adult probable ADHD on alcohol-related quality of life (QoL). In this observational trial, we analyzed data from the randomized TRAIN study, which compared efficacy of two cognitive training programs in patients AUD recently detoxified at 5 centers in France from February 2019 to February 2023, and who completed child and adult ADHD screening data (WURS + ARSR, n = 206 of 226). We collected baseline data on AUD severity, age, sex, quality of life (AQoLS), cognitive impairment (MoCA), impulsive behavior (UPPS-P) and emotion dysregulation (ERQ expressive suppression subscore, DERS-impulse). Patients with probable and without ADHD were compared. We performed multiple linear regression explaining the total AQoLS score (dependent variable) by impulsivity (UPPS-P score), emotion regulation (DERS-impulse), and expressive suppression (ERQ expressive suppression subscore), and their interaction with ADHD, adjusted on MoCA, sex, age. Forty (19%) patients were above the screening threshold for ADHD. The impact of alcohol on QoL was greater in them than in those without ADHD (57.3 (21.9) vs. 46.4 (19.6), p = 0.002). High impulsivity and emotion dysregulation dimensions were both significantly associated with poorer QoL. ADHD interacted significantly with expressive suppression to worsen the impact of alcohol on QoL (p = 0.04). The dysfunctional attempts to compensate for the strong dysregulation of emotions in ADHD lowers QoL in AUD.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"463-469"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal neurofunctional alterations following nonpharmacological treatments and the mediating role of regional homogeneity in subclinical depression comorbid with sleep disorders among college students.","authors":"Xinyu Liang, Hanyue Zhang, Xiaotong Wang, Danian Li, Yujie Liu, Shijun Qiu","doi":"10.1016/j.jpsychires.2024.12.038","DOIUrl":"10.1016/j.jpsychires.2024.12.038","url":null,"abstract":"<p><strong>Background: </strong>Clinical guidelines recommend nonpharmacological treatment (nPHT) as the primary intervention for subthreshold depression management. Counseling (CS) and electroacupuncture (EA) are two promising nonpharmacological approaches for improving both depression and sleep disturbance. However, the intrinsic neuroimaging mechanisms underlying the antidepressant effects of these nPHTs are not yet fully understood.</p><p><strong>Methods: </strong>We analyzed longitudinal resting-state functional magnetic resonance imaging (rs-fMRI) data from a randomized, single-blind clinical trial involving 96 first-episode, drug-naïve college students with subclinical depression and sleep disorders (sDSD; mean age 20.43 ± 2.72 years; 66.7% female) and 90 healthy controls (HCs; mean age 21.02 ± 2.68 years; 61.1% female). Participants with sDSD were randomly assigned to receive either scalp EA (n = 47) or CS (n = 49) for six weeks. The regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) before and after nPHT were calculated. Correlation and mediation analyses were performed to investigate the complex relationships between fMRI indicators and clinical symptoms.</p><p><strong>Results: </strong>The ALFF in the left paracentral lobule in sDSD patients presented an interaction effect between group and time following six weeks of nPHT. In the CS group, the ALFF in the left paracentral lobule decreased (p < 0.001), and in the EA group, it increased (p < 0.05). Compared with HCs, the baseline sDSD has many abnormal brain regions in terms of ALFF and ReHo. The whole-brain average ReHo was negatively correlated with depression scores (r = -0.26, p < 0.001) and sleep quality scores (r = -0.25, p < 0.001) and mediated the association between depression and sleep disorders [β = 0.2857, p < 0.001, 95% CI (0.23, 0.35)].</p><p><strong>Conclusions: </strong>Nonpharmacological therapies provide different therapeutic outcomes in terms of the same rs-fMRI indicator. ALFF in the left paracentral lobule could be used as an imaging biomarker in nPHT selection. Rs-fMRI indicators are promising for understanding the neural basis of the complex relationship between subclinical depression and insomnia comorbidities in young adults.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"663-672"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}