Journal of psychiatric research最新文献

{"title":"The effects of psychedelic-assisted therapy on illness and death anxiety: A systematic review and meta-analysis","authors":"Aron Amaev ,&nbsp;Jianmeng Song ,&nbsp;Yasaman Kambari ,&nbsp;Edgardo Carmona-Torres ,&nbsp;Ali Abdolizadeh ,&nbsp;Fumihiko Ueno ,&nbsp;Teruki Koizumi ,&nbsp;Antonio P. Strafella ,&nbsp;M. Ishrat Husain ,&nbsp;Ariel Graff-Guerrero ,&nbsp;Philip Gerretsen","doi":"10.1016/j.jpsychires.2025.03.022","DOIUrl":"10.1016/j.jpsychires.2025.03.022","url":null,"abstract":"<div><div>Illness anxiety (IA) is characterized by worry or fear in response to living with a chronic illness or a preoccupation with having or acquiring a serious disease in conjunction with absent to mild somatic symptomatology. Death anxiety (DA) may underpin IA and is more common in individuals with life-threatening illness. Treatments for DA and IA, such as psychotherapy and antidepressant drugs, are limited. Serotonergic psychedelic assisted therapy (PT) is a promising treatment alternative as it acts more rapidly than antidepressants and has been shown to decrease anxiety associated with life-threatening illness. This meta-analysis aims to systematically analyze PTs efficacy for DA and IA. A literature search of English language publications was conducted through the Ovid database using Medline®, PsychINFO®, and Embase® from date of inception to February 2024. Validated measures were available to assess DA. However, the State Trait Anxiety Inventory (STAI) was the only measure consistently available across studies to assess anxiety. Given the STAI State scale assesses transient anxiety, which may occur as a result of stressful circumstances, we employed it as a measure of anxiety in the context of a life-threatening illness. Five randomized controlled trials were included. The results showed that PT was associated with sustained decreases in DA and State and Trait anxiety in the context of having a life-threatening illness. This meta-analysis highlights PT as a treatment for DA and anxiety in the context of a life-threatening illness. Future studies should attempt to replicate these findings in other contexts, such as IA Disorder and somatic symptom disorders.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 204-214"},"PeriodicalIF":3.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The change of inflammatory cytokines after antidepressant treatment and correlation with depressive symptoms","authors":"Manle Yin ,&nbsp;Heng Zhou ,&nbsp;Jin Li ,&nbsp;Lianzi Wang ,&nbsp;Ming Zhu ,&nbsp;Ning Wang ,&nbsp;Ping Yang ,&nbsp;Zhongming Yang","doi":"10.1016/j.jpsychires.2025.02.062","DOIUrl":"10.1016/j.jpsychires.2025.02.062","url":null,"abstract":"<div><h3>Background</h3><div>The objective of this study was to explore the serum levels of IL-1, IL-6, IL-10, TNF-a, and high-sensitivity C-reactive protein (hs-CRP) in patients with depression before and after treatment and their correlation with the clinical symptoms of depression.</div></div><div><h3>Methods</h3><div>Fifty depression patients newly diagnosed and untreated in the Fourth People's Hospital of Wuhu were chosen as the depression group, while 50 healthy individuals from the same period served as the control group. We contrasted the serum levels of these markers of inflammation in both groups. After 8 weeks of SSRI antidepressant therapy, changes in inflammatory cytokines, hs-CRP, and HAMD-17 scores were evaluated in the depression group.</div></div><div><h3>Results</h3><div>The levels of serum inflammatory cytokines and hs-CRP in patients with depression were higher than the healthy control group significantly (P &lt; 0.05). After treatment, the levels of serum inflammatory cytokines and hs-CRP in patients with depression decreased significantly (P &lt; 0.05). The total score of HAMD-17 and the scores of sleep, cognitive impairment, inhibition, and anxiety somatization factors in the depression group were decreased than those before treatment (P &lt; 0.01). The serum IL-1 concentration in the depression group inversely related to the decrease in the HAMD-17 inhibition factor (R = −0.359,P = 0.011); The serum IL-6 concentration change rate positively correlated with the reduction rate of the cognitive impairment factor of HAMD-17 (R = 0.426,P = 0.017); the change rate of hs-CRP concentration was positively correlated with the reduction rate of the anxiety somatization factor of HAMD-17 (R = 0.343,P = 0.015).</div></div><div><h3>Conclusion</h3><div>Antidepressant treatment affects the levels of serum inflammatory cytokines and hs-CRP significantly, and is correlated with changes in clinical symptoms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 418-423"},"PeriodicalIF":3.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sulforaphane on negative symptoms and cognitive impairments in chronic schizophrenia patients: A randomized double-blind trial","authors":"Haiyu Chen ,&nbsp;Jinjun Lu ,&nbsp;Tianxiang Zou ,&nbsp;Ziwei Teng ,&nbsp;Yue Qin ,&nbsp;Renrong Wu ,&nbsp;Yeliang Yan ,&nbsp;Kai Fu ,&nbsp;Wenjuan Jiang ,&nbsp;Yunxia Ju ,&nbsp;Riyong Zhu ,&nbsp;Jianzhong Mo ,&nbsp;Jian Lu ,&nbsp;Jing Huang","doi":"10.1016/j.jpsychires.2025.03.023","DOIUrl":"10.1016/j.jpsychires.2025.03.023","url":null,"abstract":"<div><h3>Background</h3><div>The pathological mechanisms of negative symptoms and cognitive impairment in schizophrenia may involve oxidative stress and neuroinflammation. Sulforaphane is an organosulfur compound with antioxidant and anti-inflammatory properties. This study aimed to evaluate its efficacy in ameliorating negative symptoms and cognitive impairments in chronic schizophrenia patients.</div></div><div><h3>Method</h3><div>This 24-week double-blind randomised trial (NCT04521868) recruited schizophrenia patients with significant negative symptoms. Participants were randomly assigned to receive either sulforaphane or placebo and were required to complete at least one post-intervention assessment to evaluate changes in negative symptoms and cognitive functioning. Existing antipsychotic medication treatment regimens remained unchanged throughout the study.</div></div><div><h3>Results</h3><div>A total of 42 patients were included in the statistical analysis, with 28 receiving sulforaphane and 14 assigned to placebo. Sulforaphane significantly reduced the Negative Symptom Score from the PANSS 5-Factor model between groups (<em>p</em> = 0.007) and exhibited a significant time-by-group interaction (<em>p</em> = 0.023), with more pronounced group differences observed after 12 weeks compared to 24 weeks of treatment. Sulforaphane also demonstrated a significant reduction in the original PANSS Negative Symptom Score between groups (<em>p</em> = 0.029). However, sulforaphane showed no significant effects on the MATRICS Consensus Cognitive Battery composite score or its subscores.</div></div><div><h3>Conclusion</h3><div>The significant improvements in the Negative Symptom Score from the PANSS 5-Factor model and the original PANSS Negative Symptom Score in the sulforaphane group suggest the potential of sulforaphane as an adjunctive treatment for ameliorating negative symptoms in chronic schizophrenia. Further research is warranted to explore the effects of sulforaphane on cognitive function.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 464-472"},"PeriodicalIF":3.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond rheumatoid arthritis: A meta-analysis of the prevalence of anxiety and depressive disorders in rheumatoid arthritis","authors":"Dalainey H. Drakes ,&nbsp;Emily J. Fawcett ,&nbsp;Justine J.J. Yick ,&nbsp;Ashlee R.L. Coles ,&nbsp;Rowan B. Seim ,&nbsp;Kaitlyn Miller ,&nbsp;Madison S. LaSaga ,&nbsp;Jonathan M. Fawcett","doi":"10.1016/j.jpsychires.2025.03.020","DOIUrl":"10.1016/j.jpsychires.2025.03.020","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of anxiety and depressive disorders in patients with rheumatoid arthritis (RA) is heterogenous with reports from 2.4 % to 85.2 % and 15 %–73.2 %, respectively. The present study provides meta-analytic current, and lifetime estimates of anxiety and depressive disorders amongst those living with RA.</div></div><div><h3>Method</h3><div>An online search of PubMed, PsycINFO, CINAHL, and WoS was conducted. Of the 3801 articles identified, 13 and 22 studies were coded for anxiety or depressive disorder prevalence in RA, respectively. Studies were included if they prospectively examined individuals (age &gt;16) with RA, used semi-structured diagnostic interviews, and reported lifetime or current anxiety or depressive disorder comorbidity.</div></div><div><h3>Results</h3><div>Data were analyzed using a Bayesian multilevel modelling approach, revealing current and lifetime prevalence of anxiety disorders to be 13.5 % CI_{95 %} (9.2–17.3) and 22.2 %, CI_{95 %} (15.9–29.1), respectively. Models also demonstrated the current and lifetime prevalence of depressive disorders to be 17.9 % CI_{95 %} (10.1–27.1) and 32.4 %, CI_{95 %} (18.3–47.6), respectively. Moderator analyses revealed numerically greater rates of GAD and MDD than other anxiety or depressive disorders.</div></div><div><h3>Limitations</h3><div>There were too few estimates to extensively model several moderators or to conduct exhaustive comparisons of demographic populations requiring greater representation such as males, non-White participants, and people with young adult RA onset.</div></div><div><h3>Conclusions</h3><div>The prevalence and risk for comorbid anxiety and depressive disorders in RA is extremely high. Routine screening and ongoing monitoring of individuals with RA for comorbid anxiety and depressive disorders is important to support improved prognosis.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 424-438"},"PeriodicalIF":3.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory verbal hallucinations among intervention seekers with and without complex PTSD: Prevalence and relationship with dissociative symptoms","authors":"Cherry Tin Yan Cheung ,&nbsp;Chak Hei Ocean Huang ,&nbsp;Fulei Geng ,&nbsp;Anson Kai Chun Chau ,&nbsp;Guangzhe Frank Yuan ,&nbsp;Caimeng Liu ,&nbsp;Janet Yuen-Ha Wong ,&nbsp;Hong Wang Fung","doi":"10.1016/j.jpsychires.2025.03.021","DOIUrl":"10.1016/j.jpsychires.2025.03.021","url":null,"abstract":"<div><div>A growing body of research suggests that auditory verbal hallucinations (AVHs) are associated with trauma and dissociation. Little is known about the prevalence of AVHs in people with complex PTSD after the launch of the ICD-11. Moreover, much less is known regarding which specific dissociative symptoms are associated with AVHs. This study described the prevalence of AVHs in a sample of trauma intervention seekers (<em>N</em> = 213) with and without probable complex PTSD and examined the relationship because AVHs and different specific dissociative symptom clusters. Participants completed validated measures of childhood trauma, complex PTSD, dissociation, and AVHs. In participants with probable complex PTSD (<em>n</em> = 165, 77.5 %), 27.9 % reported AVHs, while 15.4 % of participants with probable PTSD reported AVHs. After controlling for complex PTSD symptoms, two specific forms of dissociation (i.e., memory disturbance [β = 0.217, <em>p</em> = .024] and identity dissociation [β = 0.478, <em>p</em> &lt; .001]) were associated with AVHs. This study provides the first data regarding the prevalence of AVHs in individuals with and without probable ICD-11 complex PTSD. Our findings also contribute to the growing literature on the relationship between AVHs and dissociation. AVHs may be better explained by dissociative processes, especially identity dissociation. These findings suggest that AVHs, at least in some cases, could be a manifestation of identity dissociation.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 405-410"},"PeriodicalIF":3.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the psychometric properties of the flexible interview for ICD-11 (FLII-11) among adults in India","authors":"TS Jaisoorya ,&nbsp;Girish N Rao ,&nbsp;Geoffrey M. Reed ,&nbsp;VS Binu ,&nbsp;K Thennarasu ,&nbsp;Dan J. Stein ,&nbsp;Karen T. Maré ,&nbsp;Christine Lochner ,&nbsp;José A. García-Pacheco ,&nbsp;Vivek Benegal","doi":"10.1016/j.jpsychires.2025.03.024","DOIUrl":"10.1016/j.jpsychires.2025.03.024","url":null,"abstract":"<div><div>The Flexible Interview for ICD-11 (FLII-11) is a fully-structured interview for diagnosing mental disorders responsible for most of the global disease burden consistent with the ICD-11 diagnostic requirements, developed via a collaborative international process under the auspices of the World Health Organization (WHO). The FLII-11 (Version 0.2) was developed for use in epidemiological and clinical studies and can be administered by trained lay interviewers. This study at the NIMHANS, Bengaluru, India is the first to examine its psychometric properties. The diagnostic validity and reliability of the FLII-11 was examined by comparing diagnoses made using the FLII-11 administered by lay interviewers with diagnoses made by consultant psychiatrists. A total of 365 patients and 260 controls were assessed. The level of agreement between raters for both patients and controls were assessed using kappa (κ). In addition, the sensitivity, specificity, positive predictive value, and negative predictive value were estimated. The FLII-11 diagnoses showed very good agreement (κ-0.81) with consultant psychiatrist diagnoses and had acceptable values of sensitivity (83.3 %) and specificity (78.8 %) for the diagnoses of any mental disorder. Among the diagnostic categories examined, the psychometric properties of primary psychotic disorder, bipolar disorder, depressive disorder, substance use disorders, anxiety disorders, and obsessive-compulsive and related disorders were adequate, however inferences for diagnostic categories of eating disorders and stress related disorders could not be made as a sufficient sample size was not achieved. The study indicates that the FLII-11 (Version 0.2) has strong psychometric properties in this setting. Future directions include replication to confirm these findings and explore their applicability to diverse settings and other countries.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 439-445"},"PeriodicalIF":3.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality factors associated with manner of death: A psychological autopsy study","authors":"Christopher I. Gurguis ,&nbsp;Scott D. Lane ,&nbsp;Edison Leung ,&nbsp;Joy M. Schmitz ,&nbsp;Consuelo Walss-Bass ,&nbsp;Thomas D. Meyer","doi":"10.1016/j.jpsychires.2025.03.019","DOIUrl":"10.1016/j.jpsychires.2025.03.019","url":null,"abstract":"<div><div>Psychological autopsies are a well-established tool for understanding contributing factors in suicide completion. These tools have been used less often to understand personality characteristics of people with other manners of death (e.g. overdose). This study examined personality characteristics related to the manner of death in 83 autopsy cases using the UTHealth Psychological Autopsy Interview Schedule (UTH-PAIS), a psychological autopsy which assesses the presence of mental illness or substance use disorder but also includes items to capture transdiagnostic personality factors. Exploratory factor analysis of the items assessing personality factors was used to examine patterns in personality, and these factors were confirmed <em>via</em> k-means clustering. This analysis uncovered four distinct personality factors: (1) perseverance and self-regulation, (2) aggression, (3) sensitivity to rejection, and (4) extraversion. Of these personality factors, only perseverance and self-regulation differed by the manner of death. Individuals who died of natural causes or by completed suicide had a higher perseverance and self-regulation factor score than those who died by substance overdose, and these patterns were further supported by cluster analysis. The findings suggest that, in this autopsy sample, suicide was a planned, rather than an impulsive, act, though this interpretation is made cautiously given the sample size which also prohibited analysis of overdose death between those with vs. without a prior suicide attempt. Additionally, the results support prior work suggesting substance use disorders are associated with poor self-regulation, which may contribute to overdose deaths in these individuals. The study demonstrates the utility of psychological autopsy for studying personality factors related to the manner of death in cases where <em>ante mortem</em> data is unavailable.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 522-527"},"PeriodicalIF":3.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-carbohydrate diet macronutrient quality and depression symptoms among US adults","authors":"Chengxiang Hu ,&nbsp;Beibei Han ,&nbsp;Yue He ,&nbsp;Rong Huang ,&nbsp;Xiaoting Fan ,&nbsp;Jia Lan ,&nbsp;Yanan Ma ,&nbsp;Lina Jin","doi":"10.1016/j.jpsychires.2025.03.013","DOIUrl":"10.1016/j.jpsychires.2025.03.013","url":null,"abstract":"<div><h3>Background</h3><div>The association between the quality of low-carbohydrate diets (LCDs) and depression symptoms remains underexplored. This study investigates the effects of LCDs on depression symptoms, with a specific focus on distinguishing the quality and quantity of macronutrients.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 28,791 participants aged ≥20 were involved. Three LCD scores were constructed based the quality and quantity of macronutrients: overall LCDs (OLCDs), healthy LCDs (HLCDs: characterized by reduced intake of low-quality carbohydrates [e.g., refined sugars], higher plant-based proteins, and unsaturated fats), and unhealthy LCDs (ULCDs: characterized by reduced intake of high-quality carbohydrates [e.g., whole grains], higher animal proteins, and saturated fats). The associations between LCD patterns and depression symptoms were evaluated using multivariable logistic regression. A restricted cubic spline (RCS) regression model was used to estimate the dose–response relationship.</div></div><div><h3>Results</h3><div>Comparing extreme quartiles of HLCDs, the adjusted odds ratio (OR) (95 % CI) for depression was 0.70 (0.57, 0.86) (<em>P</em>-trend &lt;0.001). No statistical significance was observed in ULCDs and depression symptoms. Non-linear relationships were identified for OLCDs (<em>P</em>-non-linear = 0.017), HLCDs (<em>P</em>-non-linear &lt;0.001), with depression symptoms.</div></div><div><h3>Conclusion</h3><div>Macronutrient quality modifies LCD-depression associations, with healthier patterns showing inverse correlations. Our finding indicates inverse association between HLCDs and depression risk. Further longitudinal or interventional studies are required to validate these findings and explore mechanistic pathways.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 411-417"},"PeriodicalIF":3.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the changes from ICD-10 to ICD-11 in the diagnosis of depressive disorder in the general population","authors":"Lea Francia ,&nbsp;Marta Miret ,&nbsp;Elvira Lara ,&nbsp;Blanca Dolz Del Castellar ,&nbsp;Joan Domenech-Abella ,&nbsp;Beatriz Olaya ,&nbsp;Josep Maria Haro ,&nbsp;Daniel Morillo Cuadrado ,&nbsp;José Luis Ayuso Mateos","doi":"10.1016/j.jpsychires.2025.03.012","DOIUrl":"10.1016/j.jpsychires.2025.03.012","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization recently revised the criteria for the diagnosis of depressive disorders in the International Classification of Diseases (ICD). This most recent version of the classification (ICD-11) presents some notable differences from the previous one that may impact the prevalence rate.</div></div><div><h3>Objective</h3><div>This study aims to assess the impact of changes on the diagnosis of depressive episodes in the general population.</div></div><div><h3>Method</h3><div>We used a general population sample (<em>n</em> = 2911; Age, <em>M</em> = 59; Gender, 56 % women) from the project ‘Edad con Salud’ using face-to-face interviews based on the Composite International Diagnostic Interview Instrument. To explore the impact of changes between ICD-10 and ICD-11, we compared participants with a diagnosis of a depressive disorder and those without, as well as participants who presented depression in only one of the two versions.</div></div><div><h3>Results</h3><div>When using the ICD-10 criteria, we identified 189 cases of depressive episodes against 186 with ICD-11. Five and two participants were respectively diagnosed only with ICD-10 and ICD-11. The weighted lifetime prevalence is identical using both diagnostic criteria (6.3 %).</div></div><div><h3>Conclusion</h3><div>Despite the changes introduced in the classification, the prevalence of depressive episodes identified by ICD-10 and ICD-11 in a general population sample is almost identical.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 367-370"},"PeriodicalIF":3.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-definition transcranial direct current stimulation on drug craving in patients with methamphetamine use disorder","authors":"Simin Hou ,&nbsp;Jie Wang ,&nbsp;Yufang Gao ,&nbsp;Yidan Zhang ,&nbsp;Haoyu Wang ,&nbsp;Zuoliang Li ,&nbsp;Lushi Jing","doi":"10.1016/j.jpsychires.2025.03.010","DOIUrl":"10.1016/j.jpsychires.2025.03.010","url":null,"abstract":"<div><h3>Background</h3><div>High-definition transcranial direct current stimulation (HD-tDCS) has been used as a non-invasive brain stimulation technique in drug-addicted populations. The current study found that HD-tDCS may reduce drug craving in methamphetamine (MA) addicts by stimulating the left and right sides of the dorsolateral prefrontal cortex (DLPFC) in the brain.</div></div><div><h3>Methods</h3><div>In this study, 60 patients with MA use disorder were recruited and randomly assigned to three groups: the left DLPFC group, the right DLPFC group, and the sham stimulation group, the groups received a 20-min HD-tDCS intervention for 8 consecutive days. The stimulation intensity was set at 1.5 mA, but in the sham stimulation group, the current increased to 1.5 mA within 30 s of the start of the intervention, and then rapidly decreased to 0 to cause the stimulation sensation. All groups completed tests related to physiological, explicit and implicit drug craving during the pre and post-testing phases, and were followed up after 1 month.</div></div><div><h3>Results</h3><div>(a) compared with the pre-test data, the left and right DLPFC groups at the post-test stage showed significant decreases in heart rate values, explicit and implicit drug craving scores, while the sham stimulation group showed no significant differences; (b) the intervention effects on drug craving scores were compared between the left and right DLPFC groups found no significant differences; (c) one-month follow-up test found that compared with the pre-test, the left and right DLPFC groups follow-up test explicit craving scores were significantly lower compared to the pre-test, but significantly higher compared to the post-test; also implicit drug craving scores were not significantly different compared to the pre-test, but increased compared to the post-test.</div></div><div><h3>Conclusion</h3><div>These results suggest that eight consecutive sessions of HD-tDCS may be effective in reducing immediate drug craving in patients with MA use disorder, but whether the effects of the intervention are sustained needs to be confirmed by further research.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 386-394"},"PeriodicalIF":3.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}