Journal of psychiatric research最新文献

{"title":"Drug blood levels, influencing factors and their relationship with metabolic parameters in patients with schizophrenia using clozapine","authors":"Gökcen Kumandas Sigan ,&nbsp;Saliha Ozsoy ,&nbsp;Cigdem Karakukcu ,&nbsp;Hatice Saracoglu ,&nbsp;Salim Cagatay Kagizman","doi":"10.1016/j.jpsychires.2025.09.038","DOIUrl":"10.1016/j.jpsychires.2025.09.038","url":null,"abstract":"<div><div>Clozapine stands out as the superior antipsychotic for treatment-resistant schizophrenia. Therapeutic drug monitoring (TDM) for clozapine can potentially reduce side effects, enhance treatment compliance, and ensure optimal therapeutic response. This study aimed to measure clozapine blood levels, to determine the factors affecting blood levels, and to investigate the relationship with metabolic values. This study included 80 patients with schizophrenia. Clinical assessments were conducted using the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression Scale (CGI), and the UKU Side Effect Rating Scale. Measurements included waist circumference, body weight, height, blood pressure, routine complete blood count, and biochemical data. Serum clozapine and its metabolite norclozapine levels were measured by liquid chromatography-mass spectrometry (LC/MS-MS). Elevated clozapine blood levels, exceeding the recommended therapeutic range, were observed in 71.25 % of patients despite normal dosing. Body weight, body mass index (BMI), waist circumference, triglyceride, and total cholesterol levels were high in patients with high clozapine blood levels. Female patients had higher norclozapine levels than males. Although clozapine blood levels did not significantly differ between smokers and non-smokers, the concentration-to-dose ratio was higher in smokers. Metabolic side effects can be reduced by keeping clozapine blood levels within the therapeutic range by adjusting the individualized dosing by considering the characteristics, such as gender and smoking status of patients with schizophrenia using clozapine. Appropriate therapeutic blood levels may be achieved by using lower doses of clozapine in the Turkish population.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 363-371"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in non-fatal suicidal behaviors linked to concurrent use of cannabis and opioids","authors":"Nawar Nayeem ,&nbsp;Samantha Sijing Wang ,&nbsp;Aniketh Naidu ,&nbsp;Erick Messias ,&nbsp;Ping-I Lin","doi":"10.1016/j.jpsychires.2025.09.046","DOIUrl":"10.1016/j.jpsychires.2025.09.046","url":null,"abstract":"<div><h3>Background</h3><div>Cannabis and opioids are among the most misused substances in the U.S. Growing evidence suggests gender differences in how substance use impacts mental health, particularly non-fatal suicidal behaviors. This study investigates whether the joint effect of cannabis and opioid use on non-fatal suicidal behaviors differs between men and women</div></div><div><h3>Methods</h3><div>We extracted data on US citizens from the All of Us (AoU) Research Program (N = 152,930; ages 18–49) and used logistic regression models to assess whether cannabis and opioid uses and their interaction were associated with non-fatal suicidal behaviors (suicidal ideation, attempts, or self-harm), controlling for demographic and psychiatric variables</div></div><div><h3>Results</h3><div>In the study population, 3.2 % of participants used cannabis, 2.3 % used opioids, and 2.5 % experienced non-fatal suicidal behaviors. We found that the co-use of cannabis and opioids was associated with a smaller-than-expected increase in non-fatal suicidal behaviors overall and among women, suggesting an attenuated rather than additive risk (β = −0.58 overall; β = −0.87 in women; both p &lt; 0.001). In men, however, this joint effect did not significantly differ from additivity (β = −0.29, p = 0.07), indicating a potential greater vulnerability</div></div><div><h3>Conclusions</h3><div>These findings underscore gender-specific differences in the relationship between polysubstance use and suicidality, with implications for tailoring suicide risk screening and intervention programs. Understanding how cannabis and opioid co-use influences non-fatal suicidal behaviors differently across genders is crucial for developing targeted prevention efforts. Future research should explore the biological, psychological, and social mechanisms driving these disparities to inform more effective harm reduction strategies and mental health interventions</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 170-176"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between psychiatric hospitalization and suicidal behavior among people presenting to the emergency department with mental disorders","authors":"Jessica S. Enns ,&nbsp;Natalie P. Mota ,&nbsp;James M. Bolton ,&nbsp;Okechukwu Ekuma ,&nbsp;Dan Chateau ,&nbsp;Harpreet Chahal ,&nbsp;Jitender Sareen ,&nbsp;Laurence Y. Katz","doi":"10.1016/j.jpsychires.2025.09.051","DOIUrl":"10.1016/j.jpsychires.2025.09.051","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the risk of suicidal behaviors at follow-up among patients with mental disorders seeking help in the emergency department and hospitalized versus those not hospitalized.</div></div><div><h3>Methods</h3><div>Administrative data was used to identify 9606 adults, who presented to the Emergency Department (ED) in Manitoba, Canada between 2009 and 2016 with a mental disorder and a subgroup of 1794 individuals who presented specifically with a suicide attempt. They were followed until 2018 on outcomes of suicide deaths and suicide attempts, comparing those who were hospitalized versus discharged from the ED. Inverse probability of treatment weights (IPTW) were applied in Cox proportional hazards models to adjust for confounding variables including: sex, region, age, income quintile, justice involvement, income assistance, foster care involvement, dispensed psychotropic medications, high school completion, physical comorbidities and suicide attempts.</div></div><div><h3>Results</h3><div>After adjustment, future hospitalizations for suicide attempts were more likely among individuals who were hospitalized compared to those who were discharged, among both those who presented to the ED with a mental disorder (Hazard Ratio (HR) 3.09, Confidence Interval (CI) [2.70–3.54]) and those who presented specifically with a suicide attempt (HR 2.66, CI [2.20–3.20]). However, there was no statistically significant difference in suicide death rate among those who were hospitalized compared to those who were discharged after presenting with a mental disorder, or suicide attempt specifically.</div></div><div><h3>Conclusions</h3><div>This study observed a higher risk of suicide attempts with re-hospitalization at follow-up among patients with mental disorders who were initially hospitalized after an emergency department presentation compared to those discharged. These study findings suggest that hospitalization was not associated with risk of suicide. Further research is critical to develop interventions to reduce suicide risk among individuals seeking help in the ED.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 547-553"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered frontoparietal EEG rhythms in mild cognitive impairment during high-recall movie-watching","authors":"Hua Ren ,&nbsp;Ziqi Wang ,&nbsp;Ao Xie ,&nbsp;Yulin He ,&nbsp;Zihao Zheng ,&nbsp;Hongyi Li ,&nbsp;Yang Liu ,&nbsp;Dezhong Yao ,&nbsp;Tiejun Liu ,&nbsp;Li Dong","doi":"10.1016/j.jpsychires.2025.09.059","DOIUrl":"10.1016/j.jpsychires.2025.09.059","url":null,"abstract":"<div><div>Engaging with movies as a high-cognitive task is an effective method for stimulating brain activity. However, the impact of mild cognitive impairment (MCI) on brain activity in higher-order regions related to autobiographical memory recall during movie watching remains unclear. In this study, we recorded the EEG of 43 healthy control (HC) individuals and 35 patients with MCI while they watched short old movie clips: one with low recall for 5 min and another with high recall for 5 min. The relationships between power indices and neuropsychological test results were assessed using Pearson's correlations coefficients. The main results showed significant differences in EEG spectrum change between MCI and HC groups during high and low recall movie-watching. These differences were observed in the frontal regions in the delta (1–4 Hz) band and in the parietal region in beta1 (12.5–18.5 Hz) and beta2 (18.5–21 Hz) bands (<em>p &lt;</em> 0.05, false discovery rate adjusted). Furthermore, the different variations in EEG spectrum changes between conditions of watching movies with high versus low recall significantly associated with neuropsychological test, such as the Montreal Cognitive Assessment (MoCA) (<em>r</em> = 0.3580, <em>p</em> = 0.0005) and the Minimum Mental State Examination (MMSE) (<em>r</em> = 0.2607, <em>p</em> = 0.0212). These findings indicate that patients with MCI may experience impaired brain function activation during high recall movie watching. This study also underscores the potential of movie-watching-specific EEG biomarkers for assessing MCI.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 323-332"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between muscle strength and dementia in middle-aged and older adults: A nationwide longitudinal study","authors":"Wei Jin ,&nbsp;Sheng Liu ,&nbsp;Li Huang ,&nbsp;Xi Xiong ,&nbsp;Huajian Chen ,&nbsp;Zhenzhen Liang","doi":"10.1016/j.jpsychires.2025.09.043","DOIUrl":"10.1016/j.jpsychires.2025.09.043","url":null,"abstract":"<div><h3>Background</h3><div>As the population aging of the world, the number of people with dementia is increasing. The aim of this study was to investigate the potential impact of muscle strength on the risk of dementia among middle-aged and older adults in the UK.</div></div><div><h3>Methods</h3><div>This study used data from 5916 participants aged 50 years and over from the English Longitudinal Study of Ageing (ELSA) with a median follow-up of 9.2 years. Muscle strength was assessed by handgrip strength (HGS), standardized HGS (BMI- or weight-standardized), and chair-rising time, with participants categorized into tertiles by gender based on these measures. Cox Proportional Hazards Model was used to assess the association between muscle strength and risk of dementia.</div></div><div><h3>Results</h3><div>A total of 197 participants (3.33 %) developed dementia during follow-up. Regarding HGS, participants with low HGS had a higher risk of dementia (HR = 2.84, 95 % CI: 1.64–4.91). In analyses of standardized grip strength, participants with low muscle strength were also associated with a higher risk of dementia: BMI-standardized grip strength (HR = 2.20, 95 % CI: 1.35–3.58) and weight-standardized grip strength (HR = 1.74, 95 % CI: 1.11–2.74). In addition, those who spent more time standing had a higher risk of dementia than those who spent less (HR = 2.75, 95 % CI: 1.71–441) in an analysis of Chair rising time, which represents lower limb muscle strength. Subgroup analyses showed that these associations remained stable across age [in the middle-aged (50–64 years) and elderly (≥65 years) groups] and sex groups. The results of sensitivity analyses after excluding participants diagnosed with dementia within 2 years of baseline remained consistent with the main analysis.</div></div><div><h3>Conclusions</h3><div>In conclusion, this study demonstrated that muscle strength (including HGS, standardized HGS and Chair rising time) is strongly associated with the development of dementia. Thus, muscle strength (including upper and lower extremity strength) plays a key role in preventing and delaying dementia, highlighting the importance of extremity muscle strength in dementia risk assessment. These findings provide new perspectives for the development of muscle strength intervention strategies in middle-aged and older populations and provide a scientific basis for the early detection and prevention of dementia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 189-197"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG microstates as biomarkers of drug-naïve major depressive disorder in young adults with non-suicidal self-injury","authors":"Ciqing Bao ,&nbsp;Qiaoyang Zhang ,&nbsp;Haowen Zou ,&nbsp;Wubin Chen ,&nbsp;Yi Xia ,&nbsp;Rui Yan ,&nbsp;Zhijian Yao ,&nbsp;Qing Lu","doi":"10.1016/j.jpsychires.2025.09.041","DOIUrl":"10.1016/j.jpsychires.2025.09.041","url":null,"abstract":"<div><h3>Background</h3><div>Resting-state networks within the brain manifest a dynamic interplay of stable and transient topological configurations, recognized as microstates. Non-suicidal self-injury (NSSI) is considered to involve abnormal neural activity and connectivity. However, the specific patterns of EEG microstates in major depressive disorder patients (MDD) with NSSI remain unclear.</div></div><div><h3>Methods</h3><div>We obtained resting-state electroencephalogram (EEG) from 102 drug-naïve MDD patients—46 with NSSI behavior, and 56 without—alongside 50 healthy controls. Employing the EEG microstate analysis method, we computed the principal indicators for four distinct classic microstates (A-D), encompassing duration, occurrence, time coverage, and transitional probability.</div></div><div><h3>Results</h3><div>Compared to the HC group and nNSSI group, the NSSI group showed significantly increased coverage for microstate C. The HC and NSSI groups demonstrated similar performances in microstates A and B. Additionally, HCs had higher coverage and duration of microstate D than both MDD patients (NSSI and nNSSI). We also observed heightened transition probabilities from microstates A and D to C in the NSSI group. In all MDD patients, the frequency of NSSI across time frames (past 1 month, 6 months, 1 year) exhibits a positive correlation with the coverage of microstate C.</div></div><div><h3>Conclusion</h3><div>Young adults with drug-naïve MDD and NSSI behavior exhibit unique microstate dynamics. These results imply that EEG microstates C could potentially be utilized as neurobiological markers to identify NSSI in individuals with MDD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 238-246"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-inflammatory biomarkers associated with depression severity among adults with HIV in New York City","authors":"Patrick Veihman ,&nbsp;Shivani Kaw ,&nbsp;D. Scott Batey ,&nbsp;Rebecca Schnall ,&nbsp;Joseph Belloir","doi":"10.1016/j.jpsychires.2025.09.033","DOIUrl":"10.1016/j.jpsychires.2025.09.033","url":null,"abstract":"<div><h3>Context</h3><div>Combination antiretroviral therapy (cART) has greatly improved the lifespan of people living with HIV (PWH). As the PWH population ages, the prevalence of comorbidities increases. Depression is among one of the most prevalent comorbidities of HIV and associated with higher immune and inflammatory responses. The effects of depression among PWH can lead to cART non-adherence, leading to worse health outcomes and poorer quality of life. This paper is a direct response to the CHAMPS randomized control trial (NCT05938413) of 300 PWH in both Alabama and New York City (NYC) with suboptimal primary care appointment adherence. Participants were randomly assigned to the intervention arm (receive CleverCap pill bottle to track medication adherence, communication with community health workers) or control arm (standard of care).</div></div><div><h3>Objectives</h3><div>To examine the association of pro-inflammatory biomarkers associated with depression among PWH.</div></div><div><h3>Methods</h3><div>138 PWH (age range 23–70) enrolled in the CHAMPS study in NYC completed baseline, 6-month, and 12-month follow-up visits where they completed surveys and gave blood samples. CD4 and HIV-1 viral loads were obtained through blood draw at each timepoint. Biomarker data was only collected at the baseline visit. Statistical and linear regression analyses were performed to determine associations.</div></div><div><h3>Results</h3><div>Among CD14, IFN-γ, and TNF-α, higher depression severity scores were associated with CD14 (p = 0.029) and IFN-γ (p = 0.003) via linear regression. Identifying as Latinx was also associated with higher PHQ-8 scores.</div></div><div><h3>Conclusions</h3><div>These findings contribute to a growing body of evidence linking depression with immune activation and inflammatory pathways in PWH. Future studies should examine these associations alongside social and clinical factors to guide targeted interventions and improve outcomes for PWH.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 148-154"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of the brief suicide cognitions scale with high-risk inpatient, outpatient, and emergency department clinical samples","authors":"M. David Rudd ,&nbsp;Gretchen J. Diefenbach ,&nbsp;David F. Tolin ,&nbsp;Andrea Pérez-Muñoz ,&nbsp;Taylor Flowers ,&nbsp;Burak Tuna ,&nbsp;Vivian L. Gleason ,&nbsp;Jacob Tempchin ,&nbsp;Craig J. Bryan","doi":"10.1016/j.jpsychires.2025.09.034","DOIUrl":"10.1016/j.jpsychires.2025.09.034","url":null,"abstract":"<div><div>The current study explored the clinical utility of the Brief Suicide Cognitions Scale (B-SCS) in multiple samples, including a normative sample and three clinical samples with varying degrees of suicide risk. Derived cutting scores were identical across an inpatient randomized clinical trial (RCT) sample, an emergency department (ED) sample, and an inpatient consecutive admission sample, with B-SCS scores at intake correctly predicting 96 % and 94 % of suicide attempts over six-month follow-up periods in the RCT and ED samples, respectively. Additionally, the B-SCS intake scores in the RCT sample predicted differences in high and low suicide ideation groups over the six-month follow-up period, with those below the B-SCS intake cutoff score reporting suicidal ideation scores within normal limits throughout the entirety of post-discharge follow-up. Current results support the recommendation that evaluation of the clinical utility of instruments identifying suicide risk require variable criteria depending on the specific clinical context and related clinical decision-making. With respect to post-discharge monitoring and related treatment tailoring for inpatient and ED clinical environments, instruments with strong sensitivity and high negative predictive value (NPV) estimates are of particular importance given the need to accurately recognize both the resolution of an acute episode of suicide risk and identify those vulnerable for future episodes. In the current study, the B-SCS had sensitivity estimates of .96 and .94 and NPV estimates of .97 and .93. in these clinical settings. Implications for day-to-day practice, the need for future research, and study limitations are discussed.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 155-161"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of individualized noninvasive brain stimulation targets in treating psychiatric disorders: A network meta-analysis","authors":"Yanbin Zheng ,&nbsp;Xin Luo ,&nbsp;Bo Yang ,&nbsp;Shengjia Liu ,&nbsp;Qinxuan Li ,&nbsp;Weijie He ,&nbsp;Yijun Hu ,&nbsp;Zhangzhushan Zhou ,&nbsp;Shuer Ye ,&nbsp;Xianwei Che ,&nbsp;Guang-Heng Dong","doi":"10.1016/j.jpsychires.2025.09.029","DOIUrl":"10.1016/j.jpsychires.2025.09.029","url":null,"abstract":"<div><h3>Background</h3><div>Noninvasive brain stimulation (NIBS) techniques have gained increasing attention in psychiatric research and treatment. Target selection for NIBS is becoming increasingly individualized based on brain morphology or function; however, the extent to which individualized targeting improves treatment outcomes in psychiatric disorders remains a matter of debate.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Scopus, Web of Science, PsycINFO, ProQuest and Embase published up to April 30, 2024, comparing individualized NIBS targets, standardized group-based targets, and sham stimulation in psychiatric populations. A network meta-analysis was conducted to compare the effectiveness of these approaches across different psychiatric disorders.</div></div><div><h3>Results</h3><div>A total of 35 studies comprising 1,651 patients were included. Surface under the cumulative ranking (SUCRA) plot showed that individualized targeting ranked highest among the three approaches; however, the difference between individualized and group-based methods was not statistically significant (Mean Difference (MD) = -0.045; 95% CI: −0.244 to 0.333; <em>p</em> = 0.310). Subgroup analysis further categorized individualized methods into PET-, MRI-, fMRI-, and EEG-guided approaches. PET-guided targeting demonstrated significant superiority compared to both sham and group-based targets (MD = -0.744; 95% CI: −1.450 to −0.037; <em>p</em> = 0.039). Disorder-specific analyses revealed varied results in the forest map (schizophrenia: <em>p</em> &lt; 0.01; OCD: <em>p</em> = 0.11; MDD: <em>p</em> = 0.22; addiction: <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>There is a growing trend suggesting that individualized NIBS approaches may be more effective than standardized protocols. However, further validation, especially through high-quality, large-sample randomized control trials focused on PET-guided targeting is needed. From a clinical perspective, structural MRI provides a practical option for anatomical targeting, while EEG and fMRI offer promising, cost-effective alternatives for capturing functional dynamics. Future research should prioritize long-term follow-up studies and explore clinically feasible individualized strategies to advance precision neuromodulation in psychiatric care.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 247-261"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Exploring emotion regulation in PTSD with Insomnia: A task-based fMRI study”[J. Psychiatr. Res. 189 (2025) 125–137]","authors":"Yuyi Zhang ,&nbsp;Yunxiao Guo ,&nbsp;Xiaoqin Wang ,&nbsp;Yinong Liu ,&nbsp;Sijun Liu ,&nbsp;Junrong Zhao ,&nbsp;Lianzhong Liu ,&nbsp;Ping Yu ,&nbsp;Zhihong Ren","doi":"10.1016/j.jpsychires.2025.09.021","DOIUrl":"10.1016/j.jpsychires.2025.09.021","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 115-118"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}