Pro-inflammatory biomarkers associated with depression severity among adults with HIV in New York City

IF 3.2 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-09-24 DOI:10.1016/j.jpsychires.2025.09.033

Patrick Veihman , Shivani Kaw , D. Scott Batey , Rebecca Schnall , Joseph Belloir

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引用次数: 0

Abstract

Context

Combination antiretroviral therapy (cART) has greatly improved the lifespan of people living with HIV (PWH). As the PWH population ages, the prevalence of comorbidities increases. Depression is among one of the most prevalent comorbidities of HIV and associated with higher immune and inflammatory responses. The effects of depression among PWH can lead to cART non-adherence, leading to worse health outcomes and poorer quality of life. This paper is a direct response to the CHAMPS randomized control trial (NCT05938413) of 300 PWH in both Alabama and New York City (NYC) with suboptimal primary care appointment adherence. Participants were randomly assigned to the intervention arm (receive CleverCap pill bottle to track medication adherence, communication with community health workers) or control arm (standard of care).

Objectives

To examine the association of pro-inflammatory biomarkers associated with depression among PWH.

Methods

138 PWH (age range 23–70) enrolled in the CHAMPS study in NYC completed baseline, 6-month, and 12-month follow-up visits where they completed surveys and gave blood samples. CD4 and HIV-1 viral loads were obtained through blood draw at each timepoint. Biomarker data was only collected at the baseline visit. Statistical and linear regression analyses were performed to determine associations.

Results

Among CD14, IFN-γ, and TNF-α, higher depression severity scores were associated with CD14 (p = 0.029) and IFN-γ (p = 0.003) via linear regression. Identifying as Latinx was also associated with higher PHQ-8 scores.

Conclusions

These findings contribute to a growing body of evidence linking depression with immune activation and inflammatory pathways in PWH. Future studies should examine these associations alongside social and clinical factors to guide targeted interventions and improve outcomes for PWH.

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纽约市成年HIV感染者中与抑郁严重程度相关的促炎生物标志物

联合抗逆转录病毒治疗（cART）大大提高了艾滋病毒感染者（PWH）的寿命。随着PWH人口的老龄化，合并症的患病率增加。抑郁症是艾滋病毒最常见的合并症之一，与较高的免疫和炎症反应有关。抑郁症对PWH的影响可能导致cART不依从性，导致更差的健康结果和更差的生活质量。这篇论文是对CHAMPS随机对照试验（NCT05938413）的直接回应，在阿拉巴马州和纽约市（NYC）的300名PWH中，初级保健预约依从性不理想。参与者被随机分配到干预组（接收CleverCap药瓶以跟踪药物依从性，与社区卫生工作者沟通）或控制组（标准护理）。目的探讨PWH患者与抑郁相关的促炎生物标志物的相关性。方法138名PWH（年龄23-70岁）参加了纽约市CHAMPS研究，完成了基线、6个月和12个月的随访，在随访中他们完成了调查并提供了血液样本。在每个时间点通过抽血获得CD4和HIV-1病毒载量。生物标志物数据仅在基线访问时收集。进行统计和线性回归分析以确定相关性。结果在CD14、IFN-γ和TNF-α中，高抑郁严重程度评分与CD14 （p = 0.029）和IFN-γ (p = 0.003)相关。认为自己是拉丁裔也与更高的PHQ-8分数有关。结论：这些发现有助于越来越多的证据将抑郁症与PWH的免疫激活和炎症途径联系起来。未来的研究应该检查这些关联以及社会和临床因素，以指导有针对性的干预措施和改善PWH的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;