Journal of psychiatric research最新文献

{"title":"A systematic review and meta-analysis of anxiety and depression in children and adolescents with inflammatory bowel disease: Prevalence and association","authors":"Tingting Xu ,&nbsp;Yanhong Chen ,&nbsp;Qiqi Shen ,&nbsp;Sichao Dai ,&nbsp;Haohao Yan ,&nbsp;Jianjuan Ren","doi":"10.1016/j.jpsychires.2026.02.008","DOIUrl":"10.1016/j.jpsychires.2026.02.008","url":null,"abstract":"<div><h3>Background</h3><div>Anxiety and depression are prevalent comorbidities in patients with inflammatory bowel disease (IBD). However, their prevalence and impact in children and adolescents with IBD remain poorly defined. This meta-analysis aimed (i) to estimate the prevalence of anxiety and depression in this population and (ii) to explore the association between these psychological issues and IBD.</div></div><div><h3>Methods</h3><div>A thorough search of Embase, Web of Science, and PubMed from inception through February 1, 2025, was conducted. Two authors independently extracted data and assessed study quality. Pooled prevalence estimates, odds ratios (ORs), and hazard ratios (HRs) were calculated using a random-effects model. Subgroup and sensitivity analyses were performed to examine sources of heterogeneity and assess result robustness.</div></div><div><h3>Results</h3><div>The meta-analysis included 48 studies with 189,032 children and adolescents with IBD. Pooled prevalence estimates were as follows: anxiety symptoms (12%; 95% confidence interval [CI]: 7%–17%; k [number of studies] = 14; n [number of subjects] = 1574); anxiety disorders (9%; 95% CI: 5%–14%; k = 6; n = 168,378); depressive symptoms (15%; 95% CI: 11%–19%; k = 35; n = 4426); and depressive disorder (8%; 95% CI: 5%–11%; k = 7; n = 168,475). Pooled HRs indicated a significantly higher risk of developing anxiety and depressive disorders in this population, with HRs of 1.95 and 1.65, respectively.</div></div><div><h3>Conclusions</h3><div>Children and adolescents with IBD face a substantial burden of anxiety and depression. Routine mental health screening is essential for early intervention and comprehensive management of these comorbidities.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 78-89"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of problematic smartphone use, depression, and anxiety, and their relationships with mindfulness among medical students","authors":"Zhihan Chen ,&nbsp;Junni Bai ,&nbsp;Yunan Hu ,&nbsp;Bo Zhou ,&nbsp;Yang Wang","doi":"10.1016/j.jpsychires.2026.02.014","DOIUrl":"10.1016/j.jpsychires.2026.02.014","url":null,"abstract":"<div><div>Previous studies have uncovered a negative correlation between problematic smartphone use (PSU) and both depression and anxiety, yet the investigation of PSU with depression and anxiety on a symptomatic level among medical students remains limited. This study aims to analyze the network structure of PSU and its relation to symptoms of depression and anxiety, as well as examine the role of mindfulness among these factors. A sample of 456 medical students was assessed using the Smartphone Addiction Scale - Short Version (SAS-SV), the nine-item Patient Health Questionnaire (PHQ-9), the seven-item Generalized Anxiety Disorder Scale (GAD-7), and the Mindful Attention Awareness Scale (MAAS). Network analysis was employed to build the network structure and to identify central and bridge symptoms with centrality indices. The analysis revealed that preoccupation with smartphone and withdrawal symptoms serve as central symptoms in the development of PSU among medical students. Excessive use and fatigue emerged as bridge symptoms linking PSU to depression, while excessive use and restlessness were identified as bridge symptoms connecting PSU with anxiety. Mindfulness exhibited a negative association with numerous symptoms across PSU, depression, and anxiety. The findings indicate that targeting preoccupation with smartphone and withdrawal symptoms might prevent the development of PSU among medical students. Targeting excessive use may be essential in preventing the progression of PSU to depression and anxiety. Given the backgrounds of medical students, online mindfulness interventions could be a viable approach to mitigate PSU and improve mental health among them.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 97-105"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of the bidirectional relationship between psychosis and loneliness","authors":"Ana Ortiz-Tallo ,&nbsp;Ana Izquierdo ,&nbsp;Ana Calvo ,&nbsp;Elvira Lara ,&nbsp;José Luis Ayuso-Mateos ,&nbsp;María Cabello","doi":"10.1016/j.jpsychires.2026.02.018","DOIUrl":"10.1016/j.jpsychires.2026.02.018","url":null,"abstract":"<div><h3>Background</h3><div>and hypothesis: Loneliness, defined as a subjective feeling of isolation, has been significantly correlated with psychotic experiences in general and clinical populations, although less is known about the direction of this relationship. This paper aims to systematically review the longitudinal relationship between loneliness and psychosis spectrum continuum, addressing two fundamental questions: (1) is loneliness a risk factor for the development of psychosis, and (2) does psychosis increase the risk of experiencing loneliness?</div></div><div><h3>Study design</h3><div>A comprehensive search of 5 electronic databases yielded a total of 4386 records, from which 10 observational studies were finally included.</div></div><div><h3>Study results</h3><div>Six studies investigated the first research question, and all of them identified a significant association between loneliness and the subsequent incidence of psychosis (question 1). Conversely, 4 studies explored the second research question, with 3 suggesting that individuals within the psychosis spectrum may face heightened susceptibility to loneliness (question 2). The remaining study, conducted during the COVID-19 pandemic, did not yield significant findings. Assessment of methodological quality indicated predominantly moderate-to-high-quality studies.</div></div><div><h3>Conclusions</h3><div>The findings underscore the need for further research, particularly longitudinal prospective studies, to clarify whether the observed association between loneliness and psychosis is direct or whether it is instead moderated or mediated by other variables. Overall, the available evidence provides stronger support for loneliness as a potential risk factor for the onset of psychosis, although the number of longitudinal studies addressing this question remains very limited. Addressing these gaps in knowledge could inform the development of targeted prevention programs and interventions for people with psychotic spectrum disorders.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 115-122"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating levels of glial cell line-derived neurotrophic factor in bipolar disorder: A meta-analysis of case-control studies and efficacy of therapeutic interventions","authors":"Omran Davarinejad ,&nbsp;Saeid Komasi ,&nbsp;Mohammad-Taher Moradi ,&nbsp;Fatemeh Kazemisafa","doi":"10.1016/j.jpsychires.2026.02.005","DOIUrl":"10.1016/j.jpsychires.2026.02.005","url":null,"abstract":"<div><h3>Background</h3><div>Bipolar disorder (BD) is a chronic and debilitating mental illness characterized by alternating episodes of mania and depression, affecting approximately 5-6% of the global population. Despite extensive research, the underlying pathophysiology of BD remains poorly understood, necessitating further exploration of potential biomarkers. This meta-analysis investigates peripheral levels of glial cell line-derived neurotrophic factor (GDNF) to evaluate its utility as a biomarker in individuals with BD.</div></div><div><h3>Methods</h3><div>We systematically searched four international databases, identifying 13 case-control studies (825 patients with BD vs. 885 healthy controls) and 4 clinical trials encompassing 153 patients with BD. The study adhered to PRISMA guidelines and employed rigorous quality assessment tools, including the Newcastle-Ottawa Scale for observational studies and the Cochrane Risk of Bias tool for clinical trials.</div></div><div><h3>Results</h3><div>The analysis revealed a pooled standardized mean difference of d = −0.81 [CI: 1.41 to −0.22], p = 0.007. However, extreme heterogeneity (I² &gt; 96%) and publication bias preclude reliable interpretation of this estimate. Furthermore, the meta-regression analyses were significant for illness duration, YMRS score, and year of study. Subgroup analysis showed significant estimates for blood sample, mania episode, and Asian region. Although treatment interventions increased GDNF levels, these changes were not statistically significant (<em>d</em> = 0.12, [95% CI: 0.20 to 0.44], <em>p</em> = 0.463). High heterogeneity was observed across studies, indicating substantial variability in study designs and participant characteristics.</div></div><div><h3>Conclusion</h3><div>The literature provides preliminary, highly heterogeneous evidence suggestive of altered GDNF levels in BD, primarily within serum during mania. The plasma-serum discrepancy highlights a major methodological confounder (platelet GDNF release), and the significant heterogeneity and publication bias preclude a reliable estimate of the true effect size. GDNF cannot be considered a disorder-specific biomarker for BD, as similar alterations are reported in major depression and schizophrenia. Future research must prioritize plasma measurements, standardized protocols, and longitudinal designs in medication-naïve cohorts to clarify whether GDNF acts as a state-dependent marker of acute mood episodes within a transdiagnostic framework.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 30-39"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness-based group therapy for auditory hallucination management in schizophrenia: A randomized controlled trial","authors":"Shuixian Yang ,&nbsp;Wenqing Zhou ,&nbsp;Yingying Qin ,&nbsp;Tao Zheng ,&nbsp;Fengxia Huang ,&nbsp;Chunqun Li ,&nbsp;Jingxin Dai ,&nbsp;Lina Zhou ,&nbsp;Linmin Li ,&nbsp;Fengchun Wu ,&nbsp;Qiubi Tang","doi":"10.1016/j.jpsychires.2026.02.019","DOIUrl":"10.1016/j.jpsychires.2026.02.019","url":null,"abstract":"<div><div>Auditory hallucinations, a core symptom of schizophrenia, affect 50-70% of patients and significantly impair their quality of life. Although multimodal treatments, including pharmacotherapy, psychotherapy, and neuromodulation, are commonly employed, their efficacy remains limited. This randomized controlled trial aimed to assess the effects of Mindfulness-Based Auditory Hallucination Management (MBAHM) on auditory hallucinations, anxiety, depression, and quality of life in patients with schizophrenia. Eighty patients with schizophrenia were randomly assigned to the MBAHM group (n = 40) or the control group (n = 40). The MBAHM group received a 2-h MBAHM intervention twice a week for eight weeks, while the control group received routine treatment and care. Auditory hallucinations, anxiety, depression, and quality of life were assessed at baseline and post-intervention. The results revealed that, compared to both the baseline and the control group, the MBAHM group showed significant reductions in auditory hallucinations, anxiety, and depression, along with improvements in quality of life (p &lt; 0.001). Correlation analyses further indicated significant associations between reductions in auditory hallucination severity, anxiety, and depression, alongside improvements in quality of life. These findings provide preliminary evidence that MBAHM may be an effective complementary approach for managing auditory hallucinations and improving overall well-being in patients with schizophrenia.</div></div><div><h3>Trial registration</h3><div>Chinese Clinical Trial Registry ChiCTR2400088029. Date of registration: August 09, 2024.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 53-60"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planning and problem solving across multiple psychiatric disorders in young adults","authors":"Raj A. Shetty ,&nbsp;Jon E. Grant","doi":"10.1016/j.jpsychires.2026.01.059","DOIUrl":"10.1016/j.jpsychires.2026.01.059","url":null,"abstract":"<div><h3>Introduction</h3><div>Planning and problem solving, subdomains of executive functioning, are important for daily functioning and clinical outcomes. Although executive functioning encompasses several domains, whether planning-specific deficits are a transdiagnostic feature across psychiatric disorders remains unclear.</div></div><div><h3>Methods</h3><div>Planning and problem solving in 658 young adults aged 18-29 was assessed in a cross-sectional study using the One Touch Stocking of Cambridge (OTS) task, with the number of problems solved correctly on first choice and mean latency to correct response as outcomes. Participants had a diverse range of psychiatric diagnoses, which were determined by structured clinical interviews. Planning and problem solving performance was compared between psychiatric groups and healthy controls using standardized z-scores and Cohen's d effect sizes.</div></div><div><h3>Results</h3><div>Participants with psychiatric diagnoses generally demonstrated impaired planning and problem solving compared to controls. Large effect deficits in problem-solving accuracy were found in obsessive-compulsive disorder (z = −1.32) and trichotillomania (z = −0.87). Moderate effect deficits were observed in agoraphobia, gambling disorder, panic disorder, antisocial personality disorder, compulsive buying disorder, substance abuse, and borderline personality disorder. Trichotillomania also showed the highest planning latency (z = 0.59). Results for diagnostic groups with small sample sizes should be interpreted with caution.</div></div><div><h3>Conclusion</h3><div>These data indicate that planning and problem solving may be impaired in several psychiatric disorders. Future work may wish to examine the contribution of comorbidities and psychoactive substances to the profiles identified.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 1-7"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-limited model of an evidence-based telemental health intervention in a graduate student mental health program","authors":"Suza C. Scalora ,&nbsp;Stephanie Lechich ,&nbsp;Alyssa DePasquale ,&nbsp;Helene Geramian ,&nbsp;Katharine Blodget ,&nbsp;Irena Ilieva ,&nbsp;Andrea Temkin-Yu ,&nbsp;Patricia Marino","doi":"10.1016/j.jpsychires.2026.01.062","DOIUrl":"10.1016/j.jpsychires.2026.01.062","url":null,"abstract":"<div><div>This study evaluated the feasibility, acceptability, and preliminary clinical outcomes of a time-limited, evidence-based telemental health (TMH) intervention delivered within a Graduate Student Mental Health program at a northeastern U.S. university between August 2022 and January 2023. Standard measures of depression and anxiety were collected at pre- and post-treatment and supplemented with electronic health record data for 28 participants who initiated and completed treatment.</div><div>The program consisted of 12 weekly, 45-minute individual psychotherapy sessions delivered via a HIPAA-compliant virtual platform. Feasibility was assessed using enrollment and retention, and acceptability was assessed using engagement indicators, including attendance rates. Thirty-eight students initiated treatment, and 28 completed the program (73.6% retention), with an average attendance of 9.79 of 12 sessions (SD = 2.91). Significant pre-to post-treatment reductions were observed in depression scores, (M = 9.61, SD = 5.24) to M = 5.46, SD = 3.78); t (27) = 5.50, p = &lt; .001), d = 1.04 and anxiety scores (M = 9.93, SD = 4.83) to M = 5.54, SD = 3.81); t (27) = 5.41, p = &lt; .001), d = 1.02.</div><div>These findings provide preliminary evidence that a time-limited TMH model may be a feasible and acceptable intervention for graduate students experiencing psychological distress; however, the small, self-selected, non-randomized sample and the absence of a control group limit conclusions about effectiveness and generalizability. In the context of substantial mental health needs and barriers to care in university settings, the results highlight the potential value of scalable TMH programs for expanding access to treatment among graduate students.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 24-29"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide-related metacognitions in psychiatric inpatients admitted after suicide attempt or an acute suicidal crisis: a longitudinal mediation analysis","authors":"Thomas Forkmann ,&nbsp;Tobias Teismann ,&nbsp;Jana Serebriakova ,&nbsp;Jannik Eimen ,&nbsp;Cora Spahn ,&nbsp;Sonja Omlor ,&nbsp;Peer Abilgaard ,&nbsp;Markus Frings ,&nbsp;Ralf Kudling ,&nbsp;Jens Kuhn ,&nbsp;Martin Schaefer ,&nbsp;Norbert Scherbaum ,&nbsp;Heide Glaesmer ,&nbsp;Lena Spangenberg","doi":"10.1016/j.jpsychires.2026.01.061","DOIUrl":"10.1016/j.jpsychires.2026.01.061","url":null,"abstract":"<div><h3>Background</h3><div>The metacognitive model of suicidality suggests that suicide-related metacognitions activate a Cognitive Attentional Syndrome (CAS)—including suicide-specific rumination, attentional fixation, and thought suppression—which may intensify and prolong suicidal ideation. While initial support has emerged from general population samples, longitudinal evidence in high-risk clinical populations remains lacking.</div></div><div><h3>Methods</h3><div>In a multicenter, prospective study, we examined model assumptions in a sample of 184 psychiatric inpatients (M = 37.5 years, 50% male), all admitted following a suicide attempt or severe suicidal crisis. Participants completed baseline assessments prior to discharge and engaged in a 3-week ecological momentary assessment (EMA) protocol measuring suicide-specific rumination, thought suppression, and suicidal intent up to four times daily. Past suicidal ideation and suicide-related metacognitions (positive and negative) were assessed using validated scales.</div></div><div><h3>Results</h3><div>Past suicidal ideation significantly predicted both positive and negative suicide-related metacognitions. These, in turn, prospectively predicted suicide-specific rumination but not thought suppression. Mediation analyses indicated that positive metacognitions mediated the relationship between past suicidal ideation and future suicide-specific rumination. Additionally, suicide-specific rumination—rather than thought suppression—mediated the relationship between suicide-related metacognitions and both intensity and frequency of suicidal intent during the EMA period.</div></div><div><h3>Limitations</h3><div>Attentional fixation was not assessed. EMA compliance averaged 48.3%, and some measures were adapted from preliminary versions.</div></div><div><h3>Conclusions</h3><div>Findings provide the first longitudinal support for the metacognitive model of suicidality in a clinical sample. Suicide-specific rumination and positive metacognitions may be important drivers of intensification and prolongation of suicidal ideation and suicidal intent formation in the high-risk post-discharge period.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 44-52"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between handgrip strength and incident depression: a meta-analysis of prospective cohort studies","authors":"Jênifer de Oliveira ,&nbsp;Ismael Mignoni ,&nbsp;Davy Vancampfort ,&nbsp;Liye Zou ,&nbsp;Brendon Stubbs ,&nbsp;Aline Josiane Waclawovsky ,&nbsp;Felipe Barreto Schuch","doi":"10.1016/j.jpsychires.2026.02.023","DOIUrl":"10.1016/j.jpsychires.2026.02.023","url":null,"abstract":"<div><div>A number of individual studies have suggested that higher handgrip strength is associated with a lower risk of depressive symptoms but the totality of the evidence remains inconclusive. This study aimed to investigate the association between handgrip strength and the incidence of depressive symptoms or depression and explore potential moderators of this association. We searched major databases (PubMed, Web of Science, PsycINFO, EMBASE, and SportDiscus) from inception to February 4, 2025, for prospective cohort studies evaluating the risk of incident depressive outcomes according to handgrip strength. Effect sizes extracted were the most adjusted model containing odds ratios (ORs) or relative risks (RRs) from individual studies. Random-effects meta-analyses were conducted for ORs and RRs separately, and potential moderators were explored through meta-regressions (% women, sample size, % smokers, age, number of adjustment variables, follow-up time, and person-years). Methodological quality was assessed using the Newcastle–Ottawa Scale. Twelve unique cohorts were included (N = 497,336, person-years = 3,442,910). Individuals with lower handgrip strength had higher odds of incident depressive outcomes (OR = 1.42, 95% CI = 1.14–1.78, p &lt; 0.001). Follow-up time (β = 0.0089, 95% CI = 0.0082–0.0096, R² = 1.00) and person-years (β = 0.00000057, 95% CI = 0.00000028–0.00000086, R² = 0.91) were identified as statistically significant moderators of this association, with studies showing slightly stronger associations, although the magnitude of these effects was small. The average methodological quality score of the studies was 8 (SD = 0.63), indicating overall high quality. This meta-analysis demonstrates a statistically significant but clinically small association between handgrip strength and the incidence of depressive outcomes. These findings suggest that handgrip strength may represent a convenient marker of overall health and functional resilience associated with depression risk.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 106-114"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of common antipsychotic medications with weight gain in youth and adults: a target trial emulation study","authors":"Joshua Petimar ,&nbsp;Sheryl L. Rifas-Shiman ,&nbsp;Jessica G. Young ,&nbsp;Han Yu ,&nbsp;Matthew F. Daley ,&nbsp;William J. Heerman ,&nbsp;David M. Janicke ,&nbsp;W. Schuyler Jones ,&nbsp;Kristina H. Lewis ,&nbsp;Pi-I.D. Lin ,&nbsp;Doug Lunsford ,&nbsp;L. Charles Bailey ,&nbsp;Sengwee Toh ,&nbsp;Jason P. Block","doi":"10.1016/j.jpsychires.2026.02.007","DOIUrl":"10.1016/j.jpsychires.2026.02.007","url":null,"abstract":"<div><h3>Background</h3><div>Few real-world studies have estimated differences in weight gain between antipsychotic medications. This study estimated effects of initiating 4 first-line antipsychotic medications on weight change in adults and children/adolescents.</div></div><div><h3>Methods</h3><div>Electronic health record data were collected from 31,270 adults (≥20 years) and 29,496 children/adolescents (&lt;20 years) newly prescribed 1 of 4 antipsychotics (aripiprazole, olanzapine, quetiapine, risperidone) from 2010 to 2019 across 15 U.S. health systems. Target trial emulation estimated the effect of initiating each medication on weight change in adults and body mass index z-score (BMIz) in children/adolescents at 6 (primary) and 12 months (secondary) versus aripiprazole (reference). Inverse probability weighted estimation of repeated outcome marginal structural models adjusted for baseline confounding and informative outcome measurement.</div></div><div><h3>Results</h3><div>In adults, initiation of aripiprazole was associated with greater 6-month weight change than initiation of olanzapine (difference = −0.60 kg [95% CI: −0.97, −0.25]), quetiapine (difference = −1.17 kg [-1.43, −0.91]), and risperidone (difference = −0.35 kg [-0.73, 0.03]); 12-month weight gain was similar between aripiprazole and olanzapine (difference = −0.11 [-0.61, 0.38]). In children/adolescents, olanzapine was associated with greater 6-month BMIz change than aripiprazole (difference = 0.15 [0.10, 0.20]); quetiapine and risperidone were associated with slightly smaller BMIz increases than aripiprazole. Six-month adherence was lower for olanzapine (5-7%) than other medications (15-21%) in adults and children/adolescents.</div></div><div><h3>Conclusions</h3><div>Among 4 first-line antipsychotic medications, aripiprazole was associated with the greatest 6-month weight gain in adults and olanzapine was associated with the greatest 6-month BMIz increase in children/adolescents, though adherence was lower for olanzapine than other medications. Clinicians should consider these differences in weight gain when initiating antipsychotic medications.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 90-96"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}