Journal of psychiatric research最新文献

{"title":"Corrigendum to “Trends and determinants of time spent in the emergency department among Australian hospital presenting self-harm cases” [J. Psychiatr. Res. 181 (2025) 365–372]","authors":"Swikar Poudel , Sandro Sperandei , Andrew Page , Arianne Reis , Yi Guo , Sithum Munasinghe , Kathryn Worne , Rowena Saheb , Vlasios Brakoulias","doi":"10.1016/j.jpsychires.2025.03.042","DOIUrl":"10.1016/j.jpsychires.2025.03.042","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Page 56"},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing efficacy of serotonergic, opioidergic, and glutamatergic drugs in gambling disorder: A pooled analysis of response trajectories versus placebo","authors":"Mauro Pettorruso ,&nbsp;Francesco Di Carlo ,&nbsp;Giorgio Di Lorenzo ,&nbsp;Carmine Gelormini ,&nbsp;Roberto Guidotti ,&nbsp;Giovanni Martinotti ,&nbsp;Jon E. Grant","doi":"10.1016/j.jpsychires.2025.03.056","DOIUrl":"10.1016/j.jpsychires.2025.03.056","url":null,"abstract":"<div><div>Various pharmacological treatments have been explored to alleviate the symptoms and clinical manifestations of gambling disorder (GD) by targeting different neurotransmitter systems. This study retrospectively analyzed subjects with GD treated with serotonergic drugs, opioid antagonist drugs, and glutamatergic drugs compared to placebo, through a pooled analysis of clinical trials conducted at the University of Chicago. The Gambling Symptom Assessment Scale (G-SAS) was employed as the outcome measure. Temporal uniformity was ensured by managing timepoints as follows: baseline, early (4–5 weeks), intermediate (6–8 weeks), and final (10–16 weeks) from the start of treatment.</div><div>A total of 253 treatment-seeking subjects were included, receiving either glutamatergic drugs (N-acetylcysteine, memantine), opioidergic drugs (naltrexone), serotonergic drugs (paroxetine, escitalopram), or placebo. Within-group analysis demonstrated significant improvement in GD symptoms across all treatment groups. When comparing interventions over time, glutamatergic drugs proved more effective than placebo from the early observation timepoint and onwards. Opioidergic drugs were more effective than placebo at the final observation timepoint, while serotonergic drugs showed no significant effect compared to placebo.</div><div>Our findings reveal distinct efficacy patterns among the pharmacological classes, likely due to their different mechanisms of action and the various aspects of GD phenomenology they address. The significant placebo effect observed aligns with previous studies, underscoring the complexity of treating GD. In conclusion, given the heterogeneous nature of GD, these results emphasize the necessity of identifying and precisely characterizing GD subtypes to facilitate more tailored treatment approaches.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 112-118"},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of physical activity in the prospective association between body mass index and depressive symptoms in mothers from the 2015 Pelotas (Brazil) Birth Cohort","authors":"Luciana Tornquist ,&nbsp;Debora Tornquist ,&nbsp;Inácio Crochemore-Silva ,&nbsp;Gregore Iven Mielke ,&nbsp;Mariângela Freitas da Silveira ,&nbsp;Pedro Curi Hallal ,&nbsp;Marlos Rodrigues Domingues","doi":"10.1016/j.jpsychires.2025.03.051","DOIUrl":"10.1016/j.jpsychires.2025.03.051","url":null,"abstract":"<div><div>Maternal obesity has been associated with postpartum depression and a protective role of physical activity is indicated. This study aims to examine the role of moderate and vigorous physical activity (MVPA) in the prospective association between body mass index (BMI) and depressive symptoms in a cohort of mothers. Depressive symptoms were assessed at 3 and 48 months postpartum using the Edinburgh Depression Scale. BMI was calculated from weight and height measurements at 24 months postpartum and self-reported pre-pregnancy weight. MVPA was measured by accelerometers at 12–16 weeks of pregnancy and 24 months postpartum. Accelerometry data were available for 1953 mothers in pregnancy and 2546 postpartum. BMI was not significantly associated with depressive symptoms. However, the relationship between pre-gestational BMI and depressive symptoms 3 months postpartum was moderated by MVPA (p = 0.04). Among mothers with low MVPA, the association between BMI and depressive symptoms was not significant. However, among those who performed ≥42 min of MPVA/day, the relationship became significant and inverse (β: −0.125; 95 %CI: −0.248; −0.001), with mothers with higher BMI and high MVPA having lower depressive symptom scores<strong>.</strong> In conclusion, MVPA performs a positive role in the association between BMI and depressive symptoms, reinforcing the importance of MVPA promotion among mothers.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 161-168"},"PeriodicalIF":3.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous activity and functional connectivity in patients with hoarding disorder comorbid with attention-deficit/hyperactive disorder","authors":"Hirofumi Tomiyama ,&nbsp;Keitaro Murayama ,&nbsp;Kenta Kato ,&nbsp;Akira Matsuo ,&nbsp;Nami Nishida ,&nbsp;Kou Matsukuma ,&nbsp;Makoto Kawahito ,&nbsp;Mingi Kang ,&nbsp;Kenta Sashikata ,&nbsp;Koji Yamashita ,&nbsp;Kazufumi Kikuchi ,&nbsp;Tatsuhiro Wada ,&nbsp;Osamu Togao ,&nbsp;Tomohiro Nakao","doi":"10.1016/j.jpsychires.2025.03.055","DOIUrl":"10.1016/j.jpsychires.2025.03.055","url":null,"abstract":"<div><div>Despite recent studies suggesting an important association of hoarder disorder (HD) and attention-deficit/hyperactive disorder (ADHD), no neuroimaging study has investigated the differences between patients with HD comorbid with ADHD and those without ADHD. This study investigated the regional spontaneous activity and functional connectivity in HD, focusing on the comorbidity with ADHD.</div><div>Resting-state functional magnetic resonance imaging (MRI) data were obtained from 24 patients with HD and 31 healthy individuals. We investigated the group differences using the fractional amplitude of low-frequency fluctuation (fALFF). The altered regions in the fALFF were used as seeds in a functional connectivity analysis where we conducted group comparisons among the three groups: healthy controls (HCs), HD with ADHD (HD +ADHD), and HD without ADHD (HD -ADHD).</div><div>Compared to HCs, patients with HD had a reduced fALFF in the right inferior frontal gyrus (IFG). Functional connectivity analysis revealed that patients with HD + ADHD had reduced functional connectivity between the IFG and dorsolateral prefrontal cortex (DLPFC) compared to HCs, while the HD -ADHD group was intermediate level between HD +ADHD and HCs groups.</div><div>In conclusion, patients with HD have altered spontaneous activity of the IFG. Additionally, patients with HD + ADHD had significantly reduced functional connectivity between the IFG and the DLPFC. Our findings suggest the potential need to distinguish between subgroups of HD+ADHD to identify novel neurobiological models of HD that could guide future therapeutic strategies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 98-104"},"PeriodicalIF":3.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of personality traits on daily functioning: A study on a group of help-seeking young adults","authors":"Chiara Rossi ,&nbsp;Lorenzo Antichi ,&nbsp;Francesca De Salve ,&nbsp;Marco Aldegheri ,&nbsp;Antonio Basilisca ,&nbsp;Sonia Facchetti ,&nbsp;Erika Riva ,&nbsp;Matteo Sala ,&nbsp;Paola Scovazzi ,&nbsp;Luca Micheletti ,&nbsp;Giorgio Bianconi ,&nbsp;Giovanna Valvassori Bolgè ,&nbsp;Osmano Oasi","doi":"10.1016/j.jpsychires.2025.03.049","DOIUrl":"10.1016/j.jpsychires.2025.03.049","url":null,"abstract":"<div><h3>Introduction</h3><div>Functional impairment is a common issue among patients with mental health disorders and first-episode psychosis who seek assistance from public mental health services designed for early intervention. These services often provide brief psychotherapeutic treatments to enhance social and professional functioning. However, the effectiveness of these brief interventions varies. Identifying risk factors for mental disorders, such as specific personality traits, could inform the development of more effective early intervention strategies. This study aims to identify significant personality traits as predictors of social and occupational functioning among help-seeking young adults at ASST Ovest Milanese public mental health services in Northern Italy.</div></div><div><h3>Methods</h3><div>Data were collected from 229 participants (82 males, 147 females) aged 18–27 (M = 24.13; SD = 2.21). Participants completed a socio-demographic questionnaire, the Personality Inventory for DSM-5, and the Social and Occupational Functioning Assessment Scale. Regression models, Random Forest, and Gradient Boosting Machines were conducted.</div></div><div><h3>Results</h3><div>The regression model with Detachment as the only predictor provided the best fit, indicating that higher levels of Detachment are significantly associated with lower social and occupational functioning (MSE = 112.38, adjusted R² = 0.1188, p &lt; 0.001). Including Negative Affectivity and Disinhibition in the model did not improve predictive power and introduced overfitting. Additionally, some socio-demographic factors were positively associated with better functioning.</div></div><div><h3>Conclusion</h3><div>Detachment is a primary predictor of social and occupational impairment. Interventions should prioritize addressing detachment-related traits and integrate educational and vocational support to enhance functioning. Implementing individualized therapies based on these risk factors could improve mental health outcomes and reduce costs for public clinical facilities.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 146-153"},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships between clinician adherence to guideline-recommended treatment and memory function in patients with schizophrenia","authors":"Yasushi Kawamata ,&nbsp;Kazutaka Ohi ,&nbsp;Satsuki Ito ,&nbsp;Naomi Hasegawa ,&nbsp;Yuka Yasuda ,&nbsp;Michiko Fujimoto ,&nbsp;Hidenaga Yamamori ,&nbsp;Kentaro Fukumoto ,&nbsp;Fumitoshi Kodaka ,&nbsp;Junya Matsumoto ,&nbsp;Norio Yasui-Furukori ,&nbsp;Ryota Hashimoto","doi":"10.1016/j.jpsychires.2025.03.054","DOIUrl":"10.1016/j.jpsychires.2025.03.054","url":null,"abstract":"<div><h3>Background</h3><div>Memory function impairment is severe in patients with schizophrenia, but improving memory function remains challenging. The use of benzodiazepines and anticholinergics, which are not recommended by pharmacological therapy guidelines for schizophrenia, has been associated with worsened cognitive function. However, it remains unclear whether better adherence by psychiatrists to pharmacological therapy guidelines for schizophrenia is associated with improved memory function. Therefore, we investigated the relationship between psychiatrists’ adherence and memory function in patients with schizophrenia.</div></div><div><h3>Methods</h3><div>To evaluate the associations between psychiatrists' adherence to pharmacological therapy guidelines and memory function, we utilized the Individual Fitness Score (IFS), which includes multiple quality indicators, to assess each psychiatrist's adherence to these guidelines in treating each patient. Memory function was measured using the Wechsler Memory Scale-Revised in a total of 351 patients, including 40 patients with treatment-resistant schizophrenia (TRS) and 311 patients with non-TRS.</div></div><div><h3>Results</h3><div>We found that psychiatrist adherence was significantly positively correlated with verbal memory (<em>β</em> = 0.145, <em>p</em> = 6.45 × 10⁻³), attention/concentration (<em>β</em> = 0.138, <em>p</em> = 0.010), and delayed recall (<em>β</em> = 0.167, <em>p</em> = 1.57 × 10⁻³) in all patients with schizophrenia. Additionally, a nominal positive correlation was observed with visual memory (<em>β</em> = 0.124, <em>p</em> = 0.019). In non-TRS patients, the adherence of psychiatrists was significantly positively correlated with delayed recall (<em>β</em> = 0.166, <em>p</em> = 3.17 × 10⁻³) and nominally positively correlated with verbal memory (<em>β</em> = 0.141, <em>p</em> = 0.013) and attention/concentration (<em>β</em> = 0.114, <em>p</em> = 0.044) functions. In contrast, no significant associations were observed between the psychiatrists’ adherence and any memory functions in patients with TRS.</div></div><div><h3>Conclusions</h3><div>These findings suggest that enhancing guideline education for psychiatrists might improve cognitive impairments in patients with schizophrenia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 169-176"},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of mental health care among people bereaved by suicide in Norway: A trajectory analysis","authors":"Sissel Marguerite Bélanger ,&nbsp;Solveig Glestad Christiansen ,&nbsp;Jorid Kalseth ,&nbsp;Silje L. Kaspersen ,&nbsp;Annette Erlangsen ,&nbsp;Anne Reneflot ,&nbsp;Lars Johan Hauge ,&nbsp;Kim Stene-Larsen","doi":"10.1016/j.jpsychires.2025.03.036","DOIUrl":"10.1016/j.jpsychires.2025.03.036","url":null,"abstract":"<div><h3>Background</h3><div>Losing a loved one to suicide is an extremely stressful event that is associated with mental health issues. However, little is known about the health care utilization of those bereaved by suicide. Identifying distinct trajectories of mental health care utilization can help reveal gaps in service provision, barriers to access, and opportunities for targeted interventions.</div></div><div><h3>Aims</h3><div>To uncover distinct patterns of mental health care utilization in association with suicide bereavement and explore sociodemographic factors and subsequent suicide risk associated with these patterns.</div></div><div><h3>Method</h3><div>We analyzed Norwegian population-wide registry data on mental health care utilization at three different levels among 14 781 adults bereaved by suicide from 2010 to 2019 using group-based multi-trajectory modeling to identify groups with distinct mental health care utilization trajectories. Socio-demographic differences between trajectory groups were analyzed in multinomial logistic regression models and the associated risk of suicide was obtained with cox proportional hazards regression models.</div></div><div><h3>Results</h3><div>We identified four distinct trajectories of mental health care utilization. Two distinct groups of individuals bereaved by suicide either rarely contacted mental health care providers (“Low”) or only consulted with general practitioners only (\"GP only\"). In the latter group, the utilization rate increased post-bereavement. One group of bereaved (\"Acute increase\") increased their mental health care utilization significantly after the loss, while another group (\"High\") consistently had a high utilization rate. These groups differed with respect to kinship to the deceased and sociodemographic factors. Individuals in the “GP only” and “High” group had significantly higher risk of suicide when compared to those in the “Low” group.</div></div><div><h3>Conclusions</h3><div>Individuals bereaved by suicide exhibited diverse patterns of mental health care utilization, reflecting a broad spectrum of needs and responses to loss.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 130-137"},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of autism-related symptoms in treatment-resistant schizophrenia: associations with cognitive performance, psychosocial functioning, and neurological soft signs — Clinical evidence and ROC analysis","authors":"Licia Vellucci ,&nbsp;Annarita Barone ,&nbsp;Elisabetta Filomena Buonaguro ,&nbsp;Mariateresa Ciccarelli ,&nbsp;Giuseppe De Simone ,&nbsp;Federica Iannotta ,&nbsp;Marta Matrone ,&nbsp;Benedetta Mazza ,&nbsp;Roberto Vitelli ,&nbsp;Andrea de Bartolomeis ,&nbsp;Felice Iasevoli","doi":"10.1016/j.jpsychires.2025.03.040","DOIUrl":"10.1016/j.jpsychires.2025.03.040","url":null,"abstract":"<div><div>Treatment-resistant schizophrenia (TRS) occurs when symptoms persist despite adequate antipsychotic treatment in terms of both timing and dosage. This severe condition is often overlooked, despite the existence of guidelines, with an average delay of 4–9 years before the introduction of clozapine, the gold standard treatment. We hypothesized that schizophrenia patients with severe autistic symptoms are more prone to develop TRS. To test this, we administered the Positive and Negative Syndrome Scale for Schizophrenia Autism Severity Scale (PAUSS) to 117 patients diagnosed with schizophrenia. Our results revealed that both TRS and clozapine non-responder (CLZ-nR) groups had higher rates of autistic symptoms than non-TRS patients. A machine learning model was developed to examine the relationship between PAUSS scores and TRS, obtaining an accuracy of 0.65 and an AUC of 0.67. Specifically, PAUSS items N6 (“lack of spontaneity and flow of conversation”) and N7 (“stereotypical thinking”) emerged as the most significant factors in the model. In addition, PAUSS was correlated with cognitive and social functions, as well as soft neurological signs, in TRS patients. Autism-related symptoms were found to predict significant variance in motor coordination, verbal fluency, functional ability and soft neurological signs. These results suggest that autism-related symptoms in schizophrenia may define a distinct subgroup with unique neurobiological characteristics.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 119-129"},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-related changes during and after inpatient treatment for refractory somatic symptom disorder or functional neurological symptom disorder: Testing the applicability of a new approach for analyzing routine outcome monitoring data","authors":"Jan Houtveen ,&nbsp;Jonna van Eck van der Sluijs ,&nbsp;Pieter Jan Herremans ,&nbsp;Rinie Geenen","doi":"10.1016/j.jpsychires.2025.03.046","DOIUrl":"10.1016/j.jpsychires.2025.03.046","url":null,"abstract":"<div><div>The aim of the current observational study was to examine changes and the moments of change during and after intensive integrated multidisciplinary inpatient treatment for patients with refractory Somatic Symptom Disorder (SSD) or Functional Neurological symptom Disorder (FND). Observational Routine Outcome Monitoring (ROM) data were analyzed to examine changes during and after tertiary care inpatient treatment. Treatment was a combination of acceptance and commitment therapy, body-oriented mentalization therapy, psychophysiology therapy, and systemic therapy. Fifty-five inpatients were included. Eight domains of health status (RAND-36) and symptoms of psychopathology (BSI) were analyzed with multiple-lag two-phase mixed model regression analysis. In this new approach, a series of regression analyses evaluated changes and the moments of change (i.e., the improvement lag). Graphs were created for each outcome measure to visualize estimates and significances as a function of all lags explored. A Monte Carlo validation study with simulated data demonstrated the applicability of this approach. Regarding the RAND-36, the most pronounced and significant (p &lt; .001) improvements were found for perceived change in health (improvement lag = 25 days), energy/fatigue (lag = 58), and social functioning (lag = 169). For the BSI, improvements were found on the positive symptom distress index (lag = 43), the global severity index (lag = 71), obsession-compulsion (lag = 73), and psychoticism (lag = 133). This study observed increases in mental and physical health and decreases in symptoms of psychopathology during and after inpatient treatment for refractory SSD or FND, with delayed improvements for some outcomes.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 138-145"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local connections enhancement as a neuroprotective strategy against depression recurrence: Insights from structural brain network analysis","authors":"Yang Li ,&nbsp;Hu Xu ,&nbsp;Bo Chen ,&nbsp;Yi Ding ,&nbsp;Yunqian Zhu ,&nbsp;Yang Wang ,&nbsp;Xingbing Chen ,&nbsp;Hui Su","doi":"10.1016/j.jpsychires.2025.03.052","DOIUrl":"10.1016/j.jpsychires.2025.03.052","url":null,"abstract":"<div><h3>Background</h3><div>Depression recurrence significantly impacts patients' well-being and presents a major clinical challenge. Identifying the risk of recurrence during remission could enable early intervention and prevent disease progression.</div></div><div><h3>Methods</h3><div>This study included 115 patients in remission from their first depressive episode and 47 healthy controls (HCs). Participants underwent diffusion tensor imaging (DTI), neuropsychological assessments, and follow-up evaluations every three months over a two-year period. Structural brain networks were constructed using deterministic fiber tracking and graph theory analysis.</div></div><div><h3>Results</h3><div>Non-recurrence patients exhibited significantly higher baseline local connections compared to the recurrence group (t = 8.148; <em>P</em> &lt; 0.001), which emerged as a robust negative predictor of recurrence (AUC = 0.853 [95 % CI: 0.774–0.912]; OR = 0.594 [95 % CI: 0.489–0.722]; <em>P</em> &lt; 0.001). Rich-club connections were inversely correlated with depression severity (r = −0.510; <em>P</em> &lt; 0.001) and duration (r = −0.221; <em>P</em> = 0.018). Additionally, increases in local connections during remission correlated positively with subsequent rich-club connections (r = 0.540; <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Elevated local connections during remission after the first depressive episode significantly reduce the risk of recurrence. This suggests a compensatory neuroprotective mechanism, where enhanced local connections stabilize rich-club connections, thereby maintaining the integrity of the whole-brain network. These findings highlight local connections as a critical factor in preventing depression recurrence and as a potential target for early clinical intervention.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 74-83"},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}