Journal of psychiatric research最新文献

{"title":"Potential role for kynurenine pathway in increased COVID-19 mortality of patients with schizophrenia","authors":"Peng Wang ,&nbsp;Zhen-Ying Li ,&nbsp;Jie Wang ,&nbsp;Kun-Ze Liu ,&nbsp;Ya-Ru Wang ,&nbsp;Qing-Yun Guo ,&nbsp;Shi-Lei Wen ,&nbsp;Pan-Li Ni ,&nbsp;Quan-Peng Zhang ,&nbsp;Tan Wang ,&nbsp;Chun-Mei Gong ,&nbsp;Wei Wan ,&nbsp;Xi-Nan Yi ,&nbsp;Zhi-Jian Ma ,&nbsp;Yun-Qing Li ,&nbsp;Li-Fang Lu ,&nbsp;Ren-Jun Feng","doi":"10.1016/j.jpsychires.2025.02.030","DOIUrl":"10.1016/j.jpsychires.2025.02.030","url":null,"abstract":"<div><div>Schizophrenia (SCZ) is a common psychiatric disorder that has complex pathological mechanisms. During the coronavirus disease 2019 (COVID-19) epidemic, patients with SCZ had substantially higher rates of infection with SARS-CoV-2, the virus that causes COVID-19, as well as higher COVID-19 mortality relative to patients without mental disorders. Previous studies suggested that COVID-19 and SCZ both involve the kynurenine metabolic pathway. This article reviews the characteristics of kynurenine metabolism in COVID-19 and SCZ, and considers the possibility that disordered kynurenine metabolism may be one cause of increased infection and COVID-19 mortality rates in the patients with SCZ. Several possible molecular mechanisms that could be involved in disease pathology are discussed.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 289-295"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between Gulf War Illness and suicidal thoughts and behaviors among Gulf War Era Veterans","authors":"Rachele K. Lipsky ,&nbsp;Drew A. Helmer ,&nbsp;Jean C. Beckham ,&nbsp;Patrick S. Calhoun ,&nbsp;Mary Jo Pugh ,&nbsp;Nathan A. Kimbrel","doi":"10.1016/j.jpsychires.2025.02.039","DOIUrl":"10.1016/j.jpsychires.2025.02.039","url":null,"abstract":"<div><div>The rate of death by suicide is elevated among Veterans of all eras. Chronic symptoms of pain, depression, and sleep disturbances are also common among Veterans, and these symptoms are associated with suicidal thoughts and behaviors. About 25% of the 697,000 Gulf War Era Veterans deployed to the Persian Gulf theater in 1990–1991 remain afflicted with chronic, unexplained symptoms known as Gulf War Illness (GWI). This study used data from a national sample of Gulf War Veterans (N = 1142) who completed a survey of demographic, military, and health information. Multivariable logistic regression models, controlling for confounding variables, tested for associations between deployment, a tri-level categorical variable of GWI (no GWI; moderate GWI; and severe GWI) and suicidal thoughts and behaviors. Deployment was not associated with any suicide related outcome. Moderate and severe GWI remained significantly associated with past year suicidal ideation (moderate GWI: aOR 3.94; 95% CI: 1.55–10.03; severe GWI: aOR 3.66; 95% CI: 1.31–10.20), but they were not associated with suicide attempts. Our findings suggest that the burden and negative impact of the chronic symptoms of GWI may play a role in the occurrence of suicidal ideation in Gulf War Veterans (GWV). Clinicians caring for GWVs should attend to both chronic symptoms, and the elevated risk of suicidal thoughts in this cohort.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 302-307"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and correlates of incentivized response inhibition in schizophrenia and bipolar disorder","authors":"Pooja K. Patel ,&nbsp;Michael F. Green ,&nbsp;Deanna Barch ,&nbsp;Jonathan K. Wynn","doi":"10.1016/j.jpsychires.2025.02.027","DOIUrl":"10.1016/j.jpsychires.2025.02.027","url":null,"abstract":"<div><div>When healthy individuals are incentivized on response inhibition tasks (e.g., Stroop), they recruit additional cognitive resources, enabling them to make faster, more accurate responses. Schizophrenia (SZ) and bipolar disorder (BP) are associated with poor response inhibition, but it is unknown whether SZ and BP show incentive-related improvements to the same degree as healthy controls (HC). To investigate this question, reaction time data from an incentivized Stroop-style task were analyzed from 37 SZ, 26 B P, and 33 H C. We examined: 1) group differences in mean reaction time, 2) group differences in response caution and in rate of processing task-relevant information derived from a computational approach (drift diffusion modeling), and 3) clinical and cognitive correlates of drift diffusion parameters in SZ and BP groups. When incentives were introduced, both HC and BP showed significantly faster response speed, but SZ did not show the same pattern of improvement as a function of incentives. Computational analyses indicated that groups did not significantly differ in response caution, but that both SZ and BP had a slower information processing rate compared to HC. In SZ, slow information processing rate was related to poor cognition; positive and negative symptoms were associated with impairments in information processing rate, but in opposite directions (i.e., increased information processing rate was associated with positive symptom severity; decreased information processing rate was associated with negative symptom severity). Our findings suggest impaired information processing rate may contribute to poor response inhibition in both SZ and BP, whereas response caution is intact in both disorders. However, SZ is distinguished from BP by a failure to enter an overall motivated state and decrease response speed when incentivized.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 282-288"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effect of age on the response to serotonergic and noradrenergic antidepressants: A systematic review, meta-regression and individual participant data pooled analysis” [J. Psychiatr. Res. 183 (2025) 133–143 doi. 10.1016/j.jpsychires.2025.02.013]","authors":"Paolo Ossola ,&nbsp;Maria Lidia Gerra ,&nbsp;Lorenzo Luviè ,&nbsp;Antonio Piacente ,&nbsp;Carlo Marchesi ,&nbsp;Georgios Schoretsanitis ,&nbsp;Jonathan W. Stewart","doi":"10.1016/j.jpsychires.2025.02.029","DOIUrl":"10.1016/j.jpsychires.2025.02.029","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 313-314"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of ECT for depression in patients with and without eating disorders","authors":"Cecilia Gillving,&nbsp;Tor Arnison,&nbsp;Axel Nordenskjöld","doi":"10.1016/j.jpsychires.2025.02.042","DOIUrl":"10.1016/j.jpsychires.2025.02.042","url":null,"abstract":"<div><div>Eating disorders (ED) have a high comorbidity with major depressive disorder (MDD). Antidepressants often lack effect in these patients. While electroconvulsive therapy (ECT) is the most effective treatment for severe MDD, there are no large studies in the ED patient group yet. We aimed to compare the outcome of ECT for MDD in patients with and without eating disorders. We conducted a register-based study for patients with MDD and comorbid ED treated with ECT in Sweden between 2012 and 2023. The outcomes were compared to a matched control group without comorbid ED. The primary outcome was a response to treatment according to the Clinical Global Impression Improvement Scale (CGI-I). Secondary outcomes were remission according to CGI-I and subjective memory complaint. There were 861 patients in the ED group and 1722 in the control group; of these 93.2% were female. The response rate was 58.4% in the ED group and 62.4% in the control group (OR 0.8, 95% CI 0.7–0.9, <em>p</em> &lt; 0.05). The frequency of subjective memory complaints in the ED versus the control group was 25.9% and 24.8%, respectively (OR 1.1, 95% 0.8–1.3 CI, <em>p</em> = 0.6). High response rates after ECT for MDD were found in the ED group but were significantly lower than in the matched control group. Subjective memory complaints did not differ significantly. Further studies are required comparing the outcome of ECT versus alternative treatments among patients with ED complicated by severe MDD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 308-312"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persons at risk for psychosis overestimate social functioning compared to persons with major depressive disorder and community controls","authors":"Joshua E. Mervis ,&nbsp;Franchesca S. Kuhney ,&nbsp;Madisen T. Russell ,&nbsp;Kyle Kinney ,&nbsp;Thomas M. Olino ,&nbsp;Vijay A. Mittal ,&nbsp;Jason Schiffman ,&nbsp;Lauren M. Ellman","doi":"10.1016/j.jpsychires.2025.02.004","DOIUrl":"10.1016/j.jpsychires.2025.02.004","url":null,"abstract":"<div><div>Poor insight is common in persons with psychosis, but treatment can improve insight. Individuals with psychosis who exhibit better insight have better social functioning, reduced negative symptoms, and paradoxically worse depression. There is limited research investigating insight among persons at clinical high risk for psychosis (CHR).</div><div>Understanding the relationship between insight, social functioning, negative symptoms, and depression might inform treatment. We focused on introspective bias (IB), the overestimation or underestimation of social functioning. Persons with CHR (N = 36), Major Depressive Disorder (MDD; N = 164), and community controls (N = 60) were recruited from the Multisite Assessment of Psychosis-risk Study and completed clinical interviews and self-report instruments. The estimation type was operationalized by whether a person was above or below the standardized mean difference between self-reported and interviewer-rated social functioning.</div><div>We hypothesized that 1) persons at CHR would have less depressive symptom severity than those with MDD diagnoses, but more depressive symptom severity than control participants accounting for IB within diagnostic groups, 2) CHR and MDD participants would endorse higher levels of negative symptoms, viewed transdiagnostically (e.g., anhedonia, avolition), than controls but not each other, 3) overestimators would endorse higher levels of negative symptoms and depression than underestimators, 4) CHR participants would have the greatest proportions of overestimators, MDD would have the greatest proportion of underestimators, and control participants would have equal proportions of under- and overestimators.</div><div>Those at CHR had more overestimators, overestimators overall had worse depression and negative symptoms, and diagnostic group membership did not impact the effects of IB on symptoms. This study suggests that IB has clinically relevant correlates but is not a primary treatment target for persons at CHR.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 296-301"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain in multiple sites is associated with depressive symptoms in US adults: A cross-sectional study","authors":"Junjian Zeng ,&nbsp;Zhiqiang Liao ,&nbsp;Aiqing Lin ,&nbsp;Yu Zou ,&nbsp;Yixun Chen ,&nbsp;Zhonghua Liu ,&nbsp;Zhidong Zhou","doi":"10.1016/j.jpsychires.2025.02.033","DOIUrl":"10.1016/j.jpsychires.2025.02.033","url":null,"abstract":"<div><h3>Background</h3><div>Chronic pain poses a significant public health challenge, yet its manifestation in multiple body areas remains insufficiently studied. This study seeks to explore the relationship between chronic pain affecting multiple sites and depression.</div></div><div><h3>Methods</h3><div>We analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2010 regarding chronic pain and depression, employing weighted univariate and multivariate logistic regression analyses to explore the relationship between the number of body sites impacted by chronic pain and depression rates. Furthermore, subgroup analyses were performed to identify possible confounding factors that could affect this relationship.</div></div><div><h3>Results</h3><div>There is a correlation between chronic pain and higher risk of depression (OR 3.821, 95% CI 3.138–4.646, <em>P</em> &lt; 0.001). The multivariable-adjusted observational study indicates that, compared to individuals without chronic pain, the risk of depression is significantly associated with an increasing number of body sites affected by chronic pain. Specifically, when a person experiences chronic pain in five different areas, the risk of depression peaks (OR 16.050, 95% CI 8.723–29.905, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The findings of this study indicate a significant correlation between chronic pain in multiple sites and depressive symptoms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 212-218"},"PeriodicalIF":3.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting mental health disorder onsets with Fibonacci sequencing: A genetic and epigenetic perspective","authors":"Rob G. Sacco ,&nbsp;Bernard B. Beitman ,&nbsp;Terry Marks-Tarlow","doi":"10.1016/j.jpsychires.2025.02.036","DOIUrl":"10.1016/j.jpsychires.2025.02.036","url":null,"abstract":"<div><div>This study explores a novel intersection between molecular biology, genomics, and mathematical modeling to predict the onset patterns of mental health disorders. By investigating the alignment between the Fibonacci sequence and the timing of genetic and epigenetic events, this research seeks to uncover whether these patterns can serve as a predictive model for the onset of disorders such as schizophrenia, bipolar disorder, and major depressive disorder. Leveraging epidemiological data and advanced time-series analysis, the study examines how the temporal progression of molecular markers corresponds to clinical manifestation ages in mental health disorders. Findings indicate that specific ages of disorder onset show significant alignment with Fibonacci harmonics, suggesting a potential natural synchrony within biological processes. This interdisciplinary approach could enhance predictive accuracy, supporting early intervention and personalized mental health strategies, and offering a new perspective on the molecular underpinnings of psychiatric conditions.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 237-243"},"PeriodicalIF":3.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypogyrification in the medial regions of the temporal and occipital lobes in hoarding disorder","authors":"Akira Matsuo ,&nbsp;Hirofumi Tomiyama ,&nbsp;Keitaro Murayama ,&nbsp;Kenta Kato ,&nbsp;Nami Nishida ,&nbsp;Kou Matsukuma ,&nbsp;Makoto Kawahito ,&nbsp;Kana Tsunoda ,&nbsp;Mingi Kang ,&nbsp;Kenta Sashikata ,&nbsp;Osamu Togao ,&nbsp;Koji Yamashita ,&nbsp;Kazufumi Kikuchi ,&nbsp;Tatsuhiro Wada ,&nbsp;Tomohiro Nakao","doi":"10.1016/j.jpsychires.2025.02.040","DOIUrl":"10.1016/j.jpsychires.2025.02.040","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 244-251"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of depression and anxiety with coronary artery plaque among asymptomatic adults: The Miami Heart study (MiHeart) at Baptist Health South Florida","authors":"Tanvi Bafna ,&nbsp;Omar Dzaye ,&nbsp;Zeina Dardari ,&nbsp;Miguel Cainzos-Achirica ,&nbsp;Ron Blankstein ,&nbsp;Theodore Feldman ,&nbsp;Matthew J. Budoff ,&nbsp;Jonathan Fialkow ,&nbsp;Khurram Nasir ,&nbsp;Michael J. Blaha","doi":"10.1016/j.jpsychires.2025.02.037","DOIUrl":"10.1016/j.jpsychires.2025.02.037","url":null,"abstract":"<div><h3>Purpose</h3><div>We investigated the associations of depression and anxiety with the presence of coronary artery plaque amongst a diverse cohort of adults without clinical atherosclerotic cardiovascular disease.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed data from the Miami Heart Study at baseline. Depression was ascertained by the 8-item Patient Health Questionnaire (PHQ-8) with a score ≥10 indicating depression. Anxiety was assessed by the Generalized Anxiety Disorder 7-item (GAD-7) questionnaire with a score ≥10 demonstrating anxiety. Multivariable logistic regression models were used to analyze the association of either depression or anxiety with the presence of any plaque on CCTA. Sensitivity analyses further examined the severity of depressive symptoms, severity of anxiety symptoms, individuals with either depression or anxiety, and individuals with both as predictors of coronary plaque.</div></div><div><h3>Results</h3><div>Of the 2356 individuals (mean age 53.4 ± 6.8 years), 50.4% were men and 47.1% were of Hispanic ethnicity. Depression and anxiety were identified in 143 (6.1%) and 224 (9.5%) of individuals, respectively. CCTA-identified plaque was present in 49.0% of participants with depression and 54.0% of those with anxiety, and the presence of any plaque did not significantly differ when compared to those without depression or without anxiety, respectively. There were no statistically significant associations between depression and plaque (adjusted odds ratio [aOR]: 1.03; 95%CI [0.70, 1.52]; p = 0.891) or between anxiety and plaque (aOR: 1.27; 95%CI [0.93, 1.73]; p = 0.138) in all regression models.</div></div><div><h3>Conclusions</h3><div>Our study did not identify an association of depression, anxiety, their combination, or their severity with coronary plaque on CCTA among a large cohort of asymptomatic adults.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 219-224"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}