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The relevance of endoplasmic reticulum lumen and Anoctamin-8 for major depression: Results from a systems biology study.
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-20 DOI: 10.1016/j.jpsychires.2025.01.039
Sofia Cid de Azevedo, Jacson Gabriel Feiten, Marcelo P Fleck, Marco Antonio Caldieraro
{"title":"The relevance of endoplasmic reticulum lumen and Anoctamin-8 for major depression: Results from a systems biology study.","authors":"Sofia Cid de Azevedo, Jacson Gabriel Feiten, Marcelo P Fleck, Marco Antonio Caldieraro","doi":"10.1016/j.jpsychires.2025.01.039","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.039","url":null,"abstract":"<p><p>Major depressive disorder (MDD) is a highly prevalent and debilitating disorder, yet its pathophysiology has not been fully elucidated. The aim of this study is to identify novel potential proteins and biological processes associated with MDD through a systems biology approach. Original articles involving the measurement of proteins in the blood of patients diagnosed with MDD were selected. Data on the differentially expressed proteins (DEPs) in each article were extracted and imported into R, and the pathfindR package was used to identify the main gene ontology terms involved. Data from the STRING database were combined with the DEPs identified in the original studies to create expanded networks of protein-protein interactions (PPIs). An R script was developed to obtain the five most reliable connections from each DEP and to create the networks, which were visualized through Cytoscape software. Out of 510 articles found, eight that contained all the values necessary for the analysis were selected, including 1112 adult patients with MDD and 864 controls. A total of 240 DEPs were identified, with the most significant gene ontology term being \"endoplasmic reticulum lumen\" (46 DEPs, p-value = 5.5x10<sup>-13</sup>). An extended PPI network was obtained, where Anoctamin-8 was the most central protein. Using systems biology contributed to the interpretation of data obtained in proteomic studies on MDD and expanded the findings of these studies. The combined use of these methodologies can provide new insights into the pathophysiology of psychiatric disorders, identifying novel biomarkers to improve diagnostic, prognostic, and treatment strategies in MDD.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"329-337"},"PeriodicalIF":3.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beliefs about the uncontrollability of emotions and interpersonal needs as predictors of Suicide Crisis Syndrome. 自杀危机症候群的情绪失控与人际需求预测因子。
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-18 DOI: 10.1016/j.jpsychires.2025.01.041
Colmenero-Navarrete Lidia, Salguero José M, García-Sancho Esperanza
{"title":"Beliefs about the uncontrollability of emotions and interpersonal needs as predictors of Suicide Crisis Syndrome.","authors":"Colmenero-Navarrete Lidia, Salguero José M, García-Sancho Esperanza","doi":"10.1016/j.jpsychires.2025.01.041","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.041","url":null,"abstract":"<p><p>Suicide Crisis Syndrome (SCS) is an \"acute\" mental state characterized by intense cognitive and affective dysregulation which aims to explain the psychological processes occurring in the days or hours prior to suicide behavior. SCS has been shown to be able to predict suicide behavior, however, few studies have studied which variables predict it. In this study we examined the predictive role of beliefs about the uncontrollability of emotions and interpersonal needs on SCS. We used a sample of 276 participants (50,4% male), ranging in age from 18 to 77 years, who completed a 4-month follow-up study, to address our hypotheses. Results showed that emotional uncontrollability beliefs and perceived burdensomeness predicted SCS. Furthermore, the perception of burdensomeness at Time 1 mediated the link between uncontrollability beliefs at Time 1 and SCS at Time 2. Clinical implications of these results and future lines of research are discussed.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"312-318"},"PeriodicalIF":3.7,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of social media privacy, internet addiction in adolescents who are victims of sexual abuse and digital awareness in their parents.
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-17 DOI: 10.1016/j.jpsychires.2025.01.030
Sena Aksoy, Serdar Avunduk, Erdal Görkem Gavcar, Ahmet Büber
{"title":"Evaluation of social media privacy, internet addiction in adolescents who are victims of sexual abuse and digital awareness in their parents.","authors":"Sena Aksoy, Serdar Avunduk, Erdal Görkem Gavcar, Ahmet Büber","doi":"10.1016/j.jpsychires.2025.01.030","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.030","url":null,"abstract":"<p><strong>Background: </strong>Childhood sexual abuse is the exploitation of a child by an adult for sexual purposes. Many cases go undetected and can occur across all socioeconomic levels, ages, genders, and regions. With the rise of internet use, abuse is increasingly occurring online, with some online relationships escalating to in-person sexual contact between the victim and offender.</p><p><strong>Objective: </strong>Our study hypothesizes that adolescents with high internet addiction and difficulty protecting their privacy online may be at greater risk for abuse, and that their parents may have low digital awareness.</p><p><strong>Methods: </strong>Adolescents completed the Sociodemographic Data Form, Social Media Privacy Protection Scale, and Young Internet Addiction Scale (short form), while parents completed the Digital Parent Awareness Scale. Statistical analyses were conducted using SPSS version 26.</p><p><strong>Results: </strong>The case group showed higher internet addiction and social media use, while the control group had better social media privacy protection skills. Although not statistically significant, parents in the case group had lower digital awareness. A negative relationship was observed between internet addiction and parental awareness.</p><p><strong>Discussion: </strong>Parental mediation of young people's social media use significantly impacts their privacy management.To prevent abuse, parents must understand the risks of the digital environment and the necessary precautions.</p><p><strong>Limitation: </strong>The primary limitation of this study is the limited sample size, which may restrict the generalizability of the findings.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"368-372"},"PeriodicalIF":3.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular risk and allostatic load in PTSD: The role of cumulative trauma and resilience in affected and trauma-exposed adults.
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-17 DOI: 10.1016/j.jpsychires.2025.01.040
Esmé Jansen van Vuren, Leigh L van den Heuvel, Sian Mj Hemmings, Soraya Seedat
{"title":"Cardiovascular risk and allostatic load in PTSD: The role of cumulative trauma and resilience in affected and trauma-exposed adults.","authors":"Esmé Jansen van Vuren, Leigh L van den Heuvel, Sian Mj Hemmings, Soraya Seedat","doi":"10.1016/j.jpsychires.2025.01.040","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.040","url":null,"abstract":"<p><strong>Background: </strong>The pathophysiology of posttraumatic stress disorder (PTSD) involves dysregulation of stress-sensitive biological systems due to repeated trauma exposure, predisposing individuals to the development of cardiovascular disease (CVD). Allostatic load (AL), an indicator of maladaptive stress responses, could shed light on the underlying biological mechanisms. We determined whether CVD risk and AL were associated with trauma load and resilience in women with PTSD and trauma-exposed controls (TEC).</p><p><strong>Methods: </strong>Adults with PTSD N = 114 and TEC N = 95 were administered the Clinician Administered Posttraumatic Stress Disorder Scale for DSM-5, to assess for current PTSD diagnosis and severity, the Life Events Checklist for DSM-5 for lifetime exposure to potentially traumatic events (cumulative trauma) and the Connor-Davidson Resilience Scale. An AL score was calculated as a sum of dichotomous variables from four physiological systems (neuroendocrine, metabolic, cardiovascular, and inflammatory). CVD risk was assessed with the South African Framingham risk score.</p><p><strong>Results: </strong>In patients with PTSD, cumulative trauma was associated with higher AL (p = 0.04) and CVD risk (p = 0.02). In TEC, AL was inversely associated with resilience (p = 0.04). There was a significant interaction between cumulative trauma and resilience on AL (p = 0.009) in PTSD cases, with a stronger association between cumulative trauma and AL in those with higher resilience.</p><p><strong>Conclusions: </strong>Resilience may have differential detrimental and protective effects on AL in individuals with PTSD and TEC. Cumulative trauma exposure may, independently, increase the likelihood of high AL and CVD risk in PTSD, with resilience moderating this effect. Remaining resilient while experiencing PTSD symptoms may impose a biological strain that could have long-term harmful effects.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"338-346"},"PeriodicalIF":3.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical studies of blood-borne Extracellular vesicles in psychiatry: A systematic review.
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-17 DOI: 10.1016/j.jpsychires.2025.01.037
Mette Elise Tunset, Hanne Haslene-Hox, Jeanette Brun Larsen, Daniel Kondziella, Mona Nygård, Sindre Andre Pedersen, Arne Vaaler, Alicia Llorente
{"title":"Clinical studies of blood-borne Extracellular vesicles in psychiatry: A systematic review.","authors":"Mette Elise Tunset, Hanne Haslene-Hox, Jeanette Brun Larsen, Daniel Kondziella, Mona Nygård, Sindre Andre Pedersen, Arne Vaaler, Alicia Llorente","doi":"10.1016/j.jpsychires.2025.01.037","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.037","url":null,"abstract":"<p><p>Biomarkers for the diagnosis and clinical management of psychiatric disorders are currently lacking. Extracellular vesicles (EVs), lipid membrane-encapsulated vesicles released by cells, hold promise as a source of biomarkers due to their ability to carry molecules that reflect the status of their donor cells and their ubiquitous presence in biofluids. This review examines the literature on EVs in biofluids from psychiatric disorder patients, and discuss how the published studies contribute to our understanding of the pathophysiology of these conditions and to the discovery of potential biomarkers. We analyzed 46 studies on blood-borne EVs; no investigations on cerebrospinal fluid-derived EVs were found. A significant number of studies lacked optimal description of the methodology and/or characterization of the isolated EVs. Moreover, many studies aimed to capture brain-derived EVs, but often capture-proteins with low brain specificity were used. Considering biomarkers, miRNAs were the most investigated molecular type, but based on the studies analyzed it was not possible to identify robust biomarker candidates for the investigated disorders. Additionally, we describe the contribution of EV studies in illuminating the pathophysiology of psychiatric disorders, including research on insulin resistance, inflammation, mitochondrial dysfunction, and the microbiota. We conclude that there is a shortage of studies with detailed methodology description and EV sample characterization in psychiatric research. To exploit the potential of EVs to investigate psychiatric disorders and identify biomarkers more studies and validated protocols using capture proteins with high specificity to brain cells are needed. The review protocol was pre-registered in the PROSPERO database under the registration number CRD42021277534.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"373-390"},"PeriodicalIF":3.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dorsal bed nucleus of the stria terminalis GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice.
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-17 DOI: 10.1016/j.jpsychires.2025.01.034
Wenjing Hu, Qiyuan Wang, Lifang Jiang, Lina Zhang, Huichao Sun, Junying Bao, Xiao Chen, Gaole Yuan, Kai Yan, Yun Liu, Jian Wu, Tao Liu
{"title":"Dorsal bed nucleus of the stria terminalis GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice.","authors":"Wenjing Hu, Qiyuan Wang, Lifang Jiang, Lina Zhang, Huichao Sun, Junying Bao, Xiao Chen, Gaole Yuan, Kai Yan, Yun Liu, Jian Wu, Tao Liu","doi":"10.1016/j.jpsychires.2025.01.034","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.034","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have shown that neurons in the Bed Nucleus of the Stria Terminalis (BNST) respond to stress and play a key role in mental health. However, the cellular bases of BNST in adolescent depression remain elusive.</p><p><strong>Methods: </strong>Male C57BL/6 mice were randomly assigned to the control (Ctrl) or chronic unpredictable stress (CUS) groups. The CUS mice, aged 28 days, were subjected to diverse stressors at various times of the day for 12 days. Depression-like behaviors were assessed through the sucrose preference test (SPT) and tail suspension test (TST). Immunostaining was used to investigate the neural activity and subtypes in the brain. A chemogenetic tool was conducted to examine the role of specific neural activity in CUS-induced depression-like behaviors.</p><p><strong>Results: </strong>CUS led to a significant decrease in preference for sucrose solution in the SPT and increased immobility time in the TST. C-Fos immunostaining showed hyperactivity of the GABAergic neurons within the dorsal BNST (dBNST<sup>GABA</sup>). Chemogenetic activation of dBNST<sup>GABA</sup> neurons increased depression-like behaviors. Conversely, chemogenetic inhibition of dBNST<sup>GABA</sup> neurons led to a decrease in CUS-induced depression.</p><p><strong>Conclusions: </strong>These results suggest that adolescent CUS induces hyperactivity of dBNST<sup>GABA</sup> neurons, subsequently giving rise to depression-like behaviors and that reducing dBNST<sup>GABA</sup> neuronal activity might constitute a novel and efficacious therapeutic approach for adolescent depression.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"347-357"},"PeriodicalIF":3.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SNORD3C, a blood biomarker associated to suicide attempts in patients with anorexia nervosa.
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-16 DOI: 10.1016/j.jpsychires.2025.01.026
Camille Verebi, Nicolas Lebrun, Philibert Duriez, Lucie Adoux, Benjamin Saint-Pierre, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu
{"title":"SNORD3C, a blood biomarker associated to suicide attempts in patients with anorexia nervosa.","authors":"Camille Verebi, Nicolas Lebrun, Philibert Duriez, Lucie Adoux, Benjamin Saint-Pierre, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu","doi":"10.1016/j.jpsychires.2025.01.026","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.026","url":null,"abstract":"<p><p>Anorexia nervosa (AN) is a psychiatric disorder with a high heritability (h<sup>2</sup>∼70%). Despite extensive meta-analysis of genome-wide association studies, the molecular mechanisms underlying genetics of AN and its complications, particularly suicidal behavior, remain unclear. We performed mRNA sequencing on peripheral blood mononuclear cells from 15 patients with AN (5 with a lifetime history of suicide attempts and 10 without). After correcting for multiple testing, we identified dysregulation of several genes, and confirmed our findings in an independent cohort of 34 patients with AN. Our analysis revealed significant dysregulation of several genes, including SNORD3C, which is implicated in vitamin D metabolism. These genes were enriched in RNA metabolism and innate immune pathways. The presence of these dysregulated genes was associated with suicidal behavior in patients with AN. Our findings suggest that SNORD3C and other differentially expressed genes may serve as potential biomarkers for suicidal risk in AN. This study enhances our understanding of the biological pathways involved in the pathogenesis of suicidal behavior in AN, paving the way for future research and potential clinical applications.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"358-367"},"PeriodicalIF":3.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of electroconvulsive therapy on inflammatory markers in patients with severe mental disorders. 电休克治疗对严重精神障碍患者炎症标志物的影响。
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-16 DOI: 10.1016/j.jpsychires.2025.01.036
Simge Seren Kirlioglu Balcioglu, Amine Kilictutan, Duygu Ozer, Oya Guclu, Mustafa Nuray Namli
{"title":"Impact of electroconvulsive therapy on inflammatory markers in patients with severe mental disorders.","authors":"Simge Seren Kirlioglu Balcioglu, Amine Kilictutan, Duygu Ozer, Oya Guclu, Mustafa Nuray Namli","doi":"10.1016/j.jpsychires.2025.01.036","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.036","url":null,"abstract":"<p><strong>Objective: </strong>Evaluation of the effects of electroconvulsive therapy (ECT) on systemic inflammatory markers in patients with severe mental disorders and determination of potential clinical predictors of treatment response.</p><p><strong>Methods: </strong>The current retrospective cohort study included 156 patients with psychotic and mood disorders who underwent ECT. Pre- and post-ECT blood samples were collected to assess inflammatory markers, including C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), and other complete blood count derived indices. Clinical outcomes were measured using the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression Severity (CGI-S).</p><p><strong>Results: </strong>Significant reductions in several inflammatory markers were identified, including NLR, monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), CRP and CRP-albumin ratio, following ECT. Both BPRS and CGI-S scores also showed marked improvement post-ECT. Psychotic presentation was identified as a predictor of greater symptom improvement; changes in inflammatory markers were not significantly correlated with clinical outcomes.</p><p><strong>Conclusion: </strong>ECT can reduce systemic inflammation in patients with severe mental disorders; however, this reduction may not directly correspond to clinical improvement. These findings suggest that inflammation plays a complex role in the therapeutic effects of ECT.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"297-303"},"PeriodicalIF":3.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental health and sociodemographic influences during COVID-19: Longitudinal findings from Iceland. COVID-19期间的心理健康和社会人口影响:冰岛的纵向研究结果。
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-13 DOI: 10.1016/j.jpsychires.2025.01.013
Erla Katrín Jónsdóttir, Auðun Valborgarson, Bryndís Björk Ásgeirsdóttir, RannveigS Sigurvinsdottir
{"title":"Mental health and sociodemographic influences during COVID-19: Longitudinal findings from Iceland.","authors":"Erla Katrín Jónsdóttir, Auðun Valborgarson, Bryndís Björk Ásgeirsdóttir, RannveigS Sigurvinsdottir","doi":"10.1016/j.jpsychires.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.013","url":null,"abstract":"<p><p>The COVID-19 pandemic introduced numerous stressors and challenges that have had profound implications for mental health. This study examined the effects of the pandemic on mental health among Icelandic adults (n = 1766), using longitudinal survey data spanning three waves of data collection from 2019 to 2022. Symptoms of depression, anxiety, and stress increased from the beginning of the pandemic to the second time point, approximately one year into the pandemic, coinciding with reductions in happiness and social support. By the third time point, mental health remained slightly poorer than pre-pandemic levels, even after all COVID-19-related restrictions had been lifted. Unlike some other countries, COVID-19 infections in Iceland did not rise significantly until after the summer of 2021. Overall, participants perceived that the pandemic most adversely affected their social relationships and mental health. Prolonged periods in quarantine were predictive of these perceptions, albeit effect sizes were small. During the pandemic, women and younger participants reported slightly poorer mental health, while social support predicted better mental health outcomes. These results show that large societal stressors can significantly impact the mental health of populations. While social support is a prominent predictor of better mental health, additional variables may be needed to explain these effects fully.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"243-252"},"PeriodicalIF":3.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebral blood flow differences in cognitive disengagement syndrome and attention deficit hyperactivity disorder: Doppler ultrasonography findings. 认知脱离综合征和注意缺陷多动障碍的脑血流差异:多普勒超声检查结果。
IF 3.7 2区 医学
Journal of psychiatric research Pub Date : 2025-01-11 DOI: 10.1016/j.jpsychires.2025.01.024
Ahmet Kursat Karaman, Enes Sarıgedik, Osman Kamer Eryılmaz, Meltem Küçükdağ, İbrahim Feyyaz Naldemir
{"title":"Cerebral blood flow differences in cognitive disengagement syndrome and attention deficit hyperactivity disorder: Doppler ultrasonography findings.","authors":"Ahmet Kursat Karaman, Enes Sarıgedik, Osman Kamer Eryılmaz, Meltem Küçükdağ, İbrahim Feyyaz Naldemir","doi":"10.1016/j.jpsychires.2025.01.024","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.01.024","url":null,"abstract":"<p><strong>Objective: </strong>The present study aims to investigate potential differences in cerebral blood flow between children with Cognitive Disengagement Syndrome (CDS) and those with Attention Deficit Hyperactivity Disorder (ADHD) using Doppler ultrasound.</p><p><strong>Methods: </strong>In this single-center prospective study, we included 24 cases in the ADHD group with CDS symptoms, 29 cases in the ADHD group without CDS symptoms and, 26 children in the healthy controls. The children ranged in age from 6 to 15. Participants were evaluated by diagnostic interviews and standardized measures. Doppler ultrasound was performed to measure peak systolic velocity and blood flow volume (BFV) in the internal carotid (ICA) and vertebral arteries for each participant.</p><p><strong>Results: </strong>The right ICA and total ICA BFVs were significantly lower in the CDS group compared to the ADHD and control groups (p = 0.007 and p = 0.003, respectively). In addition, there was a weak negative correlation between right ICA BFV and CDS scores, suggesting a possible link between reduced cerebral blood flow and CDS symptom severity.</p><p><strong>Conclusion: </strong>This study provides a noteworthy starting point for research on the neurovascular basis of CDS. Our findings indicated significant differences in cerebral blood flow between CDS and ADHD, supporting the idea that CDS is a unique attentional disorder with distinct neurobiological characteristics from ADHD.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"161-165"},"PeriodicalIF":3.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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