Journal of psychiatric research最新文献

{"title":"Corrigendum to “Effects of the continuous theta-burst stimulation on the levels of peripheral blood neuroplasticity biomarkers in people with obsessive-compulsive disorder: Findings from an open-label trial” [J. Psychiatr. Res. 184 (2025) 318–324]","authors":"Julian Maciaszek , Agnieszka Zabłocka , Maksymilian Rejek , Adrianna Senczyszyn , Kamila Rudy , Marta Błoch , Aleksandra Bubniak , Leszczyńska-Nowak Katarzyna , Dominika Jakubczyk , Bogna Bogudzińska , Adam Makszewski , Fila-Pawłowska Karolina , Tomasz Wieczorek , Dorota Szcześniak , Jan Beszłej , Patryk Piotrowski , Błażej Misiak","doi":"10.1016/j.jpsychires.2025.04.028","DOIUrl":"10.1016/j.jpsychires.2025.04.028","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Page 313"},"PeriodicalIF":3.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent profiles of affective temperaments predict suicidal ideation in patients with mood disorders","authors":"Myeongkeun Cho ,&nbsp;C. Hyung Keun Park","doi":"10.1016/j.jpsychires.2025.04.045","DOIUrl":"10.1016/j.jpsychires.2025.04.045","url":null,"abstract":"<div><h3>Background</h3><div>Despite many studies on the relationship between affective temperaments and suicidal ideation, the possible interaction effects of affective temperaments are unknown.</div></div><div><h3>Objectives</h3><div>The present study aimed to find the representative types of Temperament Evaluation of Memphis, Pisa, Paris, and San Diego—Autoquestionnaire (TEMPS-A) profiles and verify their relationship with suicidal ideation.</div></div><div><h3>Methods</h3><div>We analyzed outpatients aged ≥18 years and diagnosed with bipolar I, bipolar II, or major depressive disorder. Latent profile analysis was conducted using TEMPS-A scores, and each profile was named after the sample means of the affective temperaments that were higher than those of the total sample. Patients were assigned into subgroups according to their TEMPS-A scores. Analysis of covariance and post-hoc analyses were conducted to verify the relationship between TEMPS-A profiles and suicidal ideation.</div></div><div><h3>Results</h3><div>Seven types of TEMPS-A profiles were deemed most appropriate. The TEMPS-A profiles had a significant effect on the level of suicidal ideation, whereas mood disorder diagnoses did not significantly affect suicidal ideation nor the strength of the relationship between TEMPS-A profiles and suicidal ideation. Among the TEMPS-A profiles, <em>depressive profile</em>; <em>anxious, cyclothymic, and depressive profile</em>; <em>cyclothymic and hyperthymic profile</em>; <em>cyclothymic, depressive, and irritable profile</em>; and <em>anxious, cyclothymic, hyperthymic, and irritable profile</em> were related to more severe suicidal ideation.</div></div><div><h3>Conclusion</h3><div>Certain affective temperaments may be strongly intercorrelated with one another. TEMPS-A profiles that showed high severity of suicidal ideation met at least one of two conditions: highly depressive temperament, and both highly cyclothymic and hyperthymic temperament.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 348-353"},"PeriodicalIF":3.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding meaning in the meaningless. How narrative meaning-making relates to post-traumatic growth and post-traumatic stress disorder in victims of the Strasbourg Christmas market attack","authors":"Amaury C. Mengin ,&nbsp;Pierre Orselli ,&nbsp;Floriane Lalaus ,&nbsp;Julie Rolling ,&nbsp;Pierre Vidailhet ,&nbsp;Fabrice Berna","doi":"10.1016/j.jpsychires.2025.04.037","DOIUrl":"10.1016/j.jpsychires.2025.04.037","url":null,"abstract":"<div><h3>Background</h3><div>Traumatic events may deeply modify one's views on oneself, others and the world. Finding meaning after traumatic events may be determinant to psychological adjustment and post-traumatic growth.</div></div><div><h3>Objectives</h3><div>Our study aims at investigating the association of narrative meaning-making with post-traumatic growth and post-traumatic stress disorder among individuals exposed to a terrorist attack.</div></div><div><h3>Methods</h3><div>We recruited participants exposed to December 2018 Strasbourg Christmas market attack. The participants narrated three memories: their experience of the terrorist attack (TAM) and two self-defining memories (SDMs). Each narrative was assessed in terms of meaning-making. A total meaning score was calculated to express the cumulated presence of meaning in the three memories. Post-traumatic growth and PTSD were assessed by the Post-traumatic Growth Inventory (PTGI) and the Post-traumatic Checklist for DSM-5 (PCL-5), respectively.</div></div><div><h3>Results</h3><div>Thirty-six participants took part to the study and 108 memories were recorded. Post-traumatic growth was relevantly associated with meaning-making for TAMs (<em>Pr</em> (meaning &gt; no meaning) = 0.993) and with the total meaning score (<em>Pr</em> (β &gt; 0) = 0.998); while PTSD was not (<em>Pr</em> (meaning &gt; no meaning) = 0.941 and = 0.618, respectively). In multivariate analyses, both meaning-making for TAMs (<em>Pr</em> (meaning &gt; no meaning) = 0.984) and the total meaning score (<em>Pr</em> (meaning &gt; no meaning) = 0.976) remained associated with post-traumatic growth.</div></div><div><h3>Conclusions</h3><div>A general meaning-making ability after striking life-events may contribute to the emergence of post-traumatic growth after a traumatic event. Our findings suggest new directions emphasizing on meaning-making in trauma-focused therapies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 354-363"},"PeriodicalIF":3.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of racism as a social determinant of suicidality among young adolescents in the United States: An investigation using the Adolescent Brain Cognitive Development Study","authors":"Bethany M. Wood,&nbsp;Angela Hall,&nbsp;Philip Baiden","doi":"10.1016/j.jpsychires.2025.04.043","DOIUrl":"10.1016/j.jpsychires.2025.04.043","url":null,"abstract":"<div><div>Although cross-sectional studies have investigated the effects of perceived racial discrimination on suicidality among adolescents, few studies have examined the effects of risk of racism on suicidality among young adolescents using longitudinal data. This study investigated the association between the risk of racism and suicidality among young adolescents. Data for this study came from the Adolescent Brain Cognitive Development (ABCD) study (2017–2020). The sample (n = 10,301) of adolescents aged 11–12 was analyzed with risk of racism at Wave 1 as the main explanatory variable and suicidality at Wave 2 as the outcome variable. The main analysis involves the use of binary logistic regression. Of the 10,301 young adolescents examined, 13.01 % reported experiencing suicidality, 54.58 % were at low risk of racism, 42.54 % were at moderate risk of racism, and 2.88 % were at high risk of racism. Controlling for demographic characteristics, risk and protective factors, the odds of experiencing suicidality were 1.69 times higher for young adolescents at high risk of racism [AOR = 1.69, 95 % CI = 1.23, 2.32] when compared to their counterparts at low risk of racism. Parental acceptance and monitoring emerged as protective factors against the detrimental effects of racism on suicidality. The findings of this study demonstrate that racial discrimination significantly contributes to suicidality. There is the need for targeted interventions and anti-racist policies to combat racism and promote protective familial relationships to mitigate young adolescent suicidality.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 364-372"},"PeriodicalIF":3.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pretreatment anhedonia as a predictor of exposure-based anxiety treatment outcomes","authors":"Matthew Mattoni ,&nbsp;Iris Ka-Yi Chat ,&nbsp;Lily A. Brown ,&nbsp;Marin Kautz","doi":"10.1016/j.jpsychires.2025.04.036","DOIUrl":"10.1016/j.jpsychires.2025.04.036","url":null,"abstract":"<div><div>Reward processes can reinforce extinction learning and aide cognitive processes involved with inhibitory learning. Anhedonia, characterized by deficits in reward incentivization, hedonic response, and learning, may therefore predict worse treatment outcomes. The current study examined associations between pretreatment self-reported anhedonia and several measures of anxiety symptom severity and treatment outcomes in a naturalistic exposure-based treatment setting. We used multilevel models to examine the relationship between pretreatment anhedonia with change in general treatment response and disorder-specific symptoms for obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder (PD). Consistent with hypotheses, pretreatment anhedonia severity was associated with higher pretreatment anxiety symptom severity across all measures. However, inconsistent with hypotheses, higher anhedonia scores were associated with greater symptom improvement across treatment for OCD, GAD, and PD, and had no significant relationships with diagnosis-general outcome measures, PTSD symptoms, or SAD symptoms. In sensitivity analyses including number of sessions, higher anhedonia was associated with more sessions across treatment and anhedonia no longer significantly predicted OCD or GAD treatment outcomes when controlling for treatment dose. Together, findings suggest that individuals with higher pretreatment anhedonia still respond to exposure therapy for anxiety disorders, but may require more sessions. More broadly, results highlight challenges in translating laboratory research to naturalistic clinical settings and the need for intensive longitudinal studies that can assess the role of reward processes in exposure therapy.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 305-312"},"PeriodicalIF":3.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of change in insomnia on change in pandemic paranoia: a longitudinal moderated-mediation model in an international sample","authors":"Eric M.J. Morris ,&nbsp;Jessica Kingston ,&nbsp;Lyn Ellett ,&nbsp;Tania Lincoln ,&nbsp;Brandon A. Gaudiano ,&nbsp;Suzanne H. So","doi":"10.1016/j.jpsychires.2025.04.042","DOIUrl":"10.1016/j.jpsychires.2025.04.042","url":null,"abstract":"<div><div>The impact of mistrust of others during a pandemic is an important consideration for public health interventions. Pandemic paranoia is a particular form of persecutory thinking characterised by mistrust and suspicion towards other people specifically due to a pandemic. Pandemic paranoia is heightened among those with a persecutory thinking tendency. We examined the longitudinal relationship between insomnia and pandemic paranoia, with anxiety, depression, and worry as mediators and persecutory thinking as moderator. A longitudinal online survey design was utilized involving an international sample (N = 715) across two timepoints, 12 weeks apart. A moderated mediation model was tested, assessing the effect of change in insomnia on change in pandemic paranoia with changes in anxiety, depression and worry as mediators. The effect of persecutory thinking as a moderator was then tested on the above paths in relation to insomnia. Changes in insomnia predicted changes in pandemic paranoia. Change in anxiety was a significant mediator of insomnia's effects on pandemic paranoia: this indirect pathway was moderated by persecutory thinking. Changes in worry and depression were not significant mediators. Our findings indicate that insomnia influences pandemic paranoia, indirectly through anxiety; persecutory thinking plays a consequential role in these relationships. These findings suggest that special attention should be given to mitigation efforts during pandemics to promote sleep health in individuals with pre-existing vulnerabilities, such as persecutory thinking styles.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 341-347"},"PeriodicalIF":3.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young people's social withdrawal intention during COVID-19 in Hong Kong: A three-wave longitudinal study","authors":"Tim M.H. Li ,&nbsp;Shimin Zhu ,&nbsp;Paul W.C. Wong","doi":"10.1016/j.jpsychires.2025.04.034","DOIUrl":"10.1016/j.jpsychires.2025.04.034","url":null,"abstract":"<div><div>Worldwide physical distancing measures and lockdowns might have triggered and normalised <em>hikikomori</em> or prolonged social withdrawal behaviour especially among young people. The study aimed to examine the potential contributing COVID-related, psychological, family and school factors that related to one's intention to social withdrawal among young people during semi-lockdowns in Hong Kong. A three-wave longitudinal survey was conducted between June 2020 and June 2021. Mixed-effects logistic regression analyses were performed to investigate the association of COVID-related, psychological, and family and school factors with social withdrawal intention. 632 young people aged 10–20 years from 11 schools completed baseline and follow-up measures. The response rate was 83.05 %. At follow-ups, 39.40 % of the respondents reported to have social withdrawal intention. 37.18 % of the respondents felt helpless about COVID-19. The regression models showed loneliness, mother working from home, and hopelessness about COVID-19 at baseline were positive associated with persistent social withdrawal intention at follow-ups. Father working from home at baseline, better school bonding, and better family environment at the second wave were negatively associated with social withdrawal intention. Early identification of young people with poor psychological well-being, especially loneliness, and intention for being socially withdrawn should become a prioritised research and service focus in the post-COVID-19 period.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 314-321"},"PeriodicalIF":3.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental disorders and sexual orientation in college students across 13 countries of differing levels of LGBTQ+ acceptance","authors":"Roberto Rentería ,&nbsp;Claes Andersson ,&nbsp;Marcus Bendtsen ,&nbsp;Philippe Mortier ,&nbsp;Randy P. Auerbach ,&nbsp;Jason Bantjes ,&nbsp;Harald Baumeister ,&nbsp;Anne H. Berman ,&nbsp;Erik Bootsma ,&nbsp;Ronny Bruffaerts ,&nbsp;Irina F. Cohut ,&nbsp;Marcelo A. Crockett ,&nbsp;Pim Cuijpers ,&nbsp;Oana A. David ,&nbsp;David D. Ebert ,&nbsp;Raúl A. Gutierrez-García ,&nbsp;Penelope A. Hasking ,&nbsp;Xanthe Hunt ,&nbsp;Petra Hurks ,&nbsp;Mathilde M. Husky ,&nbsp;Wouter Voorspoels","doi":"10.1016/j.jpsychires.2025.04.021","DOIUrl":"10.1016/j.jpsychires.2025.04.021","url":null,"abstract":"<div><div>Mental health disparities have been reported among sexual minority individuals; minority stress theory posits that such disparities are a result of stigma and discrimination. We estimated the prevalence of mental disorders across sexual orientation groups among first-year college students and whether differences across sexual orientation groups varied by gender and country-level LGBTQ+ (lesbian, gay, bisexual, transgender, queer) social acceptance. Using data (<em>N</em> = 53,175; 13 countries) from the World Mental Health Surveys International College Surveys, we performed multilevel logistic regressions to estimate the associations between sexual orientation (i.e., heterosexual, heterosexual with same-gender attraction [SGA], gay/lesbian, bisexual, asexual, questioning, and other) and five twelve-month DSM-5 disorders (major depressive disorder, generalized anxiety disorder, panic disorder, alcohol use disorder, drug use disorder). Heterosexual students with SGA (AORs 1.30–2.15), gay/lesbian (AORs 1.49–2.70), bisexual (AORs 2.26–3.49), questioning (AORs 1.38–2.04), and “other” (AORs 1.76–2.94) students had higher odds of all disorders compared to heterosexual students with no SGA; asexual students did not. Significant interactions with gender show that the gender difference in prevalence was greater among bisexual individuals for most disorders and among all sexual minorities (except “other”) for drug use disorder. Significant interactions with country level LGBT+ social acceptance showed some sexual minority groups had lower odds (AORs 0.83–0.95) of disorder as country-level acceptance increased. These findings provide further evidence of mental disorder disparities across a wide range of sexual orientations and how these disparities vary by gender and societal LGBTQ+ acceptance in students from diverse countries.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 331-340"},"PeriodicalIF":3.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain functional changes in juvenile delinquents: a preliminary meta-analysis","authors":"Yong-ming Wang ,&nbsp;Jia-sheng Yang ,&nbsp;Xin-qi Liu ,&nbsp;Qing-wen Bie ,&nbsp;Yu-shan Xie ,&nbsp;Meng Zhang ,&nbsp;Lu-yang Tao ,&nbsp;Xi-ping Chen","doi":"10.1016/j.jpsychires.2025.04.032","DOIUrl":"10.1016/j.jpsychires.2025.04.032","url":null,"abstract":"<div><h3>Background</h3><div>Juvenile delinquency is a serious social issue that poses significant challenges to public safety and mental health systems. However, the neurophysiological mechanisms underlying delinquent behaviour in juveniles remain unclear. In this meta-analysis, we aimed to investigate the functional brain characteristics during resting-state and task-based conditions in juvenile offenders.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in PubMed, Web of Science and MEDLINE, focusing on whole-brain resting-state and task-based functional magnetic resonance imaging (fMRI) studies examining brain activation patterns in juvenile delinquents compared with controls.</div></div><div><h3>Results</h3><div>Six task-based fMRI studies were incorporated into the meta-analysis. Our findings revealed increased activation in juvenile delinquents in the left medial orbital part of the superior frontal gyrus (SFG), amygdala and cerebellum vermis VI region across these task-based fMRI studies, and increased activation in the left medial orbital part of the SFG and vermis VI region in studies using emotional tasks. The other five resting-state fMRI studies reported different indicators. Therefore, no meta-analysis was performed on the resting-state data.</div></div><div><h3>Conclusion</h3><div>These findings suggest that overactivation in the fronto-amygdala-cerebellar circuit may be a key neurophysiological basis for impaired emotional and behavioural regulation, as well as increased violent behaviour in juvenile offenders.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 297-304"},"PeriodicalIF":3.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of early-life antibiotic use on emotional and behavioral development trajectories in preschool children","authors":"Lu Chen ,&nbsp;Penggui Wu ,&nbsp;Juan Tong ,&nbsp;Shuangqin Yan ,&nbsp;Guopeng Gao ,&nbsp;Fangbiao Tao ,&nbsp;Kun Huang","doi":"10.1016/j.jpsychires.2025.04.031","DOIUrl":"10.1016/j.jpsychires.2025.04.031","url":null,"abstract":"<div><h3>Background</h3><div>Limited research exists on the link between antibiotic use and emotion and behavior, particularly the lack of continuous emotional and behavioral assessment. Emotions and behaviors reflect key modifiable dimensions of brain function and evolve during childhood growth and development. This paper aimed to examine the antibiotic use (yes/no), categories and duration in association with preschool children's emotional and behavioral development trajectory.</div></div><div><h3>Methods</h3><div>Based on Ma'anshan-Anhui Birth Cohort, 1147 mother-child pairs were included in the study. Parents or guardians reported the children's antibiotic use before age 3, including whether antibiotics were used and the types and duration of antibiotics use. The trajectories of children's emotional and behavioral development were fitted using scores from the Strengths and Difficulties Questionnaire (SDQ) at 48, 60, and 72 months.</div></div><div><h3>Results</h3><div>A total of 23.3 % (268/1147) of children had used antibiotics in the past three months. Children's antibiotic use significantly related with high level of hyperactivity. The use of β-lactam antibiotics, especially non-penicillin, was associated with the risk of high level hyperactivity at a dose-response pattern in duration. Children's combined use of β-lactam and macrolides was related with increased risk of high level hyperactivity, total difficulties and emotional symptoms.</div></div><div><h3>Conclusions</h3><div>Children's antibiotic use before age 3 is observed to be associated with hyperactivity development, especially using β-lactam antibiotics with a relatively long duration. The combined use of β-lactam and macrolides may increase the development of hyperactivity, total difficulties and emotional symptoms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 244-251"},"PeriodicalIF":3.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}