Journal of psychiatric research最新文献

{"title":"Reduced peripheral BDNF levels are associated with suicide attempts across various psychiatric disorders: A systematic review and meta-analysis.","authors":"Srishti Gupta, Pooja Singh, Rohit Verma, Sachit Anand, Chittaranjan Behera","doi":"10.1016/j.jpsychires.2026.10.042","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2026.10.042","url":null,"abstract":"<p><strong>Background: </strong>Brain-derived neurotrophic factor (BDNF) is a crucial protein marker involved in neurogenesis and synaptic plasticity. Its role in suicidal behaviour has been widely implicated with inconsistent findings across diverse studies. This systematic review and meta-analysis evaluated the peripheral BDNF levels among psychiatric patients with a history of suicide attempt (SA) compared to psychiatric controls (PCs) without SA.</p><p><strong>Methods: </strong>PubMed, Web of Science, and EMBASE were systematically searched as per the defined study protocol prospectively registered in PROSPERO [CRD420261412668]. A random-effects (RE) model was used to pool standardised mean differences (SMDs) and 95% confidence intervals (CIs). Subgroup analyses, meta-regression, sensitivity analyses, and publication bias assessments were also performed to explore sources of heterogeneity.</p><p><strong>Results: </strong>A total of 20 studies, including 667 SA and 952 PC, were quantitatively pooled. We found significantly lower peripheral BDNF levels in SA than PC [SMD = -0.26; 95% CI = -0.43,-0.09; p = 0.002]. During subgroup analysis, significant associations were found in plasma samples among depressed patients, medication-naïve/free and medicated patients, recent SA, and in both fasting and non-fasting samples. However, no significant subgroup differences were observed. Additionally, meta-regression analysis did not reveal significant moderators affecting the pooled estimates, and the findings were robust in sensitivity analyses, with no evidence of publication bias.</p><p><strong>Conclusion: </strong>Peripheral BDNF levels are significantly lower in psychiatric patients with a lifetime history of SA across diverse clinical and methodological settings. These findings suggest a potential role for BDNF as a transdiagnostic biological correlate of suicide attempts.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"204 ","pages":"284-294"},"PeriodicalIF":3.6,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149269318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor: Methodological considerations regarding confirmatory claims and multiple comparisons in the PANDORA trial symptom-remission analysis.","authors":"Maria Luca, Alessandro Serretti, Stefano Barlati, Antonina Luca, Lisa Buson, Valentina Menesello, Anna Magistrali, Rosana Carvalho Silva, Giulia Perusi, Gabriele Nibbio, Stefano Bignotti, Giovanni Battista Tura, Antonio Vita, Filippo Drago, Raffaele Ferri, Massimo Gennarelli, Alessandra Minelli","doi":"10.1016/j.jpsychires.2026.10.036","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2026.10.036","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149269348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The journey of patients with problematic alcohol use and at risk of Korsakoff Syndrome: A PRISMA scoping review.","authors":"W Kramer, J J M Roelofs, W E Swildens, S Winters, R J J Gobbens","doi":"10.1016/j.jpsychires.2026.10.037","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2026.10.037","url":null,"abstract":"<p><strong>Objective: </strong>Patients with problematic alcohol use and increased risk of Korsakoff Syndrome (KS) often do not receive timely or appropriate care. Professionals experience difficulties in diagnosing, treating, and guiding this target group. This scoping review aims to map the patient journey of individuals with problematic alcohol use who may be at risk of alcohol-related brain damage or KS.</p><p><strong>Methods: </strong>This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). The search strategy included MeSH and title/abstract terms related to \"problematic alcohol use\", \"Wernicke encephalopathy\", \"patient journey\", and \"experiences/perspectives\". CINAHL, MedLine, and Cochrane were searched (April 18th, 2025) for English and Dutch publications (2015-2025), without restrictions on article type. Records were deduplicated and imported into Rayyan. Two independent reviewers screened titles/abstracts. Full texts were screened when inclusion criteria were met. Discrepancies were resolved through consensus. Key findings were extracted.</p><p><strong>Results: </strong>The search yielded 3171 records. 59 articles were included. Literature suggests that patient journeys among individuals with problematic alcohol use who may be at increased risk of KS are heterogeneous and often involve cycles of hospitalization, detoxification, community care, and relapse-related admissions. Commonly reported barriers included stigma, fragmented care pathways, waiting lists, and limited recognition of alcohol-related brain damage, Wernicke Encephalopathy, and KS. Several studies reported traumatic life events as potential antecedents to problematic alcohol use. Some patients at risk of KS or living with KS, may exhibit care-avoidant behaviour and require non-stigmatizing, personalized, and integrated care to improve engagement.</p><p><strong>Conclusions: </strong>The literature suggests that improving knowledge, reducing fragmentation, and strengthening multidisciplinary collaboration may contribute to improving the patient journey. Literature also indicates that integrated multidisciplinary and person-centred approaches may improve recognition, coordination of care and support for individuals at risk of KS. However, the evidence base remains heterogeneous and largely indirect. Longitudinal and intervention studies are needed to evaluate effectiveness and establish causal relationships.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"204 ","pages":"258-276"},"PeriodicalIF":3.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149269293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of insecure attachment style on food addiction is mediated by alexithymia severity: A cross-sectional study in a large sample of individuals with obesity.","authors":"Emanuela Bianciardi, Claudio Imperatori, Alberto Siracusano, Marco Innamorati, Paolo Gentileschi, Mariantonietta Fabbricatore, Cinzia Niolu","doi":"10.1016/j.jpsychires.2026.09.030","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2026.09.030","url":null,"abstract":"<p><strong>Objective: </strong>Food addiction (FA) has emerged as a potential contributor to dysfunctional eating behaviors and obesity, yet its etiopathological underpinnings remain poorly understood. Insecure attachment styles and alexithymia are considered risk factors for feeding and eating disorders. This study aimed to investigate whether alexithymia mediates the relationship between insecure attachment styles and food addiction symptoms in individuals with obesity.</p><p><strong>Method: </strong>We conducted a cross-sectional study involving 770 adults with obesity (BMI ≥ 30 kg/m²) undergoing preoperative psychosocial evaluation for bariatric surgery. Participants underwent a comprehensive clinical psychiatric assessment and completed validated self-report measures assessing attachment style (ASQ), alexithymia (TAS-20), and FA symptoms (YFAS). Two mediation models were tested, controlling for sociodemographic and clinical covariates.</p><p><strong>Results: </strong>Both avoidant and anxious attachment styles were significantly associated with greater alexithymia (rho = 0.483 and rho = 0.564, p < 0.001) and FA symptoms (rho = 0.293 and rho = 0.413, p < 0.001). Mediation analyses showed that alexithymia significantly mediated the association between both attachment styles and FA symptoms (avoidant attachment: B = 0.021, CI [0.015; 0.028]; anxious attachment: B = 0.019, CI [0.012; 0.026]).</p><p><strong>Conclusion: </strong>This study provided novel evidence that alexithymia may serve as a key psychological mechanism linking insecure attachment patterns to food addiction in individuals with obesity. Interventions targeting emotional awareness and regulation may enhance treatment outcomes for FA, particularly in patients presenting with attachment insecurity and alexithymic traits.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"204 ","pages":"277-283"},"PeriodicalIF":3.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149269361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining multilevel resilience as a moderator of associations between gendered racial microaggressions and postpartum mental health and functioning.","authors":"Frances M Howell, Natalie Boychuk, Latima Collins, Melissa J Dupont-Reyes, Sarah Nowlin, Lisa Levine, Elizabeth A Howell, Teresa Janevic","doi":"10.1016/j.jpsychires.2026.04.002","DOIUrl":"10.1016/j.jpsychires.2026.04.002","url":null,"abstract":"<p><p>The United States is currently facing a maternal health crisis, and mental health issues are a leading preventable cause of maternal mortality. We assessed the influence of resilience on the relationship between gendered racial microaggressions (GRM) and postpartum depressive symptoms and functioning. We analyzed data among 265 postpartum Global Majority participants across four Philadelphia and New York hospitals. We administered the adapted Gendered Racial Microaggressions Scale (α = 0.97) to participants before discharge. Postpartum depressive symptoms, postpartum functioning, and resilience were assessed at 3 months postpartum using the Edinburgh Postnatal Depression Scale, the Patient-Reported Outcomes Measurement Information System Global Short Form, the Collective Efficacy Scale, and the Connor-Davidson Resilience Scale, respectively. Multilinear regressions tested the associations between GRM and postpartum depressive symptoms and functioning. Moderation analysis examined how community and personal resilience changed the relationship between GRM and postpartum depressive symptoms and functioning. Experiencing GRM during obstetric care was associated with postpartum depressive symptoms and lower postpartum functioning symptoms. Personal resilience moderated the association between GRM and postpartum functioning; this moderation was not observed for postpartum depressive symptoms. Community resilience did not moderate the association between GRM or postpartum depression and functioning symptoms. Gendered racial microaggressions, in obstetric contexts, harm postpartum mental and physical health. However, personal resilience may mitigate the impact of racism in obstetric care on postpartum health.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":" ","pages":"715-722"},"PeriodicalIF":3.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13288938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of anxiety and depression in children and adolescents with inflammatory bowel disease: Prevalence and association","authors":"Tingting Xu ,&nbsp;Yanhong Chen ,&nbsp;Qiqi Shen ,&nbsp;Sichao Dai ,&nbsp;Haohao Yan ,&nbsp;Jianjuan Ren","doi":"10.1016/j.jpsychires.2026.02.008","DOIUrl":"10.1016/j.jpsychires.2026.02.008","url":null,"abstract":"<div><h3>Background</h3><div>Anxiety and depression are prevalent comorbidities in patients with inflammatory bowel disease (IBD). However, their prevalence and impact in children and adolescents with IBD remain poorly defined. This meta-analysis aimed (i) to estimate the prevalence of anxiety and depression in this population and (ii) to explore the association between these psychological issues and IBD.</div></div><div><h3>Methods</h3><div>A thorough search of Embase, Web of Science, and PubMed from inception through February 1, 2025, was conducted. Two authors independently extracted data and assessed study quality. Pooled prevalence estimates, odds ratios (ORs), and hazard ratios (HRs) were calculated using a random-effects model. Subgroup and sensitivity analyses were performed to examine sources of heterogeneity and assess result robustness.</div></div><div><h3>Results</h3><div>The meta-analysis included 48 studies with 189,032 children and adolescents with IBD. Pooled prevalence estimates were as follows: anxiety symptoms (12%; 95% confidence interval [CI]: 7%–17%; k [number of studies] = 14; n [number of subjects] = 1574); anxiety disorders (9%; 95% CI: 5%–14%; k = 6; n = 168,378); depressive symptoms (15%; 95% CI: 11%–19%; k = 35; n = 4426); and depressive disorder (8%; 95% CI: 5%–11%; k = 7; n = 168,475). Pooled HRs indicated a significantly higher risk of developing anxiety and depressive disorders in this population, with HRs of 1.95 and 1.65, respectively.</div></div><div><h3>Conclusions</h3><div>Children and adolescents with IBD face a substantial burden of anxiety and depression. Routine mental health screening is essential for early intervention and comprehensive management of these comorbidities.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 78-89"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of problematic smartphone use, depression, and anxiety, and their relationships with mindfulness among medical students","authors":"Zhihan Chen ,&nbsp;Junni Bai ,&nbsp;Yunan Hu ,&nbsp;Bo Zhou ,&nbsp;Yang Wang","doi":"10.1016/j.jpsychires.2026.02.014","DOIUrl":"10.1016/j.jpsychires.2026.02.014","url":null,"abstract":"<div><div>Previous studies have uncovered a negative correlation between problematic smartphone use (PSU) and both depression and anxiety, yet the investigation of PSU with depression and anxiety on a symptomatic level among medical students remains limited. This study aims to analyze the network structure of PSU and its relation to symptoms of depression and anxiety, as well as examine the role of mindfulness among these factors. A sample of 456 medical students was assessed using the Smartphone Addiction Scale - Short Version (SAS-SV), the nine-item Patient Health Questionnaire (PHQ-9), the seven-item Generalized Anxiety Disorder Scale (GAD-7), and the Mindful Attention Awareness Scale (MAAS). Network analysis was employed to build the network structure and to identify central and bridge symptoms with centrality indices. The analysis revealed that preoccupation with smartphone and withdrawal symptoms serve as central symptoms in the development of PSU among medical students. Excessive use and fatigue emerged as bridge symptoms linking PSU to depression, while excessive use and restlessness were identified as bridge symptoms connecting PSU with anxiety. Mindfulness exhibited a negative association with numerous symptoms across PSU, depression, and anxiety. The findings indicate that targeting preoccupation with smartphone and withdrawal symptoms might prevent the development of PSU among medical students. Targeting excessive use may be essential in preventing the progression of PSU to depression and anxiety. Given the backgrounds of medical students, online mindfulness interventions could be a viable approach to mitigate PSU and improve mental health among them.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 97-105"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of the bidirectional relationship between psychosis and loneliness","authors":"Ana Ortiz-Tallo ,&nbsp;Ana Izquierdo ,&nbsp;Ana Calvo ,&nbsp;Elvira Lara ,&nbsp;José Luis Ayuso-Mateos ,&nbsp;María Cabello","doi":"10.1016/j.jpsychires.2026.02.018","DOIUrl":"10.1016/j.jpsychires.2026.02.018","url":null,"abstract":"<div><h3>Background</h3><div>and hypothesis: Loneliness, defined as a subjective feeling of isolation, has been significantly correlated with psychotic experiences in general and clinical populations, although less is known about the direction of this relationship. This paper aims to systematically review the longitudinal relationship between loneliness and psychosis spectrum continuum, addressing two fundamental questions: (1) is loneliness a risk factor for the development of psychosis, and (2) does psychosis increase the risk of experiencing loneliness?</div></div><div><h3>Study design</h3><div>A comprehensive search of 5 electronic databases yielded a total of 4386 records, from which 10 observational studies were finally included.</div></div><div><h3>Study results</h3><div>Six studies investigated the first research question, and all of them identified a significant association between loneliness and the subsequent incidence of psychosis (question 1). Conversely, 4 studies explored the second research question, with 3 suggesting that individuals within the psychosis spectrum may face heightened susceptibility to loneliness (question 2). The remaining study, conducted during the COVID-19 pandemic, did not yield significant findings. Assessment of methodological quality indicated predominantly moderate-to-high-quality studies.</div></div><div><h3>Conclusions</h3><div>The findings underscore the need for further research, particularly longitudinal prospective studies, to clarify whether the observed association between loneliness and psychosis is direct or whether it is instead moderated or mediated by other variables. Overall, the available evidence provides stronger support for loneliness as a potential risk factor for the onset of psychosis, although the number of longitudinal studies addressing this question remains very limited. Addressing these gaps in knowledge could inform the development of targeted prevention programs and interventions for people with psychotic spectrum disorders.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 115-122"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating levels of glial cell line-derived neurotrophic factor in bipolar disorder: A meta-analysis of case-control studies and efficacy of therapeutic interventions","authors":"Omran Davarinejad ,&nbsp;Saeid Komasi ,&nbsp;Mohammad-Taher Moradi ,&nbsp;Fatemeh Kazemisafa","doi":"10.1016/j.jpsychires.2026.02.005","DOIUrl":"10.1016/j.jpsychires.2026.02.005","url":null,"abstract":"<div><h3>Background</h3><div>Bipolar disorder (BD) is a chronic and debilitating mental illness characterized by alternating episodes of mania and depression, affecting approximately 5-6% of the global population. Despite extensive research, the underlying pathophysiology of BD remains poorly understood, necessitating further exploration of potential biomarkers. This meta-analysis investigates peripheral levels of glial cell line-derived neurotrophic factor (GDNF) to evaluate its utility as a biomarker in individuals with BD.</div></div><div><h3>Methods</h3><div>We systematically searched four international databases, identifying 13 case-control studies (825 patients with BD vs. 885 healthy controls) and 4 clinical trials encompassing 153 patients with BD. The study adhered to PRISMA guidelines and employed rigorous quality assessment tools, including the Newcastle-Ottawa Scale for observational studies and the Cochrane Risk of Bias tool for clinical trials.</div></div><div><h3>Results</h3><div>The analysis revealed a pooled standardized mean difference of d = −0.81 [CI: 1.41 to −0.22], p = 0.007. However, extreme heterogeneity (I² &gt; 96%) and publication bias preclude reliable interpretation of this estimate. Furthermore, the meta-regression analyses were significant for illness duration, YMRS score, and year of study. Subgroup analysis showed significant estimates for blood sample, mania episode, and Asian region. Although treatment interventions increased GDNF levels, these changes were not statistically significant (<em>d</em> = 0.12, [95% CI: 0.20 to 0.44], <em>p</em> = 0.463). High heterogeneity was observed across studies, indicating substantial variability in study designs and participant characteristics.</div></div><div><h3>Conclusion</h3><div>The literature provides preliminary, highly heterogeneous evidence suggestive of altered GDNF levels in BD, primarily within serum during mania. The plasma-serum discrepancy highlights a major methodological confounder (platelet GDNF release), and the significant heterogeneity and publication bias preclude a reliable estimate of the true effect size. GDNF cannot be considered a disorder-specific biomarker for BD, as similar alterations are reported in major depression and schizophrenia. Future research must prioritize plasma measurements, standardized protocols, and longitudinal designs in medication-naïve cohorts to clarify whether GDNF acts as a state-dependent marker of acute mood episodes within a transdiagnostic framework.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 30-39"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-limited model of an evidence-based telemental health intervention in a graduate student mental health program","authors":"Suza C. Scalora ,&nbsp;Stephanie Lechich ,&nbsp;Alyssa DePasquale ,&nbsp;Helene Geramian ,&nbsp;Katharine Blodget ,&nbsp;Irena Ilieva ,&nbsp;Andrea Temkin-Yu ,&nbsp;Patricia Marino","doi":"10.1016/j.jpsychires.2026.01.062","DOIUrl":"10.1016/j.jpsychires.2026.01.062","url":null,"abstract":"<div><div>This study evaluated the feasibility, acceptability, and preliminary clinical outcomes of a time-limited, evidence-based telemental health (TMH) intervention delivered within a Graduate Student Mental Health program at a northeastern U.S. university between August 2022 and January 2023. Standard measures of depression and anxiety were collected at pre- and post-treatment and supplemented with electronic health record data for 28 participants who initiated and completed treatment.</div><div>The program consisted of 12 weekly, 45-minute individual psychotherapy sessions delivered via a HIPAA-compliant virtual platform. Feasibility was assessed using enrollment and retention, and acceptability was assessed using engagement indicators, including attendance rates. Thirty-eight students initiated treatment, and 28 completed the program (73.6% retention), with an average attendance of 9.79 of 12 sessions (SD = 2.91). Significant pre-to post-treatment reductions were observed in depression scores, (M = 9.61, SD = 5.24) to M = 5.46, SD = 3.78); t (27) = 5.50, p = &lt; .001), d = 1.04 and anxiety scores (M = 9.93, SD = 4.83) to M = 5.54, SD = 3.81); t (27) = 5.41, p = &lt; .001), d = 1.02.</div><div>These findings provide preliminary evidence that a time-limited TMH model may be a feasible and acceptable intervention for graduate students experiencing psychological distress; however, the small, self-selected, non-randomized sample and the absence of a control group limit conclusions about effectiveness and generalizability. In the context of substantial mental health needs and barriers to care in university settings, the results highlight the potential value of scalable TMH programs for expanding access to treatment among graduate students.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 24-29"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}