Journal of psychiatric research最新文献

{"title":"Temporal dynamics of the wish to live and wish to die signal near-term increases in suicidal thinking in a veteran sample","authors":"Craig J. Bryan,&nbsp;Samantha E. Daruwala,&nbsp;Melanie L. Bozzay","doi":"10.1016/j.jpsychires.2025.06.039","DOIUrl":"10.1016/j.jpsychires.2025.06.039","url":null,"abstract":"<div><div>Preventing suicide is challenging because there are no ways to reliably determine when someone is about transition from a lower to higher risk state. Dynamic interactions between the wish to live (WTL) and die (WTD) may differentiate higher from lower risk suicide states and signal near-term transitions of increasing risk. In this cohort design, clinical trial participants with posttraumatic stress disorder (PTSD) received prompts to complete a brief survey on their phone 4 times per day for 14 consecutive days at pseudorandom times. Participants were asked to rate their WTL, WTD, suicidal desire, and desire for self-preservation using 4 items from the Scale for Suicide Ideation (SSI). Participants were 116 military personnel and veterans diagnosed with PTSD (69.8 % male, 76.7 % White, M age = 47.2 ± 12.1 years). Multilevel dynamical systems modeling revealed that the WTL and WTD changed in coordinated and opposing directions except when suicidal desire was most severe and was about to worsen at the next time point. Under these conditions, WTL and WTD switched to an oscillatory pattern. Temporal patterns in WTL and WTD differ when people report lower versus higher risk suicidal states. Oscillations in WTL and WTD signal near-term worsening of suicidal desire. Multiple qualitatively distinct suicide risk states exist, suggesting suicide risk is categorical, not continuous.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 471-478"},"PeriodicalIF":3.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between blood pressure trajectories during pregnancy and childbirth-related post-traumatic stress disorder symptoms","authors":"Shu Wang ,&nbsp;Linli Zou ,&nbsp;Xiaolu Lai ,&nbsp;Jingfen Chen ,&nbsp;Daniel Krewski ,&nbsp;Shi Wu Wen ,&nbsp;Ri-hua Xie","doi":"10.1016/j.jpsychires.2025.06.037","DOIUrl":"10.1016/j.jpsychires.2025.06.037","url":null,"abstract":"<div><h3>Background</h3><div>Research on the association between blood pressure changes during pregnancy and childbirth-related post-traumatic stress disorder (CB-PTSD) is scarce. This study aimed to explore the impact of blood pressure trajectories during pregnancy on CB-PTSD symptoms.</div></div><div><h3>Methods</h3><div>This cohort study was conducted from October 2022 to August 2023 in Foshan,China. Eligible women were recruited 2–3 days postpartum, with pregnancy blood pressure data retrospectively retrieved from medical records. The Perinatal Post-Traumatic Stress Disorder Questionnaire (PPQ) was used to assess CB-PTSD symptoms 42 days postpartum. A latent class growth model was employed to identify blood pressure trajectories, and logistic regression models were used to estimate the associations between blood pressure trajectories and CB-PTSD symptoms.</div></div><div><h3>Results</h3><div>Among the 709 women included in the study, 67 (9.4 %) exhibited clinically significant CB-PTSD symptoms within 42 days postpartum. Three distinct systolic blood pressure (SBP) and diastolic blood pressure (DBP) trajectories and two pulse pressure (PP) trajectories were identified. Logistic regression analysis showed that the risk of CB-PTSD symptoms was lower in the high-declining PP group (OR = 0.59, 95 %CI = 0.36–0.97) than the low-increasing PP group. After adjusting for confounders, the medium-slow-increasing SBP group (OR = 0.52, 95 %CI = 0.28–0.94) had a lower risk of CB-PTSD symptoms than the low-fast-increasing SBP group. The high-declining PP group (OR = 0.44, 95 %CI = 0.25–0.79) remained associated with a lower risk of CB-PTSD symptoms than the low-increasing PP group after adjustment.</div></div><div><h3>Conclusions</h3><div>Different patterns of blood pressure changes during pregnancy are associated with CB-PTSD symptoms, with wider blood pressure fluctuations potentially exerting a greater impact. Future research should explore the underlying biological and psychological mechanisms of these associations.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 455-463"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep complaints and quality of life and the mediating role of substance use disorders: results from a nationally representative sample","authors":"Bénédicte Ceoara ,&nbsp;Marie Dosquet ,&nbsp;Marina Sánchez-Rico ,&nbsp;Pierre A. Geoffroy ,&nbsp;Carlos Blanco ,&nbsp;Frédéric Limosin ,&nbsp;Nicolas Hoertel","doi":"10.1016/j.jpsychires.2025.06.036","DOIUrl":"10.1016/j.jpsychires.2025.06.036","url":null,"abstract":"<div><h3>Introduction</h3><div>Sleep quality is associated with diminished quality of life. Substance use disorders (SUD) may constitute one leading contributory factor to this relationship.</div></div><div><h3>Methods</h3><div>In a nationally representative sample of US adults aged 18 years or older who were interviewed 3 years apart in the National Epidemiologic Survey on Alcohol and Related Conditions (wave 1, 2001–2002; wave 2, 2004–2005), we used structural equation modeling to examine the shared and specific effects of three sleep complaints at Wave 1 (i.e., trouble falling asleep, early morning awakening, and hypersomnia) on physical and mental health-related quality of life at Wave 2, based on SF-12v2 norm-based physical (PCS) and mental (MCS) scores. We estimated the proportions of these associations mediated by SUD, adjusting for various sociodemographic and clinical characteristics.</div></div><div><h3>Results</h3><div>Sleep complaints were significantly associated with lower MCS and PCS scores among the 34,653 respondents who completed both interviews (β = −0.094, SE = 0.010, p &lt; 0.001; β = −0.042, SE = 0.009, p &lt; 0.001, respectively). These associations were not specific to one type of sleep complaint, but rather were mediated by a single latent factor, representing mechanisms shared by all sleep complaints. A total of 14.42 % and 18.4 % of the effect of that latent factor on MCS and PCS was mediated by a SUD latent factor, representing the shared effects across SUDs.</div></div><div><h3>Conclusion</h3><div>Our findings highlight the importance of adopting dimensional approaches to model the co-occurrence of SUDs and sleep disturbance and suggest the importance of prevention and treatment measures for SUDs among adults with sleep disturbance.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 479-487"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative correlation between level of self-reported antisocial personality disorder symptoms and neural responsiveness to looming threats","authors":"Hui Zhao ,&nbsp;R. James R. Blair ,&nbsp;Huali Zhou ,&nbsp;Changjian Zhai ,&nbsp;Qianglong Wang ,&nbsp;Yaran Zhang ,&nbsp;Xinyu Ding ,&nbsp;Ping Song ,&nbsp;Zhuo Zhang ,&nbsp;Bo Yang","doi":"10.1016/j.jpsychires.2025.06.038","DOIUrl":"10.1016/j.jpsychires.2025.06.038","url":null,"abstract":"<div><h3>Objective</h3><div>Individuals with antisocial personality disorder (ASPD) exhibit an elevated risk for both threat/frustration-based reactive aggression and goal-directed aggression. This heightened risk may be associated with atypical neural responses to environmental threats. The objective of this study was to investigate neural responsiveness to threatening facial stimuli among individuals with varying levels of self-reported ASPD.</div></div><div><h3>Methods</h3><div>Fifty-four male participants were recruited, comprising 27 violent offenders incarcerated in a judicial police hospital and 27 individuals from the community. All participants underwent blood-oxygenation-level-dependent fMRI while engaging in an experiment that involved repeated presentations of angry and neutral facial stimuli, which either loomed towards or receded from them. The level of ASPD was measured using the ASPD subscale from the self-report Personality Disorder Questionnaire.</div></div><div><h3>Results</h3><div>A significant negative correlation was observed between ASPD symptoms and threat responsiveness (looming angry faces versus looming neutral faces) within the left superior temporal gyrus (STG), left inferior temporal gyrus and right ventral tegmental area (VTA).</div></div><div><h3>Conclusion</h3><div>This study provides evidence supporting the association between self-reported levels of ASPD and diminished threat responsiveness. The atypical activation of brain regions underlying the theory of mind (ToM) and facial recognition, particularly in the context of threat perception, is correlated with an increased level of self-reported ASPD symptoms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 464-470"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passive suicide ideation in major depressive disorder: prognostic role and effect of antidepressant treatment","authors":"Paolo Olgiati ,&nbsp;Maria Luca ,&nbsp;Antonina Luca ,&nbsp;Raffaele Ferri ,&nbsp;Alessandro Serretti","doi":"10.1016/j.jpsychires.2025.06.012","DOIUrl":"10.1016/j.jpsychires.2025.06.012","url":null,"abstract":"<div><h3>Background and aims</h3><div>Passive suicidal ideation (PSI)—defined as the desire to die without any intent to act—is a relatively understudied phenomenon. This study investigated its prognostic role in major depressive disorder (MDD) and its evolution during antidepressant treatment.</div></div><div><h3>Methods</h3><div>A total of 482 outpatients (30 % male; mean age = 43.14 ± 12.46 years) from the CO-MED trial were included. Clinical evaluations were conducted at baseline and again after 6 weeks, assessing depressive and hypomanic symptoms, comorbid anxiety, and childhood trauma. PSI was measured using four targeted items from the Concise Health Risk Tracking Self-Report scale (CHRT_PSI; score range 0–16). To distinguish PSI from related depressive symptoms such as hopelessness, a conservative threshold (CHRT_PSI ≥5) was used when analyzing clinical features and treatment response. A broader, more sensitive threshold (CHRT_PSI ≥4) was applied when evaluating PSI's predictive accuracy for suicidal behavior.</div></div><div><h3>Results</h3><div>Compared to patients without PSI, those in the PSI group (n = 283; 59 %) exhibited more severe depressive symptoms, higher rates of comorbid anxiety disorders, and more childhood traumas, including both physical and emotional abuse. While PSI showed modest overall accuracy (37 %–46 %) in predicting suicidal behavior, its sensitivity (66 %–85 %) and negative predictive value (78 %–89 %) were good. PSI was also a significant predictor of response to antidepressants, an effect that remained robust even after adjusting for age, sex, depression severity, and history of childhood maltreatment. Among the 270 PSI patients who completed 6 weeks of treatment, 96 achieved remission from PSI. Insomnia and anhedonia were associated with poorer outcomes, while talkativeness was linked to a higher likelihood of remission.</div></div><div><h3>Conclusion</h3><div>PSI is common in individuals with MDD and is associated with a worse prognosis. Insomnia may act as a barrier to PSI remission during treatment.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 445-454"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated deep intermittent theta-burst stimulation obsessive-compulsive disorder: A double-blind, randomized, controlled study","authors":"Gizem Kavas Akyol ,&nbsp;Bengü Yucens ,&nbsp;Selim Tumkaya","doi":"10.1016/j.jpsychires.2025.06.034","DOIUrl":"10.1016/j.jpsychires.2025.06.034","url":null,"abstract":"<div><h3>Aim</h3><div>The FDA-approved protocol for OCD involves six weeks of 20 Hz deep transcranial magnetic stimulation (dTMS) targeting the medial prefrontal cortex. However, the efficacy of accelerated deep intermittent theta burst stimulation (d-iTBS) targeting the same region has not yet been evaluated in randomized controlled trials. This study addresses this gap by investigating a modified, shorter-duration d-iTBS protocol.</div></div><div><h3>Methods</h3><div>The intervention consisted of five daily sessions over two consecutive weeks, totaling 50 d-iTBS sessions. The primary outcome measures were the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Dimensional Obsessive-Compulsive Scale. Changes in clinical scores were analyzed using repeated measures ANOVA.</div></div><div><h3>Results</h3><div>The reduction in total obsessive-compulsive symptoms (OCS) exhibited a statistically significant difference between the active and placebo groups for the GroupxTime interaction. However, this effect was not observed when examining obsessions and compulsions separately, nor across specific OCS dimensions. Reductions in depressive and anxiety symptoms did not reach statistical significance for the Group × Time interaction. Within the active treatment group, an earlier age at OCD onset was correlated with a greater reduction in total OCS. Pairwise comparisons revealed that changes in total Y-BOCS scores from pre-treatment to the treatment endpoint and from pre-treatment to two-week follow-up were not statistically significant. Nevertheless, the reduction in scores between the treatment endpoint and two-week follow-up showed a trend toward significance (p = 0.051).</div></div><div><h3>Conclusion</h3><div>Accelerated d-iTBS targeting the mPFC appears to be effective in reducing OCD symptoms; however, its therapeutic effects may become more apparent several weeks after the completion of treatment.</div><div>The present trial is registered with ClinicalTrials.gov (NCT06177470).</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 365-372"},"PeriodicalIF":3.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 infection frequency and depressive symptoms in Chinese residents: A moderated mediation model","authors":"Yuan You ,&nbsp;Duo Zhang ,&nbsp;Jin Yu ,&nbsp;Yibo Wu ,&nbsp;Lin Cai","doi":"10.1016/j.jpsychires.2025.06.033","DOIUrl":"10.1016/j.jpsychires.2025.06.033","url":null,"abstract":"<div><h3>Objective</h3><div>Coronavirus disease 2019 (COVID-19) is associated with depressive symptoms, with reinfection posing a risk to mental health. However, few studies have examined the impact of the frequency of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection on perceived stress and depressive symptoms. The present study aimed to examine whether the frequency of SARS-CoV-2 infection is associated with perceived stress and subsequent depressive symptoms and to determine whether socioeconomic status (SES) moderates this mediating effect.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, a total of 30,053 Chinese residents (15,011 males, 49.9 %) aged 19–107 years were recruited between June 20 and August 31, 2023. The participants recalled their frequency of SARS-CoV-2 infection. Perceived stress and depressive symptoms were measured via the Perceived Stress Scale-4 and the Patient Health Questionnaire-9. SES was assessed via a 7-point self-report scale. MANOVA, ANOVA, and conditional indirect effect analysis were performed.</div></div><div><h3>Results</h3><div>Residents with one SARS-CoV-2 infection experienced fewer depressive symptoms than those with no infections. Perceived stress mediated the association between one case of SARS-CoV-2 infection and reduced depressive symptoms, with higher SESs amplifying this association. Conversely, among individuals with multiple infections, the frequency of SARS-CoV-2 infection was associated with increased depressive symptoms.</div></div><div><h3>Conclusion</h3><div>In the postpandemic era, repeated SARS-CoV-2 infections still significantly affect residents' mental health. Attention should be paid to the psychological stress and depressive symptoms of high-risk groups, such as individuals with a history of repeated infections.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 395-402"},"PeriodicalIF":3.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal causal dynamics between perceived burdensomeness and suicidal ideation: Population-based cohort study","authors":"Yiyun Shou ,&nbsp;Monica Gendi ,&nbsp;Rohan Borschmann ,&nbsp;Jennifer Ma ,&nbsp;Mark Larsen ,&nbsp;Jin Han ,&nbsp;Alison L. Calear ,&nbsp;Louise M. Farrer ,&nbsp;Philip J. Batterham","doi":"10.1016/j.jpsychires.2025.06.022","DOIUrl":"10.1016/j.jpsychires.2025.06.022","url":null,"abstract":"<div><div>Better understanding of the determinants of suicidal distress may be critical to improving clinical approaches to suicide prevention. According to the Interpersonal-Psychological Theory of Suicide, perceived burdensomeness (PB) is one of the proximal, causal risk factors for the development of suicidal distress. Considerable cross-sectional data has supported this association, but limited longitudinal data has investigated whether short-term change in PB influences subsequent suicidal ideation (SI). This longitudinal study involved daily assessments of both PB and SI over a 7-day period in 791 Australian adults who reported recent or current SI. Eight different panel models, with and without covariates were fit to examine cross-lagged effects between PB and SI. In the final model, there was weak evidence for a lagged effect from PB on SI the next day (β = 0.175), although the contemporaneous effect of PB on SI was larger and more consistent (β = 0.948). There was little evidence for lagged effects of SI on PB (β = 0.008). Effects varied across age groups and living situations. Inconsistent with the theory, findings suggest limited value of PB in predicting later SI, after accounting for cross-sectional relationships. Greater consideration of other psychosocial and contextual risk factors may be important for theories of suicide risk and for supporting people who are at risk of suicidal behaviour.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 388-394"},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-trauma insomnia and posttraumatic alcohol and cannabis use in the AURORA observational cohort study of trauma survivors","authors":"Nicole A. Short ,&nbsp;Robyn A. Ellis ,&nbsp;Mattea Pezza ,&nbsp;Stacey L. House ,&nbsp;Francesca L. Beaudoin ,&nbsp;Xinming An ,&nbsp;Gari D. Clifford ,&nbsp;Tanja Jovanovic ,&nbsp;Sarah D. Linnstaedt ,&nbsp;Scott L. Rauch ,&nbsp;John P. Haran ,&nbsp;Alan B. Storrow ,&nbsp;Christopher Lewandowski ,&nbsp;Paul I. Musey ,&nbsp;Phyllis L. Hendry ,&nbsp;Sophia Sheikh ,&nbsp;Christopher W. Jones ,&nbsp;Brittany E. Punches ,&nbsp;Lauren A. Hudak ,&nbsp;Jose L. Pascual ,&nbsp;Thomas C. Neylan","doi":"10.1016/j.jpsychires.2025.06.027","DOIUrl":"10.1016/j.jpsychires.2025.06.027","url":null,"abstract":"<div><h3>Background and aims</h3><div>Insomnia symptoms are a potential risk factor for alcohol and cannabis use, particularly in trauma-exposed populations. The initial weeks and months after trauma are a period of risk for problematic substance use, however prior research has not examined whether insomnia symptoms predict alcohol or cannabis use after trauma.</div></div><div><h3>Design</h3><div>Using a large-scale, multi-site, prospective study of trauma survivors presenting to emergency departments (EDs), the current study tested direct and indirect associations between pre-trauma insomnia symptoms, two-week posttraumatic stress disorder (PTSD) symptoms, and eight-week post-trauma heavy alcohol and cannabis use and binge drinking.</div></div><div><h3>Setting</h3><div>Participants were recruited from 23 EDs in the United States and followed up using remote assessments.</div></div><div><h3>Participants/cases</h3><div>Participants were from the AURORA study (n = 2449). A slight majority were women (63.8 %) and were an average of 37 years old. Participants were racially and ethnically diverse (50.5 % Black, 11.2 % Hispanic).</div></div><div><h3>Measurements</h3><div>Participants completed self-report measures during their ED visit, and two- and eight-weeks post-trauma.</div></div><div><h3>Findings</h3><div>Pre-trauma insomnia symptoms significantly predicted eight-week post-trauma heavy alcohol and cannabis use, as well as binge drinking. Associations persisted after covarying for pre-trauma substance use, demographic variables, and trauma severity at the time of emergency care. Further, the association between pre-trauma insomnia symptoms and heavy alcohol and cannabis use at eight-weeks post-trauma was significantly mediated by two-week PTSD symptoms.</div></div><div><h3>Conclusions</h3><div>Insomnia symptoms may be an important malleable risk factor for heavy alcohol and cannabis use and binge drinking after trauma. Further research is needed to explore the effectiveness of insomnia interventions to mitigate post-trauma substance use and to better understand the complex relationships between sleep, trauma, PTSD, and substance use.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 415-423"},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alexithymia and psychopathological dimensions in First-Episode Psychosis: Comparative patterns in natural cannabis versus synthetic cannabinoid users","authors":"Ricci Valerio ,&nbsp;Di Muzio Ilenia ,&nbsp;Mancusi Gianluca ,&nbsp;Ceci Franca ,&nbsp;Ciavarella Maria Celeste ,&nbsp;Di Carlo Francesco ,&nbsp;Pettorruso Mauro ,&nbsp;Martinotti Giovanni ,&nbsp;Maina Giuseppe","doi":"10.1016/j.jpsychires.2025.06.025","DOIUrl":"10.1016/j.jpsychires.2025.06.025","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to investigate the differences in psychotic symptomatology, dissociative symptoms, alexithymia, and aberrant salience among three groups: non-cannabis users (NU), natural cannabis users (NC), and synthetic cannabinoid users (SCs). The study also explored the patterns of alexithymia and its associations with other psychopathological dimensions in these populations.</div></div><div><h3>Methods</h3><div>A total of 108 participants experiencing First Episode Psychosis (FEP) were recruited during psychiatric crisis presentations to emergency rooms in Italy and categorized into three groups (NU, NC, SCs; n = 36 each). Participants were initially assessed 48–72 h after inpatient admission following clinical stabilization. Psychopathological assessments were conducted using the Positive and Negative Syndrome Scale (PANSS), Dissociative Experiences Scale (DES-II), Aberrant Salience Inventory (ASI), and Toronto Alexithymia Scale (TAS-20). Evaluations occurred at baseline (T0), three months (T1), and six months (T2) post-admission. Statistical analyses included ANOVA and repeated-measures ANOVA comparisons across time points.</div></div><div><h3>Results</h3><div>SC users exhibited significantly higher positive psychotic symptoms, persistent aberrant salience, and limited recovery of alexithymia compared to NC users and non-users. Dissociative symptoms were more prominent in both NC and SCs users, with SCs users showing minimal improvement over time. Negative symptoms were higher in non-users but showed progressive reduction across all groups. Significant correlations were observed between alexithymia and specific aberrant salience subscales, particularly Feelings of Increased Significance and Sense Sharpening.</div></div><div><h3>Conclusions</h3><div>Synthetic cannabinoids are associated with more severe and persistent psychotic symptoms and emotional dysregulation compared to natural cannabis. Alexithymia and dissociation showed distinct patterns across user groups, with different trajectories of change over the six-month observation period. These findings underscore the need for targeted interventions addressing emotional regulation and salience processing in cannabis-related psychosis.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 325-334"},"PeriodicalIF":3.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}