Journal of psychiatric research最新文献

{"title":"Corrigendum to “The gray matter microstructure and psychological resilience in patients with depression: A preliminary study using DSI/NODDI Imaging” [Journal of Psychiatric Research 189 (2025) 335–342]","authors":"Liaoming Gao , Zhimin Chen , Ziqi Wu , Junyan Wen , Zhujia Li , Ying Guo , Jingwen Luo , Liya Gong , Zhiting Chen , Lin Wang , Linlin Jing , Honglei Yin , Ge Wen","doi":"10.1016/j.jpsychires.2025.09.071","DOIUrl":"10.1016/j.jpsychires.2025.09.071","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Page 568"},"PeriodicalIF":3.2,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in non-fatal suicidal self-directed violence prevalence and methods among U.S. Veterans.","authors":"Claire A Hoffmire, Julie A Kittel, Ryan Holliday, Theresa T Morano, Yuki Imai, Lindsey L Monteith","doi":"10.1016/j.jpsychires.2025.10.013","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.10.013","url":null,"abstract":"<p><p>While men Veterans have higher rates of suicide than women Veterans, women Veterans appear to experience higher rates of lifetime suicide attempt(s) (SA). Understanding gender differences in suicidal ideation (SI) and non-fatal suicidal self-directed violence (NF-SSDV) among Veterans can facilitate Veteran suicide prevention that is responsive to the needs of both women and men Veterans. The present study analyzed data from the Assessing Social and Community Environments with National Data for Veteran Suicide Prevention study to examine gender differences in the prevalence of different types of SI and NF-SSDV, methods considered and used, and prevalence across demographic subgroups. Analyses were weighted to provide population-based estimates. Compared to men, women had significantly higher prevalence of SI, interrupted attempt, and SA; for example, 34.07 % (95 %CI = 31.86-36.36) of women reported post-military SI, compared to 24.86 % (95 %CI = 23.81-25.95) of men. Post-military SI and SA prevalence remained higher among women relative to men in most subgroups; however, notable differences in this pattern were observed by age, race, time since separation, and use of Veterans Health Administration services. Among Veterans with past-year SI, men were more likely to consider gunshot and jumping than women as suicide methods. Among Veterans with lifetime SA, women were more likely to report using medication overdose, while men were more likely to report gunshot and illegal drug overdose. These findings confirm and expand upon prior research demonstrating women Veterans as at increased risk for experiencing SI and NF-SSDV and emphasize the need for suicide prevention strategies that address methods and drivers of SI and NF-SSDV among women and men Veterans.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"653-663"},"PeriodicalIF":3.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DRD1 gene is associated with craving changes during withdrawal among patients with alcohol use disorder","authors":"Ze-Yu Lin ,&nbsp;Yu-Li Liu ,&nbsp;Pin-Wei Lee ,&nbsp;Tung-Hsia Liu ,&nbsp;Ren-Hua Chung ,&nbsp;Hsiang-Wei Kuo ,&nbsp;Hu-Ming Chang ,&nbsp;Jia-Ling Shih ,&nbsp;Ming-Chyi Huang","doi":"10.1016/j.jpsychires.2025.10.014","DOIUrl":"10.1016/j.jpsychires.2025.10.014","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol use disorder (AUD) is a chronic relapsing condition in which craving is closely linked to relapse. Previous research has shown that the single nucleotide polymorphisms (SNPs) of the dopamine receptor D1 (<em>DRD1</em>) gene are not associated with craving severity when assessing cross-sectionally. Since craving severity may change after withdrawal, this study tracked craving dynamics over a two-week withdrawal period and examined the relationships with <em>DRD1</em> SNPs.</div></div><div><h3>Methods</h3><div>We recruited 221 Taiwanese Han patients with severe AUD diagnosed based on DSM-5-TR and undergoing withdrawal treatment and 117 healthy controls. Alcohol craving was assessed at baseline and after one and two weeks of withdrawal using the Obsessive-Compulsive Drinking Scale (OCDS). <em>DRD1</em> SNPs were imputed from the genome-wide database, including rs12518222, rs4867798, rs686, rs4532, rs5326, rs265981. Single SNP and haplotype-based analyses were used to evaluate the associations between <em>DRD1</em> SNPs and craving.</div></div><div><h3>Results</h3><div><em>DRD1</em> SNPs of rs12518222 (3′-UTR) and rs5326 (5′-UTR) of genotype and allele types were significantly associated with AUD (P = 0.008 and &lt; 0.001, respectively). Carriers of the minor alleles at 3′-UTR of rs12518222 (T), rs4867798 (C), and rs5326 (A) and major alleles at 5′-UTR of rs686 (A), rs4532 (T), and rs265981 (G) were associated with higher post -withdrawal craving compared to the counterparts. The haplotype TCATTG, comprising the corresponding allele associated with higher craving was linked to more severe craving severity.</div></div><div><h3>Conclusion</h3><div><em>DRD1</em> gene influences post-withdrawal changes in cravings in AUD patients. These findings may guide personalized treatment strategies aimed at improving craving management and reducing relapse risk.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 590-596"},"PeriodicalIF":3.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of T1-Weighted MRI in bipolar disorder: A systematic review and meta-analysis","authors":"Lina M. González-Ojeda ,&nbsp;Alejandra Torres-Parga ,&nbsp;Lina M. Villegas-Trujillo ,&nbsp;Juan F. Cardona","doi":"10.1016/j.jpsychires.2025.10.004","DOIUrl":"10.1016/j.jpsychires.2025.10.004","url":null,"abstract":"<div><h3>Objective</h3><div>Bipolar affective disorder (BPAD) is a clinically defined psychiatric condition characterized by heterogeneous symptom patterns and a reliance on subjective assessments. Structural neuroimaging, particularly gray matter volume (GMV) from T1-weighted MRI, has been investigated as a complementary diagnostic tool. However, its clinical applicability remains uncertain. This systematic review and meta-analysis evaluated the diagnostic performance of GMV in BPAD by synthesizing sensitivity, specificity, and classification accuracy, while accounting for demographic and methodological variability.</div></div><div><h3>Methods</h3><div>A comprehensive PRISMA-based literature search identified <strong>15 structural MRI studies including 1645 participants</strong>. Of these, <strong>eight studies (n = 780)</strong> met inclusion criteria for quantitative synthesis based on reporting diagnostic metrics such as sensitivity and specificity. Pooled estimates were calculated, and subgroup and meta-regression analyses were conducted to examine the influence of age, sex, and control group characteristics.</div></div><div><h3>Results</h3><div>GMV demonstrated moderate diagnostic accuracy, with a pooled sensitivity of 0.69 and a specificity of 0.77. Classification performance was higher in older adults than in younger cohorts. Sex-related GMV differences were observed in healthy controls but were attenuated in BPAD. Meta-regression identified control group size as a significant moderator of heterogeneity, with additional variability likely due to medication exposure and illness subtype.</div></div><div><h3>Conclusions</h3><div>GMV may provide incremental diagnostic value when integrated with clinical evaluation, particularly in older adults. Nonetheless, methodological heterogeneity and the modest accuracy observed indicate that GMV alone is insufficient as a biomarker. By incorporating the most recent evidence, these findings reinforce the need for multimodal diagnostic approaches that combine structural MRI with genetic, functional, and clinical data.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 604-616"},"PeriodicalIF":3.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple network alteration predicts dissociative symptoms following activation of the attachment system: Evidence from an EEG connectivity study.","authors":"Giuseppe A Carbone, Benedetto Farina, Aurelia Lo Presti, Claudio Imperatori, Elena De Rossi, Mauro Adenzato, Rita B Ardito","doi":"10.1016/j.jpsychires.2025.10.016","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.10.016","url":null,"abstract":"<p><p>Dissociation is a psychological response to stress that impairs mental integration, identity, and consciousness and manifests itself in the form of detachment and compartmentalization. Such symptoms are common in psychiatric disorders and reflect altered brain connectivity. In this study, EEG connectivity at rest, before and after activation of the attachment system, was analysed in relation to the two forms of dissociation. The study included 98 participants (55 women, mean age 22.7 ± 6.9 years) who completed clinical/socio-demographic questionnaires and the Reading the Mind in the Eyes test for mentalization. Two resting-state EEG sessions (before and after the Adult Attachment Projective) were recorded. Connectivity between nine hubs of the Default Mode Network (DMN), Central Executive Network (CEN) and Salience Network (SN) was analysed using the exact Low-Resolution Electromagnetic Tomography software (eLORETA). Statistical analyses included four SnPM regressions for EEG-DCI correlations and a multiple WLS regression to predict compartmentalization, controlling for confounding factors. The eLORETA analysis showed a significant correlation between compartmentalization (DCI-C) and increased alpha connectivity between the dorsal Anterior Cingulate Cortex and the right dorsolateral prefrontal cortex after attachment-related stimuli. Neither the baseline nor the detachment subdimension showed a significant correlation. The regression analysis showed that SN-CEN connectivity, age, male gender and tobacco use significantly predict compartmentalization. These results might reflect dysfunctional cognitive control over emotional processing that contributes to the disconnection of conscious experience typical of compartmentalization. The pattern is particularly prominent following activation of the attachment system, suggesting the clinical utility of integrated therapeutic models targeting alpha connectivity between SN and CEN to reduce dissociative symptoms.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"664-670"},"PeriodicalIF":3.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and clinical correlates of persistent anhedonia in the remitted patients with bipolar depression.","authors":"Peiyun Zhang, Wanyan Zhou, Fang Guo, Yao Zhang, Xiaoxiao Wang, Qianqian Qin, Peijuan Wang, Qi Yan, Qinyu Lv, Zhenghui Yi","doi":"10.1016/j.jpsychires.2025.10.015","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.10.015","url":null,"abstract":"<p><strong>Background: </strong>Anhedonia is increasingly recognized as a persistent symptom over the course of disease. Findings on the symptoms of anhedonia in remitted bipolar disorder are inconsistent, and little is known about the characteristics and relative factors in these patients. This study was conducted to explore the characteristics and clinical correlates of anhedonia in remitted patients with bipolar depression.</p><p><strong>Methods: </strong>Sixty bipolar patients in partial remission following a recent depressive episode and sixty healthy controls were recruited from September 2023 to December 2023. Anhedonia was evaluated using the Snaith-Hamilton Pleasure Scale (SHAPS), the Temporal Experience of Pleasure Scale (TEPS), the Revised Social Anhedonia Scale-Chinese Version (RSAS-C), and the Revised Physical Anhedonia Scale-Chinese Version (RPAS-C). Depressive, anxious, manic symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17), the 14-item Hamilton Anxiety Scale (HAMA-14), the Young Mania Rating Scale (YMRS), and cognitive function using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). T-tests and MANCOVA were conducted to compare clinical scale scores between remitted bipolar patients and healthy controls. Pearson and partial correlation analyses (adjusted for antidepressant dose and mean body mass index, BMI) were used to examine correlates of anhedonia in remitted bipolar patients.</p><p><strong>Results: </strong>The scores on RSAS-C and RPAS-C were significantly higher for remitted bipolar patients than for healthy controls (P < 0.05), whereas no significant differences were found in scores on the TEPS and SHAPS between the two groups. Pearson correlations showed social and physical anhedonia negatively correlated with total RBANS and several subdomains, while consummatory pleasure positively correlated with delayed memory subscale. After adjusting for antidepressant dose and BMI, partial correlations confirmed that social anhedonia was negatively associated with total RBANS and immediate memory, visuospatial/constructional, language, and attention subscales; physical anhedonia was negatively associated with total RBANS, immediate memory, and attention; and consummatory pleasure was positively correlated with attention subscale. No significant associations were found between HAMD-17 and anhedonia scales.</p><p><strong>Conclusion: </strong>Our findings indicate persistent social and physical anhedonia in bipolar patients in partial remission following a recent depressive episode. Moreover, cognitive function is significantly correlated with the severity of social and physical anhedonia, independent of antidepressant dosage.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"671-677"},"PeriodicalIF":3.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic markers of psychoactive substance addiction in peripheral blood","authors":"Anna Yakovchik ,&nbsp;Ekaterina Spektor ,&nbsp;Aleksandra Mamchur ,&nbsp;Mikhail Ivanov ,&nbsp;Еlena Zelenova ,&nbsp;Daria Kashtanova ,&nbsp;Lorena Matkava ,&nbsp;Mikhail Terekhov ,&nbsp;Aleksandra Nekrasova ,&nbsp;Aleksander Nekrasov ,&nbsp;Daria Tarasova ,&nbsp;Ekaterina Bolashova ,&nbsp;Sergey Mitrofanov ,&nbsp;Konstantin Pavlov ,&nbsp;Olga Pavlova ,&nbsp;Kira Nebogina ,&nbsp;Sakina Bairamova ,&nbsp;Aleksander Kozlov ,&nbsp;Svetlana Shport ,&nbsp;Vladimir Yudin ,&nbsp;Sergey Yudin","doi":"10.1016/j.jpsychires.2025.09.061","DOIUrl":"10.1016/j.jpsychires.2025.09.061","url":null,"abstract":"<div><div>The regular use of psychoactive substances, resulting in substance use disorders, represents a significant public health concern globally. Due to genetic variability and the substantial impact of environmental factors, identifying specific genes associated with predisposition to addictive behaviors presents a significant challenge. Regular exposure to psychoactive substances is known to change gene expression levels in the brain regions for reward and motivation. These changes affect the dopaminergic, glutamatergic, and cannabinoid systems of the brain. The existing data on cellular gene expression in the central nervous system has been predominantly derived from postmortem brain samples or animal models, which limits their clinical applicability. Therefore, analyzing gene expression levels in peripheral blood may provide considerable advantages for clinical practice. In this study, we conducted a differential gene expression analysis followed by a pathway analysis in individuals with long-term substance use disorders, such as opiates, psychostimulants, and cannabinoids. Our results revealed a significant number of genes exhibiting differential expression in peripheral blood. The pathway analysis suggested that the metabolic changes associated with regular substance use primarily impact energy catabolism, toxin metabolism, anabolic processes, and cell signaling pathways. The examination of peripheral blood transcriptome profiles provided valuable insights into the overall health status of individuals with substance use disorders related to various classes of psychoactive substances. Transcriptome analysis has the potential to significantly enhance the diagnosis of substance use disorders.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 569-577"},"PeriodicalIF":3.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older adults’ subjective age and post-traumatic symptoms during Wartime: The role of future time perspective","authors":"Yoav S. Bergman ,&nbsp;Gali H. Weissberger ,&nbsp;Rotem Saar","doi":"10.1016/j.jpsychires.2025.10.006","DOIUrl":"10.1016/j.jpsychires.2025.10.006","url":null,"abstract":"<div><div>The traumatic events of October 7, 2023, and the ensuing war between Israel and Hamas has resulted in unprecedented challenges to the Israeli society, notwithstanding increased post-traumatic symptomatology (PTS) in younger and older Israelis. Recent findings have highlighted the importance of positive subjective aging perceptions for various aspects of older adults' physical and psychological health. As trauma may interfere with one's ability to think positively and plan for the future, the current study examined the interactive effect of subjective age and future time perspective on Israeli older adults' PTS during the war. Data were collected during January–March 2024, from 533 Israeli older adults (<em>M</em>_age = 73.88, <em>SD</em> = 7.34), who filled out scales assessing sociodemographic information, war-related exposure, subjective age, future time perspective, and PTS. Results demonstrated that a young subjective age was associated with reduced PTS. However, this link was not significant among older adults reporting a wide future time perspective. The discussion highlights the importance of combining both subjective aging and subjective time perceptions when examining PTS among older adults during an ongoing national crisis.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 522-526"},"PeriodicalIF":3.2,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive impairment and functional outcome in cognitive-behavioral social skills training for schizophrenia","authors":"Amber V. Keller ,&nbsp;Kristen Dwyer ,&nbsp;Jason Holden ,&nbsp;Delaney Pickell ,&nbsp;Elizabeth W. Twamley ,&nbsp;Eric Granholm","doi":"10.1016/j.jpsychires.2025.10.002","DOIUrl":"10.1016/j.jpsychires.2025.10.002","url":null,"abstract":"<div><h3>Background</h3><div>Neurocognitive impairment is associated with low functional outcome in schizophrenia. Mixed findings exist regarding the impact of neurocognitive impairment on functional improvement following psychosocial treatments. Cognitive-Behavioral Social Skills Training (CBSST) is an intervention aimed at improving functioning. The current study examined whether baseline neurocognitive impairment moderated functional outcome in CBSST relative to a goal-focused supportive contact condition (GFSC).</div></div><div><h3>Study design</h3><div>This is a secondary analysis of two single-blind, randomized controlled trials conducted in individuals with schizophrenia or schizoaffective disorder (Trial 1: N = 64 (older adults <u>M</u> age = 55.0); Trial 2: N = 149 (<u>M</u> age = 41.4)). Participants received 36 weekly 2-h group sessions of either CBSST or GFSC. CBSST combined cognitive behavioral therapy with social skills training and problem solving to improve functioning. GFSC focused on setting and achieving functioning goals, with minimal therapist guidance. Regression models examined whether multiple domains of baseline neuropsychological impairment moderated functional outcome at 9- or 12- month follow-up in CBSST relative to GFSC.</div></div><div><h3>Study results</h3><div>Executive function impairment, but not any other neuropsychological domain, was a significant moderator of treatment outcome. Lower executive functioning was associated with <em>better</em> functioning at follow-up in CBSST than in GFSC, whereas higher executive functioning was associated with similar functional outcome in CBSST and GFSC.</div></div><div><h3>Conclusions</h3><div>Individuals with cognitive impairment can benefit from CBSST and may even benefit more than individuals with intact cognition. The thought challenging, cognitive flexibility and problem-solving skills trained in CBSST may be compensatory for individuals with schizophrenia with executive function deficits.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 561-567"},"PeriodicalIF":3.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritizing brain Metabolism: Evidence from brain temperatures of severe underweight individuals","authors":"Arne Doose ,&nbsp;Friederike I. Tam ,&nbsp;Dominic Arold ,&nbsp;Carolin Kutzke ,&nbsp;Tyler Starr ,&nbsp;Veit Roessner ,&nbsp;Jennifer Linn ,&nbsp;Alexander P. Lin ,&nbsp;Stefan Ehrlich","doi":"10.1016/j.jpsychires.2025.09.055","DOIUrl":"10.1016/j.jpsychires.2025.09.055","url":null,"abstract":"<div><h3>Objective</h3><div>Severe and prolonged underweight can lead to a hypometabolic state and hormonal adaptations that reduce body temperature often found in Anorexia Nervosa (AN). However, the effect of these changes on brain temperature remains unclear. We aimed to investigate whether brain temperature remains stable despite lower body temperature in a severe underweight state, testing the hypothesis that the brain prioritizes its own energy needs during periods of food deprivation.</div></div><div><h3>Method</h3><div>We collected magnetic resonance spectroscopy (MRS) measurements from 30 female patients with acute Anorexia Nervosa (acAN) in a severe underweight state and 30 age-matched healthy female control participants (HC). MRS allows for a non-invasive assessment of brain temperature by calculating the difference between the temperature-independent peak of N-acetylaspartate (NAA) and the temperature-dependent peak of water (H20) in each voxel (Δ_H20-NAA).</div></div><div><h3>Results</h3><div>Our results showed no group differences in (Δ_H20-NAA) between acAN and HC. This is supported by Bayesian hypothesis testing, providing strong evidence for the absence of lower brain temperatures in severely underweight states.</div></div><div><h3>Conclusion</h3><div>Our results are an indication that in a state of low energy availability, brain metabolism is prioritized.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 542-546"},"PeriodicalIF":3.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}