Journal of psychiatric research最新文献

{"title":"Associations between momentary mental states and concurrent social functioning after remission from first episode psychosis: A HAMLETT ecological momentary assessment study.","authors":"Matej Djordjevic, Hannah E Jongsma, Claudia J P Simons, Priscilla P Oomen, Lieuwe de Haan, Nynke Boonstra, Martijn Kikkert, Sanne Koops, Chris N W Geraets, Marieke J H Begemann, Machteld Marcelis, Wim Veling","doi":"10.1016/j.jpsychires.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.12.002","url":null,"abstract":"<p><strong>Background: </strong>Symptom severity and social functioning are important outcomes after first episode psychosis (FEP), yet current evidence about associations between them is inconsistent and lacks (subclinical) momentary insights.</p><p><strong>Methods: </strong>The current Ecological Momentary Assessment (EMA) study was conducted in 58 people in remission from FEP, as part of the HAMLETT (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment) trial. At baseline, participants were prompted to report momentary mental states and social context 10x/day for eight consecutive days, including psychotic experiences (PEs), motivation/drive and negative affect, that may indicate proxies of (subclinical) psychotic, negative and general affective symptoms, respectively. We employed multilevel mixed-effects regressions to investigate associations between self-reported mental states and concurrent activity or social company and subjective appraisal thereof. We also conducted retrospective clinical assessments of symptoms (PANSS) and social functioning (WHODAS 2.0) and investigated their cross-sectional associations using multivariable linear regression.</p><p><strong>Results: </strong>Analyses of 3101 EMA-questionnaires showed that lower motivation/drive was associated with more passive activity and less company (OR = 0.96 [95%CI: 0.96; 0.97], OR = 0.95 [95%CI: 0.93; 0.96], N.B. ORs per 1-point symptom-score change). PEs and negative affect were associated with more proactive activity (OR = 1.02 [95%CI: 1.00; 1.03], OR = 1.02 [95%CI: 1.01; 1.03]). All three mental state domains were associated with lower activity appraisal overall, though activity-specific associations differed. PEs and negative affect were associated with lower company appraisal (B = -0.25 [95%CI: -0.36; -0.14], B = -0.15 [95%CI: -0.23; -0.06]). When assessed retrospectively, only PANSS general psychopathology was associated with poorer social functioning (B = 2.52 [95%CI: 1.69; 3.34]).</p><p><strong>Conclusion: </strong>Self-reported PEs, momentary motivation/drive and general affective symptoms are associated with daily-life functioning after remission from FEP. Retrospective observer-rated and momentary self-report assessment methods do not measure the same aspects or intensity of psychopathology.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"560-569"},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis use and binge eating among young adults: The role of depressive symptoms.","authors":"Roni Elran-Barak, Sharon Sznitman, Marla E Eisenberg, Lydia Zhang, Melanie M Wall, Dianne Neumark-Sztainer","doi":"10.1016/j.jpsychires.2024.12.015","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.12.015","url":null,"abstract":"<p><strong>Objective: </strong>Understanding the association between cannabis use and binge eating is of interest amidst growing global cannabis legalization. While preliminary research suggests a link between cannabis use and binge eating, population-based data among young adults, both female and male, are lacking. Given that depressive symptoms can act as an important precipitant of both cannabis use and binge eating, exploring the role of depressive symptoms is essential.</p><p><strong>Methods: </strong>Emerging adults (n = 1568; 53% female, 22.2 ± 2.0 years old) completed surveys in 2017-2018 as part of EAT 2010-2018 (Eating and Activity over Time). Gender stratified models of past-year cannabis use by binge eating were adjusted for sociodemographic characteristics, depressive symptoms, and body mass index (BMI).</p><p><strong>Results: </strong>Using cannabis in the last year was reported by 33% (n = 233) of males and 27% (n = 218) of females. Rates of binge eating differed (p < 0.001) between female cannabis users (24%, n = 51), and non-users (13%, n = 74). These differences were not found among males (5.5% vs 8.2%, p = 0.2). Adjusted regression model suggested that cannabis use is linked with binge eating among females but not among males (p < 0.001), and that this link remains significant after controlling for depressive symptoms.</p><p><strong>Conclusion: </strong>The observed association between cannabis use and binge eating in female young adults, independent of depressive symptoms, suggests a direct connection potentially influenced by cannabis-induced changes in appetite and cravings. These findings inform policy and practice by emphasizing the need for gender-specific interventions, such as psychoeducation programs, to address the effects of cannabis on appetite and its link to binge eating.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"553-559"},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADHD and alcohol: Emotional regulation efforts pay off in quality of life points.","authors":"Amandine Luquiens, Thibault Mura, Alexandra Dereux, Patrice Louville, Hélène Donnadieu, Marie Bronnec, Amine Benyamina, Pascal Perney, Arnaud Carré","doi":"10.1016/j.jpsychires.2024.12.012","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.12.012","url":null,"abstract":"<p><p>The emotion dysregulation and impulsivity are highly associated with alcohol use disorder (AUD). This study explored the role of impulsivity and emotion dysregulation and the interaction with adult probable ADHD on alcohol-related quality of life (QoL). In this observational trial, we analyzed data from the randomized TRAIN study, which compared efficacy of two cognitive training programs in patients AUD recently detoxified at 5 centers in France from February 2019 to February 2023, and who completed child and adult ADHD screening data (WURS + ARSR, n = 206 of 226). We collected baseline data on AUD severity, age, sex, quality of life (AQoLS), cognitive impairment (MoCA), impulsive behavior (UPPS-P) and emotion dysregulation (ERQ expressive suppression subscore, DERS-impulse). Patients with probable and without ADHD were compared. We performed multiple linear regression explaining the total AQoLS score (dependent variable) by impulsivity (UPPS-P score), emotion regulation (DERS-impulse), and expressive suppression (ERQ expressive suppression subscore), and their interaction with ADHD, adjusted on MoCA, sex, age. Forty (19%) patients were above the screening threshold for ADHD. The impact of alcohol on QoL was greater in them than in those without ADHD (57.3 (21.9) vs. 46.4 (19.6), p = 0.002). High impulsivity and emotion dysregulation dimensions were both significantly associated with poorer QoL. ADHD interacted significantly with expressive suppression to worsen the impact of alcohol on QoL (p = 0.04). The dysfunctional attempts to compensate for the strong dysregulation of emotions in ADHD lowers QoL in AUD.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"463-469"},"PeriodicalIF":3.7,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The therapeutic effects of theta burst stimulation on negative symptoms in chronic schizophrenia using functional near-infrared spectroscopy.","authors":"Chunying Gao, Guangjian Li, Zhou Wang, Qingwei Jiang, Rongrong He, Jingjing Sun, Yangyang You, Yingzhi Zhu, Jing Zhao, Xiangrong Zhang, Chao Zhou","doi":"10.1016/j.jpsychires.2024.12.010","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.12.010","url":null,"abstract":"<p><strong>Background: </strong>To explore the efficacy of theta burst stimulation (TBS) on the negative symptoms in patients with chronic schizophrenia, and to investigate the alterations of local brain activity using functional near-infrared spectroscopy (fNIRS).</p><p><strong>Methods: </strong>100 patients with chronic schizophrenia were enrolled and divided into the real group (50 subjects) and sham group (50 subjects). The real group was given real stimulation of TBS for 4 weeks, and the sham group was sham-stimulated with the same site. The Positive and Negative Symptom Scale (PANSS) and the Scale for Assessment of Negative Symptoms (SANS) were used to assess the clinical symptoms. fNIRS was used to detect the amplitude of low frequency fluctuation (ALFF) of cortical hemoglobin before and after TBS. Repeated analysis of variance (ANOVA) was used to compare the changes in clinical features between the two groups. Correlation analysis was used to explore the associations between altered ALFF and clinical features.</p><p><strong>Results: </strong>Repeated ANOVA revealed that the interaction effect of group∗time showed significant influence on the scores of PANSS-total, PANSS-negative, and SANS in the two groups of patients. Test of within-subjects effects showed that significant reductions in scores of PANSS-total, PANSS-negative, and SANS were found between the real group and sham group after TBS, as well as in the real group before and after TBS. fNIRS revealed that the normalized ALFF (zALFF) of deoxyhemoglobin in the left dorsolateral prefrontal cortex was decreased in the real group after TBS. Furthermore, the zALFF of oxyhemoglobin was increased in the right and left frontal pole regions, and decreased in the right superior temporal gyrus in the real group compared to the sham group after TBS. Correlation analysis showed that the alterations of zALFF in frontal regions after treatment were associated with the improvement of negative symptoms in chronic schizophrenia patients.</p><p><strong>Conclusions: </strong>Short-term TBS is effective in the improvement of negative symptoms of chronic schizophrenia. fNIRS could reveal the changes in brain activity after TBS treatment, providing an effective technique for exploring the efficacy of TBS in schizophrenia.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"484-491"},"PeriodicalIF":3.7,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autistic traits are associated with the presence of post-traumatic stress symptoms and suicidality among subjects with autism spectrum conditions and Anorexia nervosa.","authors":"Liliana Dell'Osso, Ivan Mirko Cremone, Ilaria Chiarantini, Benedetta Nardi, Cristiana Pronestì, Giulia Amatori, Enrico Massimetti, Maria Salvina Signorelli, Matteo Rocchetti, Giovanni Castellini, Eugenio Aguglia, Pierluigi Politi, Valdo Ricca, Stefano Pini, Barbara Carpita","doi":"10.1016/j.jpsychires.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.12.006","url":null,"abstract":"<p><strong>Introduction: </strong>Recently, growing attention has been paid to the presence of undetected Autism Spectrum Disorder (ASD) and subthreshold autistic traits (ATs) among females, and on their gender specific manifestation. In particular, the recent literature focused on the overlap between autism spectrum and eating disorders, which share with ASD not only features such as of cognitive inflexibility but also a link with trauma- and stress-related disorders. In this framework, we aimed to assess the interaction between ATs, stress- or trauma-related symptoms, and the risk of suicidality in subjects with different mental conditions.</p><p><strong>Methods: </strong>184 subjects were divided in three diagnostic groups: Broad autism phenotype (BAP), Anorexia Nervosa (AN) and Healthy Controls (HCs) and assessed with the Adult Autism Subthreshold Spectrum (AdAS Spectrum) questionnaire, the Trauma and Loss Spectrum - Self Report (TALS - SR) questionnaire and the Mood Spectrum - Self Report (MOODS - SR) questionnaire.</p><p><strong>Results: </strong>AN subjects reported notable ATs reinforcing the hypothesis that AN might represent an atypical ASD manifestation more common in women. Furthermore, both AN and BAP subjects showed a considerable presence of trauma/stress associated symptoms. The dimension of trauma/stress related symptoms also appeared to be associated with ATs, and to significantly mediate the relationship between ATs and suicidality risk. Lastly, AN were found to have a stronger correlation with the presence of post-traumatic stress symptoms.</p><p><strong>Conclusions: </strong>the results support the presence of a link between ATs and AN. Moreover, AN seems to be more strongly associated with post-traumatic stress symptoms than BAP. ATs and trauma/stress related symptoms may interact in shaping suicidality risk in these patients.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"492-502"},"PeriodicalIF":3.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, correlates and comorbidity of irritability in adults with major depressive episode in the U.S. population (2012-2013).","authors":"Matthieu Rizk, Sarah Tebeka, Caroline Dubertret, Yann Le Strat","doi":"10.1016/j.jpsychires.2024.11.074","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.074","url":null,"abstract":"<p><strong>Background: </strong>Irritability has been documented in major depressive episodes (MDE) in children and adolescents. However, the prevalence of irritability in MDE and its clinical correlates remain unknown in adults.</p><p><strong>Method: </strong>We showed associations between the prevalence of irritability and its sociodemographic characteristics in a representative U.S. sample, along with the associations between irritability and other psychiatric disorders and its relationship with health-related quality of life. This cross-sectional study utilized a large national sample (n = 36,309) from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Face-to-face interviews were conducted to collect sociodemographic characteristics, structured diagnoses, and self-reported irritability.</p><p><strong>Results: </strong>The irritable MDE group (n = 4988) was compared to the non-irritable MDE group (n = 3065). The lifetime prevalence of irritability in MDE was estimated at 61.3%. Participants with irritable MDE were significantly more likely to report a lifetime history of psychiatric disorders (aOR = 1.96) than those with non-irritable MDE. Irritable MDE was also positively associated with severe MDE (aOR = 2.12). Participants with irritable MDE were more likely to report a lifetime history of suicide attempts (aOR = 1.15), substance use disorders (aOR = 1.54), mood disorders (aOR = 1.93), and anxiety disorders (aOR = 1.67). Participants with irritable MDE had lower levels of health-related quality of life than those with non-irritable MDE.</p><p><strong>Conclusions: </strong>The majority of adults with MDE exhibits irritability. Irritability is associated with severe characteristics and comorbidities, leading to a higher burden of depression.</p><p><strong>Significance: </strong>This study demonstrates a strong association between irritable MDE and psychiatric comorbidities, as well as a substantial burden of depression and related conditions. As a cross-sectional study using a representative sample of the U.S. population with highly reliable psychiatric diagnoses, our results are generalizable. Practitioners managing MDE should identify and treat these comorbidities.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"517-522"},"PeriodicalIF":3.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and psychosocial factors associated with suicidal ideation in adolescents with depression: An ecological model of health behavior.","authors":"Hua Xu, Zhao-Hong Chen, Jin-Jie Ji, Hua-Ying Qian, Juan She, Chun-Ting Hou, Yan-Hong Zhang","doi":"10.1016/j.jpsychires.2024.12.014","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.12.014","url":null,"abstract":"<p><strong>Background: </strong>Although many studies have examined the relationship between suicidal ideation and psychosocial factors in adolescents, there are differences between the results.</p><p><strong>Methods: </strong>Adopting the ecological model of health behavior as a theoretical framework, this study assessed individual, interpersonal and organizational factors associated with the prevalence of suicidal ideation and preventive behaviors in 305 Chinese adolescents hospitalized with depression. Clinical and demographic data were collected by a self-administered questionnaire. The Hamilton Depression Scale (HAMD) and suicidal ideation were assessed by interview.</p><p><strong>Results: </strong>The prevalence of suicidal ideation among the sample was 75.7% (231/305). Logistic regression showed that the increase of suicide ideation was associated with woman (OR = 2.237, 95%CI = 1.074-4.659), degree of depression(moderate depression: OR = 10.198, 95%CI = 3.819-27.237; major depression: OR = 21.677, 95%CI = 7.006-67.076), and high emotion-oriented coping(OR = 1.985, 95%CI = 0.977-4.034). However, high psychological resilience had lower rates of suicidal ideation (OR = 0.384, 95%CI = 0.158-0.933).</p><p><strong>Conclusion: </strong>These findings highlight the need to pay sufficient attention to individuals with these risk factors for suicidal ideation in clinical work and to prevent suicidal behaviors by increasing health promotion behaviors.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"411-416"},"PeriodicalIF":3.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide risk among residents and PhD students: A systematic review of the literature.","authors":"Marianna Poli, Sophia Russotto, Michele Fornaro, Xenia Gonda, Jorge Lopez-Castroman, Fabio Madeddu, Patrizia Zeppegno, Carla Gramaglia, Raffaella Calati","doi":"10.1016/j.jpsychires.2024.12.013","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.12.013","url":null,"abstract":"<p><p>Residents and PhD students (any discipline) are susceptible to various mental health issues, including suicidal thoughts and behaviors. This systematic review aimed to (1) estimate the prevalence of suicide-related outcomes among residents/PhD students and (2) assess the associated variables. PubMed, PsycINFO, and Scopus databases were searched for articles documenting quantitative information about suicide-related outcomes among residents and PhD students from inception until April 30, 2023. Sixty studies were included. Estimates of the current prevalence of the following suicide-related outcomes were: death wishes (DW), 9.1%; suicidal ideation (SI), 8.6%; suicidal planning (SP), 3.2%; non-suicidal self-injury (NSSI), 1.9%; suicide attempt(s) (SA), .8%. Additionally, estimates of the lifetime prevalence were: lifetime SI (L-SI), 25.9%; lifetime SP (L-SP), 10.0%; lifetime SA (L-SA), 3.1%. Depression, burnout, hopelessness, loneliness, low quality of the relationship with the supervisor and experiencing workplace mistreatment frequently co-occurred with the assessed outcomes. Many outcomes (DW, SI, SP, L-SI, L-SP, L-SA) had a higher prevalence compared to the general population, while some (SI, NSSI, SA) were lower compared to undergraduates. Interventions for individuals at risk in this population are vital together with the modification of the work environment and the promotion of a supportive academic and professional culture to reduce suicide risk.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"433-462"},"PeriodicalIF":3.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The characteristics of event-related potentials in generalized anxiety disorder: A systematic review and meta-analysis.","authors":"Cheng Xie, Chen Xue, Yuxi Li, Xiaobo Liu, Donglin Zhong, Qizu Jin, Juan Li, Rongjiang Jin","doi":"10.1016/j.jpsychires.2024.12.016","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.12.016","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Previous studies have reported inconsistent findings regarding event-related potentials (ERPs) abnormalities in individuals with generalized anxiety disorder (GAD). This meta-analysis aimed to systematically review and synthesize the existing evidence on ERP alterations in individuals with GAD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive literature search was conducted in PubMed, the Cochrane Library, Excerpta Medica Database, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), Wanfang database, and China Biology Medicine (CBM) databases from inception to November 11, 2024. Gray literature and reference lists were also manually searched. Studies investigating ERP component differences between individuals with GAD and healthy controls were included. Two independent reviewers conducted study selection, data extraction, and risk of bias assessment. Influence and sensitivity analyses were performed to assess the robustness of the pooled results. Effect sizes (SMD, Hedge's g) were calculated for latency and amplitude differences. Heterogeneity was assessed using the I&lt;sup&gt;2&lt;/sup&gt; statistic. Meta-regression and subgroup analyses were conducted to explore the source of heterogeneity. Trim-and-fill analyses were applied to assess potential publication bias. Data synthesis was performed using R (version 4.2.3) software.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 37 studies involving 1086 individuals with GAD and 1315 healthy controls were included. The overall risk of bias was rated as low for 25 studies and moderate for 12 studies. Ten ERP components were included in the quantitative meta-analysis: P3, N2, N1, P2, Error Related Negativity (ERN), Correction Related Negativity (CRN), Mismatch Negativity (MMN), P1 (amplitude), Pe, and LPP. Pooled results indicated that individuals with GAD exhibited decreased P3 amplitude (g = -0.54, 95% CI: -0.70 to -0.38, I&lt;sup&gt;2&lt;/sup&gt; = 20%, P = 0.22) and increased ERN amplitude (g = -0.42, 95% CI: -0.72 to -0.12, I&lt;sup&gt;2&lt;/sup&gt; = 40%, P = 0.11) compared to healthy controls. In addition, delayed latency of P3 (g = 0.43, 95% CI: 0.09 to 0.78, I&lt;sup&gt;2&lt;/sup&gt; = 75%, P &lt; 0.01), N2 (g = 0.36, 95% CI: 0.11 to 0.62, I&lt;sup&gt;2&lt;/sup&gt; = 30%, P = 0.20), and MMN (g = 0.63, 95% CI: 0.52 to 0.75, I&lt;sup&gt;2&lt;/sup&gt; = 0%, P &lt; 0.0001) was observed in individuals with GAD. Due to the limited number of included studies, the results of N170, N1/P2, N270, N400, VPP, BAEP, P1 (latency), P50, EPN and Nf were summarized narratively. Individuals with GAD were reported to have increased N170, N400, and VPP amplitude and delayed P1 latency compared to healthy controls. Age, sex ratio, sample size, diagnostic criteria, task-related modality, and paradigm were identified as potential influencing factors of ERP characteristics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Individuals with GAD exhibit increased ERN amplitude and decreased P3 amplitude in contrast ","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"470-483"},"PeriodicalIF":3.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of depression, anxiety, and stress symptoms in different trimesters of pregnancy: A meta-analysis and meta-regression.","authors":"Halimatusaadiyah Abdul Aziz, Huda Dianah Binte Yahya, Wen Wei Ang, Ying Lau","doi":"10.1016/j.jpsychires.2024.11.070","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.070","url":null,"abstract":"<p><p>The global prevalence of psychological problems in different trimesters is unclear due to methodological constraints in previous reviews. A precise estimate would be a key first step in raising awareness and allocating resources. This review aims to (1) calculate the global prevalence of depression, anxiety, and stress symptoms during different trimesters and (2) determine the factors influencing their prevalence estimates. A comprehensive search across eight databases was conducted. The meta packages in R software were used to perform meta-analysis, subgroup analysis, and meta-regression analysis. The Newcastle Ottawa Scale was used to assess the study quality, while the Grading of Recommendations, Assessment, Development, and Evaluation method was utilized to assess the certainty of the evidence. A total of 88 studies with 61,719 participants across 48 countries were included. The prevalences of depression, anxiety, and stress symptoms during all trimesters were 27% (95% CI: 23-31), 37% (95% CI: 31-42), and 26% (95% CI: 9-49), respectively. The second trimester had the highest prevalence of depression (30%) and anxiety (28%) symptoms, whereas the third trimester had the highest prevalence of stress symptoms (52%). A series of subgroup and meta-regression analyses revealed that regions, economic levels of the country, setting, the COVID-19 pandemic, and quality of study were significant factors. Most studies were high quality, but the certainty of the evidence was very low. Findings can contribute as evidence to raising awareness about specific psychological problems during different trimesters. Implementing effective policies and launching targeted interventions can help minimize the prevalence.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"528-546"},"PeriodicalIF":3.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}