Journal of psychiatric research最新文献

{"title":"Persistent differences in autistic symptom severity after one year in individuals at clinical high risk of psychosis and with first-episode psychosis","authors":"Hiroshi Komatsu ,&nbsp;Yutaro Sato ,&nbsp;Kazuho Tomimoto ,&nbsp;Goh Onoguchi ,&nbsp;Kaori Sora ,&nbsp;Yoshiaki Shiozawa ,&nbsp;Yumiko Hamaie ,&nbsp;Atsushi Sakuma ,&nbsp;Noriyuki Ohmuro ,&nbsp;Masahiro Katsura ,&nbsp;Fumiaki Ito ,&nbsp;Takashi Ono ,&nbsp;Kazunori Matsumoto ,&nbsp;Hiroaki Tomita","doi":"10.1016/j.jpsychires.2025.05.068","DOIUrl":"10.1016/j.jpsychires.2025.05.068","url":null,"abstract":"<div><h3>Background</h3><div>Autistic symptoms have been shown to influence functional outcomes and prognosis not only in schizophrenia but also in individuals at clinical high-risk of psychosis (CHR-P) and those experiencing their first-episode psychosis (FEP). However, it remains unclear whether these symptoms reflect enduring traits that persist over time or whether they are states that can improve with treatment in CHR-P and FEP. This study aimed to investigate the one-year trajectory of autistic symptoms in individuals at CHR-P and with FEP.</div></div><div><h3>Methods</h3><div>A total of 59 participants who completed a one-year follow-up [CHR-P, n = 34; FEP, n = 25] were categorized into high and low autistic symptom groups based on baseline symptom severity, as assessed by the Positive and Negative Syndrome Scale Autism Severity Score. We then examined changes in psychiatric symptoms, including autistic symptoms, as well as global and cognitive function, between the two groups over one year.</div></div><div><h3>Results</h3><div>After one year of follow-up, psychiatric symptoms other than autistic symptoms, as well as global and cognitive function, improved in both groups. The significant differences in these symptoms and functions at baseline disappeared after one year. However, while autism symptoms demonstrated some improvement from baseline, the significant differences between the high and low autistic symptom groups persisted.</div></div><div><h3>Conclusion</h3><div>These findings suggest that autistic symptoms may exhibit both transient state and enduring traits in individuals at CHR-P and with FEP. Further studies with larger sample sizes and follow-up periods exceeding one year are needed to validate the long-term stability of these symptoms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 176-182"},"PeriodicalIF":3.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of choral singing on depression and anxiety in older adults: A randomized controlled trial","authors":"Ted K.S. Ng ,&nbsp;Zhi Hao Lim ,&nbsp;Michael Todd ,&nbsp;Fei Sun ,&nbsp;Kendra Ray ,&nbsp;Xiang Qi ,&nbsp;Jiuyu Guo ,&nbsp;Kaisy Xinhong Ye ,&nbsp;Andrea B. Maier ,&nbsp;Rathi Mahendran ,&nbsp;Goh Lee Gan ,&nbsp;Maurine Tsakok ,&nbsp;Ee Heok Kua ,&nbsp;Lei Feng","doi":"10.1016/j.jpsychires.2025.05.061","DOIUrl":"10.1016/j.jpsychires.2025.05.061","url":null,"abstract":"<div><h3>Introduction</h3><div>Few randomized controlled trials (RCTs) have investigated the effects of choral singing (CS) on older adults at-risk of cognitive decline and dementia. Extant RCTs on CS also lack an active control arm controlling for non-intervention-specific active components.</div></div><div><h3>Methods</h3><div>In this parallel-arm, open-label RCT, 200 community-dwelling older adults at-risk of cognitive decline were randomized to the treatment arm, i.e., CS, or the active control arm (i.e., health education program, i.e., HEP, matched with non-intervention-specific components). Both arms involved weekly 1-h group sessions held continuously for two years. We examined the <em>a priori</em> registered secondary outcomes, positive screens for depressive and anxiety disorders, at baseline, 1-year, and 2-year time-points, using linear-mixed models with intention-to-treat.</div></div><div><h3>Results</h3><div>Compared to the HEP, CS participants experienced similar decreased odds of positive screens for depressive and anxiety disorders throughout all the time-points, though different trajectories.</div></div><div><h3>Discussion</h3><div>In contrary to previous studies using passive controls reporting positive outcomes, compared to HEP as an active comparator, CS is as effective as HEP in delaying progression to clinically significant depressive and anxiety disorders in at-risk community-dwelling older adults. Our findings highlight the critical importance of incorporating an intervention-components-matched comparison arm in non-pharmacological interventions.</div></div><div><h3>Trial registration</h3><div>Choral Singing For the Prevention of Dementia, <span><span>https://clinicaltrials.gov/study/NCT02919748</span><svg><path></path></svg></span>; Trial Registration: NCT02919748.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 162-168"},"PeriodicalIF":3.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of eveningness with occupational outcomes in mental disorders: the Northern Finland Birth Cohort 1966","authors":"Tuomas Majuri ,&nbsp;Sanna Huikari ,&nbsp;Marko Korhonen","doi":"10.1016/j.jpsychires.2025.05.044","DOIUrl":"10.1016/j.jpsychires.2025.05.044","url":null,"abstract":"<div><h3>Background</h3><div>The impact of mental health and chronotype on occupational outcomes has been examined, most of the studies linking mental disorders and eveningness with unfavourable occupational outcomes. However, no previous studies have explored the significance of chronotype in income and labour market attachment among individuals with mental disorders.</div></div><div><h3>Method</h3><div>Utilizing the Northern Finland Birth Cohort 1966 with linkages to registers and questionnaire data, we compared income and labour market attachment until midlife among individuals with 1) morning or intermediate type (M/I-type) and no mental disorder (reference group), 2) evening type (E-type) and no mental disorder, 3) M/I-type and mental disorder, and 4) E-type and mental disorder by using cross-tabulations and regression analyses. We stratified our analysis by sex.</div></div><div><h3>Results</h3><div>Compared to the reference group, E-types with mental disorders had the lowest cumulative income irrespective of sex. Among females, E-types with mental disorders had the highest risk for poor labour market attachment when compared to the reference group (OR (95 % CI) 2.33 (1.30–4.16)). Among males, M/I-types with mental disorders had heightened odds for poor labour market attachment (OR (95 % CI) 2.25 (1.55–3.27)), whereas for E-types with mental disorders, the risk was slightly non-significant (OR (95 % CI) 2.13 (0.95–4.78)).</div></div><div><h3>Conclusion</h3><div>This study highlights the significance of chronotype in income and labour market attachment among individuals with mental disorders. From the perspectives of healthcare and employers, individual interventions to support work ability should be targeted at E-types with mental disorders, as eveningness may contribute to poorer occupational outcomes in this group.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 29-36"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal perinatal depressive disorders and the risk of attention deficit and hyperactivity disorder in offspring: A linked data study","authors":"Biruk Shalmeno Tusa ,&nbsp;Rosa Alati ,&nbsp;Kim Betts ,&nbsp;Getinet Ayano ,&nbsp;Berihun Dachew","doi":"10.1016/j.jpsychires.2025.05.058","DOIUrl":"10.1016/j.jpsychires.2025.05.058","url":null,"abstract":"<div><h3>Background</h3><div>This study examines the risk of Attention-Deficit/Hyperactivity Disorder (ADHD) in offspring of mothers with perinatal depressive disorders, considering direct and indirect pathways through adverse birth outcomes.</div></div><div><h3>Methods</h3><div>The study employed a retrospective cohort design, utilising administrative-linked health data from New South Wales. Maternal perinatal depressive disorders and offspring ADHD were identified using the International Classification of Diseases, Tenth Revision, Australian Modification (ICD-10-AM .) codes. A generalised linear model with a binomial distribution and log link function was used to estimate the direct association. Additionally, a mediation analysis was conducted to examine the mediating effects of low birth weight, low Apgar scores, and preterm birth on the association between maternal antenatal depressive disorder and offspring ADHD.</div></div><div><h3>Results</h3><div>After adjusting for confounders, offspring of mothers with antenatal, postnatal, and perinatal depressive disorders had 2.10 (95 % CI: 1.46–3.03), 1.80 (95 % CI: 1.11–2.92), and 2.16 (95 % CI: 1.57–2.97) times greater risk of ADHD, respectively. Preterm birth minimally mediated the relationship between antenatal depression and ADHD, accounting for only 0.73 % of the total effect, which was about 45 times smaller than the direct effect. Low birth weight and low Apgar scores did not mediate this relationship.</div></div><div><h3>Conclusion</h3><div>Our study revealed that maternal perinatal depressive disorders are associated with an increased risk of offspring ADHD, with very minimal or no mediating effects from adverse birth outcomes. Therefore, implementing early intervention strategies aimed at improving maternal mental health is crucial to reducing the risk of ADHD in children.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 169-175"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of treatment on the quality of life of patients with obsessive-compulsive disorder: systematic review and meta-analysis","authors":"Samara dos Santos-Ribeiro ,&nbsp;Gabriela B. de Menezes ,&nbsp;Maria E. Moreira-de-Oliveira ,&nbsp;Verônica Hühne ,&nbsp;Pedro P. Fortes ,&nbsp;Leonardo F. Fontenelle","doi":"10.1016/j.jpsychires.2025.05.036","DOIUrl":"10.1016/j.jpsychires.2025.05.036","url":null,"abstract":"<div><div>This systematic review and meta-analysis investigated whether treatments for obsessive-compulsive disorder (OCD) are associated not only with decreases in symptom severity but also with improvements in quality of life (QoL). A systematic search of PUBMED, PsycInfo, Scopus, Web of Science and ClinicalTrials databases was performed. The inclusion criteria involved RCTs that investigated adults diagnosed with OCD and incorporated evaluations of baseline and endpoint assessments for QoL and OCD symptom severity. The search found 3872 records, with 19 remaining after all screening process. Most of the studies investigated psychological interventions, categorizable into clusters of CBT-based treatments, interventions with meditation components, and augmentation strategies. This categorization was utilized to perform subgroup analysis. All subgroup interventions had a non-significant effect on QoL, except for CBT-based treatments, which demonstrated a statistically significant difference when compared to waiting lists. Regarding the effect of the interventions on the severity of OCD symptoms, the effect sizes were small for CBT-based treatments and medium for interventions with meditation components and augmentation strategies. The CBT-based treatments lead to some improvement in QoL of people with OCD (when compared to no treatment). Evidence suggested that treatments incorporating meditation components or augmentation treatments lead to improvements in OCD symptoms unparalleled by QoL improvement. Further studies are needed to assess pre- and post-intervention QoL measures for a more robust conclusion. This can facilitate the identification of more beneficial and effective treatments, both in reducing symptoms and improving QoL.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 19-28"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of probiotics, prebiotics, and synbiotics on depression and anxiety symptoms of patients with depression: A systematic review and meta-analysis","authors":"Reza Moshfeghinia ,&nbsp;Hossein Nemati ,&nbsp;Asal Ebrahimi ,&nbsp;Dorsa Shekouh ,&nbsp;Saeed Karami ,&nbsp;Mohammad Mirahmadi Eraghi ,&nbsp;Hoorad Mohagheghzadeh ,&nbsp;Jennifer Hunter ,&nbsp;Mehdi Pasalar","doi":"10.1016/j.jpsychires.2025.05.053","DOIUrl":"10.1016/j.jpsychires.2025.05.053","url":null,"abstract":"<div><h3>Introduction</h3><div>Depression is a prevalent mental health disorder with significant societal impact and treatment challenges. Recent research on the gut-brain axis has led to interest in probiotics, synbiotics, and prebiotics as potential therapeutic options for depression. This systematic review aims to evaluate their effects and provide evidence-based insights for future research and clinical practice.</div></div><div><h3>Methods</h3><div>Six digital databases (Scopus, PubMed, Web of Science, Cochrane, PsycINFO, and CINAHL complete) were examined for English-language records. Inclusion criteria involved studies assessing the impact of probiotics, prebiotics, and synbiotic on depression and anxiety in individuals with depression. The Cochrane Collaboration's instrument was employed to evaluate the risk of bias. For meta-analysis, random-effects model was favored, and statistical analysis was conducted using Stata software version 17.</div></div><div><h3>Results</h3><div>From initial 4407 studies 19 studies included in meta-analysis. A meta-analysis of 19 studies involving 1405 participants (882 cases and 523 controls) revealed a significant decrease in depression scores among patients receiving probiotics, prebiotics, or synbiotics compared to the control group (SMD: −1.76 [-2.42, −1.10]), despite high heterogeneity between studies (I²: 96.29 %). Similarly, analysis of seven studies with 481 participants (237 cases and 244 controls) showed a significant decrease in anxiety scores for those receiving these supplements (SMD: −1.60 [-2.83, −0.36]), with high heterogeneity between studies (I²: 96.90 %).</div></div><div><h3>Conclusion</h3><div>In conclusion, our meta-analysis indicates that probiotics, prebiotics, or synbiotics significantly reduce depression and anxiety symptoms in patients with depression. Future research should address heterogeneity in diagnosis and intervention types to better understand their efficacy.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 104-116"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic benefit versus epistemic risk: Need for empirical research in psychedelic epistemology","authors":"Lucas F. Borkel ,&nbsp;Jaime Rojas-Hernández ,&nbsp;Domingo J. Quintana-Hernández ,&nbsp;Luis Alberto Henríquez-Hernández","doi":"10.1016/j.jpsychires.2025.05.039","DOIUrl":"10.1016/j.jpsychires.2025.05.039","url":null,"abstract":"<div><div>This paper highlights the ethical and epistemic challenges posed by psychedelic therapy and vindicates the importance of epistemology in the clinical and psychotherapeutic setting. Despite their relative physiological and psychological safety, these substances can induce changes in the beliefs of those who use them, such as paranormal beliefs. To explain the changes in beliefs, we introduced the concept of epistemic criteria (i.e., the principles individuals use to validate and justify their beliefs) and hypothesized that psychedelics may alter beliefs by modifying epistemic criteria. Further research should be conducted to determine this potential and under-researched risk of psychedelic therapy.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 117-125"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is ketamine safe for individuals in higher level of care treatment for eating disorders? Analysis of safety of subanesthetic ketamine in 104 patients","authors":"Elizabeth Wassenaar ,&nbsp;Dan V. Blalock ,&nbsp;Alan Duffy ,&nbsp;Megan Riddle ,&nbsp;Howard Weeks ,&nbsp;Phil Mehler ,&nbsp;Renee D. Rienecke","doi":"10.1016/j.jpsychires.2025.05.055","DOIUrl":"10.1016/j.jpsychires.2025.05.055","url":null,"abstract":"<div><div>Eating disorders are among the most challenging and fatal mental illnesses and, due to the complication of medical instability caused by malnutrition or other disordered eating behaviors, pose unique treatment challenges for patients with co-occurring depression and mood disorders. Randomized control trials have demonstrated “rapid and robust antidepressant effects” of generic ketamine in individuals with treatment-resistant depression and bipolar depression. This paper assesses the medical safety of ketamine as a treatment for co-occurring treatment-resistant depression or bipolar depression in patients in higher levels of care for their eating disorders. A retrospective analysis was conducted on 104 patients receiving higher levels of care for their eating disorder and who had co-occurring treatment-resistant depression or bipolar disorder. Data on medical safety, particularly in the context of medical and nutritional instability, was collected and analyzed. The findings demonstrated that ketamine is a safe intervention for patients with eating disorders and co-occurring treatment-resistant depression or bipolar depression, even in cases where relative medical or nutritional instability was present due to disordered eating behaviors. This paper presents that ketamine can be used safely with medical monitoring in patents with co-occurring eating disorder and treatment-resistant depression or bipolar depression, despite the challenges posed by medical and nutritional instability in this patient population.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 52-56"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mismatch negativity deficits in schizophrenia and bipolar disorder","authors":"Lizhao Du ,&nbsp;Xiong Jiao ,&nbsp;Kai Shi ,&nbsp;Dongyan Mo ,&nbsp;Jie Zhou ,&nbsp;Yuan Shi ,&nbsp;Xiaoqing Zhang ,&nbsp;Zheng Zeng ,&nbsp;Han Li ,&nbsp;Dongxia Duan ,&nbsp;Shanbao Tong ,&nbsp;Junfeng Sun ,&nbsp;Donghong Cui","doi":"10.1016/j.jpsychires.2025.05.037","DOIUrl":"10.1016/j.jpsychires.2025.05.037","url":null,"abstract":"<div><h3>Objectives</h3><div>Numerous studies have demonstrated mismatch negativity (MMN) deficits in schizophrenia (SCZ), and growing evidence suggests similar deficits in bipolar disorder (BPD). However, no large-scale MMN study has been conducted on Chinese patients with SCZ and BPD. This study aims to validate the presence of MMN deficits in SCZ patients and assess whether BPD patients exhibit similar deficits, using a large-scale Chinese cohort.</div></div><div><h3>Methods</h3><div>MMN data, Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scores, and other clinical interview and assessment data were collected from participants (SCZ: n = 208; BPD: n = 144; healthy controls (HC): n = 324). Analysis of covariance (ANCOVA) was used to examine group differences in MMN amplitudes/areas, with age and gender as covariates. Additionally, correlation analyses were performed to explore the relationships between MMN amplitudes/areas and clinical assessments. To further investigate neural processing, event-related spectral perturbation (ERSP) and inter-trial phase coherence (ITC) analyses within the theta and alpha frequency bands were conducted for both standard and deviant stimuli in the duration MMN (dMMN) and frequency MMN (fMMN) paradigms.</div></div><div><h3>Results</h3><div>ANCOVA results for dMMN and fMMN amplitudes/areas, adjusted for age and gender, revealed significantly smaller MMN amplitudes in both SCZ and BPD groups compared to HC. Strong and significant correlations were observed between MMN mean amplitude and peak amplitude/area for both dMMN and fMMN. ERSP and ITC analyses showed that SCZ patients exhibited significantly reduced theta and alpha ITC and ERSP compared to HC. BPD patients also demonstrated reductions in these measures, though to a lesser extent. Negative correlations between MMN mean amplitude and both ERSP and ITC were found across all groups. In SCZ patients, the mean amplitude of dMMN was negatively correlated with RBANS scores.</div></div><div><h3>Conclusions</h3><div>Our results demonstrate MMN deficits in both SCZ and BPD patients within a large Chinese cohort. The ERSP and ITC analyses highlight the importance of theta and alpha oscillations in auditory processing and reveal distinct neural processing differences between clinical groups and HC.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 94-103"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enriched environment mitigates anxiety and depression-like behaviors induced by SNI via restoration of AMPA and NMDA receptors function in mice","authors":"Keman Xie ,&nbsp;Wenxia Duan ,&nbsp;Yuanyuan Xu,&nbsp;Kedong Chen,&nbsp;Xuefeng Zheng,&nbsp;Jifeng Zhang,&nbsp;Fengming Wu,&nbsp;Guoqing Guo","doi":"10.1016/j.jpsychires.2025.05.051","DOIUrl":"10.1016/j.jpsychires.2025.05.051","url":null,"abstract":"<div><h3>Background</h3><div>Chronic pain is well-known for inducing anxiety and depression in humans. Enriched environment (EE) has shown promising effects in alleviating mood disorders; however, the precise mechanisms remain poorly understood. The medial prefrontal cortex (mPFC), a pivotal brain region associated with emotion regulation, particularly through excitatory synaptic transmission, is implicated in the processing of pain-related mood disorders.</div></div><div><h3>Methods</h3><div>First, adult male C57BL/6 mice 6 weeks after spared nerve injury surgery, were subjected to the behavioral tests and dendritic spine morphology staining. Then, 2 weeks after spared nerve injury (SNI), mice were housed in enriched environment, to establish model EE. Behavioral outcomes, dendritic spine maturation, and AMPA and NMDA receptors expression were assessed up to 4 weeks after EE treatment using behavioral tests, Golgi staining, Western blot, and pharmacological experiments.</div></div><div><h3>Results</h3><div>Our results showed that SNI mice exhibit anxiety and depression-like behaviors. Further analysis revealed that SNI mice displayed a significant reduction in mature dendritic spines in the mPFC. After 4 weeks of housekeeping in EE, dendritic complexity, spine maturity, and the expression of AMPAR and NMDAR of SNI mice were restored, leading to a rescue of anxiety and depression-like behaviors. Moreover, pharmacological antagonism of AMPAR or NMDAR, by intraperitoneal injection of AP-5 or CNQX, effectively abolished the alleviating effect of EE on anxiety and depression-like behaviors in SNI mice.</div></div><div><h3>Conclusions</h3><div>Together, our findings uncovered a previously unrecognized AMPAR and NMDAR-dependent mechanism of EE in mitigates anxiety and depression-like behaviors in SNI mice via restoration of mPFC excitatory synaptic transmission.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 74-86"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}