Journal of psychiatric research最新文献

{"title":"Pre-pandemic psychiatric disorders, disease specific polygenic scores, and alcohol consumption patterns during the COVID-19 pandemic","authors":"Lea Arregui Nordahl Christoffersen ,&nbsp;Liam Quinn ,&nbsp;Thorsten Brodersen ,&nbsp;Isabella Loft ,&nbsp;Bitten Aagaard Jensen ,&nbsp;Christian Erikstrup ,&nbsp;Christina Mikkelsen ,&nbsp;DBDS Genetic Consortium,&nbsp;Erik Sørensen ,&nbsp;Henry R. Kranzler ,&nbsp;Kathrine Agergård Kaspersen ,&nbsp;Maria Didriksen ,&nbsp;Sisse Rye Ostrowski ,&nbsp;Thomas Werge ,&nbsp;Dorte Helenius ,&nbsp;Ole B. Pedersen","doi":"10.1016/j.jpsychires.2025.05.016","DOIUrl":"10.1016/j.jpsychires.2025.05.016","url":null,"abstract":"<div><h3>Background</h3><div>Pre-pandemic psychiatric disorders have been associated with elevated alcohol consumption during the COVID-19 pandemic, raising concerns about associated morbidity and mortality; however, insight into the mechanisms is lacking.</div></div><div><h3>Methods</h3><div>In this prospective cohort study with multiple follow-ups of 27,208 participants from the Danish Blood Donor Study, the potential genetic influence on the associations of pre-pandemic alcohol use disorders (AUD) and major depressive disorder (MDD) with pandemic alcohol consumption patterns was assessed in Poisson regression models, using polygenic scores (PGS). Information on pre-pandemic psychiatric disorders was obtained from Danish national health registers, while information on alcohol consumption was obtained through questionnaires.</div></div><div><h3>Results</h3><div>Adjustment for PGSs did not impact the association of pre-pandemic AUD with alcohol consumption patterns during the COVID-19 pandemic at any time points (e.g., unadjusted [B = 0.68; 95 %CI: 0.52; 0.84] vs. adjusted for AUD PGS [B = 0.66; 95 %CI: 0.50; 0.82]. However, higher AUD PGSs were associated with higher alcohol consumption among individuals without pre-pandemic AUD. Pre-pandemic MDD was unrelated to alcohol consumption patterns during the COVID-19 pandemic in all analyses.</div></div><div><h3>Conclusion</h3><div>Genetic liability to AUD was associated with increased alcohol consumption during the COVID-19 pandemic but only among individuals without pre-pandemic AUD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 163-173"},"PeriodicalIF":3.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of duration and intensity of psychological stressors on mental health outcomes","authors":"Nikolai Malykhin ,&nbsp;Joseph Serrano ,&nbsp;Wojciech Pietrasik ,&nbsp;Kathleen Hegadoren","doi":"10.1016/j.jpsychires.2025.05.012","DOIUrl":"10.1016/j.jpsychires.2025.05.012","url":null,"abstract":"<div><div>Chronic psychosocial stress is a major etiological risk factor for major depressive disorder. The main goal of the present study was to investigate the impact of both the intensity (number of daily stressors or severity of chronic stress) and the duration (daily vs chronic) of different stressors on mental health outcomes in healthy adults. One hundred and forty participants were recruited for this study. We measured recent daily stressors, chronic stress level, perceived stress level, and history of childhood maltreatment. Both direct and indirect effects between different stressors and mental health outcomes were analyzed using correlational analysis and structural equation modeling. We found that the duration of stressors was a much stronger predictor of the severity of depression than their intensity, whilst for anxiety both daily and chronic stressors had a stronger impact compared to perceived stress level. Chronic stress level, rather than daily stressors or perceived stress, was the strongest predictor of general distress, depression, and anxiety, whilst both daily and chronic stressors mediated the relationship between childhood maltreatment and mental health outcomes. Our results emphasize the unique role of chronic stress in the development of depression and confirm that the impact of stress on depression is driven by chronic ongoing stress, rather than more recent stressful events or history of childhood maltreatment. These findings suggest that both the duration and intensity of stressors rather than the level of perceived stress alone may have a greater predictive value in determining the effect of stress on anxiety and depression.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 211-222"},"PeriodicalIF":3.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autistic traits in obsessive compulsive disorder: A systematic review and meta-analysis","authors":"Sıla Derin ,&nbsp;Melike Tetik ,&nbsp;Emre Bora","doi":"10.1016/j.jpsychires.2025.05.006","DOIUrl":"10.1016/j.jpsychires.2025.05.006","url":null,"abstract":"<div><h3>Background</h3><div>Several lines of evidence point to a strong association between OCD and autism-spectrum disorder and broader autism phenotype. However, the extent and nature of overlapping autistic traits has not been completely understood.</div></div><div><h3>Method</h3><div>A systematic review in Pubmed and Scopus databases was performed to compare autistic traits between OCD patients and healthy controls (December 1990 to March 2025). A random-effects meta-analyses were conducted.</div></div><div><h3>Results</h3><div>Current meta-analysis included 27 studies consisting of 1677 patients with OCD and 1239 healthy controls. Compared to healthy controls, total autistic traits (<em>g</em> = 1.27, <em>CI</em> = 1.02, 1.53), also ratings in social-communication domain (<em>g</em> = 0.98, <em>CI</em> = 0.66, 1.31), and restricted/repetitive behaviors (RRBs) domain (<em>g</em> = 1.65, <em>CI</em> = 1.27, 2.04) were increased in OCD patients. OCD symptoms were more strongly related to RRBs domain scores (<em>r</em> = 0.34, <em>CI</em> = 0.19, 0.48) than social-communication domain scores (<em>r</em> = 0.18, <em>CI</em> = 0.09, 0.27).</div></div><div><h3>Conclusions</h3><div>OCD is associated with significant increases in both RRBs and social-communication domains. A substantial subset of OCD emerges in youth who have autistic traits, particularly RRBs. In adults, elevated social-communication scores might, at least partly, reflect the effect of chronic OCD symptoms on social functioning rather than true increase in this domain.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 181-191"},"PeriodicalIF":3.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal functional connectivity study of bipolar Disorder: from the view of default mode network and its association with gene expression","authors":"Xuhan Cui ,&nbsp;Yiding Han ,&nbsp;Haohao Yan ,&nbsp;Chunguo Zhang ,&nbsp;Xiaoling Li ,&nbsp;Jiaquan Liang ,&nbsp;Chaohua Tang ,&nbsp;Weibin Wu ,&nbsp;Wen Deng ,&nbsp;Guojun Xie ,&nbsp;Wenbin Guo","doi":"10.1016/j.jpsychires.2025.05.019","DOIUrl":"10.1016/j.jpsychires.2025.05.019","url":null,"abstract":"<div><h3>Objective</h3><div>Abnormal functions involving brain regions within the default mode network (DMN) have been reported in bipolar disorder (BD). However, most previous studies were cross-sectional. Therefore, a longitudinal study was conducted to observe the change trajectory of symptoms and functional connectivity (FC) of DMN in BD patients. Imaging transcriptomics is used for finding spatially transcriptional correlation of FC changes.</div></div><div><h3>Methods</h3><div>Eighty-two BD patients (43 patients finished the follow-up after 3-month medication treatment) and matched 88 healthy controls were included to perform seed-based FC analysis. The correlation between FC alteration and clinical symptoms was explored with multiple regression analysis. Utilizing imaging transcriptomics, genes from the Allen Human Brain Atlas associated with abnormal imaging phenotypes were obtained by spatial Spearman correlation analysis.</div></div><div><h3>Results</h3><div>BD patients exhibited increased FC between the DMN and the orbitofrontal cortex (OFC), left cerebellar Crus II/VIIb, right inferior frontal gyrus, and bilateral anterior cingulate cortex. After treatment, elevated FC of DMN-OFC tended to normalize, while decreased FC within the inferior parietal gyrus (IPG) was observed. Two FC alterations of left IPG were positively associated with the Stroop Color-Word Test (<em>p</em> = 0.0014, 0.0019 respectively). Enrichment analysis suggested association genes were involved in ribosomal function, membrane transport, and enzymatic activity.</div></div><div><h3>Conclusion</h3><div>The findings further suggest that FC of DMN may relate to symptomatic changes and therapeutic mechanisms of BD. Imaging transcriptomics provides a new perspective for researching genetic factors of BD. However, the small sample and single center of this study may impact the representativeness of the results.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 154-162"},"PeriodicalIF":3.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating location-based and object-based inhibition of return in patients with schizophrenia","authors":"Caili Wu ,&nbsp;Paul Dagg ,&nbsp;Carmen Molgat","doi":"10.1016/j.jpsychires.2025.05.007","DOIUrl":"10.1016/j.jpsychires.2025.05.007","url":null,"abstract":"<div><div>Inhibition of return (IOR) is a well-observed effect in attention orienting tasks. People are slower and/or less accurate to detect a target that appeared at a recently attended location than a novel one. Sometimes inhibition can slow the return of attention to a particular object (object-based IOR). Object-based IOR has been demonstrated in both dynamic and static displays. In static displays, presumably object-based IOR can be additive to location-based IOR. Research investigating IOR in patients with schizophrenia have yielded conflicting results. To date no study has examined object-based IOR in patients with schizophrenia. The current study used a cue back to fixation exogenous cuing paradigm with static displays to investigate both location-based and object-based IOR in patients with schizophrenia and healthy controls. The results showed that significant location-based IOR occurred in both groups, with reduced magnitude of IOR in the patient group than in the control group. No additive object-based IOR was observed in either group. Furthermore, IOR in patients did not correlate to their age, education, and symptom severity. However, it is possible that IOR is related to their general cognitive function. Overall, the results support the hypothesis that location-based IOR plays a much more essential role in the inhibitory mechanisms that facilitate visual search.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 101-107"},"PeriodicalIF":3.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(Third-wave) cognitive behavioral therapy for generalized anxiety disorder in adults: A systematic review and Bayesian network meta-analysis","authors":"Xu Dai,&nbsp;Zhongming Zhang,&nbsp;Linghan Sun,&nbsp;Shunshun Zhu,&nbsp;Yunchou Wu,&nbsp;Junwei Lian,&nbsp;Xia Deng","doi":"10.1016/j.jpsychires.2025.05.010","DOIUrl":"10.1016/j.jpsychires.2025.05.010","url":null,"abstract":"<div><div>Generalized anxiety disorder (GAD) imposes a substantial burden on the patient and society. To manage GAD, cognitive behavioral therapy (CBT) is a widely recognized psychotherapeutic approach. Moreover, the third-wave CBTs expand the treatment options and have the potential to positively impact patient outcomes and preferences. However, which CBT protocols or third-wave CBTs are the most effective and appropriate for use in primary care settings remains uncertain. This study explored the short-and long-term relative efficacy of various CBT protocols and third-wave CBTs in reducing GAD symptom severity via a Bayesian network meta-analysis. The meta-analysis comprised 56 studies involving 4388 participants. Combining the initial analysis and sensitivity analysis, the results indicated that among the CBT protocols, Dugas's CBT protocol—which incorporates self-monitoring, education on uncertainty intolerance, assessment of worry beliefs, improvement of problem orientation, and dealing with core fears—demonstrated superior short- and long-term efficacy in reducing GAD symptom severity. Within the third-wave CBTs, the short- and long-term efficacy of acceptance-based therapy for GAD treatment is also notable. The Bayesian meta-regression analysis results showed that whether the therapies or protocols were guided by a clinician significantly moderated the effect size compared with the control group. These findings provide valuable insights for future GAD therapists in selecting appropriate therapies and protocols and a reference for updating GAD treatment guidelines.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 134-143"},"PeriodicalIF":3.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal gland volume measurement in depressed patients","authors":"Leonard Stepansky ,&nbsp;Richard Ruppel ,&nbsp;Lisa Sommerfeld ,&nbsp;Joy Kleiß ,&nbsp;Kaan Türkan ,&nbsp;Sebastian Arndt ,&nbsp;Sebastian Bickelhaupt ,&nbsp;Florian Knoll ,&nbsp;Michael Uder ,&nbsp;Matthias Stefan May","doi":"10.1016/j.jpsychires.2025.05.013","DOIUrl":"10.1016/j.jpsychires.2025.05.013","url":null,"abstract":"<div><h3>Purpose</h3><div>Prior studies have shown contradicting results regarding adrenal gland volume (AGV) in depressed patients, with some reporting significant enlargement and others not. The aim of this study was to retrospectively compare CT image segmentations of the adrenal glands in patients with depression to a control group with stringent exclusion criteria to minimize confounding factors.</div></div><div><h3>Methods</h3><div>We included patients diagnosed with depression (ICD-10: F32/33) who underwent abdominal CT imaging between 2012 and 2022 and did not have any other psychiatric disorders. Diagnoses that could potentially influence AGV were excluded. The resulting 31 depressed patients were compared to a matching control group of 31 patients without depression. The AGV was manually segmented in thin-sliced reconstructions (≤1 mm).</div></div><div><h3>Results</h3><div>Total AGV in the depressed group was 6.78 (5.19–7.56) cm³ compared to 6.90 (5.54–10.05) cm³ in the control group. There was no significant difference in AGV between the two groups after adjusting for age, height, and weight. A positive correlation was observed between AGV and height (r = 0.41, p &lt; 0.001) and weight (r = 0.52, p &lt; 0.001). Males showed significantly larger AGV than females (p ≤ 0.001), and left AGV was significantly larger than right AGV (p &lt; 0.001). Patients within the depressed group who underwent imaging after a suicide attempt showed larger total AGV compared to the control group, though not statistically significant.</div></div><div><h3>Conclusion</h3><div>AGV is not increased in the well-selected cohort of depressed patients in this study, which contrasts with some previous reports in literature. Further multi-centric studies are required to identify potentially influencing factors such as attempted suicide.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 74-79"},"PeriodicalIF":3.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health outcomes following exposure to combat events during the October 7th war in Israeli reserve soldiers","authors":"Leah Shelef ,&nbsp;Ofir Ohayon ,&nbsp;Elad Micheli ,&nbsp;Jacob Rotschield ,&nbsp;Uzi Bechor","doi":"10.1016/j.jpsychires.2025.05.009","DOIUrl":"10.1016/j.jpsychires.2025.05.009","url":null,"abstract":"<div><h3>Background</h3><div>The present study examines specific associations between various war events and probable posttraumatic stress disorder (PTSD) Checklist for DSM-5 [PCL-5] ≥ 33).</div></div><div><h3>Method</h3><div>This cross-sectional study included all 806 IDF reserve soldiers (96.4 % male), mean age 30.26 (SD = 6.89) who sought help from the IDF Combat Stress Reaction Unit (CSRU) between October 7th, 2023, and August 1st, 2024 (10 months), following participation in the October 7th, 2023 War.</div></div><div><h3>Results</h3><div>A significant association emerged between probable PTSD in those who engaged in hand-to-hand combat, which was also linked with negative cognition and arousal symptom clusters. A significant correlation was found between—exposure to dead bodies or human remains and probable PTSD. Such experiences were also associated with the intrusion symptom cluster. The results indicated that being responsible for the death of an enemy combatant showed no significant relationship with probable PTSD, though it was associated only with arousal symptoms. In contrast, being responsible for the death of a noncombatant was significantly linked to probable PTSD and various PTSD symptoms, intrusion, arousal, and negative cognition symptoms.</div></div><div><h3>Conclusion</h3><div>The study highlights the need to assess various combat events in relation to PTSD symptoms and probable PTSD when conducting evaluation and treatment.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 116-122"},"PeriodicalIF":3.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowerment moderates risk for suicide among LGBTQ+ young adults","authors":"Jennifer J. Muehlenkamp ,&nbsp;Laura M. Nagy","doi":"10.1016/j.jpsychires.2025.05.014","DOIUrl":"10.1016/j.jpsychires.2025.05.014","url":null,"abstract":"<div><h3>Introduction</h3><div>There is a great need to examine resilience-based, modifiable protective factors of the established risk-relationship between experiences of discrimination, suicidal thoughts and behaviors, and nonsuicidal self-injury (NSSI) among sexual and gender diverse (SGD) youth. Preliminary studies suggest that psychological empowerment shows promise as a potential protective factor. The current study evaluated whether empowerment moderated the relationship between experiences of sexual and gender discrimination, NSSI, suicide ideation, and past-year suicide attempts.</div></div><div><h3>Methods</h3><div>Three hundred five LGBTQ + -identifying young adults completed an anonymous online survey assessing discriminatory experiences, psychological empowerment, NSSI history, past-year worst-point suicide ideation and suicide attempts. Five moderated regression models were conducted using the PROCESS macro for SPSS.</div></div><div><h3>Results</h3><div>Empowerment significantly moderated the relationship between sexual/gender-discrimination and suicide attempt as well as the relationships between suicide ideation and NSSI on past-year attempts. When empowerment was high, sexual/gender discrimination, suicide ideation, and NSSI were no longer significantly associated with past-year suicide attempts, suggesting a protective effect. Empowerment had a significant, negative relationship with both suicide ideation and NSSI frequency but did not moderate the effect of discrimination experiences on these variables.</div></div><div><h3>Conclusion</h3><div>Empowerment appears to be a viable protective factor for suicide risk among sexual and gender diverse young adults. Interventions that promote the development of a sense of empowerment may help to reduce risk and prevent suicide within this high-risk population.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 62-68"},"PeriodicalIF":3.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal calcium intake during pregnancy and adolescent depressive symptoms: The Kyushu Okinawa Maternal and Child Health Study","authors":"Yoshihiro Miyake ,&nbsp;Hitomi Okubo ,&nbsp;Satoshi Sasaki ,&nbsp;Keiko Tanaka","doi":"10.1016/j.jpsychires.2025.05.018","DOIUrl":"10.1016/j.jpsychires.2025.05.018","url":null,"abstract":"<div><div>To date, no studies have examined the relationship between maternal dietary intake during pregnancy and the risk of depressive symptoms during adolescence in their children. The current prebirth cohort study investigated the association between maternal calcium intake during pregnancy and the risk of depressive symptoms in adolescent children. Study subjects were 873 mother–child pairs. Maternal calcium intake during pregnancy was assessed using a self-administered diet history questionnaire. Adolescent depressive symptoms were defined as a 20-item Center for Epidemiologic Studies Depression Scale score of ≥16. The risk of depressive symptoms was 23.3 % among the 873 adolescents at 13 years of age. Compared with maternal calcium intake during pregnancy in the first quartile, intake in the fourth quartile was independently associated with a reduced risk of depressive symptoms in adolescents; however, the inverse exposure–response relationship was not statistically significant: the adjusted odd ratios (95 % confidence intervals) for depressive symptoms in adolescents in the first, second, third, and fourth quartiles of maternal calcium intake during pregnancy were 1 (reference), 0.63 (0.39−0.99), 0.91 (0.58−1.41), and 0.58 (0.36−0.93), respectively (<em>P</em> for trend = 0.10). The present study found that higher maternal calcium intake during pregnancy was inversely related to depressive symptoms in the adolescents at 13 years. This finding highlights the potential benefits of increasing maternal calcium intake during pregnancy as a means of preventing childhood depressive symptoms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 80-84"},"PeriodicalIF":3.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}