Journal of psychiatric research最新文献

{"title":"Intranasal insulin administration improves anxiety- and depressive-like behaviors in PTSD-exposed rats","authors":"Arezoo Karimzadeh ,&nbsp;Samaneh Nabavifard ,&nbsp;Elmira Beirami ,&nbsp;Neda Valian","doi":"10.1016/j.jpsychires.2025.07.007","DOIUrl":"10.1016/j.jpsychires.2025.07.007","url":null,"abstract":"<div><h3>Background</h3><div>Post-traumatic stress disorder (PTSD) is a debilitating mental illness that arises after experiencing traumatic events. Insulin is involved in several nervous system functions through widespread receptors across the central nervous system (CNS). We aimed to study the effects of intranasally delivered insulin on behavioral impairments in an animal model of PTSD.</div></div><div><h3>Methods</h3><div>The single prolonged stress (SPS) protocol, which involved 2 h of restraint, 20 min of forced swimming, and exposure to vaporized diethyl ether, was used to induce PTSD-like symptoms in adult male rats. Insulin was administered intranasally (1 IU/day, 5 μl in each nostril) for 14 consecutive days. Anxiety- and depressive-like behaviors were evaluated by the elevated plus maze (EPM) and forced swimming test (FST), respectively. Short-term memory (STM) and long-term memory (LTM) were also assessed using passive avoidance. The protein levels of factors involved in oxidative stress and neuroinflammation, neurotrophic factors, and corticosterone were measured in the hippocampus by ELISA.</div></div><div><h3>Results</h3><div>Intranasal administration of insulin reduced anxiety- and depressive-like behaviors and LTM impairment induced by SPS. Increased levels of corticosterone, ROS, and TNFα, and levels and decreased levels of SOD, catalase, BDNF, and GDNF were observed in the hippocampus of PTSD-modeled animals. Insulin could reduce oxidative stress and enhance the levels of neurotrophic factors.</div></div><div><h3>Conclusion</h3><div>These findings suggest that intranasal administration of insulin early after trauma could lead to anxiolytic and antidepressant effects through the likely mechanism of modulating oxidative stress and neurotrophic factors.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 84-91"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The sex-different effect of oxytocin receptor gene methylation on cerebral gray matter structures and clinical symptoms in Korean patients with panic disorder","authors":"Subin Chung ,&nbsp;Hyun-Ju Kim ,&nbsp;Chun Il Park ,&nbsp;Minji Bang ,&nbsp;Sang-Hyuk Lee","doi":"10.1016/j.jpsychires.2025.07.012","DOIUrl":"10.1016/j.jpsychires.2025.07.012","url":null,"abstract":"<div><h3>Background</h3><div>Panic disorder (PD) is sexually dimorphic in its clinical manifestation, possibly due to differences in brain processing of fear and anxiety. Given oxytocin's role in socio-emotional regulation, epigenetic alterations in the oxytocin receptor gene (<em>OXTR</em>) constitute one possible mechanism underlying sexual dimorphism in PD. We investigated the sex difference in cerebral gray matter volume (GMV) and its association with <em>OXTR</em> methylation in PD patients.</div></div><div><h3>Methods</h3><div>Forty-six PD patients (24 women) and 55 healthy controls (HCs; 31 women) underwent a high-resolution T1-weighted magnetic resonance imaging scan and provided peripheral blood samples at baseline. GMV differences were analyzed using FreeSurfer, and <em>OXTR</em> methylation was measured through pyrosequencing. The severity of PD symptoms was assessed using the Panic Disorder Severity Scale (PDSS) and Albany Panic and Phobia Questionnaire (APPQ).</div></div><div><h3>Results</h3><div>PD patients exhibited smaller GMVs in the right frontal pole, post-central gyrus, superior temporal gyrus, parahippocampal gyrus, and left insula compared to HCs, independent of sex. An interaction effect of sex and PD diagnosis was found in the left precuneus; PD women had larger volume than men, and vice versa in HCs. <em>OXTR</em> methylation, lower in PD patients irrespective of sex, correlated negatively with precuneus volume in women. Larger precuneus volume was associated with more severe agoraphobia in PD women, with an inverse correlation discovered in PD men.</div></div><div><h3>Conclusion</h3><div>Epigenetic changes of <em>OXTR</em> may contribute sex-specific brain structure alterations in PD. The inverse association between precuneus volume and agoraphobia severity across sexes highlights the neurobiological basis of the sex-different manifestation of PD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 495-504"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for venous thromboembolism among psychiatric inpatients: a case control study","authors":"Takuto Ishida ,&nbsp;Megumi Shimada ,&nbsp;Masafumi Mizuno ,&nbsp;Takefumi Suzuki ,&nbsp;Hiroyuki Uchida","doi":"10.1016/j.jpsychires.2025.07.001","DOIUrl":"10.1016/j.jpsychires.2025.07.001","url":null,"abstract":"<div><h3>Background</h3><div>Psychiatric inpatients have an increased risk of venous thromboembolism (VTE). While previous studies have identified baseline risk factors among psychiatric inpatients, systematic data on in-hospital risk factors associated with clinical conditions or treatment remain scarce. This study aimed to identify specific risk factors for VTE among psychiatric inpatients.</div></div><div><h3>Methods</h3><div>This retrospective, single-center case-control study was conducted at Tokyo Metropolitan Matsuzawa Hospital, Japan. Using the electronic medical record system, data on patients newly diagnosed with VTE during their hospital stay were extracted as cases. For each case, five age- and sex-matched patients who were hospitalized in the same ward during the same month were selected as controls. Multiple logistic regression analysis was conducted to examine the effects of in-hospital risk factors, including retarded catatonia, physical restraint, seclusion, and use of psychotropics, on incident VTE.</div></div><div><h3>Results</h3><div>During the study period, 11,819 patients were hospitalized. Among them, 108 (0.9 %) patients with VTE, consisting of 37 patients with pulmonary embolism and 71 patients with proximal deep vein thrombosis, were identified. The mean ± SD age of the patients with VTE was 72.5 ± 14.4 years. After adjusting for confounding factors, retarded catatonia (odds ratio [OR]:10.1, 95 % confidence interval [CI]:3.9–25.7, p &lt; 0.001) and physical restraint (OR:6.7, 95 % CI:3.4–13.3, p &lt; 0.001) were significantly associated with a higher risk of VTE. In contrast, the use of anticoagulants was associated with a lower risk (OR:0.3, 95 % CI:0.1–0.6, p = 0.003).</div></div><div><h3>Conclusion</h3><div>Risk factors for VTE among psychiatric inpatients are markedly different from those among medical inpatients. Further research is warranted to identify potential candidates for anticoagulant prophylaxis against VTE during psychiatric inpatient care.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 6-10"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbances, night eating, and depression in patients with binge-eating disorder","authors":"Mina Velimirović ,&nbsp;Marie Campione ,&nbsp;Jamie Manwaring ,&nbsp;Renee D. Rienecke ,&nbsp;Megan Riddle ,&nbsp;Alan Duffy ,&nbsp;Philip S. Mehler ,&nbsp;Thomas E. Joiner","doi":"10.1016/j.jpsychires.2025.07.008","DOIUrl":"10.1016/j.jpsychires.2025.07.008","url":null,"abstract":"<div><div>Patients with binge-eating disorder (BED) frequently also meet the criteria for night-eating syndrome (NES). While both conditions are associated with elevated depression, it is less clear whether different features of night eating, including evening hyperphagia (EH) and nocturnal ingestions (NI), contribute to depression in individuals with a primary diagnosis of BED. Moreover, sleep disturbances, common in patients with BED, are also highly relevant for both NES and depression. Thus, using a sample of patients diagnosed with BED (<em>N</em> = 153), the present study examined the relationships between eating disturbances, including EH and NI, sleep disturbances, including initial insomnia (i.e., difficulty initiating sleep) and nocturnal awakenings, and depression. Initial insomnia, nocturnal awakenings, and EH were significantly associated with depression; NI was not. The results of a hierarchical linear regression showed that initial insomnia and nocturnal awakenings, but not EH, significantly contribute to depression, above and beyond global eating disorder pathology. Together, our results suggest that among patients with BED, in whom eating is already largely disrupted, EH and NI may not pose an additional risk for depression. In contrast, disrupted sleep does seem to confer a risk for depression, suggesting that a careful assessment of sleeping patterns in addition to eating patterns should be imperative in treatment-seeking patients with BED.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 488-494"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between compassion fatigue and suicidality among healthcare workers in the United States","authors":"Sylvia A. Okon,&nbsp;Carson C. Roan,&nbsp;Rachel A. Hoopsick","doi":"10.1016/j.jpsychires.2025.07.017","DOIUrl":"10.1016/j.jpsychires.2025.07.017","url":null,"abstract":"<div><h3>Background</h3><div>The psychological well-being of healthcare workers affects not only their own health but also patient care quality, making it critical to examine the mental health needs of the healthcare workforce. While compassion fatigue (i.e., depersonalization, emotional exhaustion, and career dissatisfaction) and suicidality have been studied separately among healthcare workers, their relationship with each other remains understudied. This study investigates the associations between compassion fatigue and past-year suicidal thoughts, suicide planning, and suicide attempts among a diverse sample of healthcare workers.</div></div><div><h3>Methods</h3><div>We collected cross-sectional data from a sample of U.S. healthcare workers (N = 200). Logistic regression models examined relationships between compassion fatigue and past-year suicidal thoughts, planning, and attempts, separately. Final models controlled for gender and occupational setting (hospital vs. other).</div></div><div><h3>Results</h3><div>Suicidality was prevalent: 14 % of participants reported past-year suicidal thoughts, 6.0 % reported suicide planning, and 3.5 % reported a suicide attempt. Greater compassion fatigue was significantly associated with increased odds of past-year suicidal thoughts (OR = 1.10, 95 % CI: 1.04, 1.16), suicide planning (OR = 1.10, 95 % CI: 1.02, 1.19), and suicide attempts (OR = 1.10, 95 % CI: 1.01, 1.21). After controlling for gender and occupational setting, these associations remained significant for suicidal thoughts (aOR = 1.09, 95 % CI: 1.04, 1.16), suicide planning (aOR = 1.10, 95 % CI: 1.02, 1.19), and suicide attempts (aOR = 1.10, 95 % CI: 1.01, 1.21).</div></div><div><h3>Conclusions</h3><div>Findings suggest that higher compassion fatigue is linked to increased suicidality among healthcare workers, highlighting the need to address compassion fatigue as a potential risk factor.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 1-5"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain microstructure alterations in bipolar disorder subtypes revealed by diffusion kurtosis imaging","authors":"Moto Nakaya ,&nbsp;Kouhei Kamiya ,&nbsp;Ryo Kurokawa ,&nbsp;Akira Kunimatsu ,&nbsp;Yuichi Suzuki ,&nbsp;Shinsuke Koike ,&nbsp;Naohiro Okada ,&nbsp;Kiyoto Kasai ,&nbsp;Osamu Abe","doi":"10.1016/j.jpsychires.2025.07.006","DOIUrl":"10.1016/j.jpsychires.2025.07.006","url":null,"abstract":"<div><div>Bipolar disorder (BD) is often associated with extensive changes in white matter (WM) microstructure. While diffusion tensor imaging (DTI) has been used in BD studies, diffusion kurtosis imaging (DKI) has rarely been explored, particularly concerning the different subtypes of BD. This cross-sectional study compared DTI and DKI metrics of the brain WM in participants with BD type I (BD-I) and II (BD-II) and in healthy controls (HC). The correlation between the diffusion metrics and the clinical scores was examined. In total, 40 patients with BD and 42 HC were enrolled. Diffusion metrics across groups were examined using tract-based spatial statistics. Patients with BD-I showed lower fractional anisotropy and kurtosis values throughout the WM compared with the values found in patients with BD-II and HC. Comparison between the BD subtypes suggested that patients with BD-I had more prominent WM disruption. Diffusion kurtosis imaging analyses demonstrated a greater spatial extent of significant effects across different BD subtypes than could be achieved by DTI. Our results indicated that DKI can enhance the sensitivity to WM microstructural alterations in BD and that this technique can provide valuable insights into the biological differences between BD-I and BD-II.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 505-512"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of theta burst stimulation for bipolar depression: a systematic review and meta-analysis","authors":"Itsuki Terao ,&nbsp;Wakako Kodama","doi":"10.1016/j.jpsychires.2025.07.021","DOIUrl":"10.1016/j.jpsychires.2025.07.021","url":null,"abstract":"<div><h3>Introduction</h3><div>Randomized controlled trials demonstrating the efficacy of theta burst stimulation (TBS) for bipolar depression have been accumulating. However, the previous meta-analysis failed to detect a significant difference in efficacy compared to sham stimulation.</div></div><div><h3>Methods</h3><div>A comprehensive search for randomized controlled trials was carried out using multiple databases, including PubMed, the Cochrane Library, CINAHL, and <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>. A random-effects meta-analysis was employed to assess and compare the antidepressant efficacy, tolerability, and acceptability of TBS versus sham stimulation.</div></div><div><h3>Results</h3><div>A total of 7 randomized sham-controlled trials, encompassing 168 participants, met the inclusion criteria. TBS demonstrated superior antidepressant efficacy over sham stimulation, with a standardized mean difference of 0.67 (95 % confidence interval [CI]: 0.03 to 1.31). The odds ratio (OR) for clinical response favored TBS (OR = 2.93, 95 % CI: 1.32–6.52), while the OR in remission was not statistically significant (OR = 2.12, 95 % CI: 0.85–5.27). Acceptability, assessed by all-cause discontinuation, was comparable between groups (OR = 0.48, 95 % CI: 0.12–1.96).</div></div><div><h3>Conclusions</h3><div>Theta burst stimulation appears to be a promising, effective, and safe treatment for bipolar depression. Further large-scale and long-term randomized controlled trials are warranted.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 47-51"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Effects of an immersive psychosocial training program on depression and well-being: A randomized clinical trial\" [J. Psychiatr. Res. (2022) 150: 292-299].","authors":"Ariel B Ganz, Benjamin Rolnik, Meenakshi Chakraborty, Jacob Wilson, Cyrus Tau, Matthew Sharp, Dallen Reber, George M Slavich, Michael P Snyder","doi":"10.1016/j.jpsychires.2025.06.035","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.06.035","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reading abilities and cognitive processing in grade 3 children with ADHD comorbid with developmental dyslexia","authors":"Zunwei Zhang ,&nbsp;Yang Xue ,&nbsp;Miaoshui Bai ,&nbsp;Hanyu Dong ,&nbsp;Zakaria Ahmed Mohamed ,&nbsp;Tiantian Wang ,&nbsp;Feiyong Jia","doi":"10.1016/j.jpsychires.2025.07.005","DOIUrl":"10.1016/j.jpsychires.2025.07.005","url":null,"abstract":"<div><div>Attention Deficit/Hyperactivity Disorder (ADHD) frequently co-occurs with developmental dyslexia (DD) (ADHD + DD). Children with ADHD + DD manifest low achievement in reading performance and cognitive abilities. There is, however, a lack of research exploring the association between reading abilities and cognitive processing based on the Planning–Attention–Simultaneous–Successive (PASS) theory, particularly in those with ADHD + DD and ADHD subtypes (e.g., the predominantly inattentive subtype (ADHD-I), predominantly hyperactive/impulsive subtype (ADHD-H), and combined subtype (ADHD-C)). In this study, we enrolled a total of 318 grade 3 children (including 99 ADHD + DD, 103 ADHD-I, 7 ADHD-H, 22 ADHD-C and 87 typically developing (TD) children), all of whom were assessed on measures of reading ability and Das-Naglieri Cognitive Assessment System (DN: CAS). Our key findings reveal that ADHD + DD have an imbalance in their intelligence structure, showing a certain advantage in Performance IQ, while their Verbal IQ tends to be relatively weaker. In terms of DN: CAS cognitive processing, children with ADHD-H exhibit impairments exclusively in Planning, while other cognitive domains remain intact. ADHD + DD children not only exhibit the typical characteristics of ADHD, but also show these traits in a more severe, including deficits in Successive processing. Regression analysis revealed that Successive processing might negatively affect character recognition in children with ADHD + DD. The study highlights that in the context of severely low Attention and Planning processing, Successive processing plays a very different and even negative role in reading ability. This needs to be taken into account when designing remedial interventions for children with ADHD + DD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 521-527"},"PeriodicalIF":3.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal dynamics of the wish to live and wish to die signal near-term increases in suicidal thinking in a veteran sample","authors":"Craig J. Bryan,&nbsp;Samantha E. Daruwala,&nbsp;Melanie L. Bozzay","doi":"10.1016/j.jpsychires.2025.06.039","DOIUrl":"10.1016/j.jpsychires.2025.06.039","url":null,"abstract":"<div><div>Preventing suicide is challenging because there are no ways to reliably determine when someone is about transition from a lower to higher risk state. Dynamic interactions between the wish to live (WTL) and die (WTD) may differentiate higher from lower risk suicide states and signal near-term transitions of increasing risk. In this cohort design, clinical trial participants with posttraumatic stress disorder (PTSD) received prompts to complete a brief survey on their phone 4 times per day for 14 consecutive days at pseudorandom times. Participants were asked to rate their WTL, WTD, suicidal desire, and desire for self-preservation using 4 items from the Scale for Suicide Ideation (SSI). Participants were 116 military personnel and veterans diagnosed with PTSD (69.8 % male, 76.7 % White, M age = 47.2 ± 12.1 years). Multilevel dynamical systems modeling revealed that the WTL and WTD changed in coordinated and opposing directions except when suicidal desire was most severe and was about to worsen at the next time point. Under these conditions, WTL and WTD switched to an oscillatory pattern. Temporal patterns in WTL and WTD differ when people report lower versus higher risk suicidal states. Oscillations in WTL and WTD signal near-term worsening of suicidal desire. Multiple qualitatively distinct suicide risk states exist, suggesting suicide risk is categorical, not continuous.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 471-478"},"PeriodicalIF":3.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}