Journal of psychiatric research最新文献

{"title":"Planning and problem solving across multiple psychiatric disorders in young adults","authors":"Raj A. Shetty ,&nbsp;Jon E. Grant","doi":"10.1016/j.jpsychires.2026.01.059","DOIUrl":"10.1016/j.jpsychires.2026.01.059","url":null,"abstract":"<div><h3>Introduction</h3><div>Planning and problem solving, subdomains of executive functioning, are important for daily functioning and clinical outcomes. Although executive functioning encompasses several domains, whether planning-specific deficits are a transdiagnostic feature across psychiatric disorders remains unclear.</div></div><div><h3>Methods</h3><div>Planning and problem solving in 658 young adults aged 18-29 was assessed in a cross-sectional study using the One Touch Stocking of Cambridge (OTS) task, with the number of problems solved correctly on first choice and mean latency to correct response as outcomes. Participants had a diverse range of psychiatric diagnoses, which were determined by structured clinical interviews. Planning and problem solving performance was compared between psychiatric groups and healthy controls using standardized z-scores and Cohen's d effect sizes.</div></div><div><h3>Results</h3><div>Participants with psychiatric diagnoses generally demonstrated impaired planning and problem solving compared to controls. Large effect deficits in problem-solving accuracy were found in obsessive-compulsive disorder (z = −1.32) and trichotillomania (z = −0.87). Moderate effect deficits were observed in agoraphobia, gambling disorder, panic disorder, antisocial personality disorder, compulsive buying disorder, substance abuse, and borderline personality disorder. Trichotillomania also showed the highest planning latency (z = 0.59). Results for diagnostic groups with small sample sizes should be interpreted with caution.</div></div><div><h3>Conclusion</h3><div>These data indicate that planning and problem solving may be impaired in several psychiatric disorders. Future work may wish to examine the contribution of comorbidities and psychoactive substances to the profiles identified.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 1-7"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness-based group therapy for auditory hallucination management in schizophrenia: A randomized controlled trial","authors":"Shuixian Yang ,&nbsp;Wenqing Zhou ,&nbsp;Yingying Qin ,&nbsp;Tao Zheng ,&nbsp;Fengxia Huang ,&nbsp;Chunqun Li ,&nbsp;Jingxin Dai ,&nbsp;Lina Zhou ,&nbsp;Linmin Li ,&nbsp;Fengchun Wu ,&nbsp;Qiubi Tang","doi":"10.1016/j.jpsychires.2026.02.019","DOIUrl":"10.1016/j.jpsychires.2026.02.019","url":null,"abstract":"<div><div>Auditory hallucinations, a core symptom of schizophrenia, affect 50-70% of patients and significantly impair their quality of life. Although multimodal treatments, including pharmacotherapy, psychotherapy, and neuromodulation, are commonly employed, their efficacy remains limited. This randomized controlled trial aimed to assess the effects of Mindfulness-Based Auditory Hallucination Management (MBAHM) on auditory hallucinations, anxiety, depression, and quality of life in patients with schizophrenia. Eighty patients with schizophrenia were randomly assigned to the MBAHM group (n = 40) or the control group (n = 40). The MBAHM group received a 2-h MBAHM intervention twice a week for eight weeks, while the control group received routine treatment and care. Auditory hallucinations, anxiety, depression, and quality of life were assessed at baseline and post-intervention. The results revealed that, compared to both the baseline and the control group, the MBAHM group showed significant reductions in auditory hallucinations, anxiety, and depression, along with improvements in quality of life (p &lt; 0.001). Correlation analyses further indicated significant associations between reductions in auditory hallucination severity, anxiety, and depression, alongside improvements in quality of life. These findings provide preliminary evidence that MBAHM may be an effective complementary approach for managing auditory hallucinations and improving overall well-being in patients with schizophrenia.</div></div><div><h3>Trial registration</h3><div>Chinese Clinical Trial Registry ChiCTR2400088029. Date of registration: August 09, 2024.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 53-60"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide-related metacognitions in psychiatric inpatients admitted after suicide attempt or an acute suicidal crisis: a longitudinal mediation analysis","authors":"Thomas Forkmann ,&nbsp;Tobias Teismann ,&nbsp;Jana Serebriakova ,&nbsp;Jannik Eimen ,&nbsp;Cora Spahn ,&nbsp;Sonja Omlor ,&nbsp;Peer Abilgaard ,&nbsp;Markus Frings ,&nbsp;Ralf Kudling ,&nbsp;Jens Kuhn ,&nbsp;Martin Schaefer ,&nbsp;Norbert Scherbaum ,&nbsp;Heide Glaesmer ,&nbsp;Lena Spangenberg","doi":"10.1016/j.jpsychires.2026.01.061","DOIUrl":"10.1016/j.jpsychires.2026.01.061","url":null,"abstract":"<div><h3>Background</h3><div>The metacognitive model of suicidality suggests that suicide-related metacognitions activate a Cognitive Attentional Syndrome (CAS)—including suicide-specific rumination, attentional fixation, and thought suppression—which may intensify and prolong suicidal ideation. While initial support has emerged from general population samples, longitudinal evidence in high-risk clinical populations remains lacking.</div></div><div><h3>Methods</h3><div>In a multicenter, prospective study, we examined model assumptions in a sample of 184 psychiatric inpatients (M = 37.5 years, 50% male), all admitted following a suicide attempt or severe suicidal crisis. Participants completed baseline assessments prior to discharge and engaged in a 3-week ecological momentary assessment (EMA) protocol measuring suicide-specific rumination, thought suppression, and suicidal intent up to four times daily. Past suicidal ideation and suicide-related metacognitions (positive and negative) were assessed using validated scales.</div></div><div><h3>Results</h3><div>Past suicidal ideation significantly predicted both positive and negative suicide-related metacognitions. These, in turn, prospectively predicted suicide-specific rumination but not thought suppression. Mediation analyses indicated that positive metacognitions mediated the relationship between past suicidal ideation and future suicide-specific rumination. Additionally, suicide-specific rumination—rather than thought suppression—mediated the relationship between suicide-related metacognitions and both intensity and frequency of suicidal intent during the EMA period.</div></div><div><h3>Limitations</h3><div>Attentional fixation was not assessed. EMA compliance averaged 48.3%, and some measures were adapted from preliminary versions.</div></div><div><h3>Conclusions</h3><div>Findings provide the first longitudinal support for the metacognitive model of suicidality in a clinical sample. Suicide-specific rumination and positive metacognitions may be important drivers of intensification and prolongation of suicidal ideation and suicidal intent formation in the high-risk post-discharge period.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 44-52"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between handgrip strength and incident depression: a meta-analysis of prospective cohort studies","authors":"Jênifer de Oliveira ,&nbsp;Ismael Mignoni ,&nbsp;Davy Vancampfort ,&nbsp;Liye Zou ,&nbsp;Brendon Stubbs ,&nbsp;Aline Josiane Waclawovsky ,&nbsp;Felipe Barreto Schuch","doi":"10.1016/j.jpsychires.2026.02.023","DOIUrl":"10.1016/j.jpsychires.2026.02.023","url":null,"abstract":"<div><div>A number of individual studies have suggested that higher handgrip strength is associated with a lower risk of depressive symptoms but the totality of the evidence remains inconclusive. This study aimed to investigate the association between handgrip strength and the incidence of depressive symptoms or depression and explore potential moderators of this association. We searched major databases (PubMed, Web of Science, PsycINFO, EMBASE, and SportDiscus) from inception to February 4, 2025, for prospective cohort studies evaluating the risk of incident depressive outcomes according to handgrip strength. Effect sizes extracted were the most adjusted model containing odds ratios (ORs) or relative risks (RRs) from individual studies. Random-effects meta-analyses were conducted for ORs and RRs separately, and potential moderators were explored through meta-regressions (% women, sample size, % smokers, age, number of adjustment variables, follow-up time, and person-years). Methodological quality was assessed using the Newcastle–Ottawa Scale. Twelve unique cohorts were included (N = 497,336, person-years = 3,442,910). Individuals with lower handgrip strength had higher odds of incident depressive outcomes (OR = 1.42, 95% CI = 1.14–1.78, p &lt; 0.001). Follow-up time (β = 0.0089, 95% CI = 0.0082–0.0096, R² = 1.00) and person-years (β = 0.00000057, 95% CI = 0.00000028–0.00000086, R² = 0.91) were identified as statistically significant moderators of this association, with studies showing slightly stronger associations, although the magnitude of these effects was small. The average methodological quality score of the studies was 8 (SD = 0.63), indicating overall high quality. This meta-analysis demonstrates a statistically significant but clinically small association between handgrip strength and the incidence of depressive outcomes. These findings suggest that handgrip strength may represent a convenient marker of overall health and functional resilience associated with depression risk.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 106-114"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of common antipsychotic medications with weight gain in youth and adults: a target trial emulation study","authors":"Joshua Petimar ,&nbsp;Sheryl L. Rifas-Shiman ,&nbsp;Jessica G. Young ,&nbsp;Han Yu ,&nbsp;Matthew F. Daley ,&nbsp;William J. Heerman ,&nbsp;David M. Janicke ,&nbsp;W. Schuyler Jones ,&nbsp;Kristina H. Lewis ,&nbsp;Pi-I.D. Lin ,&nbsp;Doug Lunsford ,&nbsp;L. Charles Bailey ,&nbsp;Sengwee Toh ,&nbsp;Jason P. Block","doi":"10.1016/j.jpsychires.2026.02.007","DOIUrl":"10.1016/j.jpsychires.2026.02.007","url":null,"abstract":"<div><h3>Background</h3><div>Few real-world studies have estimated differences in weight gain between antipsychotic medications. This study estimated effects of initiating 4 first-line antipsychotic medications on weight change in adults and children/adolescents.</div></div><div><h3>Methods</h3><div>Electronic health record data were collected from 31,270 adults (≥20 years) and 29,496 children/adolescents (&lt;20 years) newly prescribed 1 of 4 antipsychotics (aripiprazole, olanzapine, quetiapine, risperidone) from 2010 to 2019 across 15 U.S. health systems. Target trial emulation estimated the effect of initiating each medication on weight change in adults and body mass index z-score (BMIz) in children/adolescents at 6 (primary) and 12 months (secondary) versus aripiprazole (reference). Inverse probability weighted estimation of repeated outcome marginal structural models adjusted for baseline confounding and informative outcome measurement.</div></div><div><h3>Results</h3><div>In adults, initiation of aripiprazole was associated with greater 6-month weight change than initiation of olanzapine (difference = −0.60 kg [95% CI: −0.97, −0.25]), quetiapine (difference = −1.17 kg [-1.43, −0.91]), and risperidone (difference = −0.35 kg [-0.73, 0.03]); 12-month weight gain was similar between aripiprazole and olanzapine (difference = −0.11 [-0.61, 0.38]). In children/adolescents, olanzapine was associated with greater 6-month BMIz change than aripiprazole (difference = 0.15 [0.10, 0.20]); quetiapine and risperidone were associated with slightly smaller BMIz increases than aripiprazole. Six-month adherence was lower for olanzapine (5-7%) than other medications (15-21%) in adults and children/adolescents.</div></div><div><h3>Conclusions</h3><div>Among 4 first-line antipsychotic medications, aripiprazole was associated with the greatest 6-month weight gain in adults and olanzapine was associated with the greatest 6-month BMIz increase in children/adolescents, though adherence was lower for olanzapine than other medications. Clinicians should consider these differences in weight gain when initiating antipsychotic medications.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 90-96"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auricular acupressure with five-element music therapy reduces labor pain and short-term postpartum depression: A randomized controlled trial","authors":"Wenjie Sun ,&nbsp;Jie Gong ,&nbsp;Xiuhong Wang,&nbsp;Xianwen Wan,&nbsp;Wei Zheng","doi":"10.1016/j.jpsychires.2026.02.004","DOIUrl":"10.1016/j.jpsychires.2026.02.004","url":null,"abstract":"<div><h3>Background</h3><div>Labor pain and postpartum depression (PPD) are prevalent peripartum complications affecting mothers globally. Conventional interventions for pain management are often limited by contraindications or side effects.</div></div><div><h3>Purpose</h3><div>This study aims to investigate the effects of auricular acupressure combined with five-element music therapy (FEMT) in alleviating labor pain and reducing PPD incidence.</div></div><div><h3>Methods</h3><div>This randomized controlled trial enrolled 146 parturients with singleton cephalic pregnancy preparing for vaginal delivery. Participants were randomly assigned to either the treatment group (auricular acupressure at five points: Internal Genitals, Shenmen, Endocrine, Sympathetic and Subcortex, combined with FEMT) or the control group (routine care). Auricular acupressure was administered during labor until 2 h postpartum, while FEMT involved listening to five-element music. Pain level was evaluated using the Numerical Rating Scale (NRS), and PPD incidence was assessed via Edinburgh Postnatal Depression Scale (EPDS) scores at 1 and 6 weeks postpartum.</div></div><div><h3>Results</h3><div>The treatment group exhibited significantly lower median NRS scores at 6 cm cervical dilation (6 vs. 8, <em>P</em> &lt; 0.001) and 10 cm dilation (7 vs. 9, <em>P</em> &lt; 0.001). At 1 week postpartum, the treatment group had lower EPDS scores (8 vs. 9, <em>P</em> = 0.036), with reduced PPD incidence (15.1% vs. 32.9%, <em>P</em> = 0.012) and major PPD incidence (6.8% vs. 19.2%, <em>P</em> = 0.027). No significant differences in PPD rates were observed at 6 weeks postpartum. Neonatal outcomes and intrapartum cesarean rates were comparable between groups.</div></div><div><h3>Conclusions</h3><div>The combination of auricular acupressure and FEMT effectively alleviated labor pain and reduced short-term PPD incidence.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 71-77"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Temporal patterns of suicide following psychiatric discharge","authors":"Itsuki Terao","doi":"10.1016/j.jpsychires.2026.02.012","DOIUrl":"10.1016/j.jpsychires.2026.02.012","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Page 123"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental bonding and eating disorder core beliefs in a non-clinical sample","authors":"Myra J. Cooper ,&nbsp;Esben Strodl","doi":"10.1016/j.jpsychires.2026.01.027","DOIUrl":"10.1016/j.jpsychires.2026.01.027","url":null,"abstract":"<div><div>This study investigated the relationship between early childhood experiences and eating disorder related core beliefs in the context of cognitive behavioural models of eating disorders highlighting the role of core beliefs or schema. A non-clinical sample of 736 participants (87 % female) was recruited and completed online self report questionnaires. Given the complexity of the relationship between the independent (parental bonding) and dependent (eating disorder related core belief) variables canonical correlation analysis was used to analyse the relationship between the two variable sets. Five functions explained 27.4 % of the variance shared between the two variable sets, and indicated one significant canonical function. Mother and father levels of care and overprotection were the strongest predictors of participant self ratings of the core beliefs self-loathing and abandonment. The results support an association between adverse childhood experiences and negative core beliefs in those with anorexia nervosa and bulimia nervosa, a key link in cognitive behavioural models of eating disorders. It will, of course, be important to seek to replicate this work in a clinical eating disorder sample.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 40-43"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidality calls to a national helpline: One year post the October 7 terror attack and amidst a prolonged war","authors":"Shiri Daniels ,&nbsp;Gil Zalsman ,&nbsp;Liat Itzhaky ,&nbsp;Ohad Szepsenwol ,&nbsp;Ella Sarel Mahlev ,&nbsp;Joy Benatov","doi":"10.1016/j.jpsychires.2026.02.003","DOIUrl":"10.1016/j.jpsychires.2026.02.003","url":null,"abstract":"<div><div>This study provides insights into the impact of prolonged war on suicidality, focusing specifically on suicide-related calls to Israel's national mental health helpline during the year following the October 7, 2023, Hamas terror attack and ongoing war.</div><div>Utilizing data from 615,046 helpline calls between October 7, 2022, and November 2, 2024, the findings showed an immediate, significant increase in overall distress calls after the attack. Conversely, there was a notable and persistent decrease in both the proportion and total number of suicide-related calls throughout the year-long period of war. These findings align with previous research suggesting that heightened war-related distress does not necessarily lead to increased suicide risk, possibly due to factors such as increased social cohesion. Building upon our previous research, the current study contributes to the limited body of knowledge regarding suicidality patterns during prolonged wars. The study underscores the complexity of suicidality patterns during a prolonged war and emphasizes the need for ongoing monitoring and targeted mental health interventions during sustained national crises.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 18-23"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between C-reactive protein and depression among alcohol users in the United States: A population-based analysis of National Health and Nutrition Examination Survey (NHANES) 2015-2020","authors":"Lekshmi Rita-Venugopal ,&nbsp;Tom Varghese M ,&nbsp;Madhav KC","doi":"10.1016/j.jpsychires.2026.02.009","DOIUrl":"10.1016/j.jpsychires.2026.02.009","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation and alcohol use are linked to depression, but whether their effects are independent or interactive remains unclear.</div></div><div><h3>Objective</h3><div>To examine inflammation as an independent correlate of depression among U.S. adults who consume alcohol and a modifier of the alcohol–depression association.</div></div><div><h3>Methods</h3><div>Cross-sectional analysis of NHANES 2015–2020 including adults aged ≥18 reporting past-year alcohol use(n = 3019). Depression was assessed using the PHQ-9, with scores categorized as no depression(0), minimal(1–4), mild(5–9), and moderate–severe(10–27). Inflammation was measured using high-sensitivity CRP, categorized as low(≤1 mg/L), average(1–3 mg/L), and high(&gt;3 mg/L). Alcohol use was classified as light, moderate, or heavy based on drinks/week and binge frequency. Modified Poisson regression with robust variance estimated prevalence ratios for depressive symptoms across CRP levels, adjusting for covariates (alcohol severity, age, sex, race/ethnicity, income, BMI, smoking, physical activity, sleep, comorbidities, drug use). Survey-weighted GLM models tested CRP–alcohol interactions.</div></div><div><h3>Results</h3><div>High CRP was associated with 13% higher mild and 22% higher moderate–severe depression prevalence (p &lt; 0.0001) vs. low CRP. CRP–alcohol interactions were statistically significant with high CRP associated with increased depression prevalence among light drinkers (PR = 1.06,95% CI:1.05–1.07) and moderate drinkers (PR = 1.03,95% CI:1.01–1.04). Among heavy drinkers, high CRP showed an 8.2% increase, not statistically significant, likely due to limited power and dilution by acute inflammation. Sensitivity analyses excluding CRP &gt;10 mg/L showed stronger effects (6–11% increase); high CRP × heavy drinking became significant (PR = 1.11,95% CI:1.05–1.18, p &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>CRP was associated with higher depression and modified alcohol–depression associations. Inflammation amplified depression risk across drinking levels.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 61-70"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}