Journal of psychiatric research最新文献

{"title":"Auricular acupressure with five-element music therapy reduces labor pain and short-term postpartum depression: A randomized controlled trial","authors":"Wenjie Sun ,&nbsp;Jie Gong ,&nbsp;Xiuhong Wang,&nbsp;Xianwen Wan,&nbsp;Wei Zheng","doi":"10.1016/j.jpsychires.2026.02.004","DOIUrl":"10.1016/j.jpsychires.2026.02.004","url":null,"abstract":"<div><h3>Background</h3><div>Labor pain and postpartum depression (PPD) are prevalent peripartum complications affecting mothers globally. Conventional interventions for pain management are often limited by contraindications or side effects.</div></div><div><h3>Purpose</h3><div>This study aims to investigate the effects of auricular acupressure combined with five-element music therapy (FEMT) in alleviating labor pain and reducing PPD incidence.</div></div><div><h3>Methods</h3><div>This randomized controlled trial enrolled 146 parturients with singleton cephalic pregnancy preparing for vaginal delivery. Participants were randomly assigned to either the treatment group (auricular acupressure at five points: Internal Genitals, Shenmen, Endocrine, Sympathetic and Subcortex, combined with FEMT) or the control group (routine care). Auricular acupressure was administered during labor until 2 h postpartum, while FEMT involved listening to five-element music. Pain level was evaluated using the Numerical Rating Scale (NRS), and PPD incidence was assessed via Edinburgh Postnatal Depression Scale (EPDS) scores at 1 and 6 weeks postpartum.</div></div><div><h3>Results</h3><div>The treatment group exhibited significantly lower median NRS scores at 6 cm cervical dilation (6 vs. 8, <em>P</em> &lt; 0.001) and 10 cm dilation (7 vs. 9, <em>P</em> &lt; 0.001). At 1 week postpartum, the treatment group had lower EPDS scores (8 vs. 9, <em>P</em> = 0.036), with reduced PPD incidence (15.1% vs. 32.9%, <em>P</em> = 0.012) and major PPD incidence (6.8% vs. 19.2%, <em>P</em> = 0.027). No significant differences in PPD rates were observed at 6 weeks postpartum. Neonatal outcomes and intrapartum cesarean rates were comparable between groups.</div></div><div><h3>Conclusions</h3><div>The combination of auricular acupressure and FEMT effectively alleviated labor pain and reduced short-term PPD incidence.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 71-77"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Temporal patterns of suicide following psychiatric discharge","authors":"Itsuki Terao","doi":"10.1016/j.jpsychires.2026.02.012","DOIUrl":"10.1016/j.jpsychires.2026.02.012","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Page 123"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidality calls to a national helpline: One year post the October 7 terror attack and amidst a prolonged war","authors":"Shiri Daniels ,&nbsp;Gil Zalsman ,&nbsp;Liat Itzhaky ,&nbsp;Ohad Szepsenwol ,&nbsp;Ella Sarel Mahlev ,&nbsp;Joy Benatov","doi":"10.1016/j.jpsychires.2026.02.003","DOIUrl":"10.1016/j.jpsychires.2026.02.003","url":null,"abstract":"<div><div>This study provides insights into the impact of prolonged war on suicidality, focusing specifically on suicide-related calls to Israel's national mental health helpline during the year following the October 7, 2023, Hamas terror attack and ongoing war.</div><div>Utilizing data from 615,046 helpline calls between October 7, 2022, and November 2, 2024, the findings showed an immediate, significant increase in overall distress calls after the attack. Conversely, there was a notable and persistent decrease in both the proportion and total number of suicide-related calls throughout the year-long period of war. These findings align with previous research suggesting that heightened war-related distress does not necessarily lead to increased suicide risk, possibly due to factors such as increased social cohesion. Building upon our previous research, the current study contributes to the limited body of knowledge regarding suicidality patterns during prolonged wars. The study underscores the complexity of suicidality patterns during a prolonged war and emphasizes the need for ongoing monitoring and targeted mental health interventions during sustained national crises.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 18-23"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental bonding and eating disorder core beliefs in a non-clinical sample","authors":"Myra J. Cooper ,&nbsp;Esben Strodl","doi":"10.1016/j.jpsychires.2026.01.027","DOIUrl":"10.1016/j.jpsychires.2026.01.027","url":null,"abstract":"<div><div>This study investigated the relationship between early childhood experiences and eating disorder related core beliefs in the context of cognitive behavioural models of eating disorders highlighting the role of core beliefs or schema. A non-clinical sample of 736 participants (87 % female) was recruited and completed online self report questionnaires. Given the complexity of the relationship between the independent (parental bonding) and dependent (eating disorder related core belief) variables canonical correlation analysis was used to analyse the relationship between the two variable sets. Five functions explained 27.4 % of the variance shared between the two variable sets, and indicated one significant canonical function. Mother and father levels of care and overprotection were the strongest predictors of participant self ratings of the core beliefs self-loathing and abandonment. The results support an association between adverse childhood experiences and negative core beliefs in those with anorexia nervosa and bulimia nervosa, a key link in cognitive behavioural models of eating disorders. It will, of course, be important to seek to replicate this work in a clinical eating disorder sample.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 40-43"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between C-reactive protein and depression among alcohol users in the United States: A population-based analysis of National Health and Nutrition Examination Survey (NHANES) 2015-2020","authors":"Lekshmi Rita-Venugopal ,&nbsp;Tom Varghese M ,&nbsp;Madhav KC","doi":"10.1016/j.jpsychires.2026.02.009","DOIUrl":"10.1016/j.jpsychires.2026.02.009","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation and alcohol use are linked to depression, but whether their effects are independent or interactive remains unclear.</div></div><div><h3>Objective</h3><div>To examine inflammation as an independent correlate of depression among U.S. adults who consume alcohol and a modifier of the alcohol–depression association.</div></div><div><h3>Methods</h3><div>Cross-sectional analysis of NHANES 2015–2020 including adults aged ≥18 reporting past-year alcohol use(n = 3019). Depression was assessed using the PHQ-9, with scores categorized as no depression(0), minimal(1–4), mild(5–9), and moderate–severe(10–27). Inflammation was measured using high-sensitivity CRP, categorized as low(≤1 mg/L), average(1–3 mg/L), and high(&gt;3 mg/L). Alcohol use was classified as light, moderate, or heavy based on drinks/week and binge frequency. Modified Poisson regression with robust variance estimated prevalence ratios for depressive symptoms across CRP levels, adjusting for covariates (alcohol severity, age, sex, race/ethnicity, income, BMI, smoking, physical activity, sleep, comorbidities, drug use). Survey-weighted GLM models tested CRP–alcohol interactions.</div></div><div><h3>Results</h3><div>High CRP was associated with 13% higher mild and 22% higher moderate–severe depression prevalence (p &lt; 0.0001) vs. low CRP. CRP–alcohol interactions were statistically significant with high CRP associated with increased depression prevalence among light drinkers (PR = 1.06,95% CI:1.05–1.07) and moderate drinkers (PR = 1.03,95% CI:1.01–1.04). Among heavy drinkers, high CRP showed an 8.2% increase, not statistically significant, likely due to limited power and dilution by acute inflammation. Sensitivity analyses excluding CRP &gt;10 mg/L showed stronger effects (6–11% increase); high CRP × heavy drinking became significant (PR = 1.11,95% CI:1.05–1.18, p &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>CRP was associated with higher depression and modified alcohol–depression associations. Inflammation amplified depression risk across drinking levels.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 61-70"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin, social cognition, and neurocognitive function in male patients with schizophrenia: A prospective study","authors":"Şeyma Işık Karakulak ,&nbsp;Süheyla Doğan Bulut ,&nbsp;Hasan Karadağ ,&nbsp;Zeynep Adıyaman Koçer","doi":"10.1016/j.jpsychires.2026.02.013","DOIUrl":"10.1016/j.jpsychires.2026.02.013","url":null,"abstract":"<div><h3>Objective</h3><div>This study examined serum oxytocin levels during an acute psychotic episode and following antipsychotic treatment response in male patients with schizophrenia, and explored associations with social cognition and functional cognitive domains.</div></div><div><h3>Method</h3><div>The sample consisted of 51 male patients meeting DSM-5 criteria for schizophrenia who were assessed during an acute psychotic episode, and 41 healthy male controls. Sociodemographic characteristics, clinical symptoms, and functional status were evaluated using the Sociodemographic and clinical data form(SDVF), Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning (GAF), Cognitive Assessment Interview–Turkish Version (CAI-TR), and Reading the Mind in the Eyes Test (RMET). Serum oxytocin levels were measured using enzyme-linked immunosorbent assay (ELISA). Patients who met the predefined treatment response criterion (≥25% reduction in PANSS total score, N = 33) underwent a second evaluation after a mean follow-up period of 12 weeks.</div></div><div><h3>Results</h3><div>Mean serum oxytocin levels were significantly lower in the patient group (143.94 ± 104.88 pg/mL) than in the control group (254.12 ± 152.58 pg/mL) (t₆₈.₂₈ = 3.93, p &lt; 0.001, d = 0.86). Among the 33 treatment responders, oxytocin levels increased significantly from the acute episode to follow-up (152.55 ± 108.75 to 214.15 ± 115.79 pg/mL; t = 3.27, p = 0.003, d = 0.57). Baseline oxytocin levels were negatively correlated with PANSS Positive and General Psychopathology scores, and positively correlated with RMET and GAF scores. Increases in oxytocin levels following treatment occurred in parallel with improvements, particularly in social cognitive functioning.</div></div><div><h3>Conclusion</h3><div>These findings indicate that oxytocin levels in patients with schizophrenia are associated with social cognitive functioning and increase in parallel with improvements following treatment. Peripheral oxytocin levels may represent a promising candidate biomarker in schizophrenia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 124-131"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in psychiatry: A global perspective on research status, trends and clinical applications","authors":"Zhen Bai ,&nbsp;Chen Bai ,&nbsp;Xiaopeng Yang ,&nbsp;Fang Liu","doi":"10.1016/j.jpsychires.2026.01.060","DOIUrl":"10.1016/j.jpsychires.2026.01.060","url":null,"abstract":"<div><div>Artificial intelligence is increasingly used in psychiatric research, yet progress in clinical use and equitable benefit remains uneven. We analyzed 2795 Web of Science publications on artificial intelligence in psychiatry using bibliometrics and BERTopic based semantic topic modelling. The literature has expanded rapidly since 2012, but output and collaboration are concentrated within a limited set of high-income regions and tightly connected author communities. Across the semantic map, methodological development and diagnosis and monitoring applications occupy central positions, while ethics, governance, and implementation research remain sparse and weakly connected to clinical translation. A temporal gap analysis shows that ethics and regulatory research remained consistently scarce, resulting in a persistent structural gap between clinical applications and ethical governance that widened after 2016. Topic hierarchies also indicate limited representation of older adults, digitally marginalized groups, and low resource settings, which may constrain generalizability and widen disparities. These patterns support a shift toward stronger governance, inclusive data practices, and multisite validation, alongside international collaboration and data sharing approaches that prioritize equity.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"196 ","pages":"Pages 8-17"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: \"Dissociative symptoms in depressive and anxiety disorders: prevalence and clinical correlates in a real-world outpatient sample\".","authors":"Sari Luthfiyah, Padoli Padoli, Jujuk Proboningsih, Mohammed Ismath","doi":"10.1016/j.jpsychires.2026.04.001","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2026.04.001","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to 'Letter to the Editor: Dissociative symptoms in depressive and anxiety disorders: prevalence and clinical correlates in a real-world outpatient sample'.","authors":"Anna Dunalska, Andrzej Jakubczyk, Agata Szulc, Natalia Szejko","doi":"10.1016/j.jpsychires.2026.03.047","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2026.03.047","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet Promise or Missed Potential? A pairwise and network meta-analysis on efficacy and safety of metabotropic glutamate receptor agonists and positive allosteric modulators in schizophrenia","authors":"Archana Mishra ,&nbsp;Amiya Shaju ,&nbsp;Nidhi Surendra Ibrahimpur ,&nbsp;Biswa Ranjan Mishra ,&nbsp;Anand Srinivasan ,&nbsp;Rituparna Maiti","doi":"10.1016/j.jpsychires.2026.01.023","DOIUrl":"10.1016/j.jpsychires.2026.01.023","url":null,"abstract":"<div><h3>Objective</h3><div>Metabotropic glutamate receptor(mGluR) agonists and allosteric modulators like pomaglumetad methionil(POMA) and AZD8529 offer a novel pharmacotherapeutic option in schizophrenia. The results of individual trials on these agents being inconclusive, this meta-analysis was planned to assess the safety and efficacy of mGluR modulators in schizophrenia.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, a systematic search was performed on MEDLINE/PubMed, Embase, Web of Science, Scopus, Cochrane, Google Scholar and WHO-ICTRP, and randomized controlled trials(RCTs) that compared POMA or AZD8529 with either a placebo or second-generation antipsychotics(SGAs) were included. Change in PANSS-Total score was the primary outcome, and PANSS subscales, Clinical Global Impressions-Severity(CGI-S), treatment-emergent adverse events(TEAE) and discontinuation rates were secondary outcomes. A random-effects model was used to estimate the effect size for pairwise and network meta-analysis, and the risk of bias done by RoB2 tool.</div></div><div><h3>Results</h3><div>A total of ten RCTs (3715 participants) were included in the meta-analysis. mGluR modulators did not show significant improvement in PANSS-T (MD:3.20,95 %CI:0.64,5.76) or PANSS-subscales and CGI-S over the control group. The pooled odds ratio for TEAE (OR:1.08; 95 %CI:0.93,1.27) indicates a statistically nonsignificant incidence of adverse events in the experimental group. Discontinuation due to adverse events was higher in the experimental group (OR:1.43; 95 %CI:1.08,1.89), but discontinuation due to lack of efficacy was not significantly different between the groups (OR:1.24,95 %CI:0.86,1.77). Certainty of evidence ranged from high to low. None of the mGluR modulators were better than placebo or SGAs in network meta-analysis.</div></div><div><h3>Conclusion</h3><div>mGluR modulators did not show efficacy in terms of improving symptom severity in schizophrenia. However, their therapeutic potential in specific subgroups may be explored by employing strategic trial designs and relevant biomarkers.</div></div><div><h3>PROSPERO id</h3><div>CRD420251066533</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 52-62"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}