Journal of psychiatric research最新文献

{"title":"Multi-feature fusion method combining brain functional connectivity and graph theory for schizophrenia classification and neuroimaging markers screening","authors":"Chang Wang ,&nbsp;Yaning Ren ,&nbsp;Rui Zhang ,&nbsp;Jiyuan Zhang ,&nbsp;Xiao Li ,&nbsp;Xiangyu Chen ,&nbsp;Jiefen Shen ,&nbsp;Zongya Zhao ,&nbsp;Yongfeng Yang ,&nbsp;Wenjie Ren ,&nbsp;Yi Yu","doi":"10.1016/j.jpsychires.2025.02.025","DOIUrl":"10.1016/j.jpsychires.2025.02.025","url":null,"abstract":"<div><h3>Background</h3><div>The abnormalities in brain functional connectivity (FC) and graph topology (GT) in patients with schizophrenia (SZ) are unclear. Researchers proposed machine learning algorithms by combining FC or GT to identify SZ from healthy controls. The schizophrenia classification and neuroimaging markers screening using FC and GT feature fusion are blank.</div></div><div><h3>Methods</h3><div>We proposed multi-feature fusion method combining functional connectivity and graph topology for schizophrenia classification and neuroimaging markers screening. Firstly, we acquired and preprocessed the private rs-fMRI data from the second affiliated hospital of Xinxiang Medical University in china. Secondly, we calculated the functional connectivity matrix and graph topology features. Thirdly, we used the two-sample <em>t</em>-test and the minimum absolute contraction selection operator (LASSO) to extract the features with statistical differences. Lastly, we used machine learning to classify schizophrenia and screen neuroimaging markers.</div></div><div><h3>Results</h3><div>The result showed that the SVM model with the best feature (i.e., FC and GT) has the best performance (ACC = 0.935(95 percent confidence interval, 0.932 to 0.938), SEN = 0.920(95 percent confidence interval, 0.917 to 0.922), SPE = 0.950(95 percent confidence interval, 0.946 to 0.954), F1 = 0.935(95 percent confidence interval, 0.933 to 0.938), AUC = 0.935(95 percent confidence interval, 0.932 to 0.937)). We also found that the differences in FC and GT features are mainly located in the default network, the attention network, and the subcortical network. The feature strength of FC and GT showed a general decline in patients with SZ, and the node clustering coefficient of the thalamus and the FC of Putamen_L and Frontal_Mid_Orb_R showed an increase.</div></div><div><h3>Conclusion</h3><div>It demonstrated that the multi-feature fusion has the advantage in distinguishing SZ from healthy individuals providing new insights into the underlying pathogenesis of SZ.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 260-268"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does multimodal exercise reduce C-reactive protein levels in major depressive disorder? Preliminary results from a randomized controlled trial","authors":"Vagner Deuel de O. Tavares ,&nbsp;Felipe B. Schuch ,&nbsp;Geovan Menezes de Sousa ,&nbsp;Mats Hallgren ,&nbsp;Megan Teychenne ,&nbsp;Raissa Nóbrega de Almeida ,&nbsp;Rodrigo Vieira Browne ,&nbsp;Maria Luiza Barros ,&nbsp;Renali Camilo Bezerra ,&nbsp;Jaime Eduardo Hallak ,&nbsp;Emerson Arcoverde ,&nbsp;Scott Patten ,&nbsp;Colleen Cuthbert ,&nbsp;Nicole Leite Galvão-Coelho","doi":"10.1016/j.jpsychires.2025.02.023","DOIUrl":"10.1016/j.jpsychires.2025.02.023","url":null,"abstract":"<div><div>This randomized controlled trial aimed to evaluate the adjunctive effects of an affect-based, supervised, multimodal, online, and home-based exercise intervention on C-reactive protein (CRP) levels and depressive symptoms by comparing it to pharmacotherapy alone (antidepressants) over a 12-week period. The study specifically focused on CRP levels and their association with depression outcomes. Depressive symptoms and blood samples were assessed before (baseline – t0), during (Week 5 – t1), and at end of treatment (Week 12 – t2). The exercise intervention was designed to optimize positive affect during and after exercise, and considered each participant's preferred exercise intensity to enhance perceived effort, pleasure, and enjoyment. The study enrolled 59 adults and randomly allocated them into two groups: exercise group (EG; n = 26,76.9% females, mean age 28.5 years) and control group (CG, n = 33, 78.7% females, mean age 25.9 years). CRP levels reduced in the EG at t2 compared with t0 [p = .019; d = .64 (CI 95% −.04,1.24)], while the CRP did not change during treatment in the CG [p = .116; d = −.35 (CI 95% −.93,.16)]. At t2, EG showed clinically meaningful reductions in CRP compared to CG: [p = .043; d = .50 (CI 95% .14,1.30)]. For EG, the anti-inflammatory response predicted reductions in self-reported depressive symptoms (t = 2.066, β = .438, p = .030). Given the significant role inflammation plays in modulating depression symptoms, our findings indicate that structured multimodal exercise programs, which can be delivered online, are effective in the management of depression and potentially have anti-inflammatory.</div></div><div><h3>Trial registration number</h3><div>Brazilian Registry of Clinical Trials (ReBEC: RBR-4pgd3ct); Date of registration: 10/19/2023.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 252-259"},"PeriodicalIF":3.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, age-of-onset, and course of mental disorders among 72,288 first-year university students from 18 countries in the World Mental Health International College Student (WMH-ICS) initiative","authors":"Andre Mason ,&nbsp;Charlene Rapsey ,&nbsp;Nancy Sampson ,&nbsp;Sue Lee ,&nbsp;Yesica Albor ,&nbsp;Ahmad N. Al-Hadi ,&nbsp;Jordi Alonso ,&nbsp;Nouf Al-Saud ,&nbsp;Yasmin Altwaijri ,&nbsp;Claes Andersson ,&nbsp;Lukoye Atwoli ,&nbsp;Randy P. Auerbach ,&nbsp;Caroline Ayuya ,&nbsp;Patricia M. Báez-Mansur ,&nbsp;Laura Ballester ,&nbsp;Jason Bantjes ,&nbsp;Harald Baumeister ,&nbsp;Marcus Bendtsen ,&nbsp;Corina Benjet ,&nbsp;Anne H. Berman ,&nbsp;Claudia van der Heijde","doi":"10.1016/j.jpsychires.2025.02.016","DOIUrl":"10.1016/j.jpsychires.2025.02.016","url":null,"abstract":"<div><h3>Background</h3><div>The college years are a developmentally sensitive period for mental disorder onset. Reliable epidemiological data are critical for informing public health responses. This study aimed to estimate prevalence and socio-demographic distributions of common DSM-5 mental disorders among first-year university students from 77 universities across 18 countries.</div></div><div><h3>Methods</h3><div>Data were collected 2017–2023 in the World Mental Health International College Student Initiative with <em>n</em> = 72,288 university students. Online surveys assessed alcohol use, attention-deficit/hyperactivity, bipolar, drug use, generalized anxiety, major depression, panic, and post-traumatic stress disorders with validated screening scales. Socio-demographics included student age, sex at birth, gender modality, sexual orientation, and parent education.</div></div><div><h3>Results</h3><div>The weighted mean response rate was 20.8%. Data were calibrated for differential response rates by sex at birth and age. 65.2% of respondents screened positive for lifetime mental disorders and 57.4% for 12-month mental disorders. Females had higher prevalence of internalizing disorders and males of substance and attention-deficit/hyperactivity disorders. Older age was associated with lower prevalence of most 12-month but not lifetime mental disorders. Non-heterosexual sexual orientation and identifying as transgender were associated with highest prevalence of most mental disorders. Parent education was for the most part uncorrelated with prevalence.</div></div><div><h3>Conclusions</h3><div>Although prevalence might have been overestimated due to the low response rate and possible screening scale miscalibration, results nonetheless suggest that mental disorders are highly prevalent among first-year university students worldwide and are widely distributed with respect to socio-demographic characteristics. These findings highlight the need to implement effective interventions to better support first-year university student mental health.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 225-236"},"PeriodicalIF":3.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter microstructural subgroups of children with ADHD: Similar clinical presentations and distinct neuropsychological profiles","authors":"Lan-Fang Hu ,&nbsp;Yun-Yu Zhong ,&nbsp;Peng Wang ,&nbsp;Lu Liu ,&nbsp;Xiao-Lan Cao ,&nbsp;Li Sun ,&nbsp;Qing-Jiu Cao ,&nbsp;Li Yang ,&nbsp;Ying Qian ,&nbsp;Yu-Feng Wang ,&nbsp;Bin-Rang Yang ,&nbsp;Zhao-Min Wu","doi":"10.1016/j.jpsychires.2025.02.028","DOIUrl":"10.1016/j.jpsychires.2025.02.028","url":null,"abstract":"<div><h3>Objectives</h3><div>The current study aimed to explore whether it is possible to subgroup ADHD using white matter microstructural characteristics.</div></div><div><h3>Methods</h3><div>In a cohort comprising subjects with ADHD (n = 227) (all aged 6–15 years) and their healthy counterparts (n = 89), the Diffusion Tensor Imaging (DTI) was used to assess fractional anisotropy (FA) in several regions: the body, genu, and splenium of corpus callosum (CC), the bilateral anterior corona radiata, the bilateral internal capsule, and the bilateral superior longitudinal fasciculus. Clinical and neuropsychological profiles were assessed using the ADHD rating scale (ADHD-RS), the Child Behavior Checklist (CBCL), the Behavior Rating Inventory of Executive Function (BRIEF), and CANTAB. Responses to methylphenidate of some of the subjects with ADHD (n = 52) were documented in the Hospital Information System. Cluster analysis was applied to subgroup the ADHD participants. Subsequent between-group comparisons were analyzed using ANCOVA and logistic regression, controlling for age and sex.</div></div><div><h3>Results</h3><div>Cluster analysis stratified the ADHD subjects into two subgroups. Subsequent analysis revealed that there are no significant differences in those behavioral measures from ADHD-RS, CBCL, or BRIEF between the two ADHD subgroups (all P &gt; .05). Compared with the control group, Cluster-2 exhibited lower FA and performed worse on processing speed, while Cluster-1 had higher FA but showed poorer response inhibition and sustained attention. Additionally, Cluster-2 exhibited a superior response to methylphenidate treatment compared to Cluster-1.</div></div><div><h3>Conclusions</h3><div>Although with similar clinical features, ADHD participants could be stratified by their microstructural characteristics, which were further linked to distinct cognitive dysfunction and responses to methylphenidate.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 197-203"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The co-occurrence of depression and dissociation: The relevance of childhood trauma","authors":"Hong Wang Fung ,&nbsp;Grace Wing Ka Ho ,&nbsp;Stanley Kam Ki Lam ,&nbsp;Anson Kai Chun Chau ,&nbsp;Vedat Şar ,&nbsp;Colin A. Ross ,&nbsp;Kunhua Lee ,&nbsp;Wai Tong Chien ,&nbsp;Janet Yuen-Ha Wong","doi":"10.1016/j.jpsychires.2025.02.026","DOIUrl":"10.1016/j.jpsychires.2025.02.026","url":null,"abstract":"<div><div>Recent studies showed that dissociation may be common and persistent in people with depression. Dissociation also predicts subsequent depressive symptoms. Both conditions have been linked with trauma exposure. Yet, little is known about the co-occurrence of depression and dissociation. This multi-sample study investigated the co-occurrence of depressive and dissociative symptoms and its relationship with different types of childhood trauma. We analyzed available data from five samples of Chinese adults (N = 2737 in total). Participants completed the same set of measures of depressive and dissociative symptoms and childhood betrayal and non-betrayal trauma. Across samples, between 22.0% and 50.6% of participants with depression exhibited co-occurring dissociation; the majority of participants with dissociation (67.0%–90.2%) presented with depression too. One-way ANCOVA showed that participants who presented with both depression and dissociation reported a statistically significantly higher number of childhood betrayal and non-betrayal trauma types compared to those who had only one or none of these conditions. Exploratory mediation analysis also revealed that dissociative symptoms partly mediated the relationship between childhood trauma and depressive symptoms, regardless of the type of trauma. Findings suggest that the co-occurrence of depressive and dissociative symptoms is associated with childhood trauma. Individuals who report depressive symptoms or seek treatments for a depressive disorder should be screened for dissociation. Further studies on the reliability, validity, clinical features, and intervention needs of the possible dissociative subtype of depression are required.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 157-163"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual abuse history and psychotropic use characteristics of inpatient children and adolescents with major depressive disorders","authors":"Selma Tural Hesapçıoğlu ,&nbsp;Merve Okuyucu ,&nbsp;Şebnem Büşra Altunkalem Uslu ,&nbsp;Cafer Doğan Hacıosmanoğlu ,&nbsp;Mehmet Fatih Ceylan","doi":"10.1016/j.jpsychires.2025.02.020","DOIUrl":"10.1016/j.jpsychires.2025.02.020","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the clinical and psychopharmacologic characteristics of child and adolescent inpatients diagnosed with major depressive disorder (MDD), with and without a history of sexual abuse.</div></div><div><h3>Methods</h3><div>The 337 consecutive patients who were followed up in a University Child and Adolescent Psychiatry inpatient clinic between 2017 and 2019 were evaluated, and 149 were diagnosed with MDD. MDD diagnosed children and adolescents were divided into two groups based on whether they had a history of sexual abuse (n = 44; Group 1) or did not (n = 105; Group 2).</div></div><div><h3>Results</h3><div>The mean age of group 1 was 14.6 ± 1.6 years (range: 6–18) and group 2 was 14.6 ± 2.2 years (range: 6–18). Group 1 had a significantly higher prevalence of psychiatric comorbidities (p = 0.002), non-suicidal self-injury (p = 0.018), domestic violence (p = 0.008), physical (p = 0.008) and emotional abuse history (p = 0.007), and a longer duration of hospitalization (p &lt; 0.0001). Antipsychotic combination therapy (χ² = 10.772; p = 0.005) and total chlorpromazine equivalent doses were also higher in the sexually abused group (Z = −2.749; p = 0.006).</div></div><div><h3>Conclusion</h3><div>These findings suggest that depressive symptoms in sexually abused children and adolescents may be more resistant to psychopharmacological treatment. Further studies are needed to determine whether these differences are attributable to the neurochemical and neuroanatomical effects of trauma or psychiatric comorbidities.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 189-196"},"PeriodicalIF":3.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esketamine reduces the risk of postpartum depression in women undergoing cesarean section: A systematic review and meta-analysis","authors":"Lőrinc Frivaldszky ,&nbsp;Kincső Lőrincz ,&nbsp;Jakub Hoferica ,&nbsp;Péter Hegyi ,&nbsp;Nándor Ács ,&nbsp;Zsolt Melczer ,&nbsp;Péter Fehérvári ,&nbsp;Márton Keszthelyi","doi":"10.1016/j.jpsychires.2025.02.021","DOIUrl":"10.1016/j.jpsychires.2025.02.021","url":null,"abstract":"<div><h3>Background</h3><div>Postpartum depression (PPD) is a prevalent and debilitating disorder that occurs in 14% of women after giving birth.</div></div><div><h3>Objectives</h3><div>We aimed to assess the efficacy and safety of perioperative esketamine for preventing PPD in women undergoing cesarean section.</div></div><div><h3>Search strategy</h3><div>We performed a systematic literature search in five medical databases - MEDLINE, Cochrane Library, Embase, Scopus, and Web of Science on the 12th of January 2025.</div></div><div><h3>Selection criteria</h3><div>We searched for trials on the efficacy and safety of esketamine for preventing PPD.</div></div><div><h3>Data collection and analysis</h3><div>We collected data on rates of PPD, Edinburgh Postnatal Depression Scale (EPDS) scores, and adverse effects. Pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CI) were calculated using a random-effects model.</div></div><div><h3>Results</h3><div>Our systematic search provided 2681 records; we screened 1336 duplicate-free records. A total of 17 eligible studies were identified after title, abstract, and full-text selection. Esketamine administration was associated with a lower rate of PPD at postpartum days 3–7 and 28–42 (OR = 0.43; 95% CI: 0.31–0.59 and OR = 0.59; 95% CI: 0.39–0.87, respectively). Esketamine administration was associated with significantly lower EPDS scores at postpartum days 3–7 (MD = −1.32; 95% CI: 1.84 to −0.80).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that perioperative administration of esketamine was associated with lower PPD rates and lower scores on the EPDS questionnaire and was considered safe compared to placebo/standard care.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 164-173"},"PeriodicalIF":3.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network analysis of obsessive-compulsive symptoms and their comorbidity with other disorders","authors":"Vlasios Brakoulias ,&nbsp;James Elhindi ,&nbsp;Vladan Starcevic","doi":"10.1016/j.jpsychires.2025.02.010","DOIUrl":"10.1016/j.jpsychires.2025.02.010","url":null,"abstract":"<div><h3>Objectives</h3><div>To improve our understanding of the heterogeneity of obsessive-compulsive disorder (OCD) and its comorbidity with other disorders by using network analysis.</div></div><div><h3>Methods</h3><div>An existing data base of 257 participants with a primary diagnosis of OCD and whose symptoms were evaluated using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was subjected to network analysis.</div></div><div><h3>Results</h3><div>The analysis revealed eight clusters of characteristics. Two clusters were too small in numbers to reach any meaningful conclusion. The other six clusters included patients with: 1) contamination and cleaning symptoms with little comorbidity; 2) high prevalence checking symptoms with comorbid depression and anxiety disorders; 3) high prevalence contamination and cleaning symptoms with aggressive obsessions and checking compulsions; 4) high prevalence hoarding symptoms with comorbid depression and anxiety; 5) high prevalence impulsive aggressive, sexual and checking symptoms, hair-pulling and comorbid body dysmorphic disorder; and 6) high prevalence hoarding with impulsive aggressive and checking symptoms with comorbid alcohol use disorder and psychosis.</div></div><div><h3>Conclusions</h3><div>This study highlights the potential role of comorbidity. Contamination/cleaning symptoms were observed to have less psychiatric comorbidity. Symmetry/ordering symptoms did not feature prominently in the symptom clusters, whilst checking compulsions were common to multiple clusters.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 150-156"},"PeriodicalIF":3.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Converging paths: Autistic traits, body image concerns, and disordered eating symptoms in women","authors":"Nora M. Laskowski ,&nbsp;Vanessa C. Jürgensen ,&nbsp;Martin S. Lehe ,&nbsp;Georg Halbeisen ,&nbsp;Georgios Paslakis","doi":"10.1016/j.jpsychires.2025.02.018","DOIUrl":"10.1016/j.jpsychires.2025.02.018","url":null,"abstract":"<div><div>Autistic traits, such as sensory sensitivities and rigid routines, have been linked to body dissatisfaction (BD) and eating disorders (EDs). However, the interplay between autistic traits, fat- and muscularity-related BD, and disordered eating remains underexplored.</div><div>This cross-sectional study examined the relationships between autistic traits, BD, and disordered eating in 298 women. Correlations and mediation analyses, alongside bootstrapping techniques, were used to evaluate relationships between variables.</div><div>Autistic traits were positively associated with “traditional” disordered eating symptoms including food avoidance and selective eating as well as appearance-related aspects of muscle dysmorphia. Autistic traits were positively associated with avoidant-restrictive food intake disorder (ARFID) symptoms. BD was elevated with increasing autistic traits, only in relation to body fat, not muscularity. Only body fat-related BD (BD-F), but not muscularity-related BD (BD-M) mediated the effect of autistic traits on disordered eating symptoms, predicting increases in both ED and body dysmorphic symptoms, as well as reductions in ARFID symptoms.</div><div>Our findings suggest that women with autistic traits may be more susceptible to internalizing socially perpetuated body ideals or to social feedback towards their appearance, as only stereotypically “female-typed” BD-F, but not “male-typed” dissatisfaction with muscularity (BD-M) mediated the link between autistic traits and disordered eating. Implications are discussed.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 204-211"},"PeriodicalIF":3.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends of antipsychotic utilization patterns in 62,607 patients with schizophrenia-spectrum disorders in Hong Kong: An 11-year population-based study with joinpoint regression analysis","authors":"Catherine Zhiqian Fang ,&nbsp;Nicole Lau ,&nbsp;Joe Kwun Nam Chan ,&nbsp;Corine Sau Man Wong ,&nbsp;Wing Chung Chang","doi":"10.1016/j.jpsychires.2025.02.017","DOIUrl":"10.1016/j.jpsychires.2025.02.017","url":null,"abstract":"<div><div>Antipsychotics are the mainstay treatment for schizophrenia-spectrum disorders (SSD). Existing data on real-world antipsychotic utilization patterns were primarily derived from Western countries and disregarded specific psychiatric diagnosis. There is limited research in Asia in this respect. This population-based study identified 62,607 patients aged ≥18-years with an SSD diagnosis who redeemed at least one antipsychotic prescription within 2006–2016, using data from health-record database of Hong-Kong public healthcare-services. We calculated annual prescription rates (per 1000 persons) for any antipsychotic, antipsychotic drug-classes (first- or second-generation-antipsychotics, FGAs or SGAs), formulations (oral or long-acting injectable, LAI), and individual antipsychotics. Joinpoint-regression analyses were performed to assess temporal antipsychotic prescription trends, quantified by average-annual-percent-change (AAPC), with 95% confidence-intervals (CIs). Result showed that overall antipsychotic prescription rate declined over time from 84.7% in 2006 to 79.9% in 2016. Oral-SGA use gradually surpassed oral-FGA use, rising from 23.8% in 2006 to 54.1% in 2016. LAI-use was relatively low in prevalence and significantly, albeit modestly, dropped from 23.7% to 18.8% over 11 years (AAPC: −2.20[-2.50 to −1.09]), but LAI-SGA use raised over time (APPC: 12.96 [6.59–19.70]), mainly driven by paliperidone-LAI. Risperidone and olanzapine represented two most frequently-prescribed oral-SGAs, while clozapine prescription rate was generally low (4.3%–6.1%), but showed significant upward trend (AAPC: 3.36[2.95–3.78]) over the study period. Our results affirm significant rising trend of SGA prescription over time. Yet, clozapine and LAIs remained relatively underutilized, indicating discrepancies between clinical-treatment recommendations and real-world prescribing practices. Further investigation is needed to clarify barriers to guideline-concordant practices to optimize treatment outcome.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 144-149"},"PeriodicalIF":3.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}