Journal of psychiatric research最新文献

{"title":"The effect of lavender herbal tea on the mental health of individuals with misophonia: A randomized controlled trial","authors":"Sevgi Koroglu Gokbel ,&nbsp;Gulgun Durat","doi":"10.1016/j.jpsychires.2026.01.028","DOIUrl":"10.1016/j.jpsychires.2026.01.028","url":null,"abstract":"<div><div>Misophonia is a disorder characterized by heightened sensitivity to certain sounds, triggering symptoms such as sympathetic nervous system activation, anger, anxiety, and depression. This study aimed to evaluate the potential role of lavender tea in alleviating these symptoms due to its anxiolytic and antidepressant properties. A single-center, single-blind, randomized clinical trial was conducted with 60 participants aged 18 and over, diagnosed with misophonia. Participants were divided equally into experimental and control groups using block randomization. The experimental group consumed 2 g of lavender tea twice daily for 14 days, while the control group received no intervention. Data were collected using the Misophonia Scale, Beck Depression Inventory II, Anxiety Rating Scale, and Trait Anger Scale and analyzed with SPSS 25.0. Baseline characteristics, including age, gender, marital status, education level, income level, and scores for misophonia, anxiety, depression, and anger, were comparable between groups. The mixed ANOVA results suggested that positive changes were observed in misophonia and related psychological symptoms in the lavender tea group, and that these changes may have been more pronounced compared to the control group. The results suggest that the intervention may correlate with enhancements in misophonia, quality of life, and coping strategies. Lavender tea consumption may have helped alleviate symptoms of misophonia, anxiety, depression, and anger. However, due to the lack of participant blinding and the use of self-report measures, the findings should be interpreted cautiously in terms of placebo effects and expectancy bias.</div></div><div><h3>Registration</h3><div>ClinicalTrials.gov Number (NCT06785649).</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 39-46"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Core insomnia symptoms associated with cognitive flexibility in insomnia disorder: A network analysis","authors":"Shiyan Yang ,&nbsp;Zilu Zhang ,&nbsp;Xu Lei","doi":"10.1016/j.jpsychires.2026.01.029","DOIUrl":"10.1016/j.jpsychires.2026.01.029","url":null,"abstract":"<div><h3>Objective</h3><div>Cognitive flexibility, as a key component of executive function, is often impaired in people with insomnia. This study combined network analysis and multiple linear regression methods aimed to systematically explore the insomnia symptoms associated with cognitive flexibility in individuals with insomnia.</div></div><div><h3>Method</h3><div>Based on 426 insomnia individuals who completed the Insomnia Severity Index (ISI) and the Cognitive Flexibility Inventory (CFI). The network model was construct between ISI items and CFI subdimensions. Furthermore, multiple linear regression analyses were performed to examine the predictive effects of specific insomnia symptoms on the subdimensions of cognitive flexibility.</div></div><div><h3>Results</h3><div>Network analysis revealed that ISI6 (noticeability of impaired quality of life) exhibited the highest node strength and expected influence in the network. Linear regression findings indicated that ISI4 (dissatisfaction about current sleep pattern), ISI6 (noticeability of impaired quality of life) and ISI7 (worry about current sleep pattern) could significantly predict CFI_C; ISI2 (difficulty staying asleep) significantly predicted CFI_A.</div></div><div><h3>Conclusion</h3><div>These findings indicate that impaired quality of life is the core symptom of the “Insomnia-Cognitive Flexibility Network”, and different dimensions of cognitive flexibility may be affected by different insomnia symptoms. This study enhances our understanding of the relationship between insomnia and cognitive flexibility in individuals and suggests new targets for personalized intervention in insomnia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 31-38"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenting style and deliberate self-harm among children and adolescents: A hospital-based case-control study in Japan","authors":"Yoshikazu Komura ,&nbsp;Saiko Ema ,&nbsp;Nobuyuki Nomura ,&nbsp;Keisuke Kodama ,&nbsp;Satoru Takabatake ,&nbsp;Fuminari Misawa ,&nbsp;Hiroyoshi Takeuchi","doi":"10.1016/j.jpsychires.2026.01.025","DOIUrl":"10.1016/j.jpsychires.2026.01.025","url":null,"abstract":"<div><h3>Background</h3><div>Although inappropriate parenting styles have been shown to be associated with deliberate self-harm (DSH), few studies have assessed parenting styles from both the perspectives of patients and their parents.</div></div><div><h3>Methods</h3><div>We conducted a hospital-based case-control study at a psychiatric ward in Japan, including patients aged 7–20 years. Histories of DSH were collected from electronic health records in the hospital. Parenting styles were assessed using the Family Diagnostic Test (FDT), which evaluates parenting style from both the patients' and parents’ perspectives. Multivariable logistic regression was performed to estimate odds ratios (ORs) of DSH by 10 % increase of FDT score, adjusting for age, sex, primary diagnosis, history of abuse, school refusal, the number of previous hospitalizations, and family structure.</div></div><div><h3>Results</h3><div>Of the 272 patients (mean age, 15.2 [SD, 2.4] years; 57.4 % female), 115 (42.3 %) had a history of DSH. Patients who felt rejection from their mothers, avoided contact with their mothers, and felt less attached to their mothers were more likely to have histories of DSH, independent of covariates (sense of rejection, OR = 1.15 [95 %CI, 1.01–1.30]; active avoidance, OR = 1.14 [95 %CI, 1.00–1.29]; emotional closeness, OR = 0.89 [95 % CI, 0.79–1.00]; In contrast, parents’ self-assessments of their parenting style were not significantly associated with DSH.</div></div><div><h3>Conclusions</h3><div>Our findings underscore the importance of patient-reported perceptions for revealing the underlying mechanisms linking parenting style and DSH.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 317-323"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it time for a paradigm shift? Trauma in the development of anorexia nervosa in adolescents","authors":"Katarzyna Jowik-Krzemińska ,&nbsp;Agnieszka Słopień ,&nbsp;Marta Tyszkiewicz-Nwafor","doi":"10.1016/j.jpsychires.2026.01.037","DOIUrl":"10.1016/j.jpsychires.2026.01.037","url":null,"abstract":"<div><h3>Context</h3><div>Anorexia nervosa (AN) in adolescents is a severe disorder with complex aetiology. The role of childhood maltreatment (CM) in the development and course of AN remains unclear. The study aimed to analyse the co-occurrence of CM with the severity of psychopathology in patients with AN and to assess their relationship with the dynamics of clinical improvement.</div></div><div><h3>Methods</h3><div>The study included only girls under 18 years of age: 39 patients hospitalised for the first time with a diagnosis of AN and 43 healthy participants from the control group (CG). Questionnaires were used to assess trauma (CTQ), symptoms of depression (BDI), anxiety (STAI), eating disorders (EAT), impulsivity (BIS), self-harm (NSSI), and suicidal behaviour (SB).</div></div><div><h3>Results</h3><div>The analysis did not reveal any statistically significant differences between the AN and control groups in overall frequency or specific CM subtypes. Despite no differences in trauma exposure, the clinical group showed a significant co-occurrence of emotional abuse with higher levels of self-destructive behaviour and anxiety as a trait, while emotional neglect correlated with anxiety as a state. Notably, the presence of reported trauma did not differentiate patients in terms of response to hospital treatment or rate of symptom reduction.</div></div><div><h3>Conclusions</h3><div>In the sample of adolescent girls studied, the mere occurrence of reported trauma was not a factor differentiating patients with AN from healthy peers, nor was it a negative predictor of early hospital treatment outcomes. These results suggest that although specific forms of emotional abuse may co-occur with a more severe psychopathological picture (anxiety, self-destruction), childhood maltreatment does not necessarily constitute a direct obstacle to symptomatic improvement during the first hospitalisation.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 97-104"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating inhibitory control in test-anxious individuals via tDCS: An ERP study","authors":"Peibing Liu ,&nbsp;Zhaonian Hu ,&nbsp;Renlai Zhou","doi":"10.1016/j.jpsychires.2026.01.055","DOIUrl":"10.1016/j.jpsychires.2026.01.055","url":null,"abstract":"<div><div>Test anxiety is a common emotional problem that often negatively affects academic performance. To examine the potential of transcranial direct current stimulation (tDCS) in modulating neural inhibitory control efficiency in individuals with high test anxiety, this study investigated the intervention effects and underlying neural mechanisms. A total of 42 participants with high or low levels of test anxiety were recruited. Each participant received both active (anodal) and sham tDCS targeting the left dorsolateral prefrontal cortex (DLPFC), while event-related potentials (ERPs) were recorded during a Flanker task that indexes inhibitory control by requiring participants to respond to a central target while ignoring distracting flankers. Results showed that, compared to sham stimulation, active tDCS significantly reduced the amplitude of the P3 component—a late positive potential associated with attentional allocation—in the high test anxiety group, but had no significant effect in the low test anxiety group. These findings suggest that tDCS modulates neural inhibitory control in individuals with high test anxiety by activating the left DLPFC. This study provides electrophysiological evidence for non-invasive neuromodulation as a potential intervention strategy and identifying a promising neural target.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 185-192"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence of autistic symptom differences by severity among individuals at clinical high risk for psychosis and with first-episode psychosis: An 18-month longitudinal follow-up study","authors":"Hiroshi Komatsu ,&nbsp;Yutaro Sato ,&nbsp;Kazuho Tomimoto ,&nbsp;Goh Onoguchi ,&nbsp;Kaori Sora ,&nbsp;Yoshiaki Shiozawa ,&nbsp;Masato Takahama ,&nbsp;Yusuke Utsumi ,&nbsp;Yumiko Hamaie ,&nbsp;Atsushi Sakuma ,&nbsp;Noriyuki Ohmuro ,&nbsp;Masahiro Katsura ,&nbsp;Fumiaki Ito ,&nbsp;Takashi Ono ,&nbsp;Nobuhisa Kanahara ,&nbsp;Kazunori Matsumoto ,&nbsp;Hiroaki Tomita","doi":"10.1016/j.jpsychires.2026.01.033","DOIUrl":"10.1016/j.jpsychires.2026.01.033","url":null,"abstract":"<div><div>Autistic symptoms influence functional outcomes in individuals at high clinical risk for psychosis (CHR-P) and in those with first-episode psychosis (FEP). Our recent findings suggest that these symptoms encompass both enduring trait-like and transient state-like features that improve with treatment over a 12-month period. This study aimed to clarify the long-term course of autistic and non-autistic symptoms by comparing individuals with high and low levels of autistic symptoms at the CHR-P and FEP over an extended 18-month period. Sixty-two participants who completed the 18-month follow-up assessment (CHR-P, n = 37; FEP, n = 25) were included. At baseline, the high autistic symptoms (HA) group exhibited a significantly greater severity of autistic symptoms, more severe non-autistic psychiatric symptoms, and lower global functioning than the low autistic symptoms (LA) group. Over the 12- and 18-month follow-up periods, both groups showed significant improvements in non-autistic psychiatric symptoms and global functioning, and the initial group differences in these domains were no longer statistically significant. In contrast, although the autistic symptoms in the HA group decreased over time, a significant difference in the PAUSS total scores between the HA and LA groups persisted throughout the follow-up. While non-autistic psychiatric symptoms and functional impairments are responsive to treatment, autistic symptoms in individuals with CHR-P and FEP may encompass both modifiable, state-like features, and stable, trait-like characteristics, persisting over an 18-month period. Further research is warranted to elucidate the underlying mechanisms and clinical implications of persistent autistic symptoms in early psychosis.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 219-224"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of mindfulness-based stress reduction therapy on individuals with autism spectrum disorder and their caregivers: A systematic review","authors":"Dandan Luo ,&nbsp;Wenjun Dang ,&nbsp;Jie Luo ,&nbsp;Yuwei Jiang","doi":"10.1016/j.jpsychires.2026.01.052","DOIUrl":"10.1016/j.jpsychires.2026.01.052","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with autism spectrum disorder (ASD) and their caregivers often face challenges such as emotional distress and stress management, which severely impact their quality of life. Mindfulness-Based Stress Reduction (MBSR) holds potential value in emotional regulation; however, there is a lack of systematic evaluation targeting the ASD population, particularly caregivers. This systematic review aims to clarify the clinical effects of MBSR interventions on individuals with ASD and their caregivers, providing a reference for the clinical implementation of targeted interventions.</div></div><div><h3>Method</h3><div>We systematically searched PubMed, the Cochrane Library, Web of Science, Embase, Ovid, and CINAHL databases using predefined search terms and combinations, with supplementary handsearching for relevant literature. The search timeframe covered the period from the establishment of each database to October 1, 2025. This systematic review protocol has been prospectively registered in PROSPERO with the registration number CRD420251159313.</div></div><div><h3>Results</h3><div>A total of 13 clinical studies were included. The results indicate that MBSR demonstrates certain intervention potential for adults with ASD and their caregivers. Specifically, among adults with ASD (N = 8), MBSR may help improve emotional symptoms such as anxiety and depression. For ASD caregivers (N = 4), MBSR has shown preliminary effects in relieving psychological stress and improving emotional states, suggesting that it may provide potential psychological support for this population. It should be noted that only one study in the current evidence focuses on children with ASD, and the adolescent population remains uncovered.</div></div><div><h3>Conclusion</h3><div>Preliminary research suggests that MBSR may hold potential value in improving anxiety and depression symptoms among adults with ASD, as well as alleviating caregiving stress and emotional distress among ASD caregivers. However, due to limitations such as the small number of included studies, limited sample sizes, and high heterogeneity, the current evidence remains insufficient in strength, and conclusions should be interpreted with caution. Future research should focus on conducting larger-scale, high-quality studies to enhance the reliability of findings.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 299-308"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithium treatment and risk of neurocognitive disorders in older patients with bipolar disorder: A systematic review","authors":"Eleni Parlapani ,&nbsp;Anna Kirka ,&nbsp;Vasiliki Holeva ,&nbsp;Stergios Kaprinis","doi":"10.1016/j.jpsychires.2026.01.022","DOIUrl":"10.1016/j.jpsychires.2026.01.022","url":null,"abstract":"<div><h3>Objective</h3><div>Bipolar disorder is a chronic mental illness that requires long-term treatment. Reports from patients of cognitive dulling have prompted research into the impact of long-term Lithium treatment on cognition. The present systematic review aimed to investigate the effects of Lithium on neurocognitive disorder outcomes in older patients with bipolar disorder.</div></div><div><h3>Method</h3><div>A systematic literature search was conducted in four databases: PubMed, Scopus, ScienceDirect and EBSCO. Study inclusion was based on concrete inclusion/exclusion criteria. The literature search and the final study selection were conducted in four stages. Included studies were assessed for quality using the Newcastle-Ottawa Quality Assessment Scale for cohort studies, and the Modifications to the Newcastle-Ottawa Scale for cross-sectional studies.</div></div><div><h3>Results</h3><div>The original search yielded a total of 8285 records. Among these, nine studies were included in the systematic review. Eight out of nine studies did not support an association between Lithium treatment and increased risk of neurocognitive disorders. One study found that the association between bipolar disorder and neurocognitive disorder may be mediated by Lithium treatment.</div></div><div><h3>Conclusion</h3><div>There is no conclusive evidence that long-term Lithium treatment is harmful with respect to neurocognitive outcomes in older patients with bipolar disorder. Beyond its efficacy as a mood-stabilizer, accumulating evidence supports Lithium's neurotrophic effects. To date, there is enough evidence to support Lithium maintenance as a first-line treatment for older patients with bipolar disorder.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 13-20"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of aerobic exercise and computer-based cognitive stimulation in patients with schizophrenia - A randomized controlled trial","authors":"İsmail Koç ,&nbsp;Ebru Akbuğa Koç ,&nbsp;Nilgün Çınar ,&nbsp;Türker Şahiner","doi":"10.1016/j.jpsychires.2026.01.039","DOIUrl":"10.1016/j.jpsychires.2026.01.039","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare of the effects of aerobic exercise (AE) and computer-based cognitive stimulation (CS) in terms of cognition, clinical symptoms, depression, and quality of life (QOL) in patients with schizophrenia.</div></div><div><h3>Methods</h3><div>A total of 58 individuals diagnosed with schizophrenia completed to the study (aerobic exercise group (AEG): n = 18, cognitive stimulation group (CSG): n = 20, control group (CG): n = 20). The AEG participated in a 12-week AE program, whereas the CSG engaged in computer-based CS over the same period. Also, the CG did not receive any intervention. Cognition with Montreal Cognitive Assessment scale and Frontal Assessment Battery, clinical symptoms with Positive and Negative Syndrome Scale, depression with Calgary Depression Scale for Schizophrenia, and QOL with Quality of Life Scale for Schizophrenia Patients scale were assessed at baseline and post-intervention.</div></div><div><h3>Results</h3><div>Within-group improvements were observed in general cognitive function, clinical symptoms, and selected QOL domains in the AEG, whereas the CSG showed significant improvements across cognitive functions, clinical symptoms, depressive symptoms, and multiple QOL domains. In contrast, the CG exhibited significant deterioration in cognitive functions, selected clinical symptoms, depressive symptoms, and certain QOL domains over the 12-week period. Between-group comparisons revealed no statistically significant differences in general cognitive function, executive function, and depression at week 12. However, significant differences were observed in specific PANSS and QOL subscales.</div></div><div><h3>Conclusions</h3><div>These findings suggested that computer-based CS and AE may offer domain-specific and complementary effects in cognitive and clinical domains in PwS.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 123-132"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective chart review on psychiatric manifestations of GLP-1 agonist usage","authors":"Brianna Sa ,&nbsp;Anthony Maristany ,&nbsp;Ashwin Subramaniam ,&nbsp;Nayha Kumbkarni ,&nbsp;Rachel Lange ,&nbsp;Sean Oldak ,&nbsp;Adela-Georgiana Buciuc ,&nbsp;Vanessa Padilla","doi":"10.1016/j.jpsychires.2026.01.042","DOIUrl":"10.1016/j.jpsychires.2026.01.042","url":null,"abstract":"<div><h3>Background</h3><div>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for type 2 diabetes mellitus and obesity. Beyond metabolic effects, GLP-1 signaling influences central pathways involved in mood, reward, and stress regulation, raising interest in possible psychiatric implications.</div></div><div><h3>Methods</h3><div>We conducted a retrospective chart review of adults (≥18 years) prescribed GLP-1 RAs at a private university hospital between January 2021 and April 2024. Demographic, medication, and psychiatric data were extracted from electronic health records. Primary outcomes included stability, improvement, worsening, or new onset of psychiatric disorders during treatment.</div></div><div><h3>Results</h3><div>Among 226 patients (mean age 53.5 years; 66.8 % female; mean BMI 33.6 kg/m²), semaglutide was most frequently prescribed (73 %). The mean treatment duration was 20.2 months, with an average 6.7 % weight loss. Major depressive disorder (MDD) and generalized anxiety disorder (GAD) were most prevalent (68.6 % and 65.9 % of patients, respectively). Most remained stable (MDD: 73.6 %; GAD: 78.5 %). New-onset MDD occurred in 9.0 % and GAD in 8.7 % of affected patients, with mean latencies of 15.8 and 16.8 months, respectively. Adjustment disorder, ADHD, and insomnia also emerged in a subset, with ADHD showing the shortest latency to onset (7.8 months). Rare new-onset alcohol use disorder, trichotillomania, and opioid use disorder were observed.</div></div><div><h3>Conclusions</h3><div>GLP-1 RAs appear psychiatrically well-tolerated for most patients, though new-onset or worsening symptoms occur in a minority, underscoring the need for monitoring, particularly in high-risk populations. Prospective studies are warranted to clarify causality, mechanisms, and potential therapeutic roles in psychiatric care.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"195 ","pages":"Pages 92-96"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}