Journal of psychiatric research最新文献

{"title":"Decreased impulsivity in Schizophrenia: Evidence from self-report and behavioral measures","authors":"Cong Fan ,&nbsp;Huanxin Wang ,&nbsp;Wenhao Xu ,&nbsp;Run Liao ,&nbsp;Faxin Wang ,&nbsp;Wenbo Luo","doi":"10.1016/j.jpsychires.2025.06.026","DOIUrl":"10.1016/j.jpsychires.2025.06.026","url":null,"abstract":"<div><div>Impulsivity contributes to deleterious outcomes among schizophrenia (SZ) patients, and it plays an important role in the diagnostic process. However, impulsivity can be measured in a variety of ways, and previous research has yielded mixed results regarding its relationship with positive and negative symptoms. To address this, we controlled for additional variables (e.g., educational level) and utilized various representative impulsivity measures, including the Barratt Impulsiveness Scale (BIS-11), delay discounting task (DDT), probability discounting task (PDT), and balloon analogue risk task (BART), to assess impulsivity in SZ patients and its association with symptoms. Findings indicated that, except for the probability discounting task, all other measures consistently demonstrated reduced impulsivity in SZ patients. Additionally, impulsivity predicted the severity of SZ symptoms: self-reported impulsivity and emotional regulation difficulties predicted positive symptoms, whereas DDT performance and gender predicted negative symptoms. These results highlight the importance of multidimensional impulsivity assessment in SZ, with distinct impulsivity profiles differentially associated with symptom dimensions, which may guide symptom-specific intervention strategies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 301-310"},"PeriodicalIF":3.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of childhood trauma and adult stress on obsessive-compulsive symptoms: the role of inflammation markers and thalamic functional connectivity","authors":"Chenchen Shao ,&nbsp;Xiao Zhao ,&nbsp;Guoqing Chen ,&nbsp;Yu Wu ,&nbsp;Xiaolu Zhang ,&nbsp;Yue Sun ,&nbsp;Jingzhe Li ,&nbsp;Xuedi Zhang ,&nbsp;Wenjing Jiang ,&nbsp;Na Liu","doi":"10.1016/j.jpsychires.2025.06.024","DOIUrl":"10.1016/j.jpsychires.2025.06.024","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence suggests that childhood trauma and adult stress are significant contributors to the development of obsessive-compulsive disorder (OCD). However, the physiological mechanisms by which trauma and stress influence OCD remain unclear. The aim of this study was to investigate whether inflammation and thalamic functional connectivity mediate the relationship between trauma, stress, and the development of OCD.</div></div><div><h3>Methods</h3><div>A cohort of 105 participants, including 50 individuals with OCD and 55 healthy controls, was assessed using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Childhood Trauma Questionnaire (CTQ), and Perceived Stress Scale (PSS). Resting-state functional MRI and blood plasma analysis were used to measure brain connectivity and inflammatory markers.</div></div><div><h3>Results</h3><div>Significantly higher levels of childhood trauma, stress, and inflammation were observed in the OCD group compared to controls. Elevated inflammatory markers were associated with decreased functional connectivity between thalamic subregions and key cortical areas, including the dorsolateral prefrontal cortex and superior parietal gyrus, which was negatively correlated with the severity of OCD symptoms and childhood trauma. Path analysis suggested that stress mediates the relationship between childhood trauma and OCD symptoms, and thalamic functional connectivity could serve as mediator between inflammatory factor and OCD.</div></div><div><h3>Conclusions</h3><div>These findings highlight the critical role of inflammation and thalamic connectivity in the pathophysiology of OCD, which may partly reveal the pathogenic mechanism of trauma and stress, suggesting potential targets for therapeutic intervention.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 343-351"},"PeriodicalIF":3.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of vocational rehabilitation interventions on depression and work-related outcomes among adults with affective disorders: a systematic review and meta-analysis","authors":"Yi Xuan Chan ,&nbsp;Si Qi Yoong ,&nbsp;Jolene Zi Tong Teo ,&nbsp;Ying Jiang","doi":"10.1016/j.jpsychires.2025.06.013","DOIUrl":"10.1016/j.jpsychires.2025.06.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Achieving and sustaining employment is a critical concern for individuals with mental health disorders, and vocational rehabilitation (VR) may be beneficial. However, existing reviews focus on a wide range of mental illnesses.</div></div><div><h3>Aim</h3><div>This systematic review and meta-analysis evaluated the effectiveness of VR for individuals with affective disorders in improving depressive symptoms, competitive employment, absence duration, and quality of life compared to usual care.</div></div><div><h3>Methods</h3><div>Randomized controlled trials which recruited adults aged 18–65 with depressive disorders or bipolar disorders were included. A random-effects meta-analysis was conducted where applicable.</div></div><div><h3>Data sources</h3><div>Ten databases were systematically searched from inception to November 2023. Grey literature was searched on ProQuest and Google Scholar. The search was updated on March 22, 2024.</div></div><div><h3>Results</h3><div>Thirteen articles describing nine studies (n = 1869 participants) were included; no study involved individuals with bipolar disorders. VR reduced depressive symptoms post-intervention and at short-term follow-up compared to usual care but not at long-term follow-up. Competitive employment, absence duration, and quality of life showed no significant differences.</div></div><div><h3>Conclusion</h3><div>Moderate-quality evidence supports VR's effectiveness in reducing depressive symptoms. Future research should focus on VR for bipolar disorders and incorporate workplace support to improve vocational and quality-of-life outcomes.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 259-276"},"PeriodicalIF":3.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the association of hyperarousal and insomnia symptoms: A network perspective","authors":"Kaixu Zhu ,&nbsp;Shengping Xue","doi":"10.1016/j.jpsychires.2025.06.017","DOIUrl":"10.1016/j.jpsychires.2025.06.017","url":null,"abstract":"<div><h3>Objective</h3><div>Insomnia, a prevalent public health problem, is characterized by hyperarousal; however, evidence on the comparison of associations between insomnia symptoms and different forms of arousal is limited. This study utilizes network analysis to explore the complex associations between insomnia symptoms and hyperarousal and to identify key symptoms.</div></div><div><h3>Methods</h3><div>A total of 1209 participants with non-clinical sleep disorders were included in the study. Hyperarousal was assessed by the Arousal Predisposition Scale (APS) and the Pre-sleep Arousal Scale (PSAS), which encompasses two forms of state arousal (pre-sleep cognitive/somatic arousal). Insomnia symptoms were assessed by Pittsburgh Sleep Quality Index (PSQI). Gaussian graph networks and directed acyclic graphs (DAG) were applied to examine associations between variables and identify key variables.</div></div><div><h3>Results</h3><div>Pre-sleep cognitive arousal is the most important variable in the Gaussian network, acting as a “bridge” between the insomnia symptoms and hyperarousal domains, and serving as the gateway that activates most of the insomnia symptoms and hyperarousal in the DAG. Subjective sleep duration is another key driver in the DAG, marking the starting point for insomnia symptoms, while the use of sleep medication represents the endpoint of the pathway.</div></div><div><h3>Conclusion</h3><div>All forms of hyperarousal are positively associated with insomnia symptoms, and pre-sleep cognitive arousal plays the most important role in the maintenance and activation of the insomnia symptoms-hyperarousal network.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 216-222"},"PeriodicalIF":3.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness after service veteran loneliness and exclusion by veterans and nonveterans in Cyberball","authors":"Daniel J. Morton ,&nbsp;Meaghan C. Mobbs ,&nbsp;George A. Bonanno","doi":"10.1016/j.jpsychires.2025.06.014","DOIUrl":"10.1016/j.jpsychires.2025.06.014","url":null,"abstract":"<div><div>Previous research indicates that many veterans experience challenges when transitioning from military to civilian life, with a significant proportion reporting feelings of social exclusion and loneliness. However, these experiences have been documented primarily through self-report surveys with limited examination of their inter-relationship. The current study addressed this gap using an experimental Cyberball paradigm designed to simulate social exclusion. Specifically, we investigated the relationship between perceived exclusion and loneliness among post-9/11 U.S. military veterans. Veteran participants (<em>N</em> = 191) were randomly assigned to one of four conditions in a 2 (inclusion vs. exclusion) x 2 (veteran vs. nonveteran online confederates) between-subjects design. Results revealed a significant interaction effect, with veterans reporting higher levels of loneliness when excluded by nonveteran confederates compared to when excluded by veteran confederates. Nostalgia for the military and warrior identity were each significantly associated with loneliness but did not moderate the effect of exclusion. These findings provide experimental evidence for the impact of perceived nonveteran exclusion on veteran loneliness and highlight the importance of facilitating veterans' social integration during the transition to civilian life.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 223-230"},"PeriodicalIF":3.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic impact of chronic stress: BDNF exon IV gene methylation in high-risk professionals","authors":"Bárbara Risse Quaioto ,&nbsp;Marcele Lorentz Mattos de Souza ,&nbsp;Aline Ribeiro Borçoi ,&nbsp;Suzanny Oliveira Mendes ,&nbsp;Luiz Cláudio Barreto Silva Neto ,&nbsp;Carlos Henrique Pagani Corrêa ,&nbsp;Ivana Alece Arantes Moreno ,&nbsp;Amanda Sgrancio Olinda ,&nbsp;Ester Ribeiro Cunha ,&nbsp;Pierre Augusto Victor da Silva ,&nbsp;Isabela de Sousa Bianchini Marins ,&nbsp;Anita Vargas de Castro ,&nbsp;Elisa Soares Fassarella ,&nbsp;Bruna Pereira Sorroche ,&nbsp;Lídia Maria Rebolho Batista Arantes ,&nbsp;Sônia Alves Gouvea ,&nbsp;Pedro Luiz Ferro ,&nbsp;Elizeu Batista Borloti ,&nbsp;Adriana Madeira Alvares-da-Silva","doi":"10.1016/j.jpsychires.2025.06.018","DOIUrl":"10.1016/j.jpsychires.2025.06.018","url":null,"abstract":"<div><div>Stress is characterized by homeostatic imbalances caused by factors known as stressors. When faced with a stressor, the body activates the autonomic nervous system, the immune system, and the hypothalamic–pituitary–adrenal axis to restore homeostasis. Repeated exposure to stressful conditions can lead to epigenetic changes. Work-related stressors in high-pressure professions, can influence the epigenetics of key genes involved in brain function, including <em>BDNF</em>. This study investigated the relationship between <em>BDNF</em> DNA methylation and stress in military police officers. A total of 123 military police officers from Metropolitan Region of Grande Vitória, ES, Brazil were recruited to assess whether stress influences methylation by pyrosequencing the <em>BDNF</em> exon IV promoter region. A Generalized Linear Model was used to analyze the effect of stress on methylation levels, controlling for important confounding factors. The results showed that stress was significantly associated with <em>BDNF</em> DNA methylation at CpG 5, CpG 6, and CpG 11 in <em>BDNF</em> exon IV, a region that includes the binding site for the transcription factor CREB. These results indicate that the chance of occurrence of higher levels of methylation was 0.259 times higher at CpG 5, 0.471 times higher at CpG 6, and 0.461 times higher at CpG 11 in military police officers under stress than in those who did not experience stress. Based on these findings, we suggest that stress may act as an environmental pressure factor with implications for <em>BDNF</em> DNA methylation.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 295-300"},"PeriodicalIF":3.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulnerability, perception, and experiences of stress in shift workers","authors":"Soobeen Cha ,&nbsp;So Young Yoo ,&nbsp;Hyewon Yeo ,&nbsp;Yunjee Hwang ,&nbsp;Somi Lee ,&nbsp;Sehyun Jeon ,&nbsp;Seog Ju Kim","doi":"10.1016/j.jpsychires.2025.06.015","DOIUrl":"10.1016/j.jpsychires.2025.06.015","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore stress vulnerability, perceived stress, and stressful experiences of shift workers (SWs) and non-shift workers (NSWs) and their association with sleep, mood, and workplace environments.</div></div><div><h3>Methods</h3><div>An online self-reported survey was conducted which included 4561 SWs and 2093 NSWs. Participants completed the Stress Vulnerability Scale (SVS), Perceived Stress Scale (PSS), Global Assessment of Recent Stress (GARS) scale, short form of the Center for Epidemiologic Studies Depression Scale (CES-D), Pittsburgh Sleep Quality Index (PSQI), and Korean Occupational Stress Scale (KOSS).</div></div><div><h3>Results</h3><div>SWs demonstrated higher SVS, PSS, and GARS scores than NSWs after adjusting for age, gender, income, education, working hours, and occupations. SWs and NSWs showed no significant differences in SVS and PSS after additionally adjusting for PSQI or KOSS. SVS demonstrated no between-group differences when CES-D was additionally adjusted, but a significant difference remained in PSS. Between-group differences in GARS remained significant after additionally adjusting for PSQI, KOSS, or CES-D. The association between PSQI and GARS and between KOSS and PSS was stronger in SWs than in NSWs.</div></div><div><h3>Conclusions</h3><div>SWs demonstrated greater vulnerability to stress, higher perceived stress levels, and more frequent stressful experiences compared to NSWs. Increased stress vulnerability and perceived stress in SWs were associated with sleep and workplace environments. SWs showed a more prominent association between sleep and stressful experiences and between workplace environments and perceived stress than NSWs.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 252-258"},"PeriodicalIF":3.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of mechanical restraint and the role of verbal de-escalation techniques in patients with schizophrenia during involuntary hospital transfer","authors":"David Córcoles ,&nbsp;Francesc Casanovas ,&nbsp;Jordi León ,&nbsp;Agnés Sabaté ,&nbsp;Sonia Ramos ,&nbsp;Pilar Samos ,&nbsp;Miguel Angel Jerónimo ,&nbsp;Victor Pérez ,&nbsp;Luis Miguel Martín","doi":"10.1016/j.jpsychires.2025.06.016","DOIUrl":"10.1016/j.jpsychires.2025.06.016","url":null,"abstract":"<div><div>Mechanical restraint (MR) is a significant ethical and clinical concern in psychiatric care and should be avoided whenever possible. A commonly recommended strategy to avoid MR, which is not yet strongly evidence-based, is verbal de-escalation (VD).</div><div>This naturalistic observational study included individuals with schizophrenia who were involuntarily transferred from their homes to the emergency room by a specialized psychiatric home care team between 2008 and 2020. In 2013, the entire team began annual training in VD techniques, following Project BETA guidelines. The study compares MR use before and after the introduction of VD training. It also aims to identify the factors associated with the use of MR during these transfers.</div><div>Clinical and sociodemographic characteristics were compared between those who required MR and those who did not. Among 420 transfers included in the study, MR was used in 128 cases (30.5 %), while 292 (69.5 %) were managed without it. After the training, there was a 40 % reduction in MR use.</div><div>A multivariate logistic regression analysis identified three significant factors that were associated with MR use: the use of VD, PANSS-Excited Component (PANSS-EC) score (assessed prior to transfer), and age. A PANSS-EC score ≥20 was strongly associated with MR (OR = 4.36, 95 % CI: 2.74–6.95).</div><div>These findings suggest that staff training in VD may be associated with reduced MR use during involuntary transfer of patients with schizophrenia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 193-199"},"PeriodicalIF":3.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the connections between Gaming Disorder and real-life problems through network analysis","authors":"Halley M. Pontes","doi":"10.1016/j.jpsychires.2025.06.008","DOIUrl":"10.1016/j.jpsychires.2025.06.008","url":null,"abstract":"<div><div>Recent research on Gaming Disorder (GD) has emphasized the important role of experiences related to psychiatric distress and functional impairments in GD, however, little is known about the complex relationship between its symptoms and specific associated problems. The present study recruited a nationally representative sample of 1,074 British adults to investigate the relationship between GD Symptoms and GD Problems within a network analysis framework among gamers. The results of the node centrality analysis revealed that <em>significant distress/impairment</em> was central, exhibiting the highest betweenness, closeness, and strength, and acted as a critical bridge linking other symptoms. Moreover, <em>impaired control</em> was the most influential node in terms of its potential to affect other nodes in the network, implying that both nodes are core symptoms of GD. Additionally, bridge centrality analysis suggested that while <em>significant distress/impairment</em> directly connected GD Symptoms with GD Problems, the nodes related to problems served as gateways between the two identified GD core symptoms, further propagating effects across the network. These findings present important implications as targeted interventions aiming at alleviating the experience of psychiatric distress and functional impairments associated with GD, while improving gaming behavior self-regulation may lead to cascading benefits reducing the overall intensity of symptoms experienced. Interestingly, the findings also supported the notion that GD Problems acted as bridges between the two GD core symptoms identified (i.e., <em>significant distress/impairment</em> and <em>impaired control</em>), signifying that they connect the GD core symptoms, allowing the effects of one symptom to influence the other while intensifying the overall experience of symptomatology.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 211-215"},"PeriodicalIF":3.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabidiol mechanism of action on modulating extinction and reinstatement of methamphetamine-seeking behavior: Targeting D2-like dopamine receptors in the hippocampus","authors":"Seyed Erfan Omidiani ,&nbsp;Mahsa Mohammadi ,&nbsp;Masoud Seddighfar ,&nbsp;Ronak Azizbeigi ,&nbsp;Abbas Haghparast","doi":"10.1016/j.jpsychires.2025.06.011","DOIUrl":"10.1016/j.jpsychires.2025.06.011","url":null,"abstract":"<div><div>Methamphetamine (METH) use disorder is a significant public health problem lacking effective and approved pharmacological treatments. Cannabidiol, a non-addictive compound derived from cannabis, has garnered attention as a potential therapeutic agent. However, the mechanisms underlying its effects on improving drug-related behaviors remain unclear. Multiple lines of evidence suggest that CBD exerts its effects by modulating the mesocorticolimbic dopamine system. D2-like receptors in the CA1 region of the hippocampus play a significant role in relaying memory and emotional signals related to the processing of drug-related cues. Therefore, this study aims to investigate the role of CA1 D2-like receptors in mediating the effects of CBD on METH-seeking behavior during extinction and reinstatement in the conditioned place preference (CPP) model. For this purpose, rats were administered various doses of Sulpiride (0.25,1, or 4 μg/0.5 μl) as a D2-like receptor antagonist before intracerebroventricular (ICV) injection of CBD (10 μg/5 μl) during a 10-day extinction period. Additionally, a separate group of rats received Sulpiride (0.25,1, or 4 μg/0.5 μl) before a single CBD injection (50 μg/5 μl) on the reinstatement day. The findings indicated that Sulpiride (1 and 4 μg) significantly attenuated CBD's acceleration of METH-CPP extinction (p &lt; 0.01 and p &lt; 0.05, respectively). Moreover, Sulpiride (1 and 4 μg) during the reinstatement phase notably reversed CBD's preventive effects on the reinstatement of reward-seeking behavior (p &lt; 0.05 and p &lt; 0.001, respectively). In summary, these results suggest that CBD's ability to shorten the extinction period and suppress METH reinstatement is partially mediated through interactions with D2-like dopamine receptors in the CA1 region of the hippocampus. These findings offering insight into more precise and effective interventions for METH use disorder.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 200-210"},"PeriodicalIF":3.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}