Journal of psychiatric research最新文献

{"title":"Suicide in Italy during the COVID-19 pandemic: Excess mortality in 2021 among men and adolescent girls.","authors":"Enrico Grande, Francesco Grippo, Stefano Marchetti, Luisa Frova","doi":"10.1016/j.jpsychires.2024.11.063","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.063","url":null,"abstract":"<p><p>During the COVID-19 pandemic populations have been exposed to unprecedented and prolonged psychosocial distress that may have adversely affected mental health and suicidal behavior, especially in specific subgroups of the population. This study aims to evaluate possible excess suicide mortality in Italy during 2021 according to sex and age group. Cause-of-death data were used to analyze suicide deaths in the whole resident population in Italy aged ≥10 years. Excess suicide mortality according to sex and age group was evaluated by comparing observed deaths to expected deaths estimated using Poisson regression models fitted to 2011-2019 data, to capture pre-pandemic temporal trends. In Italy, during 2021 overall suicide mortality increased in both sexes, showing a significant excess in the male population compared to expected levels based on the pre-pandemic temporal trend. The number of male suicides was higher than expected in all age groups, with significant excesses for ages 25-34 or 65-84 years. A significantly high excess was found among females aged 10-24 years. Findings suggest monitoring the long-term effect of the COVID-19 pandemic on suicide mortality and targeting interventions on specific age groups of both male and female populations, especially adolescent girls.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"282-285"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intergenerational effects of the Holocaust following the October 7 attack in Israel.","authors":"Amit Shrira, Lee Greenblatt-Kimron, Yuval Palgi","doi":"10.1016/j.jpsychires.2024.11.067","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.067","url":null,"abstract":"<p><p>Descendants of traumatized individuals may exhibit latent vulnerability, meaning they are typically well-functioning yet more vulnerable to stressful and traumatic events. Nevertheless, such vulnerability is not omnipresent, and some descendants are more prone than others to develop posttraumatic disorder (PTSD) and other psychopathologies. Ancestral PTSD was suggested as an aggravating factor for intergenerational effects. The current study examined whether Holocaust descendants (i.e., children and grandchildren of Holocaust survivors) show unique posttraumatic reactions to the October 7 terrorist attack and the ensuing war and whether parental/grandparental PTSD exacerbated these reactions. A web-based random sample of 582 Israeli Jews completed questionnaires a year before the October 7 terrorist attack (Wave 1, 2022) and two months after the attack and into the war (Wave 3, December 2023). Results showed that pre-war probable PTSD rates were similar across the study groups (10.4% and 11.5% among Holocaust descendants and descendants of those not directly exposed to the Holocaust, respectively). In contrast, probable PTSD rates during the war mainly increased among Holocaust descendants (20.9% and 11.5% among Holocaust and comparison descendants, respectively). Higher probable PTSD rates were especially noticeable in Wave 3 among Holocaust descendants who reported that their parents/grandparents had probable PTSD even after controlling Wave 1 probable PTSD, background characteristics, and levels of traumatic exposure. The findings have important implications for understanding the intergenerational effects of trauma as they strongly support the latent vulnerability hypothesis three generations after ancestral trauma, and further suggest that ancestral PTSD plays a major role in aggravating such vulnerability.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"298-303"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and disruptive nocturnal behaviors as short-term predictors of suicidal intent: An ecological momentary assessment study.","authors":"Melanie L Bozzay, Gemma T Wallace, Megan L Rogers","doi":"10.1016/j.jpsychires.2024.11.066","DOIUrl":"10.1016/j.jpsychires.2024.11.066","url":null,"abstract":"<p><strong>Background: </strong>Emerging research suggests that poor sleep quality and some disruptive nocturnal behaviors (DNBs) may be advance markers of short-term worsening in suicidal intent. However, relationships between many types of DNBs and suicide risk have not been examined, and whether DNBs provide useful information apart from sleep quality in predicting suicidal intent is unknown. This study addressed these critical knowledge gaps by examining associations between sleep quality, DNBs, and next-day suicidal intent in a community sample of adults.</p><p><strong>Methods: </strong>A sample of 237 adults with severe suicidal ideation provided daily indices of sleep quality and DNBs, and suicidal intent 6 times per day for 2 weeks via ecological momentary assessment. Linear mixed models and general linear models were conducted to examine relationships between sleep quality and DNBs with measures of average severity of suicidal intent and fluctuations in intent over time.</p><p><strong>Results: </strong>Poor sleep quality and specific DNBs (sleep disruptions due to general nervousness, trauma-related memories and/or nightmares interrupting sleep, and non-trauma-related anxiety or panic) predicted more severe suicidal intent in multivariate models. Only poor sleep quality predicted within-day variability in suicidal intent.</p><p><strong>Conclusions: </strong>These findings suggest that monitoring sleep quality and specific DNBs may be a useful indicator of short-term risk for worsening in suicidal intent.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"304-311"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional regulation as a mediating variable between risk of psychosis and common mental health problems in adolescents.","authors":"Inma Fernández, Óscar Vallina-Fernández, Sandra Alonso-Bada, Mar Rus-Calafell, Mercedes Paino","doi":"10.1016/j.jpsychires.2024.11.058","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.058","url":null,"abstract":"<p><strong>Background: </strong>The main clinical high-risk of psychosis (CHRp) approaches are focused on core features of schizophrenia that might surface in the prodromal phases, mainly psychotic-like experiences (PLEs) (e.g., prodromal or schizotypal symptoms) or associated phenomena like basic symptoms or anomalous experiences of the self. Given that PLEs vary depending on distress levels, related common mental health problems, emotional regulation (ER) strategies and eventual clinical outcomes, exploring the heterogeneous nature of these PLEs and their psychological correlates could aid in distinguishing between subclinical and clinical psychotic experiences. The present study aims firstly to generate new evidence on the understanding of clinical relevance of PLEs and associated phenomena in a non-clinical representative sample of 1824 Spanish adolescents, according to their CHRp level (high/moderate/low). Secondly, we analyzed the possible mediating effect of three different emotional regulation strategies ((experiential avoidance (EA), cognitive reappraisal (CR) and emotional suppression (ES)) between PLEs and non-specific symptoms of depression, anxiety, stress, trauma related distress and substance use. Results showed that a more frequent use of EA and ES resulted in a higher CHRp, with no differences in the use of CR. In addition, EA emerged as a significant mediating factor between CHRp and the development of emotional symptoms and substance use. Emotion regulation strategy may account for heterogeneity in PLE outcomes. The use of EA as a coping strategy for their PLEs in adolescents with CHRp may facilitate the development of common mental health problems such as anxiety, depression or cannabis use pathologies. Helping adolescents at CHRp to use non-avoidant coping strategies may be indicated if their preventive effects are demonstrated.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"273-281"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of xanomeline-trospium chloride in schizophrenia: A systematic review and meta-analysis.","authors":"Artur Menegaz de Almeida, Fernanda Moraes Tamashiro, Maria Eduarda Cavalcanti Souza, Iasmin Isabelli Luiz Silvério, Celso de Almeida Souza Miranda, Ítalo Barros Andrade, Michele Kreuz, Francisco Cezar Aquino de Moraes, Francinny Alves Kelly","doi":"10.1016/j.jpsychires.2024.11.047","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.047","url":null,"abstract":"<p><strong>Introduction: </strong>Schizophrenia is one of the psychiatric illnesses with a higher mortality rate. Xanomeline, an oral muscarinic receptor agonist, combined with Trospium, a pan-muscarinic receptor antagonist, represents a promising new treatment for schizophrenia that has been tested in clinical trials. Herein, we aimed to perform a meta-analysis assessing Xanomeline-Trospium Chloride's (XTC) safety and efficacy for treating schizophrenia.</p><p><strong>Materials and methods: </strong>MEDLINE, EMBASE, and Cochrane databases were searched for randomized clinical trials testing XTC safety and efficacy in patients with schizophrenia on May 03, 2024. The research protocol was registered with the International Prospective Register of Systematic Reviews (CRD42024547487). Data were examined using the Mantel-Haenszel method and 95% CIs. Heterogeneity was assessed using I² statistics. R, version 4.3.2, was used for statistical analysis.</p><p><strong>Results: </strong>3 RCTs and 674 patients were included, of whom 332 (49%) received XTC. The change from baseline in the Positive and Negative Syndrome Scale (PANSS) total score was significantly higher in the XTC arm (MD -13.17; 95% CI -20.16 to -6.18; P = 0.0002; I² = 100%). Treatment with XTC resulted in improvements across all subscales of the PANSS. Additionally, XTC was associated with the occurrence of cholinergic adverse events, including nausea (18,52% vs. 3,79%; RR 4.37; 95% CI 2.43 to 7.84; P < 0.000001; I² = 19%) but was not associated with akathisia (MD -0.00; 95% CI -0.13 to 0.13; P = 0.9; I² = 0%) or body weight gain (MD -0.36; 95% CI -1.18 to 0.46; P = 0.38; I² = 51%).</p><p><strong>Conclusion: </strong>XTC is effective in improving schizophrenia symptoms. However, it is associated with some bothersome AEs that may undermine its tolerability and lead to increased discontinuation rates, despite its efficacy.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"262-272"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Siblings' similarity in neural responses to loss reflects mechanisms of familial transmission for depression.","authors":"Lilian Y Li, Lauren N Grzelak, Randy P Auerbach, Stewart A Shankman","doi":"10.1016/j.jpsychires.2024.11.069","DOIUrl":"10.1016/j.jpsychires.2024.11.069","url":null,"abstract":"<p><p>Having a depressed first-degree relative is one of the most replicated risk factors for depression. Research on the familial transmission of depression, however, has largely ignored siblings, even though sibling relationships are commonplace and characterized by frequent and intense emotions. It has been suggested that frequent contacts in close relationships lead to similarities in emotions and cognitions over time, a process underpinned by biobehavioral synchrony. Consequently, to shed light on the neural mechanism underlying familial transmission of depression, the present study tested whether neural similarity in response to reward and loss, indexed by inter-subject correlation (ISC), was associated with major depressive disorder (MDD) diagnosis, depression symptom severity, and relationship quality in sibling pairs. Same-sex, full-sibling pairs (N = 108 pairs) with a wide range of depression severity separately completed a monetary reward task during electroencephalography acquisition. The ISC in response to reward and loss feedback was calculated using circular correlation between siblings' phase angles in delta and theta frequency bands, respectively. Significant sibling ISC to reward and loss was observed, with activity maximal at frontocentral sites. Loss-related theta, but not reward-related delta, ISC was associated with: (a) greater depression risk (both lifetime MDD diagnosis and self-reported symptom severity), but not anxiety, and (b) worse sibling relationship quality during childhood in each sibling. Findings provide initial evidence that similarities in neural responses to loss may be a result of disturbed childhood sibling relationships, which may specifically increase risk for depression during adulthood.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"286-293"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in regional homogeneity in schizophrenia patients comorbid with metabolic syndrome treated with risperidone or clozapine.","authors":"Xinyue Chen, Xinyan Wu, Wenjing Zhang, Kaike Liao, Rui Yu, Su Lui, Nian Liu","doi":"10.1016/j.jpsychires.2024.11.068","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.068","url":null,"abstract":"<p><p>The neuroimaging mechanisms that arise in patients with schizophrenia and comorbid metabolic syndrome (MetS) remain poorly understood. This study was devised to examine potential alterations in regional homogeneity (ReHo) that arise in schizophrenia patients with comorbid MetS undergoing risperidone or clozapine treatment. In total, 43 schizophrenia patients undergoing risperidone or clozapine treatment were enrolled in this study, of whom 20 had comorbid MetS (SZ-MetS) while 23 did not (SZ-nMetS). In addition, 28 sex- and age-matched healthy controls (HCs) were analyzed. Analyses of covariance (ANCOVA) were used to compare ReHo in this study, utilizing age, sex, and years of education as covariates, with subsequent post hoc testing. Correlations between brain regions showing differences between groups of patients with schizophrenia and MetS-related indicators were also assessed. Relative to HCs, patients in both the SZ-MetS and SZ-nMetS groups exhibited reductions in ReHo in the right postcentral gyrus, left superior parietal gyrus, and left middle occipital gyrus. A decrease in ReHo was also evident in the left calcarine fissure and surrounding cortex and the right angular gyrus of patients in the SZ-MetS group, while the SZ-nMetS group exhibited reductions in ReHo in the left superior occipital gyrus and the right precuneus, together with an increase in ReHo in the right inferior orbitofrontal gyrus. Compared to the SZ-nMetS group, the SZ-MetS group exhibited a reduction in ReHo in the right inferior orbitofrontal gyrus. The ReHo of the right inferior orbitofrontal gyrus was significantly negatively correlated with BMI, waist circumference, and hip circumference in the SZ-MetS and SZ-nMetS groups. A reduction in ReHo in the right inferior orbitofrontal gyrus may thus be related to MetS in schizophrenia patients undergoing treatment. The findings may provide an imaging basis for brain alterations in patients with schizophrenia combined with MetS and provide a new insight into the neuroimaging mechanisms associated with MetS in patients with schizophrenia.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"245-252"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological performances and brain perfusion patterns in patients with first episode psychosis.","authors":"Eleni Douli, Georgios Georgiou, Eleni Konstantinopoulou, Andreas Karampas, Marios Plakoutsis, Chrissa Sioka, Eleni Aretouli, Petros Petrikis","doi":"10.1016/j.jpsychires.2024.11.053","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.053","url":null,"abstract":"<p><p>Abnormalities in cognition are a pronounced feature in primary psychotic disorders and may appear long before the manifestation of the first-episode psychosis (FEP). Although brain functional changes may precede structural alterations, brain perfusion patterns in FEP and most importantly their correlations with cognition remain poorly understood. In the present study we assessed neurocognitive functions and regional cerebral blood flow (rCBF) in 53 patients with a diagnosis of FEP. A special emphasis was placed on the assessment of basic executive functions. Cerebral perfusion patterns were measured by SPECT rCBF scintigraphy in cerebral lobes bilaterally and Brodmann Areas (BAs). Patients showed impairments in long-term verbal memory, processing speed/response latency and executive cognition. Pathological perfusion was prominent in the limbic lobes bilaterally. BAs with the largest hypoperfusion, were the subgenual area (BA25) and hippocampal areas (BA 28 and 36). The left temporal lobe was also hypoperfused, and specifically the inferior temporal gyrus (BA 20), the left middle (BA 21) and superior (BA 22) temporal gyrus, and the temporal pole (BA 38). Hypoperfusion was limited in the frontal regions, although specific BAs displayed pathological perfusion (i.e., BA 24). Cerebral lobe perfusion was not correlated with compromised cognitive abilities.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"237-244"},"PeriodicalIF":3.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American Heart Association's new “Life's Essential 8” score and depression in adults with chronic diseases and comorbidity: NHANES, 2007 through 2018","authors":"Yuan Zhang ,&nbsp;Yanfang Wang ,&nbsp;Xiaoting Fan,&nbsp;Yue He,&nbsp;Runhong Li,&nbsp;Xiaowei Cheng,&nbsp;Lina Jin","doi":"10.1016/j.jpsychires.2024.11.061","DOIUrl":"10.1016/j.jpsychires.2024.11.061","url":null,"abstract":"<div><h3>Objective</h3><div>The coexistence of depression and chronic diseases might lead to greater disability and increased mortality, and the American Heart Association (AHA) recently proposed Life's Essential 8 (LE8) score to quantify cardiovascular health (CVH). The study aimed to examine the association between LE8 and depression among adults with chronic diseases and comorbidity.</div></div><div><h3>Methods</h3><div>14,029 adults with chronic diseases from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018 were included in the study. Overall LE8 and subscale scores were categorized into low, moderate, and high groups. Multivariate logistic regressions were applied to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between LE8 and depression among adults with various chronic diseases and comorbidity.</div></div><div><h3>Results</h3><div>After adjusting for all covariates, compared to low CVH, high CVH was associated with a significantly lower presence of depressive symptoms among adults with diabetes [OR (95% CI), 0.25 (0.11, 0.58)], hypertension [0.27 (0.20, 0.36)], coronary heart disease [0.16 (0.07, 0.36)], stroke [0.29 (0.11, 0.76)], hyperlipidemia [0.24 (0.20, 0.30)], at least one chronic comorbidity [0.25 (0.21, 0.30)], any single chronic condition [0.28 (0.21, 0.38)], and comorbidities [0.27 (0.19, 0.38)]. Similarly, moderate CVH was also associated with a lower presence of depressive symptoms among adults with various chronic diseases and comorbidities. Dose-response relationships were found, revealing that the ORs for depressive symptoms increased with the decrease of the LE8 score and subscale scores among adults with chronic diseases and comorbidities.</div></div><div><h3>Conclusion</h3><div>The prevalence of depression increases with decreasing levels of the LE8 and subscale scores among adults with various chronic diseases and comorbidities in the United States.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 188-196"},"PeriodicalIF":3.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered topology in cortical morphometric similarity network in recurrent major depressive disorder","authors":"Ziyun Xu ,&nbsp;Zhifeng Zhou ,&nbsp;Weiqun Tao ,&nbsp;Wentao Lai ,&nbsp;Long Qian ,&nbsp;Wei Cui ,&nbsp;Bo Peng ,&nbsp;Yingli Zhang ,&nbsp;Gangqiang Hou","doi":"10.1016/j.jpsychires.2024.11.038","DOIUrl":"10.1016/j.jpsychires.2024.11.038","url":null,"abstract":"<div><h3>Background</h3><div>Recurrent major depressive disorder (RDD) is increasingly understood to be associated with a 'disconnection' within the brain areas. But, the true understanding of cortical connectivities remains challenging. Morphometric similarity network (MSN) with multi-modal magnetic resonance imaging (MRI) could provide more information about cortical micro-architecture changes in individuals with RDD.</div></div><div><h3>Methods</h3><div>Here, we integrated multi-modal features from T1-weighted imaging, diffusion tensor imaging (DTI), and inhomogeneous magnetization transfer imaging (ihMT) to construct MSN. We used graph theory to calculate topological changes in MSN and explore their relationship with the severity and recurrence. The topological properties of 42 RDD patients were compared with 56 age, sex, and education-matched healthy controls.</div></div><div><h3>Results</h3><div>RDD subjects showed significantly decreased global efficiency, increased characteristic path length, reduced nodal efficiencies in the parietal lobe, subcortical area, and temporal lobe, increased betweenness centrality in the left supplementary motor area (SMA), decreased intra-modular connections in the parietal module and decreased inter-modular connections between the parietal and prefrontal modules. Notably, the global efficiency, characteristic path length, local efficiency of the right superior parietal gyrus, and inter-modular connections between the parietal and prefrontal modules were significantly associated with the number of depressive episodes. The betweenness centrality in SMA and the intra-modular connections in the parietal module showed a positive relationship with 17-item Hamilton Rating Scale for Depression (HAMD) scores.</div></div><div><h3>Conclusions</h3><div>The altered topology of MSN may serve as potential underlying pathological mechanisms of RDD. The impaired information integration of the network, particularly the disconnection within the fronto-parietal network, may be associated with the recurrence of depression. The SMA and the fronto-parietal network may be related to the severity of depression.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 206-213"},"PeriodicalIF":3.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}