Journal of psychiatric research最新文献

{"title":"Long-COVID-19 and Cognition: Persistent attention deficits after hospital discharge","authors":"Aureo do Carmo Filho , Max Kopti Fakoury , Guilherme Janeiro Schmidt , Ana Lucia Taboada Gjorup , André Casarsa Marques , Júlio Cesar Tolentino Junior , Juliana Janeiro Schmidt , Andreza Maia , Eelco van Duinkerken , Kai-Uwe Lewandrowski , Kenneth Blum , Sergio Luis Schmidt","doi":"10.1016/j.jpsychires.2025.06.009","DOIUrl":"10.1016/j.jpsychires.2025.06.009","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 277-279"},"PeriodicalIF":3.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of methylphenidate exposure on glutamate and glutamate-related metabolites in patients with ADHD: a systematic review","authors":"Tobias Richards ,&nbsp;Hugo A. E. Morandini ,&nbsp;Pradeep Rao","doi":"10.1016/j.jpsychires.2025.06.004","DOIUrl":"10.1016/j.jpsychires.2025.06.004","url":null,"abstract":"<div><h3>Background</h3><div>Dysfunctional glutamatergic neurotransmission has been implicated in the underlying pathogenesis of Attention Deficit Hyperactivity Disorder (ADHD). The psychostimulant methylphenidate (MPH), which is used as a first line treatment for ADHD, has been shown to have both acute and chronic effects on prefrontal cortex glutamatergic afferents. Animal studies have also identified an effect of MPH and glutamate in prefrontal areas. Despite this there are ongoing questions as to the extent and direction of this effect, as well as its impact on other neurobiological processes.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted following the PRISMA guidelines through the databases Embase, ScienceDirect and PubMed. Studies following pre/post and prospective designs were reviewed. Brain regions, metabolites of interest and phenotypical information were extracted from the relevant studies. Quality assessment tools of the National Heart, Lung, and Blood Institute were used to evaluate the risk of bias.</div></div><div><h3>Results</h3><div>There were 10 studies that met criteria for inclusion. Three studies in children with ADHD identified a statistically significant decrease in glutamate level within fronto-cerebellar circuit and amygdala after MPH treatment. Most studies investigating adults with ADHD did not show a significant change in glutamate and glutamate-related metabolites after MPH exposure.</div></div><div><h3>Conclusion</h3><div>A trend for decreased glutamate levels after MPH exposure were observed in studies involving children with ADHD. Future studies investigating the effects of MPH in children and adults with ADHD should utilise higher magnet field strength with larger sample sizes and over a longer duration of time with blinding and control group research design.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 236-243"},"PeriodicalIF":3.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Odor memory, but not odor identification, is impaired in children with attention-deficit/hyperactivity disorder","authors":"Fei Peng ,&nbsp;Shaowei Li ,&nbsp;Linxun Ye ,&nbsp;Meimin Han ,&nbsp;Qianwen Ma ,&nbsp;Wanling Zhang ,&nbsp;Lixin Chen ,&nbsp;Ying Li ,&nbsp;Laiquan Zou","doi":"10.1016/j.jpsychires.2025.06.007","DOIUrl":"10.1016/j.jpsychires.2025.06.007","url":null,"abstract":"<div><div>Attention-deficit/hyperactivity disorder (ADHD) is one of the most common, highly inheritable childhood-onset psychiatric disorders. Previous research indicated that individuals with ADHD may experience altered olfactory function, but the results were inconsistent. The present study compared odor identification and odor memory abilities between 51 children with ADHD and 51 healthy controls. Odor identification ability was assessed using the U-Sniff test, and odor memory ability was evaluated using a modified version of the U-Sniff test. The ANCOVA results showed no significant difference in odor identification. However, children with ADHD had significantly lower hit rates in odor memory, with no differences in false alarm rates or hits-false alarms. We found a significant correlation between the hit rate in odor memory and the scores on the Children's ADHD Behavior Rating Scale, the Swanson, Nolan, and Pelham-IV Rating Scale (SNAP-IV), the Inattention subscale of the SNAP-IV and the Hyperactivity Index of the Conners Parent Symptom Questionnaire. These findings indicate that olfactory memory might be impaired in children with ADHD, providing a potential behavioral marker for assessing the impact of the disorder on cognitive functions.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 157-162"},"PeriodicalIF":3.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative analysis of psychosocial, chronotype, and environmental predictors of aggressive behavior in Adolescents: Insights from machine learning","authors":"Tam Nguyen-Louie ,&nbsp;Michael J. McCarthy ,&nbsp;Emil F. Coccaro ,&nbsp;Alejandro D. Meruelo","doi":"10.1016/j.jpsychires.2025.06.005","DOIUrl":"10.1016/j.jpsychires.2025.06.005","url":null,"abstract":"<div><div>Aggressive behavior in adolescents and young adults is a significant public health concern associated with adverse educational, social, and mental health outcomes. This study aimed to identify key predictors of aggression using a cross-sectional dataset from a large, longitudinal U.S. cohort. The outcome was self-reported aggressive behavior, and predictors spanned demographic, psychosocial, behavioral, and contextual domains, including adverse life events, impulsivity, family conflict, peer and school environments, and chronotype.Multiple models were evaluated, including linear regression, a hypertuned random forest, a tuned gradient boosting machine (GBM), XGBoost, and an ensemble model combining random forest and GBM predictions. All models were trained using five-fold cross-validation across five multiply imputed datasets. Linear regression achieved the highest predictive accuracy (r = 0.313; MSE = 40.76), followed closely by the random forest (r = 0.311; MSE = 40.71). The ensemble and GBM models showed slightly lower performance. Across models, key predictors included adverse life events, delayed chronotype, peer network health, family cohesion, and normalized household income.These findings underscore the contribution of environmental and psychological stressors to adolescent aggression, particularly the buffering role of cohesive peer and family relationships. Despite similar predictive accuracy across models, machine learning methods offered advantages for variable importance ranking and interaction discovery. Results highlight the utility of integrating diverse psychosocial, behavioral, and contextual measures to better understand complex behavioral outcomes and inform targeted prevention strategies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 91-103"},"PeriodicalIF":3.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring emotion regulation in PTSD with Insomnia: A task-based fMRI study","authors":"Yuyi Zhang ,&nbsp;Yunxiao Guo ,&nbsp;Xiaoqin Wang ,&nbsp;Yinong Liu ,&nbsp;Sijun Liu ,&nbsp;Junrong Zhao ,&nbsp;Lianzhong Liu ,&nbsp;Ping Yu ,&nbsp;Zhihong Ren","doi":"10.1016/j.jpsychires.2025.06.002","DOIUrl":"10.1016/j.jpsychires.2025.06.002","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbances and difficulties in emotion regulation are core symptoms of post-traumatic stress disorder (PTSD) and are closely related. However, the neural mechanisms underlying this relationship remain underexplored. To address this gap, we used task-based functional magnetic resonance imaging (fMRI) to examine brain mechanisms related to emotional processing and regulation in PTSD patients with and without insomnia.</div></div><div><h3>Methods</h3><div>Forty-six PTSD patients (23 with insomnia, 23 without insomnia) and 28 controls reported clinical symptoms (including PTSD, insomnia, and anxiety/depression) and completed the Shifted Attention Emotion Appraisal Task (SEAT) during fMRI. We compared the neural differences in implicit emotion regulation-related regions between PTSD patients with and without insomnia based on both whole-brain and ROI analyses.</div></div><div><h3>Results</h3><div>Compared to PTSD patients without insomnia, those with comorbid insomnia exhibited significant deactivation in the left dorsolateral prefrontal cortex (BA46) and the left inferior frontal gyrus (triangular part, BA47) during implicit emotion processing. Additionally, during appraisal-based implicit emotion regulation, the left inferior temporal gyrus (BA37) showed significant deactivation. Furthermore, in the PTSD-insomnia group, insomnia severity was significantly correlated with activation in the left fusiform gyrus (BA37).</div></div><div><h3>Conclusions</h3><div>These findings highlight potential neural mechanisms underlying the differences between PTSD patients with and without insomnia. The observed alterations in these regions may serve as neural biomarkers for PTSD with comorbid insomnia and could be potential targets for developing novel therapeutic interventions.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 125-137"},"PeriodicalIF":3.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural activities of theory of mind in individuals with schizophrenia: A meta-analysis of fMRI studies","authors":"Pei Xie ,&nbsp;ChaoZheng Huang ,&nbsp;QingQing Li ,&nbsp;HanBin Sang","doi":"10.1016/j.jpsychires.2025.05.080","DOIUrl":"10.1016/j.jpsychires.2025.05.080","url":null,"abstract":"<div><div>Neuroimaging evidence regarding the activation of brain regions associated with the Theory of Mind (ToM) in individuals with schizophrenia remains inconsistent. Some studies identified decreased activation in various regions, such as the insula, frontal gyrus, superior temporal gyrus, and precuneus, during ToM tasks in schizophrenia compared with healthy people; others reported increased activation in these areas. Additionally, neural activity of individuals with schizophrenia compared with individuals at risk of schizophrenia has not been uniformly demonstrated. This study selected 44 studies that employed functional magnetic resonance imaging (fMRI) technology to explore ToM in individuals with schizophrenia, healthy controls, and at-risk for schizophrenia groups, adopted an Activation Likelihood Estimation (ALE) meta-analysis to calculate the brain activation regions in the three groups, and further analyzed their differences. Results revealed deficiencies in activation within the mentalization network and mirror neuron system related to ToM processes in individuals with schizophrenia. However, stronger convergent activation in the right middle temporal and superior temporal gyrus indicated compensatory activity in these processes. We also observed stronger convergent activation in the left precuneus and frontal gyrus in individuals at risk of schizophrenia during the ToM processes. This indicated that at-risk individuals also had compensatory activity in ToM processes. These findings shed light on the neural activity characteristics of ToM in individuals with and at risk of schizophrenia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 138-147"},"PeriodicalIF":3.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of behavioral control and impulsivity in first-episode schizophrenia: A MEG-Based beta oscillation analysis","authors":"Yinglin Han ,&nbsp;Linglin Hua ,&nbsp;Yi Xia ,&nbsp;Hao Sun ,&nbsp;JunLing Sheng ,&nbsp;Zhongpeng Dai ,&nbsp;Zhijian Yao ,&nbsp;Qing Lu","doi":"10.1016/j.jpsychires.2025.05.079","DOIUrl":"10.1016/j.jpsychires.2025.05.079","url":null,"abstract":"<div><h3>Background</h3><div>Impaired behavioral control and heightened impulsivity are core neurocogntive deficits in schizophrenia. However, the underlying neural mechanisms remain poorly understood. Studying individuals at inherited risk for schizophrenia may reveal potential endophenotypes, aiding early biomarker identification. Magnetoencephalography (MEG) provides high temporal to investigate inhibitory control deficits at the neurophysiological level. This study hypothesized that patients with first-episode schizophrenia (FES) and their first-degree relatives (FDR) would exhibit altered beta-band oscillatory activity and discrupted functional connectivity during behavioral control tasks, reflecting distinct neural signatures of impaired inhibitory control impairment and impulsivity.</div></div><div><h3>Methods</h3><div>Our study comprised 20 patients with FES, 20 FDR, and 22 matched healthy controls (HCs) to perform a Go/NoGo task during MEG scanning. Beta-band oscillatory activity and functional connectivity (FC) were analyzed in key behavioral control regions, particularly the pre-supplementary motor area (pre-SMA) and left motor cortex (lM1). A machine learning classifier was applied to assess the discriminative power of these neurophysiological features.</div></div><div><h3>Results</h3><div>Compared to HCs, FES participants exhibited significant reduced beta power in both pre-SMA and lM1 (<em>P</em> &lt; 0.005), along with increased beta-band connectivity between these regions during the late-stage of inhibition (<em>P</em> = 0.013). FDR sho<u>w</u>ed intermediate beta power reductions and FC increases, suggesting a potential inherited liability. BIS-11 impulsivity scores were significantly correlated with beta power in both regions (<em>P</em> &lt; 0.01). A classification model integrating neural and behavioral features achieved an original accuracy of 88.7 % and a cross-validated accuracy of 72.6 %, with the highest classification performance observed in the FES group (95 %).</div></div><div><h3>Conclusions</h3><div>These findings highlight beta-band oscillations and pre-SMA-lM1 connectivity as potential neurophysiological markers of behavioral control deficits in schizophrenia. These results provide novel insights into the neural mechanisms underlying impulsivity in schizophrenia and highlight the potential utility of beta-band dynamics as biomarkers for early detection and intervention.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 104-115"},"PeriodicalIF":3.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic anger in a national Sample: Demographic and clinical correlates","authors":"Tapan A. Patel ,&nbsp;Matthew C. Sala ,&nbsp;Kirsten H. Dillon ,&nbsp;Jesse R. Cougle","doi":"10.1016/j.jpsychires.2025.06.006","DOIUrl":"10.1016/j.jpsychires.2025.06.006","url":null,"abstract":"<div><div>Posttraumatic stress disorder (PTSD) is often characterized by intense anger and other negative emotions. This led to the inclusion of the experience of these negative emotions among DSM-5 PTSD diagnostic criteria. Though anger has been linked to a range of different conditions, the concept of posttraumatic anger has not been studied extensively. The present study investigated sociodemographic and psychiatric correlates of posttraumatic anger in a nationally representative sample of individuals exposed to trauma (<em>N</em> = 23,936). Notably, 22.4 % of the sample endorsed posttraumatic anger, and of those that met criteria for PTSD (<em>n</em> = 2339), 80.6 % endorsed posttraumatic anger. We found that female sex, Native American/Alaskan race, and identifying as a sexual minority were associated with increased odds of endorsing posttraumatic anger. Conversely, Asian race, being married, having higher income and education, and being older were associated with lower likelihood of posttraumatic anger. We also found multiple anxiety, mood, and substance used disorders were associated with posttraumatic anger, even after accounting for PTSD. The present study provides novel data on the prevalence of posttraumatic anger and its relevance to specific demographic characteristics and psychiatric disorders.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 50-55"},"PeriodicalIF":3.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between aggression and suicidal behaviors in veterans at risk for suicide","authors":"Alison Krauss ,&nbsp;Michael S. McCloskey ,&nbsp;A. Solomon Kurz ,&nbsp;Mark A. Ilgen ,&nbsp;Suzannah K. Creech ,&nbsp;Marianne Goodman","doi":"10.1016/j.jpsychires.2025.06.001","DOIUrl":"10.1016/j.jpsychires.2025.06.001","url":null,"abstract":"<div><div>Suicide is a leading cause of death among United States veterans. Although aggression is common among veterans and represents a strong predictor of suicidal behaviors in civilians, it is seldom studied among veterans. The scant existing research on aggression and suicide in veterans is limited by its restricted examination of the full range of suicidal behavior, oversimplification of suicide attempt history (no attempt vs. attempt), and its focus on physical aggression rather than examining both physical and verbal aggression as unique correlates of suicide. The current study addresses these gaps in a sample of veterans at high-risk for suicide. Participants (<em>N</em> = 207) were recruited as part of a larger clinical trial examining a suicide intervention; the current study uses the baseline data. Veterans completed a self-report measure of physical and verbal aggression and a clinician-administered interview of suicidal behaviors. Logistic regression models indicated that aggression was unrelated to the presence of suicide attempts or behaviors in this high-risk sample. However, count models suggested that physical and verbal aggression were related to a greater number of suicide attempts, and physical aggression was related to a greater number of suicidal behaviors. The current findings align with civilian research suggesting aggression is a risk factor for frequent suicide attempts. Further research is needed to better understand this association, particularly in determining whether aggression plays a causal role in suicide behaviors in veterans.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 71-75"},"PeriodicalIF":3.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between population density and suicide: a systematic review and meta-analysis","authors":"Chiara Davico ,&nbsp;Marilia Barbosa De Matos ,&nbsp;Marta Borgogno ,&nbsp;Federica Agagliati ,&nbsp;Federica Ricci ,&nbsp;Federico Amianto ,&nbsp;Daniele Marcotulli ,&nbsp;Benedetto Vitiello","doi":"10.1016/j.jpsychires.2025.06.003","DOIUrl":"10.1016/j.jpsychires.2025.06.003","url":null,"abstract":"<div><h3>Background</h3><div>Higher rates of suicide have been reported in rural areas in some countries suggesting that low population density may be associated with a higher risk of suicide. We examined the relationship between population density and suicide rates across different countries worldwide, and evaluated possible moderating effects by sex and age.</div></div><div><h3>Methods</h3><div>A systematic review was conducted by searching the PubMed, Embase and PsychINFO databases for relevant publications following a pre-registered protocol and standard PRISMA methods. A meta-analysis was conducted with the available data.</div></div><div><h3>Results</h3><div>From the 10,916 original non-duplicate articles initially identified, 80, published between 1932 and 2023 and covering time-periods ranging from 1890 to 2019 met the selection criteria. Of them, 83.8 % indicated that lower levels of population density were associated with higher suicide rates. A meta-analysis, based on the data from 8 publications, confirmed a statistically significant association between higher suicide rate and lower population density (OR = 1.87; 95 % CI: 1.53–2.30, z = 6.05, p &lt; 0.001). This association was observed in males (p = 0.009), but not in females (p = 0.091). No consistent age or time effects were found. Context-specific differences in suicide methods were identified.</div></div><div><h3>Conclusions</h3><div>Across diverse socio-economic and cultural settings in the world, living in less densely populated areas involves a higher risk of suicide in the male population. Men are more sensitive to the suicide risk factors associated with less populated areas and should be a target of preventive interventions.</div></div><div><h3>Prospero registration number</h3><div>CRD42022345279.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 116-124"},"PeriodicalIF":3.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}