Journal of psychiatric research最新文献

{"title":"The co-occurrence of depression and dissociation: The relevance of childhood trauma","authors":"Hong Wang Fung ,&nbsp;Grace Wing Ka Ho ,&nbsp;Stanley Kam Ki Lam ,&nbsp;Anson Kai Chun Chau ,&nbsp;Vedat Şar ,&nbsp;Colin A. Ross ,&nbsp;Kunhua Lee ,&nbsp;Wai Tong Chien ,&nbsp;Janet Yuen-Ha Wong","doi":"10.1016/j.jpsychires.2025.02.026","DOIUrl":"10.1016/j.jpsychires.2025.02.026","url":null,"abstract":"<div><div>Recent studies showed that dissociation may be common and persistent in people with depression. Dissociation also predicts subsequent depressive symptoms. Both conditions have been linked with trauma exposure. Yet, little is known about the co-occurrence of depression and dissociation. This multi-sample study investigated the co-occurrence of depressive and dissociative symptoms and its relationship with different types of childhood trauma. We analyzed available data from five samples of Chinese adults (N = 2737 in total). Participants completed the same set of measures of depressive and dissociative symptoms and childhood betrayal and non-betrayal trauma. Across samples, between 22.0% and 50.6% of participants with depression exhibited co-occurring dissociation; the majority of participants with dissociation (67.0%–90.2%) presented with depression too. One-way ANCOVA showed that participants who presented with both depression and dissociation reported a statistically significantly higher number of childhood betrayal and non-betrayal trauma types compared to those who had only one or none of these conditions. Exploratory mediation analysis also revealed that dissociative symptoms partly mediated the relationship between childhood trauma and depressive symptoms, regardless of the type of trauma. Findings suggest that the co-occurrence of depressive and dissociative symptoms is associated with childhood trauma. Individuals who report depressive symptoms or seek treatments for a depressive disorder should be screened for dissociation. Further studies on the reliability, validity, clinical features, and intervention needs of the possible dissociative subtype of depression are required.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 157-163"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual abuse history and psychotropic use characteristics of inpatient children and adolescents with major depressive disorders","authors":"Selma Tural Hesapçıoğlu ,&nbsp;Merve Okuyucu ,&nbsp;Şebnem Büşra Altunkalem Uslu ,&nbsp;Cafer Doğan Hacıosmanoğlu ,&nbsp;Mehmet Fatih Ceylan","doi":"10.1016/j.jpsychires.2025.02.020","DOIUrl":"10.1016/j.jpsychires.2025.02.020","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the clinical and psychopharmacologic characteristics of child and adolescent inpatients diagnosed with major depressive disorder (MDD), with and without a history of sexual abuse.</div></div><div><h3>Methods</h3><div>The 337 consecutive patients who were followed up in a University Child and Adolescent Psychiatry inpatient clinic between 2017 and 2019 were evaluated, and 149 were diagnosed with MDD. MDD diagnosed children and adolescents were divided into two groups based on whether they had a history of sexual abuse (n = 44; Group 1) or did not (n = 105; Group 2).</div></div><div><h3>Results</h3><div>The mean age of group 1 was 14.6 ± 1.6 years (range: 6–18) and group 2 was 14.6 ± 2.2 years (range: 6–18). Group 1 had a significantly higher prevalence of psychiatric comorbidities (p = 0.002), non-suicidal self-injury (p = 0.018), domestic violence (p = 0.008), physical (p = 0.008) and emotional abuse history (p = 0.007), and a longer duration of hospitalization (p &lt; 0.0001). Antipsychotic combination therapy (χ² = 10.772; p = 0.005) and total chlorpromazine equivalent doses were also higher in the sexually abused group (Z = −2.749; p = 0.006).</div></div><div><h3>Conclusion</h3><div>These findings suggest that depressive symptoms in sexually abused children and adolescents may be more resistant to psychopharmacological treatment. Further studies are needed to determine whether these differences are attributable to the neurochemical and neuroanatomical effects of trauma or psychiatric comorbidities.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 189-196"},"PeriodicalIF":3.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esketamine reduces the risk of postpartum depression in women undergoing cesarean section: A systematic review and meta-analysis","authors":"Lőrinc Frivaldszky ,&nbsp;Kincső Lőrincz ,&nbsp;Jakub Hoferica ,&nbsp;Péter Hegyi ,&nbsp;Nándor Ács ,&nbsp;Zsolt Melczer ,&nbsp;Péter Fehérvári ,&nbsp;Márton Keszthelyi","doi":"10.1016/j.jpsychires.2025.02.021","DOIUrl":"10.1016/j.jpsychires.2025.02.021","url":null,"abstract":"<div><h3>Background</h3><div>Postpartum depression (PPD) is a prevalent and debilitating disorder that occurs in 14% of women after giving birth.</div></div><div><h3>Objectives</h3><div>We aimed to assess the efficacy and safety of perioperative esketamine for preventing PPD in women undergoing cesarean section.</div></div><div><h3>Search strategy</h3><div>We performed a systematic literature search in five medical databases - MEDLINE, Cochrane Library, Embase, Scopus, and Web of Science on the 12th of January 2025.</div></div><div><h3>Selection criteria</h3><div>We searched for trials on the efficacy and safety of esketamine for preventing PPD.</div></div><div><h3>Data collection and analysis</h3><div>We collected data on rates of PPD, Edinburgh Postnatal Depression Scale (EPDS) scores, and adverse effects. Pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CI) were calculated using a random-effects model.</div></div><div><h3>Results</h3><div>Our systematic search provided 2681 records; we screened 1336 duplicate-free records. A total of 17 eligible studies were identified after title, abstract, and full-text selection. Esketamine administration was associated with a lower rate of PPD at postpartum days 3–7 and 28–42 (OR = 0.43; 95% CI: 0.31–0.59 and OR = 0.59; 95% CI: 0.39–0.87, respectively). Esketamine administration was associated with significantly lower EPDS scores at postpartum days 3–7 (MD = −1.32; 95% CI: 1.84 to −0.80).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that perioperative administration of esketamine was associated with lower PPD rates and lower scores on the EPDS questionnaire and was considered safe compared to placebo/standard care.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 164-173"},"PeriodicalIF":3.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in clozapine prescription: Results from an Italian 30-year health records registry.","authors":"Maria Ferrara, Ilaria Domenicano, Adriano Bellagamba, Giulia Zaffarami, Lorenzo Benini, Cristina Sorio, Elisabetta Gentili, Vinod H Srihari, Luigi Grassi","doi":"10.1016/j.jpsychires.2025.02.019","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.02.019","url":null,"abstract":"<p><strong>Background: </strong>Clozapine is the only approved medication for treatment-resistant schizophrenia which is equally prevalent on male and female patients. However, studies showed that clozapine is less frequently prescribed to women compared to men.</p><p><strong>Aims: </strong>This study aims to investigate the role of sex in clozapine prescription, taking into account potential sociodemographic and clinical confounding factors.</p><p><strong>Methods: </strong>Patients aged 18-65, with a diagnosis of schizophrenia spectrum disorders were selected from the 46,222 individuals who had access to outpatient psychiatric services of Ferrara, Italy, from 1991 to 2021. Sociodemographic and clinical information including clozapine prescription timing and dosage were analyzed.</p><p><strong>Results: </strong>Among 3901 patients with a schizophrenia spectrum disorders, those who had been prescribed clozapine (189, 4.8%) were significantly more likely to be male (57%), younger at admission to care (30 vs 39.7 years old) and with a schizophrenia diagnosis (77% vs. 49%) compared to those without clozapine prescription. Within patients with a diagnosis of schizophrenia (n = 145), women (n = 60, 41%), compared to men, experienced twice the delay to be prescribed clozapine, both from the prescription of the first antipsychotic to clozapine (mean 1265.7 vs 746.6 days in men, p = 0.03) and from the prescription of the third antipsychotic to clozapine (mean 1214.5 vs 725.8 days in men, p = 0.03). Also, within those diagnosed with schizophrenia, women with a diagnosis of schizophrenia were less likely than men to be prescribed clozapine after the first and third antipsychotic considering both crude (HR = 0.66, p = 0.07; HR = 0.53, p = 0.025) and adjusted hazard ratios (HR = 0.65, p = 0.07; HR = 0.51, p = 0.021).</p><p><strong>Conclusions: </strong>This study showed disparities based on sex in both the use and timing of clozapine, which disadvantages women diagnosed with schizophrenia. Further interventions are needed to increase awareness of possible sex-based barriers to clozapine use in clinical practice, measurement of sources of gender specific bias, and quality improvement initiatives to continuously address challenges in providing adequate treatment to this vulnerable population.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network analysis of obsessive-compulsive symptoms and their comorbidity with other disorders","authors":"Vlasios Brakoulias ,&nbsp;James Elhindi ,&nbsp;Vladan Starcevic","doi":"10.1016/j.jpsychires.2025.02.010","DOIUrl":"10.1016/j.jpsychires.2025.02.010","url":null,"abstract":"<div><h3>Objectives</h3><div>To improve our understanding of the heterogeneity of obsessive-compulsive disorder (OCD) and its comorbidity with other disorders by using network analysis.</div></div><div><h3>Methods</h3><div>An existing data base of 257 participants with a primary diagnosis of OCD and whose symptoms were evaluated using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was subjected to network analysis.</div></div><div><h3>Results</h3><div>The analysis revealed eight clusters of characteristics. Two clusters were too small in numbers to reach any meaningful conclusion. The other six clusters included patients with: 1) contamination and cleaning symptoms with little comorbidity; 2) high prevalence checking symptoms with comorbid depression and anxiety disorders; 3) high prevalence contamination and cleaning symptoms with aggressive obsessions and checking compulsions; 4) high prevalence hoarding symptoms with comorbid depression and anxiety; 5) high prevalence impulsive aggressive, sexual and checking symptoms, hair-pulling and comorbid body dysmorphic disorder; and 6) high prevalence hoarding with impulsive aggressive and checking symptoms with comorbid alcohol use disorder and psychosis.</div></div><div><h3>Conclusions</h3><div>This study highlights the potential role of comorbidity. Contamination/cleaning symptoms were observed to have less psychiatric comorbidity. Symmetry/ordering symptoms did not feature prominently in the symptom clusters, whilst checking compulsions were common to multiple clusters.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 150-156"},"PeriodicalIF":3.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Converging paths: Autistic traits, body image concerns, and disordered eating symptoms in women","authors":"Nora M. Laskowski ,&nbsp;Vanessa C. Jürgensen ,&nbsp;Martin S. Lehe ,&nbsp;Georg Halbeisen ,&nbsp;Georgios Paslakis","doi":"10.1016/j.jpsychires.2025.02.018","DOIUrl":"10.1016/j.jpsychires.2025.02.018","url":null,"abstract":"<div><div>Autistic traits, such as sensory sensitivities and rigid routines, have been linked to body dissatisfaction (BD) and eating disorders (EDs). However, the interplay between autistic traits, fat- and muscularity-related BD, and disordered eating remains underexplored.</div><div>This cross-sectional study examined the relationships between autistic traits, BD, and disordered eating in 298 women. Correlations and mediation analyses, alongside bootstrapping techniques, were used to evaluate relationships between variables.</div><div>Autistic traits were positively associated with “traditional” disordered eating symptoms including food avoidance and selective eating as well as appearance-related aspects of muscle dysmorphia. Autistic traits were positively associated with avoidant-restrictive food intake disorder (ARFID) symptoms. BD was elevated with increasing autistic traits, only in relation to body fat, not muscularity. Only body fat-related BD (BD-F), but not muscularity-related BD (BD-M) mediated the effect of autistic traits on disordered eating symptoms, predicting increases in both ED and body dysmorphic symptoms, as well as reductions in ARFID symptoms.</div><div>Our findings suggest that women with autistic traits may be more susceptible to internalizing socially perpetuated body ideals or to social feedback towards their appearance, as only stereotypically “female-typed” BD-F, but not “male-typed” dissatisfaction with muscularity (BD-M) mediated the link between autistic traits and disordered eating. Implications are discussed.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 204-211"},"PeriodicalIF":3.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends of antipsychotic utilization patterns in 62,607 patients with schizophrenia-spectrum disorders in Hong Kong: An 11-year population-based study with joinpoint regression analysis","authors":"Catherine Zhiqian Fang ,&nbsp;Nicole Lau ,&nbsp;Joe Kwun Nam Chan ,&nbsp;Corine Sau Man Wong ,&nbsp;Wing Chung Chang","doi":"10.1016/j.jpsychires.2025.02.017","DOIUrl":"10.1016/j.jpsychires.2025.02.017","url":null,"abstract":"<div><div>Antipsychotics are the mainstay treatment for schizophrenia-spectrum disorders (SSD). Existing data on real-world antipsychotic utilization patterns were primarily derived from Western countries and disregarded specific psychiatric diagnosis. There is limited research in Asia in this respect. This population-based study identified 62,607 patients aged ≥18-years with an SSD diagnosis who redeemed at least one antipsychotic prescription within 2006–2016, using data from health-record database of Hong-Kong public healthcare-services. We calculated annual prescription rates (per 1000 persons) for any antipsychotic, antipsychotic drug-classes (first- or second-generation-antipsychotics, FGAs or SGAs), formulations (oral or long-acting injectable, LAI), and individual antipsychotics. Joinpoint-regression analyses were performed to assess temporal antipsychotic prescription trends, quantified by average-annual-percent-change (AAPC), with 95% confidence-intervals (CIs). Result showed that overall antipsychotic prescription rate declined over time from 84.7% in 2006 to 79.9% in 2016. Oral-SGA use gradually surpassed oral-FGA use, rising from 23.8% in 2006 to 54.1% in 2016. LAI-use was relatively low in prevalence and significantly, albeit modestly, dropped from 23.7% to 18.8% over 11 years (AAPC: −2.20[-2.50 to −1.09]), but LAI-SGA use raised over time (APPC: 12.96 [6.59–19.70]), mainly driven by paliperidone-LAI. Risperidone and olanzapine represented two most frequently-prescribed oral-SGAs, while clozapine prescription rate was generally low (4.3%–6.1%), but showed significant upward trend (AAPC: 3.36[2.95–3.78]) over the study period. Our results affirm significant rising trend of SGA prescription over time. Yet, clozapine and LAIs remained relatively underutilized, indicating discrepancies between clinical-treatment recommendations and real-world prescribing practices. Further investigation is needed to clarify barriers to guideline-concordant practices to optimize treatment outcome.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 144-149"},"PeriodicalIF":3.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of age on the response to serotonergic and noradrenergic antidepressants: A systematic review, meta-regression and individual participant data pooled analysis","authors":"Paolo Ossola ,&nbsp;Maria Lidia Gerra ,&nbsp;Lorenzo Luviè ,&nbsp;Antonio Piacente ,&nbsp;Carlo Marchesi ,&nbsp;Georgios Schoretsanitis ,&nbsp;Jonathan W. Stewart","doi":"10.1016/j.jpsychires.2025.02.013","DOIUrl":"10.1016/j.jpsychires.2025.02.013","url":null,"abstract":"<div><div>It is known that the serotonin and norepinephrine systems change with age. Consequently, response to antidepressants having different effects on these two systems may vary between patients of different ages.</div><div>We systematically searched Embase/Medline/PsychINFO until December 2024 for randomised controlled trials (RCT) in patients with unipolar major depressive disorder comparing response rates to serotonergic versus noradrenergic antidepressants (PROSPERO pre-registration #CRD42020145386). Our primary outcome was to assess the effect of age on response rates to serotonergic versus noradrenergic antidepressants in unipolar depression. We then performed a pooled analysis of individual participant data (IPD).</div><div>Seventy-four RCTs with a total of 8981 participants (4488 with serotonergic and 4493 with noradrenergic antidepressants) were included in the meta-analysis. We found no differences in the response rates to the two antidepressants, although the improvement in depressive symptoms was greater in the noradrenergic arm (subset of n = 31 studies, z = −2.61; p = 0.009); younger age was associated with a greater response to serotonergic than noradrenergic agents both in terms of response rates (estimate = −0.011; p-value = 0.041) and symptom improvement (estimate = −0.016; p-value&lt;0.0001), even after controlling for year of publication, study design, baseline severity, type of noradrenergic medication, inpatients, and dropout rates. The effect of age on antidepressant response was also confirmed in the IPD pooled analysis (n = 339), in which responders to serotonergic antidepressants were significantly younger than non-responders (p-value = 0.028) and than responders to noradrenergic antidepressants (p-value = 0.034).</div><div>Our study highlights the importance of age when considering the efficacy of serotonergic versus noradrenergic antidepressants as part of a precision psychiatry-oriented approach.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 133-143"},"PeriodicalIF":3.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neuroinflammatory effects of Nociceptin/Orphanin FQ receptor activation can be related to depressive-like behavior","authors":"Alice Barros Câmara ,&nbsp;Igor Augusto Brandão","doi":"10.1016/j.jpsychires.2025.02.012","DOIUrl":"10.1016/j.jpsychires.2025.02.012","url":null,"abstract":"<div><div>There is limited information on the role of the Nociceptin/Orphanin FQ receptor (NOPR) in neuroinflammation, and there is growing interest in the participation of the NOPR in depression etiology. This study aims to evaluate the neuroinflammatory effects of the NOPR activation in mice submitted to social defeat protocol (SDP). Firstly, male Swiss mice were submitted to the social defeat protocol during 10 or 20 days and treated with the NOPR agonist Ro 65–6570 (1.5 or 2 mg/kg; ip). Subsequently, behavioral tests were applied to evaluate depressive-like behaviors. Finally, inflammatory cytokines were measured in the animals' brains and blood. A meta-analysis, including 11 experiments, was also conducted to evaluate if the NOPR activation contributes to inflammation. The studies’ weights, odds ratios, and confidence intervals were used to calculate the average effect size as the main outcome measure. The software SPSS v.29 and R programming language were used to analyze the data. The SDP and/or NOP agonist reduced distance traveled and exploration rate in the open field test. The SDP and/or the NOP agonist also increased immobility time in the tail suspension test, as well as reduced social interaction. Additionally, the NOP agonist increased the concentration of IL-6 and TNF alpha in the hippocampus, as well as reduced the IL-10 concentration in the hippocampus, but not in prefrontal cortex and serum. The SDP increased the concentration of IL-6 and TNF alpha in animals' serum and prefrontal cortex, but not in the hippocampus. The role of NOPR in neuroinflammation was regardless of the social defeat stress in the hippocampus. Meta-analysis also demonstrated the participation of NOPR activation in inducing inflammation in mice models. We suggest that upregulation of NOPR can activate signaling pathways involved in neuroinflammation, contributing to depression etiology.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 174-188"},"PeriodicalIF":3.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent impact of PTSD symptoms and alcohol use on working memory and executive functioning in a U.S. adult sample","authors":"Darrin M. Aase ,&nbsp;Stephanie McManimen ,&nbsp;Ryan Holliday ,&nbsp;Lindsey L. Monteith ,&nbsp;Craig J. Bryan","doi":"10.1016/j.jpsychires.2025.02.015","DOIUrl":"10.1016/j.jpsychires.2025.02.015","url":null,"abstract":"<div><div>Despite high comorbidity between posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) and well-documented independent impacts of each condition on cognitive functioning, few studies have explored the concurrent effects of PTSD and AUD on cognitive control. Recent intervention studies have explored working memory (WM) and executive functioning (EF) as potential treatment targets to improve outcomes for both PTSD and AUD, but there is a need to elucidate concurrent impacts of each condition to inform intervention development. The present study examined WM and EF performance in a sample of U.S. adults in relation to current PTSD symptom and alcohol use (AU) severity. We hypothesized that there would be main effects of both PTSD symptoms and AU severity on WM and EF outcomes, with an exploration of interaction effects. A sample of 112 participants (79% white, 61% female) recruited from a larger survey study also completed follow-up WM and EF tasks. Results did not support our hypotheses regarding main effects of PTSD and AU severity on WM and EF outcomes. Significant age effects were observed on WM measures such that higher age was associated with reduced performance. An interaction effect was detected for one EF measure (decision-making), such that decision-making performances were relatively stable at low to subthreshold PTSD symptoms regardless of AU severity but declined with increasing AU at clinically elevated PTSD symptoms. Findings reflect new information regarding the impact of concurrent PTSD and AU severity on EF, and implications for future research and intervention development are discussed.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 127-132"},"PeriodicalIF":3.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}