Journal of psychiatric research最新文献

{"title":"Updated meta-analysis of circulating glial cell line-derived neurotrophic factor levels in major depressive disorder: Clarifying case-control differences and treatment effects","authors":"Omran Davarinejad ,&nbsp;Saeid Komasi ,&nbsp;Mohammad-Taher Moradi ,&nbsp;Sepideh Nouraei ,&nbsp;Fatemeh Kazemisafa","doi":"10.1016/j.jpsychires.2025.09.030","DOIUrl":"10.1016/j.jpsychires.2025.09.030","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is a significant cause of disability, and glial cell line-derived neurotrophic factor (GDNF) plays a crucial role in its mechanisms. Previous findings on circulating GDNF levels in MDD have been inconsistent. This meta-analysis aims to clarify the relationship between GDNF levels in circulation and MDD by quantifying case-control differences and evaluating the impact of treatment on GDNF modulation.</div></div><div><h3>Methods</h3><div>A meta-analytic review was conducted involving 21 case-control studies with 2524 participants, including 1262 MDD patients and 1262 healthy controls, along with two intervention studies comprising 355 participants. GDNF levels were compared between the two groups, assessing pre- and post-treatment changes. A random-effects model was used to accommodate high heterogeneity, and meta-regression and subgroup analyses examined the influence of moderators such as age, sex ratio, depression severity, and methodological factors.</div></div><div><h3>Results</h3><div>GDNF levels were significantly lower in MDD patients compared to healthy controls (d = −0.78, p = 0.001), with high heterogeneity but no significant publication bias. GDNF reductions were most pronounced in treated patients, those with severe depression (HDRS &gt;19), and older patients. Serum GDNF levels were considerably lower in MDD patients, while plasma levels showed no significant difference. Meta-regression identified the female sex ratio as a significant moderator of GDNF levels. Therapeutic interventions significantly increased GDNF levels (d = 0.23, p = 0.035) with low heterogeneity.</div></div><div><h3>Conclusion</h3><div>Circulating GDNF levels are decreased in MDD patients, and increased by treatment. These findings support GDNF's capability as both a biomarker and therapeutic target for MDD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 119-128"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the Apollo Neuro device on anxiety among participants who underwent ketamine assisted therapy","authors":"Vivian W.L. Tsang ,&nbsp;Brendan Tao ,&nbsp;Raimey Olthuis ,&nbsp;Pearl Allard ,&nbsp;Saundarai Bhanot ,&nbsp;Sandra Wong ,&nbsp;Pamela Kryskow","doi":"10.1016/j.jpsychires.2025.09.032","DOIUrl":"10.1016/j.jpsychires.2025.09.032","url":null,"abstract":"<div><h3>Background</h3><div>The Apollo wearable device (wrist or ankle) is an investigational device which provides touch therapy with silent vibrations that may help individuals reduce the symptoms of stress such as difficulty breathing, sleeping or focusing on tasks. Positive feedback from a mental health treatment program that uses ketamine-assisted therapy as a treatment adjunct inspired researchers to assess the impact of the Apollo Neuro device on anxiety levels, comparing those using the device with those not using the device.</div></div><div><h3>Methods</h3><div>RTT-KAT is 12-weeks in length, with 30 min of curriculum, and 1.5 h of virtual CoP integration sessions each week. Patients receive group ketamine treatment at weeks 4,6,8 of the 12-week program. Intramuscular, gluteal, or deltoid injections of ketamine in the weight-based range of 0.5–1.5 mg/kg were used for each treatment. Doses ranged from 45 to 145 mg per session. The primary outcome measure was the change in Generalized Anxiety Disorder 7-item (GAD-7) scores, calculated as the difference between pre-GAD-7 and post-GAD-7 scores between patients with and without the Apollo Neuro device.</div></div><div><h3>Data analysis</h3><div>Data cleaning was performed to handle missing values and non-numeric entries. Propensity score matching was used to match participants from the “Apollo” and “Control” groups based on demographic and baseline GAD-7 scores. An independent sample <em>t</em>-test was conducted to compare the mean change in GAD-7 scores between the two groups.</div></div><div><h3>Results</h3><div>Sixteen Apollo participants and 18 Control group participants were included in final analysis. Shapiro test did not suggest non-normality of GAD-7 change over the duration of the treatment program. Without pre-balancing of age/sex/pre-gad-7, an independent Welch Two Sample <em>t</em>-test was conducted to compare the mean change in GAD-7 scores between the two groups. There was no significant difference (p = 0.572).</div></div><div><h3>Discussion</h3><div>Despite limitations of randomization and diversified participant groups, GAD-7 score analysis revealed median reduction in anxiety symptoms both with and without the Apollo Neuro device. However, with propensity-score balancing of baseline factors, there was no significant difference between the Apollo and Control groups (p = 0.63).</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 678-683"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, contributing factors, and clinical impact of apathy in Parkinson's disease","authors":"Lihua Gu ,&nbsp;Pengcheng Zhang ,&nbsp;Yanjuan Wang ,&nbsp;Yinwei Zhu ,&nbsp;Hongfei Li ,&nbsp;Hao Shu","doi":"10.1016/j.jpsychires.2025.09.031","DOIUrl":"10.1016/j.jpsychires.2025.09.031","url":null,"abstract":"<div><h3>Objective</h3><div>Apathy appears as a common neuropsychiatric symptom in Parkinson's disease (PD). This study aimed to investigate its prevalence, associated contributing factors, and clinical impact by a meta-analysis approach.</div></div><div><h3>Methods</h3><div>Studies published before October 2024 were retrieved from PubMed, Web of Science, and Google Scholar. Data were analyzed using STATA 12.0 software.</div></div><div><h3>Results</h3><div>The pooled prevalence of apathy in PD was 37 % [95 % confidence interval (CI): 32 %–42 %]. Compared with PD patients without apathy (PD-NA), PD patients with apathy (PD-A) were older [standard mean difference (SMD) = 0.25, 95 % CI: 0.19 to 0.32], more likely to be male (SMD = 1.06, 95 % CI: 1.00 to 1.12), and had lower educational levels (SMD = −0.29, 95 % CI: −0.40 to −0.18). Clinically, PD-A showed worse motor performance with higher scores on the Unified Parkinson's Disease Rating Scale III (SMD = 0.52, 95 % CI: 0.38 to 0.66) and Hoehn and Yahr stage (SMD = 0.29, 95 % CI: 0.13 to 0.46). They also exhibit more general cognitive impairment (SMD = −0.37, 95 % CI: −0.47 to −0.27), and greater depressive symptoms (SMD = 0.88, 95 % CI: 0.70 to 1.06). Therapeutically, PD-A required increased levodopa doses (SMD = 0.20, 95 % CI: 0.07 to 0.32) and more frequent use of antidepressants (SMD = 1.64, 95 % CI: 1.15 to 2.36).</div></div><div><h3>Conclusions</h3><div>Apathy is prevalent in PD and associated with greater motor, cognitive, and emotional dysfunction. Early identification and targeted interventions for apathy would improve the disease management and enhance the quality of life for PD patients.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 382-392"},"PeriodicalIF":3.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated risk of postpartum depressive symptoms among Arab women in Israel: The role of maternal role satisfaction and psychological flexibility","authors":"Samah Mahamid ,&nbsp;Miriam Chasson","doi":"10.1016/j.jpsychires.2025.09.026","DOIUrl":"10.1016/j.jpsychires.2025.09.026","url":null,"abstract":"<div><h3>Objectives</h3><div>Postpartum depressive symptoms (PPDS) are more prevalent among ethnic minority women, yet the psychological processes contributing to this disparity, particularly potential protective factors, remain insufficiently understood. Guided by Lazarus and Folkman's (1984) stress and coping model, this study examined the contribution of maternal role satisfaction and psychological flexibility to PPDS among Jewish and Arab mothers in Israel. In addition, we tested whether maternal role satisfaction mediates, and psychological flexibility moderates, the association between ethnicity and PPDS.</div></div><div><h3>Method</h3><div>A cross-sectional study was conducted in Israel with 476 postpartum women (288 Jewish, 188 Arab), recruited through convenience sampling via social media. The participants completed validated Hebrew or Arabic questionnaires assessing PPDS, maternal role satisfaction, and psychological flexibility. The analyses included <em>t</em>-tests, correlations, hierarchical regression, and a conditional process analysis testing mediation and moderation effects.</div></div><div><h3>Results</h3><div>Arab mothers reported higher PPDS and greater role satisfaction than Jewish mothers. Additionally, 23.9 % of Arab mothers and 9.7 % of Jewish mothers scored above the clinical cutoff for probable postpartum depression. Maternal role satisfaction (<em>β</em> = −0.61, <em>p</em> &lt; .001) and psychological flexibility (<em>β</em> = −0.35, <em>p</em> &lt; .001) were associated with lower PPDS. Maternal role satisfaction partially mediated the association between ethnicity and PPDS (<em>β</em> = −0.08, CI [−0.14, −0.05]), such that Arab mothers reported higher role satisfaction, which was associated with lower PPDS; however, psychological flexibility did not moderate this association.</div></div><div><h3>Conclusions</h3><div>Culturally sensitive interventions strengthening maternal role satisfaction may help to reduce postpartum distress and support resilience among minority mothers.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 87-94"},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between psychological resilience during pregnancy and infants’ neuropsychological development","authors":"Yifei Pei ,&nbsp;Xuan Zhang ,&nbsp;Cheng Yu ,&nbsp;Yiping Xiao ,&nbsp;Guoxiang Zhang ,&nbsp;Fenglin Cao","doi":"10.1016/j.jpsychires.2025.09.027","DOIUrl":"10.1016/j.jpsychires.2025.09.027","url":null,"abstract":"<div><h3>Background</h3><div>Adverse childhood experiences can have adverse health consequences for both mothers and their children. However, the effects of maternal psychological resilience as a positive factor in offspring development are unclear. This study therefore aimed to determine the association between maternal psychological resilience during pregnancy and the neuropsychological development of infants.</div></div><div><h3>Methods</h3><div>Among 346 mother-infant pairs, mothers were categorized into four groups based on ACE exposure and prenatal psychological distress. Linear regression analysis was conducted to examine the associations with infant outcomes.</div></div><div><h3>Results</h3><div>Compared to the Resilient group, infants of mothers in the Non-resilient group and the group with psychological distress but no adversity had higher (less favorable) scores in Approach and Adaptability (β = 2.124–3.113, <em>ps</em> &lt; 0.05). Infants of mothers in the Non-resilient group and those with psychological distress exhibited lower Gross and Fine motor skills scores (β = −0.23 to −2.41, <em>ps</em> &lt; 0.05). No significant differences were observed between the Resilient group and the group with neither adversity nor psychological distress.</div></div><div><h3>Conclusions</h3><div>This indicates that psychological resilience during pregnancy may buffer the negative effects of mothers' adverse childhood experiences on healthy developmental outcomes in offspring. These results can help guide the development of early intervention strategies aimed at breaking the intergenerational perpetuation of risk.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 129-137"},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and autonomic dysfunction in schizophrenia: Associations with symptom severity and onset subtypes","authors":"Chun-Hung Chang ,&nbsp;Hsin-Chi Tsai ,&nbsp;Sheng-Nan Wu ,&nbsp;Han-Ru Tan ,&nbsp;Wen-Chun Liu","doi":"10.1016/j.jpsychires.2025.09.025","DOIUrl":"10.1016/j.jpsychires.2025.09.025","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia (SCZ) is associated with elevated cardiometabolic risk, including obesity and autonomic dysfunction. Reduced heart rate variability (HRV), reflecting impaired autonomic nervous system (ANS) function, is linked to increased mortality.</div></div><div><h3>Methods</h3><div>Seventy inpatients with SCZ were evaluated using the Positive and Negative Syndrome Scale (PANSS). HRV was measured via a standardized 5-min protocol evaluating ANS balance, vagal activity (VAG), and standard deviation of normal-to-normal intervals (SDNN). HRV data from 112 age-matched healthy controls were included for comparison.</div></div><div><h3>Results</h3><div>SCZ patients exhibited significantly reduced SDNN compared to controls (17.8 ms vs. 40.5 ms, <em>p</em> &lt; 0.001). Older individuals with obesity exhibited higher HRV than younger, non-obese patients (SDNN: 27.8 ms vs. 14.3 ms, <em>p</em> = 0.019). Early-onset SCZ patients with BMI &lt;24 showed higher PANSS-N (28.3 vs. 22.1, <em>p</em> = 0.012) and PANSS-G scores (41.0 vs. 35.9, <em>p</em> = 0.049) without HRV differences. Conversely, late-onset cases, especially among non-obese patients, was associated with better ANS and VAG indices (ANS: PCC = 0.643, <em>p</em> = 0.01; VAG, PCC = 0.581, <em>p</em> = 0.023). Males had higher white blood cell counts, while females with BMI &lt;24 showed higher PANSS-N scores (<em>p</em> &lt; 0.05). Use of long-acting injectable antipsychotics was linked to higher PANSS-S in non-obese patients (7.4 vs. 4.1, <em>p</em> = 0.036).</div></div><div><h3>Conclusion</h3><div>Autonomic dysfunction is evident in SCZ, particularly in younger, non-obese individuals, and correlates with symptom severity and onset patterns. HRV and ANS metrics may serve as physiomarkers for risk stratification and personalized care.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 77-86"},"PeriodicalIF":3.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigational transcranial magnetic stimulation measures as predictors of aggression in schizophrenia: A cross-sectional study","authors":"Manul Das ,&nbsp;Sujeet Kumar ,&nbsp;Nishant Goyal ,&nbsp;Kommi Supriya Chowdary ,&nbsp;Subham Samantaray","doi":"10.1016/j.jpsychires.2025.09.023","DOIUrl":"10.1016/j.jpsychires.2025.09.023","url":null,"abstract":"<div><h3>Background</h3><div>Aggressive behaviors associated with schizophrenia are important determinants of the functional outcomes of the illness. Investigational transcranial magnetic stimulation (TMS) measures provide direct assessments of motor cortical inhibition, excitability, and plasticity, and these measures are known to be altered in individuals with schizophrenia. This study aimed to examine the association between these TMS measures and aggressive behavior in individuals with schizophrenia.</div></div><div><h3>Methods</h3><div>79 minimally treated patients with a diagnosis of schizophrenia as per DSM-5 were recruited for the study from Central Institute of Psychiatry, India. Short Interval Cortical Inhibition (SICI), Long Interval Cortical Inhibition (LICI), Cortical Silent Period (CSP), a proxy measure of recruitment gain (SI1mV - RMT), and measures of cortical plasticity were recorded, along with basic clinical data. The Modified Overt Aggression Scale (MOAS) was used to quantify total aggression scores.</div></div><div><h3>Results</h3><div>CSP (R = 0.322, p = 0.004), SICI (R = −0.33, p = 0.003) and SI1mV - RMT (R = 0.367, p = 0.0008) were significantly correlated with total MOAS scores. A multivariate linear regression model including CSP, SICI, and SI1mV - RMT explained 17 % of the variance in total MOAS scores (p = 0.0036, Cohen's f² = 0.2), indicating moderate predictive utility for clinical risk assessment. A multivariate logistic regression model with the same predictors achieved an AUC of 0.704 (p = 0.005) in distinguishing high aggressors (total MOAS score ≥10) from low aggressors. Despite the overall model being significant, none of the individual predictors reached statistical significance, suggesting possible interaction effects that warrant further exploration. Including other TMS measures and various clinical and sociodemographic variables did not improve the model fit.</div></div><div><h3>Conclusion</h3><div>TMS measures of cortical inhibition (SICI, CSP) and excitability (SI1mV - RMT) provide neurophysiological biomarkers for predicting aggressive behaviour in schizophrenia. This can potentially enable clinicians to identify high-risk patients for targeted interventions. Cross sectional design and moderate sample size are important limitations of the study.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 47-53"},"PeriodicalIF":3.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity characteristics of PTSD with anxiety and depression in patients with accidental injuries: Findings from joint cross-sectional and longitudinal studies","authors":"Weihang Chen ,&nbsp;Xiu Dai ,&nbsp;Xiangyuan Chu ,&nbsp;Xuheng Jiang ,&nbsp;Guojia Qi ,&nbsp;Shimin Zhao ,&nbsp;Yanna Zhou ,&nbsp;Xiuquan Shi","doi":"10.1016/j.jpsychires.2025.09.024","DOIUrl":"10.1016/j.jpsychires.2025.09.024","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to analyze the dynamic symptom interaction pathways and temporal causal relationships among post-traumatic stress disorder (PTSD), anxiety, and depression in patients with accidental injuries, and to establish a system of psychological intervention targets for this population.</div></div><div><h3>Methods</h3><div>This prospective longitudinal study was conducted from November 2023 to December 2024 in three tertiary general hospitals in Southwest China. Baseline assessments were completed 3–10 days post-trauma (T0), followed by follow-ups at 1 month (T1), 3 months (T2), and 6 months (T3).</div></div><div><h3>Results</h3><div>382 patients who completed T1 follow-up were included as the main analysis samples. The comorbidity rates of PTSD, anxiety and depression decreased gradually (T1 = 22.8 %, T2 = 21.2 %, T3 = 15.6 %). The longitudinal psychopathological network analysis showed that PTSD9 (Loss of interest) and D1 (Anhedonia) (edge weight = 0.22) were the main connections in T1 stage. In T2, A3 (Worrying) and D6 (Depressed mood) (edge weight = 0.30) were added. At T3 stage, there were positive emotional correlation between A4 (Relaxed feeling) and D7 (Enjoyment of activities) (edge weight = 0.21). Cross-lagged panel model analysis indicated that depressive symptoms positively predicted subsequent PTSD symptoms (T1 → T2: <em>β</em> = 0.583, <em>P</em> &lt; 0.01; T2 → T3: <em>β</em> = 0.792, <em>P</em> &lt; 0.05) and anxiety symptoms (T1 → T2: <em>β</em> = 0.268, <em>P</em> &lt; 0.05; T2 → T3: <em>β</em> = 0.282, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>There was a dynamic evolution of PTSD, anxiety, and depression following accidental injuries, highlighting the need to establish temporally targeted intervention pathways to disrupt the pathogenic process.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 107-114"},"PeriodicalIF":3.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the interrelations of obsessions, compulsions, and health: the mediating role of psychotic symptoms in individuals with obsessive-compulsive disorder","authors":"Gema Aonso-Diego ,&nbsp;Pamela Parada-Fernández ,&nbsp;Laura Mendo ,&nbsp;Laura Macía ,&nbsp;Ana Estévez ,&nbsp;Claudio Maruottolo","doi":"10.1016/j.jpsychires.2025.09.022","DOIUrl":"10.1016/j.jpsychires.2025.09.022","url":null,"abstract":"<div><h3>Background</h3><div>Despite the high comorbidity between obsessive-compulsive and psychotic symptoms, little is known about its impact on the health of individuals with obsessive-compulsive disorder (OCD). This study aimed to 1) explore the prevalence of psychotic symptoms in individuals with OCD, and 2) examine the mediating role of psychotic symptoms in the relationship between obsessive-compulsive symptoms and overall health.</div></div><div><h3>Methods</h3><div>This study included 102 participants undergoing treatment for OCD (<em>M</em>_age = 42.33, <em>SD</em> = 14.40, 52.9 % female). Structural equation modeling was employed to assess whether psychotic symptoms mediated the relationship between obsessive-compulsive symptoms and health outcomes.</div></div><div><h3>Results</h3><div>Among participants with OCD (from mild to severe), 53.9 % exhibited positive psychotic symptoms, 74.7 % presented negative psychotic symptoms, and 83.5 % showed depressive psychotic symptoms. A significant correlation was found between OCD symptoms and psychotic symptoms (<em>r</em> ranging from .338 to .512). Structural equation modeling indicated that psychotic symptoms fully mediated the relationship between compulsions and health.</div></div><div><h3>Conclusions</h3><div>Understanding the intricate relationship between OCD and psychotic symptoms remains a critical challenge in mental health research and clinical practice. Enhanced insights into this connection could facilitate more precise diagnoses and allow for more personalized treatments.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 54-61"},"PeriodicalIF":3.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of continuous theta burst stimulation (cTBS) in the treatment of auditory verbal hallucinations in Schizophrenia: A randomized controlled trial","authors":"Xiaoran Lv ,&nbsp;Tao Kong ,&nbsp;Kaili Zhang ,&nbsp;Xiaohua Yang ,&nbsp;Qiancheng Wang ,&nbsp;Jiaxing Xie ,&nbsp;Duanwei Wang ,&nbsp;Yunpeng He ,&nbsp;Xiaoxiao Shan","doi":"10.1016/j.jpsychires.2025.09.018","DOIUrl":"10.1016/j.jpsychires.2025.09.018","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have shown that schizophrenic patients with auditory verbal hallucinations (AVH) respond poorly to antipsychotic drugs. Continuous theta burst stimulation (cTBS), as a new type of repetitive transcranial magnetic stimulation (rTMS) treatment, has shown therapeutic effect on reducing AVH. This study aims to evaluate the efficacy of cTBS on alleviating AVH and other psychotic symptoms in schizophrenic patients with AVH.</div></div><div><h3>Methods</h3><div>A total of 56 patients with AVH were recruited, and 50 patients were screened and ultimately included in the study. They were randomly divided into an active (cTBS) group and a control (sham) group. The active group received cTBS treatment using the left temporoparietal junction as the stimulation target, while the control group received sham stimulation. Both groups underwent a 2-week treatment. The Positive and Negative Syndrome Scale (PANSS), Auditory Hallucination Rating Scale (AHRS), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were used to assess clinical symptoms and cognitive function at baseline and after 2 weeks of treatment.</div></div><div><h3>Results</h3><div>A total of 45 participants (25 in the active group and 20 in the sham group) completed the 2-week treatment. No significant difference (<em>P</em> &gt; 0.05) in AHRS scores, PANSS total and subscale scores, as well as scores of cognitive functions was found between the active and sham groups at the end of the treatment. Notably, no serious adverse events occurred during the treatment period, indicating the good safety of the cTBS treatment.</div></div><div><h3>Conclusions</h3><div>The results indicated that cTBS might not present a significant advantage over sham TBS in improving AVH symptoms of schizophrenia. However, future studies with longer treatment duration and larger sample size are required.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 70-76"},"PeriodicalIF":3.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}