Journal of psychiatric research最新文献

{"title":"Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways.","authors":"Sara V Maurer, Benjamin W Q Hing, Stephanie Lussier, Sreya Radhakrishna, Jada L B Davis, Parker W Abbott, Jacob J Michaelson, Hanna E Stevens","doi":"10.1016/j.jpsychires.2024.12.048","DOIUrl":"10.1016/j.jpsychires.2024.12.048","url":null,"abstract":"<p><p>Prenatal stress is a risk factor for neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD). However, how early stress modification of brain development contributes to this pathophysiology is poorly understood. Ventral forebrain regions such as dorsal striatum are of particular interest: dorsal striatum modulates movement and cognition, is altered in NDDs, and has a primarily GABAergic population. Here, we examine effects of prenatal stress on adult movement, cognition, and dorsal striatum neurobiology in mice using striatal-dependent behavioral assays, immunohistochemistry, embryonic ventral forebrain transcriptomics, and placental transcriptomics. We found prenatal stress affected adult procedural, habit, and reversal learning in sex-specific ways. Stress also increased adult dorsal striatal GABAergic neurons - an effect largely driven by males. We sought to examine the developmental origins of these adult brain changes. We found similar sex-specific dorsal striatal cellular changes in earlier points of development. The dorsal striatum primordium--embryonic ventral forebrain-showed that prenatal stress increased DNA replication and cell cycle pathways in male but not female transcriptomics and cellular biology. Unique signatures may have arisen from male-female placental differences. Stress-induced placental transcriptomics showed upregulated morphogenesis pathways in males while females downregulated morphogenic, hormonal, and cellular response pathways. Our findings suggest that prenatal stress could affect placenta function and also alter the GABAergic population of dorsal striatum differentially between the sexes.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"149-160"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Efficacy of accelerated deep transcranial magnetic stimulation with double cone coil in obsessive-compulsive disorder: A double-blind, placebo-controlled study\" [J. Psychiatr. Res. 171 (2024) 325-331].","authors":"Ufuk Ozer, Bengu Yucens, Selim Tumkaya","doi":"10.1016/j.jpsychires.2024.12.017","DOIUrl":"10.1016/j.jpsychires.2024.12.017","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"647"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of major depressive episodes and sleep architecture: an exploratory study.","authors":"Alessandro Sarzetto, Maria Cristina Cavallini, Federico Pacchioni, Francesca Casoni, Francesco Attanasio, Lorenzo Fregna, Luigi Ferini Strambi, Cristina Colombo","doi":"10.1016/j.jpsychires.2024.12.027","DOIUrl":"10.1016/j.jpsychires.2024.12.027","url":null,"abstract":"<p><p>Growing evidence supports sleep-wake disruption as a mechanism involved in mood disorders pathogenesis. Duration of depressive episodes varies widely, and longer depressive episodes have been connected to worse outcomes. We aimed to explore if the length of depressive episodes is related to objective modifications of sleep features. 35 subjects, aged 18-70, hospitalized for the treatment of a major depressive episode, either unipolar or bipolar, underwent polysomnography, upon admittance. Objective sleep features were correlated with the length of the ongoing depressive episode, measured in months. Positive correlations were found between the duration of the depressive episode and wake percentage (r = 0.358, p = 0.035), N3 latency (r = 0.451, p = 0.014) and wake after sleep onset (r = 0.342, p = 0,44). Our findings show that individuals suffering longer depressive episodes can experience objectively worse sleep features, in terms of increased night wakefulness and delayed deep sleep.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"596-598"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide risk among residents and PhD students: A systematic review of the literature.","authors":"Marianna Poli, Sophia Russotto, Michele Fornaro, Xenia Gonda, Jorge Lopez-Castroman, Fabio Madeddu, Patrizia Zeppegno, Carla Gramaglia, Raffaella Calati","doi":"10.1016/j.jpsychires.2024.12.013","DOIUrl":"10.1016/j.jpsychires.2024.12.013","url":null,"abstract":"<p><p>Residents and PhD students (any discipline) are susceptible to various mental health issues, including suicidal thoughts and behaviors. This systematic review aimed to (1) estimate the prevalence of suicide-related outcomes among residents/PhD students and (2) assess the associated variables. PubMed, PsycINFO, and Scopus databases were searched for articles documenting quantitative information about suicide-related outcomes among residents and PhD students from inception until April 30, 2023. Sixty studies were included. Estimates of the current prevalence of the following suicide-related outcomes were: death wishes (DW), 9.1%; suicidal ideation (SI), 8.6%; suicidal planning (SP), 3.2%; non-suicidal self-injury (NSSI), 1.9%; suicide attempt(s) (SA), .8%. Additionally, estimates of the lifetime prevalence were: lifetime SI (L-SI), 25.9%; lifetime SP (L-SP), 10.0%; lifetime SA (L-SA), 3.1%. Depression, burnout, hopelessness, loneliness, low quality of the relationship with the supervisor and experiencing workplace mistreatment frequently co-occurred with the assessed outcomes. Many outcomes (DW, SI, SP, L-SI, L-SP, L-SA) had a higher prevalence compared to the general population, while some (SI, NSSI, SA) were lower compared to undergraduates. Interventions for individuals at risk in this population are vital together with the modification of the work environment and the promotion of a supportive academic and professional culture to reduce suicide risk.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"433-462"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota changes are associated with abnormal metabolism activity in children and adolescents with obsessive-compulsive disorder.","authors":"Jiali Dai, Min Li, Juan He, Li Duan, Xiaotong Zhu, Lu Liu, Ming Meng, Xiaojun Shao, Gang Zhu","doi":"10.1016/j.jpsychires.2024.12.041","DOIUrl":"10.1016/j.jpsychires.2024.12.041","url":null,"abstract":"<p><p>Obsessive-compulsive disorder (OCD) is a chronic and disabling psychiatric disorder characterized by recurrent intrusive thoughts or repetitive behaviors. We sought to better understand the structure of gut microbiota in first visit registration, treatment-naive children and adolescents with OCD, and the relationship between gut microbiota and fecal metabolites. Thus we studied the gut microbial population using 16 S rRNA sequencing in 49 children (8-17 years of age) with OCD, 42 healthy controls (HCs). We found a significant decrease in α-diversity in the OCD group, and the OCD and HC groups had distinctive intestinal flora. To further investigate the potential interaction effects between OCD and functional pathways of the intestinal flora, the 19 OCD patients and 18 aged-matched HCs were selected to undergo metagenomics analysis. We showed that several functional pathways of gut microbiota in patients with OCD were disrupted, such as glucolipid metabolism, amino acid metabolism, steroid biosynthesis, and the second messenger system. Changes in the clinical characteristics of OCD patients were associated with specific bacteria. Metabolomics analysis was also performed on stool samples from 91 subjects. Intestinal microflora metabolite expression in OCD patients was disturbed, and the related metabolic pathway functions were abnormal. Abnormal metabolites of gut microbiota in OCD patients are mainly involved in folate biosynthesis, the prion disease pathway, and the amino acid metabolic network. This study detailed the intestinal microbiota of children and adolescents with OCD. Our study suggests possible modalities for early OCD intervention by targeting the specific bacteria associated with neurotransmitter metabolism.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"728-737"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bias toward escape responding during reinforcement learning among those with suicidal ideation.","authors":"Miguel Blacutt, Caitlin M O'Loughlin, Brooke A Ammerman","doi":"10.1016/j.jpsychires.2024.12.020","DOIUrl":"10.1016/j.jpsychires.2024.12.020","url":null,"abstract":"<p><p>Self-injury and suicide can be characterized by reward system dysfunction and self-reports of active efforts to escape unpleasant emotional states. Therefore, individuals with histories of suicidal ideation (SI) should exhibit a preference for active escape from unpleasant states, which exceed the effects of impulsive behavior under distress and lack of premeditation. Participants made active (Go) or passive (No-Go) choices in response to stimuli to escape or avoid an unpleasant state in a behavioral task. A drift-diffusion reinforcement learning model was used to estimate latent biases for active escape and avoidance in people with and without SI history. Bayesian logistic regression was used to examine the relationship between escape and avoid bias with SI. Escape bias predicted SI history, whereas avoidance bias did not. Escape bias remained a significant predictor of SI when controlling for negative urgency and lack of premeditation. Those with histories of SI demonstrate a decision-making bias favoring escape from aversive states. This bias remains significant after adjusting for facets of impulsivity linked to hasty decisions under distress and lack of premeditation. A heightened escape response may help clinicians to identify SI risk and develop targeted treatments to attenuate the escape bias.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"586-595"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the physical health of overweight/obese people suffering from severe mental disorders: What is the role of antipsychotic drugs and of lifestyle psychosocial interventions?","authors":"Gaia Sampogna, Matteo Di Vincenzo, Mario Luciano, Bianca Della Rocca, Enrico D'Ambrosio, Antonio Rampino, Mario Amore, Pietro Calcagno, Alessandro Rossi, Rodolfo Rossi, Liliana Dell'Osso, Barbara Carpita, Cinzia Niolu, Alberto Siracusano, Andrea Fiorillo","doi":"10.1016/j.jpsychires.2024.11.029","DOIUrl":"10.1016/j.jpsychires.2024.11.029","url":null,"abstract":"<p><p>People with severe mental disorders experience premature mortality compared with the general population. Several factors contribute to the mortality gap, including the adoption of unhealthy lifestyle behaviours, poor screening for physical illnesses, difficulties in accessing healthcare facilities, specific clinical features of mental disorders and some pharmacological treatment such as antipsychotic medications with serious metabolic side effects. In the present study, carried out in the framework of the LIFESTYLE trial, a funded nationwide multicentric study, we aimed to assess the impact of different antipsychotics in mediating the effectiveness of psychosocial intervention on healthy lifestyle behaviours. The antipsychotics have been grouped in metabolically more problematic (MMP) vs. metabolically less problematic (MLP). The final sample consists of 401 participants with a mean age of 45.6 ± 11.8 years, mainly female (57.1%), suffering from bipolar disorder (43.4%), schizophrenia spectrum disorders (29.7%) and depressive disorders (26.9%). 36.2% of patients (N = 145) received MMP antipsychotics, 32.2% were treated with MLP antipsychotics and 31.6% did not take any antipsychotic medication, but were treated with antidepressants, mood stabilizers and/or benzodiazepines. At 6-month follow-up, patients receiving the experimental lifestyle intervention and treated with MLP medication reported a significant reduction in BMI (p < .05). Our findings clearly indicate that a multilevel, personalized and individualized therapeutic approach for the treatment of patients with severe mental disorders is needed, with the involvement of different physicians and health providers for an appropriate long-term management of patients with severe mental disorders.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"570-578"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic prediction of blood metabolites mediating the relationship between gut microbiota and postpartum depression: A mendelian randomization study.","authors":"Zhan Gao, Runze Zhou, Zhiqiang Chen, Haotian Qian, Chendong Xu, Mingzhou Gao, Xi Huang","doi":"10.1016/j.jpsychires.2024.12.025","DOIUrl":"10.1016/j.jpsychires.2024.12.025","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have suggested an association between gut microbiota(GM) and postpartum depression (PPD). However, the causal relationship remains unclear, and the role of blood metabolites in this association remains elusive.</p><p><strong>Methods: </strong>This study firstly elucidated the causal relationship among 196 GM taxa, 224 blood metabolites, and PPD from a genetic perspective, employing two-sample Mendelian randomization (MR). Subsequently, a two-step mediation MR approach was employed to explore the role of blood metabolites as potential mediators. To validate the relevant findings, we further selected other data (GM and blood metabolites) from the IEU Open GWAS and GWAS Catalog for analysis. Our primary analysis utilized the inverse variance weighted method. To enhance the robustness of our results, we also applied MR-Egger method, weighted median method, Cochran's Q test, MR-Egger regression, and MR-PRESSO.</p><p><strong>Results: </strong>MR analysis results revealed a nominal association (p < 0.05) between 13 GM taxa, 6 blood metabolites, and PPD. After multiple-testing correction (P_FDR < 0.1), Bifidobacteriales (P_FDR = 0.034), Bifidobacteriaceae (P_FDR = 0.055) and Guanosine (P_FDR = 0.081) showed significant causal relationships with PPD. In our validation results, the higher level of Alphaproteobacteria (OR: 1.057, 95% CI: 1.024-1.091; p = 0.0006) retained a causal relationship with a higher risk of PPD. Finally, mediation analysis revealed that the impact of Odoribacter on PPD was mediated indirectly through Hyodeoxycholate, with a mediation proportion of 16.8%.</p><p><strong>Conclusion: </strong>Our findings elucidated the underlying mechanisms between the GM, blood metabolites, and PPD. These findings contribute to the prevention and diagnosis of PPD, offering novel insights into microbiome-based therapies and metabolite-targeted interventions for the treatment of PPD.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"614-622"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide in Italy during the COVID-19 pandemic: Excess mortality in 2021 among men and adolescent girls.","authors":"Enrico Grande, Francesco Grippo, Stefano Marchetti, Luisa Frova","doi":"10.1016/j.jpsychires.2024.11.063","DOIUrl":"10.1016/j.jpsychires.2024.11.063","url":null,"abstract":"<p><p>During the COVID-19 pandemic populations have been exposed to unprecedented and prolonged psychosocial distress that may have adversely affected mental health and suicidal behavior, especially in specific subgroups of the population. This study aims to evaluate possible excess suicide mortality in Italy during 2021 according to sex and age group. Cause-of-death data were used to analyze suicide deaths in the whole resident population in Italy aged ≥10 years. Excess suicide mortality according to sex and age group was evaluated by comparing observed deaths to expected deaths estimated using Poisson regression models fitted to 2011-2019 data, to capture pre-pandemic temporal trends. In Italy, during 2021 overall suicide mortality increased in both sexes, showing a significant excess in the male population compared to expected levels based on the pre-pandemic temporal trend. The number of male suicides was higher than expected in all age groups, with significant excesses for ages 25-34 or 65-84 years. A significantly high excess was found among females aged 10-24 years. Findings suggest monitoring the long-term effect of the COVID-19 pandemic on suicide mortality and targeting interventions on specific age groups of both male and female populations, especially adolescent girls.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"282-285"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences and defensive gun use: The indirect role of threat sensitivity and depressive symptoms.","authors":"Sultan Altikriti, Daniel C Semenza, Alexander Testa, Dylan B Jackson, Michael D Anestis","doi":"10.1016/j.jpsychires.2024.12.030","DOIUrl":"10.1016/j.jpsychires.2024.12.030","url":null,"abstract":"<p><strong>Background/purpose: </strong>Adverse childhood experiences (ACEs) have been linked to various detrimental life outcomes, including an increase in threat sensitivity and depressive symptoms. Studies have also found an association between ACEs and firearm ownership. To date, no study has assessed whether ACEs have direct or indirect effects on defensive gun use (DGU) through these risk factors.</p><p><strong>Methods/approach: </strong>This study used structural equation modeling to estimate the role of threat sensitivity and depressive symptoms in the direct and indirect relationships between ACEs and DGU in a subsample of adults with firearm access (n = 3130) drawn from a recent, nationally representative sample of U.S. adults.</p><p><strong>Results: </strong>ACEs had significant (p < .05) and positive associations with threat sensitivity (β = 0.246), depressive symptoms (β = 0.291), and DGU (β = 0.093). ACEs also exhibited a significant indirect relationship with DGU through threat sensitivity (β = 0.012) but not depressive symptoms. The indirect relationship between ACEs and DGU through threat sensitivity accounted for 11% of the total effect of ACEs on DGU.</p><p><strong>Conclusions/implications: </strong>The findings suggest that ACEs are associated with increased DGU through threat sensitivity. Policy targeting the prevention of ACEs may help reduce DGU, indirectly reducing injury and gun violence. Future research on the impact of ACEs on DGU should identify other externalizing mechanisms that potentially account for this association.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"695-700"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}