Journal of psychiatric research最新文献

{"title":"Predicting mental health disorder onsets with Fibonacci sequencing: A genetic and epigenetic perspective","authors":"Rob G. Sacco ,&nbsp;Bernard B. Beitman ,&nbsp;Terry Marks-Tarlow","doi":"10.1016/j.jpsychires.2025.02.036","DOIUrl":"10.1016/j.jpsychires.2025.02.036","url":null,"abstract":"<div><div>This study explores a novel intersection between molecular biology, genomics, and mathematical modeling to predict the onset patterns of mental health disorders. By investigating the alignment between the Fibonacci sequence and the timing of genetic and epigenetic events, this research seeks to uncover whether these patterns can serve as a predictive model for the onset of disorders such as schizophrenia, bipolar disorder, and major depressive disorder. Leveraging epidemiological data and advanced time-series analysis, the study examines how the temporal progression of molecular markers corresponds to clinical manifestation ages in mental health disorders. Findings indicate that specific ages of disorder onset show significant alignment with Fibonacci harmonics, suggesting a potential natural synchrony within biological processes. This interdisciplinary approach could enhance predictive accuracy, supporting early intervention and personalized mental health strategies, and offering a new perspective on the molecular underpinnings of psychiatric conditions.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 237-243"},"PeriodicalIF":3.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enterobacterial caseinolytic protease B (ClpB) and ClpB antibodies in adolescents with anorexia nervosa","authors":"Benjamin Thomas ,&nbsp;Nadia Andrea Andreani ,&nbsp;Emilie Lahaye ,&nbsp;John F. Baines ,&nbsp;Beate Herpertz-Dahlmann ,&nbsp;Jochen Seitz ,&nbsp;Sergueï O. Fetissov","doi":"10.1016/j.jpsychires.2025.02.034","DOIUrl":"10.1016/j.jpsychires.2025.02.034","url":null,"abstract":"<div><div>Caseinolytic protease B (ClpB) produced by the gut enterobacteria displays anorexigenic effects possibly due to its molecular mimicry with α-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropeptide. ClpB is known to induce α-MSH cross-reactive antibodies previously associated with eating disorders. In the present study we analyzed whether long-term changes of serum ClpB, anti-ClpB antibodies and fecal <em>clpB</em> gene content can be associated with disease progression in anorexia nervosa (AN). For this purpose, female adolescents diagnosed with the restrictive type of AN according to DSM-5 were studied at hospital admission, discharge, and at a 1-year follow up visit, while age-matched healthy female participants served as a control group. We found that ClpB protein was detected at variable levels in sera of all study participants without significant group differences. However, anti-ClpB IgG were low in adolescents with AN at the acute phase of disease and were characterized by increased affinity. Long-term individual dynamics of serum ClpB revealed that its increase after hospital discharge was associated with disease relapse. In healthy adolescents, serum ClpB correlated negatively with BMI-SDS. Fecal <em>clpB</em> DNA levels were low in patients at hospital admission and discharge correlating positively with the abundance of Enterobacteriaceae in gut microbiota. Thus, in healthy adolescents enterobacterial ClpB appears as a physiological microbiota-derived factor associated with lower body weight within the normal range. Low levels of anti-ClpB IgG in adolescents with AN may cause insufficient immune control of ClpB, possibly promoting ClpB anorexigenic effects which can be relevant to the pathophysiology of AN.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 8-16"},"PeriodicalIF":3.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypogyrification in the medial regions of the temporal and occipital lobes in hoarding disorder","authors":"Akira Matsuo ,&nbsp;Hirofumi Tomiyama ,&nbsp;Keitaro Murayama ,&nbsp;Kenta Kato ,&nbsp;Nami Nishida ,&nbsp;Kou Matsukuma ,&nbsp;Makoto Kawahito ,&nbsp;Kana Tsunoda ,&nbsp;Mingi Kang ,&nbsp;Kenta Sashikata ,&nbsp;Osamu Togao ,&nbsp;Koji Yamashita ,&nbsp;Kazufumi Kikuchi ,&nbsp;Tatsuhiro Wada ,&nbsp;Tomohiro Nakao","doi":"10.1016/j.jpsychires.2025.02.040","DOIUrl":"10.1016/j.jpsychires.2025.02.040","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 244-251"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A wave of COVID-19 related PTSD? Disentangling the impact of exposure to COVID-19 related events on probable posttraumatic stress disorder in the general Dutch population","authors":"Anouk van Duinkerken ,&nbsp;Mark W.G. Bosmans ,&nbsp;Meaghan O'Donnell ,&nbsp;Christos Baliatsas ,&nbsp;Michel L.A. Dückers","doi":"10.1016/j.jpsychires.2025.02.032","DOIUrl":"10.1016/j.jpsychires.2025.02.032","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic highlighted a critical gap in our knowledge on the impact on mental health, especially trauma-related disorders like PTSD. With future pandemics anticipated due to global health risks, it is essential to rigorously study the prevalence of PTSD resulting from COVID-19. Such research will help us understand the psychological effects of pandemics and develop better strategies for mental health support in future crises.</div></div><div><h3>Methods</h3><div>This study uses data from the Dutch Public Health Monitor Adults and Elderly 2022, consisting of 365,000 Dutch adults recruited using random sampling. Pandemic-related and non-COVID related potentially traumatic events were assessed and anchored to a validated screening instrument for PTSD, the Dutch version of the PCL-5.</div></div><div><h3>Results</h3><div>Two-thirds of participants reported experiencing traumatic events during the pandemic. Exposure to pandemic-related traumatic events was reported more frequently than non-COVID related traumatic events. Overall probable PTSD prevalence due to these events was 2.4%, evenly split between pandemic-related and non-COVID related traumatic events. Among exposed individuals, probable PTSD prevalence was 3.7%. The risk was higher for exposure to non-COVID related events such as sexual violence, physical violence and life-threatening accidents than exposure to pandemic-related traumatic events like hospitalization or death of someone significant. Risk factors for developing probable PTSD after exposure to a traumatic event during the pandemic were younger age, financial difficulties, loneliness, low resilience, and experiencing multiple events.</div></div><div><h3>Discussion</h3><div>Exposure to traumatic events during the pandemic influenced the prevalence of probable PTSD. Despite the lower relative impact of pandemic-related traumatic events compared to non-COVID related traumatic events, exposure to pandemic-related traumatic events accounted for 1.1% of probable PTSD in the population and is thereby comparable in impact to five commonly occurring traumatic events. This emphasizes the need to address mental health consequences and risk factors during pandemics and, potentially, other crises with population-wide exposure to events.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 39-47"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of depression and anxiety with coronary artery plaque among asymptomatic adults: The Miami Heart study (MiHeart) at Baptist Health South Florida","authors":"Tanvi Bafna ,&nbsp;Omar Dzaye ,&nbsp;Zeina Dardari ,&nbsp;Miguel Cainzos-Achirica ,&nbsp;Ron Blankstein ,&nbsp;Theodore Feldman ,&nbsp;Matthew J. Budoff ,&nbsp;Jonathan Fialkow ,&nbsp;Khurram Nasir ,&nbsp;Michael J. Blaha","doi":"10.1016/j.jpsychires.2025.02.037","DOIUrl":"10.1016/j.jpsychires.2025.02.037","url":null,"abstract":"<div><h3>Purpose</h3><div>We investigated the associations of depression and anxiety with the presence of coronary artery plaque amongst a diverse cohort of adults without clinical atherosclerotic cardiovascular disease.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed data from the Miami Heart Study at baseline. Depression was ascertained by the 8-item Patient Health Questionnaire (PHQ-8) with a score ≥10 indicating depression. Anxiety was assessed by the Generalized Anxiety Disorder 7-item (GAD-7) questionnaire with a score ≥10 demonstrating anxiety. Multivariable logistic regression models were used to analyze the association of either depression or anxiety with the presence of any plaque on CCTA. Sensitivity analyses further examined the severity of depressive symptoms, severity of anxiety symptoms, individuals with either depression or anxiety, and individuals with both as predictors of coronary plaque.</div></div><div><h3>Results</h3><div>Of the 2356 individuals (mean age 53.4 ± 6.8 years), 50.4% were men and 47.1% were of Hispanic ethnicity. Depression and anxiety were identified in 143 (6.1%) and 224 (9.5%) of individuals, respectively. CCTA-identified plaque was present in 49.0% of participants with depression and 54.0% of those with anxiety, and the presence of any plaque did not significantly differ when compared to those without depression or without anxiety, respectively. There were no statistically significant associations between depression and plaque (adjusted odds ratio [aOR]: 1.03; 95%CI [0.70, 1.52]; p = 0.891) or between anxiety and plaque (aOR: 1.27; 95%CI [0.93, 1.73]; p = 0.138) in all regression models.</div></div><div><h3>Conclusions</h3><div>Our study did not identify an association of depression, anxiety, their combination, or their severity with coronary plaque on CCTA among a large cohort of asymptomatic adults.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 219-224"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbes: Therapeutic Target for neuropsychiatric disorders","authors":"Keya Mallick ,&nbsp;Gopal Khodve ,&nbsp;Ritika Ruwatia,&nbsp;Sugato Banerjee","doi":"10.1016/j.jpsychires.2025.02.031","DOIUrl":"10.1016/j.jpsychires.2025.02.031","url":null,"abstract":"<div><div>Neuropsychiatric diseases encompass a range of mental and neurological disorders that have a significant and far-reaching effect on an individual's quality of life. These conditions affect not only the mental status but also the physical well-being of individuals, which leads to weakened immune systems and other diseases. Emerging research underscores a significant connection between the gut microbiome and neuropsychiatric diseases, suggesting that microbial communities within the gastrointestinal tract may influence brain function and mental health. Gut dysbiosis is caused by various factors, including stress, diet, inappropriate usage of antibiotics, infections, and so on, all of which can disrupt numerous pathways, resulting in abnormal neurotransmitter signaling, inflammation, and impaired brain function. Similarly, various neuropsychiatric diseases can disrupt the specific microbiome in the gut, leading to gut dysbiosis, often impairing memory and cognitive function. The growing evidence supporting the role of gut dysbiosis in neuropsychiatric disorders has opened up new avenues for therapeutic interventions. Modulating the gut microbiome through strategies such as probiotics, prebiotics, or fecal microbiota transplantation has shown promising results in various studies of neuropsychiatric disorders. However, further research is needed to fully elucidate the mechanisms involved in gut dysbiosis-associated brain changes to develop effective and personalized treatment strategies for neuropsychiatric diseases.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 27-38"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal effects of disaster-related experiences on concern and its impact on depressive symptoms among Fukushima nuclear power plant workers: The Fukushima NEWS project study","authors":"Tomokazu Tajima ,&nbsp;Ai Ikeda ,&nbsp;Jun Shigemura ,&nbsp;Takeshi Tanigawa","doi":"10.1016/j.jpsychires.2025.02.022","DOIUrl":"10.1016/j.jpsychires.2025.02.022","url":null,"abstract":"<div><h3>Background</h3><div>The 2011 Fukushima nuclear disaster affected the mental health of nuclear plant workers.</div></div><div><h3>Objective</h3><div>The study aimed to explore the longitudinal relationship between workers’ disaster-related experiences and concern, and the impact of concern on depressive symptoms over three years.</div></div><div><h3>Method</h3><div>A total of 1347 workers from Fukushima Daiichi and Daini nuclear power plants participated. Three types of concern (work, life, or health-related) and depressive symptoms were assessed from 2012 to 2014 using self-reporting concern questionnaires and the Center for Epidemiologic Studies Depression Scale (CES-D). The relationships between disaster-related experiences and concern and depressive symptoms (CES-D score ≥16) were analyzed using mixed-effects models, as were the associations between type of concern and depressive symptoms. Stratified analyses for all associations were performed according to work location in 2011.</div></div><div><h3>Results</h3><div>Each type of concern was associated with different disaster-related experiences. Depressive symptoms were associated with job-related concern (β = 0.015, <em>p</em> &lt; 0.011), life-related concern (β = 0.018, <em>p</em> = 0.002), and health-related concern (β = 0.018, <em>p</em> &lt; 0.001), and these associations remained over two years. The associations were more evident in Daiichi plant workers, while Daini plant workers only exhibited significant associations with health-related concern.</div></div><div><h3>Conclusions</h3><div>Different disaster-related experiences affected plant workers' concern. The risk of depressive symptoms was significant among workers with any of the three types of concern, particularly for Daiichi plant workers. It is important to understand plant workers’ concern and their experiences during the disaster to guide them towards mental health support and clinical interventions.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 163-169"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-feature fusion method combining brain functional connectivity and graph theory for schizophrenia classification and neuroimaging markers screening","authors":"Chang Wang ,&nbsp;Yaning Ren ,&nbsp;Rui Zhang ,&nbsp;Jiyuan Zhang ,&nbsp;Xiao Li ,&nbsp;Xiangyu Chen ,&nbsp;Jiefen Shen ,&nbsp;Zongya Zhao ,&nbsp;Yongfeng Yang ,&nbsp;Wenjie Ren ,&nbsp;Yi Yu","doi":"10.1016/j.jpsychires.2025.02.025","DOIUrl":"10.1016/j.jpsychires.2025.02.025","url":null,"abstract":"<div><h3>Background</h3><div>The abnormalities in brain functional connectivity (FC) and graph topology (GT) in patients with schizophrenia (SZ) are unclear. Researchers proposed machine learning algorithms by combining FC or GT to identify SZ from healthy controls. The schizophrenia classification and neuroimaging markers screening using FC and GT feature fusion are blank.</div></div><div><h3>Methods</h3><div>We proposed multi-feature fusion method combining functional connectivity and graph topology for schizophrenia classification and neuroimaging markers screening. Firstly, we acquired and preprocessed the private rs-fMRI data from the second affiliated hospital of Xinxiang Medical University in china. Secondly, we calculated the functional connectivity matrix and graph topology features. Thirdly, we used the two-sample <em>t</em>-test and the minimum absolute contraction selection operator (LASSO) to extract the features with statistical differences. Lastly, we used machine learning to classify schizophrenia and screen neuroimaging markers.</div></div><div><h3>Results</h3><div>The result showed that the SVM model with the best feature (i.e., FC and GT) has the best performance (ACC = 0.935(95 percent confidence interval, 0.932 to 0.938), SEN = 0.920(95 percent confidence interval, 0.917 to 0.922), SPE = 0.950(95 percent confidence interval, 0.946 to 0.954), F1 = 0.935(95 percent confidence interval, 0.933 to 0.938), AUC = 0.935(95 percent confidence interval, 0.932 to 0.937)). We also found that the differences in FC and GT features are mainly located in the default network, the attention network, and the subcortical network. The feature strength of FC and GT showed a general decline in patients with SZ, and the node clustering coefficient of the thalamus and the FC of Putamen_L and Frontal_Mid_Orb_R showed an increase.</div></div><div><h3>Conclusion</h3><div>It demonstrated that the multi-feature fusion has the advantage in distinguishing SZ from healthy individuals providing new insights into the underlying pathogenesis of SZ.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 260-268"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental effects of omega-3 fatty acids and its combination with Methylphenidate in iPSC models of ADHD","authors":"Natalie M. Walter ,&nbsp;Cristine M. Yde Ohki ,&nbsp;Sina Ruhstaller ,&nbsp;Letizia Del Campana ,&nbsp;José Maria Salazar Campos ,&nbsp;Lukasz Smigielski ,&nbsp;Belén Rubio ,&nbsp;Susanne Walitza ,&nbsp;Edna Grünblatt","doi":"10.1016/j.jpsychires.2025.02.035","DOIUrl":"10.1016/j.jpsychires.2025.02.035","url":null,"abstract":"<div><div>Attention-Deficit/Hyperactivity Disorder (ADHD) has been linked to altered neurodevelopmental processes, including proliferation and differentiation of neural stem cells (NSC). We aimed to investigate the role of Wnt signaling, a pathway critical for brain development, in ADHD and to determine if modulation of this pathway using ω-3/6 polyunsaturated fatty acids (PUFAs) may provide a beneficial treatment approach. Given the symptom heterogeneity in ADHD and the limited response to conventional therapies for some patients, we examined the effects of ω-3/6 PUFA treatment combined with Methylphenidate (MPH) on neurodevelopmental mechanisms using induced pluripotent stem cell (iPSC)-derived NSCs, comparing controls to ADHD patients. Our results show that ω-3/6 PUFAs differentially regulate Wnt activity in NSCs depending on the patient's condition and the composition of the treatments. These findings highlight the potential of ω-3 PUFA treatment as personalized support for neurodevelopmental processes in ADHD. They also emphasize the importance of investigating ADHD subgroups, including those unresponsive to stimulant treatments, as they may exhibit distinct phenotypes.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 78-90"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does multimodal exercise reduce C-reactive protein levels in major depressive disorder? Preliminary results from a randomized controlled trial","authors":"Vagner Deuel de O. Tavares ,&nbsp;Felipe B. Schuch ,&nbsp;Geovan Menezes de Sousa ,&nbsp;Mats Hallgren ,&nbsp;Megan Teychenne ,&nbsp;Raissa Nóbrega de Almeida ,&nbsp;Rodrigo Vieira Browne ,&nbsp;Maria Luiza Barros ,&nbsp;Renali Camilo Bezerra ,&nbsp;Jaime Eduardo Hallak ,&nbsp;Emerson Arcoverde ,&nbsp;Scott Patten ,&nbsp;Colleen Cuthbert ,&nbsp;Nicole Leite Galvão-Coelho","doi":"10.1016/j.jpsychires.2025.02.023","DOIUrl":"10.1016/j.jpsychires.2025.02.023","url":null,"abstract":"<div><div>This randomized controlled trial aimed to evaluate the adjunctive effects of an affect-based, supervised, multimodal, online, and home-based exercise intervention on C-reactive protein (CRP) levels and depressive symptoms by comparing it to pharmacotherapy alone (antidepressants) over a 12-week period. The study specifically focused on CRP levels and their association with depression outcomes. Depressive symptoms and blood samples were assessed before (baseline – t0), during (Week 5 – t1), and at end of treatment (Week 12 – t2). The exercise intervention was designed to optimize positive affect during and after exercise, and considered each participant's preferred exercise intensity to enhance perceived effort, pleasure, and enjoyment. The study enrolled 59 adults and randomly allocated them into two groups: exercise group (EG; n = 26,76.9% females, mean age 28.5 years) and control group (CG, n = 33, 78.7% females, mean age 25.9 years). CRP levels reduced in the EG at t2 compared with t0 [p = .019; d = .64 (CI 95% −.04,1.24)], while the CRP did not change during treatment in the CG [p = .116; d = −.35 (CI 95% −.93,.16)]. At t2, EG showed clinically meaningful reductions in CRP compared to CG: [p = .043; d = .50 (CI 95% .14,1.30)]. For EG, the anti-inflammatory response predicted reductions in self-reported depressive symptoms (t = 2.066, β = .438, p = .030). Given the significant role inflammation plays in modulating depression symptoms, our findings indicate that structured multimodal exercise programs, which can be delivered online, are effective in the management of depression and potentially have anti-inflammatory.</div></div><div><h3>Trial registration number</h3><div>Brazilian Registry of Clinical Trials (ReBEC: RBR-4pgd3ct); Date of registration: 10/19/2023.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 252-259"},"PeriodicalIF":3.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}