{"title":"Increased risk of herpes zoster associated with stress and sleep deprivation: Evidence from korea health panel survey","authors":"Youjin Kim, Wanhyung Lee","doi":"10.1016/j.jpsychires.2025.03.015","DOIUrl":"10.1016/j.jpsychires.2025.03.015","url":null,"abstract":"<div><h3>Objective</h3><div>Several studies have reported controversial results regarding the association between mental health factors and the risk of herpes zoster. This study examined the effects of self-rated stress, sleep deprivation, depressive symptoms, and suicidal ideation on the risk of herpes zoster.</div></div><div><h3>Methods</h3><div>Data from the Korea Health Panel Survey (2008–2018) were analyzed. Associations between self-reported mental health factors and herpes zoster were determined using a generalized estimating equation model. Age, sex, socioeconomic status, health behaviors, and comorbidities were adjusted for in the model. The standardized incidence ratios (SIRs) were reported from the sensitivity analysis.</div></div><div><h3>Results</h3><div>Of the 78,896 included person-years (mean age, 51.31 ± 16.90; females, n = 43,503 [55.14 %]), 1130 (1.43 %) developed herpes zoster. The adjusted odds ratios (aORs) for the association between severe self-rated stress and herpes zoster were 1.483 (95 % confidence interval [CI]: 1.161–1.895) and for sleep deprivation, 1.194 (95 % CI: 1.038–1.374). When stratified by sex, the association remained significant in females but not in males. For depressive symptoms and suicidal ideation, the adjusted models did not reveal significant associations with herpes zoster infection. In the sensitivity analysis, the SIRs for herpes zoster were higher with severe self-rated stress (1.37, 95 % CI: 1.07–1.68) and sleep deprivation (1.21, 95 % CI: 1.07–1.36).</div></div><div><h3>Conclusions</h3><div>Severe self-rated stress and sleep deprivation were associated with an increased risk of herpes zoster, whereas depressive symptoms and suicidal ideation were not. Further studies are required to confirm these findings and explore additional factors.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 333-339"},"PeriodicalIF":3.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huafeng Wei , Qianqian Xin , Yihong Cheng , Zhihong Lv , Wenjuan He , Miaoqin Tan , Meiqi Lin , Shuqiong Zheng , Junlong Guo , Bin Zhang
{"title":"Neural responses to social decision-making and their associated factors among nonsuicidal self-injured adolescents: An event-related potentials study","authors":"Huafeng Wei , Qianqian Xin , Yihong Cheng , Zhihong Lv , Wenjuan He , Miaoqin Tan , Meiqi Lin , Shuqiong Zheng , Junlong Guo , Bin Zhang","doi":"10.1016/j.jpsychires.2025.03.014","DOIUrl":"10.1016/j.jpsychires.2025.03.014","url":null,"abstract":"<div><h3>Objective</h3><div>The neuroelectrophysiology mechanisms of the connection between nonsuicidal self-injury (NSSI) and impairment of social decision-making function remain unknown. As the event-related potentials (ERPs) technique has been widely used in neurobiology research because of its advantage of high temporal resolution, we conducted this study to explore the ERPs of decision-making function among adolescents with NSSI.</div></div><div><h3>Method</h3><div>This study was designed to compare patients with mood disorder plus NSSI with mood disorder patients without NSSI using a 2:1 ratio. Participants aged 12–18 years were recruited from the outpatient department of psychiatry at Nanfang Hospital. Sociodemographic and psychological data were collected. The Ultimatum Game, a task examining individuals' social decision-making, was conducted with the ERP technique to record participants’ neural responses. The associations between ERPs characteristics and psychological factors were examined by using correlation analysis and regression analysis.</div></div><div><h3>Results</h3><div>In total, 90 participants were eligible, with 60 in the NSSI group and 30 in the non-NSSI group. N1 latency in the unfair condition was positively correlated with Difficulties in Emotion Regulation Scale scores (r = 0.257), whereas P2 latency in the fair condition was correlated with agreeableness personality (r = 0.250). Regression analysis revealed that N1 latency in the unfair condition was positively associated with NSSI (ORs ranged 1.07–1.10), whereas P2 latency in the fair condition was negatively associated (ORs ranged 0.95–0.97).</div></div><div><h3>Conclusion</h3><div>NSSI patients tended to exhibit impairment in decision-making function including initial cognitive value judgment, attentional allocation, and working memory process. ERPs characteristics including N1 latency and P2 latency may be predictors of NSSI.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 350-358"},"PeriodicalIF":3.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chia-Shin Guo , Doreen Phiri , Hsin-Chien Lee , Yen-Kuang Lin , Jimmy Alvin Metrado Kwa , Min-Huey Chung
{"title":"Effect of bright light therapy on depression in patients with schizophrenia: A pilot study","authors":"Chia-Shin Guo , Doreen Phiri , Hsin-Chien Lee , Yen-Kuang Lin , Jimmy Alvin Metrado Kwa , Min-Huey Chung","doi":"10.1016/j.jpsychires.2025.02.050","DOIUrl":"10.1016/j.jpsychires.2025.02.050","url":null,"abstract":"<div><h3>Objective</h3><div>In this pilot study, we investigated the effects of bright light therapy on depression in schizophrenia using a quasi-experimental design involving random assignment.</div></div><div><h3>Methods</h3><div>We included patients with schizophrenia who had stable psychiatric symptoms. Experimental group (n = 16) received light therapy while control group (n = 12) received only regular indoor light. The intervention was administered in the morning once a day for 50 min for three weeks. Scores of the Chinese version of the Calgary Depression Scale for Schizophrenia (CDSS-C), Chinese version of the Positive and Negative Syndrome Scale (PANSS-C), Clinical Global Impression-Schizophrenia Scale (CGI-SCH), and Stressful Life Event Scale (SLES) were measured at baseline (T0), immediately after 5th day of the intervention (T1), immediately after the 15th day of intervention (T2), and at the 14-day follow-up (T3). A generalized estimating equation (GEE) analysis was performed to analyse group × time interaction effects and effect of bright light therapy on depression.</div></div><div><h3>Results</h3><div>Results indicated that bright light therapy alleviated depressive symptoms in patients with schizophrenia after controlling for internal or surgical diseases and disease duration (in years). However, the effect was not maintained two weeks after the treatment.</div></div><div><h3>Conclusion</h3><div>These findings suggest that bright light therapy is a nonpharmacological adjunct treatment approach for patients with stable psychiatric symptoms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 325-332"},"PeriodicalIF":3.7,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ulla Knorr , Anja Hviid Simonsen , Johanna Nilsson , Ann Brinkmalm , Henrik Zetterberg , Kaj Blennow , Mark Bech Knudsen , Julie Forman , Kamilla Woznica Miskowiak , Steen Gregers Hasselbalch , Lars Vedel Kessing
{"title":"Associations between cerebrospinal fluid synaptic protein biomarkers and cognitive function in bipolar disorder","authors":"Ulla Knorr , Anja Hviid Simonsen , Johanna Nilsson , Ann Brinkmalm , Henrik Zetterberg , Kaj Blennow , Mark Bech Knudsen , Julie Forman , Kamilla Woznica Miskowiak , Steen Gregers Hasselbalch , Lars Vedel Kessing","doi":"10.1016/j.jpsychires.2025.03.005","DOIUrl":"10.1016/j.jpsychires.2025.03.005","url":null,"abstract":"<div><div>This study is the first to investigate the association between a comprehensive panel of cerebrospinal fluid (CSF) synaptic protein biomarkers and cognitive function using data from a prospective cohort study including N = 59 patients with bipolar disorder (BD) in remission and N = 37 healthy control individuals (HC). The CSF synaptic protein biomarkers included neuronal pentraxin (NPTX)1, NPTX2, 14-3-3 proteins, AP-2 complex subunit-beta, beta-synuclein, complexin-2, gamma-synuclein, NPTX-receptor, phosphatidylethanolamine-binding proteins, rab GDP dissociation inhibitor-alpha, syntaxins-1B and 7. The biomarkers of synaptic dysfunction were analyzed by targeted mass spectrometry. The primary cognition measure was a global cognitive composite score based on neuropsychological tests of verbal learning and memory, executive function, psychomotor speed, and sustained attention. Our primary hypothesis was that levels of NPTX1 and NPTX2 were associated with global cognition and verbal memory. The study revealed consistent positive associations between CSF concentrations of NPTX1 and NPTX2 and global cognitive function. However, only the association with a tryptic peptide from NPTX2 (VAELEDEK) remained statistically significant after adjustment for multiple tests. No consistent trends or significant relationships were found between NPTX1 and NPTX2 and verbal memory. NPTXs showed positive associations with sustained attention, and the NPTX receptor was positively associated with global cognition scores. Similar trends were found in BD patients and HC individuals. The study provides novel evidence for a potentially pivotal role of CSF synaptic proteins, particularly NPTX1, NPTX2, and NPTX-receptor, in shaping global cognitive function across BD and HC populations and increases our understanding of the neurobiological foundations for cognitive functions across diagnostic boundaries.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 288-296"},"PeriodicalIF":3.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maja Brydevall , Lucy Albertella , Erynn Christensen , Chao Suo , Murat Yücel , Rico S.C. Lee
{"title":"The role of psychological distress in understanding the relationship between habitual decision-making and addictive behaviors","authors":"Maja Brydevall , Lucy Albertella , Erynn Christensen , Chao Suo , Murat Yücel , Rico S.C. Lee","doi":"10.1016/j.jpsychires.2025.03.004","DOIUrl":"10.1016/j.jpsychires.2025.03.004","url":null,"abstract":"<div><div>Existing models are currently inadequate in explaining the relationship between habitual decision-making and different expressions of addictive behaviors. The current study investigates the role of psychological distress as a key factor in disrupting decision-making processes in the context of substance and behavioral addictions. A large community sample (N = 668) completed a gamified two-stage task to investigate the link between model-free (habitual) task behavior and a wide range of addictive behaviors. Addictive behaviors included substance use (alcohol, nicotine, and illicit drug use) and behavioral addictions (problematic use of the internet, addictive eating, shopping, and gambling). The relationship between habitual task behavior and addictive engagement was investigated using structural equation modelling with a bifactor latent variable structure, which was modeled and tested; one for substance use and one for behavioral addictions. For participants with higher levels of psychological distress, greater habitual task behavior was a significant predictor of behavioral addiction risk (<em>β</em> = −0.188, <em>SE</em> = 2.061, <em>p</em> = .016), specifically problematic use of the internet (<em>β</em> = −0.148, <em>SE</em> = 0.045, <em>p</em> = .018) and eating behaviors (<em>β</em> = −0.191, <em>SE</em> = 0.016, <em>p</em> < .001). These findings support our proposition that psychological distress disrupts cognitive control, leading to a greater reliance on habitual decision-making and non-substance addictive behaviors. This highlights the potential importance of habit-based interventions in combination with stress-reduction and mental health-promoting techniques to improve outcomes and minimize harm, especially in the context of behavioral addictions.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 297-306"},"PeriodicalIF":3.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Romina Isabel Álvarez Casiani , Leandro Nicolás Grendas , Alejandro Olaviaga , Luciana Carla Chiapella , Ángeles Romina Arena , Vera Tifner , Cintia Romina Prokopez , Jhon Esteban López-Carvajal , Josefina Robetto , Eugenio Antonio Carrera Silva , Andrea Emilse Errasti , Federico Manuel Daray
{"title":"Monocyte profiles and their association with depression severity and functional disability","authors":"Romina Isabel Álvarez Casiani , Leandro Nicolás Grendas , Alejandro Olaviaga , Luciana Carla Chiapella , Ángeles Romina Arena , Vera Tifner , Cintia Romina Prokopez , Jhon Esteban López-Carvajal , Josefina Robetto , Eugenio Antonio Carrera Silva , Andrea Emilse Errasti , Federico Manuel Daray","doi":"10.1016/j.jpsychires.2025.03.008","DOIUrl":"10.1016/j.jpsychires.2025.03.008","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory processes have been implicated in the pathophysiology of depression. This study explores the association between the number, proportion and subtypes of monocytes with functional disability and depression severity in a sample of adult patients.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted with 74 participants. The total number and proportion of monocytes were obtained from hemogram analysis and the subtypes (classical, intermediate, and non-classical) were quantified using flow cytometry. Depression severity was assessed using the 17-item Hamilton Depression Rating Scale (HDRS-17), and functional disability was measured via the Sheehan Disability Scale (SDS). Linear regression models adjusted for demographic and clinical covariates were applied to evaluate associations.</div></div><div><h3>Results</h3><div>Total blood monocyte counts and their percentages were negatively correlated with functional disability scores (r = −0.27 and r = −0.26, respectively; p < 0.05). In contrast, elevated levels of intermediate and non-classical proinflammatory monocytes were positively correlated with depression severity (r = 0.25, p < 0.05). Linear regression analysis revealed that a 1% increase in proinflammatory monocytes was associated with a 0.19-point increase in HDRS-17 scores (p = 0.009). Additionally, higher total and percentage monocyte counts were associated with reductions in functional disability scores by 10.63 units (p = 0.02) and 0.80 units (p = 0.04), respectively.</div></div><div><h3>Conclusion</h3><div>Monocytes play a dual role, contributing to both the initiation and resolution of inflammation. In this study, we found that monocytes may be involved in protecting functional responses while also reflecting depression severity. These findings underscore the potential of monocyte profiles as biomarkers for depression severity and functional impairment, highlighting the need for further research to elucidate the underlying mechanisms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 272-278"},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristian Elersič , Anamarija Banjac, Marko Živin, Maja Zorović
{"title":"Increased sensitivity to psychomotor effects of ketamine enantiomers in the Wistar-Kyoto depression model","authors":"Kristian Elersič , Anamarija Banjac, Marko Živin, Maja Zorović","doi":"10.1016/j.jpsychires.2025.02.061","DOIUrl":"10.1016/j.jpsychires.2025.02.061","url":null,"abstract":"<div><div>Ketamine, a fast-acting antidepressant, is a racemic mixture, composed of equal amounts of R- and S-ketamine. Preclinical studies are comparing them to better understand their role in therapeutic and undesirable effects. An important research gap is that studies do not use long clinically relevant protocols to compare the desired and undesired effects of ketamine enantiomers in modeled and control animals. In our preclinical study, we explored the behavioral effects of R- and S-ketamine at 10 mg/kg in clinically relevant treatment protocol using Wistar-Kyoto rats as a depression model and Wistar rats as a control. Undesirable psychomotor effects were evaluated with locomotor stimulation and sensitization, ataxia, and stereotypy. Persistent effects associated with therapeutic outcomes were evaluated by measuring working memory, anxiety, and behavioral despair. We found that S-ketamine has stronger acute psychomotor effects compared to R-ketamine and that Wistar-Kyoto rats are more sensitive to these effects compared to Wistar rats. After repeated treatment, sensitization to locomotor stimulating effects, and tolerance to ataxic effects of S-ketamine develops. We found no persistent changes due to ketamine treatments. Taken together, our results may indicate that depressed patients would be more prone to negative side effects of ketamine, compared to healthy controls. However, after repeated treatment, tolerance to side effects may develop and make the treatment more tolerable. Future preclinical and clinical studies are needed to address neurobiological mechanisms and clinical relevance of higher sensitivity to the psychomotor effects of ketamine, and the development of tolerance to psychomotor effects of ketamine in depressed individuals.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 307-317"},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katharina Kerkel , Stefan Schoisswohl , Berthold Langguth , Mohamed A. Abdelnaim , Jost Bernet , Martin Schecklmann , Andreas Reissmann
{"title":"Is more better? Comparing 600, 1200 and 1800 pulses/session (p/s) of intermittent theta-burst stimulation (iTBS) for the treatment of depression","authors":"Katharina Kerkel , Stefan Schoisswohl , Berthold Langguth , Mohamed A. Abdelnaim , Jost Bernet , Martin Schecklmann , Andreas Reissmann","doi":"10.1016/j.jpsychires.2025.03.006","DOIUrl":"10.1016/j.jpsychires.2025.03.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Repetitive Transcranial magnetic stimulation (rTMS) is a non-invasive therapy for treatment-resistant disorders. Intermittent theta-burst stimulation (iTBS) has emerged as a favorite treatment protocol for the treatment of therapy resistant depression, with the tendency to administer an increasing number of pulses/session (p/s).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed the records of 215 in- and out-patients, suffering from unipolar or bipolar depressive disorder in a German tertiary care hospital between January 2021 and September 2024. All patients received left prefrontal iTBS with either 600 (<em>n</em> = 68), 1200 (<em>n</em> = 67) or 1800 (<em>n</em> = 80) p/s over the course of 15–20 days. Depressive symptoms were assessed with the 21-item Hamilton Depression Rating Scale (HAMD-21) and the Major Depression Inventory (MDI) before and at the end of the respective treatment. Side effects were quantified by the number of patients reporting a side effect in at least one of the rTMS sessions.</div></div><div><h3>Results</h3><div>In all groups, the HAMD-21 and MDI scores improved significantly. There was no significant difference between the three groups (HAMD-21: <em>p</em> = .198, MDI: <em>p</em> = .281). Further, this result equally applies to men and women (all <em>p</em>′s > .145). No serious side effects occurred. Patients who were treated with 600 p/s reported most side effects.</div></div><div><h3>Conclusion</h3><div>Our retrospective analysis suggests that an increase of p/s from 600 to 1200 or 1800 does not result in more pronounced antidepressant effects.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 256-261"},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zakia Aura Fajriana , Riangga Novrianto , Nimaz Indryastuti Dewantary , Pelita DKL. Tobing , Eric A. Storch , Edo S. Jaya
{"title":"Understanding depression and anxiety symptom interrelations in Indonesian OCD patients: A network approach","authors":"Zakia Aura Fajriana , Riangga Novrianto , Nimaz Indryastuti Dewantary , Pelita DKL. Tobing , Eric A. Storch , Edo S. Jaya","doi":"10.1016/j.jpsychires.2025.03.007","DOIUrl":"10.1016/j.jpsychires.2025.03.007","url":null,"abstract":"<div><div>Obsessive-compulsive disorder (OCD) patients often experience co-occurring symptoms of depression and anxiety, underscoring the needs for targeted clinical interventions that address overlapping symptoms. Network analysis offers a method to examine the symptom interrelations and identify key symptoms for OCD patients interventions. This study collected self-report data on depression (PHQ-9) and anxiety (GAD-7) on OCD-diagnosed outpatients from a clinical psychology clinic in Jakarta, Indonesia (N = 232). The data were analyzed with several network analysis methods, including association networks, graphical LASSO, and directed acyclic graphs (DAGs), to visualize symptom interrelations. The findings indicated that while depression and anxiety symptoms in OCD are distinct, they are linked by “bridge” symptoms. Specifically, motor symptoms of depression and restlessness symptoms of anxiety were the key bridges, with worry and nervousness identified as highly central anxiety symptoms. In contrast, symptoms like appetite and suicidal symptoms of depression, along with irritability and fear in anxiety, were less connected within the network. Network analysis highlights that motoric symptoms may play a critical role in maintaining co-occurring anxiety and depression in OCD patients. Thus, interventions targeting motoric symptoms—such as intense exercise and behavioral activation—could be beneficial for managing these interconnected symptoms and improving patient outcomes.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 359-366"},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gianluca Saetta , Yannik Peter , Kathy Ruddy , Jasmine T. Ho , Roger Luechinger , Emily Cross , Lars Michels , Bigna Lenggenhager
{"title":"Feeling at home in a virtually amputated body; neural and phenomenological effects of illusory embodiment in body integrity dysphoria","authors":"Gianluca Saetta , Yannik Peter , Kathy Ruddy , Jasmine T. Ho , Roger Luechinger , Emily Cross , Lars Michels , Bigna Lenggenhager","doi":"10.1016/j.jpsychires.2025.02.055","DOIUrl":"10.1016/j.jpsychires.2025.02.055","url":null,"abstract":"<div><div>In Body Integrity Dysphoria (BID) a profound incongruity between the physical body and the desired, i.e., amputated body, often leads to a desire for limb amputation. Virtual reality (VR) and multisensory stimulation paradigms provide powerful tools to create the experience of being embodied in an amputated body.</div><div>Here we investigate the impact of such an experience on neural and subjective responses in 18 individuals with BID and 18 controls. We used both task-based and resting-state MRI before and after participants played an immersive virtual game in an amputated body corresponding to their desired bodily shape and mimicking their movements. The task-based fMRI assessed neural activity when viewing images of the body in the desired versus the undesired state.</div><div>Individuals with BID reported higher sense of ownership and control over the virtual body. Task-based fMRI showed increased pre-VR activity in the right superior parietal lobule (rSPL), right angular gyrus, and right supplementary motor area in the BID group, normalizing after VR exposure. Resting-state fMRI showed reduced connectivity in the rSPL, visuo-occipital areas, fronto-parietal, and fronto-striatal mirror and limb system networks, also normalizing post-VR. Additionally, there was a normalization in the pattern of increased connectivity of cortico-striatal tracts connecting the rSPL and the pars orbitalis of the right inferior frontal gyrus with the nucleus accumbens.</div><div>Our findings suggest that virtual embodiment effectively modulates BID-related neural networks, offering a safe, cost-effective intervention for BID and highlights VR's potential in exploring the complex interaction between body and self, with potential implications for similar psychiatric conditions.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Pages 395-404"},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}