Journal of psychiatric research最新文献

{"title":"Stepwise interventional psychiatry approach for major depression: A case series","authors":"Véronique Desbeaumes Jodoin ,&nbsp;Emma Bousseau ,&nbsp;François Trottier-Duclos ,&nbsp;André Do ,&nbsp;Nicolas Garel ,&nbsp;Laurent Elkrief ,&nbsp;Paul Lespérance ,&nbsp;Jean-Philippe Miron","doi":"10.1016/j.jpsychires.2025.09.060","DOIUrl":"10.1016/j.jpsychires.2025.09.060","url":null,"abstract":"<div><h3>Introduction</h3><div>Many patients with treatment-resistant depression (TRD) require multiple interventions to achieve symptom relief. We explored outcomes from a stepwise, real-world protocol combining transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and intravenous ketamine.</div></div><div><h3>Methods</h3><div>Twenty-eight adults with major depressive disorder were initially treated with a 50-session spaced tDCS protocol. Non-responders were sequentially offered rTMS (30 sessions of iTBS), followed by intravenous racemic ketamine (6 infusions) if needed. Response was defined as ≥50 % reduction in MADRS scores.</div></div><div><h3>Results</h3><div>Following tDCS, 46.4 % (13/28) of patients achieved response and 32.1 % achieved remission. Of 11 patients who proceeded to rTMS, 36.4 % (4/11) responded. Among the four who received ketamine, 50 % (2/4) responded. The cumulative response and remission rates were 67.9 % and 53.6 %, respectively. Exploratory analyses revealed no significant baseline differences between responders and non-responders.</div></div><div><h3>Conclusions</h3><div>This case series suggests that a sequential neuromodulation strategy may increase overall response rates in TRD by capturing different responder profiles across modalities. These findings support the feasibility of a pragmatic stepwise approach and highlight the need for controlled studies to guide personalized sequencing strategies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 177-179"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different doses of glucocorticoids on postoperative neurocognitive function and mood disorders: A systematic Review and network meta-analysis","authors":"Yingying Fan ,&nbsp;Jiaqi Li ,&nbsp;Ruoyu Luo ,&nbsp;Liwen Hao ,&nbsp;Chaoyun Yuan ,&nbsp;Jiyong Jing","doi":"10.1016/j.jpsychires.2025.09.050","DOIUrl":"10.1016/j.jpsychires.2025.09.050","url":null,"abstract":"<div><h3>Background</h3><div>Perioperative Neurocognitive Disorder and mood disorders have emerged as significant concerns impacting the quality of postoperative recovery. Ongoing research is focused on identifying pharmacological interventions to prevent postoperative PND and mood disorders. Glucocorticoids are extensively employed during the perioperative period; however, their effects on neurocognitive and psychological functions remain a matter of debate.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search of PubMed, Cochrane Library, EMBASE, and Web of Science from their inception to December 30, 2024, focusing on the use of various doses of corticosteroids during the perioperative period.</div></div><div><h3>Results</h3><div>A total of 25 studies, encompassing 17,378 patients, were included in the analysis. The administration of glucocorticoids significantly reduced the incidence of postoperative delirium (RR = 0.85, 95 %CI = 0.77 to 0.95, P = 0.002, I² = 41.5 %). Additionally, it decreased the severity of delirium (SMD = −0.66, 95 %CI = −0.84 to −0.48, P &lt; 0.01, I² = 92 %). The use of GCs (RR = 0.86, 95 %CI = 0.71 to 1.05, P = 0.132, I² = 25.2 %) did not significantly reduce the occurrence of mood disorders. In the high-dose group, GCs significantly lowered the incidence of delirium (RR = 0.79, 95 %CI = 0.63 to 0.99). Meanwhile, medium-dose GCs notably reduced the incidence of postoperative cognitive dysfunction (RR = 0.70, 95 %CI = 0.37 to 1.35) (RR = 0.58, 95 %CI = 0.36 to 0.92).</div></div><div><h3>Conclusion</h3><div>The use of glucocorticoids during the perioperative period significantly reduced the incidence and severity of postoperative delirium. The effects of different doses of glucocorticoids on postoperative neurocognitive and psychological status varied. The perioperative administration of medium-dose glucocorticoids appears to be safer and has the potential to prevent postoperative neurocognitive dysfunction.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 206-215"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of acute sleep deprivation and recovery sleep on cognitive performance in depressed individuals","authors":"Olivia Larson ,&nbsp;Mathias Basner ,&nbsp;Hengyi Rao ,&nbsp;Holly Barilla ,&nbsp;Elaine M. Boland ,&nbsp;Jennifer R. Goldschmied ,&nbsp;Christopher W. Jones ,&nbsp;Yvette I. Sheline ,&nbsp;John A. Detre ,&nbsp;Michael E. Thase ,&nbsp;Philip R. Gehrman","doi":"10.1016/j.jpsychires.2025.09.062","DOIUrl":"10.1016/j.jpsychires.2025.09.062","url":null,"abstract":"<div><div>Acute sleep deprivation (SD) can lead to rapid albeit transient antidepressant effects for some individuals with clinical depression. However, SD also has adverse effects on cognitive performance. As investigations into the mechanisms underlying the antidepressant effects of SD take place, it will also be important to fully characterize effects on other aspects of mental function. Here, we investigated relationships between depression and performance on a battery = assessing a range of cognitive domains at baseline, during acute SD, and after recovery sleep. Thirty-six individuals with current depression and 10 euthymic controls underwent a baseline night of sleep followed by 36 h of total SD and one night of recovery sleep in the laboratory. Participants completed the Cognition battery and a self-report survey of wellbeing twice after each protocol night. Depressed individuals had similar – if not faster – performance on Cognition subtests relative to healthy controls at baseline and reported worse wellbeing. SD had pronounced effects on both speed and accuracy across Cognition subtests, with all participants becoming slower, less accurate, and less efficient overall; no differences between depressed and healthy controls were observed. Performance returned to pre-deprivation levels after recovery sleep. These results suggest that currently depressed individuals exhibit the same decrements in cognitive performance after acute SD as non-depressed individuals, which is a critical consideration for future research aimed at elucidating the mechanisms that underlie SD's antidepressant effects and potential therapeutic applications.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 198-205"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, motivation, psychological distress, and gender differences of problematic social media use among Chinese college students","authors":"Manyun Li ,&nbsp;Yuzhu Hao ,&nbsp;Yunfei Wang ,&nbsp;Richard Morris III ,&nbsp;Xuyi Wang ,&nbsp;Tieqiao Liu ,&nbsp;Shubao Chen ,&nbsp;Tania Moretta","doi":"10.1016/j.jpsychires.2025.09.056","DOIUrl":"10.1016/j.jpsychires.2025.09.056","url":null,"abstract":"<div><div>Problematic social media use (PSMU) presents a substantial public health concern due to its pervasive negative impacts. While psychological distress and specific social media use motives have been implicated as risk factors, prevalence rates and the nuanced role of gender have shown inconsistent findings globally. Crucially, these complex interrelationships between PSMU, use motives (i.e., coping, conformity, enhancement, and social), distress symptoms, and gender differences remain largely underexplored in Chinese college student populations. To address this, our anonymous, web-based, cross-sectional study recruited 788 Chinese college students (mean age = 20.92 ± 2.74 years, 23.52 % male) to examine PSMU prevalence and its associations with the aforementioned factors. We found that 26.6 % of participants met criteria for PSMU. Multiple regression analysis demonstrated that more severe PSMU was significantly associated with higher daily active and passive social media engagement, as well as elevated coping, conformity, and enhancement motives, and increased stress symptoms. Moreover, greater social media use for enhancement purposes was linked to PSMU only in women. These findings highlight coping motives, conformity motives, gender-specific enhancement motives, and psychological distress as potential critical influencing factors for PSMU, offering actionable targets for interventions.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 306-312"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced ventromedial prefrontal cortex volume and impaired attention associated with past suicide attempts in patients with mood disorders","authors":"Helena Andreu ,&nbsp;Kamilla Woznica Miskowiak ,&nbsp;Julian Macoveanu ,&nbsp;Lars Vedel Kessing ,&nbsp;Eduard Vieta ,&nbsp;Gitte Moos Knudsen ,&nbsp;Vibe G. Frokjaer ,&nbsp;Anjali Sankar","doi":"10.1016/j.jpsychires.2025.09.040","DOIUrl":"10.1016/j.jpsychires.2025.09.040","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD) are at heightened risk of suicidal behavior. Therefore, there is an urgent need for biomarkers to enable enhanced prevention approaches in high-risk individuals. Among potential biomarkers, brain structural measures and cognitive function are particularly promising.</div></div><div><h3>Objectives</h3><div>This study aims to replicate the role of ventromedial prefrontal cortex (vmPFC) in suicidal behavior across patients with mood disorders (MD) and to examine cognitive domains that may be impaired in this population.</div></div><div><h3>Methods</h3><div>Data on prior suicide attempts (SA) were obtained from the Danish Registers in a sample of 307 patients with MD who had magnetic resonance imaging (MRI) data (22 patients with MD and SA [MD_SA], 285 patients with MD and no SA [MD_NSA]) and an overlapping sample of 489 patients with neurocognitive assessments (31 MD_SA, 458 MD_NSA).</div></div><div><h3>Results</h3><div>MD_SA showed lower vmPFC volume compared to MD_NSA (p = 0.04). Secondarily, it was found that MD_SA show greater attention deficits in comparison with MD_NSA (p = 0.03), with no significant differences in the other neurocognitive functions.</div></div><div><h3>Conclusions</h3><div>Reduced vmPFC volume and deficits in attention may be associated with history of suicidal behaviors in patients with MD. These findings support previous research highlighting the role of vmPFC in suicidal behavior and suggest that there may be specific cognitive subdomains that are particularly affected, offering potential intervention targets for future evaluation.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 501-506"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of depression and suicide in adults with pre-existing primary headaches","authors":"Back Kim ,&nbsp;Sangwoo Park ,&nbsp;Su Kyoung Lee ,&nbsp;Hyun-Young Shin ,&nbsp;Kyae Hyung Kim ,&nbsp;Sun Jae Park ,&nbsp;Jihun Song ,&nbsp;Hye Jun Kim ,&nbsp;Jaewon Kim ,&nbsp;Hyeokjong Lee ,&nbsp;Seogsong Jeong ,&nbsp;Sang Min Park","doi":"10.1016/j.jpsychires.2025.09.052","DOIUrl":"10.1016/j.jpsychires.2025.09.052","url":null,"abstract":"<div><div>Primary headaches, particularly tension-type headaches (TTH) and migraine, are common and are associated with several comorbidities, including psychiatric conditions such as depression and suicide. However, there is limited evidence on the temporal relationship between primary headaches and subsequent depression and suicide, and most prior research has relied on self-reported data or cross-sectional designs. This population-based retrospective cohort study used data from the National Health Insurance Service-National Health Screening Cohort and involved 459,347 participants. Cox proportional hazards regression models were employed to compute adjusted hazard ratios (aHR) with 95 % confidence intervals (CI) for the risk of depression and suicide from 2006 to 2019 according to exposure to primary headaches from 2002 to 2005. Primary headaches were significantly associated with an elevated risk of depression (aHR for TTH = 1.55; 95 % CI = 1.49–1.62, aHR for migraine = 1.50; 95 % CI = 1.45–1.55) in both men and women. Tension-type headache was linked to a higher risk of suicide with statistical significance in men (aHR = 1.39; 95 % CI = 1.00–1.94), but not in women (aHR = 1.11; 95 % CI = 0.73–1.69). Migraine was not significantly associated with suicide (aHR = 1.16; 95 % CI = 0.91–1.46). Primary headaches are associated with an increased risk of depression in both men and women. Tension-type headache is related to an elevated risk of suicide in men. These findings highlight the need for comprehensive management of headache disorders that addresses both the physical and mental health aspects, not only in women but also in the male population.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 216-225"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal periconceptional exposure to reserpine and antidepressants causes developmental abnormalities and ADHD-like behavior in offspring: A deep learning analysis","authors":"Yehua Bao ,&nbsp;Yiwei Du ,&nbsp;Jiayi Zhang ,&nbsp;Meijuan Li ,&nbsp;Xiaoting Man ,&nbsp;Keju Gu ,&nbsp;Jie Li ,&nbsp;Xizeng Feng","doi":"10.1016/j.jpsychires.2025.09.039","DOIUrl":"10.1016/j.jpsychires.2025.09.039","url":null,"abstract":"<div><div>A growing body of research indicates that paternal exposure to adverse environments can result in genetic toxicity in the offspring. Nevertheless, the consequences of paternal preconception exposure to reserpine or antidepressant medications (venlafaxine alone, crocin alone, or a combination of venlafaxine and crocin) on offspring health remain uninvestigated. The present study elucidates the effects of paternal preconception in a depressed state or exposure to antidepressants on offspring development and motor behavior. In this study, a deep learning Twin Network was employed to accurately stage F1 generation embryos and objectively quantify the developmental tempo. EmbryoNet was employed to predict developmental abnormalities signals (<em>shh, nodal, bmp</em>) in the F1 generation embryos, those associated with the dopamine pathway. Furthermore, dopamine is linked to motor behavior. The behavioral results suggest the presence of ADHD-like behaviors in the F1 generation of paternally exposed reserpine. It is generally accepted that genotoxicity is usually accompanied by ROS production. In conclusion, the deep learning approach employed in this study allows for the early prediction of abnormal signals and early screening and diagnosis. This study makes a valuable contribution to the safety assessment of antidepressant drugs, providing a cautionary role for the intake of antidepressants and paternal inheritance.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 226-237"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT as therapy: A qualitative and network-based thematic profiling of shared experiences, attitudes, and beliefs on Reddit","authors":"Amanda C. Collins ,&nbsp;Damien Lekkas ,&nbsp;Michael V. Heinz ,&nbsp;Janelle Annor ,&nbsp;Franklin Ruan ,&nbsp;Nicholas C. Jacobson","doi":"10.1016/j.jpsychires.2025.09.057","DOIUrl":"10.1016/j.jpsychires.2025.09.057","url":null,"abstract":"<div><div>In recent years, large language models (LLMs), including ChatGPT, have exponentially grown in application. Given existing barriers to mental health services, alongside the capability of LLMs to generate therapeutic responses, LLMs have potential to serve as accessible precursors, adjuncts, or alternatives to traditional therapy. However, little is known about the opinions of persons who have used LLMs for mental health-related problems. Thus, the current work investigated the positive and negative experiences of those who have interacted with ChatGPT for their mental health using posts from relevant Reddit threads (<em>N</em> = 1594). A 33-item coding scheme was applied to code the presence/absence of each item, and coded posts were modeled using an Ising network graph to explore pairwise and groupwise thematic associations of items. Results from the qualitative coding indicated that the codes representing positive sentiment, experiencing affect/emotion, and attaining personal benefit from using ChatGPT for therapy were among the most frequently coded. Moreover, the Ising network model revealed the most important associations were between items representing positive experiences with ChatGPT (e.g., it performs better than a human therapist in some way and is empathetic), negative experiences (e.g., restrictions worsened their mental health), and specific pathologies (e.g., used it for both anxiety and stress). In addition, the node representing ChatGPT as functioning well as a therapist was the most central node in the network Taken together, the current study indicates that, while users endorse several benefits from using ChatGPT for their mental health, they also report significant drawbacks, including restrictions by ChatGPT that can harm them or exacerbate their symptoms. Thus, ChatGPT may be a useful tool for persons not able to receive standard care, but it may not be as beneficial for persons with more severe pathologies or mental health concerns.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 277-284"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal medicine for anxiety disorders and obsessive-compulsive disorder: A systematic review with meta-analysis","authors":"Yoann Birling ,&nbsp;Wing Yu Yu ,&nbsp;Rogier HJ. Hoenders ,&nbsp;Paul P. Fahey","doi":"10.1016/j.jpsychires.2025.09.045","DOIUrl":"10.1016/j.jpsychires.2025.09.045","url":null,"abstract":"<div><div>The objective of this systematic review is to assess the effectiveness and safety of Chinese Herbal Medicine (CHM) for anxiety disorders and obsessive-compulsive disorder (OCD). EMBase, PubMed, CINAHL, CNKI, Wanfang, CQVIP, <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> and Chinese Clinical Trial Registry were searched from database inception to January 2025 using search terms defining “anxiety/OCD”, “Chinese herbal medicine” and “randomized controlled trial”. From a total of 9805 reports screened, 92 randomised-controlled trials in which CHM was tested against anxiolytics in the treatment of anxiety disorders and OCD were included in the review. The sample size, mean and standard deviation at end-of-intervention (for continuous outcomes) and number of participants who experienced adverse events were collected for each arm. Compared to anxiolytic medication, CHM was more effective in reducing anxiety (Hamilton Anxiety Rating Scale Mean Difference = −1.50 points, 95 % CI -2.21 to −0.78, <em>p</em> &lt; 0.001) and produced fewer adverse events (Incidence Rate Ratio = 0.33, 95 % CI 0.24 to 0.45, <em>p</em> &lt; 0.001) in participants with generalised anxiety disorder. These results are supported by studies with a low risk of bias. No study with a low risk of bias tested CHM for panic disorders and OCD. This systematic review indicates a favourable risk/benefit profile of CHM compared with anxiolytic medication for GAD, and therefore CHM could be considered as an alternative to anxiolytics. Studies with a low risk of bias are required to assess the effectiveness of CHM for panic disorders, phobic disorders and OCD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 356-362"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep duration and its associations with depressive, anxiety, PTSD symptoms, and psychotic-like experiences in young people: a household-based epidemiological study in Hong Kong","authors":"Stephanie Ming Yin Wong ,&nbsp;Natalie Hei Ting Wong ,&nbsp;Yi Nam Suen ,&nbsp;Christy Lai Ming Hui ,&nbsp;Edwin Ho Ming Lee ,&nbsp;Sherry Kit Wa Chan ,&nbsp;Eric Yu Hai Chen","doi":"10.1016/j.jpsychires.2025.09.035","DOIUrl":"10.1016/j.jpsychires.2025.09.035","url":null,"abstract":"<div><div>Sleep deficiency is a major global health threat. While some studies have suggested a J-shaped relationship between sleep duration and adverse health outcomes, the influence of excessive sleep is often attributed to confounding factors, such as depression. It remains unclear whether insufficient and excessive sleep would be similarly or differentially associated with a transdiagnostic range of mental health problems in young people. We collected data from 3210 participants (15–25 years) from a household-based epidemiological youth study in Hong Kong. Using univariate and multivariable logistic regression models, we examined the associations of sleep duration with probable depression, anxiety, post-traumatic stress disorder, and psychotic-like experiences (PLEs), while accounting for an array of confounders. The youth population in Hong Kong reported a mean sleep duration of 7.5 h (SD = 1.6); 35.3% had insufficient sleep (&lt;7h) and 5.5% excessive sleep (≥10 h). After adjustments, insufficient sleep was associated with probable depression (aOR = 1.35, CI = 1.11–1.63) and anxiety (aOR = 1.22, CI = 1.02–1.47). Nonetheless, when selecting young people without physical illness or using psychiatric/sleeping medications, the adjusted associations remained only for probable depression (aOR = 1.43, CI = 1.12–1.83). The effects of insufficient sleep on PLEs were found only in the univariate model and not after adjustments for insomnia and frequent nightmares. No clear association was observed between excessive sleep and all four symptom dimensions. Insufficient sleep may be a simple-to-assess indicator of mental health risks in young people, particularly in terms of depressive symptomatology. Understanding the factors contributing to the lack of sleep and identifying feasible strategies to develop healthier sleep habits among young people will be crucial.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"191 ","pages":"Pages 409-416"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}