Journal of psychiatric research最新文献

{"title":"Brain network communication in remission: a comparative study of bipolar and unipolar depression","authors":"Haiyan Liu ,&nbsp;Yi Xia ,&nbsp;Lingling Hua ,&nbsp;Hao Sun ,&nbsp;Rui Yan ,&nbsp;Zhijian Yao ,&nbsp;Jiaolong Qin","doi":"10.1016/j.jpsychires.2025.03.057","DOIUrl":"10.1016/j.jpsychires.2025.03.057","url":null,"abstract":"<div><div>Distinguishing between unipolar depression (UD) and bipolar disorder (BD) during periods of remission presents a significant clinical challenge. To mitigate the potential confounding effects of depressive episodes, our study compares the white matter networks of individuals with UD and BD in remission, aiming to explore the differentiation between these two affective disorders. Our cohort included 69 individuals with remitted UD, 55 with remitted BD, and 78 healthy controls (HC). We employed diffusion tensor imaging (DTI) to assess the white matter (WM) network. Additionally, we utilized a comprehensive set of connectome and five communication models to characterize the alterations within the whole-brain WM network. Compared to HC, both UD and BD patients showed reduced connectivity in the frontal orbital region, with BD patients exhibiting a more pronounced decrease. BD patients demonstrated superior navigation ability and higher shortest path metric values in key brain region connections compared to UD. Conversely, UD patients showed greater diffusion efficiency in certain brain regions. Communicability and search information analyses revealed distinct patterns of connectivity between the two patient groups, with potential implications for emotion regulation and information processing. Our findings highlight distinct brain connectivity patterns in BD and UD during remission, suggesting that these patterns could serve as neuroimaging biomarkers for differentiating between the two disorders. The study provides insights into the enduring effects of mood disorders on brain connectivity and has potential clinical implications for diagnosis and treatment.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Shared and distinct alterations in brain morphology in children with ADHD and obesity: Reduced cortical surface area in ADHD and thickness in overweight/obesity” [J. Psychiatr. Res. 180 (2024) 103-112 JPSYCHIATRRES-D-24-01138R3]","authors":"Keri S. Rosch ,&nbsp;Gita Thapaliya ,&nbsp;Micah Plotkin ,&nbsp;Stewart H. Mostofsky ,&nbsp;Susan Carnell","doi":"10.1016/j.jpsychires.2025.02.011","DOIUrl":"10.1016/j.jpsychires.2025.02.011","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"184 ","pages":"Page 528"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“The captain wanted to stay with the sinking … (can't say boat)”: How hypomanic personality traits interfere with inhibitory control?","authors":"Martina Traykova ,&nbsp;Delphine Raucher-Chéné ,&nbsp;Jean-Baptiste Maranci ,&nbsp;Sarah Barrière ,&nbsp;Chrystel Besche-Richard ,&nbsp;Arthur Kaladjian","doi":"10.1016/j.jpsychires.2025.03.060","DOIUrl":"10.1016/j.jpsychires.2025.03.060","url":null,"abstract":"<div><div>Inhibitory control, the ability to suppress or countermand an action or thought, is notably impaired in patients with bipolar disorder. However, the specific characteristics of this impairment and whether deficits can manifest prior to a formal bipolar disorder diagnosis or among individuals with subsyndromal symptoms are relatively unknown. Here we test whether healthy individuals exhibiting a higher level of hypomanic personality traits respond more rapidly, albeit with weaker inhibitory control. We evaluated 83 native French speakers using the Hypomanic Personality Scale (HPS) and administered the Hayling Sentence Completion Test for response inhibition and the Stroop Test for interference control. We found negative correlations between the HPS score and both the response initiation and response inhibition times on the Hayling Sentence Completion Test, but the scores did not affect accuracy. Regarding the Stroop Test, we observed a significant positive correlation between the scores for hypomanic personality traits and the number of errors on the color-word condition. Our findings demonstrate that a high level of hypomanic personality traits correlates with faster reaction times on response inhibition tasks and higher error rates on interference tasks. This underlines the importance of distinguishing between inhibitory control concepts when examining the risks of bipolar disorder.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 9-15"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of non-invasive brain stimulation techniques to reduce anger and violence proneness: Results of a systematic review and meta-analysis","authors":"Ángel Romero-Martínez,&nbsp;Carolina Sarrate-Costa,&nbsp;Luis Moya-Albiol","doi":"10.1016/j.jpsychires.2025.03.058","DOIUrl":"10.1016/j.jpsychires.2025.03.058","url":null,"abstract":"<div><div>Since the 1990s, there has been a rise in the number of publications assessing the effects of applying non-invasive brain stimulation (NIBS) to treat patients with drug-resistant depression. This involves applying magnetic fields or electrical currents to the surface of the skull to influence the superficial neurons in the cerebral cortex. Due to the evidence regarding symptom reduction in these types of patients, such as irritability or hostility, there was a rise in the use of this technique to reduce negative mood, including anger state. This decrease in anger state could also help reduce other problems such as violence proneness. In this sense, the anger state of individuals who are prone to violence might be affected by interfering with the excitability of the prefrontal cortex (PFC), a key brain region responsible for behavioral regulation. Thus, we conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. After initially identifying 2426 sources, we eventually included a total of 69 publications for the systematic review, from which 45 were employed for the meta-analysis. Only a few of them highlighted a significant contribution of using NIBS techniques on different regions of the PFC to reduce anger state or violence when compared to participants receiving sham stimulation in normative and clinical samples. Furthermore, the comparison of effect sizes between groups that received real stimulation on several regions of the PFC and those that received sham stimulation did not reveal a significant difference in reducing anger state or violence. In addition, despite most of the conclusions being consistent, considerable heterogeneity existed across studies regarding certain PFC regions, which could be explained by the type of NIBS employed. Therefore, using superficial stimulation over the PFC as a general tool for reducing violence proneness should be approached with caution, except in specific cases.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":"Pages 211-225"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Trends and determinants of time spent in the emergency department among Australian hospital presenting self-harm cases” [J. Psychiatr. Res. 181 (2025) 365–372]","authors":"Swikar Poudel ,&nbsp;Sandro Sperandei ,&nbsp;Andrew Page ,&nbsp;Arianne Reis ,&nbsp;Yi Guo ,&nbsp;Sithum Munasinghe ,&nbsp;Kathryn Worne ,&nbsp;Rowena Saheb ,&nbsp;Vlasios Brakoulias","doi":"10.1016/j.jpsychires.2025.03.042","DOIUrl":"10.1016/j.jpsychires.2025.03.042","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Page 56"},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing efficacy of serotonergic, opioidergic, and glutamatergic drugs in gambling disorder: A pooled analysis of response trajectories versus placebo","authors":"Mauro Pettorruso ,&nbsp;Francesco Di Carlo ,&nbsp;Giorgio Di Lorenzo ,&nbsp;Carmine Gelormini ,&nbsp;Roberto Guidotti ,&nbsp;Giovanni Martinotti ,&nbsp;Jon E. Grant","doi":"10.1016/j.jpsychires.2025.03.056","DOIUrl":"10.1016/j.jpsychires.2025.03.056","url":null,"abstract":"<div><div>Various pharmacological treatments have been explored to alleviate the symptoms and clinical manifestations of gambling disorder (GD) by targeting different neurotransmitter systems. This study retrospectively analyzed subjects with GD treated with serotonergic drugs, opioid antagonist drugs, and glutamatergic drugs compared to placebo, through a pooled analysis of clinical trials conducted at the University of Chicago. The Gambling Symptom Assessment Scale (G-SAS) was employed as the outcome measure. Temporal uniformity was ensured by managing timepoints as follows: baseline, early (4–5 weeks), intermediate (6–8 weeks), and final (10–16 weeks) from the start of treatment.</div><div>A total of 253 treatment-seeking subjects were included, receiving either glutamatergic drugs (N-acetylcysteine, memantine), opioidergic drugs (naltrexone), serotonergic drugs (paroxetine, escitalopram), or placebo. Within-group analysis demonstrated significant improvement in GD symptoms across all treatment groups. When comparing interventions over time, glutamatergic drugs proved more effective than placebo from the early observation timepoint and onwards. Opioidergic drugs were more effective than placebo at the final observation timepoint, while serotonergic drugs showed no significant effect compared to placebo.</div><div>Our findings reveal distinct efficacy patterns among the pharmacological classes, likely due to their different mechanisms of action and the various aspects of GD phenomenology they address. The significant placebo effect observed aligns with previous studies, underscoring the complexity of treating GD. In conclusion, given the heterogeneous nature of GD, these results emphasize the necessity of identifying and precisely characterizing GD subtypes to facilitate more tailored treatment approaches.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 112-118"},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of physical activity in the prospective association between body mass index and depressive symptoms in mothers from the 2015 Pelotas (Brazil) Birth Cohort","authors":"Luciana Tornquist ,&nbsp;Debora Tornquist ,&nbsp;Inácio Crochemore-Silva ,&nbsp;Gregore Iven Mielke ,&nbsp;Mariângela Freitas da Silveira ,&nbsp;Pedro Curi Hallal ,&nbsp;Marlos Rodrigues Domingues","doi":"10.1016/j.jpsychires.2025.03.051","DOIUrl":"10.1016/j.jpsychires.2025.03.051","url":null,"abstract":"<div><div>Maternal obesity has been associated with postpartum depression and a protective role of physical activity is indicated. This study aims to examine the role of moderate and vigorous physical activity (MVPA) in the prospective association between body mass index (BMI) and depressive symptoms in a cohort of mothers. Depressive symptoms were assessed at 3 and 48 months postpartum using the Edinburgh Depression Scale. BMI was calculated from weight and height measurements at 24 months postpartum and self-reported pre-pregnancy weight. MVPA was measured by accelerometers at 12–16 weeks of pregnancy and 24 months postpartum. Accelerometry data were available for 1953 mothers in pregnancy and 2546 postpartum. BMI was not significantly associated with depressive symptoms. However, the relationship between pre-gestational BMI and depressive symptoms 3 months postpartum was moderated by MVPA (p = 0.04). Among mothers with low MVPA, the association between BMI and depressive symptoms was not significant. However, among those who performed ≥42 min of MPVA/day, the relationship became significant and inverse (β: −0.125; 95 %CI: −0.248; −0.001), with mothers with higher BMI and high MVPA having lower depressive symptom scores<strong>.</strong> In conclusion, MVPA performs a positive role in the association between BMI and depressive symptoms, reinforcing the importance of MVPA promotion among mothers.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 161-168"},"PeriodicalIF":3.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous activity and functional connectivity in patients with hoarding disorder comorbid with attention-deficit/hyperactive disorder","authors":"Hirofumi Tomiyama ,&nbsp;Keitaro Murayama ,&nbsp;Kenta Kato ,&nbsp;Akira Matsuo ,&nbsp;Nami Nishida ,&nbsp;Kou Matsukuma ,&nbsp;Makoto Kawahito ,&nbsp;Mingi Kang ,&nbsp;Kenta Sashikata ,&nbsp;Koji Yamashita ,&nbsp;Kazufumi Kikuchi ,&nbsp;Tatsuhiro Wada ,&nbsp;Osamu Togao ,&nbsp;Tomohiro Nakao","doi":"10.1016/j.jpsychires.2025.03.055","DOIUrl":"10.1016/j.jpsychires.2025.03.055","url":null,"abstract":"<div><div>Despite recent studies suggesting an important association of hoarder disorder (HD) and attention-deficit/hyperactive disorder (ADHD), no neuroimaging study has investigated the differences between patients with HD comorbid with ADHD and those without ADHD. This study investigated the regional spontaneous activity and functional connectivity in HD, focusing on the comorbidity with ADHD.</div><div>Resting-state functional magnetic resonance imaging (MRI) data were obtained from 24 patients with HD and 31 healthy individuals. We investigated the group differences using the fractional amplitude of low-frequency fluctuation (fALFF). The altered regions in the fALFF were used as seeds in a functional connectivity analysis where we conducted group comparisons among the three groups: healthy controls (HCs), HD with ADHD (HD +ADHD), and HD without ADHD (HD -ADHD).</div><div>Compared to HCs, patients with HD had a reduced fALFF in the right inferior frontal gyrus (IFG). Functional connectivity analysis revealed that patients with HD + ADHD had reduced functional connectivity between the IFG and dorsolateral prefrontal cortex (DLPFC) compared to HCs, while the HD -ADHD group was intermediate level between HD +ADHD and HCs groups.</div><div>In conclusion, patients with HD have altered spontaneous activity of the IFG. Additionally, patients with HD + ADHD had significantly reduced functional connectivity between the IFG and the DLPFC. Our findings suggest the potential need to distinguish between subgroups of HD+ADHD to identify novel neurobiological models of HD that could guide future therapeutic strategies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 98-104"},"PeriodicalIF":3.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of personality traits on daily functioning: A study on a group of help-seeking young adults","authors":"Chiara Rossi ,&nbsp;Lorenzo Antichi ,&nbsp;Francesca De Salve ,&nbsp;Marco Aldegheri ,&nbsp;Antonio Basilisca ,&nbsp;Sonia Facchetti ,&nbsp;Erika Riva ,&nbsp;Matteo Sala ,&nbsp;Paola Scovazzi ,&nbsp;Luca Micheletti ,&nbsp;Giorgio Bianconi ,&nbsp;Giovanna Valvassori Bolgè ,&nbsp;Osmano Oasi","doi":"10.1016/j.jpsychires.2025.03.049","DOIUrl":"10.1016/j.jpsychires.2025.03.049","url":null,"abstract":"<div><h3>Introduction</h3><div>Functional impairment is a common issue among patients with mental health disorders and first-episode psychosis who seek assistance from public mental health services designed for early intervention. These services often provide brief psychotherapeutic treatments to enhance social and professional functioning. However, the effectiveness of these brief interventions varies. Identifying risk factors for mental disorders, such as specific personality traits, could inform the development of more effective early intervention strategies. This study aims to identify significant personality traits as predictors of social and occupational functioning among help-seeking young adults at ASST Ovest Milanese public mental health services in Northern Italy.</div></div><div><h3>Methods</h3><div>Data were collected from 229 participants (82 males, 147 females) aged 18–27 (M = 24.13; SD = 2.21). Participants completed a socio-demographic questionnaire, the Personality Inventory for DSM-5, and the Social and Occupational Functioning Assessment Scale. Regression models, Random Forest, and Gradient Boosting Machines were conducted.</div></div><div><h3>Results</h3><div>The regression model with Detachment as the only predictor provided the best fit, indicating that higher levels of Detachment are significantly associated with lower social and occupational functioning (MSE = 112.38, adjusted R² = 0.1188, p &lt; 0.001). Including Negative Affectivity and Disinhibition in the model did not improve predictive power and introduced overfitting. Additionally, some socio-demographic factors were positively associated with better functioning.</div></div><div><h3>Conclusion</h3><div>Detachment is a primary predictor of social and occupational impairment. Interventions should prioritize addressing detachment-related traits and integrate educational and vocational support to enhance functioning. Implementing individualized therapies based on these risk factors could improve mental health outcomes and reduce costs for public clinical facilities.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 146-153"},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships between clinician adherence to guideline-recommended treatment and memory function in patients with schizophrenia","authors":"Yasushi Kawamata ,&nbsp;Kazutaka Ohi ,&nbsp;Satsuki Ito ,&nbsp;Naomi Hasegawa ,&nbsp;Yuka Yasuda ,&nbsp;Michiko Fujimoto ,&nbsp;Hidenaga Yamamori ,&nbsp;Kentaro Fukumoto ,&nbsp;Fumitoshi Kodaka ,&nbsp;Junya Matsumoto ,&nbsp;Norio Yasui-Furukori ,&nbsp;Ryota Hashimoto","doi":"10.1016/j.jpsychires.2025.03.054","DOIUrl":"10.1016/j.jpsychires.2025.03.054","url":null,"abstract":"<div><h3>Background</h3><div>Memory function impairment is severe in patients with schizophrenia, but improving memory function remains challenging. The use of benzodiazepines and anticholinergics, which are not recommended by pharmacological therapy guidelines for schizophrenia, has been associated with worsened cognitive function. However, it remains unclear whether better adherence by psychiatrists to pharmacological therapy guidelines for schizophrenia is associated with improved memory function. Therefore, we investigated the relationship between psychiatrists’ adherence and memory function in patients with schizophrenia.</div></div><div><h3>Methods</h3><div>To evaluate the associations between psychiatrists' adherence to pharmacological therapy guidelines and memory function, we utilized the Individual Fitness Score (IFS), which includes multiple quality indicators, to assess each psychiatrist's adherence to these guidelines in treating each patient. Memory function was measured using the Wechsler Memory Scale-Revised in a total of 351 patients, including 40 patients with treatment-resistant schizophrenia (TRS) and 311 patients with non-TRS.</div></div><div><h3>Results</h3><div>We found that psychiatrist adherence was significantly positively correlated with verbal memory (<em>β</em> = 0.145, <em>p</em> = 6.45 × 10⁻³), attention/concentration (<em>β</em> = 0.138, <em>p</em> = 0.010), and delayed recall (<em>β</em> = 0.167, <em>p</em> = 1.57 × 10⁻³) in all patients with schizophrenia. Additionally, a nominal positive correlation was observed with visual memory (<em>β</em> = 0.124, <em>p</em> = 0.019). In non-TRS patients, the adherence of psychiatrists was significantly positively correlated with delayed recall (<em>β</em> = 0.166, <em>p</em> = 3.17 × 10⁻³) and nominally positively correlated with verbal memory (<em>β</em> = 0.141, <em>p</em> = 0.013) and attention/concentration (<em>β</em> = 0.114, <em>p</em> = 0.044) functions. In contrast, no significant associations were observed between the psychiatrists’ adherence and any memory functions in patients with TRS.</div></div><div><h3>Conclusions</h3><div>These findings suggest that enhancing guideline education for psychiatrists might improve cognitive impairments in patients with schizophrenia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"185 ","pages":"Pages 169-176"},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}