Journal of psychiatric research最新文献

{"title":"Associations of eveningness with occupational outcomes in mental disorders: the Northern Finland Birth Cohort 1966","authors":"Tuomas Majuri ,&nbsp;Sanna Huikari ,&nbsp;Marko Korhonen","doi":"10.1016/j.jpsychires.2025.05.044","DOIUrl":"10.1016/j.jpsychires.2025.05.044","url":null,"abstract":"<div><h3>Background</h3><div>The impact of mental health and chronotype on occupational outcomes has been examined, most of the studies linking mental disorders and eveningness with unfavourable occupational outcomes. However, no previous studies have explored the significance of chronotype in income and labour market attachment among individuals with mental disorders.</div></div><div><h3>Method</h3><div>Utilizing the Northern Finland Birth Cohort 1966 with linkages to registers and questionnaire data, we compared income and labour market attachment until midlife among individuals with 1) morning or intermediate type (M/I-type) and no mental disorder (reference group), 2) evening type (E-type) and no mental disorder, 3) M/I-type and mental disorder, and 4) E-type and mental disorder by using cross-tabulations and regression analyses. We stratified our analysis by sex.</div></div><div><h3>Results</h3><div>Compared to the reference group, E-types with mental disorders had the lowest cumulative income irrespective of sex. Among females, E-types with mental disorders had the highest risk for poor labour market attachment when compared to the reference group (OR (95 % CI) 2.33 (1.30–4.16)). Among males, M/I-types with mental disorders had heightened odds for poor labour market attachment (OR (95 % CI) 2.25 (1.55–3.27)), whereas for E-types with mental disorders, the risk was slightly non-significant (OR (95 % CI) 2.13 (0.95–4.78)).</div></div><div><h3>Conclusion</h3><div>This study highlights the significance of chronotype in income and labour market attachment among individuals with mental disorders. From the perspectives of healthcare and employers, individual interventions to support work ability should be targeted at E-types with mental disorders, as eveningness may contribute to poorer occupational outcomes in this group.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 29-36"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal perinatal depressive disorders and the risk of attention deficit and hyperactivity disorder in offspring: A linked data study","authors":"Biruk Shalmeno Tusa ,&nbsp;Rosa Alati ,&nbsp;Kim Betts ,&nbsp;Getinet Ayano ,&nbsp;Berihun Dachew","doi":"10.1016/j.jpsychires.2025.05.058","DOIUrl":"10.1016/j.jpsychires.2025.05.058","url":null,"abstract":"<div><h3>Background</h3><div>This study examines the risk of Attention-Deficit/Hyperactivity Disorder (ADHD) in offspring of mothers with perinatal depressive disorders, considering direct and indirect pathways through adverse birth outcomes.</div></div><div><h3>Methods</h3><div>The study employed a retrospective cohort design, utilising administrative-linked health data from New South Wales. Maternal perinatal depressive disorders and offspring ADHD were identified using the International Classification of Diseases, Tenth Revision, Australian Modification (ICD-10-AM .) codes. A generalised linear model with a binomial distribution and log link function was used to estimate the direct association. Additionally, a mediation analysis was conducted to examine the mediating effects of low birth weight, low Apgar scores, and preterm birth on the association between maternal antenatal depressive disorder and offspring ADHD.</div></div><div><h3>Results</h3><div>After adjusting for confounders, offspring of mothers with antenatal, postnatal, and perinatal depressive disorders had 2.10 (95 % CI: 1.46–3.03), 1.80 (95 % CI: 1.11–2.92), and 2.16 (95 % CI: 1.57–2.97) times greater risk of ADHD, respectively. Preterm birth minimally mediated the relationship between antenatal depression and ADHD, accounting for only 0.73 % of the total effect, which was about 45 times smaller than the direct effect. Low birth weight and low Apgar scores did not mediate this relationship.</div></div><div><h3>Conclusion</h3><div>Our study revealed that maternal perinatal depressive disorders are associated with an increased risk of offspring ADHD, with very minimal or no mediating effects from adverse birth outcomes. Therefore, implementing early intervention strategies aimed at improving maternal mental health is crucial to reducing the risk of ADHD in children.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 169-175"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of treatment on the quality of life of patients with obsessive-compulsive disorder: systematic review and meta-analysis","authors":"Samara dos Santos-Ribeiro ,&nbsp;Gabriela B. de Menezes ,&nbsp;Maria E. Moreira-de-Oliveira ,&nbsp;Verônica Hühne ,&nbsp;Pedro P. Fortes ,&nbsp;Leonardo F. Fontenelle","doi":"10.1016/j.jpsychires.2025.05.036","DOIUrl":"10.1016/j.jpsychires.2025.05.036","url":null,"abstract":"<div><div>This systematic review and meta-analysis investigated whether treatments for obsessive-compulsive disorder (OCD) are associated not only with decreases in symptom severity but also with improvements in quality of life (QoL). A systematic search of PUBMED, PsycInfo, Scopus, Web of Science and ClinicalTrials databases was performed. The inclusion criteria involved RCTs that investigated adults diagnosed with OCD and incorporated evaluations of baseline and endpoint assessments for QoL and OCD symptom severity. The search found 3872 records, with 19 remaining after all screening process. Most of the studies investigated psychological interventions, categorizable into clusters of CBT-based treatments, interventions with meditation components, and augmentation strategies. This categorization was utilized to perform subgroup analysis. All subgroup interventions had a non-significant effect on QoL, except for CBT-based treatments, which demonstrated a statistically significant difference when compared to waiting lists. Regarding the effect of the interventions on the severity of OCD symptoms, the effect sizes were small for CBT-based treatments and medium for interventions with meditation components and augmentation strategies. The CBT-based treatments lead to some improvement in QoL of people with OCD (when compared to no treatment). Evidence suggested that treatments incorporating meditation components or augmentation treatments lead to improvements in OCD symptoms unparalleled by QoL improvement. Further studies are needed to assess pre- and post-intervention QoL measures for a more robust conclusion. This can facilitate the identification of more beneficial and effective treatments, both in reducing symptoms and improving QoL.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 19-28"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of probiotics, prebiotics, and synbiotics on depression and anxiety symptoms of patients with depression: A systematic review and meta-analysis","authors":"Reza Moshfeghinia ,&nbsp;Hossein Nemati ,&nbsp;Asal Ebrahimi ,&nbsp;Dorsa Shekouh ,&nbsp;Saeed Karami ,&nbsp;Mohammad Mirahmadi Eraghi ,&nbsp;Hoorad Mohagheghzadeh ,&nbsp;Jennifer Hunter ,&nbsp;Mehdi Pasalar","doi":"10.1016/j.jpsychires.2025.05.053","DOIUrl":"10.1016/j.jpsychires.2025.05.053","url":null,"abstract":"<div><h3>Introduction</h3><div>Depression is a prevalent mental health disorder with significant societal impact and treatment challenges. Recent research on the gut-brain axis has led to interest in probiotics, synbiotics, and prebiotics as potential therapeutic options for depression. This systematic review aims to evaluate their effects and provide evidence-based insights for future research and clinical practice.</div></div><div><h3>Methods</h3><div>Six digital databases (Scopus, PubMed, Web of Science, Cochrane, PsycINFO, and CINAHL complete) were examined for English-language records. Inclusion criteria involved studies assessing the impact of probiotics, prebiotics, and synbiotic on depression and anxiety in individuals with depression. The Cochrane Collaboration's instrument was employed to evaluate the risk of bias. For meta-analysis, random-effects model was favored, and statistical analysis was conducted using Stata software version 17.</div></div><div><h3>Results</h3><div>From initial 4407 studies 19 studies included in meta-analysis. A meta-analysis of 19 studies involving 1405 participants (882 cases and 523 controls) revealed a significant decrease in depression scores among patients receiving probiotics, prebiotics, or synbiotics compared to the control group (SMD: −1.76 [-2.42, −1.10]), despite high heterogeneity between studies (I²: 96.29 %). Similarly, analysis of seven studies with 481 participants (237 cases and 244 controls) showed a significant decrease in anxiety scores for those receiving these supplements (SMD: −1.60 [-2.83, −0.36]), with high heterogeneity between studies (I²: 96.90 %).</div></div><div><h3>Conclusion</h3><div>In conclusion, our meta-analysis indicates that probiotics, prebiotics, or synbiotics significantly reduce depression and anxiety symptoms in patients with depression. Future research should address heterogeneity in diagnosis and intervention types to better understand their efficacy.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 104-116"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic benefit versus epistemic risk: Need for empirical research in psychedelic epistemology","authors":"Lucas F. Borkel ,&nbsp;Jaime Rojas-Hernández ,&nbsp;Domingo J. Quintana-Hernández ,&nbsp;Luis Alberto Henríquez-Hernández","doi":"10.1016/j.jpsychires.2025.05.039","DOIUrl":"10.1016/j.jpsychires.2025.05.039","url":null,"abstract":"<div><div>This paper highlights the ethical and epistemic challenges posed by psychedelic therapy and vindicates the importance of epistemology in the clinical and psychotherapeutic setting. Despite their relative physiological and psychological safety, these substances can induce changes in the beliefs of those who use them, such as paranormal beliefs. To explain the changes in beliefs, we introduced the concept of epistemic criteria (i.e., the principles individuals use to validate and justify their beliefs) and hypothesized that psychedelics may alter beliefs by modifying epistemic criteria. Further research should be conducted to determine this potential and under-researched risk of psychedelic therapy.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 117-125"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic examination of off-target effects of antipsychotic medications associated with microbiome disruption and heightened bacterial infection risks","authors":"Francesca McDonagh ,&nbsp;Elaine K. Murray ,&nbsp;Brian Hallahan ,&nbsp;Georgios Miliotis","doi":"10.1016/j.jpsychires.2025.05.046","DOIUrl":"10.1016/j.jpsychires.2025.05.046","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review aims to critically evaluate the link between antipsychotic drugs and bacterial infection risk, emphasising antimicrobial properties of antipsychotics, and microbiome changes that might heighten susceptibility to bacterial infections.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted across PubMed, Scopus, and Google Scholar, up to March 2024. Peer-reviewed articles that investigated the relationship between antipsychotics, their antimicrobial effects, microbiome alterations, and bacterial infection risk were included. Data extracted included antipsychotic type, infection risks, patient demographics, and study methodologies. Risk-of-bias assessments were performed using tools such as the Newcastle-Ottawa Scale and the SYRCLE risk-of-bias tool.</div></div><div><h3>Results</h3><div>The review analysed twenty-six studies detailing antimicrobial properties of antipsychotics, four studies on antipsychotic-induced microbiome alterations, and thirty-one studies assessing bacterial infection risk associated with antipsychotics. First-generation antipsychotics were observed to have broad antimicrobial properties, whereas second-generation antipsychotics primarily affected commensal bacteria. At least four antipsychotics were observed to disrupt the gut microbiota. A heightened risk of infection was observed among psychiatric cohorts as well as off-label antipsychotics use, with clozapine linked to a substantial increase in respiratory infection risk.</div></div><div><h3>Discussion</h3><div>Although antipsychotics remain indispensable in psychiatric care, their association with an increased risk of bacterial infections underscores the need for judicious prescribing and vigilant monitoring. The review identifies significant knowledge gaps attributable to inconsistent research methodologies, small study cohorts, lack of controls, and focus on a limited range of antipsychotics. Further standardised research is essential to deepen our understanding of these associations and to inform improved prescribing practices and risk mitigation strategies.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 171-183"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and association between emotional and behavioral problems and gaming disorder in children and adolescents——Evidence from 201,906 participants","authors":"Jing-Hong Liang ,&nbsp;Aerziguli Kakaer ,&nbsp;Mei-ling Liu ,&nbsp;Jia-qi Chen ,&nbsp;Xiu-zhi Yang ,&nbsp;Zhuo-wen Wu ,&nbsp;Zheng-ge Jin ,&nbsp;Wen-xin Ge ,&nbsp;Ying-qi Pu ,&nbsp;Yu-shan Zhang ,&nbsp;Li-xin Hu ,&nbsp;Feng-hua Sun ,&nbsp;Wendy Yajun Huang ,&nbsp;Stephen H.S. Wong ,&nbsp;Ya-Jun Chen","doi":"10.1016/j.jpsychires.2025.05.057","DOIUrl":"10.1016/j.jpsychires.2025.05.057","url":null,"abstract":"<div><div>Existing evidence suggested a potential link between mental health problems in children and adolescents and an increased odds of developing gaming disorder (GD). However, the relationship between emotional and behavioral problems (EBP) and GD remains unknown. This cross-sectional study, involving a sample size of 201,906 students aged 6–18 years from Guangzhou city, aims to investigate this association. The assessment of GD was performed using the Gaming Disorder Test, while EBP was evaluated via parent-reported Strength and Difficulty Questionnaire. Statistical analyses, including multiple logistic regression, subgroup analyses, and sensitivity analyses, were employed to examine the association between EBP and GD. The prevalence rate of GD was 11.4 %, with higher rates observed among adolescents and boys. After adjusting for covariates, children and adolescents with border or abnormal levels of total difficulties, internalizing problems, externalizing problems, emotional symptoms, conduct problems, hyperactivity/inattention problems, and pro-social behaviors exhibited a significantly increased odds of developing GD. This study suggests that Chinese children and adolescents with EBP may be more vulnerable to developing GD. Further longitudinal researches are needed to better understand this association.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 243-251"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rumination as a within-person indirect pathway between daily negative life events and suicidal ideation in recently hospitalized adults","authors":"Gemma T. Wallace ,&nbsp;Melanie L. Bozzay ,&nbsp;Leslie A. Brick ,&nbsp;Ivan W. Miller ,&nbsp;Emily Mower Provost ,&nbsp;Heather T. Schatten","doi":"10.1016/j.jpsychires.2025.05.050","DOIUrl":"10.1016/j.jpsychires.2025.05.050","url":null,"abstract":"<div><div>Negative life events are often implicated as a near-term risk factor for suicidal ideation (SI); however ruminative processes may play a critical role in amplifying the distress following experiences of negative life events, ultimately leading to greater suicide risk. In the present work, we examined whether rumination indirectly impacted the association between negative events and SI intensity in a day-level ecological momentary assessment (EMA) study. Participants (<em>N</em> = 107; M_age = 35.9 years, 65% female, 81% white) completed an EMA protocol for 65 days following psychiatric hospitalization. We used dynamic structural equation modeling to test a day-level, within-persons model of direct and indirect effects between negative events, rumination, and SI intensity. After fitting the model across all people, we derived person-specific estimates to examine heterogeneity in the model parameters (i.e., while the indirect effect may be significant in the full sample, effect sizes may vary across individuals). Results indicated that the indirect effect of rumination was significant in the full sample (unstandardized estimate = 0.026) and represented 38.058% of the total effect. Moreover, results for the person-specific examination indicated that the indirect effect was present for nearly all participants who reported SI at any point in their EMA data. Thus, in addition to highlighting the critical role that rumination can play in SI, this study also highlights the value in conducting person-specific research to understand the complexity and heterogeneity of psychological processes involved in suicide risk.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 153-161"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is ketamine safe for individuals in higher level of care treatment for eating disorders? Analysis of safety of subanesthetic ketamine in 104 patients","authors":"Elizabeth Wassenaar ,&nbsp;Dan V. Blalock ,&nbsp;Alan Duffy ,&nbsp;Megan Riddle ,&nbsp;Howard Weeks ,&nbsp;Phil Mehler ,&nbsp;Renee D. Rienecke","doi":"10.1016/j.jpsychires.2025.05.055","DOIUrl":"10.1016/j.jpsychires.2025.05.055","url":null,"abstract":"<div><div>Eating disorders are among the most challenging and fatal mental illnesses and, due to the complication of medical instability caused by malnutrition or other disordered eating behaviors, pose unique treatment challenges for patients with co-occurring depression and mood disorders. Randomized control trials have demonstrated “rapid and robust antidepressant effects” of generic ketamine in individuals with treatment-resistant depression and bipolar depression. This paper assesses the medical safety of ketamine as a treatment for co-occurring treatment-resistant depression or bipolar depression in patients in higher levels of care for their eating disorders. A retrospective analysis was conducted on 104 patients receiving higher levels of care for their eating disorder and who had co-occurring treatment-resistant depression or bipolar disorder. Data on medical safety, particularly in the context of medical and nutritional instability, was collected and analyzed. The findings demonstrated that ketamine is a safe intervention for patients with eating disorders and co-occurring treatment-resistant depression or bipolar depression, even in cases where relative medical or nutritional instability was present due to disordered eating behaviors. This paper presents that ketamine can be used safely with medical monitoring in patents with co-occurring eating disorder and treatment-resistant depression or bipolar depression, despite the challenges posed by medical and nutritional instability in this patient population.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 52-56"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mismatch negativity deficits in schizophrenia and bipolar disorder","authors":"Lizhao Du ,&nbsp;Xiong Jiao ,&nbsp;Kai Shi ,&nbsp;Dongyan Mo ,&nbsp;Jie Zhou ,&nbsp;Yuan Shi ,&nbsp;Xiaoqing Zhang ,&nbsp;Zheng Zeng ,&nbsp;Han Li ,&nbsp;Dongxia Duan ,&nbsp;Shanbao Tong ,&nbsp;Junfeng Sun ,&nbsp;Donghong Cui","doi":"10.1016/j.jpsychires.2025.05.037","DOIUrl":"10.1016/j.jpsychires.2025.05.037","url":null,"abstract":"<div><h3>Objectives</h3><div>Numerous studies have demonstrated mismatch negativity (MMN) deficits in schizophrenia (SCZ), and growing evidence suggests similar deficits in bipolar disorder (BPD). However, no large-scale MMN study has been conducted on Chinese patients with SCZ and BPD. This study aims to validate the presence of MMN deficits in SCZ patients and assess whether BPD patients exhibit similar deficits, using a large-scale Chinese cohort.</div></div><div><h3>Methods</h3><div>MMN data, Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scores, and other clinical interview and assessment data were collected from participants (SCZ: n = 208; BPD: n = 144; healthy controls (HC): n = 324). Analysis of covariance (ANCOVA) was used to examine group differences in MMN amplitudes/areas, with age and gender as covariates. Additionally, correlation analyses were performed to explore the relationships between MMN amplitudes/areas and clinical assessments. To further investigate neural processing, event-related spectral perturbation (ERSP) and inter-trial phase coherence (ITC) analyses within the theta and alpha frequency bands were conducted for both standard and deviant stimuli in the duration MMN (dMMN) and frequency MMN (fMMN) paradigms.</div></div><div><h3>Results</h3><div>ANCOVA results for dMMN and fMMN amplitudes/areas, adjusted for age and gender, revealed significantly smaller MMN amplitudes in both SCZ and BPD groups compared to HC. Strong and significant correlations were observed between MMN mean amplitude and peak amplitude/area for both dMMN and fMMN. ERSP and ITC analyses showed that SCZ patients exhibited significantly reduced theta and alpha ITC and ERSP compared to HC. BPD patients also demonstrated reductions in these measures, though to a lesser extent. Negative correlations between MMN mean amplitude and both ERSP and ITC were found across all groups. In SCZ patients, the mean amplitude of dMMN was negatively correlated with RBANS scores.</div></div><div><h3>Conclusions</h3><div>Our results demonstrate MMN deficits in both SCZ and BPD patients within a large Chinese cohort. The ERSP and ITC analyses highlight the importance of theta and alpha oscillations in auditory processing and reveal distinct neural processing differences between clinical groups and HC.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"188 ","pages":"Pages 94-103"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}