Journal of psychiatric research最新文献

{"title":"Effects of volatile anaesthetics on incidence of postoperative depression and anxiety symptoms in elderly patients: A retrospective analysis of a prospective cohort study","authors":"Shaohua You ,&nbsp;Xinyu Hao ,&nbsp;Fuyang Cao ,&nbsp;Jingsheng Lou ,&nbsp;Jiangbei Cao ,&nbsp;Yanhong Liu ,&nbsp;Yongxin Guo ,&nbsp;Hao Li ,&nbsp;Ao Li ,&nbsp;Junmei Xu ,&nbsp;Qingping Wu ,&nbsp;Xiaoping Gu ,&nbsp;Yi Feng ,&nbsp;Yuming Peng ,&nbsp;Libin Ma ,&nbsp;Zhikang Zhou ,&nbsp;Ruiyu Wu ,&nbsp;Weidong Mi ,&nbsp;Li Tong","doi":"10.1016/j.jpsychires.2024.11.034","DOIUrl":"10.1016/j.jpsychires.2024.11.034","url":null,"abstract":"<div><div>Studies have suggested volatile anaesthetics may alleviate depression and anxiety symptoms in patients. However, there is a paucity of research in this area. We wanted to determine the association between volatile anaesthetics and depression/anxiety symptoms in elderly patients within 7 days after surgery. This study retrospectively analysed data from a prospective database of patients aged 65 and above who underwent non-cardiac, non-neurosurgical elective surgery in 19 tertiary hospitals across 10 provinces in China. The study period spanned from April 1, 2020 to April 30, 2022. Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic. Binary logistic regression analyses were conducted, and propensity score-matching (PSM) and subgroup analyses were also applied. A total of 7165 patients were included in the analysis. Among them, 4957 (69.18%) cases received volatile anaesthetics. The administration of volatile anaesthetics was associated with a lower rate of postoperative depression [22.76% vs. 27.26%, odds ratio (OR): 0.75, <em>P</em> &lt; 0.001], and reduced the incidence of postoperative anxiety (19.59% vs. 24.68%, OR: 0.78, <em>P</em> &lt; 0.001). The risk of postoperative depression (24.78% vs.27.93%, OR: 0.85, <em>P</em> = 0.035), and anxiety (21.45% vs. 25.92%, OR: 0.81, <em>P</em> = 0.006) were both significantly decreased in the volatile anaesthetics group in the PSM cohort. The results suggest that using volatile anaesthetics maybe associated with a reduction in the incidence of depression and anxiety in elderly patients during the early postoperative period.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 179-187"},"PeriodicalIF":3.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor cortex excitability in schizophrenia or depression and its modulation with prefrontal intermittent theta-burst stimulation","authors":"Elin Thörnblom ,&nbsp;Linda Steinholtz ,&nbsp;Jonas Persson ,&nbsp;Hans Axelson ,&nbsp;Robert Bodén","doi":"10.1016/j.jpsychires.2024.11.055","DOIUrl":"10.1016/j.jpsychires.2024.11.055","url":null,"abstract":"<div><div>Altered cortical excitability is reported in schizophrenia and depression, but findings are inconsistent. Prefrontal repetitive transcranial magnetic stimulation (TMS) induces short-term motor cortex excitability changes in healthy individuals, but its effect in schizophrenia and depression remains unexplored. Prefrontal intermittent theta burst stimulation (iTBS) improves negative symptoms in depression. Cortical excitability is a suggested biomarker for prefrontal iTBS response. We investigated if prefrontal iTBS affects motor cortex excitability in schizophrenia or depression. Secondary aims were to examine motor cortex excitability as a predictor of iTBS effect on negative symptoms in depression and to compare excitability between groups with schizophrenia, depression and healthy controls. TMS indices of cortical excitability − resting motor threshold, short-interval intracortical inhibition, intracortical facilitation and long-interval intracortical inhibition (LICI) − were pooled from previous studies, including an RCT evaluating iTBS for negative symptoms. The dataset comprised 44 patients with schizophrenia, 52 with depression, and 62 healthy controls. Regression models indicated no effect of active versus sham iTBS on any TMS index (all <em>p</em> ≥ .61). No baseline TMS index predicted negative symptom changes after iTBS in depression (all <em>p</em> ≥ .44). Patients with schizophrenia exhibited more pronounced LICI inhibition than the other groups (Mann-Whitney <em>U</em> = 1670, <em>p</em> &lt; .001). LICI correlated with antipsychotic dose (Spearman's <em>ρ</em> = −0.28, <em>p</em> = .04). Prefrontal iTBS does not modify cortical excitability in schizophrenia or depression, nor does cortical excitability predict prefrontal iTBS effects on negative symptoms. The more pronounced LICI inhibition in schizophrenia may be related to the illness or medication.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 99-107"},"PeriodicalIF":3.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic features of inflammatory markers and executive function across psychiatric disorders","authors":"Tzu-Yun Wang ,&nbsp;Yun-Hsuan Chang ,&nbsp;Sheng-Yu Lee ,&nbsp;Hui Hua Chang ,&nbsp;Tsung-Yu Tsai ,&nbsp;Huai-Hsuan Tseng ,&nbsp;Shao-Ming Wang ,&nbsp;Po See Chen ,&nbsp;Kao Chin Chen ,&nbsp;I Hui Lee ,&nbsp;Yen Kuang Yang ,&nbsp;Jau-Shyong Hong ,&nbsp;Ru-Band Lu","doi":"10.1016/j.jpsychires.2024.11.037","DOIUrl":"10.1016/j.jpsychires.2024.11.037","url":null,"abstract":"<div><div>Executive dysfunction and dysregulated inflammation are found in patients with different psychiatric disorders. However, whether there are different associations between inflammatory markers and executive performance in patients with different psychiatric diagnoses is unknown. Our study aims were (1) to compare peripheral cytokine expression and executive function in patients with bipolar disorder (BD), substance use disorder (SUD), and schizophrenia (SCZ), and in healthy controls (HC) and (2) to explore the potential association between inflammatory cytokines and executive function in different patient groups and HC. Participants with BD (n = 816), SUD (opioid use disorder and/or methamphetamine use disorder, n = 518), SCZ (n = 146), and HC (n = 186) were recruited. Plasma cytokine levels [tumor necrosis factor (TNF)-α, interleukin (IL)-8 (only measured in 8 SCZ patients), transforming growth factor (TGF)-β1 (not measured in SCZ patients)], C-reactive protein (CRP), brain-derived neurotrophic factor (BDNF) levels, and executive function [Wisconsin Card Sorting Test (WCST) and Continuous Performance Test (CPT)] were assessed. We found that all patient groups had worse executive performance and higher inflammatory cytokine levels than the HC group. SCZ patients had the worst executive performance, while SUD patients had the highest inflammatory cytokine levels. Increased plasma IL-8, CRP, and TNF-α levels were specifically associated with worse executive function in BD, SUD, and SCZ patients (P = 0.009, <strong>0.04</strong>, and 0.03, respectively). We concluded that dysregulated inflammation might be a transdiagnostic feature among different psychiatric disorders and associated with executive dysfunction. Further studies to investigate the causal relationship and mechanisms between inflammation and executive dysfunction may be needed.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 160-168"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of daily temperature variations on years of life lost from suicide in the capital city of South Korea","authors":"Subin Jeong ,&nbsp;Gyeongchan Kim ,&nbsp;Sunwoo Kang ,&nbsp;Jiyun Jung ,&nbsp;Woojae Myung ,&nbsp;Hyewon Lee","doi":"10.1016/j.jpsychires.2024.11.042","DOIUrl":"10.1016/j.jpsychires.2024.11.042","url":null,"abstract":"<div><div>Suicide is one of the important public health issues among mental health problems. Given that suicide significantly increases the risk of premature death, it is essential to identify potential risk factors for its prevention. It has been known that meteorological variables have an impact on suicide, but the influence of temperature variations on suicide has been undetermined. A generalized additive model utilizing a Gaussian distribution was used to assess the association between diurnal temperature range (DTR) and YLLs from suicide after rigorous adjustment for confounders, including temperature. Moreover, the lag effects of DTR up to 7 days were considered when performing the main analysis and subgroup analyses by sex, age, level of education, occupation, marital status, place of death, suicide method, and season. DTR and YLLs from suicide showed a significant positive association over various lag structures. The best-fitting lag structure was lag 0–6 (7.03 years, 95% confidence intervals: 3.49, 10.58 years). In subgroup analyses, DTR and YLLs from suicide showed the most significant associations in males (3.79 years), those in the age group of 36–64 years (4.22 years), unemployed (5.02 years), unmarried (3.98 years), death inside buildings (5.42 years), violent method (6.66 years), and spring (4.30 years). Our study offers new evidence that DTR may contribute as a risk factor for YLLs from suicide. Our finding can be considered when establishing preventive measures for premature death from suicide.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 108-115"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fasting the brain for mental health","authors":"Roberto Carlos Perez-Kast,&nbsp;Alberto Camacho-Morales","doi":"10.1016/j.jpsychires.2024.11.041","DOIUrl":"10.1016/j.jpsychires.2024.11.041","url":null,"abstract":"<div><div>Unfavorable socioeconomic and geopolitical conditions such as poverty, violence and inequality increase vulnerability to mental disorders. Also, exposure to a poor nutrition such as high-energy dense (HED) diets has been linked to alterations in brain function, leading to anxiety, addiction, and depression. HED diets rich in saturated fatty acids or obesity can activate the innate immune system in the brain, especially microglia, increasing proinflammatory cytokines such as interleukin 1 beta (IL1-β) and interleukin 6 (IL-6), in part, by the stimulation of toll-like receptor 4 (TLR4) and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Intermittent fasting (IF), an eating protocol characterized by alternating periods of fasting with periods of eating, has gained recognition as a weight-management strategy to reduce obesity. Accordingly, during IF inflammation and brain function can be modulated by production of ketone bodies and modulation of the intestinal microbiota, which also promote the induction of brain-derived neurotrophic factor (BDNF), which is involved in neurogenesis and neuronal plasticity. Although IF has contributed to reduce body weight and improve metabolic profiles, its influence on mental health remains an evolving field of research. Here, we provide experimental evidence supporting the role of IF reducing neuroinflammation as a valuable approach to improve mental health.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 215-224"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of suicide reattempt according to the type of brief contact interventions in the VigilanS program: The critical role of PTSD and anxiety disorders","authors":"Alice Demesmaeker ,&nbsp;Ali Amad ,&nbsp;Wivine Blekic ,&nbsp;Charles-Edouard Notredame ,&nbsp;Thomas Selosse ,&nbsp;Vincent Jardon ,&nbsp;Guillaume Vaiva ,&nbsp;Fabien D’Hondt","doi":"10.1016/j.jpsychires.2024.11.031","DOIUrl":"10.1016/j.jpsychires.2024.11.031","url":null,"abstract":"<div><h3>Introduction</h3><div>Global suicide rates highlight the critical need for effective preventive measures. Brief contact interventions (BCIs), such as France's Vigilans program, provide cost-effective prevention strategies. This study evaluates the suicide reattempt risk following BCIs in the aftermath of suicide attempt (SA) and identifies sociodemographic and clinical predictors to guide targeted prevention efforts.</div></div><div><h3>Method</h3><div>We conducted a prospective cohort analysis of 1044 non-first-time suicide attempters, enrolled in the Vigilans program between 2015 and 2020. The program offers diverse BCIs: a phone call only; a phone call followed by postcards (if in suicidal crisis); postcards only (if unreachable); and no intervention (if unreachable and have not provided an address). We used a multivariate Cox model and a multinomial logistic regression to examine the risk associated with each intervention and identify factors influencing intervention receipt.</div></div><div><h3>Results</h3><div>Compared to sole phone call, participants who received both a phone call and postcards, only postcards, or no intervention had a higher risk of suicide reattempt. Posttraumatic stress disorder (PTSD) was linked to a higher likelihood of receiving both a phone call and postcards, postcards only, or no intervention. Panic disorder was associated with receiving both a phone call and postcards, while generalized anxiety disorder (GAD) was linked to receiving postcards only.</div></div><div><h3>Conclusion</h3><div>Participants who received interventions beyond a singular phone call faced higher risks of subsequent SAs. Because these groups had greater suicidality or did not adhere to the program, this finding underscores the importance of tailoring interventions to the specific needs of patients with varying levels of suicidality.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 29-35"},"PeriodicalIF":3.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing genetic discovery through narrow phenotyping in schizophrenia","authors":"Anna Yakovchik ,&nbsp;Aleksandra Mamchur ,&nbsp;Daria Kashtanova ,&nbsp;Mikhail Ivanov ,&nbsp;Elena Zelenova ,&nbsp;Maria Bruttan ,&nbsp;Lorena Matkava ,&nbsp;Mikhail Terekhov ,&nbsp;Aleksandra Nekrasova ,&nbsp;Aleksander Nekrasov ,&nbsp;Sergey Mitrofanov ,&nbsp;Vasilisa Astafieva ,&nbsp;Andrey Shingaliev ,&nbsp;Konstantin Pavlov ,&nbsp;Olga Pavlova ,&nbsp;Kira Nebogina ,&nbsp;Anna Morozova ,&nbsp;Aleksander Kozlov ,&nbsp;Vladimir Yudin ,&nbsp;Valentin Makarov ,&nbsp;Veronika Skvortsova","doi":"10.1016/j.jpsychires.2024.11.033","DOIUrl":"10.1016/j.jpsychires.2024.11.033","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia varies greatly from person to person, mainly because of its polygenic nature. Consequently, schizophrenia patients form distinct subphenotypes of schizophrenia, with specific symptom patterns and outcomes.</div></div><div><h3>Methods</h3><div>This study included 4257 adults, with long-term schizophrenia (control - 8955 individuals) who were assessed for schizophrenia with potentially severe outcomes based on following criteria: disability in functional and/or physical domains before the age of 40; severe negative symptoms (present in infancy or shortly after onset); a continuous course of the disease. Additionally, the time of the onset and aggressive/antisocial tendencies were assessed as one the predictors of potentially severe outcomes. A total of 817 participants met at least three of these criteria, i.e., had disruptive schizophrenia. A genome-wide and transcriptome-wide association study was conducted using linear regression and the PrediXcan algorithm. The obtained data were used to develop a polygenic risk model for early risk prediction of schizophrenia with potentially severe outcomes.</div></div><div><h3>Results</h3><div>Significant associations were found between schizophrenia and variants in <em>CAMTA1</em>, <em>TRHDE</em>, <em>NELFE</em>, and others. The PRS model demonstrated high performance in training, internal and external validation (ROC AUC of 0.9, 0.89, and 0.68, respectively). The functional pathway analysis highlighted pathways involved in ATP metabolism, myeloid cell differentiation, and apoptotic processes.</div></div><div><h3>Conclusion</h3><div>Subphenotyping schizophrenia may enhance the discovery of genetic factors affecting its development and progression. The GWAS and TWAS findings revealed general mechanisms involved in the development of schizophrenia with potentially severe outcomes, such as synapse regulation, inflammation, and apoptosis.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 55-63"},"PeriodicalIF":3.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the response to antipsychotics or mood stabilizers in patients with acute mania: An individual patient data meta-analysis of placebo-controlled studies.","authors":"Bram W C Storosum, Sem E Cohen, Taina K Mattila, Kit C B Roes, Carlijn Welten, Wim van den Brink, Lieuwe de Haan, Damiaan Denys, Jasper B Zantvoord","doi":"10.1016/j.jpsychires.2024.11.014","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.014","url":null,"abstract":"<p><p>Evidence suggests a worse clinical course in women compared to men with bipolar disorder. However, little research has explored gender differences in the efficacy of anti-manic medication. We sought to determine whether there are gender differences in efficacy of drug treatment in acute manic episodes of bipolar I disorder, and the influence of dichotomized age as a proxy for menopausal status and baseline severity on gender differences. We performed an individual patient data meta-analysis of 10 short term placebo controlled registration trials for treatment of acute mania (N = 2199) performed between 1996 and 2007 using the (Young) Mania Rating Scale ((Y)MRS)) as outcome. We observed a difference in effect size in mean change and responder status between men and women (NNT = 6.3 vs. 5.3), with a small but significant effect of gender on treatment response (β = 0.031). The effect size was larger in women older than 47 compared to women aged 47 and under (NNT = 4.2 vs. 7.5), and to a lesser extent, larger in men over 47 years compared those aged 47 and under (NNT = 3.8 vs. 6). Results were mainly driven by differences in response in the placebo group and independent of baseline severity. These findings suggest that men and premenopausal women might have a clinically modest advantage over their women and postmenopausal counterparts in treatment with anti-manic medication. Our results were limited by our sample not including antimanic agents registered after 2007 and by the absence of direct biological information regarding sex and menopausal state. Future research should aim to replicate current findings utilizing biological confirmation on the menopausal status and test whether findings are generalizable to newer antimanic agents.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"358-364"},"PeriodicalIF":3.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming the lack of alternatives - Changes in the use of coercive measures after implementation of the recovery-oriented \"Weddinger Modell\" in acute psychiatric care.","authors":"Anastasia Korezelidou, Annika Welte, Anna Oster, Lieselotte Mahler","doi":"10.1016/j.jpsychires.2024.11.032","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2024.11.032","url":null,"abstract":"<p><strong>Introduction: </strong>Due to the ethical conflict potential and far-reaching negative consequences of coercive measures (CM) in acute psychiatry, approaches to reduce the use of CM are investigated increasingly. One approach is the recovery-, resilience-, and patient-centered \"Weddinger Modell\" (WM) for inpatient psychiatric care. The present study evaluates the WM and investigates whether cases affected by CM, cases affected by seclusion or restraint, and the number, total duration, and average individual duration of CM per case are significantly reduced after WM-implementation.</p><p><strong>Methodology: </strong>This is a retrospective study based on data from patient records. The main implementation phase of the WM (WM-MIP) was defined as the period between May and August 2020. Cases treated between July 2019 and June 2021 were included. To compare changes in the use of CM before and after the WM-MIP, different multilevel regression models were applied (with n = 1656 cases and n = 194 cases affected by CM, respectively).</p><p><strong>Results: </strong>Cases affected by seclusion and the number of CM per case were significantly reduced after WM-MIP. No significant difference was found in terms of CM affected (total) or restraint affected, total CM duration, and average single CM duration per case.</p><p><strong>Discussion: </strong>The results indicate a positive effect of the WM with regard to the reduction of CM. In terms of further spread of the WM, the implementation process should be studied in detail, especially to identify key components to reduce CM.</p><p><strong>Conclusion: </strong>The WM should be considered as an approach to reduce CM.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"405-410"},"PeriodicalIF":3.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of InterRhythmic care for depression: A randomized control trial","authors":"Chuchen Xu ,&nbsp;Yanhong Geng ,&nbsp;Xiaohe Fan ,&nbsp;Zheyi Wei ,&nbsp;Weichieh Yang ,&nbsp;Fan Wang ,&nbsp;Yiming Chen ,&nbsp;Bin Xie ,&nbsp;Wu Hong","doi":"10.1016/j.jpsychires.2024.11.028","DOIUrl":"10.1016/j.jpsychires.2024.11.028","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the efficacy of an InterRhythmic Care (IRC) for major depressive disorder (MDD). There is a lack of clinical studies on its effect on depression.</div></div><div><h3>Methods</h3><div>In this eight-week, randomized, single-blind, controlled trial, 120 patients with MDD were randomly assigned to receive IRC or Internet general psychoeducation (IGP). Participants’ depressive and anxiety symptoms, interpersonal relationships, social function, and biological rhythms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), Interpersonal Comprehensive Diagnostic Scale (ICDS), Sheehan Disability Scale (SDS), and Morning and Evening Questionnaire (MEQ) at baseline and the 8th week.</div></div><div><h3>Results</h3><div>Compared to participants in IGP, participants in IRC had lower HAMD total scores, anxiety/somatization, weight, cognitive disturbance, retardation, and sleep disturbance subscores in patients with MDD (F = 190.94, p _Bonferroni &lt; 0.001; F = 83.13, p _Bonferroni &lt; 0.001; F = 4.15, p _Bonferroni = 0.048; F = 65.42, p _Bonferroni &lt; 0.001; F = 53.15, p _Bonferroni &lt; 0.001; F = 67.76, p _Bonferroni &lt; 0.001, respectively); HAMA total score, somatic anxiety subscore, psychogenic anxiety subscore (F = 142.97, p _Bonferroni &lt; 0.001; F = 111.06, p _Bonferroni &lt; 0.001; F = 128.04, p _Bonferroni &lt; 0.001); ICDS total score and subscores for conversation, making friends, manners; and SDS subscores for work/school, social life, family life, and days underproductive (F = 17.38, p _Bonferroni &lt;0.001; F = 14.61, p _Bonferroni &lt; 0.001; F = 10.97, p _Bonferroni = 0.001; F = 11.74, p _Bonferroni = 0.001; F = 4.85, p _Bonferroni = 0.031; F = 16.29, p _Bonferroni &lt; 0.001; F = 12.11, p _Bonferroni = 0.001; F = 8.3, p _Bonferroni = 0.005) at the end of the intervention period.</div></div><div><h3>Conclusions</h3><div>IRC helped patients with MDD improve clinical symptoms, including depressive and anxiety symptoms, interpersonal problems, and social function.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 36-45"},"PeriodicalIF":3.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}