Journal of psychiatric research最新文献

{"title":"Relationship between serum oxidative stress and blood brain barrier parameters in patients with major depression","authors":"Hatice Solak ,&nbsp;Merve Akkuş ,&nbsp;Pınar Aydogan Avşar","doi":"10.1016/j.jpsychires.2025.07.023","DOIUrl":"10.1016/j.jpsychires.2025.07.023","url":null,"abstract":"<div><h3>Objective</h3><div>Research emphasises the critical role of blood-brain barrier (BBB) integrity in psychiatric disorders. This study aimed to investigate the relationship between serum Zonula occludens protein - 1 (ZO-1) and serum occludin levels, which are blood brain barrier markers, and serum oxLDL levels, which are known to be associated with oxidative stress and inflammation, in patients with major depression.</div></div><div><h3>Methods</h3><div>The study included 44 drug-naïve patients diagnosed with Major Depressive Disorder (MDD) and 48 healthy controls matched for Body Mass Index (BMI), gender, age. Laboratory data, together with concentrations of Ox-LDL, Occludin, ZO-1, were evaluated. The Hamilton Depression Rating Scale (HADRS) was employed to evaluate the severity of depression in the major depression cohort.</div></div><div><h3>Result</h3><div>Compared to healthy controls, patients with major depression exhibited significantly lower serum levels of ZO-1 (p = 0.001) and occludin (p = 0.001), while oxLDL levels were significantly higher (p = 0.001). The differences maintained as significant after corrections for age, sex, smoking, and BMI via ANCOVA (all p = 0.001). A positive correlation was identified between ZO-1 and occludin levels (r = .400, p = 0.001), whereas a negative correlation was found between ZO-1 and oxLDL levels (r = −.369, p = 0.001).</div></div><div><h3>Conclusion</h3><div>This study's findings indicate that serum oxLDL levels, related with oxidative stress and inflammation in the pathogenesis of MDD, may influence the alteration of serum ZO-1 and occludin levels, recognised as indicators of the BBB.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 25-31"},"PeriodicalIF":3.2,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial deformation and pro-arrhythmic indices in first-episode patients with psychosis before and one year after the initiation of antipsychotic treatment","authors":"Marios Plakoutsis ,&nbsp;Aris Bechlioulis ,&nbsp;Aidonis Rammos ,&nbsp;Spyridon Sioros ,&nbsp;Andreas Karampas ,&nbsp;Georgios Georgiou ,&nbsp;Lampros K. Michalis ,&nbsp;Katerina K. Naka ,&nbsp;Petros Petrikis","doi":"10.1016/j.jpsychires.2025.07.022","DOIUrl":"10.1016/j.jpsychires.2025.07.022","url":null,"abstract":"<div><h3>Aim</h3><div>To assess the risκ of subclinical myocardial dysfunction and pro-arrhythmic risk in a cohort of antipsychotic naive patients with a First Episode of Psychosis (FEPs) and to evaluate the effects of antipsychotic treatment at one year follow-up.</div></div><div><h3>Methods</h3><div>Eighty eight consecutive patients diagnosed with a First Episode of Psychosis (FEPs) were assessed by 24-h Holter electrocardiogam monitoring (including QT analysis and heart rate variability indices) and a thorough echocardiographic study (including myocardial strain analysis – global longitudinal strain GLS). A sub-group of 33 patients was re-evaluated one year after the initiation of antipsychotic treatment.</div></div><div><h3>Results</h3><div>A 24-hr QTc maximum value &gt; 500 msec was found in 35 % but no patient had a 24-hr QTc mean value &gt; 500 msec. Abnormal values of SDNNI &lt;50 msec, HRV index &lt;60 and low RMSSD &lt;20 msec were observed in 44 %, 96 % and 30 % of the population. All patients had a LVEF value &gt; 50 % (58.9 ± 5.7 %). The GLS measurement was found −18.3 ± 2.4 i.e. 14 % of the patients had a low GLS &gt; -16 %. QTc maximum values in 24-hr holter was increased following treatment (p = 0.014). There was a trend for an increase in PNN50 following treatment (p = 0.076). GLS was significantly improved at follow-up (−17.5 ± 2.41 vs −18.6 ± 2.51, p = 0.007).</div></div><div><h3>Conclusions</h3><div>Abnormal autonomous system function and subclinical myocardial dysfunction of the left ventricle were found in a significant proportion of antipsychotic-naïve, FEP patients. After one year of treatment, improvement was observed in left ventricular function with a concomitant increase in maximum QTc interval.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 76-83"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shorter telomere length in obsessive-compulsive disorder: another evidence of neuroprogression?","authors":"Fabiana Barzotto Kohlrausch ,&nbsp;Glenda da Silva Rodrigues de Oliveira ,&nbsp;Cícero Brasileiro de Mello Neto ,&nbsp;Leonardo F. Fontenelle","doi":"10.1016/j.jpsychires.2025.07.024","DOIUrl":"10.1016/j.jpsychires.2025.07.024","url":null,"abstract":"<div><h3>Background and objectives</h3><div>There is evidence suggesting that obsessive-compulsive disorder (OCD) is a neuroprogressive illness. Telomeres, protective caps at the ends of chromosomes that prevent DNA damage, have been regarded as a potential biological marker associated with disease susceptibility and aging. In this study, we aimed to evaluate telomere length (TL) in OCD patients from Southeast Brazil. <strong>Methods</strong>: A total of 210 Brazilian individuals were included, 105 OCD patients and 105 control individuals. All participants were matched by age and sex between the two groups. DNA was extracted from buccal cells, and TL (T/S ratio) was assayed by multiplex quantitative polymerase chain reaction method (mmqPCR). <strong>Results</strong>: OCD patients exhibited significantly shorter TL than controls (p &lt; 0.0001) in both sexes (males, p = 0.034 and females, p = 0.002). Also, TL correlated negatively with duration of illness, both in the total patients’ sample (rho = −0.297, p = 0.003) and in the female OCD sample (rho = −0.341, p = 0.009). Age did not correlate with TL in controls, but it did correlate with TL in OCD subjects (p &lt; 0.0001). Further, partial correlation analysis between TL and duration of illness, controlling for age, rendered the association non-significant. Age of onset and OCD symptom dimensions were not associated with TL in OCD patients. <strong>Conclusions</strong>: OCD patients have shorter telomeres than controls, independently of sex. OCD female patients with longer illness duration have also shorter telomeres. Further studies are needed to clarify the mechanisms underlying this relationship and confirm telomere shortening as a promising biomarker of neuroprogression of OCD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 513-520"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences and adult trait anxiety: The mediating role of metacognition","authors":"Zita Fekete,&nbsp;Dorottya Kovács-Horváth,&nbsp;Barnabás Oláh,&nbsp;Beáta Kovács-Tóth","doi":"10.1016/j.jpsychires.2025.07.027","DOIUrl":"10.1016/j.jpsychires.2025.07.027","url":null,"abstract":"<div><h3>Background</h3><div>Adversities suffered at an early age lead to negative long-term effects impacting the development of the emotional, social, and cognitive domains of the personality, including metacognitive skills.</div></div><div><h3>Objective</h3><div>We aimed to investigate the mediating role of metacognition in the impact exercised by early adversities on trait anxiety.</div></div><div><h3>Participants</h3><div>Participants (all over 18) were recruited from the general population (n = 304).</div></div><div><h3>Methods</h3><div>Adverse childhood experiences were assessed using the 10-item Adverse Childhood Questionnaire, for the assessment of maladaptive metacognitive beliefs the Meta-Cognitions Questionnaire was applied, while the level of the trait anxiety was investigated using the Trait Version of the State-Trait Anxiety inventory. To examine the mediating effect of metacognition between early adversities and trait anxiety mediation analysis was used.</div></div><div><h3>Results</h3><div>Adverse childhood experiences have a moderate effect on trait anxiety (β = 0.348, p &lt; 0.001). More than half of the revealed associations were shown to be due to the maladaptive functioning of metacognition (Pm = 56.03 %). As regards specific maladaptive metacognitive beliefs, it was found that negative metacognitive beliefs (Pm = 61.49 %), the need to control thoughts (Pm = 46.0 %), and the lack of cognitive confidence (Pm = 30.07 %) play a crucial role in the mediating effect of metacognition.</div></div><div><h3>Conclusions</h3><div>We can assume that the overall negative impact of early adversities on development is also manifested by the inadequacy of metacognition, which contributes to anxiety proneness. This inadequacy leads to the development of maladaptive metacognitive beliefs that prevent proper monitoring and correcting of the individual's internal contents, further increasing the level of trait-like anxiety.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 536-543"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathological profiles of adolescent presenting to emergency departments following a suicide attempt: A comprehensive analysis.","authors":"Ainoa García-Fernández, Clara Martínez-Cao, Iván Pérez-Díez, Jorge Andreo-Jover, Wala Ayad-Ahmed, Teresa Bobes-Bascarán, Manuel Canal Rivero, Ana Isabel Cebriá, Benedicto Crespo-Facorro, Marina Díaz-Marsa, Ana González-Pinto, Sandra A Gómez, Iria Grande, Luis Jiménez-Treviño, Purificación López, Pablo Mola-Cardenes, Arancha Ortiz Villalobos, Diego J Palao, Ángela Palao-Tarrero, Miguel Ruiz Veguilla, Natalia Roberto, Yolanda Sánchez-Carro, Alejandro de la Torre-Luque, Víctor Pérez, Iñaki Zorrilla, Pilar A Sáiz","doi":"10.1016/j.jpsychires.2025.07.035","DOIUrl":"https://doi.org/10.1016/j.jpsychires.2025.07.035","url":null,"abstract":"<p><strong>Background: </strong>Despite the identification of several risk factors, an understanding of the role of specific psychopathological profiles in association with adolescent suicidal behaviours remains a key challenge in public health research. The study aimed to identify psychopathological profiles in suicidal adolescents and to analyse their association with suicide-related outcomes.</p><p><strong>Methods: </strong>A total of 285 adolescents aged 12-17 years [mean age (SD) = 14.98 (1.51); females: 249 (87.40 %)] who had attempted suicide within the past 10 days were recruited from different Spanish hospitals. Clinical assessments included psychiatric diagnoses, depressive symptoms, trauma, impulsivity, and suicidal thoughts and behaviours. Latent profile analysis was performed to classify subgroups with similar patterns based on self-report Strengths and Difficulties Questionnaire. Logistic regression and generalised linear modelling were applied to examine the relationship between profile membership and suicidal behaviours.</p><p><strong>Results: </strong>Three psychopathological profiles were identified: internalizing symptom profile (52.63 %), externalizing symptom profile (24.21 %), and low symptom profile (25.58 %). The predominantly female internalizing symptom profile members were more likely to report higher levels of psychopathological symptoms, including number of psychiatric diagnoses, depressive symptoms, and trauma (except sexual abuse). Additionally, they had more non-suicidal self-injury and suicidal thoughts and behaviours. Likewise, greater ideation intensity was associated with the internalizing symptom profile compared to other groups, while greater number of previous suicide attempts correlated with an increase in suicidal behaviours. Finally, higher levels of motor impulsivity were associated with a lower probability of suicidal behaviours.</p><p><strong>Conclusions: </strong>Identifying symptom profiles among adolescents who have attempted suicide provides a valuable framework for guiding suicide prevention and personalized interventions. These findings support the use of tailored approaches, such as DBT-A or CBT for internalizing symptoms, and behavioural or family-based interventions for externalizing traits.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"169-180"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the timing of trauma, PTSD onset, and DNA methylation: A multicohort investigation of candidate CpG sites","authors":"Kyle J. Bourassa ,&nbsp;Melanie E. Garrett ,&nbsp;Lauren Hair ,&nbsp;Michelle Dennis ,&nbsp;Karen Sugden ,&nbsp;Benjamin Williams ,&nbsp;Madeline H. Meier ,&nbsp;Renate Houts ,&nbsp;VA Mid Atlantic MIRECC Workgroup ,&nbsp;Jean C. Beckham ,&nbsp;Allison E. Ashley-Koch ,&nbsp;Reremoana F. Theodore ,&nbsp;Richie G. Poulton ,&nbsp;Terrie E. Moffitt ,&nbsp;Avshalom Caspi ,&nbsp;Nathan A. Kimbrel","doi":"10.1016/j.jpsychires.2025.07.026","DOIUrl":"10.1016/j.jpsychires.2025.07.026","url":null,"abstract":"<div><div>Epigenome-wide association studies (EWAS) have identified cytosine-phosphate-guanine sites (CpGs) associated with trauma and PTSD. However, prior studies have largely focused on cross-sectional associations, and it remains unclear whether epigenetic profiles associated with traumatic stress might predispose individuals to develop PTSD or might change in response to PTSD. In this study, we characterized associations between traumatic stress and three CpGs identified in previous EWAS of PTSD (cg05575921 and cg26703534 in <em>AHRR</em>, and cg19534438 in <em>G0S2</em>) using two cohorts—the Dunedin Multidisciplinary Health and Development Study (<em>n</em> = 846) and the Post-Deployment Mental Health Study (PDMH; <em>n</em> = 2309). We first replicated cross-sectional associations, and then investigated the time course linking PTSD, trauma, and DNA methylation. In cross-sectional analyses, we found trauma and PTSD were consistently associated with hypomethylation at cg05575921—including at age 26, 38, and 45 in the Dunedin Study—whereas neither cg26703534 nor cg19534438 showed consistent associations. These results were robust to multiple methods of accounting for tobacco exposure, which is notable given associations between smoking and changes in <em>AHRR</em>. In the Dunedin Study, we also found that people who developed PTSD between age 26 and 45 showed greater hypomethylation at cg05575921 over the same period, however, people with hypomethylation at cg05575921 at age 26 were no more likely to develop future PTSD. Hypomethylation at cg05575921 was also associated with childhood adversity in the Dunedin Study and a past diagnosis of PTSD in the PDMH. Our findings suggest traumatic stress is associated with cg05575921 in the <em>AHRR</em> gene, and that trauma and PTSD may be associated with changes in cg05575921.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"189 ","pages":"Pages 528-535"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupressure as a non-pharmacological treatment for depression: Neurophysiological, biochemical, and psychological mechanisms","authors":"Cong-Ya Chen,&nbsp;Yi Zhang","doi":"10.1016/j.jpsychires.2025.07.036","DOIUrl":"10.1016/j.jpsychires.2025.07.036","url":null,"abstract":"<div><div>Depression is a common and serious psychological disorder with high prevalence and recurrence rates. Still, there are treatment-resistant depression in the clinic, so exploring other treatments is necessary. Acupressure is a non-invasive therapeutic method based on the principles of traditional Chinese medicine, which promotes health and relieves symptoms by applying pressure to specific acupoints on the body. Modern medical research on acupressure has gradually deepened, explaining and validating it through multiple perspectives, e.g., physiology, neurology, and biochemistry. However, the mechanisms underlying the treatment of depression with acupressure, the adoption of a multidisciplinary model of collaboration in treatment, and the improvement of the quality of related research have not yet been thoroughly described. Therefore, the present review summarized the mechanisms, including the neurophysiological, biochemical, and psychological mechanisms behind the treatment of depression with acupressure, its strengths (e.g., no side effects, easy operation, and good patient compliance), and limitations (e.g., individual differences in effects and lack of large-scale systematic studies) in treatment of depression and researches, and its potential for collaboration with other therapies (e.g., acupressure with medication, psychotherapy, and other Chinese medicine), and multidisciplinary approaches.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 32-46"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A population-based study assessing posttraumatic stress disorder and acute stress disorder in Turkish adults","authors":"Gizem Karaoğlan ,&nbsp;Fatih Ekici ,&nbsp;Lütfi Saltuk Demir ,&nbsp;Özkan Güler","doi":"10.1016/j.jpsychires.2025.07.034","DOIUrl":"10.1016/j.jpsychires.2025.07.034","url":null,"abstract":"<div><h3>Purpose</h3><div>This study investigated the prevalence and associated factors of traumatic experiences, post-traumatic stress disorder (PTSD) and acute stress disorder (ASD) in a sample of Turkish adults.</div></div><div><h3>Methods</h3><div>The study was conducted in 30 family health centres in Konya Province, Turkey, which were selected by simple random sampling. The sample comprised 1587 people aged ≥18 years recruited by systematic sampling from neighbourhoods served by the centres. Socio-demographic data were collected, followed by face-to-face diagnostic interviews using the Structured Clinical Interview for DSM-5 (SCID-5) for PTSD. After the traumatic event exposure was examined according to SCID-5 traumatic event criteria, a separate clinical interview was conducted with DSM-5 diagnostic criteria to investigate ASD prevalence.</div></div><div><h3>Results</h3><div>The lifetime prevalence of experiencing at least one traumatic event was 54.9 % in the whole sample. The lifetime PTSD prevalence was 2.6 % (conditional prevalence: 4.7 %). PTSD was correlated with female gender, young age, being separated/divorced/widowed, retirement status, comorbid psychiatric illness, and suicide attempt. The conditional risk of PTSD was highest in sexual violence events (rape, 18.7 %; other sexual assaults, 20.5 %), followed by torture (16.7 %) and sudden violent death (10.8 %). Interpersonal violence (36.6 %) and sexual violence (26.9 %) were the most common traumatic event groups among individuals who developed PTSD. The lifetime ASD prevalence was 4.4 % (conditional prevalence: 8 %). Among socio-demographic variables, ASD was associated only with female gender.</div></div><div><h3>Conclusion</h3><div>The prevalence of traumatic experiences in Turkish adults indicates the need for support programmes aimed at rapid awareness and treatment to reduce chronicity, suicide and loss of function.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 17-24"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How parental mental health is connected to internet gaming disorder in adolescents: The role of family functioning","authors":"Nanami Hiratani ,&nbsp;Ayumi Takano ,&nbsp;Koki Ono ,&nbsp;Kyosuke Kaneko ,&nbsp;Toshitaka Hamamura ,&nbsp;Masaya Ito ,&nbsp;Maki Taniguchi","doi":"10.1016/j.jpsychires.2025.07.029","DOIUrl":"10.1016/j.jpsychires.2025.07.029","url":null,"abstract":"<div><div>Parents of adolescents with internet gaming disorder (IGD) are at a high risk of psychological distress. Good family functioning may play a protective role in the mental health of parents of adolescents with IGD. Hence, this study examined the moderating effect of family functioning on the association between adolescent IGD and parental mental health. Apropos this, online self-report questionnaires were administered to Japanese adolescents and their parents in June 2023. In total, 643 dyads were included in the analysis. Among adolescents, 399 (62.1 %) were boys, and the average age was 14.2 years. Among parents, 312 (48.5 %) were fathers, and the average age was 47.0 years. The survey included demographic characteristics and measures of adolescent IGD, family functioning, and parental mental health using validated scales. Responses to the Family Adaptability, Partnership, Growth, Affection, and Resolve Index (Family APGAR) and the Kessler Psychological Distress Scale (K6) were collected only from the parents. We used logistic regression analysis to examine the main effects of adolescent IGD and family functioning on parental mental health and the interaction between adolescent IGD and family functioning. The main effect on parental psychological distress was of adolescent IGD. Better family functioning was significantly and negatively associated with parental psychological distress. Thus, more severe IGD in adolescents was associated with greater levels of parental psychological distress, and family functioning did not moderate this association. Our findings suggest that family functioning may be limited in preventing parental psychological distress due to adolescent IGD and that parental mental health needs to be assessed and cared for in adolescent IGD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 11-16"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised pilot study comparing brief psychodynamic therapy with cognitive-behavioural therapy in the treatment of patients with fibromyalgia","authors":"Annunziata Romeo ,&nbsp;Marialaura Di Tella ,&nbsp;Virginia Perutelli ,&nbsp;Federica Galli ,&nbsp;Giuliano Carlo Geminiani ,&nbsp;Lorys Castelli","doi":"10.1016/j.jpsychires.2025.07.037","DOIUrl":"10.1016/j.jpsychires.2025.07.037","url":null,"abstract":"<div><h3>Background</h3><div>The present study mainly aimed to assess the effectiveness of Brief Psychodynamic Therapy (BPT) with respect to Cognitive-Behavioural Therapy (CBT) for the treatment of patients with Fibromyalgia (FM). As a secondary goal, we evaluated whether individual characteristics (attachment dimensions and alexithymia) contributed to predict treatment outcomes (anxiety and depression symptoms, and pain intensity).</div></div><div><h3>Methods</h3><div>A pilot randomised trial was conducted, with two repeated measures (at baseline - T0, and after the intervention - T1). Sixty-one female patients with FM were randomly allocated to the BPT group or CBT group and filled out the following questionnaires pre- and post-treatment: the Hospital Anxiety and Depression Scale (HADS), Fibromyalgia Impact Questionnaire (FIQ-R) Pain, Toronto Alexithymia Scale (TAS-20), and Relationship Questionnaire (RQ).</div></div><div><h3>Results</h3><div>Results of mixed-design ANOVAs revealed that there was an effect of time on both anxiety and pain symptoms scores, with a decrease in these symptoms from T0 to T1. Conversely, no group effect or time by group interaction was found. Multiple regression analyses showed that both the RQ “Dismissing” and TAS-20 total score were significant predictors of pain intensity after treatment. The TAS-20 total score was found to be the only predictor of HADS-Anxiety and HADS-Depression scores post-treatment.</div></div><div><h3>Conclusions</h3><div>The present findings have shown that both psychotherapies seem to be equally effective in reducing anxiety symptoms and pain intensity in FM. Furthermore, both attachment and alexithymia were found to be significant predictors of pain intensity, whereas only alexithymia predicted anxiety and depression symptoms in the aftermath of treatment.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"190 ","pages":"Pages 145-153"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}