Journal of psychiatric research最新文献

{"title":"Challenges in maintaining remission after ECT – Insights from a six-month follow up study","authors":"Linda van Diermen ,&nbsp;Simon Lambrichts ,&nbsp;Jesse Berwouts ,&nbsp;Kaat Hebbrecht ,&nbsp;Seline van den Ameele ,&nbsp;Violette Coppens ,&nbsp;Jean-Baptiste Belge ,&nbsp;Didier Schrijvers ,&nbsp;Tom Birkenhäger","doi":"10.1016/j.jpsychires.2025.01.009","DOIUrl":"10.1016/j.jpsychires.2025.01.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Electroconvulsive therapy (ECT) is a widely recognized treatment for severe depressive disorders, particularly in cases of inadequate response to pharmacological interventions or when rapid symptom relief is essential. Although ECT demonstrates high efficacy, a notable proportion of patients relapse after a successful ECT course.</div></div><div><h3>Methods</h3><div>This study investigated clinical baseline characteristics and residual depressive symptoms associated with relapse – defined as a Montgomery-Åsberg Depression Rating Scale (MADRS) score &gt;15, restart of ECT, or suicide attempt - within six months after successful ECT. Data were obtained from the PROTECT study, a single-site, prospective cohort study conducted at the University Psychiatric Center Duffel, Belgium.</div></div><div><h3>Results</h3><div>– Among the 65 patients who completed the ECT course, 40 patients (62%) achieved remission. At six months, 32 patients were reassessed, and 18 (56%) of them experienced relapse. No significant associations were identified between relapse and baseline factors, including age, social circumstances, baseline depression severity, psychomotor symptoms, cognitive functioning, treatment resistance, lithium use, or the presence of psychotic or melancholic features. Residual depressive symptoms at the end of the ECT course also did not predict relapse.</div></div><div><h3>Discussion</h3><div>– The observed high relapse rate underscores the critical need for robust continuation and maintenance strategies following ECT. Future research should prioritize larger cohorts to better identify predictors of relapse and optimize post-ECT treatment protocols.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 116-121"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG microstate analysis and machine learning classification in patients with obsessive-compulsive disorder","authors":"Mohan Ma ,&nbsp;Bingxun Lu ,&nbsp;Yumei Gong ,&nbsp;Chuman Xiao ,&nbsp;Yumeng Yang ,&nbsp;Yumeng Ju ,&nbsp;Zhenman Xi ,&nbsp;Yang Gao ,&nbsp;Xiaolin Ning ,&nbsp;Yan Zhang","doi":"10.1016/j.jpsychires.2025.01.005","DOIUrl":"10.1016/j.jpsychires.2025.01.005","url":null,"abstract":"<div><h3>Background</h3><div>Microstate characterization of electroencephalogram (EEG) is a data-driven approach to explore the functional changes and interrelationships of multiple brain networks on a millisecond scale. This study aimed to explore the pathological changes of whole-brain functional networks in patients with obsessive-compulsive disorders (OCD) through microstate analysis and further to explore its potential value as an auxiliary diagnostic index.</div></div><div><h3>Methods</h3><div>Forty-eight OCD patients (33 with more than moderate anxiety symptoms, 15 with mild anxiety symptoms) and 52 healthy controls (HCs) were recruited. Brain activities during eyes-closed period were collected using 64-channel electroencephalography. The differences in microstate features between OCD patients and HCs were compared, and the relationship between the microstate features and clinical symptoms were explored. Key microstate features were selected for machine learning modeling to achieve targeted classifications.</div></div><div><h3>Results</h3><div>The probability of transition from microstate B to C was significantly lower in OCD patients compared to HCs, and the obsessive thoughts factor scores were significantly correlated with the duration of microstate A, the occurrence of microstate B, and the transition probability from microstate C to B. The occurrence rate of microstate C was significantly negatively correlated with the Hamilton rating scale for anxiety (HAMA) scores. The AUC (Area Under the Receiver Operating Characteristic Curve) of the machine learning model in the test set classification between the above two groups and between OCD patients with more than moderate/mild anxiety symptoms could achieve 70.43% and 77.13%, respectively.</div></div><div><h3>Conclusion</h3><div>EEG microstate characteristics were altered in OCD patients, and these changes were closely associated with obsessive thoughts and anxiety symptoms. Besides, the machine learning classification model based on microstate features has limited ability to identify OCD, and further optimization on this classification approach is still needed in the future.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 186-194"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of emotional faces in clinical and subclinical depression","authors":"Nathan Ridout ,&nbsp;Barbara Dritschel ,&nbsp;Hannah Wardall ,&nbsp;Richard Day ,&nbsp;Ronan O'Carroll","doi":"10.1016/j.jpsychires.2025.01.025","DOIUrl":"10.1016/j.jpsychires.2025.01.025","url":null,"abstract":"<div><div>Impaired inhibition of emotional material is an important cognitive component of depression. The current aim was to determine if participants with major depression (MDD) and/or subclinical depression (dysphoria) exhibit impaired inhibition of sad faces on a face-word variant of the Stroop task. Study 1: patients with MDD (n = 28) and healthy controls (n = 32) were presented with positive and negative words superimposed across happy, sad, and neutral faces. Study 2: dysphoric (n = 23) and non-dysphoric (n = 35) participants were presented with positive and negative words superimposed across happy and sad faces (shown upright and inverted). Participants were told to ignore the faces and categorise the words. Patients with MDD experienced greater interference from sad faces than did the controls. Healthy controls experienced greater interference from happy than sad faces, whereas interference levels from happy and sad faces did not differ in patients with MDD. Dysphoric participants experienced greater interference from sad faces than did non-dysphoric participants, and from sad faces than happy. The amount of interference from happy and sad faces did not differ in the non-dysphoric participants. Clinical and subclinical depression are linked to impaired inhibition of sad faces, which might represent a risk factor for depression and a potential target for intervention.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 221-234"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma exposure as a risk factor of major depressive disorder: A matched case-control study","authors":"Wenjian Lai ,&nbsp;Huimin Zhang ,&nbsp;Yingchen Jiang ,&nbsp;Xinyu Huang ,&nbsp;Yuhua Liao ,&nbsp;Jiejing Hao ,&nbsp;Yifen Liu ,&nbsp;Yan Chen ,&nbsp;Wanxin Wang ,&nbsp;Lan Guo ,&nbsp;Wei-Hong Zhang ,&nbsp;Kayla M. Teopiz ,&nbsp;Roger S. McIntyre ,&nbsp;Xue Han ,&nbsp;Ciyong Lu","doi":"10.1016/j.jpsychires.2025.01.028","DOIUrl":"10.1016/j.jpsychires.2025.01.028","url":null,"abstract":"<div><div>The association between childhood trauma (CT), stressful life events (SLE) and the onset and severity of major depressive disorder (MDD) has not been extensively studied. This study aimed to investigate the separate and combined association of CT and SLE with the onset and severity of MDD. A total of 503 patients with MDD and 503 controls were included. The diagnosis of MDD was assessed using the Mini-International Neuropsychiatric Interview (M.I.N.I.) by trained psychiatrists. Trauma exposure was assessed using the short form of Childhood Trauma Questionnaire (CTQ-SF) and stressful life events screening questionnaire (SLESQ). A series of conditional logistic regression models and multiple linear regression models were performed. The majority of patients with MDD (84.9%) and controls (61.6%) have reported trauma exposure. After adjusting for covariates, exposure to CT or SLE was independently associated with an elevated risk of the onset and severity of MDD. Moreover, a significant additive interaction between CT and SLE on the onset of MDD was observed (relative excess risk due to interactions [RERI] = 6.93, 95% confidence interval [CI] = 0.19–13.66). MDD patients were more likely to experience both CT and SLE compared with controls (odds ratio [OR] = 10.37, 95% CI = 4.99–21.56). MDD patients with both CT and SLE experience were more like to have more severe depressive symptoms (β = 2.16, 95% CI = 1.02–3.30). These findings underscore the importance of targeted prevention measures addressing the occurrence of CT and SLE to mitigate the risk of MDD development and the severity of depressive symptoms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 204-211"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dorsal bed nucleus of the stria terminalis GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice","authors":"Wenjing Hu ,&nbsp;Qiyuan Wang ,&nbsp;Lifang Jiang ,&nbsp;Lina Zhang ,&nbsp;Huichao Sun ,&nbsp;Junying Bao ,&nbsp;Xiao Chen ,&nbsp;Gaole Yuan ,&nbsp;Kai Yan ,&nbsp;Yun Liu ,&nbsp;Jian Wu ,&nbsp;Tao Liu","doi":"10.1016/j.jpsychires.2025.01.034","DOIUrl":"10.1016/j.jpsychires.2025.01.034","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have shown that neurons in the Bed Nucleus of the Stria Terminalis (BNST) respond to stress and play a key role in mental health. However, the cellular bases of BNST in adolescent depression remain elusive.</div></div><div><h3>Methods</h3><div>Male C57BL/6 mice were randomly assigned to the control (Ctrl) or chronic unpredictable stress (CUS) groups. The CUS mice, aged 28 days, were subjected to diverse stressors at various times of the day for 12 days. Depression-like behaviors were assessed through the sucrose preference test (SPT) and tail suspension test (TST). Immunostaining was used to investigate the neural activity and subtypes in the brain. A chemogenetic tool was conducted to examine the role of specific neural activity in CUS-induced depression-like behaviors.</div></div><div><h3>Results</h3><div>CUS led to a significant decrease in preference for sucrose solution in the SPT and increased immobility time in the TST. C-Fos immunostaining showed hyperactivity of the GABAergic neurons within the dorsal BNST (dBNST^GABA). Chemogenetic activation of dBNST^GABA neurons increased depression-like behaviors. Conversely, chemogenetic inhibition of dBNST^GABA neurons led to a decrease in CUS-induced depression.</div></div><div><h3>Conclusions</h3><div>These results suggest that adolescent CUS induces hyperactivity of dBNST^GABA neurons, subsequently giving rise to depression-like behaviors and that reducing dBNST^GABA neuronal activity might constitute a novel and efficacious therapeutic approach for adolescent depression.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 347-357"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults","authors":"Yuxing Jared Yao ,&nbsp;Yu Chen ,&nbsp;Chiang-Shan R. Li","doi":"10.1016/j.jpsychires.2025.01.045","DOIUrl":"10.1016/j.jpsychires.2025.01.045","url":null,"abstract":"<div><h3>Introduction</h3><div>The hypothalamus plays a pivotal role in supporting motivated behaviors, including aggression. Previous work suggested differential roles of the medial (MH) and lateral hypothalamus (LH) in aggressive behaviors, but little is known about how their resting-state functional connectivity (rsFC) may relate to aggression in humans.</div></div><div><h3>Methods</h3><div>We employed the data from the Human Connectome Project (HCP) and examined the rsFC's of LH and MH in 745 young adults (393 women). We also explored sex differences in the rsFC's. We processed the imaging data with published routines and evaluated the results of voxel-wise regression on the aggression score, as obtained from Achenbach Adult Self Report, with a corrected threshold.</div></div><div><h3>Results</h3><div>The analyses revealed significant rsFC's between the LH and clusters in the middle temporal and occipital gyri across all subjects and in the thalamus for men, both in negative correlation with the aggression score. The slope test confirmed sex difference in the correlation between the LH-thalamus rsFC and aggression score. No significant rsFC was observed for the MH.</div></div><div><h3>Conclusions</h3><div>These findings suggest a role of the LH rsFC's and sex differences in the LH-thalamus rsFC in the manifestation of aggression in humans. The findings highlight the need for further research into sex-specific neural pathways in aggression and other related behavioral traits of importance to mental health.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 421-429"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health assessment of transgender youth - Should standardised psychological measures be scored by norms of birth-registered sex?","authors":"Liz A Saunders ,&nbsp;Blake S Cavve ,&nbsp;Cati S Thomas ,&nbsp;Penelope Strauss ,&nbsp;Simone Mahfouda ,&nbsp;Hans-Willem van Hall ,&nbsp;Georgia Chaplyn ,&nbsp;Julia K Moore ,&nbsp;Ashleigh Lin","doi":"10.1016/j.jpsychires.2025.01.019","DOIUrl":"10.1016/j.jpsychires.2025.01.019","url":null,"abstract":"<div><h3>Background</h3><div>Standardised psychometric measures are used in mental health care and research settings to identify risk, assist diagnosis, and assess symptom severity. Standardised scoring of these measures involves transforming respondents’ raw scores using binary sex norms. However, scoring manuals offer no guidance as to appropriate scoring methods for trans and non-binary respondents. The Child and Adolescent Health Service - Gender Diversity Service (GDS) implemented a practice to score psychometric measures twice, according to both birth-registered sex (BRS) and the other sex (OS) norms (i.e., “double-scoring”). As it was unclear which choice of norm was the most clinically useful for the identification of risk, this study investigated whether there was any clinically meaningful difference in levels of psychopathology when scoring measures by OS versus BRS norms.</div></div><div><h3>Methods</h3><div>We analysed clinical-range classification of scores (clinically significant versus sub-clinical) on four sex-normed psychometric assessment measures (Child Behavior Check List, Youth Self Report, Social Responsiveness Scale 2, and Beck Youth Inventory) completed by GENder identiTy Longitudinal Experience (GENTLE) participants, as part of standard initial assessment at the GDS (<em>N</em> = 233).</div></div><div><h3>Results</h3><div>Sub-domains within all four measures resulted in inconsistent classifications of between 0 and 15% of participants into clinical versus sub-clinical ranges when scored using OS versus BRS norm.</div></div><div><h3>Conclusion</h3><div>Scoring sex-normed standardised psychometric measures by BRS or OS results in different scores, in varying domains, and not in a uniform way. For clinical use, we suggest it is preferable to err on the side of sensitivity. For research purposes, we recommend standardised use of birth-registered sex norms for current measures. We suggest developing universal non-gendered psychometric measures which rate psychological symptoms according to distress and functional impairment, resulting in a more inclusive, equitable framework for evaluating mental health in gender diverse populations.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 513-521"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143138849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social functioning and frontal alpha asymmetry in schizophrenia","authors":"Emily A. Farina ,&nbsp;Michal Assaf ,&nbsp;Silvia Corbera ,&nbsp;Jimmy Choi ,&nbsp;Christine Yantz ,&nbsp;Chi-Ming Chen","doi":"10.1016/j.jpsychires.2025.01.006","DOIUrl":"10.1016/j.jpsychires.2025.01.006","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia (SZ) is a psychiatric disorder that often involves reduced social functioning. Frontal alpha asymmetry (FAA) is a neurophysiological marker extracted from electroencephalogram (EEG) data that is likely related to motivational and emotional tendencies, such as reduced motivation across various psychiatric disorders, including SZ. Therefore, it may offer a neurophysiological marker for social functioning.</div></div><div><h3>Objectives</h3><div>The present study aimed to examine whether FAA is related to social functioning in schizophrenia. Additionally, a group of people with autism spectrum disorder (ASD) was included to explore whether findings are unique to schizophrenia, or whether they are found in another diagnostic group with atypical social behaviors.</div></div><div><h3>Methods</h3><div>Analysis of variance and regression models were used to evaluate data from resting-state EEG, clinical interviews, and self-report measures. Data from 33 participants with SZ were compared to 38 healthy controls and 30 individuals with ASD.</div></div><div><h3>Results</h3><div>Although people with SZ showed differences in FAA compared to healthy controls, the altered neurophysiology was not related to reduced social functioning in SZ. However, FAA was related to social functioning in people without a psychiatric diagnosis. Additionally, comparisons between the SZ and ASD group revealed few differences in patterns of FAA and social functioning, suggesting commonalities between the disorders in these areas.</div></div><div><h3>Conclusions</h3><div>FAA likely does not present a neurophysiological marker for reduced social functioning in schizophrenia, though future work should examine its role in other possible clinical manifestations shared between schizophrenia and ASD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 74-82"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health outcomes, associated factors, and coping strategies among LGBTQ adolescent and young adults during the COVID-19 pandemic: A systematic review","authors":"Chenglin Hong ,&nbsp;Bartosz Skiba","doi":"10.1016/j.jpsychires.2024.12.037","DOIUrl":"10.1016/j.jpsychires.2024.12.037","url":null,"abstract":"<div><div>LGBTQ adolescents and young adults have been disproportionately affected by the COVID-19 pandemic. This review aims to describe the impact of the COVID-19 crisis on mental health among LGBTQ adolescents and young adults, identify associated factors, and summarize coping strategies. A systematic review was conducted by searching six databases (PubMed, Embase, PsycINFO, CINAHL, Web of Science, MEDLINE). Eligibility criteria included (1) reported mental health outcomes, (2) conducted among LGBTQ adolescents and young adults, and (3) data collection occurred since January 2020. All studies were screened independently, and relevant data were synthesized following PRISMA guidelines. Of 395 records, 67 articles were screened for eligibility. Among these, 39 studies met the inclusion criteria. LGBTQ adolescents and young adults reported substantial mental health burdens, including depression, anxiety, stress, and loneliness during the pandemic. A pooled prevalence of depressive symptoms with a combined sample size of 7326 LGBTQ adolescents and young adults was 59% (95%CI: 0.48–0.70), (<em>I</em>^<em>2</em> = 98.95%, p &lt; 0.001). Among anxiety outcomes, the pooled prevalence with a sample size of 3258 LGBTQ adolescents and young adults was 55% (95% CI: 0.46–0.63), (<em>I</em>^<em>2</em> = 95.70%, p &lt; 0.001). Individual factors associated with mental distress included age, gender, and history of mental health disorders. Interpersonal and community-level factors included loss of safe spaces, family support, and discrimination on sexual and gender minority identity. Strategies to cope with distress include the use of social media and increased use of alcohol, tobacco, and other drugs. The pandemic has had a substantial negative impact on psychological distress among LGBTQ adolescents and young adults. Results substantiate the need for further research into social media as a coping instrument and the expansion of telehealth mental health services.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 132-141"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to letter to the editor: Evaluating the efficacy of zonisamide in managing alcohol use disorder","authors":"Laura J. Long,&nbsp;Daniella Spencer-Laitt,&nbsp;Bonnie Brown,&nbsp;Todd J. Farchione","doi":"10.1016/j.jpsychires.2024.11.059","DOIUrl":"10.1016/j.jpsychires.2024.11.059","url":null,"abstract":"","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 398-399"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}