中国居民SARS-CoV-2感染频率与抑郁症状：一个有调节的中介模型

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-06-24 DOI:10.1016/j.jpsychires.2025.06.033

Yuan You , Duo Zhang , Jin Yu , Yibo Wu , Lin Cai

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引用次数: 0

摘要

目的2019冠状病毒病（COVID-19）与抑郁症状相关，再次感染对心理健康构成风险。然而，很少有研究调查了严重急性呼吸综合征冠状病毒（SARS-CoV-2）感染频率对感知压力和抑郁症状的影响。本研究旨在研究SARS-CoV-2感染的频率是否与感知压力和随后的抑郁症状相关，并确定社会经济地位（SES）是否调节了这种中介作用。方法在本横断面研究中，于2023年6月20日至8月31日共招募了30,053名年龄在19-107岁的中国居民，其中男性15,011人，占49.9%。参与者回忆了他们感染SARS-CoV-2的频率。感知压力和抑郁症状通过感知压力量表-4和患者健康问卷-9进行测量。SES通过7分自我报告量表进行评估。进行了方差分析、方差分析和条件间接效应分析。结果一次SARS-CoV-2感染的居民抑郁症状少于未感染的居民。感知压力介导了一例SARS-CoV-2感染与抑郁症状减轻之间的关联，而较高的SESs放大了这种关联。相反，在多次感染的个体中，SARS-CoV-2感染的频率与抑郁症状的增加有关。结论在大流行后时期，反复感染SARS-CoV-2对居民心理健康仍有显著影响。应注意高危人群的心理压力和抑郁症状，如有反复感染史的个体。

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SARS-CoV-2 infection frequency and depressive symptoms in Chinese residents: A moderated mediation model

Objective

Coronavirus disease 2019 (COVID-19) is associated with depressive symptoms, with reinfection posing a risk to mental health. However, few studies have examined the impact of the frequency of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection on perceived stress and depressive symptoms. The present study aimed to examine whether the frequency of SARS-CoV-2 infection is associated with perceived stress and subsequent depressive symptoms and to determine whether socioeconomic status (SES) moderates this mediating effect.

Methods

In this cross-sectional study, a total of 30,053 Chinese residents (15,011 males, 49.9 %) aged 19–107 years were recruited between June 20 and August 31, 2023. The participants recalled their frequency of SARS-CoV-2 infection. Perceived stress and depressive symptoms were measured via the Perceived Stress Scale-4 and the Patient Health Questionnaire-9. SES was assessed via a 7-point self-report scale. MANOVA, ANOVA, and conditional indirect effect analysis were performed.

Results

Residents with one SARS-CoV-2 infection experienced fewer depressive symptoms than those with no infections. Perceived stress mediated the association between one case of SARS-CoV-2 infection and reduced depressive symptoms, with higher SESs amplifying this association. Conversely, among individuals with multiple infections, the frequency of SARS-CoV-2 infection was associated with increased depressive symptoms.

Conclusion

In the postpandemic era, repeated SARS-CoV-2 infections still significantly affect residents' mental health. Attention should be paid to the psychological stress and depressive symptoms of high-risk groups, such as individuals with a history of repeated infections.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;