Journal of periodontology最新文献

{"title":"Educational approaches to teach the 2017 periodontal classification to dental healthcare professionals: A scoping review","authors":"Srinivas Sulugodu Ramachandra, Ying S. Wang, Dimitris N. Tatakis, Jess Gurney","doi":"10.1002/jper.70180","DOIUrl":"https://doi.org/10.1002/jper.70180","url":null,"abstract":"Background Diagnostic errors are a major concern, particularly when long‐standing diagnostic criteria are updated. Following the 2017 World Workshop on the Classification of Periodontal and Peri‐implant Diseases and Conditions, a new classification was released in 2018. Subsequently, the dental community initiated steps to teach the updated classification to dental healthcare professionals. This scoping review aimed to identify the different educational approaches used to teach the 2017 periodontal classification. Methods English language articles, published between 2018 and April 2026, reporting on an educational approach to teach the 2017 periodontal classification were searched in MEDLINE, Scopus, Web of Science, and Google Scholar. Results From a total of 1487 articles initially screened, 28 selected articles were subjected to full‐text review, and 18 articles were included in this scoping review. The educational approaches used to teach the 2017 periodontal classification were lectures with case‐based scenarios, blended learning, team‐based learning, flipped classroom, flowcharts, algorithms, calibration sessions, a mobile application, and software applications. These educational approaches were classified into theoretical, applied clinical, and technology‐assisted applied clinical approaches. For flowcharts and algorithms, randomized controlled trials have been conducted to validate their educational benefit. Several of the educational approaches were associated with improved diagnostic accuracy among dental healthcare professionals of varying expertise and training. Conclusion Various educational approaches have been used to teach the 2017 periodontal classification, with potential benefits for diagnostic accuracy and trainee confidence. However, further research is needed to better define their impact on periodontal diagnosis and clinical practice. Plain language summary Updating diagnostic systems can lead to errors, which makes effective training important. After a new periodontal disease classification was introduced in 2018, educators developed different ways to teach it to dental health care professionals. This review examined those teaching methods. After searching major databases for English‐language studies, 1,487 articles were initially identified and, ultimately, 18 were included in the final review. There was a wide range of methods used to teach the 2017 periodontal classification and included lectures with case scenarios, blended and flipped learning, team‐based learning, flowcharts, decision‐making algorithms, calibration sessions, and mobile or software applications. Some methods, particularly flowcharts and decision‐making algorithms, have been tested in clinical trials and have been shown to improve learning. Overall, several approaches were associated with the improved ability of clinicians to make accurate diagnoses, regardless of their level of experience. These findings suggest that various strategies are available to","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"50 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demineralized bone allograft fibers versus particulate in sinus augmentation: A double‐arm randomized controlled and histomorphometric study","authors":"Kathryn Gabel, Brian L. Mealey, Michael Mills, Archontia A. Palaiologou","doi":"10.1002/jper.70174","DOIUrl":"https://doi.org/10.1002/jper.70174","url":null,"abstract":"Background The primary aim of this study was to evaluate histologic wound healing of demineralized freeze‐dried bone allograft (DFDBA), in particulate (P) or fiber (F) form, in combination with deproteinized bovine bone mineral (DBBM) for maxillary sinus floor augmentation. Two stains were used to evaluate whether the type of stain had an effect on histologic analysis. Methods This two‐arm, parallel, randomized controlled trial included 29 patients with maxillary posterior edentulism requiring maxillary sinus augmentation to facilitate implant placement. Patients were blindly randomized into one of two groups: DBBM+F or DBBM+P. After 6 months of healing, bone cores were collected for histologic evaluation of vital bone, residual allograft, residual xenograft, and connective tissue (CT)/other using two stains (hematoxylin and eosin [H&amp;E] and Masson's trichrome). Results No statistically significant differences were observed between the DBBM+F and DBBM+P groups for percent vital bone formation, residual graft, or CT/other on mixed linear model analysis (all <jats:italic>p</jats:italic> &gt; 0.05). Paired analysis demonstrated no statistically significant differences between H&amp;E and trichrome staining for percent vital bone formation, residual allograft, or residual xenograft (all <jats:italic>p</jats:italic> &gt; 0.05). However, a statistically significant difference was observed for CT/other, with trichrome staining yielding lower mean values than H&amp;E (mean paired difference −8.03%, <jats:italic>p</jats:italic> = 0.0146). Conclusion Both graft combinations demonstrated comparable histomorphometric outcomes within the limits of this study. Masson's Trichrome staining may improve discrimination between osteoid/collagen matrix and mineralized tissue interfaces during histomorphometric analysis.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"46 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eubiosis and dysbiosis in periodontitis‐related systemic diseases","authors":"Rajesh Kanna Gopal, Naji Naseef Pathoor, Pitchaipillai Sankar Ganesh","doi":"10.1002/jper.70188","DOIUrl":"https://doi.org/10.1002/jper.70188","url":null,"abstract":"Background This narrative review examines the eubiosis‐dysbiosis spectrum in periodontitis and its systemic implications. Evidence is drawn from the literature through 2026; as a narrative review, some selection bias cannot be excluded. Periodontitis, affecting 10%–15% of adults globally, drives systemic health disorders through microbial dysbiosis. Objectives This narrative review examines microbial ecological shifts in periodontitis and their implications for cardiovascular disease (CVD), diabetes mellitus (T2D), neurodegenerative disorders, rheumatoid arthritis (RA), and other systemic conditions. Methods We have synthesized the current evidence on oral microbiome transitions from eubiosis to dysbiosis, focusing on mechanistic pathways linking periodontal disease to systemic health outcomes. Results Periodontal dysbiosis may influence systemic health through mechanisms including bacteremia, chronic inflammation, molecular mimicry, and microbiome axis interactions. Individuals with periodontitis show 1.5 to 2‐fold increased cardiovascular risk, bidirectional relationships with diabetes (HbA1c reductions of 0.3%–0.5% following periodontal treatment), and associations with Alzheimer's disease, rheumatoid arthritis, and inflammatory bowel disease. Key pathogens including <jats:italic>Porphyromonas gingivalis</jats:italic> , <jats:italic>Aggregatibacter actinomycetemcomitans</jats:italic> , and <jats:italic>Fusobacterium nucleatum</jats:italic> have been proposed as keystone species capable of remodeling microbial communities and potentially contributing to systemic effects. Conclusions Understanding the eubiosis‐dysbiosis spectrum provides crucial insights into oral‐systemic health connections and offers therapeutic targets for managing both periodontal and systemic diseases. Integrated medical‐dental care approaches, precision medicine strategies, and microbiome‐based therapeutics represent promising future directions.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"116 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two‐ to six‐year outcomes of tunnel technique with connective tissue graft in multiple mandibular anterior recessions","authors":"Zi‐Yun Xiong, Li Chen, Qiu‐Yang Yu, Qin Xiong, Hui‐Nan Wu, Shuo‐Yan Wu, Wei‐Qian Wang, Dong‐Ying Xuan","doi":"10.1002/jper.70183","DOIUrl":"https://doi.org/10.1002/jper.70183","url":null,"abstract":"Background The purpose of this study is to report the 2–6 year outcomes of the tunnel technique with a connective tissue graft (TUN+CTG) in treating multiple Cairo recession type 1 and 2 recessions over a 2–6 year follow‐up, and the influence of CTG exposure on treatment effects. Methods Seventeen patients with 73 multiple recession sites were treated with TUN+CTG (27 of RT1 vs. 46 of RT2). A total of 32 sites exhibited CTG exposure. The average extent of exposure was 2.21 ± 0.95 mm. The recession depth (RD), keratinized gingival width (KGW), percentage of root coverage (RC), percentage of complete root coverage (CRC), root exposure score (RES), and mucosal scarring index (MSI) were assessed at 6 months and 2–6 year follow‐up. Results At 6 months, the mean RC was 86.92% and the CRC was 69.86%; After 2–6 years, the mean RC was 84.49% and the CRC was 63.01%. The KGW increased significantly (1.82 mm). There was a considerable difference of CRC at 2–6 years between RT1 and RT2 defects (74.07% vs. 56.52%), which did not reach statistical significance. There was a statistically significant reduction of CRC in RT2 defects from 6 months to 2–6 year follow‐up (from 67.39%–56.52%). Both the RES and the MSI score reached a high esthetic value in all sites. No statistical difference was observed in terms of RC, CRC, and KGW gain between the CTG partial‐exposed sites and full‐covered sites, except for the RES and the MSI score. Conclusions In the mandibular anterior region, multiple RT1 and 2 gingival recessions could be treated successfully by the TUN+CTG procedure with relative long‐term stable clinical and esthetic effects. A partially exposed CTG does not appear to compromise the treatment outcomes. Plain language summary Gum recession is a highly prevalent dental problem, most frequently affecting the lower front teeth. The tunnel technique is a modern surgical approach that treats gum recession. It preserves the blood supply to the gums by carefully lifting them without cutting the small triangles of gum tissue between the teeth. Underneath the lifted gum tissue, a gum graft that is usually taken from the roof of the mouth is placed. There is limited evidence about the long‐term effects of the above techniques in treating multiple recessions on the lower front teeth. Additionally, in some cases, a small portion of the gum graft may remain exposed after surgery. Whether this exposure affects the treatment result was controversial. In this study, 17 patients with 73 recession sites were treated and followed for 2 to 6 years. We found that 84.5% of the exposed tooth roots were covered by gum tissue. In some cases, a small part of the graft was intentionally left visible to help create a more natural‐looking gum line. It did not harm the treatment outcome. This study provided practical, evidence‐based guidance for optimizing both functional and esthetic outcomes in periodontal plastic surgery of the lower front dentition.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"61 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of corn syrup consumption on bone and inflammatory parameters in rats with spontaneous periodontitis","authors":"Valbiana C. M. Abreu‐Araujo, Maryana F. Praseres, Rebeca B. Mendonça, Carolina O. Lima, Joicy C. S. Sousa, Lidio G. Lima‐Neto, Nathalya dos S. Martins, Emmanuel J. N. L. Silva, Renato C. V. Casarin, Vandilson P. Rodrigues, Cecília C. C. Ribeiro, Luciana S. Branco‐de‐Almeida","doi":"10.1002/jper.70186","DOIUrl":"https://doi.org/10.1002/jper.70186","url":null,"abstract":"Background Although added sugar consumption is associated with altered periodontal parameters in humans and alveolar bone loss in rodents, the immunoinflammatory pathways involved and the links between local periodontal and systemic effects are not yet defined. The purpose of this study was to evaluate the effect of chronic corn syrup (CS) consumption on alveolar bone loss, bone microstructure, and local/systemic inflammatory parameters in rats. Methods Male Wistar rats ( <jats:italic>n</jats:italic> = 8 per group) were divided into two groups: Control — standard diet and water ad libitum; CS — standard diet and 20% corn syrup for 12 h per day for 12 weeks. Alveolar bone loss was assessed by radiography, and bone microstructure of right hemimandibles and left femurs by micro‐computed tomography (micro‐CT). Interleukin (IL)‐1β, IL‐6, IL‐17, and tumor necrosis factor (TNF)‐α cytokines were measured in gingival tissue and plasma. Periodontal, liver, and kidney inflammation were evaluated histologically. Results The CS group consumed less food and more liquid ( <jats:italic>p</jats:italic> &lt; 0.05) and showed greater alveolar bone loss along with reduced alveolar trabecular number ( <jats:italic>p</jats:italic> &lt; 0.05), with no changes in femoral microstructure ( <jats:italic>p</jats:italic> &gt; 0.05). Gingival TNF‐α and IL‐17 levels were higher in the CS group ( <jats:italic>p</jats:italic> &lt; 0.05). Histologically, the CS group showed increased periodontal inflammatory infiltrate and more osteoclasts in the periodontal ligament. No differences were found between groups in plasma cytokines and liver or kidney histology. Conclusion High CS consumption aggravated spontaneous periodontitis in rats, resulting in alveolar bone loss and increased gingival inflammatory cytokines, with no changes in the systemic parameters evaluated over the study period.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"51 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of periodontitis and risk of ischemic stroke: A systematic review and meta‐analysis","authors":"Steven Sitt, Chloe J. Chang, Chin‐Wei Wang","doi":"10.1002/jper.70185","DOIUrl":"https://doi.org/10.1002/jper.70185","url":null,"abstract":"Background Periodontitis is a prevalent chronic inflammatory disease with a systemic inflammatory burden and is implicated with vascular pathology. This systematic review and meta‐analysis evaluates the association between varying severities of periodontitis and ischemic stroke with various diagnostic criteria. Methods Following PRISMA 2020 (PROSPERO:1161816), PubMed (MEDLINE), Web of Science, and Scopus were searched from January 2000 to January 2026. Studies with clinically or radiographically diagnosed adult periodontitis patients were included. Studies reporting hazard ratios (HRs) and odds ratios (ORs) for ischemic stroke or cardiovascular outcomes with clear diagnosis and outcome definition were considered eligible. Study characteristics, diagnosis methods, periodontitis severity, outcomes, outcome ascertainment, follow‐up duration, effect measures with 95% confidence intervals, and adjustment variables were extracted. The study quality was assessed using the Newcastle–Ottawa Scale (NOS). Results Fifteen studies met the inclusion criteria: seven cohorts and eight case–controls. Pooled estimates showed an increased risk of ischemic stroke with periodontitis (HR = 1.24; 95%CI, 1.11–1.38; OR = 4.59; 95%CI, 1.81–11.62). Subgroup analysis revealed that severe periodontitis (OR = 4.19; 95%CI, 3.14–5.59) confers a greater risk than moderate disease (OR = 1.63; 95%CI, 1.16–2.29). New classification diagnostic criteria (AAP/EFP, CDC/AAP) produced stronger associations, OR = 5.35 (95%CI, 3.35–8.55), and a longer follow‐up (≥ 15 years) amplified the risk (HR = 1.80; 95%CI, 1.33–2.44), supporting temporality. Conclusions Severe periodontitis is significantly associated with ischemic stroke, with a consistent severity‐related trend across studies. Therefore, meticulously diagnosed advanced periodontitis should be considered as a probable vascular risk factor and should prompt interdisciplinary management and patient education. Plain language summary Gum disease (periodontitis) is a very common long‐term inflammatory disease that affects the supporting tissue of the teeth. Increasing evidence suggests that periodontitis may also influence the general health of a person. In this study we focused particularly on ischemic stroke, the most common type of stroke. We analyzed data from multiple long‐term research studies to determine if the severity of gum disease influences the risk of a person developing ischemic stroke. We found that the severe form of gum disease is significantly associated with ischemic stroke risk compared with individuals with healthy gums or a milder form of gum disease. This association is stronger in studies that used standardized diagnostic criteria and in studies with longer follow‐up periods. This suggests that a systematically diagnosed severe gum disease is most likely to contribute to stroke development over time. These findings highlight the importance of early detection to properly manage gum disease. Closer collaboration bet","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"22 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148729162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal status in an older population: An 18‐year longitudinal comparative study","authors":"Sladjana Critén, Pia Andersson, Stefan Renvert, Johan Sanmartin Berglund, Bengt Götrick, Viveca Wallin Bengtsson","doi":"10.1002/jper.70184","DOIUrl":"https://doi.org/10.1002/jper.70184","url":null,"abstract":"Background The prevalence of periodontitis increases with aging. The present study aimed to assess descriptively the changes in periodontal status over an 18‐year period among individuals aged 60 and 66 years at baseline who participated in the Swedish National Study on Aging and Care in Karlskrona, Sweden. Methods This longitudinal study used quantitative methods based on data from the ongoing project, The Swedish National Study on Aging and Care (SNAC) in Karlskrona, Sweden. A total of 340 individuals aged 60 and 66 years underwent periodontal and radiographic examinations at baseline (2001–2003). Follow‐up assessments were conducted after 12 years (2013–2015; <jats:italic>n</jats:italic> = 217) and after 18 years (2019–2021; <jats:italic>n</jats:italic> = 79). A paired <jats:italic>t</jats:italic> ‐test, McNemar's test, and binary logistic regression were performed for the statistical analysis. Statistical significance was determined at <jats:italic>p</jats:italic> &lt; 0.05. Results Overall, the mean value BOP (SD) increased from 19.71(17.6) % at baseline to 32.73 (21.7) % at the 18‐year follow‐up (Cohen's <jats:italic>d </jats:italic> = ‒0.57; 95%CI: ‒0.81 to ‒0.33; <jats:italic>p</jats:italic> &lt; 0.001). The proportion of participants with at least one site exhibiting a bone level ≥ 5 mm increased significantly, from 49.4% at baseline to 88.6% at the 18‐year follow‐up, corresponding to an absolute increase of 39.2 percentage points ( <jats:italic>p</jats:italic> &lt; 0.001). In addition, the prevalence of periodontitis increased from 7.8% to 19.5% over the same period, an absolute increase of 11.7 percentage points ( <jats:italic>p</jats:italic> = 0.035). Conclusions The present study indicates that periodontal status deteriorates over 18 years among participants aged 60 and 66 years at baseline. Plain language summary This study followed an older population over an 18‐year period to describe how their periodontal status (gum conditions, periodontal pocket depth, and alveolar bone levels) changed over time. The participants were part of the Swedish National Study on Aging and Care in Karlskrona, Sweden. A total of 340 individuals who were 60 or 66 years old at the start (2001–2003) were included. They underwent periodontal and radiographic (x‐ray) examinations at baseline and again after 12 years (2013–2015) and 18 years (2019–2021). Over time, periodontal status worsened, with more inflammation, more bone loss around the teeth, and a higher proportion of individuals classified as having periodontitis according to the definition used in this study.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"36 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148729163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis and gastric disorders: Systematic review and meta‐analysis of functional dyspepsia and Helicobacter pylori gastritis","authors":"Hadeel Mohammed Abbood, Jasim Mohammed Abbood, Ekin Yay‐Kus, Iain L. C. Chapple","doi":"10.1002/jper.70177","DOIUrl":"https://doi.org/10.1002/jper.70177","url":null,"abstract":"Background Periodontitis has been associated with other systemic inflammatory diseases, such as cardiovascular disease, diabetes mellitus, and rheumatoid arthritis; through the translocation of oral bacteria and local inflammatory mediators systemically. Establishing potential associations between periodontitis and gastric disorders may contribute to the prevention and management of both conditions. This study has three aims: Aim 1, investigate associations between functional dyspepsia and periodontitis; Aim 2, assess the association between gastric &lt;jats:italic&gt;Helicobacter pylori&lt;/jats:italic&gt; and periodontitis; Aim 3, evaluate the effect of periodontal treatment on the eradication of gastric &lt;jats:italic&gt;H. pylori&lt;/jats:italic&gt; . Methods Medline, EMBASE, other databases, and Google Scholar were electronically searched during March 2026. All observational and trial studies conducted on adult humans were selected. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was employed to assess the overall body of evidence. The Newcastle–Ottawa Scale and the Risk of Bias2 tool were applied to assess risk of bias in the included studies. Meta‐analysis was conducted using Review Manager 5.4. Results Fourteen papers were selected. Most studies demonstrated an association between periodontitis and various gastric problems. Meta‐analysis for aims 2 and 3 showed an association between periodontitis and gastric &lt;jats:italic&gt;H. pylori&lt;/jats:italic&gt; , pooled odds ratio (POR) = 1.66 (95% confidence interval [CI] 1.22–2.27). Additionally, a positive effect of combining periodontal and systemic therapy on complete eradication of &lt;jats:italic&gt;H. pylori&lt;/jats:italic&gt; was observed, POR = 2.94 (95% CI 1.15–7.51). Conclusion An association between periodontitis and several gastric disorders, particularly &lt;jats:italic&gt;H. pylori&lt;/jats:italic&gt; gastritis has been demonstrated. Moreover, adding non‐surgical periodontal treatment to the standard systemic antibiotic regimen showed to enhance eradication of gastric &lt;jats:italic&gt;H. pylori&lt;/jats:italic&gt; . Future research is needed. Plain language summary Gum disease, particularly periodontitis, is linked to other health problems, such as diabetes, heart disease, and rheumatoid arthritis. This review looked at whether there is a link between gum disease and stomach disorders. Three aims were set: Aim 1, to look at the possible connection between gum disease and indigestion (functional dyspepsia); Aim 2, to look at the possible connection between gum disease and stomach infection with &lt;jats:italic&gt;Helicobacter pylori&lt;/jats:italic&gt; ; and Aim 3, to see if treating gum disease can help clear stomach infection if combined with the standard stomach infection treatment with antibiotics. Medical databases were searched for relevant studies up to March 2026. As a result, 14 studies were included. Most of these included studies showed a connection between gum disease and stomach infection (odds ratio 1.66)","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"6 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148729183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post‐surgical infections: Prevalence associated with various periodontal surgical procedures","authors":"Camille N. Banson, Archontia Palaiologou, Brian L. Mealey, Kerri Font, Charles A. Powell","doi":"10.1002/jper.70179","DOIUrl":"https://doi.org/10.1002/jper.70179","url":null,"abstract":"Background This retrospective study aimed to assess the prevalence of postoperative infections after periodontal and implant surgical therapy and examined the treatment variables that may affect infection prevalence. Methods A retrospective review on patients who were surgically treated in the graduate periodontics clinic at the University of Texas at San Antonio School of Dentistry was performed. Surgeries included osseous surgery, extractions, alveolar ridge preservation, guided tissue regeneration, implant placement, treatment of peri‐implantitis, guided bone regeneration, crestal and lateral sinus augmentation, and mucogingival surgery. Postoperative infections that occurred within the first 2 weeks of healing were recorded. Postoperative infection prevalence was compared between procedures with and without specific treatment variables (e.g., bone grafts, biologics, membranes, antibiotics, chlorhexidine rinse, surgical dressing). Results Of the 18,505 procedures included in this study, 217 had postoperative infections resulting in an overall infection prevalence of 1.17% at the procedure‐level. The prevalence varied from 0–5% based on procedure type, with guided bone regeneration demonstrating the highest prevalence. On a patient‐level 176 patients experienced at least one postoperative infection, resulting in a patient‐level infection prevalence of 4.06% (95%CI, 3.51%–4.69%). The Random Forest Model showed the use of biologics and antibiotics correlated with increased infection prevalence; however, these agents were generally utilized for more complex surgeries with an inherently greater risk of infection. Bone grafts, membranes, and chlorhexidine prescription did not show a major influence on infection prevalence. Conclusions The post‐surgical infection prevalence of periodontal surgery is low. These findings do not support the routine use of perioperative antibiotics as a preventive measure for infections. Rather than implementing routine administration, clinicians must evaluate the necessity of post‐surgical antibiotic therapy on an individual basis. This assessment should comprehensively account for the patient's medical history, the specific surgical procedure, the complexity of the treatment, and the incorporation of biomaterials. Prospective studies are needed to elucidate the role antibiotics and biomaterials have on post‐surgical infections.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"32 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148729185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological activation of GPR120 ameliorates diabetic periodontitis in mouse models through suppression of NET-associated responses.","authors":"Chao Jiang, Yilin Shi, Biwen Yao, Kedie Zhang, Yifan Yin, Zhiyi Zhu, Shuhui Tang, Jianying Feng, Mengfei Yu, Shan Wang","doi":"10.1002/jper.70191","DOIUrl":"https://doi.org/10.1002/jper.70191","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological studies show periodontitis and type 2 diabetes share a bidirectional aggravating relationship, yet the molecular mechanisms linking systemic metabolic dysregulation to local periodontal destruction remain unclear, and effective therapies for this comorbidity are lacking. Certain G protein-coupled receptors (GPCRs) enhance insulin secretion and attenuate inflammation. We hypothesized that GPCR regulators may contribute to crosstalk between systemic metabolic abnormalities and periodontal immunopathology.</p><p><strong>Methods: </strong>Using db/db mice with ligature-induced periodontitis, we performed multi-tissue transcriptomics of gingiva, colon, and small intestine combined with weighted gene co-expression network analysis (WGCNA) to identify GPCR-related candidates. The selective G protein-coupled receptor 120 (GPR120) agonist TUG-891 was administered to evaluate therapeutic effects on metabolic parameters and alveolar bone loss. In vivo and in vitro experiments, including gingival tissue immunofluorescence, PicoGreen dsDNA quantification, and western blotting were used to assess NET- and NLRP3-related responses.</p><p><strong>Results: </strong>WGCNA identified GPR120 as a shared GPCR-related candidate across three tissues in diabetic periodontitis, with upregulation confirmed in gingiva. TUG-891 partially alleviated hyperglycemia, dyslipidemia, and alveolar bone loss. GPR120 activation reduced NET-associated signals in vivo and in vitro, downregulated calcium/potassium signaling (upstream NLRP3 activators), and decreased LPS/glucose-induced upregulation of NLRP3 and ASC in neutrophils. The NLRP3 inhibitor MCC950 phenocopied, while the NLRP3 activator nigericin reversed, the NET-associated changes of TUG-891.</p><p><strong>Conclusions: </strong>This study identifies GPR120 as a factor associated with metabolic stress and periodontal destruction in diabetic periodontitis, and suggests that the signaling involving GPR120, NLRP3-related responses, and NET-associated inflammation may hold therapeutic potential for this common diabetic complication.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}