Journal of periodontology最新文献

{"title":"RETRACTION: Effect of Porphyromonas gingivalis Lipopolysaccharide on Bone Marrow Mesenchymal Stem Cell Osteogenesis on a Titanium Nanosurface.","authors":"","doi":"10.1002/jper.70148","DOIUrl":"https://doi.org/10.1002/jper.70148","url":null,"abstract":"<p><strong>Retraction: </strong>H. Xing, Y. Taguchi, S. Komasa, I. Yamawaki, T. Sekino, M. Umeda, J. Okazaki \"Effect of Porphyromonas gingivalis Lipopolysaccharide on Bone Marrow Mesenchymal Stem Cell Osteogenesis on a Titanium Nanosurface,\" Journal of Periodontology 86, no. 3 (2015): 448-455, https://doi.org/10.1902/jop.2014.140386 The above article, published online on 01 March 2015 in the Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement among journal Editor-in-Chief, Dr. Effie Ioannidou; the American Academy of Periodontology; and John Wiley & Sons, Inc. The President of Osaka Dental University contacted the Editor-in-Chief and editorial staff of the Journal of Periodontology requesting the retraction. A research integrity committee from the University concluded that the authors committed research misconduct by using identical data and figures that had been published previously. The Editor-in-Chief reviewed the articles in question and concluded that in the present article, Table 1 data in the titanium (Ti) control group and the titania nanosheet (TNS) control group present completely identical data, in different experimental conditions, to a previously published International Journal of Nanomedicine article [Xing et al. (2014); https://doi.org/10.2147/IJN.S58502], that has since been retracted. Several images in Figure 1 are also identical to images published in Xing et al. (2014). Additionally, in the present article, Figures 3A and 3B showing cell cultures include identical image parts in different experiments and groups; Figures 4A and 4B showing cell cultures also present visibly identical images in different experiments and groups. The corresponding author could present neither the original raw data nor the correct images as requested by the University. The University requested that the corresponding author retract the article but did not receive a response. Dr. Xing does not agree with the retraction. Dr. Komasa agrees with the retraction. No response was received from Drs. Taguchi, Yamawaki, and Sekino, and Drs. Umeda and Okazaki could not be reached. This retraction notice is being published in both the print and online versions of the Journal of Periodontology.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":"e70148"},"PeriodicalIF":3.8,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic analysis of gingival tissues in resolved experimental periodontal lesions of nonhuman primates.","authors":"Jeffrey L Ebersole, Sreenatha S Kirakodu, Octavio A Gonzalez","doi":"10.1002/jper.70048","DOIUrl":"https://doi.org/10.1002/jper.70048","url":null,"abstract":"<p><strong>Background: </strong>This study used a preclinical model of experimental periodontitis in nonhuman primates to evaluate the biological features of resolved periodontal lesions.</p><p><strong>Methods: </strong>Macaca mulatta (rhesus monkeys) were age-stratified into young [≤3 years (7-10-year-old humans)], adolescent/young adult [3-7 years (12-25-year-old)], adults [12-15 years (40-50-year-old)], and aged [17-23 years (60-80-year-old)]. The samples were also analyzed based on sex or matrilineal derivation. The gingival transcriptome was evaluated using microarray analyses on tissue biopsies from healthy tissues and at resolution (i.e., clinical improvement).</p><p><strong>Results: </strong>Resolution sites showed clinical improvement, as well as patterns of increased or decreased gene expression in resolution versus healthy tissues in all age groups. These differences represented a large array of adaptive immune genes that were elevated in resolution, with decreased metabolic, regulatory, structural, and transcription factor gene expression in the resolution samples. Many of these genes were common to all age groups or sex/matriline, thus suggesting some fundamental core profile of affected genes that discriminate healthy from lesion resolution tissues.</p><p><strong>Conclusions: </strong>Irrespective of age, the biology of periodontal lesion resolution tissues is distinct from healthy tissues. Despite a robust inflammatory response to the ligature-induced microbiome changes during experimental periodontitis, younger individuals showed significantly less destructive disease and different transcriptome profiles that could reflect improved lesion resolution. While sex and matriline affected the gene expression patterns, these generally overlapped with the prominent genes identified for resolution versus health across age groups. Highly affected genes could be considered biomarkers for resolved tissues, linking clinical and biological resolution of periodontal lesions.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between adverse childhood experiences and periodontitis in young adults.","authors":"Hantao Huang, Mengxi Zhai, Guangxun Zhu","doi":"10.1002/jper.70144","DOIUrl":"https://doi.org/10.1002/jper.70144","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis, a chronic inflammatory disease, is increasingly prevalent among young people and impairs their quality of life. Adverse childhood experiences (ACE), depressive symptoms, and suboptimal health status (SHS) are linked to health risks and chronic diseases, but their interrelationships with periodontitis in Chinese young adults remain unclear. This study aimed to explore associations among these factors.</p><p><strong>Methods: </strong>From December 2024 to May 2025, 2,888 participants (aged 18-35) from Tongji Hospital completed surveys on demographics, ACE, depressive symptoms, and SHS. Periodontitis was diagnosed according to the 2018 criteria. Simple, parallel, and chain mediation models were used, controlling for age, sex, marital status, and smoking.</p><p><strong>Results: </strong>Periodontitis prevalence was 25.00% and higher in married individuals (P < 0.001) and smokers (P = 0.004). ACE correlated positively with depressive symptoms (r = 0.28, P < 0.001), SHS (r = 0.19, P < 0.001), and periodontitis (r = 0.16, P < 0.001). Mediation analyses showed: Simple model: Depressive symptoms and SHS partially mediated the effect of ACE on periodontitis (indirect effect = 0.011 for both). Parallel model: Only SHS significantly mediated the effect (indirect effect = 0.011). Chain model: ACE was related to periodontitis via \"depressive symptoms → SHS\" (indirect effect = 0.010), with significant direct and indirect effects.</p><p><strong>Conclusions: </strong>ACE associated with higher periodontitis risk in young people. This association included both a direct link between ACE and periodontitis, and an indirect link through the chain pathway of \"depressive symptoms → SHS\"; among these pathways, SHS was a key mediator.</p><p><strong>Clinical trial registry: </strong>The study was registered in the Chinese Clinical Trial Registry (ChiCTR) with the registration number ChiCTR2500103464.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning cone-beam computed tomography image segmentation for the 3D visualization of mandibular infraosseous periodontal defects.","authors":"Daniel Palkovics,Balint Molnar,Csaba Pinter,David García-Mato,Andres Diaz-Pinto,Attila Tanacs,Andrea Dobos,Peter Windisch,Christoph A Ramseier","doi":"10.1002/jper.70058","DOIUrl":"https://doi.org/10.1002/jper.70058","url":null,"abstract":"BACKGROUNDThe accurate assessment of infraosseous periodontal defects is crucial for effective diagnosis and treatment planning. Cone-beam computed tomography (CBCT) enables detailed imaging of these defects; however, to leverage their full potential, CBCT images must be reconstructed in 3 dimensions (3D). Manual and semi-automatic (SA) segmentation methods are time-consuming and prone to human error. This study aimed to evaluate the performance of a deep learning (DL) model in segmenting mandibular infraosseous periodontal defects on CBCT scans.METHODSA multi-stage Segmentation Residual Network (SegResNet)-based DL model was used to segment CBCT scans from patients with stages III to IV periodontitis. Linear and volumetric measurements of infraosseous defects from DL-generated 3D models were compared to those obtained using SA segmentation. The depth (INFRA), width (WIDTH), angle (ANGLE), and volume of 48 infraosseous defects were assessed on both DL and SA segmentations.RESULTSMeasurements made on the DL and SA segmentations correlated strongly. The intraclass correlation coefficient (ICC) was 0.941 (p < 0.0001) for INFRA, 0.943 (p < 0.0001) for WIDTH, 0.889 (p < 0.0001) for ANGLE, and 0.948 (p < 0.0001) for defect volume. These results indicate high reliability of the DL model in capturing key characteristics of infraosseous periodontal defects.CONCLUSIONSThese findings support the use of DL-based CBCT segmentation as a valuable tool for enhancing periodontal diagnosis. However, as this study was limited to mandibular defects, applicability to maxillary cases remains to be validated.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"249 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding peri-implantitis occurrence and recurrence following treatment: A patient-centered study.","authors":"Alberto Monje,Manal Sarsri Reffassi,Cristina Vallés,Ilyes Gourdache,Purnima Kumar,José Nart","doi":"10.1002/jper.70133","DOIUrl":"https://doi.org/10.1002/jper.70133","url":null,"abstract":"BACKGROUNDThe present study aimed at gaining insight on patients´ perception of peri-implantitis and its treatment and also to explore the effect of treatment outcome on patients´ perception and satisfaction.METHODSPatients who had received peri-implantitis treatment were contacted and invited to participate in the questionnaire-based survey. Overall, 30 items were surveyed, including demographics, data concerning implant placement, diagnosis and signs/symptoms of peri-implantitis, level of education of disease, risk factors, knowledge of factors implicated in disease recurrence, and treatment delivered along with its self-perceived outcomes. Moreover, the treatment outcome was further recorded. Descriptive analyses and correlation tests were applied to explore association.RESULTSBased on an a priori sample size calculation, 100 patients with 258 implants subjected to peri-implantitis treatment were included. In total, 63% of the patients successfully responded to therapy displaying arrest in progressive bone loss, 26% demonstrated progressive bone loss (≥ 1 mm) and 11% were subjected to implant removal. The overall level of knowledge about peri-implantitis was moderately low, where ∼ 60% of the patients surveyed reported null knowledge about diagnosis, prevalence, or risk factors associated with disease occurrence, despite having received treatment of this disease. Compliers with supportive care demonstrated greater level of concern and knowledge regarding peri-implantitis and its recurrence. Patients were overall satisfied immediately (following therapy), at early (re-evaluation), and at late stages (during follow-up) with therapeutic outcomes of peri-implantitis, despite the therapeutic outcome achieved. In addition, patients accepted the possibility of disease recurrence and their role in minimizing it.CONCLUSIONPatient-reported information on factors related to peri-implantitis occurrence and recurrence is suboptimal. Nearly 60% of the patients are unaware of factors related to peri-implantitis ocurrence. However, peri-implantitis therapy does not seem to negatively interfere in the patients´ quality of life or satisfaction, despite the treatment outcomes.PLAIN LANGUAGE SUMMARYThis study examined how patients understand peri-implantitis and how they feel about its treatment. One hundred patients who received peri-implantitis therapy completed a questionnaire, and treatment outcomes were evaluated using x-rays. Most patients had limited knowledge about peri-implantitis, its causes, and risk factors, even after treatment. Patients who attended regular follow-up care showed greater awareness of the disease. Despite differences in treatment outcomes, including ongoing bone loss or implant removal, patients were generally satisfied with their treatment and accepted the possibility of disease recurrence. These findings highlight the need for better patient education, while showing that peri-implantitis treatment does not negatively affect patient ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"5 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degraded trabecular bone score and periodontitis progression: 5-year cohort with increased risk in postmenopausal women.","authors":"Chaivasan Malakam,Attawood Lertpimonchai,Chanika Sritara,Piyamitr Sritara,Orawan Charatkulangkun,Nisakron Thongmung,Sanutm Mongkornkarn","doi":"10.1002/jper.70126","DOIUrl":"https://doi.org/10.1002/jper.70126","url":null,"abstract":"BACKGROUNDNo longitudinal evidence exists linking the trabecular bone score (TBS), a novel index of bone quality, to periodontitis. This 5-year retrospective cohort study explored the relationship between TBS and periodontitis progression in the Electrical Generating Authority of Thailand (EGAT) population, with a focus on postmenopausal women.METHODSBaseline mean TBS values of 617 participants aged 30-80 years were assessed from dual-energy x-ray absorptiometry (DXA) images of L1-L4 lumbar spines and classified as normal, partially degraded, or degraded TBS groups. At baseline and at 5-year follow-up surveys, the participants received full-mouth periodontal examinations. Periodontitis progression was defined as an additional ≥3 mm loss of proximal clinical attachment level (CAL) or the loss of a tooth with a baseline proximal CAL of ≥5 mm. Changes in periodontal parameters among the TBS groups were analyzed using the Kruskal-Wallis and Mann-Whitney U tests. The effects of TBS status on periodontitis progression were analyzed using multivariate Poisson regression.RESULTSCompared with the normal TBS group, participants with degraded TBS had a higher median number of teeth with periodontitis progression-approximately one additional tooth in the entire study population and two additional teeth in postmenopausal women. In the postmenopausal subgroup, degraded TBS was associated with a higher number of teeth with periodontitis progression, with an adjusted risk ratio of 1.85 (95% CI: 1.22-2.81).CONCLUSIONSDegraded TBS is associated with an increased number of teeth with periodontitis progression in postmenopausal women. Early diagnosis and interdisciplinary collaboration between dental and medical professionals may help to mitigate progression in this population.PLAIN LANGUAGE SUMMARYGum disease (also called periodontitis) is a long-term condition that damages the tissues and bone supporting the teeth. Poor bone quality may be associated with an increased risk of gum disease progression. Bone quality can be measured using the trabecular bone score (TBS), which reflects the structural characteristics of bone rather than bone density. This study followed 617 Thai adults over 5 years to assess the link between bone quality and worsening gum disease. Disease progression was defined as a major loss of tooth support or the loss of a tooth that was already severely affected. Individuals with poor bone quality (degraded TBS) had, on average, one additional tooth with disease progression compared with those with normal bone quality. Among women after menopause, about two additional teeth were affected, and these women were nearly twice as likely to have more teeth with worsening gum disease. These findings suggest an association between decreased skeletal bone quality and a higher risk of gum disease. Early detection of weak bone quality, combined with proper oral care, may help to slow disease progression and to improve quality of life.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"212 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of leaving periodontal disease untreated on healthcare expenditures: A retrospective cohort study.","authors":"Anna Kinugawa,Kenji Takeuchi,Yudai Tamada,Taro Kusama,Futoshi Oda,Megumi Maeda,Hiroe Ohyama,Ken Osaka,Haruhisa Fukuda","doi":"10.1002/jper.70136","DOIUrl":"https://doi.org/10.1002/jper.70136","url":null,"abstract":"BACKGROUNDThis study aimed to investigate whether healthcare expenditures (HCEs) differed depending on whether the patients left periodontal disease (PD) untreated, despite the need for treatment.METHODSThis study used public PD screening data from a municipality in Japan to identify adults aged ≥ 40 years who were found to require treatment of PD by dentists at PD screening. The presence or absence of periodontal treatment was determined by a dental visit within 180 days after the date of PD screening based on medical claims data. Annual HCE were calculated from cumulative expenditures over 2 years from the date of the presence or absence of periodontal treatment. A generalized linear model with a gamma distribution and log link function was used to calculate the relative cost ratios (RCRs) and 95% confidence intervals (95% CI), and a two-part model was used to predict annual HCEs and the difference in predicted HCEs based on dental treatment.RESULTSAmong 652 people (mean age: 62.6 years [1 SD = 9.0], 65.5% women), 9.0% were untreated. After adjusting for the covariates, the RCR for medical, pharmaceutical, and dental costs in the untreated group compared with the treated group were 1.56 (95% CI: 1.02-2.38), 0.95 (95% CI: 0.53-1.70), and 0.14 (95% CI: 0.10-0.19), respectively. The differences in predicted HCEs were $593.5 (95% CI: -280.6, 1467.6) higher for medical, $79.9 (95% CI: -363.6, 523.4) higher for pharmaceutical, and $323.9 (95% CI: -397.3, -250.6) lower for dental.CONCLUSIONLeaving PD untreated was associated with increased HCEs, particularly medical expenditures.PLAIN LANGUAGE SUMMARYThis study looked at whether people who were told by a dentist that they needed care for periodontal disease actually received treatment, and how this affected their healthcare costs. The research followed more than 600 adults in Japan for 2 years, comparing the cumulative healthcare costs of those who received dental care with those who did not. The results showed that people who did not treat their periodontal disease ended up spending more on medical care, even though they spent less on dental care. On average, untreated individuals had medical expenses that were around $600 higher than those who received treatment. This suggests that avoiding dental care for periodontal disease might lead to more serious health problems down the line, which can increase overall healthcare costs. Although skipping dental visits may seem like a way to save money, it could actually lead to higher medical bills in the future. These findings highlight the importance of early dental treatment not just for oral health, but also for managing overall healthcare costs and preventing other health complications.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"23 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147708505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consuming heat-inactivated Lactiplantibacillus pentosus ONRICb0240-containing postbiotics reduces gingival inflammation: A double-blind randomized clinical trial.","authors":"Anhao Liu,Megumi Ishiguro,Yasuhiro Matsumura,Kyungtak Kwak,Seiichi Shimizu,Keiko Watabe,Hirotaka Nagashima,Shogo Maekawa,Takanori Iwata","doi":"10.1002/jper.70141","DOIUrl":"https://doi.org/10.1002/jper.70141","url":null,"abstract":"BACKGROUNDPeriodontal disease affects people globally, requiring approaches to halt progression at the gingivitis stage. Researchers have investigated live probiotics; we studied the effect of a heat-inactivated preparation (postbiotic) of Lactiplantibacillus pentosus ONRICb0240 on gingival inflammation.METHODSA total of 116 participants with gingival inflammation but no periodontitis were randomized into groups administered placebo or postbiotic gummies containing heat-inactivated L. pentosus ONRICb0240 (b0240GC) twice daily for 6 weeks. The participants maintained their usual oral hygiene practices without additional instruction or treatment. The bleeding on probing percentage (BOP), probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), plaque control record (PCR), and salivary volume were clinically assessed.RESULTSBOP was the primary endpoint, significantly decreased in the b0240GC group (baseline vs. 6 weeks; 17.6 ± 8.4% vs. 12.3 ± 8.6%, p &lt; 0.001) compared with that in the placebo group (18.9 ± 8.5% vs. 16.6 ± 10.1%, p = 0.344) in a sensitivity analysis excluding participants who used nonsteroidal anti-inflammatories. PPD, CAL, and PCR were the secondary endpoints that minimally changed, whereas the GI was significantly lower in the b0240GC group (baseline vs. 6 weeks: 1.3 ± 0.4 vs. 1.1 ± 0.6; p = 0.001) than in the placebo group (1.4 ± 0.4 vs. 1.3 ± 0.6). Exploratory post hoc subgroup analysis suggested stronger responses of BOP reduction in the b0240GC group among participants with a body mass index ≥22 kg/m2, a baseline BOP &lt; 20%, or a PCR &lt; 60%.CONCLUSIONSContinuously consuming b0240GC reduced gingival inflammation, excluding the influence of nonsteroidal anti-inflammatories, with no apparent safety concerns.TRIAL REGISTRATIONID number: jRCTs031220449; URL: https://jrct.mhlw.go.jp/en-latest-detail/jRCTs031220449 PLAIN LANGUAGE SUMMARY: Gum disease is also known as periodontal disease. Gum disease is common worldwide and can lead to tooth loss if not treated early. In the early gingivitis stages, the gums turn red and easily bleed. In addition to regular dental visits, simple methods must be developed for preventing the progression of gum disease, such as methods for safely reducing gum inflammation without disturbing the normal bacteria in the mouth. We tested whether eating gummy candies containing heat-inactivated bacteria (Lactiplantibacillus pentosus ONRICb0240) (b0240GC) improved gum health. We asked 116 adults with mild gum inflammation to eat either b0240GC or placebo gummies twice daily for 6 weeks. The participants did not receive any special instructions for brushing or cleaning their teeth during the study period; therefore, the results reflected real-life conditions. We found that less gum bleeding was experienced by people in the b0240GC group than those in the placebo group at the end of the study, and their gums appeared healthier overall. These findings suggest that b0240GC is helpful for safe","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"129 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of periodontal treatment on adipokines in patients with type 2 diabetes mellitus: A systematic review.","authors":"Natalia Christaki,Dimitra Baladina,Panagiotis A Koromantzos,Yiorgos A Bobetsis","doi":"10.1002/jper.70121","DOIUrl":"https://doi.org/10.1002/jper.70121","url":null,"abstract":"BACKGROUNDPeriodontal disease (PD) is associated with type 2 diabetes mellitus (T2DM), while periodontal treatment (PT) improves glycemic control in T2DM patients. Leptin and adiponectin belong to the adipokines family and have almost antagonistic functions in inflammatory processes and insulin sensitivity modulation. Hence, these hormones have been linked with both PD severity and glycemic control. This systematic review aims to assess the effect of PT on serum levels of leptin and adiponectin in patients with T2DM.METHODSPubMed, Cochrane Library, and Google Scholar databases and ClinicalTrials.gov website were searched up to January 5th, 2025. Randomized and non-randomized controlled clinical trials (RCTs and CCTs) including patients with T2DM and PD who underwent PT and evaluated serum levels of leptin and adiponectin were included. Assessments of risk of bias and of certainty of evidence were performed.RESULTSSeven trials were eligible for qualitative synthesis. A statistically significant increase in serum adiponectin levels was observed across most studies, while no such consistency was observed for leptin. The overall level of certainty of evidence was judged low in the RCTs and very low in the CCTs. Meta-analysis could not be performed due to significant methodological heterogeneity.CONCLUSIONSPreliminary findings suggest a potential increase in adiponectin levels in T2DM patients, with possible implications for glycemic control. However, these results should be interpreted with caution due to the small number of studies and important methodological limitations. Well-designed studies with larger sample sizes and adequate adjustment for confounders are necessary to verify this observation.PLAIN LANGUAGE SUMMARYPeople with type 2 diabetes often also have periodontitis, an inflammatory gum disease, which may affect their overall health. The aim of this study was to investigate whether treating periodontitis could help improve certain substances in the blood-called adiponectin and leptin-that are linked to blood sugar control and inflammation. Several studies that tested this in people with both diabetes and periodontitis were included and most of them showed that, after periodontal treatment, levels of adiponectin (which helps reduce inflammation and improve insulin sensitivity) increased. However, results for leptin were less clear. This suggests that taking care of gum health might support better diabetes management. The overall strength of evidence was low due to methodological limitations and heterogeneity among studies. Current findings should be interpreted cautiously, as available data remain preliminary. Still, more high-quality research is needed to fully understand how treating periodontitis may benefit people with diabetes.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"53 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147708483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between periodontitis and oral health-related quality of life in patients with systemic conditions: A meta-analysis.","authors":"Rafael Vargas Bortolaso,Catiusse Crestani Del' Agnese,Leandro Machado Oliveira,Patricia A Miguez,Fabricio Batistin Zanatta,Raquel Pippi Antoniazzi","doi":"10.1002/jper.70130","DOIUrl":"https://doi.org/10.1002/jper.70130","url":null,"abstract":"BACKGROUNDThe objective of this systematic review is to evaluate whether periodontitis is associated with impaired oral health-related quality of life (OHRQoL) in adults with systemic conditions.METHODSFive databases were searched to identify observational studies that tested the association between periodontitis (diagnosed by clinical periodontal examination) and OHRQoL (validated instrument). Random-effects models were applied in the meta-analyses, and the Newcastle-Ottawa Scale (NOS) was used for quality assessment.RESULTSSeventeen studies were included, with 94.1% using the OHIP-14 instrument. Only one study was rated as high quality. Meta-analysis showed a small and significant association between periodontitis and impaired OHRQoL (SMD: 0.31; 95% CI: 0.03-0.59). Individuals with periodontitis had higher OHIP-14 scores than the comparison group (MD: 2.29; 95% CI: 0.24-4.33). Studies using the 2017 periodontitis classification yielded significantly higher estimates than those using earlier criteria. Furthermore, a strong negative impact of periodontitis on OHRQoL was observed among individuals with psoriasis, whereas no significant association was identified for other systemic conditions.CONCLUSIONSPeriodontitis has a small negative impact on OHRQoL in patients with comorbidities. The type of systemic condition and the periodontitis diagnostic criteria influence this association.PLAIN LANGUAGE SUMMARYPeriodontitis negatively impacts oral health-related quality of life across different populations. However, this impact may appear smaller in individuals with certain systemic conditions, as additional health challenges can overshadow the perceived effects of periodontitis on daily life. Our systematic review found a small negative impairment of OHRQoL associated with periodontitis in patients with comorbidities, with the magnitude of this association influenced by the type of systemic condition and the diagnostic criteria used to define periodontitis. Further high-quality studies are needed to strengthen the current evidence.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"29 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147708516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}