Journal of periodontology最新文献

{"title":"Association between periodontitis and exudative retinal detachment: A population-based cohort study.","authors":"Earl Fu, Ming-Ling Tsai, Tsu-Hsuan Weng, Chi-Hsiang Chung, Min-Wen Fu, Wu-Chien Chien","doi":"10.1002/jper.70197","DOIUrl":"https://doi.org/10.1002/jper.70197","url":null,"abstract":"<p><strong>Background: </strong>To investigate whether periodontitis, a common bacterial-induced inflammatory condition, serves as a risk factor for exudative retinal detachment (ERD), which results from fluid entering the subretinal space due to damage to the retinal pigment epithelium or leaky intraocular vessels, typically associated with inflammatory, infectious, or retinal diseases.</p><p><strong>Methods: </strong>Using Taiwan's National Health Insurance Research Database (2000-2020), patients with periodontitis were identified based on at least three outpatient visits within 1 year. A comparison cohort without periodontitis was selected and matched 1:1 using propensity scores for sex, age, index year, and Charlson Comorbidity Index. Each group included 167,530 individuals. The periodontitis cohort was further divided into treated and untreated subgroups according to periodontal treatment codes (n = 68,705 and 98,825, respectively).</p><p><strong>Results: </strong>During follow-up, ERD occurred in 0.26% (n = 437) of patients with periodontitis and 0.06% (n = 100) of those comparison individuals. Compared with the comparison group, the cumulative risk of ERD was significantly higher in the periodontitis group and in both two subgroups. The incidence rates of exudative retinal detachment were 16.74 and 3.55 per 10<sup>5</sup> person-years in the periodontitis and comparison groups, respectively. Patients with periodontitis were associated with a higher hazard of ERD (3.95, 3.42, and 3.56 for crude, adjusted, and adjusted subdistribution hazard ratios, respectively). Sensitivity analyses showed the increased hazard of ERD remained significant after time-lag exclusions and in two periodontitis subgroups.</p><p><strong>Conclusion: </strong>Based on the whole-population study in Taiwan, patients with periodontitis exhibit an increased incidence of ERD, suggesting a potential association between periodontitis and ERD.</p><p><strong>Plain language summary: </strong>Gum disease is a common infection that causes ongoing inflammation in the mouth, and growing evidence suggests it may affect more than just oral health. In this large study using national health data from Taiwan, we examined whether people with gum disease are more likely to develop exudative retinal detachment, a serious eye condition in which fluid builds up under the retina and can impair vision. By comparing 167,530 patients with gum disease with an equal number without it, matched for age, sex, and general health, we found that this eye condition occurred much more frequently among those with gum disease. Even after accounting for other medical conditions, individuals with periodontitis were more than three times as likely to experience this form of retinal detachment. This pattern was consistent regardless of whether patients had received specific gum treatments. These results suggest that chronic inflammation from gum disease may be connected to eye disorders, emphasizing that main","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AAP President's Address*","authors":"Maria L. Geisinger","doi":"10.1002/jper.70209","DOIUrl":"https://doi.org/10.1002/jper.70209","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"29 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond statistical significance: Interpreting effect sizes in dental research","authors":"Dimitris Sokos, Lotte P. M. Weijdijk, Dagmar Else Slot, G. A van der Weijden","doi":"10.1002/jper.70218","DOIUrl":"https://doi.org/10.1002/jper.70218","url":null,"abstract":"<jats:label/> Despite substantial advances in dental and periodontal research, study findings are still frequently interpreted primarily on the basis of statistical significance, potentially leading to overestimation of their clinical relevance. This issue is particularly relevant in studies, where small absolute numerical changes in outcomes such as clinical attachment level or probing pocket depth may reach statistical significance without translating into meaningful clinical benefits for patients. Greater emphasis should be placed on effect sizes, which provide critical information on the magnitude and direction of treatment effects or strengths of associations and correlations. In addition, confidence intervals play an important role for assessing study findings, as they convey the precision of estimates and help determine whether observed effects are likely to be clinically meaningful. A shift in focus from statistical significance alone to a more balanced evaluation that includes effect magnitude and precision is necessary to improve the translation of research into practice. Scientific authors, reviewers, and journal editorial teams share responsibility for promoting this broader framework for interpreting research findings. Prioritizing clinically meaningful interpretation over mere statistical significance will strengthen the relevance and impact of periodontal research and support more informed clinical decision‐making processes.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"10 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between xerostomia and peri‐implant health: A retrospective cohort study","authors":"Shahad Alhazmi, Sahar Baniameri, Parham Hazrati, Yousef Amrou, Fatemeh SamavatiJame, Hom‐Lay Wang, Muhammad H. A. Saleh","doi":"10.1002/jper.70192","DOIUrl":"https://doi.org/10.1002/jper.70192","url":null,"abstract":"Background Dental implants are a long‐term and reliable solution to replace missing dentition, but subject to different patient‐related and biological changes that could alter its success. Xerostomia, or the alteration of the normal salivary flow, can impair oral function and potentially affect the success of any treatment, including implant outcomes. The purpose of this study is to study the association between xerostomia and peri‐implantitis. Methods A retrospective cohort study was conducted using records of patients who received dental implants between 2010 and 2023 at the University of Michigan School of Dentistry. The patients were divided into two groups: the xerostomia group and the non‐xerostomia group. Implant level assessment included the presence of peri‐implantitis and marginal bone loss, restoration type, cement‐retained or screw retained, and the depth of restoration margin. Patient‐level assessment included sex, age, smoking history, medical conditions, and maintenance visit frequency. Univariable and multivariable mixed‐effects logistic regression analyses were performed to assess the association between peri‐implantitis and patient‐level and other implant‐related variables. Odds ratios with 95% confidence intervals were reported, and statistical significance was defined as <jats:italic>p &lt;</jats:italic> 0.05. Results A total of 173 patients were included, with 46 patients reporting xerostomia. The results showed no independent association between xerostomia and peri‐implantitis in either univariable or multivariable analyzes. The history of periodontitis and cement‐retained restorations were significant predictors for peri‐implantitis. Age was significant in univariable analysis but lost significance in the adjusted model. The frequency of maintenance visits was associated with peri‐implantitis in univariable analysis but lost significance in multivariable analysis. Sex, smoking, and diabetes mellitus were not significantly associated with peri‐implantitis. Conclusion Xerostomia alone does not increase the risk of peri‐implantitis. A history of periodontitis, the use of cement‐retained prosthesis, and longer follow‐up duration after prosthetic loading were associated with unfavorable implant outcomes.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"13 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METTL3-mediated m6A methylation of lipopolysaccharide-binding protein exacerbates periodontitis by promoting M1 macrophage polarization.","authors":"Hongwei Wang, Huina Li, Chuang Li, Jiandong Ban, Hua Xu, Xiaotong Qiao","doi":"10.1002/jper.70195","DOIUrl":"https://doi.org/10.1002/jper.70195","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Periodontitis is a chronic inflammatory disease driven by dysregulated immune responses and is closely associated with macrophage polarization. N6-methyladenosine (m6A) methylation represents the most prevalent RNA modification; however, its role in periodontitis remains unclear. This study aimed to investigate the mechanism by which m6A modification regulates macrophage polarization during the progression of periodontitis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A periodontitis mouse model was established by ligature induction. RAW264.7 macrophages were treated with Porphyromonas gingivalis-derived lipopolysaccharide (LPS) to simulate inflammatory conditions in vitro. Micro-computed tomography (micro-CT), hematoxylin-eosin and immunohistochemical staining, quantitative real-time polymerase chain reaction (qPCR), immunofluorescence staining, methylated RNA immunoprecipitation (MeRIP), and luciferase reporter assays were used to evaluate alveolar bone loss, macrophage phenotypes, and m6A-dependent regulatory mechanisms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Methyltransferase-like 3 (METTL3) expression was significantly upregulated in periodontitis tissues and in LPS-stimulated macrophages. Knockdown of METTL3 attenuated alveolar bone resorption, reduced pro‑inflammatory M1 markers (tumor necrosis factor-alpha [TNF-α], interleukin-6 [IL-6]), and increased M2 markers (IL-10, arginase-1 [Arg-1]) in mice. In LPS-treated RAW264.7 cells, METTL3 knockdown suppressed M1 polarization markers (CD86, TNF-α, IL-1β) and enhanced M2 markers (CD206, transforming growth factor-beta [TGF-β]). Mechanistically, METTL3 stabilized LPS-binding protein (LBP) mRNA via m6A modification, and overexpression of LBP reversed the METTL3 knockdown-mediated suppression of M1 polarization. RNA immunoprecipitation (RIP) and dual-luciferase assays identified YTHDF1 as the m6A reader responsible for recognizing LBP mRNA. These results indicate that METTL3 promotes periodontitis by enhancing LBP mRNA stability through m6A methylation, thereby driving M1 macrophage polarization.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study identifies the METTL3-LBP-YTHDF1 axis as a key regulator of macrophage-driven inflammation in periodontitis, providing new potential therapeutic targets for modulating immune responses in periodontal disease.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;Periodontitis is a common chronic inflammatory disease that damages gum tissue and tooth-supporting bones and can lead to tooth loss if untreated. Immune cells called macrophages play a key role here-when they become \"pro-inflammatory\" (promoting inflammation), the disease worsens. We studied a molecule called methyltransferase-like 3 (METTL3), which is more abundant in periodontitis tissues and inflamed cells. Using mouse models and lab-grown cells, we found that reducing METTL3 levels eased inflammation, protected tooth-supporting bones, and shifted macrophages from pro-inflammatory to anti-in","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent pregnancy and self-reported gingival bleeding: Evidence from a national sample.","authors":"Elizabeth T Couch, Benjamin W Chaffee","doi":"10.1002/jper.70187","DOIUrl":"https://doi.org/10.1002/jper.70187","url":null,"abstract":"<p><strong>Background: </strong>Gingivitis is associated with pregnancy, yet this relationship has not been quantified in large, community-dwelling samples. Such samples offer the opportunity to examine the utility of self-reported oral health measures by examining associations with known risk factors. This study aimed to evaluate the associations of pregnancy status with self-reported gum bleeding in a nationally representative (United States) cohort.</p><p><strong>Methods: </strong>A total of 14,107 female participants aged 18-44 in the Population Assessment of Tobacco and Health (PATH) Study waves 4-7 (collected 2016-2023) contributed 36,201 total observations, including 1348 observations when currently pregnant and 3025 when pregnant within the past 12-months (not currently). Survey-weighted, multivariable logistic regression models estimated cross-sectional associations between pregnancy and self-reported past 12-month gum bleeding. Also, multivariable conditional logistic regression models estimated within-person associations between pregnancy and gum bleeding for participants observed both when pregnant and not pregnant.</p><p><strong>Results: </strong>Gum bleeding prevalence was 35.9% when participants had been pregnant in the past 12 months (currently or not) and 31.1% otherwise. Adjusted for all covariables, odds of gum bleeding when currently pregnant were 1.64 (95% confidence interval [CI]: 1.35, 1.99) times those when not pregnant in the past 12 months. Among women observed both when pregnant and when not pregnant, adjusted odds of gum bleeding when pregnant within the past 12 months were 1.45 (95% CI: 1.29, 1.64) times those when not pregnant.</p><p><strong>Conclusions: </strong>The results also support the construct validity of self-reported gum bleeding for epidemiologic studies, which may complement clinical measures while being more feasible to collect in population surveillance.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crestal bone changes in tissue-level implants according to implant placement depth: A retrospective cohort study.","authors":"Stephanie Dye, Nathalia Vilela, Sarah E McPherson, Rafael Lazarin, Xinlin Lu, Guogen Shan, Karin C Schey, Poliana M Duarte","doi":"10.1002/jper.70214","DOIUrl":"https://doi.org/10.1002/jper.70214","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the effect of tissue-level implant placement depth on crestal bone changes before and after loading and explored patient-, implant-, and prosthesis-related factors associated with these changes.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with at least one tissue-level implant. Implants were classified by placement depth (crestal, partially, or completely subcrestal). Crestal bone levels were assessed radiographically at placement, pre-loading, and post-loading, and categorized relative to the smooth collar or implant body. Clinical records provided patient, implant, and prosthesis data. Associations were analyzed using mixed-effects logistic regression model.</p><p><strong>Results: </strong>A total of 183 implants (20 crestal, 100 partially subcrestal, and 63 completely subcrestal) were analyzed in 96 patients. Crestal implants showed no pre-loading crestal bone change and remained stable post-loading. In subcrestal implants, bone change was mainly confined to the smooth collar. Completely subcrestal implants showed higher odds of exhibiting a more apically located pre-loading crestal bone change (adjusted odds ratio [OR] = 2.44, p = 0.045) than partially subcrestal implants. Among implants without pre-loading bone change, completely subcrestal placement was associated with a higher probability of post-loading bone change compared with partially subcrestal placement (91.8% vs. 49.2%; adjusted OR = 11.56, p = 0.035). No other variables were significantly associated with these outcomes (p > 0.05).</p><p><strong>Conclusions: </strong>Placement depth was a key factor associated with crestal bone changes in tissue-level implants. Subcrestal placement was associated with greater pre-loading crestal bone change in a depth-dependent manner, with the highest risk of post-loading change observed in completely subcrestal implants without prior bone remodeling. Both pre- and post-loading changes were predominantly confined to the smooth collar.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mertk drives alveolar bone loss in experimental periodontitis associated with altered neutrophil function and osteoclast recruitment.","authors":"Nicholas Mazzara, Kesley Martin, Rana Dabaja, Justin Redmond, Victoria Maglaras, Maxwell Mianecki, Harout Ashekian, Joseph T Decker, Ann M Decker","doi":"10.1002/jper.70202","DOIUrl":"https://doi.org/10.1002/jper.70202","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Alveolar bone loss is the hallmark of periodontitis and often remains refractory to conventional mechanical and antimicrobial therapies in chronic cases. Mer receptor tyrosine kinase (Mertk) has been implicated in bone homeostasis, yet the immune mechanisms by which Mertk modulates periodontal bone resorption remain insufficiently characterized. The aim of this study is to investigate the role of Mertk deficiency in modulating the inflammatory response during ligature-induced periodontitis and its impact on alveolar bone loss.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;C57BL/6J wild-type (WT) and Mertk&lt;sup&gt;-∖-&lt;/sup&gt; mice at 6- to 8-weeks-old were assigned to two experimental groups, the healthy control and ligated. Eight WT and eight Mertk&lt;sup&gt;-∖-&lt;/sup&gt; mice received a 5-0 braided silk ligature around the left second maxillary molar for 7 days to induce experimental periodontitis. The remaining mice were used as healthy controls. Alveolar bone loss was measured morphometrically, and each condition used five mice. Immune cell populations were characterized by flow cytometry. Neutrophil reactive oxygen species (ROS) production was assessed by in vivo luminol imaging, and degranulation was evaluated ex vivo following PMA stimulation. The presence of osteoclasts in sulcular tissues was quantified using TRAP staining. A minimum of three mice (n ≥ 3) were used in all experiments. The results were compared using two-way ANOVA followed by Tukey's multiple comparison correction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;At a healthy baseline, Mertk&lt;sup&gt;-∖-&lt;/sup&gt; mice showed significantly shorter alveolar bone crest to CEJ distances than WT controls (0.174 ± 0.005 mm WT, 0.146 ± 0.012 mm Mertk&lt;sup&gt;-∖-&lt;/sup&gt;, p &lt; 0.001). When presented with ligature-induced periodontitis, Mertk&lt;sup&gt;-∖-&lt;/sup&gt; mice demonstrated significantly reduced alveolar bone loss compared with WT controls (0.065 ± 0.019 mm vs. 0.122 ± 0.005 mm; p &lt; 0.001). Neutrophil proportions increased in both groups following ligation (p &lt; 0.0001), though Mertk&lt;sup&gt;-∖-&lt;/sup&gt; mice had higher baseline neutrophil levels (p &lt; 0.05) and elevated baseline B-cell proportions (p &lt; 0.0001). Under ligated conditions, Mertk&lt;sup&gt;-∖-&lt;/sup&gt; neutrophils produced significantly less ROS (p &lt; 0.05), and PMA-induced degranulation was reduced in Mertk&lt;sup&gt;-∖-&lt;/sup&gt; neutrophils from healthy mice (p &lt; 0.001). TRAP staining revealed 28% fewer osteoclasts in Mertk&lt;sup&gt;-∖-&lt;/sup&gt; sulcular tissues versus WT following ligation (89 ± 7 vs. 123 ± 9 per section; p &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Genetic ablation of Mertk attenuates alveolar bone resorption in experimental periodontitis by modulating neutrophil function and reducing osteoclast recruitment. This research identifies Mertk as a potential target for preserving alveolar bone in periodontal disease and supports further preclinical evaluation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;Periodontitis causes inflammation that destroys the bone su","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New periodontal phenotype classification in patients with different types of malocclusion and dental crowding","authors":"Abeer A. Al‐Sosowa, Ehab A. Abdulghani, Wang Meng, Jiajun Zhu, Pei‐Hui Ding","doi":"10.1002/jper.70196","DOIUrl":"https://doi.org/10.1002/jper.70196","url":null,"abstract":"Background The periodontal phenotype plays a critical role in periodontal stability and orthodontic risk assessment. However, an integrated evaluation of soft‐ and hard‐tissue periodontal characteristics across various sagittal and vertical skeletal patterns and dental crowding remains limited. This study applied an innovative cluster‐based classification of periodontal phenotype to evaluate these variances. Methods This cross‐sectional study included 180 participants and 1080 maxillary anterior teeth. Using superimposed cone beam computed tomography and intraoral scan data, the thickness of the gingiva (GT) and the thickness of the alveolar bone (ABT) was evaluated. The keratinized tissue width (KTW) was obtained from intraoral images utilizing a correction factor. Subjects were classified by sagittal skeletal classification, vertical skeletal patterns, and crowding severity. Periodontal phenotype clusters were assigned using a previously developed classification framework. Statistical analyses included chi‐square tests with Monte Carlo simulation for categorical comparisons and multinomial logistic regression to assess associations between cluster membership and potential covariates. Results The distribution of periodontal phenotype clusters was significantly associated with the sagittal skeletal classification and vertical skeletal patterns, with Class III and hypodivergent groups being more commonly found in thin or majority‐thin clusters. While the dental crowding severity showed no significant correlation with periodontal phenotype. Conclusions The anterior periodontal phenotype is not randomly distributed but rather reflects sagittal and vertical skeletal patterns and is independent of tooth alignment and crowding severity. Class III and hypodivergent patterns are more commonly associated not only with reduced GT but also with narrow KTW and reduced ABT, which highlights the importance of phenotype‐guided risk assessment in orthodontic planning.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"54 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New technologies in oral reconstructive medicine: Consensus report of the AAP/OF/SEPA Workshop","authors":"Mariano Sanz,&nbsp;Sašo Ivanovski,&nbsp;José Nart,&nbsp;Frank Schwarz,&nbsp;Hom-Lay Wang,&nbsp;Tara L. Aghaloo,&nbsp;Bilal Al-Nawas,&nbsp;Gustavo Avila-Ortiz,&nbsp;Shayan Barootchi,&nbsp;Juan Blanco,&nbsp;Gonzalo Blasi,&nbsp;Nikolaos Donos,&nbsp;Balazs Feher,&nbsp;Irina F. Dragan,&nbsp;Maria L. Geisinger,&nbsp;Adrián Guerrero,&nbsp;Effie Ioannidou,&nbsp;Darnell Kaigler,&nbsp;Yvonne Hernandez-Kapila,&nbsp;Purnima S. Kumar,&nbsp;Liran Levin,&nbsp;Antonio Liñares,&nbsp;George A. Mandelaris,&nbsp;Paula Matesanz-Pérez,&nbsp;Alberto Monje,&nbsp;Eduardo Montero,&nbsp;Alberto Ortiz-Vigón,&nbsp;Joan Otomo-Corgel,&nbsp;Flavia Q. Pirih,&nbsp;Ausra Ramanauskaite,&nbsp;Isabella Rocchietta,&nbsp;Vanessa Ruiz-Magaz,&nbsp;Hanae Saito,&nbsp;Nerea Sánchez,&nbsp;Javier Sanz Esporrin,&nbsp;Anton Sculean,&nbsp;Florian M. Thieringer,&nbsp;Daniel S. Thoma,&nbsp;Cristina Valles,&nbsp;Diego Velásquez,&nbsp;David T. Wu,&nbsp;William V. Giannobile","doi":"10.1002/jper.70182","DOIUrl":"https://doi.org/10.1002/jper.70182","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The objectives of this Workshop were to evaluate the efficacy of scaffolding technologies for horizontal and vertical ridge augmentation; to evaluate the efficacy of substitute scaffolds for soft tissue augmentation in the context of implant therapy; to evaluate the efficacy of cells and/or biologics combined with scaffolds for alveolar bone regeneration; to evaluate the efficacy of cells and/or biologics combined with scaffolds for soft tissue regeneration in the context of implant therapy; and to evaluate emerging technologies and personalized strategies for improving hard and/or soft tissue defects around natural teeth and dental implants.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The Workshop discussions were informed by five specifically commissioned systematic reviews from the following three Working Groups: Working Group 1 – Use of scaffolds for bone and soft tissue regeneration; Working Group 2 – Use of cells and/or biologics combined with scaffolds for hard and soft tissue regeneration; and Working Group 3 – Current, emerging, and personalized approaches for periodontal and peri-implant tissue regeneration. The Workshop participants were informed by the compiled evidence from the five systematic reviews within each Working Group to address pertinent issues to inform clinical practice, research, and the public community.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The consensus among the Workshop group participants was that cellular therapies and biologics, alone and in combination with scaffolding technologies, offer strong potential in regenerating tissues around teeth and dental implants. There was variability in treatment outcomes depending on the overall evidence and the efficacy of these technologies, as well as on the specific defects and patient-based constraints. The consensus report detailed the results and implications of the findings, demonstrating the value of these technologies in improving clinical and patient-reported outcomes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Current regenerative approaches lead to long-term stable outcomes at natural teeth as well as dental implant sites; novel technologies can benefit patients by enhancing longer-term stability of teeth and implants to promote the health of the oral cavity and dentition; and artificial intelligence–enabled modeling can contribute to the identification of relevant features at the individual (as opposed to population) level, empowering patients to be active participants in their journeys and improving science-to","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 S1","pages":"S8-S32"},"PeriodicalIF":4.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}