Journal of periodontology最新文献

{"title":"The effect of leukocyte-platelet-rich fibrin in periodontal surgery on clinical parameters and patient-related outcome measures: A randomized, controlled, clinical study.","authors":"Jackson S Sides,Archontia Palaiologou,Brian L Mealey,Stephan J Haney,Kerri Font,Charles A Powell","doi":"10.1002/jper.70166","DOIUrl":"https://doi.org/10.1002/jper.70166","url":null,"abstract":"BACKGROUNDThis prospective study aimed to assess the clinical outcomes and patient-related outcome measures (PROMs) of open flap debridement (OFD) alone versus open flap debridement with leukocyte-platelet-rich fibrin (L-PRF).METHODSTwenty-one patients were enrolled into a split-mouth randomized clinical trial. One side of the arch underwent OFD; the contralateral side of the same arch underwent the same OFD procedure with L-PRF placed across the alveolar bone and root surfaces underneath the buccal and lingual/palatal flap. Clinical parameters for probing depth (PD) and relative gingival recession (RGR) were recorded at six sites per tooth using a thermoplastic stent at baseline (immediately before surgery), 3 months, and 6 months. Bleeding on probing (BOP) and plaque scores were recorded at six sites per tooth throughout the study duration.RESULTSThe greatest reductions in PD were observed for sites ≥ 7 mm. Mean PD in the control group decreased from 7.38 mm at baseline to 3.15 mm at 3 months, with a subsequent increase to 4.00 mm at 6 months. In contrast, the test group demonstrated a sustained reduction from 7.75 mm at baseline to 3.25 mm at 3 months and 3.19 mm at 6 months. In moderate sites (4-6 mm), both groups demonstrated substantial PD reduction. Moderate subgroup mean PD decreased from 4.62 mm to 3.09 mm in the control group and from 4.76 mm to 3.19 mm in the test group at the 6-month timepoint. Relative recession and relative attachment level revealed no significant differences between the groups across all PDs. PROMs data showed that, although test group patients reported more swelling and pain early after surgery, they used less analgesics than the control group.CONCLUSIONSBased on the findings from this randomized clinical study, L-PRF was found to have improved, sustained PD reduction in deep periodontal pockets compared to OFD alone. L-PRF was not found to have a significant impact on PROMs or soft tissue healing compared to OFD alone.CLINICALTRIALSGOV IDENTIFIERNCT06296498 PLAIN LANGUAGE SUMMARY: In this split mouth, same arch clinical study, 21 patients were randomized into two study groups: open flap debridement (OFD) and OFD plus leukocyte-platelet-rich fibrin (L-PRF). Clinical parameters were recorded at baseline, 3 months, and 6 months after intervention, while healing and patient-reported outcome measures (PROMs) were evaluated 2 and 4 weeks after surgery. In sites ≥ 7 mm baseline PD, OFD plus L-PRF was associated with greater probing depth (PD) reduction and attachment level (AL) gain than control OFD alone, with similar gingival recession in both groups. Overall test group PD decrease was 4.44 mm, resulting in 1.05 mm more PD decrease in test sites than control. L-PRF effect was sustained with PD values in test sites reduced to 3.25 mm and 3.19 mm at 3 and 6 months, respectively (from 7.75 mm at baseline). The addition of L-PRF did not provide benefits in PROMs and soft tissue healing compared to sites treated with OFD a","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"39 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148428865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective factors and critical mucosal thickness for the stability of the peri-implant soft tissue margin over 5 years: A longitudinal cohort study.","authors":"Lorenzo Tavelli,Hamoun Sabri,Erfan Barootchi,Martina Stefanini,Giovanni Zucchelli,Hom-Lay Wang,Istvan A Urban,Shayan Barootchi","doi":"10.1002/jper.70159","DOIUrl":"https://doi.org/10.1002/jper.70159","url":null,"abstract":"BACKGROUNDPeri-implant soft tissue dehiscence deficiencies (PSTDs) are common esthetic complications in the anterior maxilla, yet the parameters that protect the peri-implant soft tissue margin (STM) over time remain unclear. Previous studies have identified several risk indicators, but longitudinal thresholds capable of predicting stable STM have not been established. This study aimed to evaluate 5-year STM behavior and identify clinically meaningful predictors of long-term stability.METHODSThis prospective longitudinal study included patients with anterior single implants with or without PSTD. Clinical and ultrasonographic examinations were performed at baseline (T0) and 5 years (T5), and included STM stability (primary outcome), PSTD incidence, mucosal thickness at 1 and 3 mm from the STM (MT1 and MT3), keratinized mucosa (KM) width, buccal bone thickness (BBT), and buccal bone dehiscence (BBD). Logistic regression, receiver operating characteristic curve (ROC) analysis, stratified subgroup analysis, and correlation testing were performed.RESULTSA total of 133 implants in 124 patients were evaluated. PSTD prevalence increased from 51.1% at T0 to 74.4% at T5, (incidence 47.7%). MT3 was the dominant predictor of STM stability (AUC = 0.998). The optimal statistical threshold was 2.01 mm, while a clinical stability threshold of 2.23 mm yielded 100% stability in this dataset. Other predictors (MT1, KM, BBT) were significant only in univariate models. In implants without PSTD at T0, MT3 alone predicted stability, whereas in implants with PSTD at T0, multiple variables influenced STM outcomes.CONCLUSIONSMT3 is the critical determinant of 5-year STM stability at anterior implants. In our cohort, achieving a MT3 ≥ 2.23 mm was found to be associated with a long-term stable peri-implant soft tissue.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148428743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear association between tooth loss and cardiovascular diseases among middle-aged adults.","authors":"Taro Kusama,Yudai Tamada,Takashi Miyano,Megumi Maeda,Futoshi Oda,Ken Osaka,Haruhisa Fukuda,Kenji Takeuchi","doi":"10.1002/jper.70167","DOIUrl":"https://doi.org/10.1002/jper.70167","url":null,"abstract":"BACKGROUNDAlthough positive associations between fewer remaining teeth and an increased risk of various systemic diseases have been reported, the precise dose-response relationship has not been fully clarified. This study aimed to evaluate the non-linearity of the dose-response association between the number of lost teeth and the risk of cardiovascular diseases among middle-aged adults.METHODSThis retrospective cohort study, with over 5 years of follow-up, was based on medical claims and health check-up data. Participants were adults aged 40-64 in Japan. The outcome was the incidence of cardiovascular diseases. Exposure variables were the number of lost teeth, which was modeled using a restricted cubic spline. A Cox proportional hazards model was fitted to estimate hazard ratios (HRs) and 95% confidence intervals.RESULTSAmong the 551,386 participants (mean age = 50.0 years [SD = 6.7], male = 52.0%), the incidence rate of cardiovascular diseases was 0.70 per 100 person-years. A significant non-linear dose-response association was observed between the number of lost teeth and cardiovascular disease risk (p = 0.004). Although the risk increased with greater tooth loss, the dose-response curve bent at around four lost teeth, with an HR of 1.09 (1.05-1.14) at four teeth lost and 1.21 (1.08-1.37) at 27 teeth lost (reference: \"no tooth loss\").CONCLUSIONSThese findings suggest no clear threshold exists in the non-linear dose-response association between tooth loss and cardiovascular disease risk. Comprehensive public health strategies to prevent periodontal diseases and dental caries are essential throughout life to minimize tooth loss and its systemic consequences.PLAIN LANGUAGE SUMMARYThis retrospective cohort study of 551,386 middle-aged adults found a significant non-linear dose-response association between tooth loss and the risk of cardiovascular diseases. Cardiovascular disease risk increased as the number of lost teeth increased; however, the dose-response curve showed an inflection at around four lost teeth, with no clear threshold observed in the association between tooth loss and cardiovascular disease risk.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"29 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148428742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft: A randomized controlled trial","authors":"Anahat Khehra, Joseph Montesano, Lorenzo Tavelli, Chia-Yu Chen, David M. Kim","doi":"10.1002/jper.70036","DOIUrl":"10.1002/jper.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Conventional bone augmentation for dental implants typically involves particulate grafting materials, with the addition of barrier membranes, to preserve ridge dimensions. This study compares the changes in horizontal ridge width in patients undergoing alveolar ridge preservation (ARP) with a collagenated bovine bone xenograft (BG), with and without a non-crosslinked collagen membrane (MEM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A 6-month randomized clinical trial was conducted with 20 participants requiring ARP after tooth extraction. Participants were randomly assigned to two groups: Group 1, which received BG alone, and Group 2, which received BG + MEM. Both groups were allowed to heal by secondary intention. The outcomes of interest included clinical, radiographic, and ultrasonographic changes in hard and soft tissues and histologic and histomorphometric evidence of new bone formation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All enrolled participants completed the study, with a mean age of 54.25 ± 17.08 years, including 17 premolars, 1 canine, and 2 incisors. The baseline buccal bone thickness was similar between the groups (group 1: 1.02 ± 0.44 mm; group 2: 0.93 ± 0.45 mm; <i>p</i> = 0.662). At 6 months, no significant differences were observed between the groups for keratinized tissue width (group 1: 4.80 ± 1.48 mm; group 2: 4.80 ± 1.14 mm; <i>p</i> = 0.999), gingival thickness (group 1: 1.22 ± 0.25 mm; group 2: 1.20 ± 0.35 mm; <i>p</i> = 0.650), horizontal bone width at 3 mm from the crest (group 1: 9.02 ± 2.09 mm; group 2: 8.41 ± 1.45 mm; <i>p</i> = 0.464), and change in vertical bone at the buccal aspect (group 1: ∆ −0.78 ± 0.59 mm; group 2: ∆ −1.31 ± 1.20 mm; <i>p</i> = 0.244). Ultrasound evaluations were consistent with clinical measurements. Histologic analysis showed similar new bone formation between groups (group 1: 25.80% ± 15.48%; group 2: 27.89% ± 18.21%; <i>p</i> = 0.803).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The collagenated bone graft alone yielded comparable outcomes to its combination with a collagen membrane in areas with thick buccal bone, simplifying the treatment process by reducing costs, time, and the need for additional materials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov; Registration Number NCT05838651.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>This study compared two methods for socket preservation after tooth extraction: ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 6","pages":"1157-1169"},"PeriodicalIF":4.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 receptor agonists: Bridging diabetes, obesity, and periodontitis—A scoping review of emerging evidence","authors":"Angeliki Polymeri, Magda Feres, William V. Giannobile, Bruno G. Loos","doi":"10.1002/jper.70092","DOIUrl":"10.1002/jper.70092","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are analogs of the endogenous incretin hormone GLP-1 and are increasingly used in the treatment of diabetes and obesity. Beyond glycemic control and weight loss, they have demonstrated anti-inflammatory, antioxidative, and immunomodulatory properties. Given the inflammatory nature of periodontitis and its bidirectional relationship with diabetes mellitus, interest is growing in exploring the potential therapeutic benefits of GLP-1 RAs in periodontal diseases. This scoping review aims to search the existing literature on the effects of GLP-1 RAs on periodontitis, focusing on underlying mechanisms and emerging clinical implications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following PRISMA guidelines for scoping reviews, a comprehensive search was conducted in Medline/PubMed and Embase to identify preclinical and clinical studies in English evaluating the effects of GLP-1 RAs on periodontal tissues. Data were synthesized thematically to highlight key findings and gaps.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Evidence from mechanistic and preclinical studies supports a biologically plausible link between GLP-1 RAs and pathways central to periodontal inflammation and host response. Human studies remain limited and observational but consistently report associations between periodontitis and altered incretin hormone profiles, including reduced endogenous GLP-1 levels and increases following periodontal treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This scoping review identifies growing mechanistic and preclinical evidence suggesting potential interactions between GLP-1 RAs and periodontal inflammatory pathways. Although current human evidence is indirect and insufficient to establish therapeutic benefit, these early signals highlight an important opportunity for future research. Well-designed clinical trials with periodontal endpoints are needed to clarify whether GLP-1 RAs may provide adjunctive value in periodontal care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>GLP-1 receptor agonists are medications commonly used to manage diabetes and obesity. In addition to their metabolic effects, laboratory and animal studies suggest that these drugs may influence biological processes also involved in gum disease, such as inflammation, immune response, and bone metabolism. This scoping review examined all available scientific studies on the relationship between GLP-1 receptor agonists and periodontal disease. Most of the existing ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 6","pages":"1243-1256"},"PeriodicalIF":4.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum α-Klotho levels and severity of periodontitis in a representative U.S. population","authors":"Hamoun Sabri,&nbsp;Sahar Baniameri,&nbsp;Pranav Kataria,&nbsp;Hend Abulatifa,&nbsp;Parham Hazrati,&nbsp;Hom-Lay Wang,&nbsp;Muhammad H. A. Saleh","doi":"10.1002/jper.70080","DOIUrl":"10.1002/jper.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Periodontitis, a chronic inflammatory disease, is linked to systemic conditions such as cardiovascular and kidney disease. Serum α-Klotho, an anti-aging protein with anti-inflammatory properties, has been associated with systemic diseases, but its role in periodontitis is unclear. This study evaluated the relationship between serum α-Klotho levels and periodontitis severity while accounting for confounders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this cross-sectional study, data from 961 participants in the National Health and Nutrition Examination Survey (NHANES) database were analyzed. Periodontitis was classified into stages (I–IV) and grades (A–C) using the ACES (Application of the 2018 periodontal status Classification to Epidemiological Survey data) guidelines. Serum α-Klotho levels were measured via enzyme-linked immunosorbent assay (ELISA). Ordinal logistic regression assessed associations between α-Klotho levels and periodontitis, adjusting for confounders such as age, smoking, comorbidities, and oral hygiene. The number of lost teeth was analyzed as a secondary outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In both adjusted and unadjusted regression models, no significant association was found between α-Klotho levels and periodontitis. Particularly, adjusted models revealed no significant association between α-Klotho levels and periodontitis stage (OR = 1.0001, <i>p</i> = 0.547, 95% CI: 0.9997–1.0006) or grade (OR = 0.9996, <i>p</i> = 0.144, 95% CI: 0.9991–1.0001). Age, smoking, and comorbidities significantly predicted severity. Despite a weak negative correlation between α-Klotho and tooth loss (<i>r</i> = –0.07, <i>p</i> = 0.023), this association was no longer significant after adjustment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>No significant association was found between serum α-Klotho levels and periodontitis severity. Age, smoking, and comorbidities were key predictors, highlighting the multifactorial nature of periodontitis. Further longitudinal and mechanistic studies are needed to clarify whether α-Klotho has a value as a biomarker of periodontal inflammation or disease progression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 6","pages":"1340-1350"},"PeriodicalIF":4.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estradiol replacement attenuates alendronate-associated adverse effects on alveolar bone repair in ovariectomized rats","authors":"Pedro H. C. Isaias,&nbsp;Paulo G. B. Silva,&nbsp;Isabelly V. do Nascimento,&nbsp;Raul A. D. A. da Silva,&nbsp;Thayla M. do C. Sousa,&nbsp;Ana J. A. de Vasconcelos,&nbsp;José V. M. Lemos,&nbsp;Fabrício B. Sousa,&nbsp;Ana P. N. N. Alves,&nbsp;Mário R. L. Mota","doi":"10.1002/jper.70088","DOIUrl":"10.1002/jper.70088","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Sodium alendronate (ALN) is widely used to treat postmenopausal osteoporosis, but both estrogen deficiency and antiresorptive therapy may impair alveolar bone repair after tooth extraction. A clinically relevant but insufficiently explored scenario involves estrogen-deficient individuals receiving hormone replacement therapy (HRT) who subsequently initiate ALN treatment. This study investigated whether estradiol valerate (E) replacement attenuates ALN-associated disturbances in alveolar bone repair in ovariectomized (OVX) rats.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Sixty-three female Wistar rats were divided into sham-operated (SHAM) or OVX groups and treated with ALN (5 or 10 mg/kg) or 0.9% sodium chloride saline solution (SAL), with or without E replacement (0.8 mg/kg). The left first molar was extracted, and alveolar repair was evaluated 28 days later through clinical, radiographic, histological, and immunohistochemical (tumor necrosis factor alpha [TNF-α], receptor activator of nuclear factor kappa-B ligand [RANKL], osteoprotegerin [OPG], and tartrate-resistant acid phosphatase [TRAP]) analyses.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;OVX increased body mass and reduced uterine wet mass (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Radiographically, ALN-treated groups exhibited increased socket radiolucency, particularly at the higher dose (&lt;i&gt;p&lt;/i&gt; = 0.040). Microscopic analysis revealed more empty osteocyte lacunae (&lt;i&gt;p&lt;/i&gt; = 0.012) and connective tissue (&lt;i&gt;p&lt;/i&gt; = 0.010), particularly in ALN-treated OVX groups. OVX and ALN increased TNF-α, RANKL, and TRAP expression and reduced OPG levels (&lt;i&gt;p&lt;/i&gt; = 0.004; = 0.002; = 0.030; &lt; 0.001). E replacement mitigated these effects and reduced type III collagen deposition (&lt;i&gt;p&lt;/i&gt; &lt; 0.001).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Chronic ALN impaired alveolar bone repair, exacerbated by estrogen deficiency. HRT with E partially attenuated these effects without fully restoring healing. The persistent remodeling disturbances highlight the relevance of hormonal status for dental risk assessment in patients receiving bisphosphonates.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Osteoporosis is common in postmenopausal women due to reduced estrogen levels and leads to weaker bones. Alendronate is widely prescribed to lower fracture risk, but it may interfere with bone healing after dental procedures such as tooth extraction. Using a rat mode","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 6","pages":"1271-1284"},"PeriodicalIF":4.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of severe periodontitis and diabetes mellitus on recurrent cardiovascular outcomes","authors":"Stefan Reichert,&nbsp;Axel Schlitt,&nbsp;Selina Rehm,&nbsp;Susanne Schulz","doi":"10.1002/jper.70086","DOIUrl":"10.1002/jper.70086","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This post hoc analysis of the Periodontitis and Coronary Heart Disease study (ClinicalTrials.gov Identifier: NCT01045070) aimed to determine the association between diabetes and recurrent cardiovascular events (CVEs) in patients with cardiovascular disease (CVD) and severe periodontitis. Another objective was to examine the link between diabetes and severe periodontitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A cohort of 1,002 stationary patients with angiographically proven CVD was included. The patients were examined for the prevalence of diabetes (severity levels: diet, oral antidiabetic drugs, and insulin) and severe periodontitis (≥30% of teeth with ≥5 mm of proximal attachment loss). Recurrent CVEs were summarized as a combined endpoint (myocardial infarction, stroke/transient ischemic attack, cardiovascular death, and stroke-related death). After a 10-year follow-up period, survival analyses were carried out. Hazard ratios (HRs) were adjusted for known cardiac risk factors using Cox regression.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 792 patients completed follow-up. The overall incidence of the combined endpoint was 42.8%. The highest HR for CVEs was observed in patients with both diabetes and severe periodontitis (HR = 2.19, 95% confidence interval [CI] 1.59-3.02). HRs were lower in subjects with only periodontitis (HR = 1.52, 95% CI = 1.14-2.04) or only diabetes (HR = 1.88, 95% CI = ∖1.35-2.63). Patients with diabetes who took drugs or required insulin were more likely to have severe periodontitis than patients without diabetes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patients with diabetes or severe periodontitis were at an increased risk of recurrent CVEs. An association was also found between diabetes and severe periodontitis prevalence.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Clinical trial registration&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;ClinicalTrials.gov Identifier: NCT01045070&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontitis is a serious gum disease that damages the tissue that supports teeth. In its final stage, it can result in tooth loss. Furthermore, studies have shown an association between periodontitis and cardiovascular disease (CVD) and diabetes mellitus. The objective of this study was to investigate the relationship between diabetes and recurrent cardiovascula","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 6","pages":"1360-1371"},"PeriodicalIF":4.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrolyzed saline as an alternative to chlorhexidine: Antimicrobial and biofilm volume outcomes in a 4-day non-brushing randomized controlled clinical trial","authors":"Katja Povšič,&nbsp;Haris Munjaković,&nbsp;Naiera Zayed,&nbsp;Wim Teughels,&nbsp;Katja Seme,&nbsp;Aleš Fidler,&nbsp;Rok Gašperšič","doi":"10.1002/jper.70070","DOIUrl":"10.1002/jper.70070","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The biofilm-inhibitory effects of electrolyzed saline (EOS) vary widely due to differences in formulations and treatment methods. This study analyzed the impact of EOS on key oral microbial species and used serial 3D-intraoral scans to evaluate its effects on &lt;i&gt;de novo&lt;/i&gt; biofilm formation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This was a double-blind, randomized, placebo-controlled, cross-over, 4-day, non-brushing, plaque-regrowth study on periodontally healthy individuals. Each subject participated in three trial arms. During each 4-day arm, the subjects refrained from mechanical oral hygiene. Instead, they rinsed their oral cavities twice-daily with EOS, 0.12% chlorhexidine (CHX), or placebo. &lt;i&gt;De novo&lt;/i&gt; plaque accumulation after 4 days was assessed as the primary outcome using the Turesky Modification of the Quigley-Hein Plaque Index (TMQHPI) and the volumetric plaque index (VPI). qPCR analyses of key-microbial species and measurements of active-matrix-metalloproteinase-8 (aMMP-8) in gingival crevicular fluid were performed to complement the clinical data.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The biofilm-inhibitory effect of CHX was superior to that of EOS at the level of TMQHPlI and VPI, although both significantly reduced biofilms compared with placebo. The broad-spectrum antimicrobial effect of CHX caused significant reductions in overall bacterial loads, while the action of EOS was more selective. Both CHX and EOS markedly reduced the bacterial loads of &lt;i&gt;Tannerella forsythia&lt;/i&gt;; CHX remained more effective against &lt;i&gt;Treponema denticola&lt;/i&gt;. In contrast, only EOS demonstrated stronger antimicrobial effects against &lt;i&gt;Fusobacterium nucleatum&lt;/i&gt; and &lt;i&gt;Prevotella intermedia&lt;/i&gt; while showing no significant impact on periodontal commensals. No significant effects on aMMP-8 were observed.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;EOS showed substantial, but inferior biofilm-inhibitory, effects compared with CHX. However, EOS had more selective and dysbiosis-controlling effects than CHX.&lt;/p&gt;\u0000 \u0000 &lt;p&gt;The clinical trial was registered at Clintrials.gov under no. NCT05709015.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study investigated the effectiveness of electrolyzed saline (EOS) in preventing biofilm build-up on teeth. The efficacy of EOS mouthwash was compared with a positive control (chlorhexidine, CHX) and a negative con","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 6","pages":"1231-1242"},"PeriodicalIF":4.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of implant platform apico-coronal position on the bone level of adjacent teeth","authors":"Yu-Ting Yeh,&nbsp;Vincent Li,&nbsp;Caroline Chen,&nbsp;Hsuan-Hung Chen,&nbsp;Guo-Hao Lin,&nbsp;Richard T. Kao,&nbsp;Effie Ioannidou","doi":"10.1002/jper.70056","DOIUrl":"10.1002/jper.70056","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This retrospective study aimed to evaluate the influence of the implant platform apico-coronal position on the crestal bone level of adjacent teeth, focusing on the anterior and premolar regions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Ninety-six patients with 117 implants were included. The vertical distance from the implant platform to the crestal bone level of adjacent teeth was measured, and bone level changes were assessed from loading to the last follow-up. The implant position was categorized into two subgroups based on the vertical distance (≤2 or &gt; 2 mm). Associations between vertical distance, bone loss on adjacent teeth and implants, and other variables were analyzed using linear regression and multivariate generalized estimating equations (GEE).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Linear regression showed a significant association between implant vertical distance and bone loss on adjacent teeth, but not at implant sites. Multivariate GEE analysis revealed that a vertical distance of &gt; 2 mm, a convex prosthesis emergence profile, and female sex were significantly associated with a greater bone loss on adjacent teeth. After adjusting for sex, implants with a vertical distance of &gt; 2 mm combined with a convex profile presented greater bone loss compared with a concave profile. In contrast, when the vertical distance was ≤2 mm, no statistically significant difference was found between implants with convex or concave profiles.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;An implant positioned more than 2 mm vertically relative to the crestal bone level of the adjacent teeth was associated with a greater crestal bone loss on these teeth. This suggests that clinicians should carefully consider vertical implant positioning to prevent bone loss around the adjacent teeth.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study looked at how the vertical position of a dental implant affects the bone levels around nearby natural teeth, especially in the front and premolar areas of the mouth. Our team reviewed records from 96 patients who received a total of 117 implants. We measured the distance between the top of each implant and the bone level of the teeth next to it. The implants were grouped into two categories: those placed 2 millimeters or less below the bone level of nearby teeth, and those placed more than 2 millimeters below. The results showed that when implants were placed more than 2 millimeters below the nearby teeth, there was more bone loss around thos","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 6","pages":"1219-1230"},"PeriodicalIF":4.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}