Behçet's disease modifies the gingival inflammatory response.

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Selin Sahinkaya,Melis Yilmaz,Ekin Yay,Hilal Toygar,Nur Balci,Dursun Dorukhan Altinisik,Zekayi Kutlubay,Alpdogan Kantarci
{"title":"Behçet's disease modifies the gingival inflammatory response.","authors":"Selin Sahinkaya,Melis Yilmaz,Ekin Yay,Hilal Toygar,Nur Balci,Dursun Dorukhan Altinisik,Zekayi Kutlubay,Alpdogan Kantarci","doi":"10.1002/jper.24-0182","DOIUrl":null,"url":null,"abstract":"BACKGROUND\r\nBehçet's disease (BD) pathogenesis involves severe outcomes such as blindness, central nervous system manifestations, and deep venous thrombosis that impacts systemic and local inflammatory changes. We tested the hypothesis that BD negatively affects gingival health and increases the severity of gingivitis.\r\n\r\nMETHODS\r\nThe study included 37 BD patients with gingivitis without any sign of periodontitis. Systemically healthy 19 patients with gingivitis (G) and 20 periodontally and systemically healthy individuals (C) were recruited as controls. BD patients were further grouped as stable and unstable based on their responses to BD treatment. Clinical periodontal parameters were measured to determine the impact of BD on gingival health. Serum and saliva levels of ELA-2 (neutrophil elastase-2), SLPI (secretory leukocyte protease inhibitor), α1-AT (alpha1-anti-trypsin), VEGF (vascular endothelial growth factor), IL-6 (interleukin-6), IL-8 (interleukin-8), and TNF-α (tumor necrosis factor alpha) were analyzed using multiplex immunoassay to measure the systemic and local inflammatory impact of BD.\r\n\r\nRESULTS\r\nPlaque index (PI), probing pocket depth (PPD), and bleeding on probing (BOP) were significantly higher in the BD group than in the controls (p < 0.05). IL-6 was higher in both serum and saliva in the BD group than in the G group (p < 0.05). ELA-2 levels in saliva were higher in the stable BD group than in the controls, while TNF-α and SLPI were statistically significantly higher in BD than in the control (p < 0.05). Salivary α1-AT level was statistically lower in the BD group compared to the control group.\r\n\r\nCONCLUSION\r\nOur study suggested that the gingival inflammatory profile was impaired in patients with BD.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"49 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of periodontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jper.24-0182","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

BACKGROUND Behçet's disease (BD) pathogenesis involves severe outcomes such as blindness, central nervous system manifestations, and deep venous thrombosis that impacts systemic and local inflammatory changes. We tested the hypothesis that BD negatively affects gingival health and increases the severity of gingivitis. METHODS The study included 37 BD patients with gingivitis without any sign of periodontitis. Systemically healthy 19 patients with gingivitis (G) and 20 periodontally and systemically healthy individuals (C) were recruited as controls. BD patients were further grouped as stable and unstable based on their responses to BD treatment. Clinical periodontal parameters were measured to determine the impact of BD on gingival health. Serum and saliva levels of ELA-2 (neutrophil elastase-2), SLPI (secretory leukocyte protease inhibitor), α1-AT (alpha1-anti-trypsin), VEGF (vascular endothelial growth factor), IL-6 (interleukin-6), IL-8 (interleukin-8), and TNF-α (tumor necrosis factor alpha) were analyzed using multiplex immunoassay to measure the systemic and local inflammatory impact of BD. RESULTS Plaque index (PI), probing pocket depth (PPD), and bleeding on probing (BOP) were significantly higher in the BD group than in the controls (p < 0.05). IL-6 was higher in both serum and saliva in the BD group than in the G group (p < 0.05). ELA-2 levels in saliva were higher in the stable BD group than in the controls, while TNF-α and SLPI were statistically significantly higher in BD than in the control (p < 0.05). Salivary α1-AT level was statistically lower in the BD group compared to the control group. CONCLUSION Our study suggested that the gingival inflammatory profile was impaired in patients with BD.
贝赫切特病会改变牙龈炎症反应。
背景贝赫切特病(BD)的发病机制包括严重的后果,如失明、中枢神经系统表现和深静脉血栓形成,这些都会影响全身和局部的炎症变化。我们测试了 BD 对牙龈健康产生负面影响并增加牙龈炎严重程度的假设。19 名全身健康的牙龈炎患者(G)和 20 名牙周和全身健康者(C)作为对照。根据对 BD 治疗的反应,将 BD 患者进一步分为稳定型和不稳定型。测量临床牙周参数以确定 BD 对牙龈健康的影响。使用多重免疫测定法分析血清和唾液中 ELA-2(中性粒细胞弹性蛋白酶-2)、SLPI(分泌型白细胞蛋白酶抑制剂)、α1-AT(α1-抗胰蛋白酶)、VEGF(血管内皮生长因子)、IL-6(白细胞介素-6)、IL-8(白细胞介素-8)和 TNF-α(肿瘤坏死因子α)的水平,以衡量 BD 对全身和局部炎症的影响。结果BD组的水泡指数(PI)、探诊袋深度(PPD)和探诊出血量(BOP)明显高于对照组(P < 0.05)。BD 组血清和唾液中的 IL-6 均高于 G 组(P < 0.05)。BD稳定组唾液中的ELA-2水平高于对照组,而BD组的TNF-α和SLPI在统计学上显著高于对照组(P < 0.05)。结论我们的研究表明,BD 患者的牙龈炎症特征受损。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信