{"title":"A population‐based study on the associations of thyroid cancer with chronic periodontitis","authors":"Tzong‐Hann Yang, Yen‐Fu Cheng, Herng‐Ching Lin, Chin‐Shyan Chen","doi":"10.1002/jper.24-0311","DOIUrl":null,"url":null,"abstract":"BackgroundEmerging concerns link periodontitis to an array of cancers, notably thyroid cancer, though investigations into these associations are still in the nascent stages. This population‐based study aimed to investigate the association of thyroid cancer with chronic periodontitis using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010).MethodsThis case‐control study utilized LHID2010, selecting 2,775 patients diagnosed with thyroid cancer, matched with 8,325 controls based on age, sex, income, and the presence of diabetes, hypertension, hyperlipidemia, human papillomavirus infection, and tobacco use disorder using propensity‐score matching. Multivariate logistic regression models were used to evaluate the association of thyroid cancer with chronic periodontitis.ResultsA chi‐squared analysis demonstrated a significant disparity in the prevalence of chronic periodontitis between those diagnosed with thyroid cancer and the controls, with prevalence rates of 38.5% and 24.1% respectively, and a <jats:italic>p</jats:italic>‐value less than 0.001. The odds ratio (OR) for having prior chronic periodontitis among patients with thyroid cancer compared to controls was 1.991, with a 95% confidence interval (CI) of 1.816–2.184 and a <jats:italic>p</jats:italic>‐value less than 0.001. The association was similar between sexes, yielding adjusted ORs of 1.991 (95% CI = 1.816∼2.184) for men and 1.962 (95% CI = 1.765−2.182) for women, indicating a statistically significant higher prevalence of chronic periodontitis in both male and female patients diagnosed with thyroid cancer compared to their control counterparts.ConclusionThe findings highlight chronic periodontitis as a potential risk factor for thyroid cancer, underscoring the importance of integrated health surveillance and preventive strategies that encompass oral health.Plain Language SummaryThis study aimed to explore the link between thyroid cancer and chronic periodontitis. Using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010), we selected 2,775 patients with thyroid cancer and matched them with 8,325 individuals without the disease based on age, sex, income, and other health conditions such as diabetes, hypertension, high cholesterol, HPV infection, and smoking habits. The study used statistical models to examine the relationship between thyroid cancer and chronic periodontitis. The findings showed that 38.5% of thyroid cancer patients had chronic periodontitis, compared to 24.1% of the control group. The odds of having chronic periodontitis were nearly twice as high in thyroid cancer patients. This pattern was consistent for both men and women. The study underscores the strong connection between chronic periodontitis and thyroid cancer, emphasizing the importance of raising public awareness about the potential risks of periodontitis.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of periodontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jper.24-0311","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
BackgroundEmerging concerns link periodontitis to an array of cancers, notably thyroid cancer, though investigations into these associations are still in the nascent stages. This population‐based study aimed to investigate the association of thyroid cancer with chronic periodontitis using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010).MethodsThis case‐control study utilized LHID2010, selecting 2,775 patients diagnosed with thyroid cancer, matched with 8,325 controls based on age, sex, income, and the presence of diabetes, hypertension, hyperlipidemia, human papillomavirus infection, and tobacco use disorder using propensity‐score matching. Multivariate logistic regression models were used to evaluate the association of thyroid cancer with chronic periodontitis.ResultsA chi‐squared analysis demonstrated a significant disparity in the prevalence of chronic periodontitis between those diagnosed with thyroid cancer and the controls, with prevalence rates of 38.5% and 24.1% respectively, and a p‐value less than 0.001. The odds ratio (OR) for having prior chronic periodontitis among patients with thyroid cancer compared to controls was 1.991, with a 95% confidence interval (CI) of 1.816–2.184 and a p‐value less than 0.001. The association was similar between sexes, yielding adjusted ORs of 1.991 (95% CI = 1.816∼2.184) for men and 1.962 (95% CI = 1.765−2.182) for women, indicating a statistically significant higher prevalence of chronic periodontitis in both male and female patients diagnosed with thyroid cancer compared to their control counterparts.ConclusionThe findings highlight chronic periodontitis as a potential risk factor for thyroid cancer, underscoring the importance of integrated health surveillance and preventive strategies that encompass oral health.Plain Language SummaryThis study aimed to explore the link between thyroid cancer and chronic periodontitis. Using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010), we selected 2,775 patients with thyroid cancer and matched them with 8,325 individuals without the disease based on age, sex, income, and other health conditions such as diabetes, hypertension, high cholesterol, HPV infection, and smoking habits. The study used statistical models to examine the relationship between thyroid cancer and chronic periodontitis. The findings showed that 38.5% of thyroid cancer patients had chronic periodontitis, compared to 24.1% of the control group. The odds of having chronic periodontitis were nearly twice as high in thyroid cancer patients. This pattern was consistent for both men and women. The study underscores the strong connection between chronic periodontitis and thyroid cancer, emphasizing the importance of raising public awareness about the potential risks of periodontitis.
背景人们越来越关注牙周炎与一系列癌症(尤其是甲状腺癌)之间的关系,但对这些关系的调查仍处于初级阶段。方法这项病例对照研究利用台湾纵向健康保险数据库2010(LHID2010),选择了2,775名确诊为甲状腺癌的患者,根据年龄、性别、收入以及是否患有糖尿病、高血压、高脂血症、人类乳头瘤病毒感染和烟草使用障碍等因素,利用倾向分数匹配法与8,325名对照组进行匹配。结果卡方分析表明,甲状腺癌患者和对照组的慢性牙周炎患病率存在显著差异,患病率分别为38.5%和24.1%,P值小于0.001。与对照组相比,甲状腺癌患者患慢性牙周炎的几率比(OR)为1.991,95%置信区间(CI)为1.816-2.184,P值小于0.001。男女之间的相关性相似,男性的调整 OR 值为 1.991(95% CI = 1.816∼2.184),女性为 1.962(95% CI = 1.765-2.182),这表明与对照组患者相比,男性和女性甲状腺癌患者的慢性牙周炎患病率在统计学上都显著较高。本研究旨在探讨甲状腺癌与慢性牙周炎之间的联系。通过台湾纵向健康保险数据库2010(LHID2010),我们选取了2,775名甲状腺癌患者,并根据年龄、性别、收入和其他健康状况(如糖尿病、高血压、高胆固醇、HPV感染和吸烟习惯),将他们与8,325名无甲状腺癌患者进行配对。研究使用统计模型来检验甲状腺癌与慢性牙周炎之间的关系。研究结果显示,38.5%的甲状腺癌患者患有慢性牙周炎,而对照组的这一比例为24.1%。甲状腺癌患者患慢性牙周炎的几率几乎是对照组的两倍。这种模式在男性和女性中都是一致的。这项研究强调了慢性牙周炎与甲状腺癌之间的密切联系,强调了提高公众对牙周炎潜在风险认识的重要性。