Journal of periodontology最新文献

{"title":"Biomaterial used to counteract ridge reduction following the removal of adjacent teeth: A randomized controlled multicenter study","authors":"Denis Cecchinato, Enrico Corrà, Eriberto Bressan, Marika Gervasi, Marco Menoncin, Enrico Savio, Marco Toia","doi":"10.1002/jper.70084","DOIUrl":"10.1002/jper.70084","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alveolar ridge resorption (ARP) is a well-recognized consequence of tooth extraction, and multiple adjacent extractions may lead to greater ridge reduction than single-tooth extractions. This multicenter randomized controlled trial aimed to assess ridge remodeling after removing 2 adjacent teeth and whether socket grafting with deproteinized bovine bone mineral with collagen (DBBM-C) plus a collagen membrane could counteract the ridge reduction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty-two patients requiring 2 adjacent tooth extractions were randomly assigned to either Test (DBBM-C graft + collagen membrane) or Control (natural healing). Impressions were taken immediately after extraction and at 6 months, and models were analyzed to measure changes in horizontal ridge width (bucco-lingual at 3 mm below the crest) and vertical ridge height (buccal and lingual).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 6 months, grafted sites had significantly less ridge reduction than controls. Horizontal ridge width reduction averaged 57.7% in Control versus 23.0% in Test (<i>p</i> < 0.001). Vertical height loss was also greater in controls (buccal 3.0 mm vs. 1.5 mm; lingual 2.2 mm vs. 1.3 mm; <i>p</i> < 0.001). Both mesial and distal sockets benefited similarly from grafting, with comparable preservation at each site.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Filling adjacent extraction sockets with DBBM-C and covering with a collagen membrane significantly reduced horizontal and vertical alveolar ridge resorption compared to unassisted healing. This approach effectively preserves bone volume after multiple tooth extractions, which may facilitate later implant placement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>When 2 neighboring teeth are removed, the area tends to shrink in width and height as it heals. This bone loss can make it more difficult to place dental implants later. In this study, we tested a method to help maintain the bone after removing 2 adjacent teeth. In the Test group, the empty tooth sockets were filled with a bone graft material (deproteinized bovine bone mineral and collagen) and covered with a collagen membrane. In the Control group, the sites were left to heal physiologically. A total of 42 patients participated, each needing 2 side-by-side teeth removed. After 6 months of healing, we compared models of the patients from right after the extractions t","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1481-1490"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulators, associated or not with systemic antibiotics, to treat periodontitis: A 1-year multicenter, placebo-controlled, double-blind, randomized clinical trial","authors":"Nidia C. Castro dos Santos, Rafael N. de Brito Silva, Fernanda S. Colombo, Ingrid Oliveira-Cardoso, Lina J. Súarez, Rodrigo Martins, Luciene C. de Figueiredo, Heitor Marques Honório, Ademir Melo Leite Filho, Flavia A. C. Furlaneto, Michel R. Messora, Monique Furukawa, José Roberto Cortelli, Emanuel Silva Rovai, Magda Feres","doi":"10.1002/jper.70081","DOIUrl":"10.1002/jper.70081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Immunomodulatory agents such as omega-3 (ω-3) and low-dose aspirin (ASA) have been proposed as effective adjuncts in the treatment of periodontitis. However, they still lack long-term studies and head-to-head evaluation with metronidazole (MTZ) and amoxicillin (AMX), the adjunct protocol with the strongest scientific evidence of clinical benefit. This study aimed to evaluate the clinical effects of (ω)-3 and ASA, alone or combined with MTZ + AMX, to treat periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adults with stage III/IV periodontitis were randomly allocated to receive: (i) subgingival instrumentation (SI) and placebo; (ii) SI with adjunctive MTZ (400 mg) + AMX (500 mg) three times/day for 14 days (ATB); (iii) SI with adjunctive ω-3 (3 g) + ASA (100 mg/day) for 6 months (IM); and (iv) SI with adjunctive ATB and IM (ATB + IM). The patients were followed for 1 year post-therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>109 patients were included. At 1 year, 58.6%, 57.7%, and 57.1% of patients receiving ATB, IM, and ATB+IM, respectively, achieved the treatment endpoint [≤4 sites with a probing depth (PD) of ≥5 mm], compared with 23.1% in the SI group (<i>p</i> = 0.023). Each adjunctive therapy resulted in a greater reduction in the number of sites with PD≥5 mm compared with SI (<i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Adjunctive ATB, IM, or ATB+IM each provided clinically meaningful benefits beyond mechanical therapy. The results suggested no added benefit from combining ATB and IM. These findings support MTZ + AMX or ω-3 + ASA, without routine combination, as effective adjuncts in periodontal treatment and provide a basis for precision-based trials and data-driven models to identify patients most likely to benefit from each approach. ensaiosclinicos.gov.br RBR-7nh566t</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>This study explored whether adding antibiotics or anti-inflammatory supplements (omega-3 and low-dose aspirin), either alone or in combination, could enhance the results of subgingival instrumentation (non-surgical periodontal therapy) in patients with severe periodontitis. All participants received the standard periodontal treatment and were randomly assigned to also take a placebo, antibiotics, omega-3 with aspirin, or a combination of both therapies. After 1 year, patients who received any of the additional therapies showed greater ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1454-1466"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Donald F. Adams, DDS, MS, FACD","authors":"","doi":"10.1002/jper.70138","DOIUrl":"10.1002/jper.70138","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148286399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does timing of systemic antibiotics influence periodontal treatment outcomes? A randomized clinical trial","authors":"Daiane Fermiano, Eduardo de Souza Oliveira, Maria Josefa Mestnik, Luciene C. Figueiredo, Takahiko Shiba, Shunsuke Matsumura, Edson de Sousa, Helio Doyle, Rafael Oliveira Dias, Marcelo de Faveri, Magda Feres","doi":"10.1002/jper.70057","DOIUrl":"10.1002/jper.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study is to determine whether the timing of metronidazole (MTZ) and amoxicillin (AMX) administration, relative to scaling and root planing (SRP), influences the clinical and microbiological outcomes of periodontal treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this double-blind, placebo-controlled, randomized clinical trial, subjects with stage III/IV periodontitis were assigned to receive SRP over 14 days with either (1) MTZ+AMX three times a day (TID) during SRP followed by placebo (<i>early</i> antibiotic group) or (2) placebo during SRP followed by MTZ + AMX TID immediately after SRP (<i>late</i> antibiotic group). Clinical parameters (probing depth [PD], clinical attachment level [CAL], visible plaque, bleeding on probing, suppuration) were recorded at baseline, 3 months and 1 year. Subgingival biofilm samples from nine sites per subject were individually analyzed using checkerboard DNA–DNA hybridization targeting 40 bacterial species. Bacterial correlation networks were constructed using SparCC and visualized in Cytoscape based on the bacterial abundance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-eight subjects were included in the study, with 34 per group. Both groups achieved comparable clinical improvements. Approximately 60% of participants in each group reached the primary treatment endpoint at 1 year (≤ 4 sites with PD ≥ 5 mm at 1 year; <i>p</i> > 0.05), and the reductions in PD and CAL did not differ significantly between groups (<i>p</i> > 0.05). Microbiologically, the <i>early</i> antibiotic group demonstrated faster and more pronounced ecological reorganization, with reduced centrality of red and orange complex species and earlier integration of health-associated taxa such as <i>Actinomyces</i> spp. In contrast, the <i>late</i> group showed slower microbial restructuring, with <i>Actinomyces</i> taxa remaining entangled with orange-complex organisms and persistent dysbiotic clusters dominated by <i>Fusobacterium</i> subspecies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While the timing of antibiotic administration relative to SRP did not influence the overall clinical efficacy of periodontal treatment, initiating antibiotics on the first day of mechanical debridement promoted a more rapid and beneficial restructuring of the subgingival microbial community.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>When treating severe gum ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1395-1406"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of artificial intelligence-based deep learning models in detecting furcation involvement: A systematic review and meta-analysis","authors":"Momen A. Atieh, Maanas Shah, Abeer Hakam, Omar Al-Karadsheh, Siraj Zabadi, Fawaghi AlAli, Nisheta Sachdev, Andrew Tawse-Smith, Nabeel H. M. Alsabeeha","doi":"10.1002/jper.70055","DOIUrl":"10.1002/jper.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Furcation involvement complicates the management of periodontitis and increases the risk of tooth loss. Conventional methods of detection, such as probing and two-dimensional radiographs, are limited by operator variability and anatomical complexity. Deep learning has shown a potential to detect furcation involvement on radiographic images. The aim of this review was to systematically evaluate the diagnostic potentials of deep learning models in detecting furcation involvement on radiographic images.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Systematic search was conducted in PubMed, EMBASE, CENTRAL, ClinicalTrials.gov and ProQuest for studies published from 2010 to September 2025. Two reviewers independently screened studies, extracted data, and assessed quality using QUADAS-2. Diagnostic metrics (sensitivity, specificity, F1-score, area under the curve (AUC)) were pooled using random-effects meta-analysis. Heterogeneity and publication bias were assessed via <i>I</i><sup>2</sup> statistics, meta-regression, and funnel plots.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight studies, including 7814 radiographs of 12,373 molars (periapical, panoramic, cone-beam computed tomography), were analyzed. Deep learning models demonstrated high accuracy: sensitivity 0.93, specificity 0.94, diagnostic odds ratio (DOR) 187, AUC 0.97 with mandibular molars reflecting higher accuracy (sensitivity 0.96, specificity 0.97, DOR 631, AUC 0.99). Fagan plot analysis indicated strong clinical utility. Meta-regression showed no significant effect of dataset type, augmentation, or number of annotators. No publication bias was detected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Deep learning models show promising accuracy in detecting furcation involvement, particularly in mandibular molars, comparable to expert clinicians. Further refinement with larger, diverse datasets is needed to reduce false positives and enable safe clinical integration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>Furcation involvement, a condition where the bone between the roots of a tooth is lost, makes managing gum disease more difficult and increases the risk of tooth loss. Clinical probing remains a reliable and essential method for detecting this condition, while dental X-rays can provide complementary information, particularly in complex cases. This study reviewed the use of deep learning, a type of artificial intelligence (AI), to detect furcation involvement on dental X-rays. Data from eight studies, including more than 7,","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1559-1574"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal regeneration with enamel matrix derivative and decortication: A retrospective analysis of 1-year clinical and radiographic outcomes","authors":"Margherita Giorgia Liguori,&nbsp;Leonardo Mancini,&nbsp;Cosimo Rupe,&nbsp;Gianluca Vittorini Orgeas,&nbsp;Cristiano Littarru,&nbsp;Carlo Lajolo,&nbsp;Alessandro Crea","doi":"10.1002/jper.70067","DOIUrl":"10.1002/jper.70067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Intrabony periodontal defects present a clinical challenge. Decortication, also called intramarrow penetration (IMP), intended to stimulate angiogenesis and to enhance the healing environment, has demonstrated benefits in bone augmentation but remains insufficiently investigated in periodontal regenerative procedures, especially in combination with enamel matrix derivative (EMD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included patients treated with EMD alone (control group) or with EMD combined with IMP (test group). The primary outcome was clinical attachment level (CAL) gain at 12 months. Secondary outcomes included probing pocket depth (PPD), gingival recession (REC), keratinized tissue width (KTW), and radiographic parameters such as defect depth (rDD), defect width (rDW), and defect angle (rANG). Linear regression with generalized estimating equations (GEE) was used to account for clustering, with Bonferroni correction for multiple comparisons. The significance was set at α = 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 29 patients (39 teeth) were included. Both groups exhibited statistically significant improvements in clinical and radiographic parameters between baseline and 12 months (<i>p</i> &lt; 0.05). In the test group, the mean PPD decreased by 3.86 ± 1.73 mm, the CAL gain was 3.18 ± 1.30 mm, and the REC increased by 0.68 ± 1.21 mm; radiographically, rDD and rDW were significantly reduced, whereas rANG did not change significantly. Similarly, in the control group, PPD decreased by 3.47 ± 1.33 mm, CAL gain was 2.82 ± 1.29 mm, REC increased by 0.65 ± 1.00 mm, and significant reductions in rDD and rDW were observed. No statistically significant differences were found between the two groups for any parameter at 12 months (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The adjunctive use of IMP did not significantly enhance the clinical or radiographic outcomes achieved with EMD alone. However, the comparable outcomes achieved in more challenging baseline conditions indicate that the technique merits further investigation in future randomized controlled studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1442-1453"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oral microbial diversity and periodontitis in a nationally representative U.S. population: A cross-sectional study","authors":"Rui Pu,&nbsp;Zhikang Wang,&nbsp;Yunxuan Chen,&nbsp;Danhong Zhou,&nbsp;Guoli Yang,&nbsp;Zhiwei Jiang","doi":"10.1002/jper.70101","DOIUrl":"10.1002/jper.70101","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To investigate the association between salivary oral microbiome diversity and periodontitis in a nationally representative U.S. population.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 5323 participants with both periodontal examination and oral microbiome data from NHANES 2009–2012 were included. Periodontitis was defined using 2012 CDC/AAP criteria. Four alpha diversity indices (operational taxonomic unit [OTU] richness, Faith's phylogenetic diversity [FPD], the Shannon-Weiner index [SWI], and the inverse Simpson index [ISI]) were calculated. Beta diversity metrics (Bray–Curtis, weighted and unweighted UniFrac) were assessed using PERMANOVA for group comparisons and hierarchical clustering to identify subgroups. Ordered logistic regression was employed to examine the associations between periodontitis severity and microbial alpha diversity, beta diversity clusters, and bacterial genus abundances.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Higher alpha diversity was positively associated with greater periodontitis severity (OTU richness: OR = 1.01, 95%CI: 1.01–1.02; FPD: OR = 1.21, 95%CI: 1.19–1.24; SWI: OR = 2.03, 95%CI: 1.81–2.30; ISI: OR = 16.61, 95%CI: 1.75–157.59). Beta diversity analyses revealed significant community compositional differences across periodontitis severity levels (PERMANOVA, all &lt;i&gt;p &lt;/i&gt;= 0.001). Hierarchical clustering identified distinct microbial subgroups with varying odds of belonging to more severe periodontitis levels. Eighty-two bacterial genera were significantly associated with periodontitis, including taxa showing strong positive associations consistent with the red and orange complexes (e.g., &lt;i&gt;Porphyromonas, Tannerella, Treponema&lt;/i&gt;) and taxa exhibiting negative associations involving health-associated genera (e.g., &lt;i&gt;Rothia&lt;/i&gt;, &lt;i&gt;Veillonella&lt;/i&gt;).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Salivary microbiome diversity, particularly higher alpha diversity and specific beta diversity clusters, was associated with periodontitis severity, supporting its potential relevance as a non-invasive indicator of periodontal health status.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This national study examined the relationship between the types and quantities of microbes present in saliva and the severity of periodontitis in more than 5,300 U.S. adults. We found that the more diverse the microbial community in a person's saliva—meaning a greater variety and number of different types—the more severe their periodontitis tended to be. We also fo","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1575-1586"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological patterns of buccal bone plate in the maxillary esthetic zone: A cross-sectional study","authors":"Danijel Domic,&nbsp;Diogo Moreira Rodrigues,&nbsp;Emilio Couso-Queiruga,&nbsp;Eliane Porto Barboza,&nbsp;Mariano Sanz,&nbsp;Christian Ulm,&nbsp;Gustavo Avila-Ortiz","doi":"10.1002/jper.70071","DOIUrl":"10.1002/jper.70071","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This cross-sectional study aimed to characterize buccal bone plate (BBP) morphological patterns in anterior maxillary teeth and to evaluate their association with other phenotypical and local anatomical characteristics.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Two examiners conducted a qualitative assessment of BBP morphological patterns using cone-beam computed tomography scans from healthy adults. Validated cases were employed to determine numerical thresholds for buccal bone thickness (BBT) for each BBP category at different apicocoronal levels. Periodontal phenotypical- and anatomical variables, including BBT, gingival thickness (GT), keratinized tissue width (KTW), supracrestal tissue height (STH), distance from the cementoenamel junction to the bone crest (CEJ-BC), sagittal root position (SRP), and tooth shape (TS), were documented through radiographic, clinical, and photographic evaluations.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Four distinct BBP morphological patterns were identified and categorized as rectangular (39.2%), inverted triangular (23.6%), triangular (14.4%), or hourglass (22.8%). Significant variations in mean BBT values across the 4 BBP patterns were observed at different apicocoronal levels (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Associations were found between BBP morphological patterns and GT, SRP, and TS (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Multilevel logistic regression analysis showed that BBT, regardless of the vertical level, and GT at 2 mm apical to the gingival margin were key predictors of BBP shape. The inverted triangular pattern was linked to a thicker gingival phenotype and was mostly observed in lateral incisors.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Four BBP patterns were identified, and a novel classification system was devised. Associations between different categories and key phenotypic and anatomical variables, including BBT, GT, SRP, and TS, were observed. This classification can be used to aid diagnostic processes, and in the planning and execution of various treatments in the anterior maxilla, as well as in future research.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The bone that supports the upper front teeth plays an important role in maintaining oral health and ensuring the success of dental treatments. Traditionally, this bone has been described using simple linear measurements. In the present study, we analyzed the entire bone plate and identified ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1503-1515"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological and periodontal benefits of prebiotic polydextrose in rats with induced periodontitis","authors":"Raquel de S. F. Nassar,&nbsp;Marcella C. Ribeiro,&nbsp;Ana Carolina P. Hernandes,&nbsp;Laura Z. Gianduzzo,&nbsp;Vanessa de P. S. Pereira,&nbsp;Sérgio L. S. Salvador,&nbsp;Edilson Ervolino,&nbsp;Débora S. F. Sávio,&nbsp;Michel R. Messora,&nbsp;Flávia A. C. Furlaneto","doi":"10.1002/jper.70095","DOIUrl":"10.1002/jper.70095","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Prebiotic therapy is a promising approach for managing periodontitis due to its potential benefits in modulating the microbiome and the immune response. This study aimed to evaluate the effects of the prebiotic (PREB) polydextrose (PDX) on the development of experimental periodontitis (EP) in rats.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 44 male adult rats (&lt;i&gt;Rattus norvegicus, albinus&lt;/i&gt;, Wistar) were randomly allocated into groups (&lt;i&gt;n&lt;/i&gt; = 11) C (control), PREB, EP, and EP/PREB. The PREB and EP/PREB groups received 2 g of PDX/day in the drinking water for 44 days. The EP and EP/PREB groups received cotton ligatures around mandibular first molars (M1) for 14 days. Microtomographic, histopathological, and immunohistochemical analyses of periodontal and intestinal tissues were performed. Data were analyzed statistically (&lt;i&gt;p&lt;/i&gt; &lt; 0.05).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The EP/PREB group showed less alveolar bone destruction than the EP group. The EP/PREB group exhibited higher expressions of IL-10 and a lower number of TRAP (tartrate-resistant acid phosphatase)-positive cells than the EP group in periodontal tissues. The EP/PREB group had increased villus heights in the duodenum and ileum, increased crypt depths in the duodenum, and higher expressions of occludin in all intestinal portions, claudin-1 in the jejunum, IL-10 in the duodenum, and lower expressions of IL-1β in the jejunum compared with the EP group.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Polydextrose exerted a protective effect against alveolar bone resorption and favorably modulated both local and systemic immune-inflammatory response in rats with experimental periodontitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Prebiotic therapy has emerged as a promising approach for treating periodontitis, an immunoinflammatory disease associated with a dysbiotic biofilm that leads to the loss of the supporting structures of the teeth. This is because prebiotics can positively influence the balance of bacteria in the body and the immune system's response. However, current understanding of its potential effects and mechanisms of action remains limited in periodontal therapy. The effects of the prebiotic polydextrose (PDX) on periodontal tissues remain unknown. The results of the present study show that the prebiotic PDX can minimize alveolar bone loss and improve bone microarchitecture thro","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1529-1542"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of leukocyte-platelet-rich fibrin in periodontal surgery on clinical parameters and patient-related outcome measures: A randomized, controlled, clinical study.","authors":"Jackson S Sides,Archontia Palaiologou,Brian L Mealey,Stephan J Haney,Kerri Font,Charles A Powell","doi":"10.1002/jper.70166","DOIUrl":"https://doi.org/10.1002/jper.70166","url":null,"abstract":"BACKGROUNDThis prospective study aimed to assess the clinical outcomes and patient-related outcome measures (PROMs) of open flap debridement (OFD) alone versus open flap debridement with leukocyte-platelet-rich fibrin (L-PRF).METHODSTwenty-one patients were enrolled into a split-mouth randomized clinical trial. One side of the arch underwent OFD; the contralateral side of the same arch underwent the same OFD procedure with L-PRF placed across the alveolar bone and root surfaces underneath the buccal and lingual/palatal flap. Clinical parameters for probing depth (PD) and relative gingival recession (RGR) were recorded at six sites per tooth using a thermoplastic stent at baseline (immediately before surgery), 3 months, and 6 months. Bleeding on probing (BOP) and plaque scores were recorded at six sites per tooth throughout the study duration.RESULTSThe greatest reductions in PD were observed for sites ≥ 7 mm. Mean PD in the control group decreased from 7.38 mm at baseline to 3.15 mm at 3 months, with a subsequent increase to 4.00 mm at 6 months. In contrast, the test group demonstrated a sustained reduction from 7.75 mm at baseline to 3.25 mm at 3 months and 3.19 mm at 6 months. In moderate sites (4-6 mm), both groups demonstrated substantial PD reduction. Moderate subgroup mean PD decreased from 4.62 mm to 3.09 mm in the control group and from 4.76 mm to 3.19 mm in the test group at the 6-month timepoint. Relative recession and relative attachment level revealed no significant differences between the groups across all PDs. PROMs data showed that, although test group patients reported more swelling and pain early after surgery, they used less analgesics than the control group.CONCLUSIONSBased on the findings from this randomized clinical study, L-PRF was found to have improved, sustained PD reduction in deep periodontal pockets compared to OFD alone. L-PRF was not found to have a significant impact on PROMs or soft tissue healing compared to OFD alone.CLINICALTRIALSGOV IDENTIFIERNCT06296498 PLAIN LANGUAGE SUMMARY: In this split mouth, same arch clinical study, 21 patients were randomized into two study groups: open flap debridement (OFD) and OFD plus leukocyte-platelet-rich fibrin (L-PRF). Clinical parameters were recorded at baseline, 3 months, and 6 months after intervention, while healing and patient-reported outcome measures (PROMs) were evaluated 2 and 4 weeks after surgery. In sites ≥ 7 mm baseline PD, OFD plus L-PRF was associated with greater probing depth (PD) reduction and attachment level (AL) gain than control OFD alone, with similar gingival recession in both groups. Overall test group PD decrease was 4.44 mm, resulting in 1.05 mm more PD decrease in test sites than control. L-PRF effect was sustained with PD values in test sites reduced to 3.25 mm and 3.19 mm at 3 and 6 months, respectively (from 7.75 mm at baseline). The addition of L-PRF did not provide benefits in PROMs and soft tissue healing compared to sites treated with OFD a","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"39 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148428865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}