Journal of periodontology最新文献

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Leukemia inhibitory factor protects against experimental periodontitis through immuno-modulations of both macrophages and periodontal ligament fibroblasts. 白血病抑制因子通过对巨噬细胞和牙周韧带成纤维细胞进行免疫调节,防止实验性牙周炎的发生。
IF 4.3 2区 医学
Journal of periodontology Pub Date : 2024-03-15 DOI: 10.1002/JPER.23-0607
Yanjing Ou, Le Fan, Xiaoqi Wang, Haibin Xia, Mengwen Cheng, Jing Huang, Youde Liang, Yining Wang, Yi Zhou
{"title":"Leukemia inhibitory factor protects against experimental periodontitis through immuno-modulations of both macrophages and periodontal ligament fibroblasts.","authors":"Yanjing Ou, Le Fan, Xiaoqi Wang, Haibin Xia, Mengwen Cheng, Jing Huang, Youde Liang, Yining Wang, Yi Zhou","doi":"10.1002/JPER.23-0607","DOIUrl":"https://doi.org/10.1002/JPER.23-0607","url":null,"abstract":"<p><strong>Background: </strong>To explore the role of leukemia inhibitory factor (LIF) in periodontitis via in vivo and in vitro experiments.</p><p><strong>Methods: </strong>The second upper molar of LIF knockout mice and their wild-type littermates were ligated for 8 days. Micro-computed tomography (micro-CT), histological analysis, and quantitative real-time polymerase chain reaction (qRT-PCR) were performed. The expression levels of proinflammatory cytokines were examined in mouse bone marrow derived macrophages and human periodontal ligament fibroblasts (HPDLFs) after lipopolysaccharide (LPS) treatment.</p><p><strong>Results: </strong>LIF deficiency promoted alveolar bone loss, inflammatory cells infiltration, osteoclasts formation and collagen fiber degradation in ligature-induced mouse, along with higher expressions of proinflammatory cytokines, including interleukin-6 (IL6), IL-1β (IL1B), tumor necrosis factor-α (TNFA), matrix metalloproteinase 13 (MMP13), and RANKL/OPG ratio. Additionally, LIF deletion led to higher expression levels of these proinflammatory cytokines in mouse bone marrow-derived macrophages from both femur and alveolar bone and HPDLFs when treated with LPS. Administration of recombined LIF attenuated TNFA, IL1B, and RANKL/OPG ratio in HPDLFs.</p><p><strong>Conclusions: </strong>These findings indicate that LIF deficiency promotes the progress of periodontitis via modulating immuno-inflammatory responses of macrophages and periodontal ligament fibroblasts, and the application of LIF may be an adjunctive treatment for periodontitis to resolute inflammation.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of microbiome in primary and permanent dentition in grade C periodontitis in young individuals 评估 C 级牙周炎青少年基牙和恒牙中的微生物群。
IF 4.2 2区 医学
Journal of periodontology Pub Date : 2024-03-13 DOI: 10.1002/JPER.23-0504
Sungeun Stephanie Koo, Jussara G. Fernandes, Lu Li, Hong Huang, Ikramuddin Aukhil, Peter Harrison, Patricia I. Diaz, Luciana M. Shaddox
{"title":"Evaluation of microbiome in primary and permanent dentition in grade C periodontitis in young individuals","authors":"Sungeun Stephanie Koo,&nbsp;Jussara G. Fernandes,&nbsp;Lu Li,&nbsp;Hong Huang,&nbsp;Ikramuddin Aukhil,&nbsp;Peter Harrison,&nbsp;Patricia I. Diaz,&nbsp;Luciana M. Shaddox","doi":"10.1002/JPER.23-0504","DOIUrl":"10.1002/JPER.23-0504","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of the present study was to evaluate the subgingival microbiome in patients with grade C molar-incisor pattern periodontitis (C-MIP) affecting the primary or permanent dentitions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>DNA was isolated from subgingival biofilm samples from diseased and healthy sites from 45 C-MIP patients and subjected to phylogenetic microarray analysis. C-MIP sites were compared between children affected in the primary to those affected in the permanent dentitions. Within-subject differences between C-MIP-affected sites and dentition-matched healthy sites were also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>C-MIP sites of subjects affected in the primary dentition showed partially overlapping but distinct microbial communities from C-MIP permanent dentition sites (<i>p</i> &lt; 0.05). Differences were due to increased levels in primary C-MIP sites of certain species of the genera <i>Capnocytophaga and Leptotrichia</i>, while C-MIP permanent dentition sites showed higher prevalence of <i>Filifactor alocis</i>. <i>Aggregatibacter actinomycetemcomitans</i> (<i>Aa</i>) was among species seen in high prevalence and levels in both primary and permanent C-MIP sites. Moreover, both permanent and primary C-MIP sites showed distinct microbial communities when compared to dentition-matched healthy sites in the same subject (<i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Primary and permanent teeth with C-MIP showed a dysbiotic microbiome, with children affected in the primary dentition showing a distinct profile from those affected in the permanent dentition. However, <i>Aa</i> was enriched in both primary and permanent diseased sites, confirming that this microorganism is implicated in C-MIP in both dentitions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140110486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the effect of Er,Cr:YSGG laser application on peri-implant crevicular fluid receptor activator of nuclear factor-kappa B ligand and osteoprotegerin levels in the non-surgical treatment of peri-implantitis: A randomized clinical trial 评估 Er,Cr:YSGG激光在非手术治疗种植体周围炎中对种植体周围缝隙液中核因子卡巴B配体受体激活剂和骨保护素水平的影响:随机临床试验。
IF 4.2 2区 医学
Journal of periodontology Pub Date : 2024-02-20 DOI: 10.1002/JPER.23-0540
Nazli Zeynep Alpaslan, Dicle Altindal, Damla Akbal, Ahmet Cemil Talmac, Serap Keskin Tunc, Abdullah Seckin Ertugrul
{"title":"Evaluation of the effect of Er,Cr:YSGG laser application on peri-implant crevicular fluid receptor activator of nuclear factor-kappa B ligand and osteoprotegerin levels in the non-surgical treatment of peri-implantitis: A randomized clinical trial","authors":"Nazli Zeynep Alpaslan,&nbsp;Dicle Altindal,&nbsp;Damla Akbal,&nbsp;Ahmet Cemil Talmac,&nbsp;Serap Keskin Tunc,&nbsp;Abdullah Seckin Ertugrul","doi":"10.1002/JPER.23-0540","DOIUrl":"10.1002/JPER.23-0540","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aimed to investigate the effect of erbium, chromium doped:yttrium,scandium,gallium,garnet (Er,Cr:YSGG) laser application combined with non-surgical mechanical debridement (MD) on clinical parameters and peri-implant crevicular fluid receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) levels in the treatment of peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 49 patients who underwent non-surgical treatment of peri-implantitis were randomly divided into two groups. The control group (<i>n</i> = 26) received MD alone, while the laser group (<i>n</i> = 23) received MD+Er,Cr:YSGG. The clinical parameters (bleeding on probing [BoP], gingival index [GI], plaque index [PI], probing depth [PD]), marginal bone loss (MBL), and biochemical parameters (RANKL and OPG) were measured at baseline (T0) and 6 months after treatment (T1).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was a statistically significant decrease in all the clinical parameters in both groups at T1 compared to T0 (<i>p</i> &lt; 0.05). The BoP, PD, MBL, and RANKL reductions were significantly higher in the laser group than in the control group (<i>p</i> = 0.046, <i>p</i> = 0.014, <i>p</i> = 0.047, <i>p</i> = 0.045, respectively). The OPG levels significantly increased at T1 in the laser group (<i>p</i> = 0.01). The OPG/RANKL ratio increased significantly in both groups at T1, which favored the laser group (<i>p</i> = 0.034).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although both treatment methods were influential in treating peri-implantitis, the laser group (MD+Er,Cr:YSGG) yielded more favorable results by reducing clinical inflammation and improving biochemical parameters. Based on these findings, Er,Cr:YSGG laser may be a beneficial adjunctive treatment in this patient group.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical evaluation of a novel protocol for supportive periodontal care: A randomized controlled clinical trial. 牙周支持性护理新方案的临床评估:随机对照临床试验。
IF 4.3 2区 医学
Journal of periodontology Pub Date : 2024-01-31 DOI: 10.1002/JPER.23-0527
Alexandra Stähli, Jvana Ferrari, Anna Sophia Schatzmann, Lucienne Dominique Weigel, Andrea Roccuzzo, Jean-Claude Imber, Ho-Yan Duong, Sigrun Eick, Niklaus P Lang, Giovanni E Salvi, Anton Sculean
{"title":"Clinical evaluation of a novel protocol for supportive periodontal care: A randomized controlled clinical trial.","authors":"Alexandra Stähli, Jvana Ferrari, Anna Sophia Schatzmann, Lucienne Dominique Weigel, Andrea Roccuzzo, Jean-Claude Imber, Ho-Yan Duong, Sigrun Eick, Niklaus P Lang, Giovanni E Salvi, Anton Sculean","doi":"10.1002/JPER.23-0527","DOIUrl":"https://doi.org/10.1002/JPER.23-0527","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to compare the clinical efficacy and the patient perception of subgingival debridement with either guided biofilm management (GBM) or conventional scaling and root planing (SRP) during supportive periodontal care (SPC).</p><p><strong>Methods: </strong>Forty-one patients in SPC were randomly assigned to either treatment with GBM or SRP every 6 months. The primary outcome was the percentage of bleeding on probing (BoP) at 1 year. Moreover, pocket probing depths (PPD), recession, and furcation involvements were also measured. Full-mouth and specific site analyzes were performed at baseline, 6 and 12 months of SPC. Patient comfort was evaluated using a visual analogue scale (VAS) at 12 months.</p><p><strong>Results: </strong>At 1 year, mean BoP percentage decreased from 12.2% to 9.0% (p = 0.191) and from 14.7% to 7.9% (p = 0.004) for the GBM and SRP groups, respectively. Furcation involved multirooted teeth but no through-and-through lesions were significantly fewer in the GBM than in the SRP group after 12 months (p = 0.015). The remaining parameters showed slight improvement in both groups without any statistically significant differences between the two groups after 1 year. Pain evaluation as patient reported outcome measures (pain evaluation) was in favor (p = 0.347) of the SRP group, while overall satisfaction was similar for both groups. Treatment time was not statistically significantly different between the two groups (p = 0.188).</p><p><strong>Conclusion: </strong>In well-maintained SPC patients, SRP protocols resulted in significant clinical improvements in terms of BoP; however, for the other clinical improvements, similar efficacy for both GBM and SRP was observed.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence in dental education: ChatGPT's performance on the periodontic in-service examination 人工智能在牙科教育中的应用:ChatGPT 在牙周病学在职考试中的表现。
IF 4.2 2区 医学
Journal of periodontology Pub Date : 2024-01-10 DOI: 10.1002/JPER.23-0514
Arman Danesh, Hirad Pazouki, Farzad Danesh, Arsalan Danesh, Saynur Vardar-Sengul
{"title":"Artificial intelligence in dental education: ChatGPT's performance on the periodontic in-service examination","authors":"Arman Danesh,&nbsp;Hirad Pazouki,&nbsp;Farzad Danesh,&nbsp;Arsalan Danesh,&nbsp;Saynur Vardar-Sengul","doi":"10.1002/JPER.23-0514","DOIUrl":"10.1002/JPER.23-0514","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>ChatGPT's (Chat Generative Pre-Trained Transformer) remarkable capacity to generate human-like output makes it an appealing learning tool for healthcare students worldwide. Nevertheless, the chatbot's responses may be subject to inaccuracies, putting forth an intense risk of misinformation. ChatGPT's capabilities should be examined in every corner of healthcare education, including dentistry and its specialties, to understand the potential of misinformation associated with the chatbot's use as a learning tool. Our investigation aims to explore ChatGPT's foundation of knowledge in the field of periodontology by evaluating the chatbot's performance on questions obtained from an in-service examination administered by the American Academy of Periodontology (AAP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>ChatGPT3.5 and ChatGPT4 were evaluated on 311 multiple-choice questions obtained from the 2023 in-service examination administered by the AAP. The dataset of in-service examination questions was accessed through Nova Southeastern University's Department of Periodontology. Our study excluded questions containing an image as ChatGPT does not accept image inputs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ChatGPT3.5 and ChatGPT4 answered 57.9% and 73.6% of in-service questions correctly on the 2023 Periodontics In-Service Written Examination, respectively. A two-tailed <i>t</i> test was incorporated to compare independent sample means, and sample proportions were compared using a two-tailed χ<sup>2</sup> test. A <i>p</i> value below the threshold of 0.05 was deemed statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While ChatGPT4 showed a higher proficiency compared to ChatGPT3.5, both chatbot models leave considerable room for misinformation with their responses relating to periodontology. The findings of the study encourage residents to scrutinize the periodontic information generated by ChatGPT to account for the chatbot's current limitations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity of individual self-report oral health measures in assessing periodontitis for causal research applications 个人自我报告口腔健康措施在因果研究应用中评估牙周炎的有效性。
IF 4.2 2区 医学
Journal of periodontology Pub Date : 2024-01-10 DOI: 10.1002/JPER.23-0551
Julia C. Bond, Sharon M. Casey, Robert McDonough, Suzanne G. McLone, Mabeline Velez, Brenda Heaton
{"title":"Validity of individual self-report oral health measures in assessing periodontitis for causal research applications","authors":"Julia C. Bond,&nbsp;Sharon M. Casey,&nbsp;Robert McDonough,&nbsp;Suzanne G. McLone,&nbsp;Mabeline Velez,&nbsp;Brenda Heaton","doi":"10.1002/JPER.23-0551","DOIUrl":"10.1002/JPER.23-0551","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Self-reported measures of periodontitis developed for use in population surveillance are increasingly used in causal research. Numerous studies evaluate the validity of these measures against clinical parameters of periodontitis, yet few include validation parameters outside of multivariable models. Individual item validity is necessary to adequately inform use of these measures in causal research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used data from the National Health and Nutrition Examination Survey 2011-2014 in which dentate participants completed full-mouth periodontal examinations (<i>N</i> = 6966). We evaluated six self-report questionnaire items related to periodontal disease status against periodontitis case definitions developed by the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC-AAP). We estimated the sensitivity and specificity of individual items using severe and moderate-to-severe periodontitis classifications. We additionally combined items to evaluate the validity of joint measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sensitivity was highest when measures were evaluated against severe periodontitis. Self-rated oral health of fair/poor demonstrated the highest sensitivity for severe (0.60) and moderate-to-severe periodontitis (0.48). Specificity was highest when evaluated against moderate-to-severe periodontitis, with self-reported history of tooth mobility as the most specific measure (0.87 for severe disease; 0.92 for moderate-to-severe) followed by a history of bone loss (0.88 for severe; 0.91 for moderate-to-severe). Combining questions generally improved specificity at the expense of sensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings related to item-specific validity and the associated clinical profiles facilitate needed considerations for the use of self-reported measures of periodontitis in causal research. Additionally, item-specific validity can be used to inform assessments of misclassification bias within such investigations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk indicators for gingival recession in the esthetic zone: A cross-sectional clinical, tomographic, and ultrasonographic study 美容区牙龈退缩的风险指标:一项横断面临床、断层和超声波研究。
IF 4.3 2区 医学
Journal of periodontology Pub Date : 2024-01-09 DOI: 10.1002/JPER.23-0357
Kathleen Chloe Mascardo, Justin Tomack, Chia-Yu Chen, Leonardo Mancini, David M. Kim, Bernard Friedland, Shayan Barootchi, Lorenzo Tavelli
{"title":"Risk indicators for gingival recession in the esthetic zone: A cross-sectional clinical, tomographic, and ultrasonographic study","authors":"Kathleen Chloe Mascardo,&nbsp;Justin Tomack,&nbsp;Chia-Yu Chen,&nbsp;Leonardo Mancini,&nbsp;David M. Kim,&nbsp;Bernard Friedland,&nbsp;Shayan Barootchi,&nbsp;Lorenzo Tavelli","doi":"10.1002/JPER.23-0357","DOIUrl":"10.1002/JPER.23-0357","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To evaluate the risk indicators associated with midfacial gingival recessions (GR) in the natural dentition esthetic regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cone-beam computed tomography (CBCT) results of thirty-seven subjects presenting with 268 eligible teeth were included in the cross-sectional study. Clinical measurements included presence/absence of midfacial GR; the depth of the midfacial, mesial, and distal gingival recession; the recession type (RT); keratinized tissue width (KT); and attached gingiva width (AG). Questionnaires were utilized to capture patient-reported esthetics and dental hypersensitivity for each study tooth. Buccal bone dehiscence (cBBD) and buccal bone thickness (cBBT) were measured on the CBCT scans. High-frequency ultrasonography was performed to assess gingival thickness (GT) and buccal bone dehiscence (uBBD). Intraoral optical scanning was obtained to quantify the buccolingual position of each study site (3D profile analysis). Multilevel logistic regression analyses with generalized estimation equations were performed to assess the factors associated with the conditions of interest.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The presence of midfacial GR was significantly associated with the history of periodontal treatment for pocket reduction (OR 7.99, <i>p</i> = 0.006), KT (OR 0.62, <i>p</i> &lt; 0.001), cBBD (OR 2.30, <i>p</i> = 0.015), GT 1.5 mm from the gingival margin (OR 0.18, <i>p</i> = 0.04) and 3D profile 1 mm from the gingival margin (OR 1.04, <i>p</i> = 0.001). The depth of midfacial GR was significantly correlated to previous history of periodontal treatment (OR 0.96, <i>p</i> = 0.001), KT (OR −0.18, <i>p</i> &lt; 0.001), presence of bone fenestration (OR 0.24, <i>p</i> = 0.044), and cBBD (OR 0.43, <i>p</i> &lt; 0.001). The depth of midfacial GR was also the only factor associated with patient-reported esthetics (OR −3.38, <i>p</i> = 0.022), while KT (OR 0.77, <i>p</i> = 0.018) and AG (OR 0.82, <i>p</i> = 0.047) were significantly correlated with patient-reported dental hypersensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Several risk indicators of midfacial and interproximal GR in the esthetic region were identified. The use of imaging technologies allowed for detection of parameters associated with the conditions of interest, and, therefore, their incorporation in future clinical studies is advocated. Ultrasonography could be preferred over CBCT for a noninvasive assessment of periodontal phenotype.</p>\u0000 </section>\u0000","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periodontists and stem cell-based therapy for alveolar bone regeneration: A national survey 牙周病医生与干细胞牙槽骨再生疗法:全国调查。
IF 4.2 2区 医学
Journal of periodontology Pub Date : 2024-01-09 DOI: 10.1002/JPER.23-0506
Darnell Kaigler, Jonathan Misch, Abdusalam Alrmali, Marita R. Inglehart
{"title":"Periodontists and stem cell-based therapy for alveolar bone regeneration: A national survey","authors":"Darnell Kaigler,&nbsp;Jonathan Misch,&nbsp;Abdusalam Alrmali,&nbsp;Marita R. Inglehart","doi":"10.1002/JPER.23-0506","DOIUrl":"10.1002/JPER.23-0506","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Stem cell-based therapy for bone regeneration has received attention in medical settings but has not yet been used in clinical practice for treating alveolar bone defects. The objectives of this study were to explore whether periodontists had heard about this approach, and if so how, how interested they were to learn about it, which attitudes and behavioral intentions they had related to using stem cell-based grafting, and what they would like to know before using this approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Anonymous survey data were collected from 481 members of the American Academy of Periodontology (response rate: 19.41%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Responses showed 35.3% had heard about stem cell-based therapy, mostly from publications (9.6%) and meetings (8.3%); 76.1% wanted to learn about it through in-person continuing education (CE) courses, 68.6% in online CE courses, and 57.1% from manuals; 73% considered this approach promising; and 54.9% preferred it to traditional approaches. It was important to them that it would result in more bone volume (93%), better bone quality (90.4%), and accelerated healing (83.2%). Also, 60.1% considered it likely/very likely that they would adopt this approach, 54% that patients would prefer it, and 62.1% that it would benefit their practice. When asked what they would like to know about this approach, information about short- and long-term outcomes, cost, and logistical considerations were most frequently named.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings provide the basis to develop educational interventions for periodontists about this novel approach and inform future research activities aimed to translate this approach to clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of dietary inflammatory index on gingival health 饮食炎症指数对牙龈健康的影响。
IF 4.2 2区 医学
Journal of periodontology Pub Date : 2023-12-28 DOI: 10.1002/JPER.23-0292
Roberta Andrade Reis, Camila Schmidt Stolf, Helena Alves de Carvalho Sampaio, Bruna Yhang da Costa Silva, Tuğçe Özlü, Emre Batuhan Kenger, Manuela Maria Vianal Miguel, Mauro Pedrine Santamaria, Mabelle de Freitas Monteiro, Marcio Zaffalon Casati, Renato Corrêa Viana Casarin
{"title":"Impact of dietary inflammatory index on gingival health","authors":"Roberta Andrade Reis,&nbsp;Camila Schmidt Stolf,&nbsp;Helena Alves de Carvalho Sampaio,&nbsp;Bruna Yhang da Costa Silva,&nbsp;Tuğçe Özlü,&nbsp;Emre Batuhan Kenger,&nbsp;Manuela Maria Vianal Miguel,&nbsp;Mauro Pedrine Santamaria,&nbsp;Mabelle de Freitas Monteiro,&nbsp;Marcio Zaffalon Casati,&nbsp;Renato Corrêa Viana Casarin","doi":"10.1002/JPER.23-0292","DOIUrl":"10.1002/JPER.23-0292","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Periodontal disease is a biofilm-dependent chronic inflammatory condition triggered by a host response. Several factors impact systemic inflammation and could lead to changes in disease pathogenesis. Recently, studies have assessed the influence of nutritional patterns on the development of periodontitis. In the present cross-sectional study, we evaluated the dietary inflammatory profile on periodontal conditions, focusing on clinical, subgingival microbial, and cytokine assessment of individuals with periodontal health or gingivitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One hundred patients with periodontal health or gingivitis were included. Plaque index (PI), Bleeding on probing (BoP), the probing depth (PD), and the clinical attachment level (CAL) for each patient were assessed. Nutritional data and the Dietary Inflammatory Index (DII) were recorded by two 24-h food recalls on non-consecutive days. Biofilm and gingival crevicular fluid (GCF) to assess the microbiome profile and inflammatory biomarkers were collected. Multiple regressions focused on the DII, age, and sex as predictors of periodontal conditions were done.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Age and moderate DII scores increased the risk of gingivitis by 1.64 and 3.94 times, respectively. Males with an elevated DII score had 27.15 times higher odds of being diagnosed with gingivitis and BoP (<i>β</i> = 6.54; <i>p</i> = 0.03). Elderly patients with a moderate or high DII score were less prone to gingivitis and increased BoP (<i>p</i> &lt; 0.04) compared with younger subjects. Considering the DII, there were no differences in microbial alpha and beta diversity; however, distinct species abundance and a higher concentration of monocyte-chemoattractant protein-1 and interleukin 33 were seen in patients with a higher DII.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A pro-inflammatory diet significantly contributes to periodontal inflammation, modulating inflammatory biomarkers and affecting the subgingival microbial community in healthy individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0292","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of active oxygen-releasing gel and photodynamic therapy in the treatment of residual periodontal pockets in type 2 diabetic patients: A randomized controlled clinical study 活性氧释放凝胶与光动力疗法在治疗 2 型糖尿病患者残余牙周袋中的结合:随机对照临床研究。
IF 4.3 2区 医学
Journal of periodontology Pub Date : 2023-12-19 DOI: 10.1002/JPER.23-0125
Marina M. Cláudio, Valdir G. Garcia, Rubens M. Freitas, João Victor S. Rodrigues, Mark Wainwright, Renato C. V. Casarin, Cristiane Duque, Leticia H. Theodoro
{"title":"Association of active oxygen-releasing gel and photodynamic therapy in the treatment of residual periodontal pockets in type 2 diabetic patients: A randomized controlled clinical study","authors":"Marina M. Cláudio,&nbsp;Valdir G. Garcia,&nbsp;Rubens M. Freitas,&nbsp;João Victor S. Rodrigues,&nbsp;Mark Wainwright,&nbsp;Renato C. V. Casarin,&nbsp;Cristiane Duque,&nbsp;Leticia H. Theodoro","doi":"10.1002/JPER.23-0125","DOIUrl":"10.1002/JPER.23-0125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the effect of active oxygen-releasing gel as an adjuvant, with and without antimicrobial photodynamic therapy (aPDT), in the treatment of residual pockets in periodontal patients with type 2 diabetes mellitus (DM2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with residual pockets with probing depth (PD) ≥4 mm and bleeding on probing (BOP) were divided into the following groups: SI (<i>n</i> = 17)—subgingival instrumentation in a single session; BM (<i>n</i> = 17)—SI followed by local application of active oxygen-releasing gel inside the periodontal pocket for 3 min; BM + aPDT (<i>n</i> = 17)—SI followed by application of BM for 3 min and pocket irrigation with methylene blue, and 660-nm diode laser irradiation at 100 mW for 50 s. The periodontal clinical parameters, serum levels of glycated hemoglobin, and immunological analysis of crevicular fluid were evaluated. All data were submitted to statistical analysis (α = 5%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant reduction in BOP was verified at 90 and 180 days in the BM + aPDT group. The percentage of sites with PD ≥ 4 mm was significantly reduced at 90 days in BM + aPDT and BM, whereas after 180 days only BM showed a significant reduction. In the BM + aPDT group, there was a significant reduction in tumor necrosis factor α levels at 90 days. There were no differences between the treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The use of adjuvant active oxygen-releasing gel, with or without aPDT, resulted in the same clinical benefits as SI in the treatment of residual pockets in poorly controlled DM2 patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138805314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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