Journal of periodontology最新文献

{"title":"A retrospective cohort study comparing periodontal regeneration using fibroblast growth factor-2 versus autologous bone graft","authors":"Toshiki Matsumoto, Shin Nakamura, Yuki Ito-Shinoda, Mai Sakamoto, Takayuki Ishii, Yasuki Nonomura, Hidetaka Ideguchi, Keisuke Okubo, Kazu Takeuchi-Hatanaka, Kazuhiro Omori, Tadashi Yamamoto, Shogo Takashiba","doi":"10.1002/jper.70060","DOIUrl":"10.1002/jper.70060","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fibroblast growth factor-2 (FGF-2) is a novel agent utilized in periodontal regeneration therapy. However, its clinical efficacy compared with autologous bone graft (ABG), a long-established treatment, remains unclear. This study aimed to compare the clinical outcomes of FGF-2 and ABG and to assess the impact of patient background factors on outcomes when using FGF-2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We collected the subjects from January 2013 to September 2023. Clinical outcomes included the vertical bone defect improvement rate (VBDIR) and the probing pocket depth improvement (PPDI). Clinical outcomes between the two groups were compared using analysis of covariance (ANCOVA), adjusting for age, sex, smoking history, and hypertension. Additionally, a multilevel linear analysis was performed to assess factors influencing outcomes in FGF-2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 180 sites from 141 patients (FGF-2: 150 sites; ABG: 30 sites) were evaluated. Both VBDIR and PPDI significantly improved postoperatively in both groups. There were no significant differences in clinical outcomes between FGF-2 and ABG. In FGF-2, smoking history was positively associated, while the preoperative bone defect angle (BDA) was negatively associated with clinical outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>FGF-2 might exhibit clinical outcomes comparable to those of ABG, suggesting it is a clinically viable alternative for vertical bone defects. When using FGF-2, patient-specific factors such as smoking history and preoperative BDA should be considered carefully.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> The name in the trial registry</h3>\u0000 \u0000 <p>A survey of clinical practice and evaluation of treatment outcomes of periodontal regenerative therapy using REGROTH at Okayama University Hospital</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>This retrospective study compared the clinical outcomes of fibroblast growth factor-2 (FGF-2), a novel therapeutic agent, with autologous bone graft (ABG), a long-established treatment. A total of 180 sites from 141 patients (150 FGF-2 sites, 30 ABG sites) were evaluated based on the vertical bone defect improvement rate (VBDIR) and the probing pocket depth improvement (PPDI). Using analysis of covariance (ANCOVA), adjusted for patient background fa","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1431-1441"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveying immune and inflammatory alterations in periodontitis among individuals with Down syndrome: A preliminary cross-sectional study","authors":"Leticia Helena Theodoro, João Victor Soares Rodrigues, Marta A. A. Nuernberg, Pedro Henrique Petrilli, Mabelle de Freitas Monteiro, Valdir Gouveia Garcia, Rafael Scaf de Molon, Renato Correa Viana Casarin","doi":"10.1002/jper.70087","DOIUrl":"10.1002/jper.70087","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals with Down syndrome (DS) are particularly vulnerable to early-onset and rapidly progressing periodontitis, yet the local immune-inflammatory alterations that contribute to this susceptibility are not fully understood. This study aimed to characterize cytokine profiles in gingival crevicular fluid (GCF) from individuals with DS and periodontitis and to compare them with those of periodontitis patients without DS and periodontally healthy controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty-five participants were enrolled and divided equally into three groups (<i>n</i> = 15 each): DS with periodontitis (DSP), periodontitis without DS (P), and systemically and periodontally healthy controls (C). GCF samples were collected from two interproximal sites per participant and analyzed for IL-1β, IL-4, IL-6, IL-10, TNF-α, and IFN-γ using multiplex immunoassays. Standard periodontal parameters, including probing depth, attachment level, bleeding on probing, and plaque index, were also recorded. Non-parametric comparisons and multivariate approaches, including principal component analysis and hierarchical clustering, were employed to explore cytokine distribution patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Individuals with DS and periodontitis exhibited a heterogeneous but predominantly pro-inflammatory cytokine profile, characterized by elevated IL-1β, IL-6, TNF-α, and higher Th1/Th2 and IL-1β/IL-10 ratios. In contrast, the P group demonstrated a Th2-skewed response with higher levels of IL-4, IL-10, and IFN-γ, suggestive of compensatory immune regulation. Healthy controls consistently displayed the lowest cytokine concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This preliminary study identifies a distinct pro-inflammatory cytokine profile in Down syndrome-associated periodontitis, characterized by heightened IL-1β responses and a Th1-skewed immune pattern. While limited by sample size and the absence of a DS-healthy control group, these findings provide initial mechanistic insights into the accelerated periodontal breakdown observed in DS and lay the groundwork for future, larger-scale investigations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>People with Down syndrome (DS) often develop gum disease, called periodontitis, much earlier and more severely than others. This condition damages the tissues and bone that support the teeth and can lead to tooth ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1467-1480"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of periodontal treatment on adipokines in patients with type 2 diabetes mellitus: A systematic review","authors":"Natalia Christaki, Dimitra Baladina, Panagiotis A. Koromantzos, Yiorgos A. Bobetsis","doi":"10.1002/jper.70121","DOIUrl":"10.1002/jper.70121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Periodontal disease (PD) is associated with type 2 diabetes mellitus (T2DM), while periodontal treatment (PT) improves glycemic control in T2DM patients. Leptin and adiponectin belong to the adipokines family and have almost antagonistic functions in inflammatory processes and insulin sensitivity modulation. Hence, these hormones have been linked with both PD severity and glycemic control. This systematic review aims to assess the effect of PT on serum levels of leptin and adiponectin in patients with T2DM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed, Cochrane Library, and Google Scholar databases and ClinicalTrials.gov website were searched up to January 5th, 2025. Randomized and non-randomized controlled clinical trials (RCTs and CCTs) including patients with T2DM and PD who underwent PT and evaluated serum levels of leptin and adiponectin were included. Assessments of risk of bias and of certainty of evidence were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven trials were eligible for qualitative synthesis. A statistically significant increase in serum adiponectin levels was observed across most studies, while no such consistency was observed for leptin. The overall level of certainty of evidence was judged low in the RCTs and very low in the CCTs. Meta-analysis could not be performed due to significant methodological heterogeneity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Preliminary findings suggest a potential increase in adiponectin levels in T2DM patients, with possible implications for glycemic control. However, these results should be interpreted with caution due to the small number of studies and important methodological limitations. Well-designed studies with larger sample sizes and adequate adjustment for confounders are necessary to verify this observation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>People with type 2 diabetes often also have periodontitis, an inflammatory gum disease, which may affect their overall health. The aim of this study was to investigate whether treating periodontitis could help improve certain substances in the blood—called adiponectin and leptin—that are linked to blood sugar control and inflammation. Several studies that tested this in people with both diabetes and periodontitis were included and most of them showed that, after periodontal treatment, levels of adiponectin (which helps reduce inflammation and improv","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1491-1502"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147708483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porphyromonas gingivalis and Scardovia wiggsiae promote neutrophil-induced lung epithelial cell apoptosis and emphysema","authors":"Hsin-Han Hou, Yen-Fu Chen, Yi-Wen Chen, Chung-Wei Wang, Shih-Jung Cheng, Chun-Pin Lin, Hao-Chien Wang, Yen-Ling Chu, Chong-Jen Yu","doi":"10.1002/jper.70091","DOIUrl":"10.1002/jper.70091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic obstructive pulmonary disease (COPD) is a chronic lung disease with bronchitis and pulmonary emphysema phenotypes, with high morbidity and mortality. COPD is predicted to be the third leading cause of death by 2030. Periodontitis results from oral microbe dysbiosis, such as enrichment of periodontitis pathogens (e.g., <i>Porphyromonas gingivalis</i>), which could disseminate to the lung via the blood stream or aspiration. Periodontitis pathogens are suggested to contribute to chronic inflammation and mucin secretion in the lung. Accordingly, periodontitis pathogens are associated with the pathogenesis and progression of COPD. However, clinical observation of a correlation between COPD and periodontitis is limited and the involved mechanism is not fully understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used a mouse model with ligature-induced periodontitis and porcine pancreatic elastase (PPE)-induced pulmonary emphysema to evaluate the roles of <i>P. gingivalis</i> and <i>Scardovia wiggsiae</i> in COPD progression. We analyzed proinflammatory cytokines, immune cells, apoptosis, and the extent of COPD progression using a multiplex assay/enzyme-linked immunosorbent assay, Hemacolor kit, terminal deoxynucleotidyl transferase nick-end labeling assay, and the mean linear intercept and lung function, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results suggest that both oral bacterial species contributed to the periodontitis phenotype, promoted PPE-induced proinflammatory cytokines in serum and bronchoalveolar lavage, and facilitated neutrophil infiltration in the lung. The abundance of neutrophils increased neutrophil elastase (NE) and downstream placenta growth factor (PGF) in the lung and led to alveolar epithelial cell apoptosis, pulmonary emphysema and lung function decline in the PPE-treated mice. All pathological phenotype were attenuated by Ly6G antibody-mediated neutrophil depletion in mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We demonstrated a potential mechanism for periodontal-associated progression to COPD via the neutrophil-NE-PGF pathway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>We demonstrated that the oral bacteria <i>Porphyromonas gingivalis</i> and <i>Scardovia wiggsiae</i> exacerbate ligature-induced inflammation and increase proinflammatory cytokines in local gingival crevicular fluid, systemic serum, and distal bronchoalveolar lavage, and are associated with more neutrophil infiltration in the lung. The in vivo experiment ind","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1516-1528"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type I interferon-induced CD169+ macrophages play a protective role in periodontitis","authors":"Jiawei Lu, Zehui Xiong, Xiao Wu, Yanan Yang, Jinyi Zhang, Lijun Luo","doi":"10.1002/jper.70102","DOIUrl":"10.1002/jper.70102","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aims to investigate the transcriptional characteristics and differentiation microenvironment of the CD169<sup>+</sup> macrophages in periodontal tissues, and to explore their impact on periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Single-cell RNA sequencing landscape of periodontal tissues from healthy controls (<i>n</i> = 8) and periodontitis patients (<i>n</i> = 10) were constructed. Immunohistochemical staining was used to detect the percentage of CD169<sup>+</sup> macrophages in periodontitis tissues of different severity to explore the potential links between them and periodontitis. Anti-IFNAR1 antibodies were used to block the IFNAR1 receptor in mice to validate the role of type I interferon signaling in CD169<sup>+</sup> macrophage differentiation and its impact on the progression of periodontitis. <i>SCENIC</i> analysis, immunohistochemical staining, immunofluorescence staining, flow cytometry, and in vitro experiments were used to identify the surface markers, differentiation microenvironment, and regulatory mechanisms of CD169<sup>+</sup> macrophages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The phenotypes of CD169<sup>+</sup> macrophages are characterized by CD169<sup>+</sup>, MERTK<sup>+</sup>, CX3CR1<sup>−</sup>, and CCR2<sup>−</sup>. The CD169<sup>+</sup> macrophages could maintain immune homeostasis by producing CCL18 and IL10. The percentage of CD169<sup>+</sup> cells in periodontal tissues was found to be negatively correlated with the severity of periodontitis. Type I interferons produced by gingival fibroblasts and keratinocytes are essential for the differentiation of CD169<sup>+</sup> macrophages, which in turn orchestrate immunomodulation and tissue homeostasis restoration during the recovery phase of periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings indicate that type I interferons produced by fibroblasts in periodontal tissues induce monocytes to differentiate into macrophages with a CD169<sup>+</sup>MERTK<sup>+</sup> phenotype. These cells play a role in negative immune regulation and may provide a positive contribution to the recovery of periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>Periodontitis is one of the major diseases that threaten human health. CD169<sup>+</sup> macrophages may play a key role in immune homeostasis by producing IL10 and CCL18. The type I interferon-IRF7 axis may induce the differentiation of macrophages into CD169<sup>+</sup> macrophages, which in turn orchestrates immunomod","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1543-1558"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterial used to counteract ridge reduction following the removal of adjacent teeth: A randomized controlled multicenter study","authors":"Denis Cecchinato, Enrico Corrà, Eriberto Bressan, Marika Gervasi, Marco Menoncin, Enrico Savio, Marco Toia","doi":"10.1002/jper.70084","DOIUrl":"10.1002/jper.70084","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alveolar ridge resorption (ARP) is a well-recognized consequence of tooth extraction, and multiple adjacent extractions may lead to greater ridge reduction than single-tooth extractions. This multicenter randomized controlled trial aimed to assess ridge remodeling after removing 2 adjacent teeth and whether socket grafting with deproteinized bovine bone mineral with collagen (DBBM-C) plus a collagen membrane could counteract the ridge reduction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty-two patients requiring 2 adjacent tooth extractions were randomly assigned to either Test (DBBM-C graft + collagen membrane) or Control (natural healing). Impressions were taken immediately after extraction and at 6 months, and models were analyzed to measure changes in horizontal ridge width (bucco-lingual at 3 mm below the crest) and vertical ridge height (buccal and lingual).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 6 months, grafted sites had significantly less ridge reduction than controls. Horizontal ridge width reduction averaged 57.7% in Control versus 23.0% in Test (<i>p</i> < 0.001). Vertical height loss was also greater in controls (buccal 3.0 mm vs. 1.5 mm; lingual 2.2 mm vs. 1.3 mm; <i>p</i> < 0.001). Both mesial and distal sockets benefited similarly from grafting, with comparable preservation at each site.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Filling adjacent extraction sockets with DBBM-C and covering with a collagen membrane significantly reduced horizontal and vertical alveolar ridge resorption compared to unassisted healing. This approach effectively preserves bone volume after multiple tooth extractions, which may facilitate later implant placement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>When 2 neighboring teeth are removed, the area tends to shrink in width and height as it heals. This bone loss can make it more difficult to place dental implants later. In this study, we tested a method to help maintain the bone after removing 2 adjacent teeth. In the Test group, the empty tooth sockets were filled with a bone graft material (deproteinized bovine bone mineral and collagen) and covered with a collagen membrane. In the Control group, the sites were left to heal physiologically. A total of 42 patients participated, each needing 2 side-by-side teeth removed. After 6 months of healing, we compared models of the patients from right after the extractions t","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1481-1490"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulators, associated or not with systemic antibiotics, to treat periodontitis: A 1-year multicenter, placebo-controlled, double-blind, randomized clinical trial","authors":"Nidia C. Castro dos Santos, Rafael N. de Brito Silva, Fernanda S. Colombo, Ingrid Oliveira-Cardoso, Lina J. Súarez, Rodrigo Martins, Luciene C. de Figueiredo, Heitor Marques Honório, Ademir Melo Leite Filho, Flavia A. C. Furlaneto, Michel R. Messora, Monique Furukawa, José Roberto Cortelli, Emanuel Silva Rovai, Magda Feres","doi":"10.1002/jper.70081","DOIUrl":"10.1002/jper.70081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Immunomodulatory agents such as omega-3 (ω-3) and low-dose aspirin (ASA) have been proposed as effective adjuncts in the treatment of periodontitis. However, they still lack long-term studies and head-to-head evaluation with metronidazole (MTZ) and amoxicillin (AMX), the adjunct protocol with the strongest scientific evidence of clinical benefit. This study aimed to evaluate the clinical effects of (ω)-3 and ASA, alone or combined with MTZ + AMX, to treat periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adults with stage III/IV periodontitis were randomly allocated to receive: (i) subgingival instrumentation (SI) and placebo; (ii) SI with adjunctive MTZ (400 mg) + AMX (500 mg) three times/day for 14 days (ATB); (iii) SI with adjunctive ω-3 (3 g) + ASA (100 mg/day) for 6 months (IM); and (iv) SI with adjunctive ATB and IM (ATB + IM). The patients were followed for 1 year post-therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>109 patients were included. At 1 year, 58.6%, 57.7%, and 57.1% of patients receiving ATB, IM, and ATB+IM, respectively, achieved the treatment endpoint [≤4 sites with a probing depth (PD) of ≥5 mm], compared with 23.1% in the SI group (<i>p</i> = 0.023). Each adjunctive therapy resulted in a greater reduction in the number of sites with PD≥5 mm compared with SI (<i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Adjunctive ATB, IM, or ATB+IM each provided clinically meaningful benefits beyond mechanical therapy. The results suggested no added benefit from combining ATB and IM. These findings support MTZ + AMX or ω-3 + ASA, without routine combination, as effective adjuncts in periodontal treatment and provide a basis for precision-based trials and data-driven models to identify patients most likely to benefit from each approach. ensaiosclinicos.gov.br RBR-7nh566t</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>This study explored whether adding antibiotics or anti-inflammatory supplements (omega-3 and low-dose aspirin), either alone or in combination, could enhance the results of subgingival instrumentation (non-surgical periodontal therapy) in patients with severe periodontitis. All participants received the standard periodontal treatment and were randomly assigned to also take a placebo, antibiotics, omega-3 with aspirin, or a combination of both therapies. After 1 year, patients who received any of the additional therapies showed greater ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1454-1466"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Donald F. Adams, DDS, MS, FACD","authors":"","doi":"10.1002/jper.70138","DOIUrl":"10.1002/jper.70138","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148286399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does timing of systemic antibiotics influence periodontal treatment outcomes? A randomized clinical trial","authors":"Daiane Fermiano, Eduardo de Souza Oliveira, Maria Josefa Mestnik, Luciene C. Figueiredo, Takahiko Shiba, Shunsuke Matsumura, Edson de Sousa, Helio Doyle, Rafael Oliveira Dias, Marcelo de Faveri, Magda Feres","doi":"10.1002/jper.70057","DOIUrl":"10.1002/jper.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study is to determine whether the timing of metronidazole (MTZ) and amoxicillin (AMX) administration, relative to scaling and root planing (SRP), influences the clinical and microbiological outcomes of periodontal treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this double-blind, placebo-controlled, randomized clinical trial, subjects with stage III/IV periodontitis were assigned to receive SRP over 14 days with either (1) MTZ+AMX three times a day (TID) during SRP followed by placebo (<i>early</i> antibiotic group) or (2) placebo during SRP followed by MTZ + AMX TID immediately after SRP (<i>late</i> antibiotic group). Clinical parameters (probing depth [PD], clinical attachment level [CAL], visible plaque, bleeding on probing, suppuration) were recorded at baseline, 3 months and 1 year. Subgingival biofilm samples from nine sites per subject were individually analyzed using checkerboard DNA–DNA hybridization targeting 40 bacterial species. Bacterial correlation networks were constructed using SparCC and visualized in Cytoscape based on the bacterial abundance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-eight subjects were included in the study, with 34 per group. Both groups achieved comparable clinical improvements. Approximately 60% of participants in each group reached the primary treatment endpoint at 1 year (≤ 4 sites with PD ≥ 5 mm at 1 year; <i>p</i> > 0.05), and the reductions in PD and CAL did not differ significantly between groups (<i>p</i> > 0.05). Microbiologically, the <i>early</i> antibiotic group demonstrated faster and more pronounced ecological reorganization, with reduced centrality of red and orange complex species and earlier integration of health-associated taxa such as <i>Actinomyces</i> spp. In contrast, the <i>late</i> group showed slower microbial restructuring, with <i>Actinomyces</i> taxa remaining entangled with orange-complex organisms and persistent dysbiotic clusters dominated by <i>Fusobacterium</i> subspecies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While the timing of antibiotic administration relative to SRP did not influence the overall clinical efficacy of periodontal treatment, initiating antibiotics on the first day of mechanical debridement promoted a more rapid and beneficial restructuring of the subgingival microbial community.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>When treating severe gum ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1395-1406"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of artificial intelligence-based deep learning models in detecting furcation involvement: A systematic review and meta-analysis","authors":"Momen A. Atieh, Maanas Shah, Abeer Hakam, Omar Al-Karadsheh, Siraj Zabadi, Fawaghi AlAli, Nisheta Sachdev, Andrew Tawse-Smith, Nabeel H. M. Alsabeeha","doi":"10.1002/jper.70055","DOIUrl":"10.1002/jper.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Furcation involvement complicates the management of periodontitis and increases the risk of tooth loss. Conventional methods of detection, such as probing and two-dimensional radiographs, are limited by operator variability and anatomical complexity. Deep learning has shown a potential to detect furcation involvement on radiographic images. The aim of this review was to systematically evaluate the diagnostic potentials of deep learning models in detecting furcation involvement on radiographic images.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Systematic search was conducted in PubMed, EMBASE, CENTRAL, ClinicalTrials.gov and ProQuest for studies published from 2010 to September 2025. Two reviewers independently screened studies, extracted data, and assessed quality using QUADAS-2. Diagnostic metrics (sensitivity, specificity, F1-score, area under the curve (AUC)) were pooled using random-effects meta-analysis. Heterogeneity and publication bias were assessed via <i>I</i><sup>2</sup> statistics, meta-regression, and funnel plots.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight studies, including 7814 radiographs of 12,373 molars (periapical, panoramic, cone-beam computed tomography), were analyzed. Deep learning models demonstrated high accuracy: sensitivity 0.93, specificity 0.94, diagnostic odds ratio (DOR) 187, AUC 0.97 with mandibular molars reflecting higher accuracy (sensitivity 0.96, specificity 0.97, DOR 631, AUC 0.99). Fagan plot analysis indicated strong clinical utility. Meta-regression showed no significant effect of dataset type, augmentation, or number of annotators. No publication bias was detected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Deep learning models show promising accuracy in detecting furcation involvement, particularly in mandibular molars, comparable to expert clinicians. Further refinement with larger, diverse datasets is needed to reduce false positives and enable safe clinical integration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>Furcation involvement, a condition where the bone between the roots of a tooth is lost, makes managing gum disease more difficult and increases the risk of tooth loss. Clinical probing remains a reliable and essential method for detecting this condition, while dental X-rays can provide complementary information, particularly in complex cases. This study reviewed the use of deep learning, a type of artificial intelligence (AI), to detect furcation involvement on dental X-rays. Data from eight studies, including more than 7,","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1559-1574"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}