Journal of periodontology最新文献

{"title":"Surgical- and implant-related factors and onset/progression of peri-implant diseases: An AO/AAP systematic review","authors":"Alberto Monje, Shayan Barootchi, Paul S. Rosen, Hom-Lay Wang","doi":"10.1002/JPER.24-0083","DOIUrl":"10.1002/JPER.24-0083","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The objective of this systematic review was to shed light on the importance of surgical- and implant-related factors on the onset/progression of peri-implant diseases. This systematic review provides an evidence-based overview on the prevention of peri-implant diseases for the Academy of Osseointegration (AO)/American Academy of Periodontology (AAP) Consensus Conference held in August 14–16, 2024 in Oakbrook, IL, USA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Systematic screening of electronic sources was performed to identify clinical studies reporting on the impact of surgical- and implant-related factors on peri-implant diseases. To fulfil the inclusion criteria, a composite clinical and radiographic case definition for peri-implant mucositis and/or peri-implantitis had to be reported. Prevalence or incidence (%) of peri-implant diseases was extracted at patient- and implant-level. Moreover, odds/hazard ratios were collected to explore potential associations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 34 articles were included in the qualitative synthesis. Of these, 21 explored surgical-related factors (<i>N</i><sub>patients </sub>= 2752, <i>N</i><sub>implants </sub>= 7591), while 13 reported implant-related factors (<i>N</i><sub>patients </sub>= 1192, <i>N</i><sub>implants </sub>= 4072). Given the high heterogeneity across the studies, only qualitative assessment was performed. Clinical evidence proved that surgical-related factors, in particular inadequate implant position and, to a lower extent, implants placed in regenerated bone, are more prone to exhibit peri-implantitis, but not peri-implant mucositis. With regards to specific implant-related factors, insufficient evidence, did not allow for exploring specific associations with the onset/progression of peri-implant diseases. However, it was found that a short distance from the prosthetic margin to crestal bone during implant placement may be a predisposing factor for peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Clinical evidence linking surgical- and implant-related factors and peri-implant diseases is sparsely reported in the literature. Nevertheless, it appears that implant malposition plays a crucial role on the onset/progression of peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain Language Summary</h3>\u0000 \u0000 <p>The objective of this systematic review was to shed light on the importance of surgical-and implant-","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"96 6","pages":"542-561"},"PeriodicalIF":3.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.24-0083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing circular cortical-lamina anchoring versus split-crest technique in posterior mandible: A retrospective cohort study.","authors":"Xinyi Wang, Liqing Yang, Chengyu Li, Rui Bao, Xuan Guan, Zehong Guo","doi":"10.1002/JPER.24-0733","DOIUrl":"https://doi.org/10.1002/JPER.24-0733","url":null,"abstract":"<p><strong>Background: </strong>This retrospective study aimed to assess the effect of horizontal bone augmentation using the circular cortical-lamina anchoring technique (CCA) and modified split-crest technique (MSC) on the knife ridge of the posterior mandible.</p><p><strong>Methods: </strong>Patients who underwent horizontal bone augmentation in posterior mandible sites between 2018 and 2023 were reviewed and divided into MSC and CCA groups based on the procedure performed. Clinical and cone-beam computed tomography data were recorded to evaluate the horizontal bone width at 1, 3, 5, and 7 mm below the crest; buccal width change; alveolar ridge width resorption during the healing period; and keratinized mucosa change.</p><p><strong>Results: </strong>This study examined 48 sites (CCA, 24; MSC, 24) in 39 patients (CCA, 21; MSC, 18). At baseline, there was no significant difference in alveolar ridge width between the two groups. Both groups showed significant horizontal ridge augmentation after healing (CCA: 4.25 ± 1.11 mm; MSC: 2.97 ± 0.36), and the average bone gain was more in the CCA group (p < 0.001). Both groups showed a significant horizontal bone width increase at 3 mm below the crest (CCA: 4.99 ± 1.60 mm; MSC: 3.34 ± 0.78 mm). Besides, compared with the CCA group, an increase in keratinized mucosa was observed in the MSC group after the healing period (CCA: -0.72 ± 0.36 mm; MSC: 3.40 ± 1.03 mm; p < 0.001).</p><p><strong>Conclusion: </strong>This study demonstrated that both the CCA and MSC could achieve effective horizontal augmentation, with the CCA presenting a similar spatial maintenance ability during the healing process along with increased bone gain. Therefore, the CCA can be considered as an effective alternative to the MSC.</p><p><strong>Clinical trial registration number: </strong>ChiCTR2400084525.</p><p><strong>Plain language summary: </strong>This study compared two methods to widen the bone at the back of the lower jaw: circular cortical-lamina anchoring (CCA) and modified split-crest technique (MSC). We checked 39 patients who underwent these procedures from 2018 to 2023 and measured the width of the bones and the changes in soft tissue after the operations. Initially, the size of the jawbones was similar. After the operations, both groups had wider jawbones and the bones in the CCA group showed more growth (4.25 mm on average) than the bones in the MSC group (2.97 mm on average). The best results were seen at 3 mm below the top of the jawbone. Therefore, both methods can make the jawbone wider, but the CCA method seems to be better suited for growing more bone. The CCA could be a good alternative to the MSC for patients who require widening of their jawbone for implantation.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainability of regular use of interdental cleaning tools in periodontally healthy individuals","authors":"Mert Yılmaz, Timur Köse, Nurcan Buduneli","doi":"10.1002/jper.24-0551","DOIUrl":"https://doi.org/10.1002/jper.24-0551","url":null,"abstract":"BackgroundThe aim of this study was to compare the sustainability of regular use of 2 different interdental cleaning tools in 24 weeks by periodontally healthy individuals as a component of primary prevention.MethodsPeriodontally healthy individuals were randomly assigned to dental floss or rubber interdental pick group. Participants received an oral care kit and a calendar to record the times they used the floss/pick. Full‐mouth scores of plaque and bleeding were recorded. They were recalled on the 8th and 24th weeks, and asked to bring back the waste of the interdental cleaning tools. Regular use was defined as using the tool ≥ 3 days/week, and sustainability is the number of weeks with regular use. Data were analyzed using appropriate statistical tests.ResultsFifty‐four participants completed the study protocol. Of these, 28 were in the rubber interdental pick, and 26 were in the dental floss group. In the rubber pick group, the mean number of weeks with regular use was 12.61 out of 24 weeks, while it was 4.96 in the dental floss group. The difference between the study groups in terms of the sustainability of regular use of the interdental cleaning tool was statistically significant (<jats:italic>p</jats:italic> = 0.003). Plaque and bleeding scores were similar in the study groups at baseline and recall (<jats:italic>p</jats:italic> &gt; 0.05), and negatively correlated with the number of weeks with regular use (<jats:italic>p</jats:italic> &lt; 0.05).ConclusionWithin the limits of this study, the use of rubber interdental picks can be recommended for superior sustainability in periodontally healthy individuals, provided that the interdental space allows passage.Plain Language SummaryThis study compared how well rubber interdental picks and dental floss work over 6 months for people with healthy gums. It aimed to find out which tool people use more consistently. Interdental cleaning is important because brushing alone does not remove all the plaque. Regular cleaning between teeth helps to prevent gum diseases and tooth decay. Fifty‐four volunteers with healthy gums were divided into 2 groups: 1 group used rubber interdental picks, and the other used dental floss. Participants were instructed to use their assigned tool daily and follow a regular oral care routine. Their usage and oral health were monitored throughout the study. Results showed that people used rubber interdental picks more regularly than dental floss. On average, those using picks continued for about 12.6 weeks out of 24 weeks, while floss users maintained the habit for approximately 5 weeks. As a conclusion, rubber interdental picks seem to be more likely to be used consistently and can be more effective for maintaining gum health compared to dental floss.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"6 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Forum Poster Session and Competition: Winners","authors":"","doi":"10.1002/jper.25-0164","DOIUrl":"https://doi.org/10.1002/jper.25-0164","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized clinical trial evaluating kinetic benefits of desensitizing agents: Magnitude, onset, and stability of relief","authors":"Aaron R. Biesbrock, Tao He, Yuanshu Zou, Julie M. Grender, Pejmon Amini, Paul A. Sagel, Andrew Groth, Malgorzata Klukowska","doi":"10.1002/jper.24-0688","DOIUrl":"https://doi.org/10.1002/jper.24-0688","url":null,"abstract":"BackgroundDentin hypersensitivity (DH) is common, particularly among periodontal patients. This trial evaluated magnitude of desensitizing benefit, onset of action, and complete relief of three dentifrices with distinct desensitizing technologies.MethodsHealthy adults with DH were enrolled and randomized to one of four dentifrices in this randomized, controlled, double‐blind trial: marketed potassium nitrate (KNO&lt;jats:sub&gt;3&lt;/jats:sub&gt;), marketed stannous fluoride (SnF&lt;jats:sub&gt;2&lt;/jats:sub&gt;), experimental 1.5% oxalate, or negative control (NC) monofluorophosphate. Participants brushed with their assigned dentifrice twice daily for 8 weeks, followed by 3 weeks during which all participants used the NC. DH was measured by thermal challenge (Schiff Index) and tactile challenge (Yeaple Probe) at baseline, Day 3, and Weeks 2, 4, 8, and 11.ResultsA total of 120 participants were randomized to treatment, and 118 completed the study. &lt;jats:italic&gt;Thermal challenge (Schiff)&lt;/jats:italic&gt;: All treatments provided greater relief than NC at all timepoints (&lt;jats:italic&gt;p&lt;/jats:italic&gt; ≤ 0.004). The SnF&lt;jats:sub&gt;2&lt;/jats:sub&gt; dentifrice had greater thermal improvements than KNO&lt;jats:sub&gt;3&lt;/jats:sub&gt; dentifrice at Week 2 (&lt;jats:italic&gt;p&lt;/jats:italic&gt; = 0.021) and in a random coefficients model across all timepoints (&lt;jats:italic&gt;p&lt;/jats:italic&gt; = 0.015). The percentage of participants showing complete relief in at least one test tooth was greater for SnF&lt;jats:sub&gt;2&lt;/jats:sub&gt; versus KNO&lt;jats:sub&gt;3&lt;/jats:sub&gt; through Week 8 (all &lt;jats:italic&gt;p&lt;/jats:italic&gt; ≤ 0.044). &lt;jats:italic&gt;Tactile challenge&lt;/jats:italic&gt; (&lt;jats:italic&gt;Yeaple Probe)&lt;/jats:italic&gt;: All treatments provided greater tactile sensitivity relief than NC at all timepoints (&lt;jats:italic&gt;p&lt;/jats:italic&gt; ≤ 0.019), except KNO&lt;jats:sub&gt;3&lt;/jats:sub&gt; at Day 3 (&lt;jats:italic&gt;p&lt;/jats:italic&gt; = 0.197). The SnF&lt;jats:sub&gt;2&lt;/jats:sub&gt; dentifrice had greater improvements in tactile scores versus the KNO&lt;jats:sub&gt;3&lt;/jats:sub&gt; dentifrice at Day 3 (&lt;jats:italic&gt;p&lt;/jats:italic&gt; = 0.020).ConclusionSnF&lt;jats:sub&gt;2&lt;/jats:sub&gt;, KNO&lt;jats:sub&gt;3&lt;/jats:sub&gt;, and oxalate dentifrices significantly reduced DH over 8 weeks. SnF&lt;jats:sub&gt;2&lt;/jats:sub&gt; dentifrice showed the greatest benefits for onset of relief, magnitude of benefit, and complete relief.Trial RegistrationNCT03965039Plain Language SummaryThis study tested four toothpastes for sensitivity relief, including speed and completeness of relief, among approximately 120 adults with sensitive teeth. They were randomly assigned to use one of four toothpastes: commercial toothpaste with potassium nitrate, commercial toothpaste with stannous fluoride, experimental toothpaste with oxalate, or standard fluoride toothpaste (control) with no antisensitivity ingredient. Participants used their toothpaste twice daily for 8 weeks, and then everyone used the control toothpaste for 3 weeks. Sensitivity was measured at the beginning of the study, after 3 days, and after 2, 4, 8, and 11 we","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"81 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative long‐term augmentation stability of L‐ and I‐shaped guided bone regeneration techniques for maxillary anterior region","authors":"Jae‐Hong Lee, Yeon‐Tae Kim","doi":"10.1002/jper.24-0867","DOIUrl":"https://doi.org/10.1002/jper.24-0867","url":null,"abstract":"BackgroundThis study evaluated the efficacy of L‐ and I‐shaped collagenated block bone substitutes (BBS) compared with particulate bone substitutes (PBS) in guided bone regeneration (GBR) of maxillary anterior peri‐implant dehiscence defects. It focused on radiographic, profilometric, esthetic, and patient‐reported outcomes over a 4‐year follow‐up period.MethodsFifty‐one peri‐implant defects were treated with L‐shaped (GBR‐L, <jats:italic>n </jats:italic>= 16), I‐shaped (GBR‐I, <jats:italic>n </jats:italic>= 14), and PBS (GBR‐P, <jats:italic>n </jats:italic>= 21) grafts. Hard and soft tissue profiles based on cone beam computed tomography (CBCT) and oral scans, esthetic outcomes based on pink and white esthetic scores (WES) and Mucosal Scar Index (MSI), and patient‐reported measures based on the Oral Health Impact Profile‐14 (OHIP‐14) were evaluated. Statistical analyses (chi‐squared, Mann–Whitney <jats:italic>U</jats:italic>, Kruskal–Wallis tests) compared groups at baseline, implant surgery, re‐entry, and 4‐year follow‐up.ResultsAt early follow‐up, significant differences in hard and soft tissue profiles were observed at the implant shoulder and 45° positive angles between the GBR‐L, GBR‐I, and GBR‐P groups (<jats:italic>p</jats:italic> &lt; 0.05). However, these differences diminished over time, and no statistically significant differences remained at the 4‐year follow‐up. Similarly, esthetic and patient‐reported outcomes showed no significant differences among the groups.ConclusionsWithin the limitations of this study, the use of L‐ or I‐shaped collagenated BBS in GBR showed no significant radiographic, profilometric, esthetic, or patient‐related differences compared to GBR with PBS over 4 years of long‐term follow‐up. In particular, the significant volumetric shrinkage observed with collagenated BBS may affect the long‐term stability of the GBR procedure.Plain Language SummaryThis study focused on improving the success of dental implants in the maxillary anterior region, a challenging region due to esthetic and structural requirements. The researchers compared three methods of guided bone regeneration (GBR) using different types of bone graft substitutes: L‐shaped, I‐shaped, and particulate materials. They monitored bone and gum stability, appearance, and patient satisfaction over 4 years. Initial results showed slight differences in bone and gum support between the methods, but these differences disappeared by the end of the study. All approaches produced similar results in terms of long‐term stability, esthetic appearance, and patient satisfaction. The results provide guidance to dentists in their choice of GBR techniques for dental implants, emphasizing that different methods can achieve comparable long‐term success when used carefully.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"2 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentrated growth factor with guided tissue regeneration for shallow infrabony defects: A one-year prospective study.","authors":"Siniong Iao,Xiangying Ouyang,Yan Huang,Jianru Liu,Wenyi Liu","doi":"10.1002/jper.24-0728","DOIUrl":"https://doi.org/10.1002/jper.24-0728","url":null,"abstract":"BACKGROUNDThis study evaluated the efficacy of concentrated growth factor (CGF) sticky bone combined with guided tissue regeneration (GTR) in treating shallow infrabony defects and explored factors influencing clinical outcomes.METHODSThirteen patients with 31 shallow defects (≤3 mm) were treated using CGF sticky bone (CGF + deproteinized bovine bone mineral), covered with a collagen membrane and CGF membrane. Probing depth (PD), clinical attachment level (CAL), and gingival recession (REC) were examined at baseline and 1 year post surgery. The distance between the base of the defect and the cementoenamel junction (BD-CEJ) were measured on periapical radiographs. Gingival volume and thickness were assessed with digital intraoral scans. Linear regression identified factors influencing CAL gain, PD reduction, and bone gain (ΔBD-CEJ).RESULTSOne year post surgery, CAL increased by 2.48 ± 1.72 mm (p < 0.001), PD reduced by 2.90 ± 1.40 mm (p < 0.001), and bone gain was 2.46 ± 1.71 mm (p < 0.001). REC remained stable (p = 0.254), and the volume and thickness of gingival contour showed no significant changes (p = 0.751 and p = 0.915, respectively). Greater baseline attachment loss was associated with higher CAL gain (coefficient 0.436, p = 0.001). Deeper preoperative PD predicted greater PD reduction (coefficient 0.573, p = 0.029). Greater bone gain was correlated with lower baseline bone height (coefficient 0.305, p = 0.018).CONCLUSIONSCGF sticky bone combined with GTR demonstrates benefits in CAL gain, PD reduction, and bone gain while preventing REC and gingival contour collapse in the treatment of shallow infrabony defects with residual pockets after initial therapy.CLINICAL TRIAL REGISTRATIONChinese Clinical Trial Registry (ChiCTR2300069617).PLAIN LANGUAGE SUMMARYThis study explored a novel approach to treating shallow bone defects around teeth using a combination of concentrated growth factor (CGF) sticky bone and guided tissue regeneration (GTR). The treatment involved using a specially prepared bone graft material (CGF sticky bone) along with a collagen membrane and a CGF membrane. The researchers tracked the changes in gum and bone health in 13 patients with 31 shallow defects over 1 year. The results showed significant improvements: Gum attachment levels increased by an average of 2.48 mm, gum pockets reduced by 2.90 mm, and bone growth averaged 2.46 mm. Notably, gum recession and gingival contour remained stable, meaning the treatment did not compromise the appearance of the gums. The study also found that patients with worse gum or bone loss at the start of the treatment tended to experience the greatest improvements. These findings suggest that CGF sticky bone combined with GTR is a promising option for restoring shallow bone defects, particularly in cases where traditional therapy has left residual gum pockets.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"128 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of soft tissue augmentation in the maxillary esthetic region: A 5-year randomized controlled trial.","authors":"Elise G Zuiderveld,Gerry M Raghoebar,Arjan Vissink,Barzi Gareb,Henny J A Meijer","doi":"10.1002/jper.24-0660","DOIUrl":"https://doi.org/10.1002/jper.24-0660","url":null,"abstract":"BACKGROUNDSoft tissue grafting at dental implant sites has been proposed to enhance esthetic outcomes. A xenogeneic collagen matrix (XCM) was introduced as an alternative grafting material to connective tissue. Only short-term results are yet available.METHODSSixty patients were treated in a randomized controlled trial with a connective tissue graft (n = 20, CTG group), an XCM (n = 20, XCM group), or received no graft (n = 20, NG group). The grafts were placed at the time of implant placement in a preserved alveolar ridge. The primary outcome was a change in mid-buccal mucosal level (MBML) after 5 years (T60). Secondary outcomes were marginal bone level, clinical peri-implant parameters, esthetics, and patient satisfaction.RESULTSAt T60, mean changes in MBML were -0.41 ± 1.20 mm, -0.30 ± 1.22 mm, and -0.61 ± 1.72 mm in the CTG, XCM, and NG groups (p = 0.78), respectively. Also, regarding the secondary outcome variables, no significant between-group differences were observed.CONCLUSIONSSoft tissue grafting at single implant placement after alveolar ridge preservation, either with a CTG or XCM, does not result in a better esthetic outcome and should not be considered as a standard procedure.PLAIN LANGUAGE SUMMARYImplant placement in case of a failing tooth is a favorable treatment option. However, since the extraction socket is often associated with a large bone defect, alveolar ridge preservation with bone grafts prior to implant placement is often needed. To compensate for possible soft tissue defects, the application of a CTG or an XCM has been proposed. The question has arisen whether the use of an XCM will give a better outcome than a CTG. Furthermore, are both soft tissue augmentation therapies accompanied by a better esthetic result than performing no soft tissue therapy at all? Therefore, a 5-year study was carried out in which 60 patients with a failing tooth in the frontal region of the upper jaw were treated with removal of the tooth and restoring the gap with bone graft and sealing the socket with mucosagraft from the tuberosity region. At the time of implant placement 5 months thereafter, 20 patients received a CTG, 20 patients received an XCM, and 20 patients no soft tissue therapy. After 5 years, it appeared that there was no difference between the 3 soft tissue treatment procedures. Thus, implant placement combined with soft tissue grafting in preserved alveolar ridges does not result in a better esthetic outcome.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"142 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2020 Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology Posters.","authors":"","doi":"10.1002/jper.25-0114","DOIUrl":"https://doi.org/10.1002/jper.25-0114","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"41 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome analysis of granulation tissue from periodontal osseous defects.","authors":"Ye Han Sam,Ana J Caetano,Dewi R Owen,Giuseppe Mainas,Luigi Nibali,Mandeep Ghuman","doi":"10.1002/jper.24-0821","DOIUrl":"https://doi.org/10.1002/jper.24-0821","url":null,"abstract":"BACKGROUNDGranulation tissue is routinely discarded in periodontal surgical procedures, but few studies have characterized it. The present study aimed to compare global gene expression in granulation tissue derived from different types of periodontal osseous defects.METHODSTotal RNA was isolated from granulation tissue harvested during routine periodontal surgical procedures. Nineteen sites were analyzed-seven infrabony, six suprabony, and six furcation defects. Following quality control checks, samples underwent bulk mRNA sequencing (20-30 million read pairs per sample) before bioinformatic analyses utilizing gene ontology and associated pathway/enrichment analyses.RESULTSNo statistically significant differentially expressed genes (DEG) were detected between different osseous defect types. An increase in the expression of 11 genes with a false discovery rate of <0.05 was detected when a comparison was made in terms of healing duration post nonsurgical periodontal therapy (NSPT). Notably, the genes involved included those regulating collagen synthesis and osteogenic activity. Analysis based on sex differences revealed 38 DEG. Gene enrichment analysis revealed that 24 DEG without Y-linked attachment are mostly involved in immune regulation.CONCLUSIONSRoutinely discarded periodontal granulation tissue exhibits epithelial characteristics due to a substantial period of maturation post NSPT. Confirmation of ongoing maturation beyond traditional periodontal re-evaluation timepoints warrants further investigation on tissue differentiation potential. More research is needed to elucidate the role of sex as a biological variable affecting periodontal immune response.PLAIN LANGUAGE SUMMARYGranulation (wound) tissue is routinely removed during gum (periodontal) surgical procedures, but knowledge on its characteristics is scarce. This study aimed to compare gene expression in granulation tissue derived from different types of periodontal bone defects via high-throughput RNA sequencing. Total RNA was extracted from 95 samples harvested from gum disease patients during surgery. After quality control checks, 19 samples (seven infrabony, six suprabony, and six furcation defects) were eligible for sequencing. Subsequent analyses were done utilizing software with known cell biological pathways and processes. Analysis revealed no differentially expressed genes (DEG) in terms of periodontal defect category. There was statistically significantly increased expression of 11 genes when a comparison was made in terms of healing duration following deep scaling treatment. These genes are involved in collagen synthesis and osteogenic activity. Interestingly, analysis based on sex differences detected 38 DEG. Gene enrichment analysis revealed that 24 DEG without association with Y chromosomes are mostly involved in the regulation of immune system response. Routinely discarded periodontal granulation tissue exhibits lining cell characteristics that change over time following d","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"140 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}