Journal of periodontology最新文献

{"title":"Associations between periodontal inflammation and OHIP-14 scores: A cross-sectional study.","authors":"Luigi Nibali, Yanwen Zheng, Koula Asimakopoulou, Jeremy Redman, Alastair Lomax, Jing Kang","doi":"10.1002/jper.70165","DOIUrl":"https://doi.org/10.1002/jper.70165","url":null,"abstract":"<p><strong>Background: </strong>More evidence is needed to assess the association between periodontitis and Oral Health-Related Quality of Life (OHRQoL) quantitatively. We hypothesized that periodontal inflammation is correlated with a worsening in quality of life and aimed to test this in this study.</p><p><strong>Methods: </strong>A total of 1307 participants in King's Oral Biobank answered the Oral Health Impact Profile-14 (OHIP-14) questionnaire (measurement of OHRQoL) during a dental visit. The associations between periodontal inflammation, measured as periodontal inflamed surface area (PISA) and bleeding on probing (BOP), periodontal conditions (diagnosis/staging), and OHIP-14 scores across all seven domains (functional limitation, physical pain, psychological discomfort, physical disability, psychological disability, social disability, and handicap) were investigated.</p><p><strong>Results: </strong>The PISA exhibited weak linear correlations with the overall OHIP-14 score (Pearson correlation coefficient r = 0.06, p = 0.037), particularly with the \"physical pain\" subdomain (r = 0.12, p < 0.001). BOP was associated with the OHIP overall score (r = 0.08, p = 0.022). In addition, stage IV periodontitis was associated with higher OHIP-14 total scores and with multiple subdomains, including physical pain, physical disability and psychological discomfort.</p><p><strong>Conclusions: </strong>Inflammation indices such as BOP and PISA are associated with worse OHRQoL. In addition, the complex clinical features of stage IV periodontitis may worsen OHRQoL, especially in relation to physical pain, physical disability and psychological discomfort.</p><p><strong>Plain language summary: </strong>This study shows that having more advanced gum disease (stage IV) and gum inflammation may worsen quality of life.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histologic evaluation of alveolar ridge preservation using aseptically processed large-particle demineralized freeze-dried bone allograft: A case series.","authors":"Nikolaos Soldatos, Alakananda Melethil Sreeramadas, Hongseok An, Cristiane Miranda Franca","doi":"10.1002/jper.70181","DOIUrl":"https://doi.org/10.1002/jper.70181","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Demineralized freeze-dried bone allograft (DFDBA) is widely utilized in alveolar ridge preservation (ARP). However, limited human histologic evidence exists characterizing early healing associated with aseptically processed large-particle DFDBA. Both graft processing methodology and particle size may influence regenerative healing dynamics, graft integration, and tissue maturation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Three systemically healthy patients underwent ARP following tooth extraction using aseptically processed large-particle DFDBA (850-2000 µm) and dense polytetrafluoroethylene (d-PTFE) membrane coverage. Core biopsies were harvested at implant placement after 13-17 weeks of healing. Histologic and histomorphometric analyses were performed to evaluate graft integration, newly formed bone, residual graft particles, connective tissue, cellular repopulation, and tissue mineralization patterns.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;All specimens demonstrated active bone formation, graft integration, and cellular repopulation of residual DFDBA particles. Newly formed bone was observed in close apposition to graft particles, consistent with ongoing remodeling and incorporation at the graft-host interface. Mean vital bone formation was approximately 34%, while mean mineralization approached 90%. Residual graft particles remained present at all sites and demonstrated varying degrees of integration into newly formed tissue. Cone beam computed tomography (CBCT) evaluation demonstrated regions of reduced radiopacity suggestive of incomplete mineralization; however, histologic and histomorphometric analyses demonstrated highly mineralized regenerated tissue, highlighting differences between radiographic appearance and tissue maturity during early healing.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Within the limitations of this exploratory case series, aseptically processed large-particle DFDBA demonstrated early healing characterized by graft integration, cellular repopulation of graft particles, vital bone formation, mineralized tissue development, and progressive remodeling following alveolar ridge preservation. Histologic and histomorphometric findings obtained at 13-17 weeks provide direct human evidence regarding early healing patterns associated with a graft configuration defined by both aseptic processing methodology and large particle size. Mean vital bone formation of approximately 35% and mean 90% mineralization were observed during this early healing interval, and all sites demonstrated sufficient clinical development to permit subsequent implant placement.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;When a tooth is removed, the surrounding bone naturally shrinks during healing, which can make future dental implant placement more difficult. One way to reduce this bone loss is alveolar ridge preservation, in which a bone graft is placed into the extraction socket. This study evaluated early healing following ridge preser","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of periodontitis with incidence of metabolic syndrome in Korea: A retrospective cohort study.","authors":"SeoYeon Hwang, Hae-Young Kim, Sangwook Kang, Junesun Kim, Sunmi Song, Gum-Ryeong Park","doi":"10.1002/jper.70169","DOIUrl":"https://doi.org/10.1002/jper.70169","url":null,"abstract":"<p><strong>Background: </strong>Although periodontitis has been linked to systemic conditions such as metabolic syndrome, longitudinal evidence remains limited. This nationwide population-based cohort study aimed to investigate whether periodontal status is associated with the incidence of metabolic syndrome in Korea.</p><p><strong>Methods: </strong>We analyzed data obtained from the National Health Insurance Service-Health Screening cohort (2009-2019), including 43,713 participants aged ≥40 years. Periodontitis was assessed using diagnostic codes and periodontal treatment procedures. Metabolic syndrome was defined based on the modified National Cholesterol Education Program Adult Treatment Panel III criteria. This longitudinal cohort analysis used Cox proportional hazards models to examine the association between baseline periodontitis and the subsequent incidence of metabolic syndrome.</p><p><strong>Results: </strong>During the 9-year follow-up, individuals with severe periodontitis had a significantly elevated risk of developing metabolic syndrome compared with those without periodontitis (hazard ratio [HR] = 1.10; 95% confidence interval [CI]: 1.05-1.16). The association was particularly pronounced in individuals aged 50-59 years (HR = 1.16; 95% CI: 1.10-1.23), indicating a significant interaction between age and periodontal severity (p for interaction = 0.015).</p><p><strong>Conclusions: </strong>These findings suggest that oral inflammatory conditions may be implicated in metabolic health, with the strength of the association varying by age. Thus, age-specific vulnerability should be considered when developing preventive strategies.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc-stabilized stannous fluoride modulates the periodontal microbiome, reducing Fusobacteria, key Gram-negative species, and overall inflammation within an experimental gingivitis clinical trial.","authors":"Kristopher A Kerns, Allison A Naumann, Lay Y Soon, Erik L Hendrickson, Abdelahhad Barbour, Dandan Chen, Harsh M Trivedi, Michael Glogauer, Jeffrey S McLean","doi":"10.1002/jper.70168","DOIUrl":"10.1002/jper.70168","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;This study aimed to evaluate the effects of a dentifrice containing stannous fluoride stabilized with zinc phosphate on subgingival microbiome composition and clinical inflammation during experimental gingivitis, compared with a sodium fluoride control.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This investigation was conducted as a secondary analysis of a randomized, parallel-arm, double-blind, controlled clinical trial. Clinical resolution of experimental gingivitis was assessed using bleeding on probing, gingival index, and plaque index. Deeply sequenced subgingival plaque metagenomic data were analyzed to compare microbial composition and functional potential between a stannous fluoride stabilized with zinc phosphate dentifrice (test) and a sodium fluoride dentifrice (control) over a 21-day experimental gingivitis period.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Use of the stannous fluoride stabilized with zinc phosphate dentifrice was associated with depletion of periodontal disease-associated Gram-negative bacteria, including Fusobacterium nucleatum and multiple Porphyromonas and Prevotella species. This reduction in Gram-negative taxa corresponded with shifts in microbial community metabolic functions and was associated with significantly reduced clinical inflammation compared with the control over the 21-day period.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Short-term use of stannous fluoride stabilized with zinc phosphate may provide additional protection against gingival inflammation by limiting the outgrowth of key periodontal pathogens, including the bridging organism Fusobacterium nucleatum, and by altering plaque functional capacity. These effects were associated with improved periodontal health outcomes compared with a standard sodium fluoride dentifrice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;In this study, we analyzed bacteria within the periodontal pocket using deep metagenomic sequencing to better resolve bacterial species and their functions. Results from this study show that using a toothpaste containing stannous fluoride stabilized with zinc phosphate was associated with the reduction of several important Gram-negative bacteria associated with periodontal disease, including Fusobacterium nucleatum and species of Porphyromonas and Prevotella compared with a control toothpaste. These bacteria are well‑known contributors to gingival inflammation and biofilm maturation. When levels of these specific bacteria decreased within the stannous fluoride treatment group, the overall subgingival microbiome shifted which notably persisted during the subsequent 21-day oral hygiene abstention period in this experimental gingivitis model - resulting in significantly lower clinical inflammation. Our findings suggest that even short‑term use of stannous fluoride stabilized with zinc phosphate may provide added protection against early gingival inflammation. Notably, stannous fluoride stabilized with zinc phosphate appears to limi","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis and breast cancer risk: A systematic review with meta-epidemiological analysis.","authors":"Rhayssa Kuhn Peitoxo, Catiusse Crestani Del Agnese, Mateus Cassol Comassetto, Leandro Machado Oliveira, Patricia Almeida Miguez, Raquel Pippi Antoniazzi","doi":"10.1002/jper.70171","DOIUrl":"https://doi.org/10.1002/jper.70171","url":null,"abstract":"<p><strong>Background: </strong>The association between periodontitis and breast cancer (BC) risk has been reported, but with considerable variability in effect estimates across studies. This meta-epidemiological study aimed to systematically evaluate how methodological characteristics of primary studies influence these reported effect estimates.</p><p><strong>Methods: </strong>Cohort and case-control studies were searched in electronic databases up to February 2025. Study quality was assessed using the Newcastle-Ottawa Scale. Meta-analyses were conducted to estimate risk measures (relative risk [RR] and 95% confidence intervals [CI]). Meta-regression and subgroup analyses were performed to investigate potential variability in effect estimates.</p><p><strong>Results: </strong>Among the 19 included studies, although the overall pooled estimate indicated a 19% higher risk of BC in women with periodontitis compared with those without periodontitis (RR = 1.19; 95%CI, 1.05-1.34), meta-epidemiological analyses showed attenuated estimates in prospective vs. case-control studies (RR = 1.05 vs. 1.54), high- vs. moderate-quality studies (RR = 1.09 vs. 2.10), and adjusted vs. unadjusted analyses (RR = 1.07 vs. 1.48) (p < 0.05).</p><p><strong>Conclusion: </strong>Although a small association between periodontitis and BC risk was observed, its magnitude appears to be overestimated in lower-quality, case-control, and inadequately adjusted studies. These findings underscore the importance of methodological rigor in the interpretation of the evidence.</p><p><strong>Plain language summary: </strong>This meta-epidemiological study, based on a systematic and rigorous literature search, confirmed a modest association between periodontitis and increased breast cancer risk. The strength of this association appears to be inflated by methodological limitations in the primary studies, particularly in case-control designs and in studies with limited adjustment for confounding factors. These findings emphasize the need for high-quality prospective studies to more accurately characterize this relationship.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamins A- and C-augmented platelet-rich fibrin in periodontal intraosseous defects: A randomized clinical trial.","authors":"Dalia Sanaa, Weam Elbattawy, Abdallah Hassan, Sameh Magdeldin, Maha Mokhtar, Taghreed Khaled Abdelmoneim, Karim Fawzy El-Sayed","doi":"10.1002/jper.70173","DOIUrl":"https://doi.org/10.1002/jper.70173","url":null,"abstract":"<p><strong>Background: </strong>Vitamins A and C (VitA+C) are pivotal biomolecules, with synergistic effects, especially in conjoint presence, on cellular pluripotency and regenerative capabilities. This randomized trial aimed to evaluate (VitA+C)-augmented injectable platelet-rich fibrin (i-PRF) versus i-PRF alone with a modified minimally invasive surgical technique (M-MIST) in periodontal intraosseous defects in patients with stage III periodontitis.</p><p><strong>Methods: </strong>This parallel group, two-arm, triple-blinded, randomized controlled trial included patients with stage III grade B periodontitis (n = 28) randomly allocated to the test (VitA+C/i-PRF+M-MIST; n = 14) or the control (i-PRF+M-MIST; n = 14) group. The changes in radiographic linear defect depth (RLDD) (primary outcome), radiographic bone fill (RBF), and radiographic bone density (RBD) were recorded at baseline, 6, and 9 months. Clinical attachment level (CAL), probing depth (PD), gingival margin level (GML), plaque index (PI), and gingival index (GI; secondary outcomes) were recorded at baseline, 3 6, and 9 months. The in vitro release kinetics of VitA and VitC from the i-PRF were characterized over 7 days using high-performance liquid chromatography (HLPC).</p><p><strong>Results: </strong>VitA+C/i-PRF+M-MIST demonstrated a significantly higher RLDD-reduction at 6 months and a higher RBF percentage at 6 and 9 months compared with i-PRF+M-MIST (p < 0.05), with no intergroup differences regarding RBD. Both groups independently demonstrated significant improvements in CAL, PD, GML, RLDD, and BDA over time (p < 0.05). Significantly higher CAL-gain and PD-reduction were evident in the VitA+C/i-PRF+M-MIST group at 9 months (p < 0.05).</p><p><strong>Conclusions: </strong>I-PRF with M-MIST significantly enhance periodontal clinical and radiographic parameters over time. Conjoint vitamin A/C augmentation of i-PRF at the described concentration results in significantly greater improvement in radiographic and clinical parameters of intraosseous defects compared with i-PRF alone.</p><p><strong>Clinical trial registration: </strong>This study was registered in the US National Institutes of Health Clinical Trials Registry (NCT05499598; https://www.</p><p><strong>Clinicaltrials: </strong>gov/).</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of transmucosal probe visualization for peri-implant mucosal phenotype assessment: A cross-sectional study","authors":"Emilio Couso-Queiruga,&nbsp;Manrique Fonseca,&nbsp;Diogo Moreira Rodrigues,&nbsp;Gustavo Avila-Ortiz,&nbsp;Vivianne Chappuis,&nbsp;Clemens Raabe","doi":"10.1002/jper.70062","DOIUrl":"10.1002/jper.70062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study evaluated the diagnostic accuracy of visual assessment of mucosal transparency using a standard periodontal probe (VAT) to differentiate between thin and thick peri-implant mucosal phenotypes, compared to horizontal transmucosal probing (HTP). A secondary objective was to assess facial mucosal thickness (FMT) threshold values for peri-implant mucosa phenotype classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adult subjects with at least one non-molar single implant-supported prosthesis (ISP) were screened. To evaluate VAT, a standard periodontal probe was inserted through the peri-implant sulcus on the midfacial aspect. FMT was measured via HTP using an endodontic spreader.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 247 subjects and 281 ISPs constituted the study population. Setting a 2 mm threshold, 66.2% of sites were classified as thick and 33.8% as thin. Compared to HTP, VAT demonstrated a sensitivity (SE) of 12.6%, a specificity (SP) of 96.2%, a positive predictive value (PPV) of 63%, and a negative predictive value (NPV) of 66%. At the 1.5 mm threshold, 86.1% of sites were thick and 13.9% thin, with 25.6% SE, 96.3% SP, 53% PPV, and 89% NPV. At the 1 mm threshold, 92.2% of sites were thick and 7.8% thin, with 41% SE, 96% SP, 47% PPV, and 95% NPV. Receiver operating characteristic analysis revealed the best-fitting balance for PPV (58%) and NPV (91%) at an FMT of 1.25 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Regardless of the FMT threshold applied, VAT demonstrated limited diagnostic accuracy, in particular for thin phenotypes, proving unreliable for the dichotomic characterization of thin and thick peri-implant mucosal phenotypes. This study was approved by the ethical committee for clinical studies in the canton of Bern, Switzerland (KEK-BE-No. 2023-01962).</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1407-1417"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis during pregnancy: The effect on the gut microbiome and intestinal inflammation","authors":"Richard Bright,&nbsp;Matthew G. Macowan,&nbsp;Keyuan Tian,&nbsp;Tracy Fitzsimmons,&nbsp;Rebecca L. Wilson,&nbsp;Claire T. Roberts,&nbsp;Claus T. Christophersen,&nbsp;Peter M. Bartold,&nbsp;Stephen P. Kidd,&nbsp;Peter S. Zilm","doi":"10.1002/jper.70132","DOIUrl":"10.1002/jper.70132","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontitis has been epidemiologically associated with adverse pregnancy outcomes, but causality remains difficult to establish in humans due to confounding factors. This study uses a controlled murine model to examine the effects of experimentally induced periodontitis on the composition of the gut microbiota and gastrointestinal inflammation during pregnancy.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontitis was induced in pregnant BALB/c mice via oral inoculation with &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt; and &lt;i&gt;Fusobacterium nucleatum&lt;/i&gt; before conception (&lt;i&gt;n&lt;/i&gt; = 20 per group). Pregnancy outcomes, gut histology, systemic inflammatory markers, and microbiome composition, assessed by 16S rRNA sequencing, were evaluated at gestational Day 18.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontitis was confirmed by significant alveolar bone loss. While fetal and placental weights were modestly increased in periodontitis-positive mice, there were no changes in implantation rates or placental efficiency. Systemic inflammatory markers, including C-reactive protein and interleukin-33, were reduced, suggesting pregnancy-specific immunomodulation. Histological analysis revealed significant inflammation in the jejunum and colon of periodontitis-exposed mice. Despite this, alpha and beta diversity metrics of the gut microbiota remained essentially unchanged. Taxonomic shifts were observed at the genus level, with reductions in protective taxa, such as &lt;i&gt;Akkermansia muciniphila&lt;/i&gt; and increases in potentially pro-inflammatory genera, like &lt;i&gt;Desulfovibrio&lt;/i&gt;.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontitis during pregnancy alters gut microbial composition and increases gastrointestinal inflammation without overtly impairing pregnancy outcomes in mice. These findings suggest an association between oral inflammation, intestinal inflammatory changes, and systemic inflammatory modulation during pregnancy. Further studies are warranted to explore long-term maternal and offspring consequences and their relevance to human pregnancy.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study explored how periodontitis during pregnancy can influence the gut and immune system. Periodontitis is already associated with poor pregnancy outcomes, but establishing cause and effect in humans is difficult. To investigate this, the researchers used a controlled mouse model. We induced perio","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1587-1603"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in tooth mobility following non-surgical periodontal therapy: A retrospective cohort study of clinical outcomes","authors":"Georgios S. Chatzopoulos,&nbsp;Larry F. Wolff","doi":"10.1002/jper.70046","DOIUrl":"10.1002/jper.70046","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate the change in clinical tooth mobility following scaling and root planing (SRP) and to identify baseline factors predictive of the 12-month outcome.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This retrospective cohort study utilized de-identified electronic health records from the BigMouth Dental Data Repository. The final cohort consisted of 152 patients, contributing 489 teeth with baseline mobility of Class 1, 2, or 3. The primary outcome was the change in mobility class at 12 months. A multilevel cumulative link model (ordinal logistic regression) was used to determine the association between baseline factors (including splinting status) and the 12-month mobility outcome.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Scaling and root planing resulted in a substantial reduction in tooth mobility. At 12 months, 71.2% of teeth with initial Class 1 mobility and 42.2% of teeth with initial Class 2 mobility became clinically stable (Class 0). The multilevel regression analysis identified several factors significantly associated with higher odds of a less favorable outcome: higher initial mobility, deeper probing depths, furcation involvement, smoking, and diabetes (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). The presence of a splint/stabilization was significantly associated with higher odds of a more favorable mobility outcome (OR = 2.15, &lt;i&gt;p&lt;/i&gt; &lt; 0.01).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Within the limitations of this retrospective study, SRP appears effective in reducing tooth mobility within 1 year. The identified predictors can help clinicians to manage patient's expectations and to highlight cases that may require more intensive therapy or monitoring.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Severe gum disease can cause teeth to become loose, putting them at risk of being lost. This study investigated whether a common “deep cleaning” procedure (non-surgical periodontal therapy) could help to stabilize these loose teeth. We analyzed the de-identified dental records of 152 patients from eight U.S. university clinics, tracking the outcomes of 489 loose teeth for 1 year after treatment. Our results showed that the deep cleaning was very successful. Most teeth, even those that were moderately or severely loose, became significantly firmer. For example, more than 70% of slightly loose teeth became completely stable again. We also identified factors that made a successful outcome l","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1388-1394"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral mucosal wound healing: A photograph-based prospective study","authors":"Benjamin P. J. Fournier,&nbsp;Ngoc Estelle Nguyen,&nbsp;Robert Durand,&nbsp;Clarice Nishio,&nbsp;Julien Strippoli,&nbsp;Maria-Clotilde Carra,&nbsp;Stephane Kerner","doi":"10.1002/jper.70063","DOIUrl":"10.1002/jper.70063","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Oral mucosa heals with minimal scar formation compared with other tissues. The aim of this study was to explore the differential healing properties between keratinized gingiva and non-keratinized alveolar mucosa, and to analyze the healing dynamic of these tissues through a clinical photograph-based prospective study.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Fourteen patients received 26 interdental piezocisions as part of orthodontic therapy. Piezocisions penetrated through the oral mucosa, the periosteum, and the cortical bone. They overlapped both keratinized gingiva and non-keratinized alveolar mucosa. Wounds were evaluated at four time points (1, 3, 8, and 20 weeks) by measuring the Mucosal Scarring Index (MSI) on standardized photographs.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The analysis included 364 incisions evaluated at four time-points. The scar length showed a significant reduction up to 3 weeks in the alveolar mucosa (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) and up to 8 weeks in the gingiva (&lt;i&gt;p&lt;/i&gt; = 0.048). At 1 week, the posterior regions had higher MSI scoring than the anterior regions, particularly in the mandibular alveolar mucosa. No significant changes in the scar length or MSI scores were observed after 8 weeks, indicating stabilization of the healing processes. By 20 weeks, 64.05% and 52.22% of the incisions were devoid of scars in the gingiva and alveolar mucosa, respectively.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The study confirmed that both oral mucosa and gingiva heal with no scar or minimal scarring, following full-thickness incisions. Neither keloid nor hypertrophic scars were observed. No significant differences were found between gingiva and alveolar mucosa in terms of final scar visibility. However, healing outcomes were notably less favorable in the posterior regions, highlighting the influence of anatomical location.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Oral mucosa exhibits minimal scar formation compared with other tissues. Studies evaluating the healing dynamics of the various intraoral tissue types remain limited. This prospective study investigates the healing characteristics of keratinized gingiva and non-keratinized alveolar mucosa, by focusing on scar formation following piezocision. Complete wound closure was observed at all sites 1 week after surgery. More than half of the piezocisions produced no visible scarring. Notably, even though the incisions penetrated the full thickness of the tissue and involved perforation of the vestibular corti","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 7","pages":"1418-1430"},"PeriodicalIF":4.5,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}