Journal of periodontology最新文献

{"title":"Survival rate of teeth adjacent and nonadjacent to dental implants: A retrospective cohort study","authors":"Hsuan-Hung Chen,&nbsp;Guo-Hao Lin,&nbsp;Richard T. Kao,&nbsp;Yu-Ting Yeh","doi":"10.1002/JPER.23-0739","DOIUrl":"10.1002/JPER.23-0739","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this retrospective study was to investigate the risk of tooth loss for teeth adjacent and nonadjacent to dental implants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 787 patients with an average follow-up of 57.1 months were examined to define the tooth loss, cumulative survival rate, and odds ratio (OR) for teeth adjacent versus nonadjacent to implants. A multivariate logistic regression was employed to assess the association between dental history and various recorded etiologies of tooth loss among teeth adjacent to implants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The incidence of tooth loss for teeth adjacent to implants was 8.1% at the tooth level and 15.1% at the patient level, while 0.7% and 9.5% at the tooth and patientlevel for teeth nonadjacent to implants. The 10-year cumulative survival rate for teeth adjacent to implants was 89.2%, and the primary etiology of tooth loss was root fracture (45.2%). The risk of tooth loss among teeth adjacent versus nonadjacent to implants was significantly higher (OR 13.15). Among teeth adjacent to implants, root canal-treated teeth had a significantly higher risk of tooth loss due to root fracture (OR 7.72), a history of existing restoration significantly increased the risk of tooth loss due to caries (OR 3.05), and a history of periodontitis significantly increased the risk of tooth loss due to periodontitis (OR 38.24).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The present study demonstrated that after patients received dental implant treatment, teeth adjacent to implants showed a 13.2-fold higher risk of tooth loss compared to teeth nonadjacent to implants, with the primary etiology being root fracture.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"95 10","pages":"942-948"},"PeriodicalIF":4.2,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0739","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-implant diseases and systemic inflammation: A preliminary analysis from a cross-sectional survey of patients with hypertension","authors":"Marco Orlandi,&nbsp;Nicola Pranno,&nbsp;Vipul Patel,&nbsp;Piero Papi,&nbsp;Bianca Di Murro,&nbsp;Giorgio Pompa,&nbsp;Antonella Polimeni,&nbsp;Claudio Letizia,&nbsp;Jeanie Suvan,&nbsp;Francesco D'Aiuto","doi":"10.1002/JPER.21-0338","DOIUrl":"10.1002/JPER.21-0338","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study was to investigate the association between peri-implant diseases and systemic inflammation assessed by serum C-reactive protein (CRP) levels in a sample of patients with hypertension.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 151 participants with hypertension were included in a cross-sectional study. The population was divided into six groups according to their peri-implant and periodontal status (healthy controls, mucositis, peri-implantitis, periodontitis, periodontitis and mucositis, periodontitis, and peri-implantitis). Linear, logistic regression, and correlation analyses were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CRP levels were statistically significantly higher in participants with periodontitis alone (median 3.2 mg/L, interquartile range [IQR] 1.8, <i>p</i> = 0.012), combined with mucositis (3.10 mg/L, IQR 2.35, <i>p</i> &lt; 0.001) or peri-implantitis (2.7 mg/L, IQR 2.53, <i>p</i> = 0.002) when compared to the healthy controls (1 mg/L, IQR 1.2). This association was independent of age, sex, smoking status, and adiposity differences. Participants with periodontitis with and without peri-implant diseases had the greatest odds of exhibiting CRP &gt; 3 mg/L (odds ratio = 7.3, 95% confidence interval 1.6–33.9).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Peri-implant diseases are associated with systemic inflammation, but the nature of the association should be further investigated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"95 6","pages":"525-534"},"PeriodicalIF":4.2,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.21-0338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between periodontitis and serum anti-malondialdehyde–acetaldehyde antibody concentrations in rheumatoid arthritis: A case-control study","authors":"Joyce A. Lee,&nbsp;Ted R. Mikuls,&nbsp;Harlan R. Sayles,&nbsp;Geoffrey M. Thiele,&nbsp;Michael J. Duryee,&nbsp;Jeffrey B. Payne","doi":"10.1002/JPER.23-0604","DOIUrl":"10.1002/JPER.23-0604","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Malondialdehyde–acetaldehyde (MAA) adducts lead to generation of anti-MAA autoantibodies and have been independently identified in inflamed periodontal and rheumatoid arthritis (RA) tissues. This study evaluates serum samples from RA cases and osteoarthritis (OA) controls to quantify associations between periodontal clinical measures, alveolar bone loss (ABL), and anti-<i>Porphyromonas gingivalis</i>, anti-<i>Prevotella intermedia</i>, and anti-<i>Fusobacterium nucleatum</i> antibody concentrations with anti-MAA antibody concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants (<i>n</i> = 284 RA cases, <i>n</i> = 330 OA controls) underwent periodontal clinical assessments and ABL measurements. Serum immunoglobulin (Ig) A, IgG, and IgM anti-MAA and serum IgG antibacterial antibody concentrations were quantified by enzyme-linked immunosorbent assay (ELISA). Analyses utilized simple linear regression and multivariable adjusted models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant associations of periodontal clinical measures with serum anti-MAA were found. Moderate (<i>p </i>= 0.038 and <i>p </i>= 0.036, respectively) and high ABL (<i>p </i>= 0.012 and <i>p </i>= 0.014, respectively) in RA cases (but not in OA) were positively associated with IgG and IgM anti-MAA. Anti-<i>P. gingivalis</i> and anti-<i>P. intermedia</i> antibody concentrations were positively associated with IgA (<i>p </i>= 0.001 for both), IgG (<i>p </i>= 0.007 and <i>p </i>= 0.034, respectively), and IgM anti-MAA antibody concentrations (<i>p</i> &lt; 0.001 and <i>p </i>= 0.020, respectively), while anti-<i>F. nucleatum</i> was positively associated with IgG anti-MAA (<i>p </i>= 0.042), findings that were similar across groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A positive association was demonstrated between ABL and serum IgG and IgM anti-MAA antibody concentrations that was unique to RA and not observed in OA. Serum anti-<i>P. gingivalis</i>, anti-<i>P. intermedia</i>, and anti-<i>F. nucleatum</i> antibody concentrations displayed significant associations with anti-MAA antibody in both groups. These findings suggest MAA may play a role in the interrelationship between the periodontium and RA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"95 10","pages":"929-941"},"PeriodicalIF":4.2,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiogenic potential in periodontal stem cells from upper and lower jaw: A pilot study","authors":"Hanna Malyaran,&nbsp;Chloé Radermacher,&nbsp;Rogerio B. Craveiro,&nbsp;Mark P. Kühnel,&nbsp;Danny Jonigk,&nbsp;Michael Wolf,&nbsp;Sabine Neuss","doi":"10.1002/JPER.24-0070","DOIUrl":"10.1002/JPER.24-0070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Teeth and supporting oral tissues are attractive and accessible sources of stem cells. Periodontal ligament stem cells (PDLSC) are readily isolated from extracted third molars, and exhibit the ability to self-renew and differentiate into multiple mesodermal cell fates. Clinical experience suggests that the exact location of periodontal defects affects the oral bone remodeling and wound healing. Compared to the mandible, the maxilla heals quicker and more efficiently. Angiogenesis is key in tissue regeneration including dental tissues, yet few studies focus on the angiogenic potential of PDLSC, none of which considered the differences between upper and lower jaw PDLSC (u-PDLSC and l-PDLSC, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Here we studied the angiogenic potential of u-PDLSC and l-PDLSC and compared the results to well-established mesenchymal stem cells (MSC). Cells were characterized in terms of surface markers, proliferation, and vascular endothelial growth factor (VEGF) secretion, and angiogenic assays were performed. Newly formed capillaries were stained with CD31, and their expression of platelet endothelial cell adhesion molecule (PECAM-1), angiopoietin 2 (ANGPT2), and vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2) were measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Periodontal stem cells from the upper jaw showed a higher proliferation capacity, secreted more VEGF, and formed capillary networks faster and denser than l-PDLSC. Gene expression of angiogenesis-related genes was significantly higher in u-PDLSC than in l-PDLSC or MSC, given that culture conditions were suitable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The oral cavity is a valuable source of stem cells, particularly PDLSC, which are promising for oral tissue engineering due to their robust growth, lifelong accessibility, low immunogenicity, and strong differentiation potential. Notably, u-PDLSC exhibit higher VEGF secretion and accelerate capillary formation compared to l-PDLSC or MSC. This study suggests a potential molecular mechanism in capillary formation, emphasizing the significance of precise location isolation of PDLSC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"95 7","pages":"662-672"},"PeriodicalIF":4.2,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.24-0070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140845953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and tissue remodeling mediator expression during gingivitis: A comparison between experimental, naturally occurring gingivitis, and periodontal health","authors":"Yung‐Ting Hsu, Ana M. Chang, Diane Daubert, Frank Roberts, Dandan Chen, Harsh M. Trivedi, Juliana Gomez, Rich P. Darveau","doi":"10.1002/jper.23-0692","DOIUrl":"https://doi.org/10.1002/jper.23-0692","url":null,"abstract":"BackgroundThe aim of this study is to evaluate the immune regulation and tissue remodeling responses during experimental gingivitis (EG) and naturally occurring gingivitis (NG) to provide a comprehensive analysis of host responses. Gingival crevicular fluid (GCF) was obtained from 2 human studies conducted in university settings.MethodsThe EG study enrolling 26 volunteers provided controls for the baseline (Day 0) from healthy disease‐free participants, while Day 21 (the end of EG induction of the same group) was used to represent EG. Twenty‐six NG participants age‐matched with those of the EG group were recruited. GCF samples were analyzed for 39 mediators of inflammatory/immune responses and tissue remodeling using commercially available bead‐based multiplex immunoassays. The differences in GI and mediator expression among groups were determined at a 95% confidence level (<jats:italic>p</jats:italic> ≤ 0.05) by a 2‐way analysis of variance (ANOVA) with a post‐hoc Tukey's test.ResultsOur findings showed that EG had a greater gingival index than NG and was healthy (<jats:italic>p</jats:italic> &lt; 0.01 of all comparisons). Furthermore, EG showed significantly higher levels of MPO (<jats:italic>p</jats:italic> &lt; 0.001), CCL3 (<jats:italic>p</jats:italic> &lt; 0.05), and IL‐1B (<jats:italic>p</jats:italic> &lt; 0.001) than NG. In contrast, NG had increased levels of MIF (<jats:italic>p</jats:italic> &lt; 0.05), Fractalkine (<jats:italic>p</jats:italic> &lt; 0.001), angiogenin (<jats:italic>p</jats:italic> &lt; 0.05), C3a (<jats:italic>p</jats:italic> &lt; 0.001), BMP‐2 (<jats:italic>p</jats:italic> &lt; 0.001), OPN (<jats:italic>p</jats:italic> &lt; 0.05), RANKL (<jats:italic>p</jats:italic> &lt; 0.001), and MMP‐13 (<jats:italic>p</jats:italic> &lt; 0.001) than EG.ConclusionsConsistent with the findings from chronic (NG) versus acute (EG) inflammatory lesions, these data reveal that NG displays greater immune regulation, angiogenesis, and bone remodeling compared to EG.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"51 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140845543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of minimally invasive non-surgical therapy on C-reactive protein, lipoprotein-associated phospholipase A2, and clinical outcomes in periodontitis patients: A 1-year randomized, controlled clinical trial","authors":"Gaetano Isola,&nbsp;Paolo Pesce,&nbsp;Alessandro Polizzi,&nbsp;Antonino Lo Giudice,&nbsp;Marco Cicciù,&nbsp;Frank A. Scannapieco","doi":"10.1002/JPER.23-0518","DOIUrl":"10.1002/JPER.23-0518","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Growing evidence suggests the type of periodontal treatment could differentially influence the reduction of key cardiovascular risk mediators in periodontitis patients. This randomized, controlled clinical trial compared the impact of minimally invasive non-surgical therapy (MINST) with quadrant-wise subgingival instrumentation (Q-SI) on C-reactive protein (CRP) together with lipoprotein-associated phospholipase A₂ (Lp-PLA₂) levels, and clinical periodontal outcomes in patients with periodontitis. Moreover, it was evaluated if baseline CRP levels impacted the efficacy of non-surgical periodontal therapy protocols.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty-two periodontitis patients were enrolled and randomly treated by means of MINST (<i>n</i> = 21) or Q-SI (<i>n</i> = 21). The outcomes assessed were serum CRP and Lp-PLA₂, and periodontal parameters (probing depth [PD], clinical attachment level [CAL], full-mouth bleeding score [FMBS]), at baseline and at follow-ups at 1, 3, and 6 months and at 1 year after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 1 year, MINST significantly reduced, among others, mean PD (<i>p</i> = 0.007), mean CAL (<i>p</i> = 0.007), the number of pockets &gt;4 mm (<i>p</i> = 0.011) and ≥6 mm (<i>p</i> = 0.005), and FMBS (<i>p</i> = 0.048) compared to Q-SI. Generalized multivariate analysis evidenced that high baseline CRP (<i>p</i> = 0.039) and FMBS (<i>p</i> = 0.046) levels, together with MINST treatment (<i>p</i> = 0.007) were significant predictors of PD reduction at 1-year follow-up. Moreover, the Jonckheere–Terpstra test showed that patients with high baseline CRP levels gained more benefits from MINST treatment at 1-year follow-up than they did from Q-SI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients receiving MINST showed a greater reduction in CRP levels than patients with Q-SI after 1 year of follow-up. Moreover, patients with high baseline levels of CRP and Lp-PLA₂ gained more benefits from the MINST approach at 1-year follow-up.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"95 10","pages":"949-962"},"PeriodicalIF":4.2,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140820902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary microbiome and MRP‐8/14 levels in children with gingivitis, healthy children, and their mothers","authors":"Alice Blufstein, Natasa Pejcic, Kathrin Spettel, Bela Hausmann, David Seki, Tugba Ertekin, Julia Hinrichs‐Priller, Sarra Altner, Marion Nehr, Katrin Bekes, Athanasios Makristathis, Oleh Andrukhov","doi":"10.1002/jper.23-0632","DOIUrl":"https://doi.org/10.1002/jper.23-0632","url":null,"abstract":"BackgroundGingivitis is the most common form of periodontal disease among children and adolescents and is associated with disrupted host–microbiome homeostasis. Family is an important factor influencing the prevalence of gingivitis. In the present study, we investigated the salivary microbiome, oral hygiene habits, and the salivary level of myeloid‐related protein (MRP)‐8/14 in children aged 7–12 years with gingivitis, periodontally healthy children, and their mothers.MethodsThis study included 24 children with gingivitis (including four sibling pairs) and 22 periodontally healthy children (including two sibling pairs) and their mothers. The whole saliva was collected, DNA was extracted, the variable V3–V4 region of the eubacterial 16S ribosomal RNA gene was amplified, and sample library preparation was performed according to the Illumina protocol. The salivary levels of MRP‐8/14 were analyzed by ELISA.ResultsAlpha diversity of the salivary microbiome was considerably higher in gingivitis children and mothers of gingivitis children compared to healthy children and their mothers, respectively. Significant differences in beta diversity between healthy and gingivitis children, healthy children and their mothers, and gingivitis children and their mothers were detected. Overall, the number of common core amplicon sequence variants between children and their own mothers was significantly higher than between children and other mothers. The salivary MRP‐8/14 levels in children with gingivitis were significantly higher compared to healthy children; a similar tendency was also mentioned for mothers.ConclusionOur study underlines the importance of family as an essential factor influencing oral health.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"13 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140821138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intermittent fasting on periodontal inflammation and subgingival microbiota","authors":"Ronaldo Lira-Junior,&nbsp;Micheál Mac Aogáin,&nbsp;Eva Crncalo,&nbsp;Neda Rajamand Ekberg,&nbsp;Sanjay H. Chotirmall,&nbsp;Sven Pettersson,&nbsp;Anders Gustafsson,&nbsp;Kerstin Brismar,&nbsp;Nagihan Bostanci","doi":"10.1002/JPER.23-0676","DOIUrl":"10.1002/JPER.23-0676","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Studies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long-term intermittent fasting on periodontal health and the subgingival microbiota.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This pilot study was part of a nonrandomized controlled trial. Overweight/obese participants (<i>n</i> = 14) entered an intermittent fasting program, specifically the 5:2 diet, in which they restricted caloric intake to about a quarter of the normal total daily caloric expenditure for two nonconsecutive days/week. Subjects underwent a thorough clinical and laboratory examination, including an assessment of their periodontal condition, at baseline and 6 months after starting the diet. Additionally, subgingival microbiota was assessed by 16S rRNA gene sequencing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 6 months of intermittent fasting, weight, body mass index, C-reactive protein, hemoglobin A1c (HbA1c), and the cholesterol profile improved significantly (<i>p</i> &lt; 0.05). Moreover, significant reductions were observed in bleeding on probing (<i>p</i> = 0.01) and the presence of shallow periodontal pockets after fasting (<i>p</i> &lt; 0.001), while no significant change was seen in plaque index (<i>p</i> = 0.14). While we did not observe significant changes in α- or β-diversity of the subgingival microbiota related to dietary intervention (<i>p</i> &gt; 0.05), significant differences were seen in the abundances of several taxa among individuals exhibiting ≥60% reduction (good responders) in probing pocket depth of 4–5 mm compared to those with &lt;60% reduction (bad responders).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Intermittent fasting decreased systemic and periodontal inflammation. Although the subgingival microbiota was unaltered by this intervention, apparent taxonomic variability was observed between good and bad responders.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"95 7","pages":"640-649"},"PeriodicalIF":4.2,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140642599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient awareness of the association between periodontal and systemic diseases in an academic setting","authors":"William Carter, Tamanna Tiwari, Satheesh Elangovan, Lonnie Johnson, Karo Parsegian, Sangeetha Chandrasekaran","doi":"10.1002/jper.23-0635","DOIUrl":"https://doi.org/10.1002/jper.23-0635","url":null,"abstract":"Periodontal diseases (PD) have been increasingly associated with several systemic conditions such as cardiovascular disease (CVD), diabetes mellitus (DM), rheumatoid arthritis (RA), and Alzheimer's disease (AD). This study aimed to gain insight into patients’ awareness of the association between PD and systemic diseases.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"7 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140550364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of periodontitis with gastrointestinal tract disorders: A bidirectional Mendelian randomization study","authors":"Yuqiang Wang,&nbsp;Jiakang Zhu,&nbsp;Ying Tang,&nbsp;Cui Huang","doi":"10.1002/JPER.23-0560","DOIUrl":"10.1002/JPER.23-0560","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The bidirectional link of periodontitis (PD) and gastrointestinal tract (GIT) disorders has been investigated in previous epidemiological studies; however, the conclusions still remain controversial. The aim of this study was to comprehensively explore the bidirectional causal effect between PD and various GIT diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Based on summary-level data of genome-wide association studies (GWASs), a two-sample bidirectional Mendelian randomization (MR) study was undertaken. Single-nucleotide polymorphisms (SNPs) associated with PD or GIT disorders (chronic gastritis [CG], gastric ulcer [GU], duodenal ulcer [DU], gastroesophageal reflux disease [GERD], irritable bowel syndrome [IBS], and diverticular disease of the intestine [DI]) in GWASs were applied as exposure. The primary method employed was the inverse-variance weighted (IVW) method, and several sensitivity analyses were performed to investigate potential pleiotropy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>With regard to the investigation of the causality between PD and GIT disorders, the IVW method revealed that there is a causal impact of PD on GU (odds ratio [OR] 1.088; 95% confidence interval [CI], 1.036–1.141; adjusted <i>p</i> = 0.004) and DI (OR 0.938; 95% CI, 0.911–0.965; adjusted <i>p</i> = 0.000). However, no significant genetic liability was observed for the causal effect of PD on CG, DU, GERD, and IBS. Furthermore, the primary analysis did not demonstrate a causal effect of GIT disorders on PD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This MR study suggests that PD may be associated with an increased risk of GU and a reduced risk of DI, with possibly limited clinical relevance. Further studies are needed to support the conclusions of this MR study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"95 10","pages":"1002-1010"},"PeriodicalIF":4.2,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}