泛免疫炎症值与牙周炎之间的 U 型关系Nhanes 2009-2014。

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Huan Zhou, Shusen Zhang, Di Miao, Ruoyan Cao
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引用次数: 0

摘要

背景:本研究旨在通过全国性大型调查,研究泛免疫炎症值(PIV)与牙周炎之间的关系:本研究旨在基于一项大型全国性调查,探讨泛免疫炎症值(PIV)与牙周炎之间的关系:本横断面研究的数据来自 2009-2014 年全国健康与营养调查(NHANES),共有 10,300 名参与者。牙周炎的分类基于 2017 年的分类方案。PIV 用公式确定:(中性粒细胞计数×单核细胞计数×血小板计数)/淋巴细胞计数。采用限制性三次样条分析和加权多变量逻辑回归分析来评估PIV与牙周炎之间的关联:结果:PIV 与 III/IV 期牙周炎的关系呈 U 型(Pnon-linearity Q4vs2 = 1.72,95% CI:1.36-2.18),与高血压患者(ORQ4vs2 = 1.78,95% CI:1.38-2.28)的关系呈显著的交互作用(Pinteraction 结论:PIV 与牙周炎的关系呈 U 型,与高血压患者(ORQ4vs2 = 1.78,95% CI:1.38-2.28)的关系呈显著的交互作用(Pinteraction):PIV与III/IV期牙周炎之间存在U型关系,这表明PIV可能是牙周炎的一种辅助治疗策略。在男性和高血压患者中,较高的 PIV 值与 III/IV 期牙周炎的相关性更强。白话摘要:美国成年人的泛免疫炎症值与牙周炎之间存在 U 型关联,表明保持适度的免疫炎症反应对牙周健康至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
U-shaped association between pan-immune-inflammation value and periodontitis: NHANES 2009-2014.

Background: This study aimed to investigate the relationship between the pan-immune-inflammation value (PIV) and periodontitis based on a large national survey.

Methods: In the present cross-sectional study, data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009-2014, which included a total of 10,300 participants. The categorization of periodontitis was based on the 2017 classification scheme. The PIV was determined using the formula: (neutrophils count × monocyte count × platelet count)/lymphocytes count. Restricted cubic spline and weighted multivariable logistic regression analyses were employed to evaluate the associations between the PIV with periodontitis.

Results: The associations between PIV and stage III/IV periodontitis followed a U-shaped pattern (Pnon-linearity < 0.001). The risk of developing stage III/IV periodontitis showed an increasing trend among participants in the first quartile (odds ratio [OR] = 1.21; 95% confidence interval [CI]: 1.01-1.46), third quartile (OR = 1.34; 95% CI: 1.11-1.61), and fourth quartile (OR = 1.47; 95% CI: 1.25-1.73) compared to those in the second quartile. Subgroup analysis indicated stronger associations of PIV with periodontitis in males (ORQ4vs2 = 1.72, 95% CI: 1.36-2.18) and individuals with hypertension (ORQ4vs2 = 1.78, 95% CI: 1.38-2.28) with significant interactions (Pinteraction < 0.05).

Conclusions: There is a U-shaped association between PIV and stage III/IV periodontitis, which suggests a potential adjunctive treatment strategy for periodontitis. Higher PIV values were found to have a stronger correlation with stage III/IV periodontitis in males and individuals with hypertension. Further prospective trials are needed to confirm the validity of our results.

Plain language summary: A U-shaped association exists between the pan-immune inflammation value and periodontitis in US adults, suggesting that maintaining a moderate immune inflammation response is crucial for periodontal health.

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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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