Effects of a 4-week free-sugar avoidance during periodontal therapy: An explorative randomized controlled clinical trial.

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Christina L Pappe, Beeke Peters, Olga Pivovarova-Ramich, Robert Schremmer, Aysegül Adam, Kirstin Vach, Henrik Dommisch, Johan P Woelber
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引用次数: 0

Abstract

Background: This study investigated the effect of a 4-week free-sugar avoidance on periodontal parameters during periodontal therapy.

Methods: Twenty-one patients with untreated periodontitis and daily free-sugar intake were allocated to a sugar avoidance group (SAG) and a control group (CG). The SAG received a 45-min dietary consultation and was instructed to avoid free sugars during the following 4 weeks after subgingival instrumentation, while the CG continued with their regular diet. Bleeding on probing (BOP), plaque control record, body weight (BW), visceral fat (FATv), and a food frequency questionnaire (FFQ) were collected at baseline (T1), 4 weeks (T2), and 8 weeks (T3) after subgingival instrumentation.

Results: The main outcome parameter BOP was significantly reduced at T2 by 40.3% ± 15.54 in the SAG and 34% ± 12.47 in the CG (intra-p value both <0.001, inter-p value 0.361). A linear regression analysis of changes at patient level adjusted for age and FATv revealed a significant group difference for BOP (regression coefficient = -6.8; p = 0.019). Significant reductions were observed in BW, FATv and mean daily intake of free sugars (-14.4 g/day), and a significant increase of vitamin C derived from fruits (75.89 mg/day) at T2 in the SAG only.

Conclusion: This study may indicate additional beneficial effects of a sugar avoidance on periodontal and metabolic parameters, and nutritional intake during periodontal therapy. German Clinical Trials Register (DRKS00026699).

Plain language summary: The current widespread free-sugar consumption is linked to an increasing incidence of chronic non-communicable diseases. Data indicate a relationship between sugar intake and a higher prevalence of periodontitis and increased gingival inflammation. This study showed that free-sugar avoidance after periodontal therapy had additional beneficial effects on periodontal and metabolic parameters in 10 test and 11 control patients. After 4 weeks of avoiding free sugars like sweets, processed white flour, juice, and so forth, periodontal bleeding was significantly reduced in both groups (-40.3% test group, -34% control group). Further regression analysis revealed a significant difference between groups favoring the intervention. Additionally, body weight and visceral fat were significantly reduced in the intervention group, only. To avoid sugar, patients were allowed to replace it with whole fruit, which led to increased levels of micronutrients such as vitamin C. Therefore, free-sugar avoidance may be of therapeutic benefit in addition to periodontal therapy. Further research is needed to investigate this effect in larger cohorts.

牙周治疗期间 4 周无糖忌口的效果:一项探索性随机对照临床试验。
背景:本研究探讨了在牙周治疗过程中,4周无糖饮食对牙周参数的影响:本研究探讨了在牙周治疗过程中,为期 4 周的无糖忌口对牙周参数的影响:21名牙周炎未经治疗且每天摄入游离糖的患者被分配到忌糖组(SAG)和对照组(CG)。龈下器械治疗后的 4 周内,SAG 组接受 45 分钟的饮食咨询,并接受避免摄入游离糖的指导,而 CG 组则继续正常饮食。分别在龈下器械治疗后的基线(T1)、4周(T2)和8周(T3)收集探诊出血量(BOP)、牙菌斑控制记录、体重(BW)、内脏脂肪(FATv)和食物频率问卷(FFQ):结果:主要结果参数 BOP 在 T2 显著降低,SAG 降低了 40.3% ± 15.54,CG 降低了 34% ± 12.47(均为 P 值内):这项研究可能表明,在牙周治疗期间,避免摄入糖分对牙周和代谢参数以及营养摄入有额外的益处。德国临床试验注册(DRKS00026699).纯语言摘要:目前广泛的免费糖消费与慢性非传染性疾病发病率的增加有关。有数据表明,糖的摄入量与牙周炎的高发率和牙龈炎症的增加有关。这项研究表明,在 10 名试验患者和 11 名对照组患者中,牙周治疗后避免摄入游离糖对牙周和代谢参数有额外的益处。在避免食用甜食、加工白面、果汁等游离糖 4 周后,两组患者的牙周出血量均显著减少(试验组-40.3%,对照组-34%)。进一步的回归分析表明,两组之间存在明显差异,有利于干预措施。此外,只有干预组的体重和内脏脂肪明显减少。因此,除了牙周治疗外,避免摄入游离糖可能也有治疗效果。还需要在更大的群体中进一步研究这种效果。
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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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