Journal of periodontology最新文献

{"title":"Melatonin inhibits orthodontically induced root resorption through YAP/P65/IL-6 signaling pathway.","authors":"Tian Wei,Jialin Liu,Peishen Chen,Jie Zhang,Dongyang Li,Liyan Liu,Runze Zhang,Chunmiao Jiang","doi":"10.1002/jper.24-0600","DOIUrl":"https://doi.org/10.1002/jper.24-0600","url":null,"abstract":"BACKGROUNDTo explore the effects and mechanisms of melatonin on orthodontically induced root resorption (OIIRR) by focusing its role on IL-6 secretion in human periodontal ligament cells (hPDLCs).METHODSCytokine array was used to identify the key inflammatory cytokine secreted by hPDLCs under excessive compressive force. Western blot analysis and immunohistochemistry staining (IHC) were conducted to examine the key proteins in the YAP/P65/IL-6 signaling pathway both in in vitro and in vivo experiments. Verteporfin, a YAP inhibitor, was used to confirm the involvement of p-YAP and its downstream signaling factor p-P65. Root resorption volume was assessed using micro-computed tomography (micro-CT).RESULTSCytokine array revealed that excessive compressive force significantly elevated interleukin-6 (IL-6) levels in hPDLCs. IHC indicated that both IL-6 and melatonin receptor 1 (MT1) were highly expressed in hPDLCs on the compressive side in the mouse OIIRR model. in vitro experiments demonstrated that the levels of p-YAP and p-P65 significantly increased when compressive force was applied to hPDLCs, and melatonin reversed this effect. Furthermore, Verteporfin produced effects similar to melatonin on IL-6 expression and the YAP/P65 signaling pathway. Micro-CT analysis showed noticeable root resorption in the mouse OIIRR model, which was significantly reduced following intraperitoneal injection of melatonin. IHC staining further confirmed that the YAP/P65/IL-6 signaling pathway was inhibited on the compressive side of the mouse OIIRR model after melatonin injection.CONCLUSIONSMelatonin was able to inhibit root resorption in the mouse OIIRR model and reduced IL-6 secretion in hPDLCs under compressive force by suppressing the YAP/P65 signaling pathway.PLAIN LANGUAGE SUMMARYThis study explored how melatonin, a natural hormone, protects against root resorption during orthodontic treatment. Specifically, we focused on how excessive compressive force induces IL-6 production and root resorption in both in vitro and in vivo experiments. in vitro, we found that applying compressive force to hPDLCs increased the release of IL-6, a molecule that promotes inflammation and bone resorption. Melatonin, however, reduced IL-6 levels by blocking the YAP/P65 signaling pathway. In vivo, we developed a mouse model of orthodontically induced root resorption, in which melatonin was injected intraperitoneally. Results showed that melatonin reduced root resorption and decreased IL-6 secretion in the periodontal tissues. Additionally, proteins of the YAP/P65 signaling pathway and the RANKL/OPG system were involved in vivo. Our findings suggest that melatonin could be a promising preventive approach to protect against root resorption during orthodontic treatment.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"310 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Titanium migration and bone response in loaded osseointegrated implants: ESEM-EDX analysis in Macaca fascicularis.","authors":"Fausto Zamparini,Andrea Spinelli,Maria Giovanna Gandolfi,Stefano Chersoni,Achille Tarsitano,Giovanni Badiali,Chooi Gait Toh,Carlo Prati,Georgios Romanos","doi":"10.1002/jper.70003","DOIUrl":"https://doi.org/10.1002/jper.70003","url":null,"abstract":"BACKGROUNDTitanium nanoparticle (TP) migration into peri-implant bone may influence osseointegration. It remains unclear how loading protocols may affect TP distribution. This study aimed to detect TP in the bone around implants undergoing different loading protocols in Macaca fascicularis.METHODSNine histological samples containing 21 implants with two loading groups were analyzed. In the delayed-loaded (DL) group (n = 16), the implants were loaded after 3 months and retrieved after 3 months, and in the immediately loaded (IL) group (n = 5), they were loaded on the day of surgery and retrieved after 3 months. Environmental scanning electron microscopy (ESEM) grayscale-level detection and energy-dispersive X-ray spectroscopy (EDX) microchemical analysis were used to assess TP and bone mineralization. Regions of interest (ROI) located at the implant coronal/apical portion (100×) and at the bone-implant interface (1000×) were selected. Bone area distribution (mean% ± SD%) and titanium content were analyzed using two-way analysis of variance (ANOVA) (p < 0.05).RESULTSTitanium granules (2-10 µm) were detected in all regions, with a higher prevalence in the coronal portions of DL implants. In IL implant sections, bone closer to the implants showed a lower prevalence of titanium (p < 0.05). EDX analysis demonstrated a decreasing trend in titanium from the nearest areas to those more distant (up to 2.0 mm). DL implants exhibited lower percentages of mineralized bone compared to IL implants in the coronal portion (mean values 31.0 ± 13.7 and 11.6 ± 2.8) (p < 0.05). IL implants showed a higher percentage of mineralized bone (p < 0.05) in the apical region (mean values 51.8 ± 15.5 and 32.2 ± 15.6).CONCLUSIONTP were widely present in bone tissues adjacent to the implant surface, particularly at the coronal bone. In the coronal portion of the DL group, a less mineralized bone area was observed compared to the IL group, suggesting higher bone remodeling activities.PLAIN LANGUAGE SUMMARYTitanium particles were widely present in bone tissues adjacent to the implant areas, with greater distribution observed in regions experiencing significant wear (i.e., the coronal portion of the cortical bone), likely due to surgical insertion and related procedures.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"14 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxacalcitol alleviates diabetes-associated periodontitis in male mice by restoring Treg/Th17 balance via SOCE-mediated mitochondrial dysfunction.","authors":"Xiaolin Li, Yujun Jiang, Minglei Zhang, Hongrui Liu, Minqi Li","doi":"10.1002/jper.70002","DOIUrl":"10.1002/jper.70002","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;CD4&lt;sup&gt;+&lt;/sup&gt; T lymphocytes play a central role in the pathogenesis of periodontitis, with the Treg/Th17 (regulatory T cell/T helper 17 cell) imbalance closely linked to diabetes-associated periodontitis (DPD). Maxacalcitol (OCT), an analog of active vitamin D, has therapeutic effects on diseases involving Treg/Th17 imbalance. This study aimed to determine whether OCT improved DPD by restoring the Treg/Th17 imbalance via store-operated Ca&lt;sup&gt;2+&lt;/sup&gt; entry (SOCE)-mediated mitochondrial dysfunction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The DPD model was established in male C57BL/6 mice and treated with local injections or oral administration of OCT. Microcomputed tomography and flow cytometry were used to assess the alveolar bone, Treg/Th17 balance, and SOCE. Flow cytometry and transmission electron microscopy were applied to detect Treg/Th17 balance and mitochondrial function.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;OCT attenuated alveolar bone loss and Treg/Th17 imbalance and enhanced the expressions of SOCE components in mice with DPD, with local injections showing more pronounced effects than oral administration. Furthermore, OCT restored the Treg/Th17 balance and improved mitochondrial dysfunction and overactivation of SOCE caused by lipopolysaccharides and high glucose. Additionally, SOCE inhibitors ameliorated mitochondrial abnormalities and Treg/Th17 imbalance under DPD conditions, whereas mitochondrial toxin and SOCE activators abolished the beneficial effects of OCT.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;OCT ameliorates Treg/Th17 imbalance via SOCE-mediated mitochondrial function, thereby effectively improving DPD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;Periodontitis, an inflammatory condition causing bone loss around teeth, is often more severe in individuals with diabetes due to immune system dysfunction. Specifically, diabetes-associated periodontitis (DPD) involves an imbalance between two types of immune cells: regulatory T cells (Treg), which control inflammation, and T helper 17 cells (Th17), which promote inflammation. This study explored how maxacalcitol (1α,25-dihydroxy-22-oxacalcitriol, OCT), a synthetic analog of active vitamin D3, treats DPD by correcting this immune cell imbalance. Using mouse models of DPD, we found that OCT significantly reduced bone loss and restored the balance between Treg and Th17 cells. Further investigation demonstrated that OCT functions by controlling calcium (Ca&lt;sup&gt;2&lt;/sup&gt;⁺) entry into cells, thereby preserving mitochondrial health. Blocking excessive Ca&lt;sup&gt;2&lt;/sup&gt;⁺ entry confirmed the improvement in immune cell balance. Conversely, increased Ca&lt;sup&gt;2&lt;/sup&gt;⁺ influx or disrupted mitochondrial function negated OCT's beneficial effects. Overall, OCT effectively ameliorates DPD by restoring the Treg/Th17 balance through alleviating store-operated Ca&lt;sup&gt;2+&lt;/sup&gt; entry (SOCE) overactivation-induced mitochondrial dysfunction, suggesting it could be a promising approach for","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three‐dimensional craniofacial morphology predicts periodontal tissue dimensions using the facial scanner","authors":"Kaijin Lin, Yongqing Guo, Minqian Zheng, Yue Tang, Jin Yang, Dong Wu, Jianbin Guo","doi":"10.1002/jper.70006","DOIUrl":"https://doi.org/10.1002/jper.70006","url":null,"abstract":"BackgroundDespite growing interest in dentofacial interactions, evidence linking three‐dimensional (3D) craniofacial morphology to periodontal phenotypes remains sparse. This cross‐sectional study aimed to investigate correlations between maxillary anterior periodontal parameters and 3D craniofacial morphology in a Chinese population.MethodsParticipants underwent cone‐beam computed tomography (CBCT) and intraoral scans to quantify bone thickness (BT) (at 2 mm [BT<jats:sub>1</jats:sub>] and 4 mm [BT<jats:sub>2</jats:sub>] apical to the alveolar crest), gingival thickness (GT) (at cemento‐enamel junction [GT<jats:sub>cej</jats:sub>] and bone crest [GT<jats:sub>bc</jats:sub>]), and periodontal supra‐crestal tissue height (PSTH). A 3D facial scanner measured vertical dimensions (facial height [FH], morphological facial height [MFH], nasal height [NH], lip height [LH]), and proportional indices (facial index [FI], morphological facial index [MFI], nasal index [NI], and lip index [LI]). Pearson correlations were performed to determine relationships between periodontal and craniofacial variables with Bonferroni correction for multiple comparisons (<jats:italic>α</jats:italic> = 0.05).ResultsA total of 96 adults (576 maxillary anterior teeth) participated in this study. NI, FH, MFH, and NH correlated positively with BT<jats:sub>1</jats:sub> (<jats:italic>r</jats:italic> &gt; 0.3, <jats:italic>p </jats:italic>&lt; 0.05) and BT<jats:sub>2</jats:sub> (<jats:italic>r</jats:italic> &gt; 0.3, <jats:italic>p </jats:italic>&lt; 0.05). Craniofacial indices (FI, MFI, and NI) exhibited significant positive associations with GT<jats:sub>cej</jats:sub> and GT<jats:sub>bc</jats:sub> (<jats:italic>r</jats:italic> &gt; 0.3, <jats:italic>p </jats:italic>&lt; 0.05), except lip‐related parameters. FI and MFI showed significant correlations with PSTH (<jats:italic>r</jats:italic> &gt; 0.3, <jats:italic>p </jats:italic>&lt; 0.05).ConclusionsBrachyfacial morphology and broader/shorter nasal dimensions were found associated with thinner gingiva, reduced alveolar bone, and lower PSTH in the maxillary anterior region. These findings highlight craniofacial morphology as a potential predictor of periodontal vulnerability.Plain Language SummaryPeople with shorter, broader facial structures tend to have thinner gum and bone tissues around teeth compared to those with longer, narrower faces, meaning their facial shape could help dentists predict and personalize treatments to avoid gum problems or implant issues.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"139 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of non‐surgical periodontal treatment on progranulin levels","authors":"Aysegul Sari, Pasquale Santamaria, Luigi Nibali","doi":"10.1002/jper.11396","DOIUrl":"https://doi.org/10.1002/jper.11396","url":null,"abstract":"BackgroundThe aim of this study was to study the effect of non‐surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) and serum progranulin (PGRN) levels in the early healing phases.MethodsThe study included periodontitis (test) (&lt;jats:italic&gt;n&lt;/jats:italic&gt; = 24) and periodontal health (control) (&lt;jats:italic&gt;n&lt;/jats:italic&gt; = 24) groups. PGRN, vascular endothelial growth factor (VEGF), interleukin (IL)‐1β, tumor necrosis factor alpha (TNF‐α), and IL‐10 levels were assessed at baseline, at the 1st, 2nd, and 14th day, and 1st and 3rd month after NSPT in serum and GCF samples by Luminex bead‐based multiplex immunoassay method.ResultsGCF PGRN, IL‐1β, TNF‐α, VEGF, and IL‐10 levels were higher in the test group than in the control group at baseline (&lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.05). GCF PGRN and VEGF levels decreased from day 14 after NSPT, while IL‐1β levels decreased gradually from day 2 (&lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.001). TNF‐α levels rapidly increased on day 1 after NSPT and gradually decreased from day 14 (&lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.001). GCF PGRN/ TNF‐α molar ratio levels dramatically decreased from baseline day 1 after treatment and then increased gradually from day 14 to the 1st month (&lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.001). There were no differences in serum parameters between groups and among time points (&lt;jats:italic&gt;p&lt;/jats:italic&gt; ≥ 0.05), while a strong positive correlation was detected between GCF PGRN and IL‐1β, and TNF‐α levels (&lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.001) at baseline.ConclusionsGCF PGRN total amount levels decreased gradually at each time point during the early healing period after NSPT, in parallel with IL‐1β. Changes in GCF PGRN and PGRN/TNF‐α molar ratio may be associated with periodontal disease and post‐treatment outcomes (ClinicalTrials.gov ID: NCT05535049).Plain language summaryProgranulin (PGRN) is a protein with complex physiological functions, producing granulin peptides that promote inflammatory and anti‐inflammatory activity. This study aimed to evaluate PGRN levels in the presence of periodontal disease and the local and systemic changes after following non‐surgical periodontal therapy (NSPT). The study included periodontitis (test) (&lt;jats:italic&gt;n&lt;/jats:italic&gt; = 24) and periodontal health (control) (&lt;jats:italic&gt;n&lt;/jats:italic&gt; = 24) groups. PGRN, vascular endothelial growth factor (VEGF), interleukin (IL) ‐1β, tumor necrosis factor alpha (TNF‐α), and IL‐10 levels were assessed in serum and gingival crevicular fluid (GCF) samples at baseline and at various time points after NSPT. GCF PGRN total amount levels were higher in the presence of periodontitis. Their levels decreased after NSPT from the 14th day in patients with periodontitis in parallel with inflammatory and regenerative mediators. However, PGRN/TNF‐α molar ratio levels increased after treatment at the end of the early healing phase. Molecular mediators hold promise as a diagnostic and therapeutic tool in","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"146 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity and random forest models of oral microbiomes in periodontal health using publicly available data","authors":"Alba Regueira‐Iglesias, Berta Suárez‐Rodríguez, Triana Blanco‐Pintos, Alba Sánchez‐Barco, Marta Relvas, Carlos Balsa‐Castro, Inmaculada Tomás","doi":"10.1002/jper.70000","DOIUrl":"https://doi.org/10.1002/jper.70000","url":null,"abstract":"BackgroundEvidence on the 16S metabarcoding of supragingival, subgingival, and salivary microbiomes in periodontal health remains limited. We aimed to analyze the diversity and potential of machine‐learning models of supragingival, subgingival, and salivary microbiomes in periodontal health.MethodsA total of 848 samples (supragingival = 210; subgingival = 155; saliva = 483) from 491 periodontally healthy subjects were included. Publicly available Illumina sequences were processed with mothur, and taxonomy was assigned using an oral‐specific database. Random forest (RF) models were built on the training set (2/3 of the samples) using a 3‐fold cross‐validation. They were tested on the test set (1/3).ResultsA total of 121 amplicon sequence variants (ASVs) presented with differential abundances between the two types of plaque, 212 between the supragingival and saliva samples, and 160 between the subgingival and saliva (&lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.01). Furthermore, the supragingival versus subgingival model consisted of five ASVs. The performance parameters on the test set were area under the curve (AUC) = 0.908, accuracy (ACC) = 84.30%, sensitivity = 95.71%, and specificity = 68.63%. Both the supragingival and subgingival versus saliva models also had five ASVs. These two models revealed similar performance (AUC = 0.992 and 0.986, ACC &gt; 95%, sensitivity &gt; 90%, specificity &gt; 95%).ConclusionAlthough supragingival and subgingival bacterial profiles diverged only modestly, primarily due to taxa with small effect sizes, they were both compositionally distinct from the salivary microbiome. RF models accurately classified samples by niche, with higher performance in distinguishing saliva from plaques. Specific ASVs from &lt;jats:italic&gt;Escherichia&lt;/jats:italic&gt;, &lt;jats:italic&gt;Fusobacterium&lt;/jats:italic&gt;, &lt;jats:italic&gt;Granulicatella&lt;/jats:italic&gt;, &lt;jats:italic&gt;Treponema&lt;/jats:italic&gt;, &lt;jats:italic&gt;Peptostreptococcaceae&lt;/jats:italic&gt; [XI][G‐9], and &lt;jats:italic&gt;Prevotella&lt;/jats:italic&gt; were identified in subgingival plaque, while &lt;jats:italic&gt;Oribacterium&lt;/jats:italic&gt; and &lt;jats:italic&gt;Solobacterium&lt;/jats:italic&gt; were identified in saliva, indicating potential niche‐specific microbial signatures in periodontal health.Plain Language SummaryMapping oral microbes in relation to periodontal health is essential for microbiome‐based diagnostics and the development of new preventive/therapeutic strategies. Our two‐by‐two predictive models demonstrated that a small set of bacterial ASVs can accurately classify periodontally healthy samples according to their oral niche. Notably, models distinguishing saliva from dental plaques achieved superior performance compared to those discriminating between plaques. This likely reflects the greater resemblance in dominant microbial taxa between the two plaque niches. These findings underscore the potential of machine‐learning approaches to identify key microbial signatures and highlight the predictive ASVs as promi","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"9 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balint Orban Memorial Program Abstracts","authors":"","doi":"10.1002/jper.25-0080","DOIUrl":"https://doi.org/10.1002/jper.25-0080","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"70 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of disrupted circadian rhythms with self‐reported periodontal diseases: Insights from 94,305 UK biobank participants","authors":"Dongyun Wang, Yanling Wei, Qi Xiang, Hongyu Yang, Ying Shan","doi":"10.1002/jper.11388","DOIUrl":"https://doi.org/10.1002/jper.11388","url":null,"abstract":"BackgroundThis study investigates the association of circadian rhythmicity, physical activity, and chronotype with periodontal diseases, focusing on both the independent and combined effects.MethodsA cross‐sectional study was conducted among 94,305 participants from the UK Biobank. Circadian rhythmicity, measured by relative amplitude from the accelerometer, was the primary exposure, with physical activity and chronotype (morning/evening preference) as secondary exposures. Self‐reported periodontal diseases were the outcome of interest. Multivariable logistic regression and restricted cubic splines were used to evaluate linear and nonlinear associations, including interactions between exposures.ResultsEach standard deviation increase in relative amplitude was associated with a 3% lower risk of periodontal diseases (odds ratio, OR: 0.97, 95% confidence interval, CI: 0.95–0.99). A 10 milligravity increase in physical activity was associated with a 10% reduction in risk (OR: 0.90, 95% CI: 0.87–0.92). An evening chronotype increased the risk by 23% (OR: 1.23, 95% CI: 1.15–1.32). Both additive and multiplicative interactions were observed between physical activity and chronotype, as evidenced by the relative excess risk due to interaction (RERI) and attributable proportion (AP), with confidence intervals excluded the null, and a synergistic effect on the multiplicative scale (OR: 1.13, 95% CI: 1.03–1.24). A nonlinear association between physical activity and periodontal diseases was observed.ConclusionsDisrupted circadian rhythms, lower physical activity, and an evening chronotype are independently and interactively associated with an elevated risk of periodontal disease. Interventions promoting circadian alignment and increasing physical activity may represent promising strategies to explore in future studies aiming to reduce periodontal risk.Plain Language SummaryModern life, with long hours and shift work, can disrupt our natural daily body clocks. This study looked at whether these disrupted rhythms, along with how much we move and whether we are “morning people” or “night owls”, affect oral health. Using wearable devices worn by over 94,000 UK adults, researchers found that people with smaller differences in activity between their most active and least active times of day had a higher risk of periodontal disease. Being more physically active was strongly associated with a lower risk, while people who naturally preferred being active later in the day (“night owls”) had a higher risk. Importantly, the combination of being a “night owl” and having low physical activity posed the greatest risk, higher than just adding the two risks together. This suggests that keeping a regular daily activity pattern (being more active during the day and less at night), getting enough exercise, and perhaps trying to lean towards a morning routine could all be important ways to maintain oral health. While more research is needed, especially to see if changing these ha","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"50 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volume‐stable collagen matrix to treat gingival recession associated with non‐carious cervical lesions: Randomized clinical trial","authors":"Mauro Pedrine Santamaria, Manuela Maria Viana Miguel, Amanda Rossato, Ana Carolina Ferreira Bonafé, Isabel Vasconcellos de Souza, Thiago Marchi Martins, Marcelo Pereira Nunes, Ingrid Fernandes Mathias‐Santamaria","doi":"10.1002/jper.11386","DOIUrl":"https://doi.org/10.1002/jper.11386","url":null,"abstract":"BackgroundCollagen matrices (CMs) have been used for the treatment of gingival recession defects. A new volume‐stable collagen matrix (VCMX) was developed focused on enhancing tissue thickness due to a cross‐linked collagen structure. Thus, the present randomized clinical trial aims to evaluate clinical and patient‐centered parameters in the treatment of gingival recession (GR) RT1 associated with non‐carious cervical lesions (NCCL) B+ partially restored using coronally advanced flap (CAF) alone or CAF and VCMX.MethodsForty patients diagnosed with GR RT1 plus NCCL B+ were treated with partial restorations (composite apical margin 1 mm beyond the estimated level cement–enamel junction), followed by CAF alone or with VCMX. Clinical, patient‐related outcomes and esthetic measurements were assessed after 6 months. The recession reduction (RecRed) was the primary outcome.ResultsCAF and CAF+VCMX provided significant RecRed (1.87 vs. 1.78 mm; <jats:italic>p</jats:italic> = 0.76) and combined defect coverage (%CDC: 50.95 vs. 48.64%, <jats:italic>p</jats:italic> = 0.60) after 6 months. No difference was observed regarding the estimated root coverage (73.54 vs. 69.65%, <jats:italic>p</jats:italic> = 0.75). Greater gingival thickness (GT) gain was observed with VCMX (0.43 vs. 0.15 mm, <jats:italic>p</jats:italic> = 0.003). Both treatments decreased dentin hypersensitivity, achieved aesthetic satisfaction, and provided similar patient comfort. Keratinized tissue width is an important predictor for root coverage success while VCMX depends on it for greater RecRed (β = 1.775; <jats:italic>p</jats:italic> = 0.004). Combined defect (CD) height and depth can have both positive and negative impacts on coverage parameters.ConclusionsBoth therapies provided significant CD coverage and RecRed, with no superiority of CAF+VCMX over CAF. However, VCMX led to a higher GT gain after 6 months (NCT05916716; IRB:46852621.0.0000.0077).Plain Language SummaryCombined defects (CDs), where gingival recession (GR) is associated with non‐carious cervical lesions (NCCL), represent a clinical condition that clinicians frequently encounter. The lack of treatment worsens dentin hypersensitivity (DH) and esthetic perceptions. Some CDs require a surgical‐restorative protocol. To date, partial restorative fillings combined with a coronally advanced flap (CAF), and connective tissue graft (CTG) surgical technique is considered the most predictable approach; however, the use of CTG has some drawbacks, including the risk of bleeding and patient discomfort. The use of collagen matrices (CMs) as an alternative to CTG has been assessed in the literature. This study aimed to evaluate a cross‐linked collagen matrix (VCMX) in the treatment of GR/RT1 associated with NCCL/B+ partially restored. Despite similar recession reduction and combined defect coverage of up to 6 months, the VCMX promoted a greater increase in gingival thickness (GT) (0.43 mm). This is a crucial parameter for maintaining long‐","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"49 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between periodontal parameters and thyroid markers in autoimmune hypothyroidism: A cross‐sectional study","authors":"Sunitha Puthiyapurayil, Rosamma Joseph Vadakkekuttical, Thulaseedharan Nallaveettil Kesavan, Harikumar Kanakkath","doi":"10.1002/jper.24-0735","DOIUrl":"https://doi.org/10.1002/jper.24-0735","url":null,"abstract":"BackgroundInflammatory cytokines play a significant role in the pathogenesis of both autoimmune hypothyroidism and periodontal disease. The cumulative effect of these inflammatory markers may lead to extensive periodontal breakdown. This study was undertaken to assess the prevalence and severity of periodontitis, to correlate clinical attachment loss (CAL), and periodontal inflamed surface area (PISA) with anti‐thyroid peroxidase (anti‐TPO) antibody, triiodothyronine (T3), thyroxine (T4), thyroid‐ stimulating hormone (TSH), and C‐reactive protein (CRP) in autoimmune hypothyroid patients and systemically healthy subjects.MethodsThis cross‐sectional study comprised of 65 autoimmune hypothyroid patients under treatment and 75 systemically healthy subjects. All participants were evaluated for periodontal parameters (bleeding on probing (BoP), probing pocket depth (PPD), CAL, oral hygiene index‐simplified (OHI‐S Index), Plaque Index (PI) and PISA) and systemic parameters (T3, T4, TSH, anti‐TPO antibody, and CRP). Analysis of quantitative and qualitative data was done by unpaired <jats:italic>t</jats:italic>‐test and Chi‐Square test, respectively.ResultsPrevalence and severity of periodontitis in the autoimmune hypothyroid group were significantly higher compared with the systemically healthy group (<jats:italic>p</jats:italic> &lt; 0.001). CAL, PISA, T3, TSH, and anti‐TPO antibody were significantly higher in the autoimmune hypothyroid group as compared with the systemically healthy group. Mean CAL and PISA were positively correlated with anti‐TPO antibody, T3, T4, TSH, and CRP. The multivariate linear regression model with dependent variable mean CAL showed that anti‐TPO antibody was significantly associated with mean CAL (<jats:italic>β</jats:italic> = 0.001, <jats:italic>p </jats:italic>= 0.02).ConclusionsAutoimmune hypothyroid subjects exhibited a higher prevalence and severity of periodontitis compared with the systemically healthy group. BoP, PPD, CAL and PISA were also higher in autoimmune hypothyroid group as compared with the systemically healthy group. A statistically significant positive correlation of CAL, and PISA with anti‐TPO antibody, T3, TSH, and CRP was observed.Plain language summaryThis study assessed the link between autoimmune hypothyroidism (a condition characterized by decreased thyroid function) and periodontitis by comparing 65 individuals with autoimmune hypothyroidism undergoing treatment to 75 healthy subjects. This research measured periodontal health indicators, thyroid hormone levels, and inflammatory markers. Results indicated that those with autoimmune hypothyroidism experienced more severe periodontal disease and increased periodontal tissue loss. They also showed elevated levels of specific thyroid antibodies and thyroid hormonal imbalances. Importantly, a significant positive association was found between the extent of periodontal tissue loss and these thyroid‐related markers, especially the anti‐TPO antibody. In c","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"20 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}