Journal of periodontology最新文献

{"title":"Use of cells and/or biologics combined with scaffolds in alveolar bone augmentation for implant site development","authors":"Alberto Monje, Maria Costanza Soldini, Farahnaz Fahimipour, Manal Sarsri, Maria L. Geisinger","doi":"10.1002/jper.70105","DOIUrl":"https://doi.org/10.1002/jper.70105","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The impact of adjunctive biologics and the use of cell-therapy has been sparsely explored. The objective of this systematic review is to evaluate the effectiveness/efficacy of these therapeutic modalities combined with scaffolds in alveolar bone augmentation for implant site development.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An electronic and manual was conducted. Clinical trials evaluating the effectiveness/efficacy and safety of biologics and cell-therapy combined with scaffolds used for bone alveolar augmentation procedures aiming at implant site development were eligible. The primary outcome was to assess the dimensional bone changes/gain, while the and secondary outcomes included histologic outcomes, patient-reported outcomes, complications and adverse effects. Meta-analysis was conducted only based on randomized clinical trials (RCTs). Moreover, risk of bias assessment of the selected investigations was also reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, after screening, 68 articles were eligible for qualitative synthesis. Of these, 56 were selected of which 23 RCTs (n<sub>patients </sub>= 1078) were included in a quantitative analysis. In particular, six articles (n<sub>patients </sub>= 172) for lateral ridge augmentation, nine articles (n<sub>patients </sub>= 455) for alveolar ridge preservation, and eight articles (n<sub>patients </sub>= 451) for sinus floor elevation. All 23 RCTs explored the effectiveness/efficacy of adjunctive biologics. For ridge augmentation, the use of biologics resulted in superior outcomes in ridge width (RW) gain, especially the use of platelet rich plasma (<i>p</i> < 0.001), but not in ridge height (RH). For ridge preservation procedures, the adjunctive use of biologics rendered an added therapeutic benefit to maintain ridge dimensions, especially the use of bone morphogenetic protein-2 for RW (<i>p</i> = 0.02) and RH (<i>p</i> = 0.09). Less non-mineralized tissue was found based on histologic analysis for the use of biologics compared to control groups (<i>p</i> = 0.009). For sinus floor elevation, no benefit was shown in terms of RH gain (<i>p</i> = 0.87). However, upon histomorphometric analysis statistically less residual graft material was noted when biologics were used in combination with scaffolds (<i>p</i> < 0.001) compared to treatments without biologics. No complications or adverse events were found when using biologics or cell-therapy in these applications. Use of the assessed adjunctive biologics generally did not have an influence on patient-reported outcomes. Low risk of bias was demonstrated in the included studies.</p>\u0000 ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 S1","pages":"S70-S88"},"PeriodicalIF":4.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AAP/OF/SEPA workshop on new technologies in oral reconstructive medicine","authors":"Effie Ioannidou","doi":"10.1002/jper.70170","DOIUrl":"https://doi.org/10.1002/jper.70170","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 S1","pages":"S5-S7"},"PeriodicalIF":4.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autogenous grafts versus substitute scaffolds for soft tissue augmentation in implant therapy: A systematic review","authors":"Gustavo Avila-Ortiz,&nbsp;Sandra Stuhr,&nbsp;Miha Pirc,&nbsp;Emilio Couso-Queiruga,&nbsp;Franz J. Strauss,&nbsp;Leandro Chambrone,&nbsp;Daniel Thoma,&nbsp;Ronald Jung","doi":"10.1002/jper.70104","DOIUrl":"https://doi.org/10.1002/jper.70104","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To analyze the effect of autogenous soft tissue grafts or substitute scaffolds on the outcomes of soft tissue augmentation (STA) performed in the context of implant therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The protocol of this PRISMA 2020-compliant systematic review was registered in PROSPERO (CRD42024611477). Articles reporting the findings of randomized controlled trials (RCTs) that met the eligibility criteria were identified through a literature search. Following final article selection, data were extracted, including relevant clinician- and patient-reported outcomes and experiences (CROs and PROs/PREs). Risk of bias assessment was performed using the RoB2 tool. Network meta-analyses (NMA) were performed when feasible to compare the performance of different techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty RCTs were selected. Risk of bias assessment revealed that the methodological quality of the selected studies was generally high. Although CROs and PROs/PREs were inconsistently reported, it was possible to conduct five sets of NMA regarding mucosal thickness (MT) and keratinized mucosa width (KMW) changes. These analyses revealed that the use of an autogenous connective tissue graft in a bilaminar approach is the best treatment for MT augmentation regardless of the timing, while the application of a free mucosal graft over a partial-thickness vascular bed is generally the best to obtain KMW gains. Alternatively, other treatment options involving the use of specific types of substitute scaffolds were considered as viable alternatives given their similar performance, particularly in terms of MT gain. Additionally, it was found that, compared with autogenous soft tissue grafts, the use of substitute scaffolds is consistently associated with lower postoperative discomfort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Autogenous soft tissue grafts should be considered as the primary choice to achieve predictable MT and KMW gains in the context of implant therapy. The use of specific substitute scaffolds may render similar STA outcomes with lower postoperative morbidity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 S1","pages":"S52-S69"},"PeriodicalIF":4.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of engineered scaffolds for horizontal and vertical ridge augmentation: A systematic review and meta-analysis","authors":"Muhammad H. A. Saleh,&nbsp;Elena Calciolari,&nbsp;Ethan Ng,&nbsp;Sandra Stuhr,&nbsp;Hamoun Sabri,&nbsp;Nikolaos Donos,&nbsp;Purnima S. Kumar","doi":"10.1002/jper.70103","DOIUrl":"https://doi.org/10.1002/jper.70103","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Engineered scaffolds hold promise for personalizing surgical therapy and are being increasingly applied in clinical practice. Therefore, a comprehensive synthesis of existing data on ridge augmentation is warranted.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A systematic review and meta-analysis were conducted following PRISMA guidelines (PROSPERO: CRD42024611887). Four databases (MEDLINE, EMBASE, Cochrane Central, Scopus) and the grey literature were searched. Eligible studies included randomized clinical trials and prospective case series. The primary outcomes were horizontal, vertical, and volumetric bone gains. A meta-analysis was performed to obtain pooled estimates for vertical bone gain (mm), horizontal bone gain (mm), volumetric bone gain (mm&lt;sup&gt;3&lt;/sup&gt;), and early and late complication rates (%). The certainty of evidence was evaluated using the GRADE approach.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Thirteen studies (&lt;i&gt;n&lt;/i&gt; = 241 patients, mean age 47.1 years) and 202 defects (12.4% horizontal, 27.2% vertical, and 60.4% combined) were included. Risk of bias was significant, with three of six randomized clinical trials showing low risk and all non-randomized studies showing moderate-to-serious risk of bias. Nine studies used customized computer-aided design and manufacturing (CAD/CAM) titanium mesh devices, while the remaining studies used materials like polyether ether-ketone scaffolds (two studies), three-dimensional hydroxyapatite blocks (one study), or customized allogeneic bone blocks (one study). Pooled horizontal bone gain was 4.96 mm (95% CI: 4.48–5.44 mm), vertical gain 5.64 mm (95% CI: 5.26–6.02 mm), and volumetric gain 1307 mm&lt;sup&gt;3&lt;/sup&gt; (95% CI: 1000–1700 mm&lt;sup&gt;3&lt;/sup&gt;) over a 6 to 9-month follow-up period. The overall complication rate, irrespective of timing and resorbable membrane use, was 21.7% [16.4–27.0]. The pooled early and late (&lt;4 or ≥4 weeks) complication rates were 24.3% and 16.5%, respectively. Based on six studies, the early complications were 25.6% without versus 21.4% with resorbable membranes. Meta-regression identified smoking status, surgical experience of the operator, and the defect type as significant factors influencing bone gain.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Engineered scaffolds show promise in managing complex alveolar defects, achieving significant bone gains in all dimensions. However, a high complication rate makes the outcomes unpredictable and limits their use to selective cases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 S1","pages":"S33-S51"},"PeriodicalIF":4.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of cells and/or biologics combined with scaffolds for soft tissue regeneration around dental implants","authors":"Eduardo Montero,&nbsp;Zhaozhao Chen,&nbsp;Nerea Sánchez,&nbsp;Javier Sanz Esporrin,&nbsp;Hom-Lay Wang,&nbsp;George A. Mandelaris","doi":"10.1002/jper.70107","DOIUrl":"https://doi.org/10.1002/jper.70107","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this systematic review is to evaluate the efficacy of cell-based therapies and biologically enhanced scaffolds for peri-implant soft tissue regeneration, including the increase in soft tissue thickness (STT) and/or keratinized mucosa (KM) augmentation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic literature search was conducted in Ovid MEDLINE, EMBASE, and Dentistry and Oral Sciences Source until August 2025. A focused question was developed: “In patients with soft tissue defects requiring soft tissue augmentation procedures prior to, at the time of implant placement or after it, what is the efficacy of combining cell therapy and/or biological treatments with a soft tissue scaffold compared to the use a soft tissue scaffold without cells and/or biologics, or no scaffold, on the increase of STT and/or KM in clinical trials or prospective case series?”. Post-operative morbidity, interproximal bone level changes, clinical peri-implant outcomes or patient-reported outcome measures (PROMs) were collected. Risk of bias was assessed using RoB 2.0, ROBINS-I and the National Institutes of Health (NIH) Study Quality Assessment Tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ten publications were included (six randomized clinical trials [RCTs] and four prospective case series). The use of free gingival grafts (FGGs) lead to significantly greater KM augmentation when compared with platelet-rich fibrin (PRF) membranes (weighted mean difference [WMD] = −2.0; 95% confidence interval [CI]: −3.3, −0.8; <i>p</i> &lt; 0.001) although PRF membranes significantly increased the amount of KM when compared to no scaffold/graft (<i>n</i> = 2; WMD = 1.1 mm; 95% CI: 0.2, 2.1; <i>p</i> = 0.017) and seem to increase also STT. Available data on other biologics (e.g., recombinant human platelet-derived growth factor BB [rhPDGF-BB]) are scarce. No studies evaluating cell therapies were identified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PRF membranes are effective in increasing the KM and STT around dental implants, even if KM augmentation by means of autogenous grafts lead to superior outcomes. There is a lack of evidence on cell-based therapies or other biologics for their use in soft tissue regeneration around dental implants.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 S1","pages":"S89-S102"},"PeriodicalIF":4.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging, personalized, and minimally invasive technologies for periodontal and peri-implant soft and hard tissue regenerative therapy","authors":"Shayan Barootchi,&nbsp;Lorenzo Tavelli,&nbsp;Hamoun Sabri,&nbsp;William V. Giannobile,&nbsp;Darnell Kaigler","doi":"10.1002/jper.70108","DOIUrl":"https://doi.org/10.1002/jper.70108","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Regenerative therapies have become central to periodontics and implant dentistry and are becoming more widely applied to reconstruct supporting bone and associated soft tissues. With increased recognition of the benefits of using biomimetic materials as scaffolds in contemporary regenerative technologies, the field is seeking to develop and optimize predictable, personalized regenerative strategies for hard and soft tissue reconstruction. This review aims to: (1) evaluate the current evidence on these approaches in the context of hard and soft tissue deficiencies around teeth and implants, (2) assess the clinical utility of these approaches, and (3) propose a framework for integrating these regenerative technologies into daily clinical practice.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Applicable research on the treatment of hard and /or soft tissue deficiencies around teeth and dental implants were conducted. For soft tissue regeneration, data from eligible randomized clinical trials (RCTs) reporting the outcomes of gingival (for teeth, as gingival thickness [GT]) and mucosal thickness (implants, MT) with a bilaminar approach were analyzed using a mixed models network meta-analysis. A meta-analysis could not be performed to evaluate personalized, emerging technologies for bone regeneration given the lack of comparable clinical studies and as such, an alternative evaluative approach was undertaken and involved a qualitative assessment of the relevant literature highlighting innovations in these emerging modalities.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 78 RCTs were included for a quantitative analysis on soft tissue regeneration. Fifty-four reported the outcomes of GT with a bilaminar approach (a total of 2952 teeth), and 24 assessed MT around implants (851 implants). The analysis of GT for natural dentition showed that bilaminar approaches with any of the explored soft tissue grafts (connective tissue graft (CTG), human acellular dermal matrix (hADM), first generation collagen matrix (CMX), “volume stable” collagen matrix (VCMX) yield a statistically significant increase in GT (compared with untreated sites), with the highest estimate for CTG, followed by VCMX, hADM, pADM, and CMX. Similarly, the analysis of MT around implants also showed a significant increase for all the investigated treatment groups, compared with untreated sites. No other significant differences were noted among the other treatment groups of (VCMX, hADM, and pADM).&lt;/p&gt;\u0000 \u0000 &lt;p&gt;For the qualitative assessment of emerging technologies for bone regeneration, early investigational studies have","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 S1","pages":"S103-S139"},"PeriodicalIF":4.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of leaving periodontal disease untreated on healthcare expenditures: A retrospective cohort study","authors":"Anna Kinugawa,&nbsp;Kenji Takeuchi,&nbsp;Yudai Tamada,&nbsp;Taro Kusama,&nbsp;Futoshi Oda,&nbsp;Megumi Maeda,&nbsp;Hiroe Ohyama,&nbsp;Ken Osaka,&nbsp;Haruhisa Fukuda","doi":"10.1002/jper.70136","DOIUrl":"10.1002/jper.70136","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aimed to investigate whether healthcare expenditures (HCEs) differed depending on whether the patients left periodontal disease (PD) untreated, despite the need for treatment.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study used public PD screening data from a municipality in Japan to identify adults aged ≥ 40 years who were found to require treatment of PD by dentists at PD screening. The presence or absence of periodontal treatment was determined by a dental visit within 180 days after the date of PD screening based on medical claims data. Annual HCE were calculated from cumulative expenditures over 2 years from the date of the presence or absence of periodontal treatment. A generalized linear model with a gamma distribution and log link function was used to calculate the relative cost ratios (RCRs) and 95% confidence intervals (95% CI), and a two-part model was used to predict annual HCEs and the difference in predicted HCEs based on dental treatment.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Among 652 people (mean age: 62.6 years [1 SD = 9.0], 65.5% women), 9.0% were untreated. After adjusting for the covariates, the RCR for medical, pharmaceutical, and dental costs in the untreated group compared with the treated group were 1.56 (95% CI: 1.02–2.38), 0.95 (95% CI: 0.53–1.70), and 0.14 (95% CI: 0.10–0.19), respectively. The differences in predicted HCEs were $593.5 (95% CI: –280.6, 1467.6) higher for medical, $79.9 (95% CI: –363.6, 523.4) higher for pharmaceutical, and $323.9 (95% CI: –397.3, –250.6) lower for dental.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Leaving PD untreated was associated with increased HCEs, particularly medical expenditures.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study looked at whether people who were told by a dentist that they needed care for periodontal disease actually received treatment, and how this affected their healthcare costs. The research followed more than 600 adults in Japan for 2 years, comparing the cumulative healthcare costs of those who received dental care with those who did not. The results showed that people who did not treat their periodontal disease ended up spending more on medical care, even though they spent less on dental care. On average, untreated individuals had medical expenses that were around $600 higher than those who received treatment. This suggests that avoiding dental care for periodon","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"2003-2012"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147708505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are the detection and dimensions of peri-implant buccal bone defects influenced by different implant materials and their location? An experimental cone-beam computed tomography study","authors":"Yulan Wang,&nbsp;Matheus L. Oliveira,&nbsp;Dorothea Dagassan-Berndt,&nbsp;Michelle Simonek,&nbsp;Sebastian Kühl,&nbsp;Michael M. Bornstein","doi":"10.1002/jper.70076","DOIUrl":"10.1002/jper.70076","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The aim of this study is to evaluate the impact of different implant materials and arrangements within the field of view (FOV) and exomass on the diagnostic accuracy and image quality of cone-beam computed tomography (CBCT) for the detection of peri-implant buccal bone defects of various sizes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 120 CBCT scans with three different implant materials with identical diameter (titanium [Ti], titanium-zirconium [TiZr], and zirconium dioxide [ZrO&lt;sub&gt;2&lt;/sub&gt;]) and three surgically created peri-implant defect sizes (no defect, small defect: 3 mm, large defect: 6 mm) using two CBCT scanners (X800 and Planmeca) were generated. Three independent examiners assessed the scans for the presence of peri-implant bone defects, rated the impact of metal artefacts on diagnostic confidence (visual analog scale [VAS] 0–10), and measured the maximum height and width of the defect, when present. Diagnostic performance (sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve) was calculated by a generalized linear mixed model. Artefact perception (VAS) and measurement error (height and width) were analyzed using analysis of variance, with &lt;i&gt;p&lt;/i&gt; &lt; 0.05 considered significant.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;CBCT imaging demonstrated high overall diagnostic accuracy for detecting surgically created peri-implant bone defects when implants were positioned within FOV and the exomass. Nevertheless, defect size (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) and implant material (&lt;i&gt;p&lt;/i&gt; = 0.019) did affect the diagnostic accuracy significantly. Smaller bone defects (79.4%) were associated with a reduced diagnostic accuracy compared with larger defects (99.1%) and non-defect sites (95.3%). ZrO&lt;sub&gt;2&lt;/sub&gt; dental implants (85.4%) were associated with a reduced diagnostic accuracy compared with Ti (97.5%) and TiZr implants (92.6%).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;CBCT reliably detects peri-implant bone defects, irrespective of the implant material or the presence in the exomass. While ZrO&lt;sub&gt;2&lt;/sub&gt; implants and smaller defects can reduce diagnostic accuracy, its overall performance remains robust, warranting further clinical validation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study explored how well cone-beam computed tomography (CBCT), a 3D dental imaging technique, can detect bone loss around dental implan","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1860-1870"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cisplatin and tamoxifen chemotherapy on peri-implant bone remodeling around titanium implants in ovariectomized rats: An in vivo study","authors":"Luiz G. Fiorin,&nbsp;Henrique Rinaldi Matheus,&nbsp;Gabriela Carrara Simionato,&nbsp;Ester Oliveira Santos,&nbsp;Ruan Delmonica Barra,&nbsp;Francisley Avila Souza,&nbsp;Edilson Ervolino,&nbsp;Claudia Dellavia,&nbsp;Juliano M. de Almeida","doi":"10.1002/jper.70096","DOIUrl":"10.1002/jper.70096","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The proposition of the present study was to evaluate the influence of the secondary effect of tamoxifen (TAM) associated with cisplatin (CIS) in the bone remodeling of osseointegrated titanium implants installed in rat tibiae.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;One hundred female rats underwent bilateral ovariectomy (OVX) and received titanium implants in both tibiae. Six weeks later, animals were treated with tamoxifen (15 mg/kg) or saline, with further subdivisions receiving cisplatin (5 mg/kg or 2.5 mg/kg) or saline. A non-ovariectomized group served as a negative control. Animals were euthanized at 30 and 90 days after treatment initiation. Tibiae were harvested for histometric analysis of bone-to-implant contact (BIC) and bone ingrowth (BIN), histology, and immunohistochemistry (tartrate-resistant acid phosphatase [TRAP], osteocalcin [OCN], and runt-related transcription factor [RUNX2]). Additionally, scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) were used for ultrastructural and elemental analyses.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The groups that received TAM showed higher BIC and BIN, increased expression of RUNX-2 and OCN, and a lower number of TRAP-positive cells. At 30 and 90 days, almost all spaces were filled with vital, well-vascularized bone tissue without inflammatory foci. TAM groups also exhibited an increased calcium/phosphate (Ca/P) ratio compared to their respective controls, and a progressive thickening of collagen fibril bundles was observed in the bone matrix.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Tamoxifen positively influenced bone remodeling around osseointegrated titanium implants in rats undergoing cisplatin-based cancer therapy.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Dental implant surgery in patients undergoing chemotherapy is frequently approached with caution, as these pharmacological treatments can impair bone metabolism and jeopardize the integration of the implant with the bone. This study investigated whether tamoxifen, a medication widely utilized in breast cancer therapy, could potentially enhance bone healing around titanium implants, specifically when administered alongside the chemotherapeutic agent cisplatin. Utilizing a laboratory model that simulates postmenopausal bone loss, the research demonstrated that tamoxifen significantly improved both the volume and the structural quality of the bone surrounding the implants, partially mitigating the adverse effects associated with cis","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1949-1964"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between periodontitis and oral health–related quality of life in patients with systemic conditions: A meta-analysis","authors":"Rafael Vargas Bortolaso,&nbsp;Catiusse Crestani Del' Agnese,&nbsp;Leandro Machado Oliveira,&nbsp;Patricia A. Miguez,&nbsp;Fabricio Batistin Zanatta,&nbsp;Raquel Pippi Antoniazzi","doi":"10.1002/jper.70130","DOIUrl":"10.1002/jper.70130","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The objective of this systematic review is to evaluate whether periodontitis is associated with impaired oral health–related quality of life (OHRQoL) in adults with systemic conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Five databases were searched to identify observational studies that tested the association between periodontitis (diagnosed by clinical periodontal examination) and OHRQoL (validated instrument). Random-effects models were applied in the meta-analyses, and the Newcastle-Ottawa Scale (NOS) was used for quality assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventeen studies were included, with 94.1% using the OHIP-14 instrument. Only one study was rated as high quality. Meta-analysis showed a small and significant association between periodontitis and impaired OHRQoL (SMD: 0.31; 95% CI: 0.03–0.59). Individuals with periodontitis had higher OHIP-14 scores than the comparison group (MD: 2.29; 95% CI: 0.24–4.33). Studies using the 2017 periodontitis classification yielded significantly higher estimates than those using earlier criteria. Furthermore, a strong negative impact of periodontitis on OHRQoL was observed among individuals with psoriasis, whereas no significant association was identified for other systemic conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Periodontitis has a small negative impact on OHRQoL in patients with comorbidities. The type of systemic condition and the periodontitis diagnostic criteria influence this association.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>Periodontitis negatively impacts oral health–related quality of life across different populations. However, this impact may appear smaller in individuals with certain systemic conditions, as additional health challenges can overshadow the perceived effects of periodontitis on daily life. Our systematic review found a small negative impairment of OHRQoL associated with periodontitis in patients with comorbidities, with the magnitude of this association influenced by the type of systemic condition and the diagnostic criteria used to define periodontitis. Further high-quality studies are needed to strengthen the current evidence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1990-2002"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147708516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}