Journal of periodontology最新文献

{"title":"Multiscale, interspecies evaluation of parameters affecting alveolar bone repair.","authors":"Pavla Ticha,Arush Joshi,Julia S Dworan,Marzia Armaro,Masaki Arioka,Quanchen Xu,Igor Pilawski,Yindong Liu,Chih-Hao Chen,Xibo Pei,Ustun Serdar Tulu,Hannes Traxler,Yasemin Erdogan,Jill A Helms","doi":"10.1002/jper.24-0594","DOIUrl":"https://doi.org/10.1002/jper.24-0594","url":null,"abstract":"BACKGROUNDWe undertook a comparative analysis of bone healing in the craniomaxillofacial (CMF) skeleton, focusing on the extent to which the physiological processes of bone repair and remodeling differed between different species. Understanding these differences can enhance the value of research outputs and thus improve treatment strategies.METHODSAn osteotomy was produced in an equivalent anatomical location in mice, rats, minipigs, and human patients. Quantitative analyses were performed using micro-computed tomographic (µCT) imaging, histology, dynamic histomorphometry, immunohistochemistry, and cellular activity assays.RESULTSNon-invasive imaging analyses, histomorphometry, and molecular and cellular analyses together demonstrated that the overall bone repair program was highly conserved between rodents and minipigs, correlating with limited human data. Comparing the rate of bone repair across species was confounded by limited time points for analysis in human tissues. However, at later time points, CMF bone repair in minipigs was equivalent to CMF bone repair in rodents.CONCLUSIONSThe molecular and cellular features of bone repair are shared among large and small animals, suggesting a common bone healing mechanism among species. Combined with the availability of transgenic lines and an extensive array of molecular and cellular analyses, this makes rodents an appealing choice for preclinical testing.PLAIN LANGUAGE SUMMARYWe conducted this study to understand how bone heals in the head skeleton. We compared this repair process in animal models, including mice, rats, and minipigs, against a limited set of data from humans. Our goal was to determine whether bone repair and remodeling were conserved between species because this would have implications for preclinical studies to improve treatment strategies. We created a controlled injury in similar bone areas in each species, then examined the healing process using various research techniques, analyzing bone architecture and cellular activity. Our findings showed that the overall process of bone healing was similar between species. Although we had limited data from humans at later stages of healing, the healing patterns in minipigs closely matched those in rodents at the later stages. These similarities suggest that the way bones heal is equivalent among mammals. Therefore, with the added advantage of advanced research techniques available, rodents are an excellent choice for testing new treatments before advancing to studies in large animals and testing in humans.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"47 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of horizontal platelet‐rich fibrin on gingival tissue regeneration: Cellular and histological analysis","authors":"Jihua Chai, Yulu Chen, Shan Shi, Zaibo Yang, Sensen Li, Richard J. Miron, Yulan Wang, Yufeng Zhang","doi":"10.1002/jper.11364","DOIUrl":"https://doi.org/10.1002/jper.11364","url":null,"abstract":"BackgroundHorizontal platelet‐rich fibrin (H‐PRF) is a novel platelet concentrate known for promoting tissue regeneration, the purpose of this study was to assess the impact of H‐PRF on gingival defects healing using both in vitro and in vivo approaches.MethodsHuman gingival fibroblasts (hGFs) were cultured with lipopolysaccharide (LPS), H‐PRF, and H‐PRF + LPS. Then, cell viability, proliferation, apoptosis and migration were evaluated via fluorescence staining, CCK‐8, flow cytometry, scratch and Transwell assays, respectively. Gingival defects were created in a rabbit model and treated with or without H‐PRF membranes. Tissue remodeling was evaluated at 14 and 21 days post‐surgery using hematoxylin and eosin (H&E) staining, Masson's trichrome staining, and immunohistochemistry (IHC) for E‐cadherin, and neovascularization was evaluated by IHC for CD31.ResultsH‐PRF promoted hGFs proliferation and migration and mitigated the negative effects of LPS on hGF viability and apoptosis. In animal model, H‐PRF significantly accelerated gingival defect closure, reduced pseudomembrane formation, and promoted the formation of a thicker, stratified squamous epithelium with rete peg formation by day 21. Compared with untreated defects, H‐PRF‐treated defects exhibited significantly increased collagen deposition and elevated expression of E‐cadherin. Moreover, enhanced neovascularization was observed in the H‐PRF group, as evidenced by the increased expression of CD31‐positive cells.ConclusionH‐PRF significantly improved gingival defects healing by enhancing hGF cellular behaviors and promoting epithelialization and neovascularization. These findings support the potential of H‐PRF as an effective adjunctive therapy during gingival tissue regeneration.Plain Language SummaryHorizontal platelet‐rich fibrin (H‐PRF) is a platelet concentrate derived from patient's own blood that has gained momentum in regenerative medicine due to its ability to support tissue repair. In our study, we compared the healing process of gingival defects treated with H‐PRF to those that healed naturally and found that the defects treated with H‐PRF healed more quickly and more completely. The treated areas contained stronger and more organized tissue, with improved blood flow. H‐PRF also helps the cells in the gums move to the injury site more effectively, which is important for faster and more complete healing. Our findings suggest that H‐PRF could be a useful tool to enhance the outcomes of soft tissue augmentation around natural teeth or implants, which would lead to healthier and stronger gingiva for patients.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"247 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putting gingival bleeding front and center when assessing dietary guidelines","authors":"Philippe P. Hujoel","doi":"10.1002/JPER.24-0655","DOIUrl":"10.1002/JPER.24-0655","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"96 6","pages":"691-693"},"PeriodicalIF":4.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of smoking over one pack daily on implant healing and health: A cohort study.","authors":"Yaniv Mayer,Eran Gabay,Eli E Machtei,Eli Regev,Ofir Ginesin,Zvi Gutmacher,Jacob Horwitz,Luigi Canullo,Jamil Awad Shibli,Hadar Giladi Zigdon","doi":"10.1002/jper.11362","DOIUrl":"https://doi.org/10.1002/jper.11362","url":null,"abstract":"BACKGROUNDThis prospective cohort trial examines the effects of heavy smoking on peri-implant marginal bone loss (MBL) and implant survival rates over 15 months.METHODSThirty subjects, categorized as either smokers (more than 20 cigarettes daily for over 5 years) or non-smokers, were initially recruited with pocket depths ≤ 5 mm and at least one missing tooth. Urine cotinine assay was used to confirm smoking status. Implants were placed and restored after 4 months. Clinical, radiographic and stability variables were assessed at placement, 15, 24, and 67 weeks. Measurements included marginal bone height, peri-implant pocket depth, implant stability, bleeding on probing, and plaque index. Statistical analyses included Mann-Whitney tests for continuous variables, Fisher exact tests for categorical variables, and generalized estimating equations for longitudinal changes.RESULTSThirteen implants were installed in the smoker group (11 subjects) and 18 in the non-smoker group (18 subjects). Survival rates were lower in smokers (84.6%) compared with non-smokers (94.4%). Smokers experienced significantly greater marginal bone loss 12 months after final reconstruction (1.5 ± 0.3 mm versus 0.7 ± 0.6 mm; p = 0.008). Pocket depth was slightly greater in smokers but this did not reach statistical significance.CONCLUSIONSHeavy smoking significantly increases marginal bone loss and decreases implant survival. Further research is needed to corroborate these findings and develop intervention programs.PLAIN LANGUAGE SUMMARYHeavy smoking is a well-known risk factor for poor dental health, yet its effects on dental implants are less frequently examined. This study investigated how heavy smoking (more than 20 cigarettes daily for at least 5 years) impacts the success of dental implants. We monitored 29 patients, including both heavy smokers and non-smokers, over 15 months after implant placement and restoration. We evaluated bone loss, implant stability, and success rates. Our results showed that heavy smokers experienced significantly more bone loss-twice as much as non-smokers-along with slightly reduced implant stability and survival. These adverse outcomes likely relate to smoking's negative effects on bone healing and immune function. Our findings underscore the importance of addressing smoking before implant procedures and suggest that quitting smoking could greatly improve long-term outcomes. Further research is needed to develop strategies for mitigating the risks of smoking in implant dentistry.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"598 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AO/AAP consensus on prevention and management of peri-implant diseases and conditions: Summary report","authors":"Hom-Lay Wang, Gustavo Avila-Ortiz, Alberto Monje, Purnima Kumar, Javier Calatrava, Tara Aghaloo, Shayan Barootchi, Joseph P. Fiorellini, Maria Elisa Galarraga-Vinueza, Joseph Kan, Guo-Hao Lin, Andrea Ravida, Muhammad H. A. Saleh, Lorenzo Tavelli, AO/AAP Consensus Participants, Paul S. Rosen","doi":"10.1002/JPER.25-0270","DOIUrl":"10.1002/JPER.25-0270","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The exponential increase in dental implant use has led to a parallel rise in peri-implant diseases (PID), adversely affecting implant therapy success and patient quality of life. Efforts have been made by the dental community to understand systemic, behavioral, and site-level risk factors involved in the etiologies and pathogenesis of PID and conditions and to develop standardized treatment protocols for the management of these clinical entities. The 2024 Academy of Osseointegration/American Academy of Periodontology (AO/AAP) consensus aimed to integrate the best available evidence and expert opinion into a unified framework for the prevention and management of PID and conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Focused questions were previously addressed in eight systematic reviews that were grouped into two main topics. Group 1 evaluated systemic and local risk factors/indicators for the development of peri-implant mucositis and peri-implantitis, peri-implant soft tissue deformities, as well as prosthetic factors associated with peri-implant marginal bone loss. Group 2 focused on therapeutic strategies for the management of PID, encompassing nonsurgical debridement, implant surface decontamination methods, and surgical interventions (both nonreconstructive and reconstructive). Structured consensus discussions were held during an on-site meeting in Oak Brook, Illinois (August 14–16, 2024) to inform evidence-based recommendations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A plethora of systemic, behavioral, and local factors may play a pivotal role in the onset and progression of PID and conditions. Key systemic and behavioral risk factors include history of periodontitis, smoking, uncontrolled diabetes, poor microbial biofilm control, and obesity, while implant malposition, unfavorable prosthetic factors, and suboptimal peri-implant soft tissue phenotypical features are relevant site-related factors. Peri-implant mucositis may be effectively managed with nonsurgical debridement and control of risk factors. This possibly represents the first step of treatment of peri-implantitis, whereas more advanced cases require individualized surgical approaches, ranging from flap-for-access, resective, reconstructive, or soft tissue augmentation procedures. Supportive peri-implant maintenance is essential for long-term peri-implant tissue stability and health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>An evidence-based flow diagram combined with expert opinion was generated for clinicians to man","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"96 6","pages":"519-541"},"PeriodicalIF":4.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.25-0270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between high serum ferritin and periodontitis: A population-based cross-sectional preliminary study.","authors":"Susilena Arouche Costa, Cecilia Cláudia Costa Ribeiro, Ana Regina Oliveira Moreira, Gustavo G Nascimento, Soraia de Fátima Carvalho Souza","doi":"10.1002/JPER.24-0491","DOIUrl":"https://doi.org/10.1002/JPER.24-0491","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate the association between high serum ferritin levels and periodontitis considering pathways induced by sociodemographic and behavioral factors, serum inflammation, and metabolic risk.</p><p><strong>Methods: </strong>Data from 7283 individuals who participated in the Third National Health and Nutrition Examination Survey (NHANES III) were analyzed. We estimated indirect and direct pathways for the association between high serum ferritin levels (in quintiles) and periodontitis. A theoretical model was constructed to evaluate the association between high serum ferritin and periodontitis, considering direct and indirect (mediated) pathways, including poverty, age, smoking, alcohol consumption, obesity, iron consumption, serum inflammation (C-reactive protein [CRP]), and insulin resistance (Homeostatic Model Assessment of Insulin Resistance [HOMA-IR]), analyzing through structural equation modeling (SEM).</p><p><strong>Results: </strong>Higher ferritin levels were directly associated with periodontitis (standardized coefficient [SC] = 0.074, standardized error [SE] = 0.033, p-value = 0.025). Furthermore, higher ferritin mediated the association between serum inflammation (SC = 0.012, SE = 0.005, p-value = 0.033) and periodontitis.</p><p><strong>Conclusion: </strong>Higher ferritin levels may play a role in periodontitis as part of a systemic inflammation mechanism.</p><p><strong>Plain language summary: </strong>Mechanisms that justify the association between increased ferritin and periodontitis are still poorly understood. Ferritin is the main marker of iron stores, but it can be influenced by several factors that are also related to periodontitis. Our study investigated indirect (inflammatory) and direct (local) mechanisms for the association between ferritin and periodontitis. The systemic inflammatory mechanism partially explained the association between ferritin and periodontitis. Elevated ferritin levels remained directly associated with periodontitis even after adjustment for confounding, indicating the possibility of a direct mechanism. Elevated levels of ferritin may contribute to the severity and extent of periodontitis.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, incidence, risk, and protective factors for soft tissue dehiscences at implant sites in the absence of disease: An AO/AAP systematic review and meta-regression analysis","authors":"Lorenzo Tavelli,&nbsp;Shayan Barootchi","doi":"10.1002/JPER.24-0119","DOIUrl":"10.1002/JPER.24-0119","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The aim of the present review was to evaluate the prevalence and incidence of soft tissue dehiscences at implant sites in absence of disease, together with the related risk and protective factors.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A systematic search was conducted to identify cross-sectional and prospective studies reporting information on soft tissue dehiscences. Mixed-effects uni- and multi-level regression analyses were performed to identify predictive factors associated with these conditions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 221 eligible studies were included. Soft tissue dehiscences (“recessions”) were identified as peri-implant soft tissue dehiscences (PSTDs), Mucosal level (ML) apical shifts, and mucosal recessions (MRECs). The mean prevalence of PSTD and MREC was 46.2% and 23.1%, respectively. The incidence of PSTD, MREC, and apical shift of ML within 5 years following loading was up to 38.3%, 47.8%, and 23.6%, respectively. Limited mucosal thickness (MT), immediate implant therapy, and lack of peri-implant soft tissue augmentation were risk factors for PSTD, while limited MT, lack of/limited keratinized mucosa (KM) width, and immediate implant therapy were risk factors for ML apical shift. Guided implant surgery, bone grafting at implant placement, soft tissue augmentation, and adequate KM and MT were protective factors for the stability of ML. Lack of/limited KM width and interproximal marginal bone loss were risk factors for MREC.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Soft tissue dehiscences are commonly observed at implant sites. Risk and protective factors associated with PSTD, ML apical shift, and MREC were identified. A new diagnostic system and format for assessing and reporting soft tissue dehiscence at implant sites was proposed.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain Language Summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The aim of the present review was to evaluate the prevalence and incidence of soft tissue recession (“gum loss”) at healthy implant sites. A systematic search was conducted to identify studies reporting information on soft tissue recession at implant sites. The statistical analysis also explored correlations of different factors with soft tissue recession. A total of 221 studies were included. Soft tissue dehiscences (“recession”) were identified as peri-implant soft tissue dehiscences (PSTDs), Mucosal Level (ML) apical shift, and mucosal recessions (MRECs). ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"96 6","pages":"562-586"},"PeriodicalIF":4.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.24-0119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, incidence, systemic, behavioral, and patient-related risk factors and indicators for peri-implant diseases: An AO/AAP  systematic review and meta-analysis","authors":"Maria Elisa Galarraga-Vinueza,&nbsp;Sarah Pagni,&nbsp;Matthew Finkelman,&nbsp;Todd Schoenbaum,&nbsp;Leandro Chambrone","doi":"10.1002/JPER.24-0154","DOIUrl":"10.1002/JPER.24-0154","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A profound understanding of the epidemiology of peri-implant diseases (PIDs) is essential for the development of preventive approaches to mitigate the occurrence and progression of peri-implant biological complications. The present systematic review and meta-analysis aimed to assess the incidence, prevalence, systemic, behavioral, and patient-related risk indicators and factors for PIDs in adult patients with dental implants.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Clinical studies assessing the prevalence, incidence, systemic risk indicators, and risk factors for PIDs were considered eligible for inclusion. MEDLINE–PubMed, EMBASE, Cochrane Central Library, and ClinicalTrials.gov electronic databases were searched for published articles. Pooled data analyses were performed using random-effects models to identify risk indicators and factors for PIDs.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Of 1120 potentially eligible records, 102 studies met the eligibility criteria and were included in this systematic review. Prevalence rates at the patient level for peri-implant mucositis and peri-implantitis were 46% (95% confidence interval [CI], 41–51) and 21% (95% CI, 17–24), respectively. Weighted mean incidence rates at the patient level for peri-implant mucositis and peri-implantitis were 53% and 22%, respectively, within 20 years of function. Pooled estimates identified periodontitis, obesity, and smoking habits as significant systemic risk indicators for mucositis. For peri-implantitis, the significant risk indicators were periodontitis, diabetes mellitus, smoking habits, and alcohol consumption. Only risk indicators could be identified in the selected evidence.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;More than half of the patients treated with dental implants were affected by PIDs over a 10-year follow-up period, with peri-implant mucositis being the most prevalent condition. Periodontitis and smoking were identified as risk indicators for the development of both PIDs. Obesity was identified as a potential risk indicator for mucositis, while diabetes mellitus and alcohol consumption were recognized as potential risk indicators for peri-implantitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain Language Summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This systematic review looked at the causes and frequency of problems around dental implants, known as PIDs, which include conditions like peri-implant mucositis (inflammation around the i","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"96 6","pages":"587-633"},"PeriodicalIF":4.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.24-0154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of prosthetic designs on peri-implant bone loss: An AO/AAP systematic review and meta-analysis","authors":"Guo-Hao Lin,&nbsp;Eric Lee,&nbsp;Shayan Barootchi,&nbsp;Paul S. Rosen,&nbsp;Donald Curtis,&nbsp;Joseph Kan,&nbsp;Hom-Lay Wang","doi":"10.1002/JPER.24-0144","DOIUrl":"10.1002/JPER.24-0144","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Implant prosthetic design significantly impacts peri-implant health. This systematic review and meta-analysis explored emerging concepts in prosthetic considerations, appraising the level of evidence and clinical significance of these suprastructures on peri-implant marginal bone loss (MBL).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;An electronic search of three databases and a manual search of peer-reviewed journals for relevant articles published in English between January 1980 and December 2023 were performed. Eligible studies featured dental implants restored within ≥12 months, with ≥10 implants in each group. Inverse variance meta-analyses were performed to compare various prosthetic factors and their impact on MBL and the risk of peri-implantitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Screw-retained versus cement-retained prostheses demonstrated no significant difference in MBL (six articles, &lt;i&gt;p&lt;/i&gt; = 0.51). Nonsplinted implants exhibited lower MBL compared to their splinted counterparts (eight articles, &lt;i&gt;p&lt;/i&gt; = 0.04). Platform-switched abutments were correlated with reduced MBL compared to platform-matched ones (20 articles, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001). Internal connections, particularly conical ones, displayed less MBL than external connections (20 articles, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001). The crown-to-implant ratio did not significantly affect MBL (five articles, &lt;i&gt;p&lt;/i&gt; = 0.32). Abutment heights ≥2 mm are associated with less MBL than heights &lt;2 mm (12 articles, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001). Implementing a one abutment-one time protocol resulted in less MBL than repeated abutment disconnections (10 articles, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001). Emergence angles &lt;30° and a concave/straight profile led to lower peri-implantitis risk (two articles each; &lt;i&gt;p&lt;/i&gt; = 0.05 and &lt;i&gt;p&lt;/i&gt; = 0.03, respectively).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Nonsplinted implants, platform-switched abutments, abutment heights ≥2 mm, and a one abutment-one time approach yielded significant reductions in MBL compared to their counterparts. Furthermore, emergence angles &lt;30° and a concave/straight emergence profile were linked to decreased peri-implantitis risk. Meanwhile, factors such as screw-retained versus cement-retained prostheses and crown-to-implant ratio yielded no significant difference in MBL.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain Language Summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The design of implant-supported tooth replicas plays a k","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"96 6","pages":"634-651"},"PeriodicalIF":4.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.24-0144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical- and implant-related factors and onset/progression of peri-implant diseases: An AO/AAP systematic review","authors":"Alberto Monje,&nbsp;Shayan Barootchi,&nbsp;Paul S. Rosen,&nbsp;Hom-Lay Wang","doi":"10.1002/JPER.24-0083","DOIUrl":"10.1002/JPER.24-0083","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The objective of this systematic review was to shed light on the importance of surgical- and implant-related factors on the onset/progression of peri-implant diseases. This systematic review provides an evidence-based overview on the prevention of peri-implant diseases for the Academy of Osseointegration (AO)/American Academy of Periodontology (AAP) Consensus Conference held in August 14–16, 2024 in Oakbrook, IL, USA.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Systematic screening of electronic sources was performed to identify clinical studies reporting on the impact of surgical- and implant-related factors on peri-implant diseases. To fulfil the inclusion criteria, a composite clinical and radiographic case definition for peri-implant mucositis and/or peri-implantitis had to be reported. Prevalence or incidence (%) of peri-implant diseases was extracted at patient- and implant-level. Moreover, odds/hazard ratios were collected to explore potential associations.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Overall, 34 articles were included in the qualitative synthesis. Of these, 21 explored surgical-related factors (&lt;i&gt;N&lt;/i&gt;&lt;sub&gt;patients &lt;/sub&gt;= 2752, &lt;i&gt;N&lt;/i&gt;&lt;sub&gt;implants &lt;/sub&gt;= 7591), while 13 reported implant-related factors (&lt;i&gt;N&lt;/i&gt;&lt;sub&gt;patients &lt;/sub&gt;= 1192, &lt;i&gt;N&lt;/i&gt;&lt;sub&gt;implants &lt;/sub&gt;= 4072). Given the high heterogeneity across the studies, only qualitative assessment was performed. Clinical evidence proved that surgical-related factors, in particular inadequate implant position and, to a lower extent, implants placed in regenerated bone, are more prone to exhibit peri-implantitis, but not peri-implant mucositis. With regards to specific implant-related factors, insufficient evidence, did not allow for exploring specific associations with the onset/progression of peri-implant diseases. However, it was found that a short distance from the prosthetic margin to crestal bone during implant placement may be a predisposing factor for peri-implantitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Clinical evidence linking surgical- and implant-related factors and peri-implant diseases is sparsely reported in the literature. Nevertheless, it appears that implant malposition plays a crucial role on the onset/progression of peri-implantitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain Language Summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The objective of this systematic review was to shed light on the importance of surgical-and implant-","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"96 6","pages":"542-561"},"PeriodicalIF":4.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.24-0083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}