Journal of periodontology最新文献

{"title":"Biomaterials for resolution of peri-implantitis: Consensus report of Workgroup 2 of the IADR Implantology Research Group Best Evidence Consensus Symposium on Peri-Implant Disease and Its Treatment.","authors":"Sukirth M Ganesan,David R Fraser,Mustafa Tattan,Jessica M Latimer, ,Georgios Kotsakis","doi":"10.1002/jper.24-0432","DOIUrl":"https://doi.org/10.1002/jper.24-0432","url":null,"abstract":"BACKGROUNDPeri-implantitis is a destructive disease affecting the tissues surrounding dental implants. Biomaterials may be applied during surgical treatment to reconstruct bony defects and support soft tissue healing. However, current evidence is unclear if these treatments increase the likelihood of peri-implantitis resolution.METHODSA systematic review and meta-analysis was performed on randomized controlled trials (RCTs) comparing surgical treatment with addition of reconstructive biomaterials (intervention) versus surgical treatment of peri-implantitis alone (comparison) with follow-up periods of at least 12 months. Resolution of peri-implantitis, defined as a reduction of probing pocket depth (PPD) to ≤5 mm, absence bleeding on probing (BOP), and stable or decreasing radiographic defect level (RDL), was selected as the primary outcome. Secondary outcomes included RDL reduction, buccal mucosal recession (REC), and patient-related outcome measures (PROMs). Risk of bias and quality of evidence were calculated using established guidelines.RESULTSSeven studies reporting on 402 patients with 405 implants met inclusion criteria. Wide variations in outcome reporting prevented the synthesis and quantitative comparison of peri-implantitis disease resolution between intervention and comparison groups. Individual meta-analyses showed a weighted mean difference (WMD) in PPD reduction of 0.28 mm [95% confidence interval (CI) -0.30, 0.86] and a relative risk (RR) for absence of BOP of 1.11 (95% CI 0.78, 1.59) for the inclusion of biomaterials (intervention) over access flap alone (comparison). For RDL reduction, a WMD of 1.08 mm (95% CI 0.41, 1.74) with significant heterogeneity (Q p-val: < 0.01, I2: 85%) and for REC, a WMD of -0.38 (95% CI -0.66, -0.11) was found, both in favor of the intervention. Analysis of the heterogeneity affecting RDL identified a positive effect on RDL when hydrogen peroxide but not rotary titanium brushes were used as an adjunct for implant surface debridement.CONCLUSIONCurrent evidence suggests that incorporating reconstructive biomaterials into surgical treatment may not definitively enhance the likelihood of peri-implantitis disease resolution. However, this lack of effect may be due to other factors such as implant surface treatments which may also affect clinical outcomes. Overall, this work highlights the critical need for standardizing the reporting of composite outcomes for the resolution of peri-implantitis disease and controlling for implant surface treatment effects when assessing reconstructive biomaterials.PLAIN LANGUAGE SUMMARYPeri-implantitis is a destructive disease affecting tissues around dental implants. We studied whether adding reconstructive biomaterials (i.e., biomaterials used to improve the likelihood of new bone formation or bone defect fill) to surgical treatments improves the clinical condition, meaning no further bone loss, probing pocket depths (PPD) ≤5 mm, and no bleeding on probing (BOP). We review","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"25 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147536332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural alterations in osteocyte dendrites and lacunar‐canalicular networks of the mandible of ovariectomized mice","authors":"Bei Gao, Jin Bai, Rui Xiao, Jiaqi Li, Mengying Wang, Ziyi Wang, Zhihui Feng, Jianfeng Shi, Zhongbo Liu","doi":"10.1002/jper.70134","DOIUrl":"https://doi.org/10.1002/jper.70134","url":null,"abstract":"Background Postmenopausal osteoporosis (PMOP) leads to systemic bone metabolism disorders, significantly affecting oral bone health and complicating treatment. Osteocytes, the most abundant cells in bone tissue, play a crucial role in bone remodeling through cellular communication. However, the mineralized bone matrix surrounding osteocytes presents significant challenges for studying their dendritic networks. Methods Eight week old C57BL/6J female mice were randomly assigned to either a Sham group or an ovariectomized (OVX) group. The PMOP animal model was established via bilateral ovariectomy and analyzed after 12 weeks. Osteocyte dendrites and the lacuno‐canalicular network (LCN) were examined via SEM and immunohistochemical staining. Quantification of nodes and connectomic measurements were performed for LCN and phalloidin network analyses. Furthermore, the expression levels of MMP13 and CTSK were assessed via immunohistochemical staining and real‐time PCR. Results Our findings revealed that both Sham and OVX mice exhibited two distinct morphological types of osteocyte lacunar structures in the mandible. In Sham mice, direct communication was observed between osteocytes, adjacent cells, and blood vessels via canaliculi. In contrast, connectivity analysis of the osteocyte dendritic network in OVX mice revealed a reduced material transport capacity between cells compared with Sham controls. OVX‐induced systemic osteoporosis altered the osteocyte dendritic network and lacunar canaliculi in the mandible, potentially due to periluminal canalicular remodeling. Conclusions This study offers new insights into the changes and mechanisms affecting the dendritic network and lacunar canaliculi of mandibular osteocytes in postmenopausal osteoporosis, contributing to a deeper understanding of oral bone lesions in this condition. Plain Language Summary After menopause, many women develop osteoporosis—a condition where bones become weak and break easily. This not only affects bones such as the spine or hips but also damages the jawbone, making dental treatments harder. We wanted to understand how osteoporosis weakens the jawbone by studying tiny bone cells called osteocytes, which act like “messengers” controlling bone health. Using advanced microscopy and special staining techniques, we mapped communication networks between osteocytes in the jawbone (like tracing telephone wires between cells). We then compared bone structures between healthy mice and mice with osteoporosis after ovary removal. Osteoporosis damaged the “wires” (dendrites) connecting osteocytes, reducing their ability to share nutrients and signals. It also widened tunnels (canaliculi) around osteocytes—like potholes in roads—disrupting their links to blood vessels and neighboring cells. These changes likely occur because osteoporosis impairs the bone's self‐repair system around these tunnels. Our discovery that osteoporosis breaks bone cell networks reveals a new mechanism for jawbone weake","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147524327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dasatinib and quercetin prevent alveolar bone loss in aged mice.","authors":"Luisa S Battistelli, Renata M Moraes, Yuri C Santos, Jaqueline L Ribeiro, Maíra T Garcia, Renata F Prado, Florent Elefteriou, Ana Lia Anbinder","doi":"10.1002/jper.70115","DOIUrl":"https://doi.org/10.1002/jper.70115","url":null,"abstract":"<p><strong>Background: </strong>Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro-inflammatory environment which may exacerbate tissue damage. Senolytics, such as dasatinib and quercetin (D&Q), eliminate senescent cells, offering potential therapeutic benefits. We evaluated the effects of D&Q on ABL during physiological aging and experimental periodontitis.</p><p><strong>Methods: </strong>This study evaluated the effects of D&Q in two in vivo models: aging and ligature-induced periodontitis. In the aging model, 24 male C57BL/6 mice were allocated to CTRL (control-30 weeks of age), AGED (vehicle-treated, euthanized after 10 months), or D&Q (monthly gavage of D&Q [5 mg/kg and 50 mg/kg] for 10 months). In the periodontitis model, 24 Wistar rats (12 weeks old) were divided into CTRL, EP (experimental periodontitis, ligature + P. gingivalis), or D&Q (EP + weekly D&Q at 5 mg/kg and 50 mg/kg). The ABL and bone microarchitecture were assessed by microcomputed tomography and histomorphometry, and gene expression was also analyzed. The microarchitecture of the femurs was evaluated for systemic effects.</p><p><strong>Results: </strong>In aged mice, D&Q reduced ABL, preserved the femoral cortical microarchitecture, and downregulated Il6, Mmp13 and Lamb1 expression. In contrast, D&Q failed to prevent ABL in the periodontitis model.</p><p><strong>Conclusion: </strong>D&Q treatment mitigated age-related bone loss; but did not prevent EP associated bone loss under the therapeutic regimen used. These results suggest that the effects of senolytic therapy depend on disease context and treatment conditions.</p><p><strong>Plain language summary: </strong>Aging increases the risk of periodontitis due to immune decline, chronic inflammation, and the accumulation of senescent cells, which release inflammatory factors that damage tissues. Senolytic drugs, such as dasatinib and quercetin (D&Q), selectively eliminate senescent cells and have shown promise in age-related diseases. In this study, we tested whether D&Q could reduce alveolar bone loss associated with aging or experimental periodontitis. The D&Q treatment protected aged mice by reducing bone loss, but it failed to prevent bone loss in the periodontitis model. These results suggest that the benefits of senolytic therapy may depend on disease context and treatment conditions.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucogingival surgery techniques: Coronally advanced flap versus tunnel approach.","authors":"Sofia Aroca,Giovanna Laura Di Domenico,Massimo de Sanctis","doi":"10.1002/jper.70116","DOIUrl":"https://doi.org/10.1002/jper.70116","url":null,"abstract":"BACKGROUNDMucogingival surgery techniques for treating gingival recessions (GRs) have evolved significantly over decades, reflecting advances in surgical understanding and patient demands. This narrative review tracesexamines the historical development of the coronally advanced flap-multiple coronally advanced flap (CAF/MCAF) and tunnel techniques, highlighting how these procedures have been refined to improve clinical outcomes and esthetic results. Emphasis is placed on the biological principles underlying these approaches and their adaptation based on growing scientific evidence.METHODSA comprehensive review of the literature was conducted, synthesizing historical milestones and recent clinical studies including randomized controlled trials and systematic reviews. The focus was on comparing the CAF and tunnel approaches in terms of surgical principles, technical variations, and effectiveness in root coverage treatment, considering adjunctive use of grafting materials.RESULTSBoth the CAF/MCAF and tunnel techniques demonstrate high predictability and effectiveness in GR coverage. Their evolution reflects a trend toward minimally invasive surgery, improved vascularization, and tissue stability. Current evidence supports the choice of technique based on defect characteristics, tissue phenotype, and esthetic requirements, with connective tissue grafts (CTGs) and biomaterials enhancing outcomes in many cases.CONCLUSIONSBoth CAF and tunnel techniques provide predictable root coverage, enhanced by CTGs (gold standard) or substitutes (reducing morbidity but with limited evidence). The choice between the two techniques should be guided by recession and tissue phenotype characteristics to optimize functional and esthetic outcomes.PLAIN LANGUAGE SUMMARYThis study highlights the history and development of two key mucogingival surgical techniques, the coronally advanced flap and the tunnel technique, demonstrating that both provide reliable and effective options for treating gingival recessions, enabling successful root coverage outcomes.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"17 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterial used to counteract ridge reduction following the removal of adjacent teeth: A randomized controlled multicenter study.","authors":"Denis Cecchinato,Enrico Corrà,Eriberto Bressan,Marika Gervasi,Marco Menoncin,Enrico Savio,Marco Toia","doi":"10.1002/jper.70084","DOIUrl":"https://doi.org/10.1002/jper.70084","url":null,"abstract":"BACKGROUNDAlveolar ridge resorption (ARP) is a well-recognized consequence of tooth extraction, and multiple adjacent extractions may lead to greater ridge reduction than single-tooth extractions. This multicenter randomized controlled trial aimed to assess ridge remodeling after removing 2 adjacent teeth and whether socket grafting with deproteinized bovine bone mineral with collagen (DBBM-C) plus a collagen membrane could counteract the ridge reduction.METHODSForty-two patients requiring 2 adjacent tooth extractions were randomly assigned to either Test (DBBM-C graft + collagen membrane) or Control (natural healing). Impressions were taken immediately after extraction and at 6 months, and models were analyzed to measure changes in horizontal ridge width (bucco-lingual at 3 mm below the crest) and vertical ridge height (buccal and lingual).RESULTSAt 6 months, grafted sites had significantly less ridge reduction than controls. Horizontal ridge width reduction averaged 57.7% in Control versus 23.0% in Test (p < 0.001). Vertical height loss was also greater in controls (buccal 3.0 mm vs. 1.5 mm; lingual 2.2 mm vs. 1.3 mm; p < 0.001). Both mesial and distal sockets benefited similarly from grafting, with comparable preservation at each site.CONCLUSIONFilling adjacent extraction sockets with DBBM-C and covering with a collagen membrane significantly reduced horizontal and vertical alveolar ridge resorption compared to unassisted healing. This approach effectively preserves bone volume after multiple tooth extractions, which may facilitate later implant placement.PLAIN LANGUAGE SUMMARYWhen 2 neighboring teeth are removed, the area tends to shrink in width and height as it heals. This bone loss can make it more difficult to place dental implants later. In this study, we tested a method to help maintain the bone after removing 2 adjacent teeth. In the Test group, the empty tooth sockets were filled with a bone graft material (deproteinized bovine bone mineral and collagen) and covered with a collagen membrane. In the Control group, the sites were left to heal physiologically. A total of 42 patients participated, each needing 2 side-by-side teeth removed. After 6 months of healing, we compared models of the patients from right after the extractions to those taken 6 months later. The results showed that the group with the bone graft and membrane had much less bone shrinkage than the group without them. The 2 extraction sites in the graft group maintained their bone height and width similarly. In summary, using a bone substitute material and membrane immediately after multiple tooth extractions helped preserve the jawbone, which could make future treatments like dental implants more successful.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the subgingival HerBiome and HisBiome over the human healthspan.","authors":"Rahul Nikam,Kazune Pax,Michelle Lee-Scott Beverly,Purnima S Kumar","doi":"10.1002/jper.70098","DOIUrl":"https://doi.org/10.1002/jper.70098","url":null,"abstract":"BACKGROUNDUnderstanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age-related oral and systemic diseases.METHODSSubgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years. 16S amplicon sequencing was performed. 80 million sequences were annotated and analyzed through the QIIME pipeline, principal components analysis (PCA) used for dimensionality reduction, LefSe to identify driver species, beta dispersion to measure inter-subject variability, and machine learning algorithm (RandomForest package in R [RF]) to validate the results. Causal mediation models were implemented to investigate the influence of aging on the male and female microbiomes.RESULTSPCA demonstrated significant class separation based on sex (p < 0.001, permutational multivariate analysis of variance [PERMANOVA]). Males demonstrated higher alpha diversity (p < 0.001, Wilcoxon signed-rank test of the Shannon diversity index), but also higher inter-subject heterogeneity p < 0.001, ANOVA). RF identified males with 0.99 sensitivity, 0.15 specificity, and accuracy of 85%. Age exerted an almost complete mediation effect, with significant differences in the trajectory and pattern of aging between males and females. Females > 30 demonstrated a lower microbial diversity (p < 0.001) and higher levels of Fusobacterium nucleatum (p < 0.001), while the male microbiome remained highly personalized throughout the lifespan, without defined patterns of aging.CONCLUSIONSSex and age interact to influence the subgingival microbiome. These findings might explain differing disease susceptibilities in either sex, as well as informing personalized prevention and intervention based on age and sex. Further studies using granular -omics approaches are needed to advance our knowledge.PLAIN LANGUAGE SUMMARYPeriodontal (gum) diseases are caused by a breakdown in the intricate balance between bacteria that live under the gumline and the local immune response. Since periodontal diseases have been reported to be more common in men than in women, we set out to investigate whether these bacterial communities are intrinsically different between the 2 sexes, and whether these differences are sustained over the lifespan. Using deep-sequencing technology to analyze the microbiomes of 941 individuals, we discovered that sex at birth is indeed a determining factor in the types of bacteria that live under the gums. Aging trajectories and patterns also differ between men and women, with women demonstrating a distinct shift after 30 years of age, and men showing no definite age-based change. These findings have important implications for the cause of periodontitis in either sex, as well as the potential to personalize therapy based on age and sex.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"12 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association study of periodontitis severity and progression","authors":"Flavia Teles,&nbsp;Ganesh Chandrasekaran,&nbsp;Lynn Martin,&nbsp;Poojan Shrestha,&nbsp;Kevin Moss,&nbsp;Michele Patel,&nbsp;Michael J. Kallan,&nbsp;Camila Furquim,&nbsp;Andrew J. Cucchiara,&nbsp;James D. Beck,&nbsp;Kari E. North,&nbsp;Joseph Glessner,&nbsp;Kimon Divaris","doi":"10.1002/jper.70017","DOIUrl":"10.1002/jper.70017","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To add to the knowledge base of periodontal genomics, we carried out a genome-wide association study (GWAS) of periodontitis severity and progression among 416 mixed-ethnicity adult participants of a periodontitis clinical study.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Participants were 168 adults (mean age = 50 years, 46% males) with severe periodontitis and 248 adults (mean age = 48 years, 40% males) without severe periodontitis, including 147 with mild periodontitis and 101 periodontally healthy. Disease progression information over a 12-month period was available for 368 of these participants. Single marker discovery analysis relied on logistic regression models adjusted for age, sex, and genetically determined ancestry using a conventional &lt;i&gt;p &lt;/i&gt;&lt; 5x10&lt;sup&gt;−8&lt;/sup&gt; genome-wide statistical significance criterion. Genome-wide significant loci were annotated and examined for associations with periodontal disease traits in external cohorts of 10,019 Hispanic/Latinos, 4,554 European Americans, and 973 African Americans.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;All GWAS single nucleotide polymorphisms (SNPs) explained 34% of phenotypic variance between periodontitis cases and controls and 57% of the variance in disease progression in this study. We identified 2 genome-wide significant loci associated with disease progression (&lt;i&gt;SUMO2P2&lt;/i&gt;, small ubiquitin-like modifier 2, rs72691774, &lt;i&gt;p&lt;/i&gt; = 1.9x10&lt;sup&gt;−8&lt;/sup&gt;] and &lt;i&gt;CUBN&lt;/i&gt; (cubilin, rs565051161, &lt;i&gt;p&lt;/i&gt; = 3.9x10&lt;sup&gt;−8&lt;/sup&gt;). &lt;i&gt;CUBN&lt;/i&gt; was strongly associated with periodontal disease in the independent samples of African Americans (rs7082270, &lt;i&gt;p &lt;/i&gt;= 3.1x10&lt;sup&gt;−7&lt;/sup&gt;) and Hispanic/Latinos (rs1276710, &lt;i&gt;p&lt;/i&gt; = 1.5x10&lt;sup&gt;−5&lt;/sup&gt;), albeit the lead SNPs were rare and differed in each population. Meanwhile, &lt;i&gt;ZBTB16&lt;/i&gt; (zinc finger and BTB domain-containing 16) showed the strongest evidence of association with severe periodontitis (rs454802, &lt;i&gt;p &lt;/i&gt;= 2.2x10&lt;sup&gt;−7&lt;/sup&gt;).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study's results emanate from a well-characterized cohort of periodontitis severity and progression and add to the knowledge base of periodontal genomics and the underlying individual disease susceptibility.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study assessed the association of gene variants in association with gum disease severity and progression in 416 participants of a","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 2","pages":"247-258"},"PeriodicalIF":3.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aap.onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145765082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From primary to secondary care level: Assessing patient retention of periodontal staging and grading information","authors":"Pasquale Santamaria,&nbsp;Rohan Mangalpara,&nbsp;Thamara Kumar,&nbsp;Tina Lipovec,&nbsp;Luigi Nibali","doi":"10.1002/jper.70008","DOIUrl":"10.1002/jper.70008","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Accurate communication of periodontal stage and grade by general dentists in primary care is critical for patient understanding and engagement, yet patient retention and self-reporting of this information upon referral to secondary care remains unclear.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 372 periodontal patients referred were informed about their diagnosis by their general dentists and then referred to secondary care level. Data were collected through an eight-item periodontal staging and grading (PSG) questionnaire, along with demographic, medical, and dental records. Periodontal diagnoses were classified by a specialist using the 2018 classification system. Associations between clinical diagnosis and patient perception were analyzed using Chi-square tests and Spearman's rank correlation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;While 46.9% of patients diagnosed with periodontitis reported to be informed of their condition, only 19.3% reported knowing their specific stage and grade. Among patients with advanced periodontitis (stage III/IV), self-reported severity often aligned with clinical staging. However, for early-stage disease (stage I/II), perceptions were less accurate, and only 30.2% of grade C patients recognized rapid progression. Significant correlations were found between patient-reported symptoms and clinician-assigned staging: tooth loss (&lt;i&gt;ρ&lt;/i&gt; = 0.69, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001), root exposure (&lt;i&gt;ρ&lt;/i&gt; = 0.638, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001), and tooth mobility (&lt;i&gt;ρ&lt;/i&gt; = 0.55, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Most patients referred to secondary care lacked information on their disease stage and grade. Severe stages and grades were better perceived by patients compared with mild forms of periodontitis. The PSG questionnaire offers a valuable tool for identifying knowledge gaps and guiding tailored discussions in clinical practice.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our study asked 372 people referred for gum disease to fill out a simple eight-question survey about how they see their own gum health and compared their answers to the detailed diagnosis made by periodontists. We found that fewer than one in five patients knew exactly how severe their disease was or how fast it was progressing. People with more advanced gum damage generally understood their condition, but those with mild disease often thought they wer","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 2","pages":"326-335"},"PeriodicalIF":3.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aap.onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic changes in the maxillary sinus following closed sinus augmentation","authors":"Jaret O. Simonsen,&nbsp;Michael P. Mills,&nbsp;Brian L. Mealey,&nbsp;Lea El Hachem,&nbsp;Hassem Geha,&nbsp;Kerri Font,&nbsp;Charles A. Powell","doi":"10.1002/jper.11376","DOIUrl":"10.1002/jper.11376","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The primary objective of this study is to evaluate the accuracy of 3-dimensional (3D) imaging in detecting radiographic and morphological graft changes compared to traditional 2-dimensional (2D) imaging. Additionally, the study aims to assess the distribution of graft material and the extent of resorption occurring between baseline and 6 months post-implant placement following transcrestal sinus augmentation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study employed a transcrestal approach utilizing an osseodensification protocol for sinus augmentation with mineralized freeze-dried bone allograft. Immediately post-operatively, a standardized periapical radiograph (PA) was taken using a standardized paralleling device with bite registration material. Furthermore, a low-volume cone beam computed tomography (CBCT) radiograph was obtained. Following a 6-month healing period, both radiographs were repeated for analysis and comparison to baseline parameters.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 22 subjects completed the study. At 6 months post-surgery, PA evaluations indicated a reduction in apical graft height (AGH) of 55.9%, endo-sinus bone gain (ESBG) reduction of 29.6%, and elevated membrane apex (EMA) reduction of 8.4%. CBCT analysis showed slightly higher reductions, with AGH, ESBG, and EMA reductions of 60.4%, 32.6%, and 12.2%, respectively. A paired &lt;i&gt;t&lt;/i&gt;-test comparing the accuracy of the 2D and 3D models' ability to detect changes in graft material resulted in a &lt;i&gt;p&lt;/i&gt;-value of 0.2168.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periapical imaging is relatively accurate when standardized, whereas CBCT provides a more precise representation of the graft material distribution and reduction. Significant reductions in AGH, ESBG, and EMA were observed at 6 months, with PAs indicating less change in bone augmentation compared to CBCT.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; ClinicalTrials.gov Identifier&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;NCT06296459&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The removal of posterior teeth results in expansion of the maxillary sinus, which can limit the bony support for dental implants. To overcome this, the maxillary sinus can be augmented through various techniques and with various materials. This study evaluated augmenting the sinus with a transcrestal app","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 2","pages":"198-206"},"PeriodicalIF":3.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aap.onlinelibrary.wiley.com/doi/epdf/10.1002/jper.11376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric buccal bone alterations at immediate implant sites with or without soft tissue augmentation: A 6-month assessment","authors":"Mary Jung,&nbsp;Duong Tran,&nbsp;Chi-Ching Chang,&nbsp;Sung K. Kim,&nbsp;Yosuke Tsukiboshi,&nbsp;Seiko Min,&nbsp;Srinivas Ayilavarapu,&nbsp;Chun-Teh Lee","doi":"10.1002/jper.11381","DOIUrl":"10.1002/jper.11381","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study is part of a randomized controlled trial investigating the impact of soft tissue augmentation (STA) using subepithelial connective tissue graft (SCTG) (immediate implant with subepithelial connective tissue graft [ICT] group) or acellular dermal matrix (ADM) (immediate implant with acellular dermal matrix [IAD] group) versus no STA (control) on the clinical outcomes following immediate implant placement (IIP). This study aimed to investigate volumetric buccal bone dimensional changes at immediate implant sites 6 months after the surgery.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Forty-five patients requiring extraction of a maxillary anterior tooth or premolar and randomly assigned to one of the three groups were included. Cone-beam computed tomography (CBCT) images were obtained prior to tooth extraction and 6 months after IIP and then superimposed to evaluate 3D (volumetric) and 2D (linear) changes in buccal bone dimensions around the implant. Measurements included three regions of interest (coronal, middle, and apical segments). The associations between clinical factors and 3D buccal bone dimensional changes were analyzed using linear regression analysis. The correlations between 3D and 2D measurements were analyzed using Pearson's correlation coefficient. Statistical significance was assessed using an alpha level of 0.05.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Volumetric bone dimensional changes were not significantly different between the groups. The greatest amount of bone loss occurred in the coronal segment (ICT: −14.99 ± 4.29 mm&lt;sup&gt;3&lt;/sup&gt;; IAD: −13.60 ± 3.97 mm&lt;sup&gt;3&lt;/sup&gt;; Control: −12.58 ± 4.09 mm&lt;sup&gt;3&lt;/sup&gt;; &lt;i&gt;p&lt;/i&gt; = 0.286). The thick bone morphotype was significantly associated with increased absolute volumetric bone loss (&lt;i&gt;p&lt;/i&gt; = 0.001, 0.041, and 0.013 for coronal, middle, and apical segments, respectively). Measurements of 3D and 2D bone dimensional changes had low to high correlations (range 0.39–0.95) in different segments.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;STA did not significantly affect bone dimensional loss at 6 months. Linear measurements may not fully represent volumetric bone dimensional changes at immediate implant sites.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Clinical trial registration&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study is part of a randomized controlled trial (RCT) registered with ClinicalTrials.gov (ID NCT02864862). The title of the trial is &lt;i&gt;Esthetic&lt;/i&gt; &lt;i","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 2","pages":"220-233"},"PeriodicalIF":3.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aap.onlinelibrary.wiley.com/doi/epdf/10.1002/jper.11381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}