Journal of periodontology最新文献

{"title":"Roles of CCL2 in peri-implantitis and its potential as a treatment target: An animal study","authors":"Anqi Zhou, Yiping Wei, Wenting Jiang, Shasha Yuan, Ting Yang, Yaqian Mo, Xuekang Wang, Qingqing Li, Zhanming Song, Zhongtian Liu, Ning Li, Zhaohuai Zhang, Ying Wang, Wenjie Hu","doi":"10.1002/JPER.25-0058","DOIUrl":"10.1002/JPER.25-0058","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>CC-chemokine ligand 2 (CCL2) plays pivotal roles in many osteoimmune disorders, while its role in peri-implantitis is unknown. The main research question aimed to address in this study is investigating the specific roles of CCL2 in peri-implantitis and assessing the preventive and therapeutic effects of bindarit on experimental peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Firstly, the expression profile of CC-chemokine receptor 2 ligands in human peri-implantitis was ascertained by processing and analyzing datasets from the Gene Expression Omnibus database. Then the experimental peri-implantitis model was established in mice by suture ligation, and the soft tissue inflammation and hard tissue resorption were compared in CCL2 knockout (<i>Ccl2<sup>−/−</sup></i>) mice and wild-type mice with experimental peri-implantitis to evaluate the impact of CCL2 in vivo by visual examination, microcomputed tomography, hematoxylin-eosin staining, tartrate-resistant acid phosphatase staining, immunohistochemistry staining, flow cytometry, and quantitative real-time polymerase chain reaction. Furthermore, using both preventive and therapeutic administration routes, the effectiveness of bindarit, which inhibited the expression of CCL2, was evaluated in experimental peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CCL2 demonstrated a significant predominant expression among the ligands of CC-chemokine receptor 2 in human peri-implantitis. CCL2 was significantly upregulated in the ligature-induced peri-implantitis model (<i>p</i> = 0.0007), and CCL2 deficiency resulted in significantly decreased monocytes/macrophages infiltration in peri-implant tissue (CD45<sup>+</sup>CD11b<sup>+</sup>Ly6C<sup>hi</sup>, <i>p</i> = 0.0019; CD45<sup>+</sup>CD11b<sup>+</sup>F4/80<sup>+</sup>, <i>p</i> = 0.0261), significantly reduced proinflammatory cytokine production (TNF-α, <i>p</i> = 0.0333; IL-6, <i>p</i> = 0.0194; IL-1β, <i>p</i> = 0.0090), and significant impaired osteoclast activity (TRAP<sup>+</sup> cells, <i>p</i> = 0.0240; RANKL, <i>p</i> = 0.0047), ultimately leading to attenuated mucosal inflammation and bone resorption in peri-implantitis. Moreover, treatment with bindarit demonstrated promising preventive and therapeutic effects in experimental peri-implantitis through inhibiting CCL2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings of this study suggest that CCL2 may serve as a potential target for peri-implantitis treatment by mediating peri-implant host immune response to modulate local inflammation and bone resorption, offering a new direction for the developmen","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1937-1948"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary NLRP3 inflammasome as a promising biomarker for palatal mucosa healing in diabetes mellitus: A pilot study","authors":"Manuela Maria Viana Miguel,&nbsp;Ana Carolina Ferreira Bonafé,&nbsp;Ingrid Fernandes Mathias-Santamaria,&nbsp;D. Travis Thomas,&nbsp;Luciana Macchion Shaddox,&nbsp;Mauro Pedrine Santamaria","doi":"10.1002/jper.70149","DOIUrl":"10.1002/jper.70149","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome is a protein complex that regulates IL-1β activation. Despite its known role in dermal healing, its involvement in oral mucosal healing remains poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-four subjects, including 12 with Type 2 diabetes mellitus (T2DM) and 12 normoglycemic controls (C), underwent a surgical procedure for mucogingival defect treatment in which a graft was harvested from the palate. The palatal wound was assessed for remaining wound area (RWA) and epithelialization (EPT) until 3 months. Wound exudate was collected on days 3 and 7 post-operatively to analyze inflammatory biomarkers, proteinases, and growth factors. NLRP3, PYCARD, CASPASE-1, and interleukin-1beta (IL-1β) salivary levels were assessed preoperatively and 7 days post-surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Lower EPT rates and greater RWA were observed in T2DM compared to Control on days 7 and 14 postoperatively. Higher MMP-9 concentration was detected in T2DM subjects on days 3 and 7 post-surgery (<i>p</i> &lt; 0.05). Salivary NLRP3 and PYCARD increased in the C group at 7 days post-surgery (<i>p</i> ≤ 0.04), whereas IL-1β was higher over time in the T2DM group (<i>p</i> = 0.003). At baseline, NLRP3 and PYCARD levels were higher in T2DM (<i>p</i> ≤ 0.005), whereas PYCARD (<i>p</i> = 0.01) and CASPASE-1 (<i>p</i> = 0.05) remained elevated at 7 days compared with C. A positive association between salivary NLRP3 levels with IL-1β (<i>r</i> = 0.46) and tumor necrosis factor-alpha (TNF-<i>α</i>) (<i>r</i> = 0.47) from wound exudate on day 7 was observed. PYCARD levels associated with IL-1β (<i>r</i> = 0.48) and TNF-<i>α</i> (<i>r</i> = 0.50) at the same time point. Principal component analysis of inflammasome-related markers and wound biomarkers on day 7 suggested a potential impact on delayed wound closure by day 14.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The NLRP3 inflammasome may be a promising biomarker for T2DM-related acute palatal healing due to its early upregulation and association with proinflammatory markers, with a potential impact on delayed wound closure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1924-1936"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning cone-beam computed tomography image segmentation for the 3D visualization of mandibular infraosseous periodontal defects","authors":"Daniel Palkovics,&nbsp;Balint Molnar,&nbsp;Csaba Pinter,&nbsp;David García-Mato,&nbsp;Andres Diaz-Pinto,&nbsp;Attila Tanacs,&nbsp;Andrea Dobos,&nbsp;Peter Windisch,&nbsp;Christoph A. Ramseier","doi":"10.1002/jper.70058","DOIUrl":"10.1002/jper.70058","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The accurate assessment of infraosseous periodontal defects is crucial for effective diagnosis and treatment planning. Cone-beam computed tomography (CBCT) enables detailed imaging of these defects; however, to leverage their full potential, CBCT images must be reconstructed in 3 dimensions (3D). Manual and semi-automatic (SA) segmentation methods are time-consuming and prone to human error. This study aimed to evaluate the performance of a deep learning (DL) model in segmenting mandibular infraosseous periodontal defects on CBCT scans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multi-stage Segmentation Residual Network (SegResNet)-based DL model was used to segment CBCT scans from patients with stages III to IV periodontitis. Linear and volumetric measurements of infraosseous defects from DL-generated 3D models were compared to those obtained using SA segmentation. The depth (INFRA), width (WIDTH), angle (ANGLE), and volume of 48 infraosseous defects were assessed on both DL and SA segmentations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Measurements made on the DL and SA segmentations correlated strongly. The intraclass correlation coefficient (ICC) was 0.941 (<i>p</i> &lt; 0.0001) for INFRA, 0.943 (<i>p</i> &lt; 0.0001) for WIDTH, 0.889 (<i>p</i> &lt; 0.0001) for ANGLE, and 0.948 (<i>p</i> &lt; 0.0001) for defect volume. These results indicate high reliability of the DL model in capturing key characteristics of infraosseous periodontal defects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings support the use of DL-based CBCT segmentation as a valuable tool for enhancing periodontal diagnosis. However, as this study was limited to mandibular defects, applicability to maxillary cases remains to be validated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1847-1859"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between vitamin C intake and gingival bleeding tendency in healthy, non‑deficient young adults","authors":"Thijs M. H. de Jong,&nbsp;Dagmar E. Slot,&nbsp;Cees Valkenburg,&nbsp;Bruno G. Loos,&nbsp;Fridus A. van der Weijden","doi":"10.1002/jper.70142","DOIUrl":"10.1002/jper.70142","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study is to investigate the relationship between reported vitamin C intake and gingival bleeding severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this cross-sectional study, 336 participants were screened, and 262 (118 females, 144 males) were eligible. Vitamin C intake was derived from the Food Frequency Questionnaire (FFQ). The body mass index (BMI), plaque index (PI), bleeding on marginal probing (BOMP), and bleeding on pocket probing (BOPP) were scored. Means and standard deviations (SD) were calculated overall and by sex. Spearman's correlations assessed links between vitamin C intake and clinical variables. Sex differences were analyzed using Fisher's exact test and the Mann-Whitney <i>U</i> test. Generalized regression models evaluated relationships between BOMP/BOPP and vitamin C intake, sex, age, and PI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The participants had a mean age of 22.6 years, mean BMI of 22.9 kg/m², and mean PI of 0.98. Average daily vitamin C intake was 108 mg (SD = 53), ranging from 19 to 425 mg. Mean BOMP and BOPP scores were 0.38 and 0.52, respectively. Regression models revealed no significant associations between vitamin C intake and BOMP or BOPP. However, PI was positively associated with both bleeding indices, while age was negatively associated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this non‑deficient young adult population, vitamin C intake was not significantly associated with gingival bleeding after adjusting for covariates. Gingival bleeding was positively associated with PI and negatively with age.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1910-1923"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal inflamed surface area (PISA) system and components: Potential for exploring the periodontal systemic interface","authors":"Sabrina C. Gomes,&nbsp;Kathleen Hovey,&nbsp;Michael LaMonte,&nbsp;Jean Wactawski-Wende,&nbsp;Marcelo W. B. Araujo","doi":"10.1002/jper.70151","DOIUrl":"10.1002/jper.70151","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The periodontal inflamed surface area (PISA) estimates the area of inflammatory burden of periodontal disease. This methodological study accessed PISA and its constituents, and systemic C-reactive protein correlations in an attempt to define different tools to investigate the periodontal-systemic interface.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Data from the Buffalo OsteoPerio cross-sectional study (1997–2001) were used. The full-mouth periodontal probing depth (PPD) and clinical attachment loss (CAL) at six sites per tooth, and marginal bleeding (MB) at three sites per tooth from 713 post-menopausal women were included. Fasting blood and saliva log-transformed C-reactive protein values were used.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A significant increase of MB (30 ± 20/43 ± 26), CAL (1.8 ± 0.3/3.1 ± 0.8), PPD (1.7 ± 0.2 /2.3 ± 0.4), PISA (220.5 ± 162.5/472.1 ± 324.6), and C-reactive protein (medians in mg/L), for saliva (0.43/0.67) and serum (2810/3882), was observed with increasing severity of periodontitis. Overall, the highest intercorrelations occurred for indices based on similar periodontal measures, as observed for PPD of whole mouth and of sites measured for bleeding (&lt;i&gt;r&lt;/i&gt; = 0.960). Correlations between PISA and C-reactive protein were weak for saliva [maximum of 0.088 (0.015, 0.161) and serum (maximum 0.048 (−0.027, 0.123)]. MB presented a consistent pattern of correlations with C-reactive protein, even weak [maximum of 0.254 (0.085, 0.409) for severe periodontitis]. For serum C-reactive protein, no significant correlations were found.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The extent of MB consistently correlated to C-reactive protein, while a higher correlation with PISA could not be determined. The results of the present investigation do not support the use of PISA as a clinical tool in place of, or adjuvant to, the extent of gingival bleeding present when exploring periodontal inflammation and its potential interface with systemic conditions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The diagnosis of periodontal disease may be performed using different tools. In this study, the authors tested a tool that evaluates the area of inflamed periodontium (PISA), and its components to evaluate the periodontal-systemic interface, using C-reactive protein as a marker of systemic inflammation. Interestingly, the percentage of sites positive for bleeding showed higher correlations with C-reactive protein than PISA. Although PISA has gained some followers, our","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"2013-2019"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148365192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of bioactive membrane in alveolar ridge preservation: A double-blind randomized clinical trial","authors":"Magdalena Orlowska,&nbsp;Muhammad H. A. Saleh,&nbsp;Ann Decker,&nbsp;Junying Li,&nbsp;Alice Ou,&nbsp;Nataly Zambrana,&nbsp;Paolo Nava,&nbsp;Fernanda A. da Costa Deller,&nbsp;Hom-Lay Wang","doi":"10.1002/jper.70094","DOIUrl":"10.1002/jper.70094","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This randomized controlled trial aims to evaluate alveolar ridge preservation (ARP) with or without a biologically active amnion–chorion membrane (BACM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty patients requiring tooth extraction in the esthetic zone were randomly assigned to 2 groups. Both groups underwent tooth extraction and collagenated bovine bone grafting, while the test sites received an additional BACM. Cone-beam computed tomography (CBCT) and intraoral scans (IOS) were performed before extraction and at 4 months post-extraction. Patient-reported outcomes (PROs) were assessed. The primary endpoint was the change in vertical and horizontal hard and soft tissue dimensions as measured by CBCT and clinically.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All patients completed implant placement. CBCT measurements at 2 mm demonstrated that control and test groups exhibited reductions in horizontal ridge width with median decreases of 1.19 mm and 2.41 mm, respectively, with no significant differences (<i>p</i> = 0.126). For vertical height changes, the control and test groups experienced mean reductions of 0.99 ± 1.08 mm and 1.33 ± 0.73 mm, respectively, with no significant differences (<i>p</i> = 0.250). IOS analyses showed that mean soft tissue thickness at the alveolar crest was 2.67 ± 0.699 mm (<i>p</i> = 0.370) in the control versus 2.13 ± 0.807 mm (<i>p</i> = 0.846) in the test group, with no significant differences (<i>p</i> = 0.325).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The addition of a BACM did not improve the mean horizontal or vertical bone dimentional changes or have a measurable effect on the soft tissue outcome during ARP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1871-1884"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging and periodontitis increase brain dissemination of oral bacteria","authors":"Ozge Unlu,&nbsp;Tsute Chen,&nbsp;Nil Yakar,&nbsp;Zeliha Guney,&nbsp;Bruce Paster,&nbsp;Isabel Carreras,&nbsp;Alpaslan Dedeoglu,&nbsp;Alpdogan Kantarci","doi":"10.1002/jper.70118","DOIUrl":"10.1002/jper.70118","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear. We hypothesized that aging increases the periodontitis-induced changes in the oral and systemic microbiome and is accompanied by an altered inflammatory response.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Experimental periodontitis was induced in 18-month-old (old) and 8-month-old (young) C57BL/6 mice by placing ligatures around the second maxillary molars. Bone morphometric analyses were conducted to assess bone loss. Senescence- and inflammatory-related gene expression in the gingiva was measured by quantitative polymerase chain reaction (qPCR). Serum inflammatory markers were evaluated via immunoassay. Oral, brain, and gut microbial content were analyzed using next-generation sequencing.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Maxillary bone loss was significantly higher in the old mice with periodontal disease than in young mice. Senescence and inflammatory markers were higher in old mice than in young ones, and periodontitis increased their expression. The alpha diversity of the oral and brain microbial communities differed significantly between old and young mice. &lt;i&gt;Treponema denticola&lt;/i&gt;, &lt;i&gt;Fusobacterium nucleatum, Porphyromonas gingivalis, P. pasteri&lt;/i&gt;, and &lt;i&gt;Prevotella nigrescens&lt;/i&gt; were only detected in the brains of old animals with periodontitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontopathogens and oral commensals are either only found in the brains of old animals with periodontal disease or are more prevalent in the brains of old animals, suggesting that aging and periodontitis may contribute to the dissemination of oral bacteria to the brain.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Aging may increase the periodontitis-induced changes in the oral and systemic microbiome, which an altered inflammatory response may accompany. Experimental periodontitis was created in old and young mouse models. Bone loss, senescence, and inflammatory gene expression and serum inflammatory markers were assessed in each model, and oral, brain, and gut microbial content was analyzed. Senescence and inflammatory markers were higher in old mice than in","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1965-1979"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grade C molar-incisor pattern periodontitis classification and its challenges","authors":"Yasmin Teixeira das Graças,&nbsp;Manuela Maria Viana Miguel,&nbsp;Renato Corrêa Viana Casarin,&nbsp;Mauro Pedrine Santamaria,&nbsp;Pratishtha Mishra,&nbsp;Luciana Macchion Shaddox","doi":"10.1002/jper.70119","DOIUrl":"10.1002/jper.70119","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The classification of periodontitis has changed, establishing not just the severity and extent of disease but also more comprehensive risk assessment for patients and hopefully guiding more tailored treatment approaches. Although the new classification presented several benefits to the severity and risk of progression of disease, some limitations remain. This review highlights key gaps in the grade C and molar-incisor pattern (C-MIP) classification, particularly the exclusion of primary dentition involvement, which limits early awareness, diagnosis, treatment, and research. Additionally, the current “grade C” category includes a broad spectrum of patients, ranging from systemically healthy young individuals with early onset and rapid disease progression to older adults whose disease is associated with modifying factors. This overlap masks key clinical and biological differences, complicating efforts to identify susceptibility profiles and tailor treatment. Moreover, cases extending beyond the molar-incisor pattern, including premolars or atypical presentations, pose challenges to the current classification system. These patients often exhibit early onset, familial aggregation, rapid progression, and absence of systemic risk factors, suggesting a unique susceptibility profile that may not be adequately captured by the current classification and deserve proper categorization to be better studied and treated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In the conclusion of this paper, we suggest expansion and clarification of the current classification system to: (1) recognize periodontitis in the primary dentition; (2) distinguish patients with grade C periodontitis by the presence or absence of modifying factors; and (3) introduce a subclassification for grade C cases predominantly affecting young patients. These refinements may improve diagnostic accuracy and support more targeted research, prevention, and treatment for at-risk youth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1885-1899"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding peri-implantitis occurrence and recurrence following treatment: A patient-centered study","authors":"Alberto Monje,&nbsp;Manal Sarsri Reffassi,&nbsp;Cristina Vallés,&nbsp;Ilyes Gourdache,&nbsp;Purnima Kumar,&nbsp;José Nart","doi":"10.1002/jper.70133","DOIUrl":"10.1002/jper.70133","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The present study aimed at gaining insight on patients´ perception of peri-implantitis and its treatment and also to explore the effect of treatment outcome on patients´ perception and satisfaction.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patients who had received peri-implantitis treatment were contacted and invited to participate in the questionnaire-based survey. Overall, 30 items were surveyed, including demographics, data concerning implant placement, diagnosis and signs/symptoms of peri-implantitis, level of education of disease, risk factors, knowledge of factors implicated in disease recurrence, and treatment delivered along with its self-perceived outcomes. Moreover, the treatment outcome was further recorded. Descriptive analyses and correlation tests were applied to explore association.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Based on an a priori sample size calculation, 100 patients with 258 implants subjected to peri-implantitis treatment were included. In total, 63% of the patients successfully responded to therapy displaying arrest in progressive bone loss, 26% demonstrated progressive bone loss (≥ 1 mm) and 11% were subjected to implant removal. The overall level of knowledge about peri-implantitis was moderately low, where ∼ 60% of the patients surveyed reported null knowledge about diagnosis, prevalence, or risk factors associated with disease occurrence, despite having received treatment of this disease. Compliers with supportive care demonstrated greater level of concern and knowledge regarding peri-implantitis and its recurrence. Patients were overall satisfied immediately (following therapy), at early (re-evaluation), and at late stages (during follow-up) with therapeutic outcomes of peri-implantitis, despite the therapeutic outcome achieved. In addition, patients accepted the possibility of disease recurrence and their role in minimizing it.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patient-reported information on factors related to peri-implantitis occurrence and recurrence is suboptimal. Nearly 60% of the patients are unaware of factors related to peri-implantitis ocurrence. However, peri-implantitis therapy does not seem to negatively interfere in the patients´ quality of life or satisfaction, despite the treatment outcomes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study examined how patients understand peri-implantitis and how they feel ab","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1980-1989"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Myron Nevins, DDS","authors":"","doi":"10.1002/jper.70172","DOIUrl":"10.1002/jper.70172","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1845-1846"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148717356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}