Journal of periodontology最新文献

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Palatal donor site wound healing following mucogingival surgery using amnion–chorion membrane: A randomized controlled clinical trial 使用羊膜-绒毛膜进行粘膜牙龈手术后腭供区伤口愈合:一项随机对照临床试验。
IF 4.5 2区 医学
Journal of periodontology Pub Date : 2026-09-11 Epub Date: 2026-06-18 DOI: 10.1002/jper.70147
Kylie J. Yineman, Archontia A. Palaiologou, Charles A. Powell, David E. Deas, Brian L. Mealey
{"title":"Palatal donor site wound healing following mucogingival surgery using amnion–chorion membrane: A randomized controlled clinical trial","authors":"Kylie J. Yineman,&nbsp;Archontia A. Palaiologou,&nbsp;Charles A. Powell,&nbsp;David E. Deas,&nbsp;Brian L. Mealey","doi":"10.1002/jper.70147","DOIUrl":"10.1002/jper.70147","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Free soft tissue autografts (FSTA) harvested from a patient's palate are frequently associated with significant postoperative morbidity. Several wound dressings have been applied to the palatal donor site with the aim of reducing postoperative complications and improving wound healing. Periodontal literature on the use of an amnion–chorion membrane (ACM) for this indication is limited, despite its antimicrobial, angiogenic, and anti-inflammatory properties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients requiring an autogenous soft tissue graft were randomized into receiving either an ACM or hemostatic agent (HA) palatal wound dressing following the harvest of an epithelialized FSTA. Early wound healing was assessed at 1, 2, 3, and 4 weeks following surgery using an Early Healing Index (EHI) that assessed bleeding on palpation, incomplete epithelialization, granulation tissue, inflammation, and redness. Postoperative questionnaires assessing a patient's pain level on a 21-point Numeric Rating Scale (NRS-21) and analgesic consumption over the first 72 h after the procedure were also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Healing improved significantly in both treatment groups over the study period. Over all 4 weeks, EHI scores were significantly higher in the ACM treatment group by 1.17 points (<i>p</i> = 0.027). There was no significant difference in NRS-21 scores or analgesics consumed between groups. Graft dimensions did not significantly affect either parameter assessed, but higher patient age was associated with higher EHI scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ACM resulted in improved early wound healing compared to HA when applied as a palatal donor site wound dressing following a FSTA harvest. Therefore, ACM may be an appropriate palatal wound dressing for patients with anticipated delayed healing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Trial Number</h3>\u0000 \u0000 <p>Clinicaltrials.gov NCT05400213</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 9","pages":"1900-1909"},"PeriodicalIF":4.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Double‐VISTA technique with connective tissue graft or acellular dermal matrix for treating multiple recessions associated with non‐carious cervical lesions: A retrospective study 双VISTA技术联合结缔组织移植物或脱细胞真皮基质治疗与非恶性宫颈病变相关的多发性衰退:一项回顾性研究
IF 4.3 2区 医学
Journal of periodontology Pub Date : 2026-08-31 DOI: 10.1002/jper.70190
Guo‐Hao Lin, Lan‐Lin Chiou, Yu‐Ting Yeh, Shayan Barootchi, Lorenzo Tavelli, Homayoun H. Zadeh, Hom‐Lay Wang
{"title":"Double‐VISTA technique with connective tissue graft or acellular dermal matrix for treating multiple recessions associated with non‐carious cervical lesions: A retrospective study","authors":"Guo‐Hao Lin, Lan‐Lin Chiou, Yu‐Ting Yeh, Shayan Barootchi, Lorenzo Tavelli, Homayoun H. Zadeh, Hom‐Lay Wang","doi":"10.1002/jper.70190","DOIUrl":"https://doi.org/10.1002/jper.70190","url":null,"abstract":"Background This retrospective study evaluated whether clinical outcomes differed between connective tissue graft (CTG) and allogeneic solvent‐dehydrated acellular dermal matrix (ADM) for treating multiple gingival recessions associated with non‐carious cervical lesions (NCCLs) using partial restoration and the double‐vestibular incision subperiosteal tunnel access (double‐VISTA) technique. Factors associated with complete recession coverage (CRC) were also analyzed. Methods Electronic health records from an academic institution were reviewed. Cases included three or more adjacent teeth with RT1 or RT2 recessions treated with CTG or ADM using the double‐VISTA technique and ≥12 months of follow‐up. The primary outcome was CRC. Secondary outcomes included recession depth (RD) reduction, percentage of RD reduction, keratinized tissue width (KTW) gain, Class I buccal furcation coverage, and Modified Root Coverage Esthetic Score (MRCES). Multivariate generalized estimating equations identified predictors of CRC. Results A total of 226 teeth from 36 patients met inclusion criteria. CRC was significantly higher with CTG than ADM (80.0% vs. 48.8%, &lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.001). CTG demonstrated greater RD reduction (2.57 ± 1.01 mm vs. 2.33 ± 0.77 mm, &lt;jats:italic&gt;p&lt;/jats:italic&gt; = 0.019), percentage of RD reduction (89.9% vs. 80.6%, &lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.001), KTW gain (0.39 ± 0.54 mm vs. 0.14 ± 0.35 mm, &lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.001), and MRCES. Class I buccal furcation coverage was more frequent with CTG than ADM (53.8% vs. 9.1%, &lt;jats:italic&gt;p&lt;/jats:italic&gt; = 0.028). RT1 defects, absence of Class I furcation involvement, thick gingival phenotype, and CTG as grafting material, were associated with CRC. Conclusion CTG provided more favorable CRC, RD reduction, KTW gain, MRCES, and Class I furcation coverage compared with ADM. CRC was strongly associated with baseline recession type, furcation involvement status, gingival phenotype, and grafting material used. Plain language summary This study looked at two commonly used soft tissue grafting materials for treating gum recession affecting multiple teeth, especially when teeth also had surface structure loss not caused by decay. The two materials compared were connective tissue graft (taken from the patient's hard palate) and a donated human‐derived tissue product. Both were used together with a surgical method called the double‐vestibular incision subperiosteal tunnel access (double‐VISTA) technique. Researchers reviewed dental records from a university clinic and analyzed outcomes from 226 teeth in 36 patients who were followed for at least 1 year. The main goal was to evaluate how often complete root coverage was achieved. Other outcomes included how much the gum recession improved, changes in gum thickness, and whether gum tissue successfully covered mild furcation defects in molars. Overall, connective tissue grafts showed better results than human‐derived tissues. Te","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"13 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction and risk factor analysis of dental implant failure using Cox regression and machine learning 基于Cox回归和机器学习的种植体失败预测及危险因素分析。
IF 4.5 2区 医学
Journal of periodontology Pub Date : 2026-08-24 Epub Date: 2026-02-28 DOI: 10.1002/jper.70112
In-Kyung Hwang, Soo Ho Ahn, Seong-Kyun Kim, Tae-Il Kim
{"title":"Prediction and risk factor analysis of dental implant failure using Cox regression and machine learning","authors":"In-Kyung Hwang,&nbsp;Soo Ho Ahn,&nbsp;Seong-Kyun Kim,&nbsp;Tae-Il Kim","doi":"10.1002/jper.70112","DOIUrl":"10.1002/jper.70112","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Survival analysis is commonly used to identify factors affecting dental implant longevity. While conventional studies typically employ the Cox proportional hazards model, the potential benefits of modern machine-learning algorithms remain unclear. In this study, we aimed to compare Cox regression with three machine-learning approaches—Random Survival Forest (RSF), DeepSurv, and TabNet—to evaluate their predictive performance and the risk factors they identify.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Clinical records of 543 implants placed in 256 patients were reviewed, with 32 failures observed over a mean follow-up of 8.0 ± 2.5  years. Cox models incorporating a patient-level frailty term were subjected to an exhaustive subset search. RSF, DeepSurv, and TabNet were tuned using 50 Optuna Bayesian trials, with the best settings refitted on a 90% training split and evaluated on the remaining 10%. Variable importance was assessed using hazard ratios for Cox regression and Shapley Additive Explanations for the machine-learning models.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The optimal Cox model achieved a concordance index (C-index) of 0.81 but demonstrated a limited area under the curve (AUC) performance. Among the machine-learning methods, RSF performed best (C-index, 0.72; AUC, 0.79; Integrated Brier Score, 0.044), outperforming DeepSurv and TabNet across all metrics. Both Cox regression and RSF identified anterior placement and periodontitis-related tooth loss as the primary risk factors for implant failure.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;RSF showed good, but not superior, predictive accuracy compared with the best-performing Cox model. The choice of analytical method for implant survival studies should consider model complexity in relation to the dataset's sample size and event rate.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Dental implants are a well-established treatment for replacing missing teeth; however, reports of associated complications are increasing. Identifying risk factors and estimating the likelihood of failure can assist clinicians in treatment planning and follow-up care. In this study, we analyzed 543 implants placed in 256 patients with disabilities, monitored over an average of 8 years, during which 32 implant failures occurred. We first developed traditional statistical models using Cox regression, a well-established method for survival analysis. Then, we evaluated three modern machine-learning models capable of handling time-to-event outco","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1703-1713"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlating bacterial load and periodontal disease severity: A large-scale study of the microbial landscape 相关细菌负荷和牙周病的严重程度:微生物景观的大规模研究。
IF 4.5 2区 医学
Journal of periodontology Pub Date : 2026-08-24 Epub Date: 2026-04-13 DOI: 10.1002/jper.70122
Naomi B. Gizaw, Nicholas Gomez, Ronald C. McGlennen, Mohammad-Zaman Nouri
{"title":"Correlating bacterial load and periodontal disease severity: A large-scale study of the microbial landscape","authors":"Naomi B. Gizaw,&nbsp;Nicholas Gomez,&nbsp;Ronald C. McGlennen,&nbsp;Mohammad-Zaman Nouri","doi":"10.1002/jper.70122","DOIUrl":"10.1002/jper.70122","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontitis is an inflammatory disease of the oral cavity driven by bacterial dysbiosis that progressively breaks down the tooth-supporting structures.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study leverages a uniquely large dataset of up to 34,000 patient records in the United States analyzed using standardized real-time polymerase chain reaction-based molecular testing to quantify bacterial profiles associated with periodontitis. Our analysis focused on 11 bacterial taxa from the red, orange, and green complexes. We assessed bacterial abundance, expressed as genome copies per milliliter, across periodontitis stages and associations with age and systemic conditions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Across stages 1–4 (according to the American Academy of Periodontology classification), the concentration of the three red complex bacteria, &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt;, &lt;i&gt;Tannerella forsythia&lt;/i&gt;, and &lt;i&gt;Treponema denticola&lt;/i&gt; increased up to 11-fold, the highest increase observed among all studied bacteria. A substantial microbial shift in younger patients was observed, while older individuals exhibited a higher prevalence of red complex pathogens. The relative abundance of &lt;i&gt;P. gingivalis&lt;/i&gt; increased significantly, from 4% in stage 1 periodontitis to 17% in stage 4. Cumulative bacterial load analysis based on the presence or absence of red complex bacteria revealed that the median bacterial load was 5-fold higher in samples where red complex bacteria were present. The inter-bacterial correlations increased with demographic and clinical variables as periodontitis advanced.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The findings revealed a significant positive association between increased bacterial loads, particularly red complex bacteria and higher periodontitis stages, positioning them as a key indicator of dysbiosis and a potential biomarker for disease advancement.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontitis is a serious gum disease that damages the tissues supporting the teeth. It is caused by harmful bacteria in the mouth and becomes worse over time if not treated. In this study, we analyzed oral rinse samples collected from more than 34,000 people using a DNA-based method to measure the levels of different bacteria. We focused on 11 bacteria known to be involved in gum disease and compared their presence in healthy versus mild to severe cases. We found that three bacteria, &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt;, &lt;i&gt;Tannerella forsythia&lt;/i&gt;, and","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1733-1745"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing the diagnosis of peri-implant diseases: From histological foundations to next-generation ultrasonographic diagnostic markers 推进种植体周围疾病的诊断:从组织学基础到下一代超声诊断标志物。
IF 4.5 2区 医学
Journal of periodontology Pub Date : 2026-08-24 Epub Date: 2026-04-13 DOI: 10.1002/jper.70113
Maria Elisa Galarraga-Vinueza, Jae-Kook Cha, Lorenzo Tavelli, Magda Feres
{"title":"Advancing the diagnosis of peri-implant diseases: From histological foundations to next-generation ultrasonographic diagnostic markers","authors":"Maria Elisa Galarraga-Vinueza,&nbsp;Jae-Kook Cha,&nbsp;Lorenzo Tavelli,&nbsp;Magda Feres","doi":"10.1002/jper.70113","DOIUrl":"10.1002/jper.70113","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This critical review provides a comprehensive analysis of the histological foundations, current clinical diagnostic standards, and emerging ultrasonographic methods for diagnosing peri-implant diseases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;An electronic search in Medline (PubMed) database was conducted to identify original and review articles focused on the histological foundation and diagnostic approaches of peri-implant diseases. This review provides an integrated perspective on the evolution of peri-implant diseases diagnostics, focusing on the clinical and radiographic criteria established by the latest consensus guidelines. It outlines the histological features of peri-implant diseases and discusses recent advancements in ultrasonographic imaging approaches for their characterization and diagnosis. This review further explores elements such as peri-implant anatomical landmarks, echo intensity, tissue perfusion, and strain elastography.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Histological studies have defined the peri-implant mucosal architecture and inflammatory patterns characteristic of disease progression. While conventional diagnostics have relied on clinical examination and radiographic imaging, high-frequency ultrasound (HFUS) has recently emerged as a promising noninvasive imaging tool enabling detailed assessment of peri-implant tissue dimensions, echo intensity, vascular perfusion, and the extent of inflammatory involvement. Echo intensity mapping aids in the visualization and quantification of peri-implant lesions and the identification of associated bone defects. These imaging advancements not only complement current diagnostic methods but also deepen our understanding of peri-implant disease dynamics. Observed correlations between histological findings and ultrasonographic features can support the development of a new diagnostic framework incorporating HFUS-derived markers for detecting peri-implant lesions and evaluating the severity of inflammation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Integrating HFUS and power Doppler imaging into peri-implant diagnostics allows real-time, noninvasive visualization of key structures such as the supracrestal adherent connective tissue, buccal bone levels, and tissue perfusion. These modalities can complement existing standards and enhance diagnostic precision by identifying the extent of peri-implant lesions and quantifying the severity of inflammation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Peri-implant disea","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1683-1702"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Memoriam: Terrence J. Griffin, DMD 纪念:特伦斯·j·格里芬,DMD
IF 4.5 2区 医学
Journal of periodontology Pub Date : 2026-08-24 Epub Date: 2026-05-13 DOI: 10.1002/jper.70139
{"title":"In Memoriam: Terrence J. Griffin, DMD","authors":"","doi":"10.1002/jper.70139","DOIUrl":"10.1002/jper.70139","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1619-1620"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148286398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-related local versus systemic early phase wound healing dynamics following free gingival graft harvest 游离牙龈移植术后与年龄相关的局部与全身早期伤口愈合动态
IF 4.5 2区 医学
Journal of periodontology Pub Date : 2026-08-24 Epub Date: 2026-02-19 DOI: 10.1002/jper.70089
Maayan Atzmon-Shavit, Marilena Vered, Michael Saminsky, Liat Chaushu
{"title":"Age-related local versus systemic early phase wound healing dynamics following free gingival graft harvest","authors":"Maayan Atzmon-Shavit,&nbsp;Marilena Vered,&nbsp;Michael Saminsky,&nbsp;Liat Chaushu","doi":"10.1002/jper.70089","DOIUrl":"10.1002/jper.70089","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Free palatal gingival grafts (FGG) are commonly harvested during mucogingival procedures. The present study investigates age-related local and systemic early secondary wound healing outcomes, following FGG harvest in a rat model.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A 4.2 mm diameter defect was created in the palate of 24 younger (2 m) and 24 older (6 m) Wistar male rats. They were divided according to experimental days 1–4. Values of complete blood count, chemistry analysis, and inflammatory biomarkers were assessed. Specimens were examined histologically.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Wound healing was similar between groups, with a significant de-epithelized surface reduction from day 1 to day 2 (&lt;i&gt;p&lt;/i&gt; = 0.0007) and day 2 to day 3 (&lt;i&gt;p&lt;/i&gt; = 0.002), without a significant difference between day 3 and day 4 (&lt;i&gt;p&lt;/i&gt; = 0.4). Histological inflammation scores were consistently higher in younger individuals, suggesting a more pronounced local inflammatory response. Picrosirius red staining revealed more dynamic collagen fiber organization in the younger rats, with significant differences at days 2 (&lt;i&gt;p &lt;/i&gt;= 0.01), 3 (&lt;i&gt;p &lt;/i&gt;= 0.03), and 4 (&lt;i&gt;p &lt;/i&gt;= 0.03). Age-related differences were noted regarding levels of WBC (white blood cells), RBC (red blood cells), HGB (hemoglobin), HCT (hematocrit), MCV (mean corpuscular volume), MCH (mean corpuscular hemoglobin), platelet counts, creatinine, SGPT (serum glutamic pyruvic transaminase), SGOT (serum glutamic-oxaloacetic transaminase), and AlkPhos. Younger rats displayed higher MCV, MCH, platelet counts, and a delayed rise in SGPT, creatinine, and AlkPhos over time, whereas older rats presented constantly higher WBC, RBC, HGB, HCT, and creatinine levels. Serum TNF-α levels were initially higher in the older rats but declined rapidly. In contrast, IL-6 peaked earlier and was higher in the older rats. IL-18 peaked earlier in the older (day 2) compared with the younger rats (day 3).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Local and systemic early events following surgery of the palatal mucosa revealed age-related differences. The older rats demonstrated in general a decreased local response vs. an increased systemic response.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Free palatal gingival grafts are commonly harvested during mucogingival procedures around teeth and implants. The present study investigated age-re","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1643-1658"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital and tomographic identification of risk indicators for gingival recession in the mandibular anterior region: A cross-sectional study 数字和断层识别在下颌前区牙龈衰退的危险指标:一项横断面研究。
IF 4.5 2区 医学
Journal of periodontology Pub Date : 2026-08-24 Epub Date: 2026-02-02 DOI: 10.1002/jper.70073
Gonzalo Blasi, Lise Maury, Lory Abrahamian, Youssra Abarchan, Behnam Taghavi, Jose Nart
{"title":"Digital and tomographic identification of risk indicators for gingival recession in the mandibular anterior region: A cross-sectional study","authors":"Gonzalo Blasi,&nbsp;Lise Maury,&nbsp;Lory Abrahamian,&nbsp;Youssra Abarchan,&nbsp;Behnam Taghavi,&nbsp;Jose Nart","doi":"10.1002/jper.70073","DOIUrl":"10.1002/jper.70073","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To assess clinical and anatomical risk indicators for mid-buccal gingival recessions (GRs) in the mandibular anterior region using digital and tomographic tools.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A cross-sectional study was conducted on 103 patients (618 teeth). Clinical examination, intraoral scanning, and cone-beam computed tomography (CBCT) were combined to record the keratinized tissue width (KTW), gingival phenotype, GR type (RT), probing pocket depth, clinical attachment level, recession depth (RD), tooth-ridge angulation, tooth malpositioning (TM), buccal bone thickness (BBT), buccal bone dehiscence (BBD), root prominence (RP), gingival thickness (GT), and papilla height (PH). Associations with GR were analyzed using multilevel regression with generalized estimation equations.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Gingival recession was observed in 70.9% of patients and 38.3% of teeth, most often RT2. Central incisors were most affected. Univariate analysis associated GR to age, tooth type, TM, reduced KTW, decreased BBT, increased BBD, and RT, while thicker phenotypes showed protective effects. Multivariable analysis confirmed five independent predictors: age, tooth type, TM (OR = 3.11), reduced KTW (OR = 0.64), and greater BBD (OR = 1.64). RD increased with age (+0.03 mm/year) and BBD (+0.21 mm).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Tooth malposition, inadequate KTW, and BBD are key risk indicators for gingival recession in the mandibular anterior region. Their identification is essential for preventive and therapeutic strategies.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Gingival recession, the apical migration of the gingival margin, is a common condition with implications for dental sensitivity, esthetics, and long-term periodontal health. The lower anterior region is particularly susceptible, yet the anatomical and clinical factors contributing to this vulnerability are not fully defined using digital tools. In this cross-sectional study of 103 patients (618 teeth), we integrated clinical examination, digital intraoral scanning, and CBCT to quantify soft and hard tissue characteristics. Recession was present in 70.9% of patients and 38.3% of teeth, predominantly affecting the central incisors. Multivariable analysis identified five independent risk indicators: older age, tooth type, tooth malposition, reduced keratinized tissue width, and buccal","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1621-1631"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictability of a dental implant prognosis system: A retrospective study 牙种植体预后系统的可预测性:一项回顾性研究。
IF 4.5 2区 医学
Journal of periodontology Pub Date : 2026-08-24 Epub Date: 2026-03-06 DOI: 10.1002/jper.70110
Kristen Young, Michelle Tong, Yu-Ting Yeh, Richard T. Kao, Guo-Hao Lin
{"title":"Predictability of a dental implant prognosis system: A retrospective study","authors":"Kristen Young,&nbsp;Michelle Tong,&nbsp;Yu-Ting Yeh,&nbsp;Richard T. Kao,&nbsp;Guo-Hao Lin","doi":"10.1002/jper.70110","DOIUrl":"10.1002/jper.70110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aimed to evaluate the predictability of the dental implant prognosis system proposed by Kwok et al. in 2023 by assessing implant survival rates across different initial prognosis categories over a 5-year period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were retrospectively collected from patients who received at least one dental implant from 2013–2022 at a single university-affiliated dental center. Eligible participants received baseline examinations at the time of implant-supported prosthesis delivery, with follow-up examinations at least 12 months after. Implants were categorized into favorable, questionable, unfavorable, and hopeless, based upon the prognosis categories proposed by Kwok et al. in 2023. Recorded measurements included: age, sex, follow-up duration, initial and latest implant prognoses, supportive care, history of grade C periodontitis, smoking, diabetes, and the use of intravenous bone sparing agents. Descriptive analysis was employed for data interpretation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study included 651 implants placed in 291 patients. Implants initially classified as having a favorable prognosis exhibited excellent long-term survivability, while those deemed unfavorable at baseline showed the greatest likelihood of deteriorating to a hopeless prognosis. At the latest follow-up, survival rates for implants initially categorized as favorable, questionable, and unfavorable were 100%, 93.5%, and 33.3%, respectively. Cox regression analysis identified initial prognosis, uncontrolled diabetes, and a history of grade C periodontitis as statistically significant risk factors for implant failure, with hazard ratios of 9.70, 35.14, and 66.48, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The dental implant prognosis system proposed by Kwok et al. is a reliable tool in assessing implant survivability within 5 years. Future research should investigate its long-term performance and the relationship between various influencing factors and implant prognosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1672-1682"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucogingival surgery techniques: Coronally advanced flap versus tunnel approach 粘膜牙龈手术技术:冠状进路皮瓣与隧道入路。
IF 4.5 2区 医学
Journal of periodontology Pub Date : 2026-08-24 Epub Date: 2026-03-23 DOI: 10.1002/jper.70116
Sofia Aroca, Giovanna Laura Di Domenico, Massimo de Sanctis
{"title":"Mucogingival surgery techniques: Coronally advanced flap versus tunnel approach","authors":"Sofia Aroca,&nbsp;Giovanna Laura Di Domenico,&nbsp;Massimo de Sanctis","doi":"10.1002/jper.70116","DOIUrl":"10.1002/jper.70116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mucogingival surgery techniques for treating gingival recessions (GRs) have evolved significantly over decades, reflecting advances in surgical understanding and patient demands. This narrative review <span>traces</span>examines the historical development of the coronally advanced flap–multiple coronally advanced flap (CAF/MCAF) and tunnel techniques, highlighting how these procedures have been refined to improve clinical outcomes and esthetic results. Emphasis is placed on the biological principles underlying these approaches and their adaptation based on growing scientific evidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive review of the literature was conducted, synthesizing historical milestones and recent clinical studies including randomized controlled trials and systematic reviews. The focus was on comparing the CAF and tunnel approaches in terms of surgical principles, technical variations, and effectiveness in root coverage treatment, considering adjunctive use of grafting materials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both the CAF/MCAF and tunnel techniques demonstrate high predictability and effectiveness in GR coverage. Their evolution reflects a trend toward minimally invasive surgery, improved vascularization, and tissue stability. Current evidence supports the choice of technique based on defect characteristics, tissue phenotype, and esthetic requirements, with connective tissue grafts (CTGs) and biomaterials enhancing outcomes in many cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Both CAF and tunnel techniques provide predictable root coverage, enhanced by CTGs (gold standard) or substitutes (reducing morbidity but with limited evidence). The choice between the two techniques should be guided by recession and tissue phenotype characteristics to optimize functional and esthetic outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>This study highlights the history and development of two key mucogingival surgical techniques, the coronally advanced flap and the tunnel technique, demonstrating that both provide reliable and effective options for treating gingival recessions, enabling successful root coverage outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1714-1732"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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