Journal of periodontology最新文献

{"title":"Mucogingival surgery techniques: Coronally advanced flap versus tunnel approach","authors":"Sofia Aroca,&nbsp;Giovanna Laura Di Domenico,&nbsp;Massimo de Sanctis","doi":"10.1002/jper.70116","DOIUrl":"10.1002/jper.70116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mucogingival surgery techniques for treating gingival recessions (GRs) have evolved significantly over decades, reflecting advances in surgical understanding and patient demands. This narrative review <span>traces</span>examines the historical development of the coronally advanced flap–multiple coronally advanced flap (CAF/MCAF) and tunnel techniques, highlighting how these procedures have been refined to improve clinical outcomes and esthetic results. Emphasis is placed on the biological principles underlying these approaches and their adaptation based on growing scientific evidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive review of the literature was conducted, synthesizing historical milestones and recent clinical studies including randomized controlled trials and systematic reviews. The focus was on comparing the CAF and tunnel approaches in terms of surgical principles, technical variations, and effectiveness in root coverage treatment, considering adjunctive use of grafting materials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both the CAF/MCAF and tunnel techniques demonstrate high predictability and effectiveness in GR coverage. Their evolution reflects a trend toward minimally invasive surgery, improved vascularization, and tissue stability. Current evidence supports the choice of technique based on defect characteristics, tissue phenotype, and esthetic requirements, with connective tissue grafts (CTGs) and biomaterials enhancing outcomes in many cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Both CAF and tunnel techniques provide predictable root coverage, enhanced by CTGs (gold standard) or substitutes (reducing morbidity but with limited evidence). The choice between the two techniques should be guided by recession and tissue phenotype characteristics to optimize functional and esthetic outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>This study highlights the history and development of two key mucogingival surgical techniques, the coronally advanced flap and the tunnel technique, demonstrating that both provide reliable and effective options for treating gingival recessions, enabling successful root coverage outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1714-1732"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between self-reported oral symptoms and irritable bowel syndrome: A prospective cohort study based on UK Biobank","authors":"Zhuoya Sun,&nbsp;Laifu Li,&nbsp;Yan Zhuang,&nbsp;Xiaoting Hu,&nbsp;Jiamiao Chen,&nbsp;Shiwei Lu,&nbsp;Fei Dai","doi":"10.1002/jper.70125","DOIUrl":"10.1002/jper.70125","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Although periodontal disease (PD) has been linked to an increased risk of several gastrointestinal diseases such as inflammatory bowel disease and celiac disease, research on the association between PD and irritable bowel syndrome (IBS) is still insufficiently explored, with conflicting results. We aimed to investigate the potential association between self-reported oral symptoms and IBS based on the UK Biobank cohort.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Oral symptoms were assessed via questionnaire. Participants reporting at least one of gum pain, gum bleeding, or loose teeth were classified as being at high risk of PD. The primary outcome was incident IBS. Cox proportional hazards regression, incorporating multiple covariates, was applied to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) in examining the links between oral symptoms, high PD risk, and IBS incidence. Subgroup and sensitivity analyses were conducted.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This longitudinal cohort study was conducted among 420,371 participants, 8642 incident cases of IBS (2.1%) were identified. Cox regression analyses showed that several oral symptoms, including mouth ulcers, gum pain, gum bleeding, toothache, and denture use, were significantly associated with an increased risk of IBS. No significant association was observed between loose teeth and IBS in any model. Compared with the low PD risk group, individuals at high risk of PD had an elevated likelihood of IBS onset (HR = 1.19, 95% CI: 1.13–1.25). Subgroup and sensitivity analyses strengthened the validity of these findings.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Oral symptoms (mouth ulcers, gum pain, gum bleeding, toothache, and denture use) and high risk of PD were both associated with an increased incidence of IBS. Incorporating oral health management into comprehensive strategies may contribute to the prevention of IBS.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;There is a close connection between oral health and gut health. This long-term study of more than 420,000 UK adults found that individuals experiencing mouth ulcers, gum pain, gum bleeding, toothache, or denture use had a higher risk of developing irritable bowel syndrome (IBS) later in life. Additionally, participants classified as being at high risk for periodontal disease (PD; those with at least one symptom of gum pain, gum bleeding, or loose teeth) had about a 19% higher risk of developing IBS compared with the low PD risk group. Therefore, inco","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1819-1829"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of simple predictive models of tooth loss in the community setting","authors":"Michiko Furuta,&nbsp;Takanori Honda,&nbsp;Shinya Kageyama,&nbsp;Nanami Sawada,&nbsp;Satoko Sakata,&nbsp;Jun Hata,&nbsp;Toshiharu Ninomiya,&nbsp;Toru Takeshita","doi":"10.1002/jper.70074","DOIUrl":"10.1002/jper.70074","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A simple tool for predicting the risk of tooth loss is considered valuable for the implementation of early preventive measures in community settings. This study aimed to establish a simple predictive model for tooth loss in a community-dwelling Japanese population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This longitudinal study included 1755 participants aged 40–79 years who underwent dental examinations between 2007 and 2012. Incident tooth loss was defined as losing ≥2 teeth over a 5-year period, corresponding to the highest quartile of the number of teeth lost. Logistic regression analysis was employed for developing multivariate prediction models with and without dental examination data. The developed models were translated into simplified scoring systems based on the beta coefficients. The discrimination of the model was assessed using the Hosmer–Lemeshow test, and the calibration was assessed using a calibration plot.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The incidence of tooth loss was 24.1%. The multivariable model without dental examination data, which included age, current smoking, diabetes, periodontal treatment, number of teeth present, and occupational status as predictors, demonstrated good discrimination and calibration. The multivariable model with dental examination parameters (periodontitis stage and untreated decayed teeth) as predictors demonstrated better predictive performance. The simplified scores, which were developed based on multivariable models, demonstrated predictive performances comparable to that of their respective multivariable models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The prediction model, even the model without dental examination data can be used to identify individuals at high risk for tooth loss. The simple scoring tool for predicting tooth loss can be readily implemented in the community.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Plain language summary</h3>\u0000 \u0000 <p>We developed a multivariable risk prediction model and simplified scoring system for predicting tooth loss, which may help in the identification of individuals at a high risk of tooth loss in a community.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1795-1806"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach","authors":"Ramona Ramalho de Souza Pereira,&nbsp;Caíque Olegário Diniz e Magalhães,&nbsp;Elizabeth Luciana Marinho Miguel,&nbsp;Larissa Vieira Toledo,&nbsp;Débora Ribeiro Orlando,&nbsp;Alan Rodrigues Teixeira Machado,&nbsp;Bruno Del Bianco Borges,&nbsp;Luciano José Pereira,&nbsp;Marco Fabrício Dias-Peixoto,&nbsp;Eric Francelino Andrade","doi":"10.1002/jper.70069","DOIUrl":"10.1002/jper.70069","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear. Thus, we aimed to investigate metabolite alterations in the hippocampus and amygdala of rats subjected to ligature-induced PD.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Twenty-four male Wistar rats were randomly allocated into PD and Sham groups (&lt;i&gt;n&lt;/i&gt; = 12/group). Periodontitis was induced by placing a ligature around the mandibular first molars for 14 days. After euthanasia, histomorphometric analyses of alveolar bone loss, epithelial thickness, and inflammatory cell count were performed to confirm the effectiveness of the periodontitis induction, and the hippocampus and amygdala were subsequently collected for &lt;sup&gt;1&lt;/sup&gt;H NMR-based metabolomic analysis. Metabolites were identified and quantified, and data were analyzed using orthogonal partial least squares discriminant analysis (OPLS-DA).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The OPLS-DA revealed distinct metabolite profiles in both the hippocampus and amygdala of animals with periodontitis. In the hippocampus, acetate and glycerol levels were decreased, while myo-inositol and creatine levels were elevated. In the amygdala, increased concentrations of isoleucine and glycine were observed. These metabolic alterations are consistent with mechanisms related to neuroinflammation, oxidative stress, cognitive dysfunction, and anxiety-like behavior.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Ligature-induced periodontitis leads to specific metabolic disturbances in brain regions responsible for memory and emotional processing. These findings support a potential neurobiological link between periodontitis and central nervous system dysfunction.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;While periodontitis has been associated with neuroinflammation and behavioral impairments, the specific metabolic changes in central nervous system structures such as the hippocampus and amygdala remain poorly understood. This study identified altered metabolite profiles in the hippocampus and amygdala of rats with ligature-induced periodontitis, involving compounds associated with neuroinflammatory pathways and behavioral dysfunctions. These findings provide novel insig","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1773-1783"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145955339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting peri-implantitis incidence and implant failure via risk-assessment and prognostication tools: A validation study","authors":"Muhammad H. A. Saleh,&nbsp;Era Kakar,&nbsp;Giuseppe Troiano,&nbsp;Hamzeh Almashni,&nbsp;Jonathan Misch,&nbsp;Fariba Esperouz,&nbsp;Shahad Alhazmi,&nbsp;Hom-Lay Wang,&nbsp;Zoltán Baráth,&nbsp;Istvan A. Urban","doi":"10.1002/jper.70047","DOIUrl":"10.1002/jper.70047","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Identifying individuals at high risk for developing peri-implantitis (PI) and then determining the prognosis for implants with PI is crucial for treatment planning.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study longitudinally followed implants from implant placement retrospectively. The peri-implant disease risk assessment (IDRA) tool was applied, and the performance of the Kwok and Caton (KC) implant prognostication tool was compared with that of a new tool based on the frequency of progressive bone loss (PBL). The predictive accuracy of IDRA, PBL, and KC was evaluated at the corresponding time points (T1–T5). Fisher's exact test was used to evaluate categorical variables, and the Mann-Whitney test was used to evaluate continuous variables. Multiple regression models were built to correlate the occurrence of peri-implantitis and implant survival. The study followed the OHstat and TRIPOD guidelines for reporting.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;146 dental implants in 87 patients were included (age = 63.19 ± 11.38 years). IDRA classified the implants as 85.62% high-, 14.38% moderate-, and 0% low-risk. The KC scores showed 7.53% of implants with a favorable-, 65.07% with a questionable-, and 27.4% with an unfavorable prognosis. IDRA showed limited predictive power with an AUC of 0.533 (95% CI: 0.477–0.590). The KC tool performed much better, where a score of 2 had an AUC of 0.8321 (95% CI: 0.7257–0.9386). PBL yielded a moderate but consistent effectiveness with an AUC of 0.7697 (95% CI: 0.593–0.9463).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The KC and PBL prognostication tools exhibited good predictive capability for implant survival, while the IDRA tool demonstrated marginal efficacy in predicting the incidence of peri-implantitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this study, we followed 87 patients with 146 implants over time to test how well different tools can predict implant health and survival. We tested three tools, IDRA for predicting peri-implantitis, the KC system, and a new tool based on progressive bone loss for predicting implant survival. After 2 years with the implant crowns in place, we checked for cases of peri-implantitis. At the final follow-up (up to 8 years), the implant survival was assessed. We found that IDRA was not effective in predicting which implants developed peri-implantitis, even in high- and moderate-risk implants.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1784-1794"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145830266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional tooth unit, periodontal status, and association with weight change in older adults","authors":"Mariana S. Muñoz,&nbsp;Natália M. Pola,&nbsp;Juliana B. Hilgert,&nbsp;Fernando N. Hugo,&nbsp;Roberto P. Pimentel,&nbsp;Eleanor M. Simonsick,&nbsp;Francisco W. M. G. Muniz","doi":"10.1002/jper.70100","DOIUrl":"10.1002/jper.70100","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Literature reports that having fewer teeth is associated with reduced chewing capacity, which in turn may lead to weight changes due to diminished oral functionality. This study aims to assess the association between functional tooth units (FTU) and periodontal status and weight change among older adults participating in the Health, Aging, and Body Composition Study (Health ABC).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study followed individuals with complete data on weight at years 2 and 6 of Health ABC. Variables included the number of teeth, FTU, and periodontal status, which were considered the primary exposures. The main outcome was a weight change of at least 5% during the follow-up period. Multinomial regression was used to calculate the odds ratio (OR) associated with at least 5% weight change. Independent adjusted models were built for each primary exposure (α &lt; 5%).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The study included 903 participants, of whom 231 (25.6%) experienced weight loss and 104 (11.5%) experienced weight gain. No significant association was found between weight loss and any of the exposures (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). However, weight gain was associated with clinical attachment loss (CAL), number of teeth (OR: 0.97; 95%CI: 0.94–0.99), FTU/molars (OR: 0.83; 95%CI: 0.70–0.98), FTU/posterior (OR: 0.92; 95%CI: 0.84–0.99), and FTU/total (OR: 0.95; 95%CI: 0.91–0.99).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Tooth loss was associated with weight gain over 4 years. Additional research is needed to uncover underlying mechanisms, including food choice.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Researchers studied how tooth loss and gum health affect weight changes in older adults. They followed participants from the Health, Aging, and Body Composition Study for 4 years, looking at their teeth, chewing ability, and weight changes.&lt;/p&gt;\u0000 \u0000 &lt;p&gt;Out of 903 people in the study, 231 (25.6%) lost weight, and 104 (11.5%) gained weight. The results showed that having fewer teeth and poor gum health did not significantly affect weight loss. However, weight gain was linked to tooth loss and gum problems. People with fewer teeth or weaker chewing ability were more likely to gain weight.&lt;/p&gt;\u0000 \u0000 &lt;p&gt;The study suggests that losing teeth may lead to changes in eating habits that result in weight gain. However, more re","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1807-1818"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of testosterone and high-dose anabolic steroids on orthodontic-induced bone remodeling and root resorption: An animal study","authors":"Caio Luiz Bitencourt Reis,&nbsp;Kelly Galisteu-Luiz,&nbsp;Gabriela Leite Pedroso,&nbsp;Gustavo Lopes Puls,&nbsp;Leticia Cassaro,&nbsp;Bruno Boaventura Vieira,&nbsp;Fábio Lourenço Romano,&nbsp;Erika Calvano Küchler,&nbsp;Christian Kirschneck,&nbsp;Daniela Silva Barroso de Oliveira,&nbsp;Maria Bernadete Sasso Stuani,&nbsp;Mirian Aiko Nakane Matsumoto","doi":"10.1002/jper.70068","DOIUrl":"10.1002/jper.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Testosterone deficiency was induced through orchiectomy, and the anabolic-androgenic steroid (AAS, testosterone undecanoate) was administered in both replacement and high doses. OTM was simulated using a closed-coil spring on the maxillary right first molar. The surrounding tissues—alveolar bone and periodontal ligament—of both the moved tooth and the contralateral (control) tooth were analyzed 5 and 10 days post-OTM using micro-CT, reverse-transcription quantitative polymerase chain reaction (RT-qPCR), and immunohistochemistry. Root resorption, testosterone, and adrenocorticotropic hormone plasmatic levels were also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both testosterone deficiency and high-dose AAS lead to significant changes in bone microarchitecture, resulting in reduced trabecular thickness, decreased bone connectivity, and bone lacunae. Testosterone dysfunction was associated with greater rotation and intrusion of the moved tooth. High-dose AAS intensified the inflammatory infiltrate and root resorption. Moreover, testosterone dysfunction altered the expression of key genes involved in bone metabolism, including Runx2, Bmp2, Spp1, and Bglap. The Rank/Rankl/Opg pathway was also deregulated due to testosterone disturbances. AAS at replacement doses did not normalize the inflammatory infiltrate, OTM, and the expression of the studied genes to control levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Testosterone dysfunction whether from deficiency or high-dose AAS exposure negatively impacts OTM, increasing bone resorption and promoting inflammation, potentially leading to long-term consequences for bone health and periodontal support. AAS at replacement doses may also impact PDL and bone during OTM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1758-1772"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and local factors associated with radiographic bone loss in primary dentition: A retrospective study","authors":"Murilo C. Paraluppi,&nbsp;Camila S. Stolf,&nbsp;Bianca Mendes,&nbsp;Marcio Z. Casati,&nbsp;Karina G. Silvério,&nbsp;Enilson A. Sallum,&nbsp;Renato C. V. Casarin,&nbsp;Mabelle F. Monteiro","doi":"10.1002/jper.70075","DOIUrl":"10.1002/jper.70075","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aimed to evaluate the radiographic bone level in primary molars in a Brazilian population, define the prevalence of bone loss, and identify the local factors associated with early bone alterations.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Radiographs of children who attended Piracicaba Dental School (Brazil) between 2014 and 2020 were evaluated. Two calibrated examiners measured the distance between the cementoenamel junction and the bone crest (CEJ-BC) in bitewing radiographs, and CEJ-BC &gt; 2 mm represented bone loss. Local factors in the measured sites were screened. Multiple linear and logistic regressions were used in the analysis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;828 bitewing radiographs from 527 patients (8.27 ± 1.71 years) were evaluated. The mean CEJ-BC distance was 1.12 ± 0.40 mm (0.0–3.4 mm). 85 sites were positive for bone loss, with a prevalence of 2.62% at site and 13.28% (70 individuals) at patient levels. Male patients, increasing age, maxilla, first primary molars, and local factors were related to a higher CEJ-BC. Pulpectomies, fillings, and adjacent tooth eruption were positively associated with bone loss, and those statistically significant local factors were present in 42.4% of the sites with bone loss.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The prevalence of radiographic bone alterations in primary molars was 13.28%. The CEJ-BC distance and bone loss were positively associated with local factors (58.8% of the cases); however, 41.2% of the sites positive for bone loss did not present the local factors evaluated in this study.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Clinical relevance&lt;/h3&gt;\u0000 \u0000 &lt;div&gt;\u0000 &lt;ol&gt;\u0000 \u0000 &lt;li&gt;\u0000 &lt;p&gt;&lt;b&gt;Scientific rationale for this study&lt;/b&gt;: Bone loss can be present in children and adolescents, and radiographic evaluation could help to elucidate its prevalence and the factors associated with its occurrence.&lt;/p&gt;\u0000 &lt;/li&gt;\u0000 \u0000 &lt;li&gt;\u0000 &lt;p&gt;&lt;b&gt;Principal findings&lt;/b&gt;: A prevalence of 13.28% bone loss was found at the patient level in primary molars in a Brazilian population, and local factors were positively associated with bone alterations. Despite some cases diagnosed with bone loss being related to local factors, 41.2% had no association with the local risk factors evaluated in the study.&lt;/p&gt;\u0000 ","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1632-1642"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsupervised phenotyping of the periodontal architecture through high-dimensional clustering of electronic health records: A multicenter study","authors":"Georgios S. Chatzopoulos,&nbsp;Larry F. Wolff","doi":"10.1002/jper.70123","DOIUrl":"10.1002/jper.70123","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To identify novel periodontal phenotypes using unsupervised machine learning on a large-scale, multicenter cohort, specifically characterizing disease patterns based on the “periodontal architecture” of localized structural failures (tooth mobility and molar furcation defects) rather than global severity averages alone.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This cross-sectional study analyzed electronic health records from 15,723 adult patients with periodontitis. A high-dimensional feature vector (&lt;i&gt;D&lt;/i&gt; = 72) was constructed for each patient, integrating tooth-specific ordinal grades for mobility and furcation, mean probing depths (PPD), clinical attachment loss (CAL), and systemic health variables. Unsupervised phenotyping was performed using principal component analysis (PCA), t-SNE visualization, and &lt;i&gt;K&lt;/i&gt;-means clustering. Cluster validity was assessed via Silhouette Analysis, and phenotypes were compared using ANOVA and Chi-square (&lt;i&gt;X&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;) tests.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Four distinct architectural phenotypes were identified: (1) Maintenance/Healthy, representing stability; (2) Anterior–Mobility dominant, defined by high-grade anterior mobility (52.4% prevalence), and the highest diabetes prevalence (12.2%); (3) Molar-Furcation Dominant, a male-dominated group (61%) characterized by advanced posterior furcation defects (93.8% prevalence) despite lower anterior mobility; and (4) Generalized severe, exhibiting global architectural collapse. The phenotypes demonstrated statistically significant separation across all clinical metrics (&lt;i&gt;p&lt;/i&gt; &lt; 0.001).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontitis manifests as distinct architectural archetypes—specifically “Anterior–Mobility” and “Molar-Furcation” phenotypes—that are often aggregated into a single severity category by traditional staging. These data-driven clusters have unique systemic risk profiles, suggesting that diagnosis and treatment planning should incorporate the specific localization of structural failure.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Severe gum disease (periodontitis) is traditionally classified by overall severity, often grouping different types of tooth damage into the same broad category. To uncover hidden patterns, we used an artificial intelligence technique to analyze the detailed dental and medical records of more than 15,000 patients. Inst","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1746-1757"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the subgingival HerBiome and HisBiome over the human healthspan","authors":"Rahul Nikam,&nbsp;Kazune Pax,&nbsp;Michelle Lee-Scott Beverly,&nbsp;Purnima S. Kumar","doi":"10.1002/jper.70098","DOIUrl":"10.1002/jper.70098","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Understanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age-related oral and systemic diseases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Subgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years. 16S amplicon sequencing was performed. 80 million sequences were annotated and analyzed through the QIIME pipeline, principal components analysis (PCA) used for dimensionality reduction, LefSe to identify driver species, beta dispersion to measure inter-subject variability, and machine learning algorithm (&lt;i&gt;RandomForest&lt;/i&gt; package in R [RF]) to validate the results. Causal mediation models were implemented to investigate the influence of aging on the male and female microbiomes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;PCA demonstrated significant class separation based on sex (&lt;i&gt;p &lt;&lt;/i&gt; 0.001, permutational multivariate analysis of variance [PERMANOVA]). Males demonstrated higher alpha diversity (&lt;i&gt;p &lt;&lt;/i&gt; 0.001, Wilcoxon signed-rank test of the Shannon diversity index), but also higher inter-subject heterogeneity &lt;i&gt;p &lt;&lt;/i&gt; 0.001, ANOVA). RF identified males with 0.99 sensitivity, 0.15 specificity, and accuracy of 85%. Age exerted an almost complete mediation effect, with significant differences in the trajectory and pattern of aging between males and females. Females &gt; 30 demonstrated a lower microbial diversity (&lt;i&gt;p &lt;&lt;/i&gt; 0.001) and higher levels of &lt;i&gt;Fusobacterium nucleatum&lt;/i&gt; (&lt;i&gt;p &lt;&lt;/i&gt; 0.001), while the male microbiome remained highly personalized throughout the lifespan, without defined patterns of aging.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Sex and age interact to influence the subgingival microbiome. These findings might explain differing disease susceptibilities in either sex, as well as informing personalized prevention and intervention based on age and sex. Further studies using granular -omics approaches are needed to advance our knowledge.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Plain language summary&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Periodontal (gum) diseases are caused by a breakdown in the intricate balance between bacteria that live under the gumline and the local immune response. Since periodontal diseases have been reported to be more common in men than in women, we set out to investigate whether these bacterial communities a","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"97 8","pages":"1659-1671"},"PeriodicalIF":4.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jper.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}