Journal of NeuroVirology最新文献

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Herpesvirus initiation of dementias and autoimmune diseases. 疱疹病毒引发痴呆和自身免疫性疾病。
IF 1.9 4区 医学
Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-07-07 DOI: 10.1007/s13365-025-01265-8
Kevin Roe
{"title":"Herpesvirus initiation of dementias and autoimmune diseases.","authors":"Kevin Roe","doi":"10.1007/s13365-025-01265-8","DOIUrl":"10.1007/s13365-025-01265-8","url":null,"abstract":"<p><p>Several viral, bacterial, fungal, and protozoan parasite pathogens are capable of causing either active and/or latent chronic infections, particularly if they are highly immuno-evasive. The nine human herpesviruses are among the most evasive pathogens. They can remain latent for decades, but can periodically reactivate into active chronic infections after various triggers: medical treatments causing intentional or unintentional immune system suppression, other pathogen infections, malnutrition, stress, or unusual host cell signaling. Various neurological disorders including dementias and severe autoimmune diseases have been linked to highly prevalent human herpesvirus infections including herpes simplex type 1 and 2, varicella-zoster virus, Epstein-Barr virus, human cytomegalovirus, and herpesviruses 6A, 6B, 7 and 8. For example, dementias including Alzheimer's disease have been extensively linked to herpes simplex type 1 and 2, and herpesvirus 6A and 7, but other herpesviruses may be indirectly involved in dementias. For instance, recent evidence strongly suggests dementias can result from reactivated varicella-zoster herpes virus infections, whereas effective vaccinations against varicella-zoster herpes virus reactivations to avoid shingles have also shown significant reductions in dementia probabilities for vaccinated individuals. This raises questions about how various herpesviruses can initiate or enable neurological diseases including dementias and autoimmune diseases, and how their infections and particularly their reactivations from latency can initiate these diseases.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"305-332"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific mitochondrial DNA changes in neuron-derived extracellular vesicles of African American adults: impact of HIV infection and smoking. 非裔美国成年人神经元源性细胞外囊泡的性别特异性线粒体DNA变化:HIV感染和吸烟的影响
IF 1.9 4区 医学
Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-07-25 DOI: 10.1007/s13365-025-01272-9
Vladimir Berthaud, Tarik Smith, Venkateswara R Amara, Derek Wilus, Franklin J Nouvet, Waldemar Popik
{"title":"Sex-specific mitochondrial DNA changes in neuron-derived extracellular vesicles of African American adults: impact of HIV infection and smoking.","authors":"Vladimir Berthaud, Tarik Smith, Venkateswara R Amara, Derek Wilus, Franklin J Nouvet, Waldemar Popik","doi":"10.1007/s13365-025-01272-9","DOIUrl":"10.1007/s13365-025-01272-9","url":null,"abstract":"<p><p>Mitochondrial DNA (mtDNA) in extracellular vesicles (EVs) may track HIV-related neuronal injury. We measured mtDNA copy number in neuron-derived EVs (NEVs) and total plasma EVs from 48 African American adults stratified by sex, HIV status, and smoking. NEV-mtDNA differed by group (p < 0.05): men with HIV showed the highest levels, markedly exceeding HIV-negative men and all women, while smoking raised NEV-mtDNA only in men. Plasma EV-mtDNA paralleled NEVs but was ~ 100-fold higher, reflecting systemic release. These sex-specific increases implicate HIV as a stronger mitochondrial stressor in men and support NEV-mtDNA as a convenient biomarker of neuro-mitochondrial dysfunction.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"389-394"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Guillain-Barré syndrome and SARS-CoV-2 virus infection, including the impact of COVID-19 vaccination in the context of the development and general clinical characteristics of the disease. 格林-巴罗综合征与SARS-CoV-2病毒感染之间的关系,包括COVID-19疫苗接种对该疾病发展和一般临床特征的影响
IF 1.9 4区 医学
Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-07-07 DOI: 10.1007/s13365-025-01267-6
Jakub Sadowski, Joanna Huk, Sylwia Otulak, Jesica Zawiło, Tomasz Klaudel, Mateusz Roszak, Dominik Tenczyński, Rafał Jakub Bułdak
{"title":"Association between Guillain-Barré syndrome and SARS-CoV-2 virus infection, including the impact of COVID-19 vaccination in the context of the development and general clinical characteristics of the disease.","authors":"Jakub Sadowski, Joanna Huk, Sylwia Otulak, Jesica Zawiło, Tomasz Klaudel, Mateusz Roszak, Dominik Tenczyński, Rafał Jakub Bułdak","doi":"10.1007/s13365-025-01267-6","DOIUrl":"10.1007/s13365-025-01267-6","url":null,"abstract":"<p><p>During the COVID-19 pandemic, a statistically significant increase in the incidence of Guillain-Barré syndrome (GBS) has begun to be observed. This article discusses the impact of immunological processes on structural and functional changes in the peripheral nervous system on the pathogenesis of GBS. The aim of the systematic review is to analyze and discuss available information from the scientific literature regarding a possible clinical relationship between SARS-CoV-2 infection along with vaccination mainly, adenovector and mRNA vaccines and the development of different types of Guillain-Barré syndrome. The review specifically discusses the role of proinflammatory cytokines and \"cytokine storm\" in patients with COVID-19 and their potential impact on the phenomenon of \"molecular mimicry\" and the generation of autoantibodies in GBS. This issue has been expanded to include information from studies on the impact of vaccination against SARS-CoV-2 virus and the higher number of observed cases of Guillain-Barré syndrome. Focusing on the characteristics of the methods, materials, results and conclusions, the review finally included 114 publications, like studies, meta-analyses, clinical cases and reviews. The systematic review was conducted using PubMed, Google Scholar, and Elsevier databases. It pointed out the molecular and clinical association between SARS-CoV-2 virus infections and COVID-19 vaccination, in the development of Guillain-Barré syndrome in the context of its clinical course.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"333-346"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrative analysis reveals human endogenous retroviruses-linked immune signatures in schizophrenia. 综合分析揭示了精神分裂症患者的内源性逆转录病毒相关免疫特征。
IF 1.9 4区 医学
Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1007/s13365-025-01260-z
Mohammad Karimzadeh, Faranak Zakizadeh, Farah Bokharaei-Salim, Victoria Omranifard, Soroor Kiani, Mohammad Hossein Razizadeh
{"title":"Integrative analysis reveals human endogenous retroviruses-linked immune signatures in schizophrenia.","authors":"Mohammad Karimzadeh, Faranak Zakizadeh, Farah Bokharaei-Salim, Victoria Omranifard, Soroor Kiani, Mohammad Hossein Razizadeh","doi":"10.1007/s13365-025-01260-z","DOIUrl":"10.1007/s13365-025-01260-z","url":null,"abstract":"<p><p>Schizophrenia is a complex psychiatric disorder with multifactorial etiologies, including genetic components. The role of Human endogenous retroviruses has been suggested in schizophrenia pathogenesis. This study aims to identify and analyze the shared genetic components between schizophrenia and Human endogenous retroviruses through bioinformatics approaches. Genes associated with schizophrenia and Human endogenous retroviruses were identified and analyzed for overlap. A protein-protein interaction network was constructed, followed by hub gene selection using various algorithms. Functional enrichment analyses were conducted to determine biological processes and pathways involved. Transcription factors and miRNA networks were built to investigate gene regulation. Drug and chemical interactions were examined, and gene-disease associations were assessed. Also, gene expression levels in different brain regions and brain and blood cells were analyzed. Logistic regression analysis was done to evaluate the association of hub genes with schizophrenia. A total of 345 genes were found common between schizophrenia and Human endogenous retroviruses. Six hub genes (AKT1, CD4, CD8A, IL6, STAT1, and TNF) were identified. Gene ontology and pathway analyses indicated immune system involvement. Gene expression analysis showed differential expression patterns in blood and brain cells. IL6 and TNF were significantly upregulated in schizophrenia patients, while AKT1 exhibited downregulation. Logistic regression revealed IL6 and TNF as risk factors, whereas AKT1 showed protective effects. This study found key genetic interactions between schizophrenia and endogenous human retroviruses, with hub genes playing significant roles in immune signaling and neuroinflammation. These findings introduce potential targets for therapeutic interventions in schizophrenia.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"347-362"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Limited HIV-associated neuropathologies and lack of immune activation in sub-saharan African individuals with late-stage subtype C HIV-1 infection". 评论“撒哈拉以南非洲晚期C亚型HIV-1感染个体中有限的hiv相关神经病变和缺乏免疫激活”。
IF 1.9 4区 医学
Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-07-22 DOI: 10.1007/s13365-025-01269-4
Hinpetch Daungsupawong, Viroj Wiwanitkit
{"title":"Comment on \"Limited HIV-associated neuropathologies and lack of immune activation in sub-saharan African individuals with late-stage subtype C HIV-1 infection\".","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1007/s13365-025-01269-4","DOIUrl":"10.1007/s13365-025-01269-4","url":null,"abstract":"","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"395-396"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metformin promotes PEN2 expression to attenuate microglia-mediated neurotoxicity induced by HIV-1 Tat. 二甲双胍促进PEN2表达以减轻HIV-1 Tat诱导的小胶质细胞介导的神经毒性。
IF 1.9 4区 医学
Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-06-04 DOI: 10.1007/s13365-025-01263-w
Ya Shen, Tianli Xu, Yezi Sun, Kelun Zhang, Xiaojun Cao, Limin Shen, Mengjie Tang
{"title":"Metformin promotes PEN2 expression to attenuate microglia-mediated neurotoxicity induced by HIV-1 Tat.","authors":"Ya Shen, Tianli Xu, Yezi Sun, Kelun Zhang, Xiaojun Cao, Limin Shen, Mengjie Tang","doi":"10.1007/s13365-025-01263-w","DOIUrl":"10.1007/s13365-025-01263-w","url":null,"abstract":"<p><p>Metformin, a first-line drug used to treat type 2 diabetes mellitus (T2DM), also reduces neuroinflammation and improves motor and cognitive outcomes. Metformin binds to presenilin enhancer 2 (PEN2) and further enhances its therapeutic benefits. The mechanisms of HIV-associated neurocognitive disorders (HANDs) remain unclear. HIV-1 trans-activator of transcription (Tat) contributes to neurotoxicity in HAND. We revealed that PEN2 expression decreased markedly in HAND patients and Tat-infected microglia. Metformin (200 µM) treatment significantly reduced Tat-induced decreases in cell viability, oxidative stress, the proinflammatory response and excessive glutamate and iNOS release and had neuroprotective effects. Tat subsequently increased NF-κB activity, which was prominently suppressed during treatment. In addition, PEN2 knockdown in microglia dramatically reversed the neuroprotective effect of metformin against Tat. Our findings indicate that metformin binds PEN2 and modulates microglia-mediated HIV-1 Tat neurotoxicity in HAND.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"376-388"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time since HIV diagnosis is linked to amnestic mild cognitive impairment (MCI) in older adults with HIV. 自HIV诊断以来的时间与老年HIV感染者的遗忘性轻度认知障碍(MCI)有关。
IF 2.3 4区 医学
Journal of NeuroVirology Pub Date : 2025-07-18 DOI: 10.1007/s13365-025-01271-w
Jason S DeFelice, Mark K Britton, Yancheng Li, Eric C Porges, Gladys E Ibañez, Charurut Somboonwit, Robert L Cook, Ronald A Cohen, Joseph M Gullett
{"title":"Time since HIV diagnosis is linked to amnestic mild cognitive impairment (MCI) in older adults with HIV.","authors":"Jason S DeFelice, Mark K Britton, Yancheng Li, Eric C Porges, Gladys E Ibañez, Charurut Somboonwit, Robert L Cook, Ronald A Cohen, Joseph M Gullett","doi":"10.1007/s13365-025-01271-w","DOIUrl":"https://doi.org/10.1007/s13365-025-01271-w","url":null,"abstract":"<p><p>Aging people with HIV (PWH) may be at heightened risk of Mild Cognitive Impairment (MCI), including the subtypes amnestic MCI (aMCI) and non-amnestic MCI (naMCI). We examined associations between putative risk factors (HIV clinical variables, lifetime substance exposure, APOE genotype) and clinician consensus-defined MCI status in older PWH. Additionally, we evaluated agreement between clinician consensus aMCI and algorithmic (Jak-Bondi) aMCI classification, as well as overlap between aMCI and HIV-Associated Neurocognitive Disorder (HAND). PWH (N = 56; median age 63; IQR 61-67) completed a neurocognitive battery. Two neuropsychologists assigned consensus diagnoses (aMCI/naMCI/no MCI). Alcohol, cocaine, opioid, and cannabis exposure, years since HIV diagnosis, and time from diagnosis to care were assessed by self-report. APOE was genotyped from whole blood. HIV viral load (detectable/undetectable) was assayed from plasma. Algorithmic aMCI classification was made using modified Jak-Bondi criteria and HAND classification using Frascati criteria. 36% of participants (N = 20) met consensus aMCI criteria. aMCI status was significantly associated with years since HIV diagnosis, time to care, and opioid exposure in age-adjusted models. However, MCI status was not associated with alcohol, cocaine, or cannabis exposure, APOE genotype, or detectable viral load. Agreement between clinician consensus and algorithmic aMCI classification was substantial. Participants with aMCI and naMCI (vs. no MCI) were significantly more likely to meet HAND criteria. Because time since diagnosis and time from diagnosis to care were associated with amnestic MCI in PWH, greater cumulative HIV exposure may be linked to greater neuropathology in aging.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing a cellular MicroRNA-based approach to silence bat-borne Nipah virus genes. 设计一种基于细胞微rna的方法来沉默蝙蝠传播的尼帕病毒基因。
IF 2.3 4区 医学
Journal of NeuroVirology Pub Date : 2025-07-07 DOI: 10.1007/s13365-025-01268-5
Nikita Kar, Supriyo Chakraborty
{"title":"Designing a cellular MicroRNA-based approach to silence bat-borne Nipah virus genes.","authors":"Nikita Kar, Supriyo Chakraborty","doi":"10.1007/s13365-025-01268-5","DOIUrl":"https://doi.org/10.1007/s13365-025-01268-5","url":null,"abstract":"<p><p>The bat-borne Nipah virus, known for causing high mortality rates in humans, has been reported in India (Megaderma spasma), Bangladesh (Pteropus medius), and Malaysia (Pteropus vampyrus) with different bat species serving as reservoirs. The virus also infects various animals, which often act as intermediate hosts in the transmission to humans. Due to the high fatality rates associated with Nipah virus outbreaks, the World Health Organization has flagged it as a significant public health concern, prompting extensive research into the development of antiviral therapeutics and vaccines. However, no effective vaccine or therapeutic agent has yet been established. In this context, we propose a miRNA-based approach to identify key human cellular miRNAs capable of binding to and potentially cleaving or degrading Nipah virus genes implicated in human infections. Our study revealed a substantial number of miRNA binding sites across various viral genes, suggesting a potential mechanism for gene silencing. Furthermore, the calculated free energy values (< 4 kcal/mol) for all three regions; downstream, upstream and target indicate that the thermodynamically favorable binding could facilitate effective miRNA-mediated repressions of viral gene expression. Additionally, the translational efficiency and COSM values suggested swift miRNA-mediated cleavage or degradation of the viral genes. Moreover, analysis of the miRNA-mRNA duplex free energy and secondary structures, as predicted by RNAFold, indicated that the interactions between human miRNAs and Nipah virus genes were thermodynamically stable. These stable duplex formations support the potential for efficient binding, leading to effective gene silencing through cleavage or degradation mechanisms.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic significance of miR-34c-5p in patients with postherpetic neuralgia and its correlation with rehabilitation effect. miR-34c-5p在疱疹后神经痛患者中的诊断意义及其与康复效果的相关性。
IF 1.9 4区 医学
Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1007/s13365-025-01264-9
Xiaojun Zhou, Huan Ding, Bin Wang, Hui Kang
{"title":"Diagnostic significance of miR-34c-5p in patients with postherpetic neuralgia and its correlation with rehabilitation effect.","authors":"Xiaojun Zhou, Huan Ding, Bin Wang, Hui Kang","doi":"10.1007/s13365-025-01264-9","DOIUrl":"10.1007/s13365-025-01264-9","url":null,"abstract":"<p><strong>Background: </strong>Postherpetic neuralgia (PHN) represents the most prevalent and distressing complication of shingles. The aim of this study was to explore the diagnostic significance of miR-34c-5p in PHN patients and to assess its correlation with rehabilitation effect.</p><p><strong>Methods: </strong>This study enrolled 154 PHN patients and 108 healthy participants as research subjects. RT-qPCR was used to detect serum miR-34c-5p levels in the participants. ROC curve was employed to estimate the diagnostic significance of miR-34c-5p in PHN patients. Logistic regression analysis was performed to analyze the risk factors related to the occurrence of PHN. VAS, TEX-Q and HADS scales were filled in by questionnaires to analyze the rehabilitation effect of PHN patients after treatment. Spearman correlation analysis was applied to evaluate the relationship of miR-34c-5p levels with rehabilitation effect in treated PHN patients.</p><p><strong>Results: </strong>miR-34c-5p levels were notably elevated in PHN patients compared to healthy participants. miR-34c-5 had a high sensitivity (79.2%) and specificity (84.3%) to distinguish between healthy individuals and PHN patients. Logistic regression analysis indicated that miR-34c-5p emerged as an independent risk factor for the development of PHN. miR-34c-5p levels, VAS, TEX-Q, HADS-A and HADS-D scores were reduced in prednisone-treated PHN patients compared to the basic treatment group. In addition, Spearman correlation suggested that miR-34c-5p levels were positively correlated with VAS, TEX-Q, HADS-A and HADS-D scores.</p><p><strong>Conclusion: </strong>miR-34c-5p exhibited the ability to diagnose PHN and may be a biomarker for diagnosis of this disease. Moreover, reduced miR-34c-5p expression in PHN patients correlate with enhanced outcomes in rehabilitation.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"295-301"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender dependent modulation of opioid dependance genes and signaling pathways in HIV-1 Transgenic rats at morphine tolerance. HIV-1转基因大鼠吗啡耐受性中阿片依赖基因和信号通路的性别依赖调节。
IF 1.9 4区 医学
Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1007/s13365-025-01257-8
Muhammed Bishir, Wenfei Huang, Ilker K Sariyer, Sulie L Chang
{"title":"Gender dependent modulation of opioid dependance genes and signaling pathways in HIV-1 Transgenic rats at morphine tolerance.","authors":"Muhammed Bishir, Wenfei Huang, Ilker K Sariyer, Sulie L Chang","doi":"10.1007/s13365-025-01257-8","DOIUrl":"10.1007/s13365-025-01257-8","url":null,"abstract":"<p><p>Misuse of opioids is a major comorbidity in people with HIV (PWH). Neurological abnormalities and opioid addiction seen in PWH involve the interplay among signaling pathways. However, the impact of HIV proteins on morphine dependence is understudied. We aimed to understand the modulation of the opioid dependence genes and signaling pathways in the striatum (Str) and prefrontal cortex (PFC) of PWH. HIV-1 transgenic (HIV-1Tg) rats and F344 control animals were given 2 and 4 pellets of morphine (75-mg/pellet)/placebo on Days 1 and 2, respectively, via subcutaneous implantation. On Day 5, at morphine tolerance the rats were sacrificed, Str and PFC were collected for RNA isolation and cDNA preparation. A PCR-array was used to examine the expression of the 65 opioid dependance genes. Varying numbers of genes were significantly upregulated in the Str and PFC of morphine treated rats. Fold change values were uploaded to QIAGEN Ingenuity Pathway Analysis, to study the signaling pathways associated with the treatment conditions. CREB signaling in neurons and Neuroinflammation signaling pathway were highly activated in the Str of both male and female HIV-1Tg rats given morphine. Gαq signaling and S100 family signaling were activated in female HIV-1Tg rats received morphine. Similarly, in the PFC, synthesis of IP3, CREB Signaling in neurons, Gαq signaling in males and CREB Signaling in neuron, and Gαq signaling in females were activated. Using bioinformatic analysis, we identified key signaling pathways and gender dependent changes in the opioid dependent gene expression and pathway enrichment of HIV-1Tg rats at morphine tolerance.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"262-286"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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