Journal of NeuroVirology最新文献_第2页

Comment on "Limited HIV-associated neuropathologies and lack of immune activation in sub-saharan African individuals with late-stage subtype C HIV-1 infection". 评论“撒哈拉以南非洲晚期C亚型HIV-1感染个体中有限的hiv相关神经病变和缺乏免疫激活”。

IF 1.9 4区医学

Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-07-22 DOI: 10.1007/s13365-025-01269-4

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Metformin promotes PEN2 expression to attenuate microglia-mediated neurotoxicity induced by HIV-1 Tat. 二甲双胍促进PEN2表达以减轻HIV-1 Tat诱导的小胶质细胞介导的神经毒性。

IF 1.9 4区医学

Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-06-04 DOI: 10.1007/s13365-025-01263-w

Ya Shen, Tianli Xu, Yezi Sun, Kelun Zhang, Xiaojun Cao, Limin Shen, Mengjie Tang

{"title":"Metformin promotes PEN2 expression to attenuate microglia-mediated neurotoxicity induced by HIV-1 Tat.","authors":"Ya Shen, Tianli Xu, Yezi Sun, Kelun Zhang, Xiaojun Cao, Limin Shen, Mengjie Tang","doi":"10.1007/s13365-025-01263-w","DOIUrl":"10.1007/s13365-025-01263-w","url":null,"abstract":"Metformin, a first-line drug used to treat type 2 diabetes mellitus (T2DM), also reduces neuroinflammation and improves motor and cognitive outcomes. Metformin binds to presenilin enhancer 2 (PEN2) and further enhances its therapeutic benefits. The mechanisms of HIV-associated neurocognitive disorders (HANDs) remain unclear. HIV-1 trans-activator of transcription (Tat) contributes to neurotoxicity in HAND. We revealed that PEN2 expression decreased markedly in HAND patients and Tat-infected microglia. Metformin (200 µM) treatment significantly reduced Tat-induced decreases in cell viability, oxidative stress, the proinflammatory response and excessive glutamate and iNOS release and had neuroprotective effects. Tat subsequently increased NF-κB activity, which was prominently suppressed during treatment. In addition, PEN2 knockdown in microglia dramatically reversed the neuroprotective effect of metformin against Tat. Our findings indicate that metformin binds PEN2 and modulates microglia-mediated HIV-1 Tat neurotoxicity in HAND.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"376-388"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time since HIV diagnosis is linked to amnestic mild cognitive impairment (MCI) in older adults with HIV. 自HIV诊断以来的时间与老年HIV感染者的遗忘性轻度认知障碍（MCI）有关。

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-07-18 DOI: 10.1007/s13365-025-01271-w

Jason S DeFelice, Mark K Britton, Yancheng Li, Eric C Porges, Gladys E Ibañez, Charurut Somboonwit, Robert L Cook, Ronald A Cohen, Joseph M Gullett

{"title":"Time since HIV diagnosis is linked to amnestic mild cognitive impairment (MCI) in older adults with HIV.","authors":"Jason S DeFelice, Mark K Britton, Yancheng Li, Eric C Porges, Gladys E Ibañez, Charurut Somboonwit, Robert L Cook, Ronald A Cohen, Joseph M Gullett","doi":"10.1007/s13365-025-01271-w","DOIUrl":"https://doi.org/10.1007/s13365-025-01271-w","url":null,"abstract":"Aging people with HIV (PWH) may be at heightened risk of Mild Cognitive Impairment (MCI), including the subtypes amnestic MCI (aMCI) and non-amnestic MCI (naMCI). We examined associations between putative risk factors (HIV clinical variables, lifetime substance exposure, APOE genotype) and clinician consensus-defined MCI status in older PWH. Additionally, we evaluated agreement between clinician consensus aMCI and algorithmic (Jak-Bondi) aMCI classification, as well as overlap between aMCI and HIV-Associated Neurocognitive Disorder (HAND). PWH (N = 56; median age 63; IQR 61-67) completed a neurocognitive battery. Two neuropsychologists assigned consensus diagnoses (aMCI/naMCI/no MCI). Alcohol, cocaine, opioid, and cannabis exposure, years since HIV diagnosis, and time from diagnosis to care were assessed by self-report. APOE was genotyped from whole blood. HIV viral load (detectable/undetectable) was assayed from plasma. Algorithmic aMCI classification was made using modified Jak-Bondi criteria and HAND classification using Frascati criteria. 36% of participants (N = 20) met consensus aMCI criteria. aMCI status was significantly associated with years since HIV diagnosis, time to care, and opioid exposure in age-adjusted models. However, MCI status was not associated with alcohol, cocaine, or cannabis exposure, APOE genotype, or detectable viral load. Agreement between clinician consensus and algorithmic aMCI classification was substantial. Participants with aMCI and naMCI (vs. no MCI) were significantly more likely to meet HAND criteria. Because time since diagnosis and time from diagnosis to care were associated with amnestic MCI in PWH, greater cumulative HIV exposure may be linked to greater neuropathology in aging.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing a cellular MicroRNA-based approach to silence bat-borne Nipah virus genes. 设计一种基于细胞微rna的方法来沉默蝙蝠传播的尼帕病毒基因。

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-07-07 DOI: 10.1007/s13365-025-01268-5

Nikita Kar, Supriyo Chakraborty

{"title":"Designing a cellular MicroRNA-based approach to silence bat-borne Nipah virus genes.","authors":"Nikita Kar, Supriyo Chakraborty","doi":"10.1007/s13365-025-01268-5","DOIUrl":"https://doi.org/10.1007/s13365-025-01268-5","url":null,"abstract":"The bat-borne Nipah virus, known for causing high mortality rates in humans, has been reported in India (Megaderma spasma), Bangladesh (Pteropus medius), and Malaysia (Pteropus vampyrus) with different bat species serving as reservoirs. The virus also infects various animals, which often act as intermediate hosts in the transmission to humans. Due to the high fatality rates associated with Nipah virus outbreaks, the World Health Organization has flagged it as a significant public health concern, prompting extensive research into the development of antiviral therapeutics and vaccines. However, no effective vaccine or therapeutic agent has yet been established. In this context, we propose a miRNA-based approach to identify key human cellular miRNAs capable of binding to and potentially cleaving or degrading Nipah virus genes implicated in human infections. Our study revealed a substantial number of miRNA binding sites across various viral genes, suggesting a potential mechanism for gene silencing. Furthermore, the calculated free energy values (< 4 kcal/mol) for all three regions; downstream, upstream and target indicate that the thermodynamically favorable binding could facilitate effective miRNA-mediated repressions of viral gene expression. Additionally, the translational efficiency and COSM values suggested swift miRNA-mediated cleavage or degradation of the viral genes. Moreover, analysis of the miRNA-mRNA duplex free energy and secondary structures, as predicted by RNAFold, indicated that the interactions between human miRNAs and Nipah virus genes were thermodynamically stable. These stable duplex formations support the potential for efficient binding, leading to effective gene silencing through cleavage or degradation mechanisms.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic significance of miR-34c-5p in patients with postherpetic neuralgia and its correlation with rehabilitation effect. miR-34c-5p在疱疹后神经痛患者中的诊断意义及其与康复效果的相关性。

IF 1.9 4区医学

Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1007/s13365-025-01264-9

Xiaojun Zhou, Huan Ding, Bin Wang, Hui Kang

{"title":"Diagnostic significance of miR-34c-5p in patients with postherpetic neuralgia and its correlation with rehabilitation effect.","authors":"Xiaojun Zhou, Huan Ding, Bin Wang, Hui Kang","doi":"10.1007/s13365-025-01264-9","DOIUrl":"10.1007/s13365-025-01264-9","url":null,"abstract":"Background: Postherpetic neuralgia (PHN) represents the most prevalent and distressing complication of shingles. The aim of this study was to explore the diagnostic significance of miR-34c-5p in PHN patients and to assess its correlation with rehabilitation effect.Methods: This study enrolled 154 PHN patients and 108 healthy participants as research subjects. RT-qPCR was used to detect serum miR-34c-5p levels in the participants. ROC curve was employed to estimate the diagnostic significance of miR-34c-5p in PHN patients. Logistic regression analysis was performed to analyze the risk factors related to the occurrence of PHN. VAS, TEX-Q and HADS scales were filled in by questionnaires to analyze the rehabilitation effect of PHN patients after treatment. Spearman correlation analysis was applied to evaluate the relationship of miR-34c-5p levels with rehabilitation effect in treated PHN patients.Results: miR-34c-5p levels were notably elevated in PHN patients compared to healthy participants. miR-34c-5 had a high sensitivity (79.2%) and specificity (84.3%) to distinguish between healthy individuals and PHN patients. Logistic regression analysis indicated that miR-34c-5p emerged as an independent risk factor for the development of PHN. miR-34c-5p levels, VAS, TEX-Q, HADS-A and HADS-D scores were reduced in prednisone-treated PHN patients compared to the basic treatment group. In addition, Spearman correlation suggested that miR-34c-5p levels were positively correlated with VAS, TEX-Q, HADS-A and HADS-D scores.Conclusion: miR-34c-5p exhibited the ability to diagnose PHN and may be a biomarker for diagnosis of this disease. Moreover, reduced miR-34c-5p expression in PHN patients correlate with enhanced outcomes in rehabilitation.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"295-301"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender dependent modulation of opioid dependance genes and signaling pathways in HIV-1 Transgenic rats at morphine tolerance. HIV-1转基因大鼠吗啡耐受性中阿片依赖基因和信号通路的性别依赖调节。

IF 1.9 4区医学

Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1007/s13365-025-01257-8

Muhammed Bishir, Wenfei Huang, Ilker K Sariyer, Sulie L Chang

{"title":"Gender dependent modulation of opioid dependance genes and signaling pathways in HIV-1 Transgenic rats at morphine tolerance.","authors":"Muhammed Bishir, Wenfei Huang, Ilker K Sariyer, Sulie L Chang","doi":"10.1007/s13365-025-01257-8","DOIUrl":"10.1007/s13365-025-01257-8","url":null,"abstract":"Misuse of opioids is a major comorbidity in people with HIV (PWH). Neurological abnormalities and opioid addiction seen in PWH involve the interplay among signaling pathways. However, the impact of HIV proteins on morphine dependence is understudied. We aimed to understand the modulation of the opioid dependence genes and signaling pathways in the striatum (Str) and prefrontal cortex (PFC) of PWH. HIV-1 transgenic (HIV-1Tg) rats and F344 control animals were given 2 and 4 pellets of morphine (75-mg/pellet)/placebo on Days 1 and 2, respectively, via subcutaneous implantation. On Day 5, at morphine tolerance the rats were sacrificed, Str and PFC were collected for RNA isolation and cDNA preparation. A PCR-array was used to examine the expression of the 65 opioid dependance genes. Varying numbers of genes were significantly upregulated in the Str and PFC of morphine treated rats. Fold change values were uploaded to QIAGEN Ingenuity Pathway Analysis, to study the signaling pathways associated with the treatment conditions. CREB signaling in neurons and Neuroinflammation signaling pathway were highly activated in the Str of both male and female HIV-1Tg rats given morphine. Gαq signaling and S100 family signaling were activated in female HIV-1Tg rats received morphine. Similarly, in the PFC, synthesis of IP3, CREB Signaling in neurons, Gαq signaling in males and CREB Signaling in neuron, and Gαq signaling in females were activated. Using bioinformatic analysis, we identified key signaling pathways and gender dependent changes in the opioid dependent gene expression and pathway enrichment of HIV-1Tg rats at morphine tolerance.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"262-286"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system. 纠正：抗逆转录病毒药物诱导中枢神经系统氧化应激和神经元损伤。

IF 1.9 4区医学

Journal of NeuroVirology Pub Date : 2025-06-01 DOI: 10.1007/s13365-025-01266-7

Cagla Akay, Michael Cooper, Akinleye Odeleye, Brigid K Jensen, Michael G White, Fair Vassoler, Patrick J Gannon, Joseph Mankowski, Jamie L Dorsey, Alison M Buch, Stephanie A Cross, Denise R Cook, Michelle-Marie Peña, Emily S Andersen, Melpo Christofidou-Solomidou, Kathryn A Lindl, M Christine Zink, Janice Clements, R Christopher Pierce, Dennis L Kolson, Kelly L Jordan-Sciutto

引用次数: 0

Clinic-radiological classification of herpesviral encephalitis in humans (systematic review). 人类疱疹病毒性脑炎的临床-放射学分类（系统综述）。

IF 1.9 4区医学

Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-04-19 DOI: 10.1007/s13365-025-01250-1

Dmytro Maltsev

{"title":"Clinic-radiological classification of herpesviral encephalitis in humans (systematic review).","authors":"Dmytro Maltsev","doi":"10.1007/s13365-025-01250-1","DOIUrl":"10.1007/s13365-025-01250-1","url":null,"abstract":"The development of a comprehensive classification for herpesvirus encephalitis remains an urgent task. Distinct clinic-radiological forms of herpesvirus cerebral lesions have been characterized, including findings from histopathological studies. Differences among these forms have been demonstrated concerning key clinical and paraclinical parameters. The presented classification identifies several distinct forms of herpesvirus encephalitis: temporal, brainstem, limbic, diencephalic encephalitis, rhombencephalitis, leukoencephalitis, ventriculoencephalitis, diffuse glial micronodular encephalitis, subcortical and cortical encephalitis, cerebellitis, neonatal encephalitis. Additionally, the concepts of combined, coexisting and multimodal lesions are introduced to describe complex forms of herpesvirus neuroinfections. The use of the term \"specific spectrum of herpesvirus cerebral lesions\" is supported. Both the phenomena of specificity and universality are considered. Fundamental differences between the forms of herpesvirus encephalitis are highlighted with respect to their prevalence within the population, etiological factors, clinical manifestations, typical complications, recovery completeness, mortality rates, immune status. The distinctive diagnostic and therapeutic approaches required for each form of herpesvirus encephalitis are emphasized. The integration of this classification into clinical practice has the potential to optimize medical care for patients with herpesvirus encephalitis, enabling not only etiologically-oriented but also form-specific approaches to treatment.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"219-241"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential effects of fentanyl compared to morphine on neuroinflammatory signaling in the brain in EcoHIV-infected mice. 芬太尼与吗啡对ecohiv感染小鼠大脑中神经炎症信号的不同影响

IF 1.9 4区医学

Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-05-30 DOI: 10.1007/s13365-025-01252-z

Kara Rademeyer, Austin M Jones, Emily A Miller, Daniel Conway, Joseph L McClay, Kurt F Hauser, MaryPeace McRae

{"title":"Differential effects of fentanyl compared to morphine on neuroinflammatory signaling in the brain in EcoHIV-infected mice.","authors":"Kara Rademeyer, Austin M Jones, Emily A Miller, Daniel Conway, Joseph L McClay, Kurt F Hauser, MaryPeace McRae","doi":"10.1007/s13365-025-01252-z","DOIUrl":"10.1007/s13365-025-01252-z","url":null,"abstract":"HIV-associated neurocognitive disorders (HAND) pose significant challenges, particularly in individuals with comorbid opioid use disorder (OUD). Fentanyl, a potent synthetic opioid, is a leading contributor to opioid-related fatalities, yet its effects in the context of HIV remain poorly understood. This study investigated the differential impacts of fentanyl and morphine on neuroinflammatory signaling, blood-brain barrier (BBB) integrity, and antiretroviral (ARV) brain accumulation in EcoHIV-infected mice. C57BL/6 mice were assigned to morphine, fentanyl, or saline treatment groups, with or without EcoHIV infection. Tight junction proteins claudin-5 and ZO-1 were measured in striatum and hippocampus via ELISA, while proinflammatory chemokines were analyzed by multiplex assay. In EcoHIV-infected mice, both opioids significantly increased CCL2, CCL4, CCL5, and CCL11 concentrations in the striatum, with fentanyl causing greater increases in CCL2 than morphine. Additionally, fentanyl, but not morphine, significantly decreased CCL3 concentrations in the striatum. Principal component analysis revealed distinct treatment-specific patterns within the striatum, underscoring opioid-specific differences. Tight junction protein expression data demonstrate opioid-specific, sex-specific, and region-specific effects on the key BBB proteins, ZO-1 and claudin-5. Both opioids also reduced ARV brain concentrations in infected mice, with region- and opioid-specific effects. Fentanyl decreased dolutegravir in the hippocampus, while morphine decreased abacavir in both regions. These findings demonstrate that fentanyl and morphine exposure in the context of HIV produce distinct impacts on neuroinflammatory response, BBB integrity, and ARV brain exposure. Understanding these opioid-specific effects is critical for improving clinical outcomes and treatment strategies for individuals with HIV and OUD.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"242-261"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report and mini-review of Crimean-Congo hemorrhagic fever with encephalitis: an unexpected complication. 克里米亚-刚果出血热伴脑炎的病例报告及综述：一种意外并发症。

IF 1.9 4区医学

Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1007/s13365-025-01253-y

Elham Barahimi, Elham Ouspid, Mahyar Hossein-Zargari, Masoumeh Ardeshiri, MohammadHosein Sheybani-Arani

{"title":"A case report and mini-review of Crimean-Congo hemorrhagic fever with encephalitis: an unexpected complication.","authors":"Elham Barahimi, Elham Ouspid, Mahyar Hossein-Zargari, Masoumeh Ardeshiri, MohammadHosein Sheybani-Arani","doi":"10.1007/s13365-025-01253-y","DOIUrl":"10.1007/s13365-025-01253-y","url":null,"abstract":"Crimean-Congo hemorrhagic fever is a severe tick-borne viral infection with high mortality rates. While Crimean-Congo hemorrhagic fever primarily presents as a hemorrhagic fever, central nervous system involvement, including encephalitis, is rare. The virus, transmitted through tick bites or direct contact with infected animal blood or bodily fluids, can lead to multi-organ failure. Neurological manifestations of Crimean-Congo hemorrhagic fever remain poorly understood. We report a 40-year-old man from Hormozgan province, Iran, who presented with fever, hematemesis, abdominal pain, and neurological symptoms. Initial laboratory findings indicated thrombocytopenia and elevated liver enzymes. Despite treatment with ribavirin, the patient developed agitation, confusion, and a progressive decline in consciousness. Brain imaging suggested encephalitis, and cerebrospinal fluid analysis revealed mild pleocytosis with elevated protein levels. Crimean-Congo hemorrhagic fever was confirmed via polymerase chain reaction testing. The patient was treated with ribavirin, intravenous immunoglobulin, and high-dose methylprednisolone, gradually recovering neurological function. Crimean-Congo hemorrhagic fever with encephalitis is an uncommon but severe presentation, necessitating prompt diagnosis and intervention. This case highlights the potential role of corticosteroids and intravenous immunoglobulin in managing Crimean-Congo hemorrhagic fever-associated neurological manifestations. Further studies are needed to establish standardized treatment protocols for Crimean-Congo hemorrhagic fever-related encephalitis.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"197-207"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0