Diagnostic significance of miR-34c-5p in patients with postherpetic neuralgia and its correlation with rehabilitation effect.

IF 1.9 4区 医学 Q3 NEUROSCIENCES
Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI:10.1007/s13365-025-01264-9
Xiaojun Zhou, Huan Ding, Bin Wang, Hui Kang
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Abstract

Background: Postherpetic neuralgia (PHN) represents the most prevalent and distressing complication of shingles. The aim of this study was to explore the diagnostic significance of miR-34c-5p in PHN patients and to assess its correlation with rehabilitation effect.

Methods: This study enrolled 154 PHN patients and 108 healthy participants as research subjects. RT-qPCR was used to detect serum miR-34c-5p levels in the participants. ROC curve was employed to estimate the diagnostic significance of miR-34c-5p in PHN patients. Logistic regression analysis was performed to analyze the risk factors related to the occurrence of PHN. VAS, TEX-Q and HADS scales were filled in by questionnaires to analyze the rehabilitation effect of PHN patients after treatment. Spearman correlation analysis was applied to evaluate the relationship of miR-34c-5p levels with rehabilitation effect in treated PHN patients.

Results: miR-34c-5p levels were notably elevated in PHN patients compared to healthy participants. miR-34c-5 had a high sensitivity (79.2%) and specificity (84.3%) to distinguish between healthy individuals and PHN patients. Logistic regression analysis indicated that miR-34c-5p emerged as an independent risk factor for the development of PHN. miR-34c-5p levels, VAS, TEX-Q, HADS-A and HADS-D scores were reduced in prednisone-treated PHN patients compared to the basic treatment group. In addition, Spearman correlation suggested that miR-34c-5p levels were positively correlated with VAS, TEX-Q, HADS-A and HADS-D scores.

Conclusion: miR-34c-5p exhibited the ability to diagnose PHN and may be a biomarker for diagnosis of this disease. Moreover, reduced miR-34c-5p expression in PHN patients correlate with enhanced outcomes in rehabilitation.

miR-34c-5p在疱疹后神经痛患者中的诊断意义及其与康复效果的相关性。
背景:带状疱疹后神经痛(PHN)是带状疱疹最常见和最痛苦的并发症。本研究旨在探讨miR-34c-5p在PHN患者中的诊断意义,并评估其与康复效果的相关性。方法:本研究招募了154例PHN患者和108名健康受试者作为研究对象。采用RT-qPCR检测受试者血清miR-34c-5p水平。采用ROC曲线估计miR-34c-5p在PHN患者中的诊断意义。采用Logistic回归分析与PHN发生相关的危险因素。采用问卷方式填写VAS、TEX-Q、HADS量表,分析PHN患者治疗后的康复效果。采用Spearman相关分析评价治疗后PHN患者miR-34c-5p水平与康复效果的关系。结果:与健康参与者相比,PHN患者的miR-34c-5p水平显著升高。miR-34c-5在区分健康个体和PHN患者方面具有很高的敏感性(79.2%)和特异性(84.3%)。Logistic回归分析显示miR-34c-5p是PHN发生的独立危险因素。与基础治疗组相比,泼尼松治疗的PHN患者miR-34c-5p水平、VAS、TEX-Q、HADS-A和HADS-D评分均降低。此外,Spearman相关提示miR-34c-5p水平与VAS、TEX-Q、HADS-A、HADS-D评分呈正相关。结论:miR-34c-5p具有诊断PHN的能力,可能是诊断该病的生物标志物。此外,PHN患者miR-34c-5p表达降低与康复预后增强相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
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