{"title":"Diagnostic significance of miR-34c-5p in patients with postherpetic neuralgia and its correlation with rehabilitation effect.","authors":"Xiaojun Zhou, Huan Ding, Bin Wang, Hui Kang","doi":"10.1007/s13365-025-01264-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Postherpetic neuralgia (PHN) represents the most prevalent and distressing complication of shingles. The aim of this study was to explore the diagnostic significance of miR-34c-5p in PHN patients and to assess its correlation with rehabilitation effect.</p><p><strong>Methods: </strong>This study enrolled 154 PHN patients and 108 healthy participants as research subjects. RT-qPCR was used to detect serum miR-34c-5p levels in the participants. ROC curve was employed to estimate the diagnostic significance of miR-34c-5p in PHN patients. Logistic regression analysis was performed to analyze the risk factors related to the occurrence of PHN. VAS, TEX-Q and HADS scales were filled in by questionnaires to analyze the rehabilitation effect of PHN patients after treatment. Spearman correlation analysis was applied to evaluate the relationship of miR-34c-5p levels with rehabilitation effect in treated PHN patients.</p><p><strong>Results: </strong>miR-34c-5p levels were notably elevated in PHN patients compared to healthy participants. miR-34c-5 had a high sensitivity (79.2%) and specificity (84.3%) to distinguish between healthy individuals and PHN patients. Logistic regression analysis indicated that miR-34c-5p emerged as an independent risk factor for the development of PHN. miR-34c-5p levels, VAS, TEX-Q, HADS-A and HADS-D scores were reduced in prednisone-treated PHN patients compared to the basic treatment group. In addition, Spearman correlation suggested that miR-34c-5p levels were positively correlated with VAS, TEX-Q, HADS-A and HADS-D scores.</p><p><strong>Conclusion: </strong>miR-34c-5p exhibited the ability to diagnose PHN and may be a biomarker for diagnosis of this disease. Moreover, reduced miR-34c-5p expression in PHN patients correlate with enhanced outcomes in rehabilitation.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"295-301"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of NeuroVirology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13365-025-01264-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/3 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Postherpetic neuralgia (PHN) represents the most prevalent and distressing complication of shingles. The aim of this study was to explore the diagnostic significance of miR-34c-5p in PHN patients and to assess its correlation with rehabilitation effect.
Methods: This study enrolled 154 PHN patients and 108 healthy participants as research subjects. RT-qPCR was used to detect serum miR-34c-5p levels in the participants. ROC curve was employed to estimate the diagnostic significance of miR-34c-5p in PHN patients. Logistic regression analysis was performed to analyze the risk factors related to the occurrence of PHN. VAS, TEX-Q and HADS scales were filled in by questionnaires to analyze the rehabilitation effect of PHN patients after treatment. Spearman correlation analysis was applied to evaluate the relationship of miR-34c-5p levels with rehabilitation effect in treated PHN patients.
Results: miR-34c-5p levels were notably elevated in PHN patients compared to healthy participants. miR-34c-5 had a high sensitivity (79.2%) and specificity (84.3%) to distinguish between healthy individuals and PHN patients. Logistic regression analysis indicated that miR-34c-5p emerged as an independent risk factor for the development of PHN. miR-34c-5p levels, VAS, TEX-Q, HADS-A and HADS-D scores were reduced in prednisone-treated PHN patients compared to the basic treatment group. In addition, Spearman correlation suggested that miR-34c-5p levels were positively correlated with VAS, TEX-Q, HADS-A and HADS-D scores.
Conclusion: miR-34c-5p exhibited the ability to diagnose PHN and may be a biomarker for diagnosis of this disease. Moreover, reduced miR-34c-5p expression in PHN patients correlate with enhanced outcomes in rehabilitation.
期刊介绍:
The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects.
The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.