Journal of NeuroVirology最新文献_第10页

Bidirectional relationship between human herpes virus reactivation and depression: a systematic review and meta-analysis. 人类疱疹病毒再激活与抑郁症的双向关系：一项系统综述和荟萃分析。

IF 2 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-03-26 DOI: 10.1007/s13365-025-01246-x

Arman Shafiee, Zahra Nakhaee, Mohammad Javad Amini, Fatemeh Esmailpur Abianeh, Mana Goodarzi, Samira Parvizi Omran, Hamed Hajishah, Dina Sadeghi, Aida Rezaei Nejad, Mahmood Bakhtiyari

{"title":"Bidirectional relationship between human herpes virus reactivation and depression: a systematic review and meta-analysis.","authors":"Arman Shafiee, Zahra Nakhaee, Mohammad Javad Amini, Fatemeh Esmailpur Abianeh, Mana Goodarzi, Samira Parvizi Omran, Hamed Hajishah, Dina Sadeghi, Aida Rezaei Nejad, Mahmood Bakhtiyari","doi":"10.1007/s13365-025-01246-x","DOIUrl":"10.1007/s13365-025-01246-x","url":null,"abstract":"Background: Human herpesviruses (HHVs) are lifelong pathogens that can reactivate under stress or immunological changes. Depression has been implicated as both a potential trigger for and a consequence of HHV reactivation. This study investigates the bidirectional relationship between HHV reactivation and depression through a systematic review and meta-analysis.Methods: This systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD42024565616). A search of PubMed, Web of Science, Embase, and Scopus identified studies published through March 5, 2024.Results: Nineteen studies, representing a total sample size of 94,194 participants, were included in the meta-analysis. The pooled odds ratio (OR) demonstrated a significant association between HHV reactivation and depression (OR = 1.33; 95% CI: 1.07-1.64; p < 0.001; I2 = 92%). Subgroup analyses revealed significant associations for Epstein-Barr virus (EBV) (OR = 1.99; 95% CI: 1.80-2.20) and herpes simplex virus 2 (HSV-2) (OR = 1.83; 95% CI: 1.32-2.55), while cytomegalovirus (CMV) and HSV-1 showed non-significant associations. A secondary meta-analysis found a significant association between pre-morbid depression and EBV reactivation (OR = 2.18; 95% CI: 1.48-3.21) as well as varicella-zoster virus (VZV) reactivation (HR = 1.09; 95% CI: 1.06-1.13). Sensitivity analyses confirmed the robustness of the findings, and no substantial publication bias was detected.Conclusion: This study provides evidence of a bidirectional relationship between HHV reactivation and depression, highlighting depression as both a risk factor for and a potential consequence of HHV reactivation.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"145-153"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maintaining the battle against vaccine-preventable neurological diseases in the United States. 在美国继续与疫苗可预防的神经系统疾病作斗争。

IF 2 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-04-22 DOI: 10.1007/s13365-025-01256-9

Farrah J Mateen

引用次数: 0

The OLR1/NF-κB feedback loop exacerbates HIV-1 Tat-induced microglial inflammatory response and neuronal apoptosis. OLR1/NF-κB反馈回路加剧了HIV-1 tat诱导的小胶质细胞炎症反应和神经元凋亡。

IF 2 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-03-26 DOI: 10.1007/s13365-025-01249-8

Qifei Zhang, Wenhua Tao, Jing Wang, Meijuan Qian, Mingming Zhou, Lin Gao

{"title":"The OLR1/NF-κB feedback loop exacerbates HIV-1 Tat-induced microglial inflammatory response and neuronal apoptosis.","authors":"Qifei Zhang, Wenhua Tao, Jing Wang, Meijuan Qian, Mingming Zhou, Lin Gao","doi":"10.1007/s13365-025-01249-8","DOIUrl":"10.1007/s13365-025-01249-8","url":null,"abstract":"Oxidized low density lipoprotein receptor 1 (OLR1), a type II integral membrane glycoprotein, is involved in multiple neurological diseases. However, the roles and mechanisms of OLR1 in HIV-associated neurocognitive disorder (HAND) remain unclear. In the central nervous system, Transactivator of transcription (Tat) induces inflammatory response in microglia, thereby leading to neuronal apoptosis. In the present study, we demonstrated that OLR1 expression was upregulated during ectopic expression of Tat or soluble Tat stimulus in BV-2 microglial cells. Moreover, OLR1 signaling was proved to facilitate Tat-triggered inflammatory response and alleviated the microglia-derived conditioned media-mediated HT-22 neural cells apoptosis in a NF-κB-dependent manner. Conversely, Tat augmented OLR1 expression via NF-κB signaling pathway. Finally, in mouse models, we determined that silencing of OLR1 significantly ameliorated Tat‑induced neuroinflammation and hippocampal neuronal death. Taken together, our study clarifies the potential role of the OLR1/NF-κB feedback loop in Tat-induced microglial inflammatory response and neuronal apoptosis, which could be a novel therapeutic target for relief of HAND.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"170-186"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Progressive multifocal leukoencephalopathy during 4 years of Palbociclib for advanced breast cancer with a history of follicular lymphoma patient. 更正：有滤泡性淋巴瘤病史的晚期乳腺癌患者在帕博西尼治疗4年期间出现进行性多灶性脑白质病变。

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 DOI: 10.1007/s13365-025-01259-6

Mariko Nishihara, Ryosuke Koyamada, Tetsuhiro Masaki, Tomohito Shimada, Kazuhiro Ishikawa, Jun Hashimoto, Nobuyoshi Mori, Asami Namai, Hideaki Yokoo, Kenta Takahashi, Tadaki Suzuki, Kazuo Nakamichi, Shinichiro Mori

引用次数: 0

In vitro characterization of the antiviral activity of Bat Interferon-Induced protein with tetratricopeptide repeats 5 (bat IFIT5) against bat-associated rabies virus. 蝙蝠干扰素诱导蛋白与四肽重复5 （Bat IFIT5）对蝙蝠相关狂犬病毒抗病毒活性的体外鉴定

IF 2 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1007/s13365-025-01245-y

Camila Mosca Barboza, Raphaela Mello Zamudio, Ana Claudia Franco, Helena Beatriz de Carvalho Ruthner Batista

{"title":"In vitro characterization of the antiviral activity of Bat Interferon-Induced protein with tetratricopeptide repeats 5 (bat IFIT5) against bat-associated rabies virus.","authors":"Camila Mosca Barboza, Raphaela Mello Zamudio, Ana Claudia Franco, Helena Beatriz de Carvalho Ruthner Batista","doi":"10.1007/s13365-025-01245-y","DOIUrl":"10.1007/s13365-025-01245-y","url":null,"abstract":"Bats are important reservoirs of zoonotic viruses, including the rabies virus (RABV), which causes rabies, a significant and fatal disease. In Brazil, RABV has been detected in several bat species. Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5) is part of a group of interferon-stimulated genes (ISGs) known for their antiviral activity. This study investigated the interaction between batIFIT5 and different genetic lineages of RABV. The batIFIT5 was expressed in HEK-293T cells, which were infected with RABV genetic lineages isolated from Eptesicus furinalis (IP 964/06) and Tadarida brasiliensis (IP 3214/19), at varying infectious doses (pure, 100, 10, and 1). Direct immunofluorescence was performed to assess the effect of batIFIT5 on virus replication through the counting of fluorescent foci. Subsequently, after the expression of batIFIT5, 1 MOI was selected and used to evaluate the potential antiviral effect. Immunofluorescence was performed 24 and 48 h after infection. As a result, the viral concentration remained similar in the presence of batIFIT5 across distinct infectious doses. After infection with 1 MOI, a 30% reduction in infection rates was observed, particularly for the IP 3214/19 isolate after 24 h. These results highlight the potential antiviral role of IFIT5 against RABV infection.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"163-169"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing cognitive impairment in HIV-infected: a comparative study of international HIV Dementia Scale, HIV Dementia Scale Italian version and Montreal cognitive assessment in clinical practice. 评估HIV感染者的认知障碍：国际HIV痴呆量表、意大利版HIV痴呆量表和蒙特利尔认知评估在临床实践中的比较研究

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1007/s13365-025-01248-9

Maristella Belfiori, Francesco Salis, Camilla Podda, Lorenzo Stanisci, Benedetta Puxeddu, Francesco Ortu, Paola Piano, Stefano Del Giacco, Antonella Mandas

{"title":"Assessing cognitive impairment in HIV-infected: a comparative study of international HIV Dementia Scale, HIV Dementia Scale Italian version and Montreal cognitive assessment in clinical practice.","authors":"Maristella Belfiori, Francesco Salis, Camilla Podda, Lorenzo Stanisci, Benedetta Puxeddu, Francesco Ortu, Paola Piano, Stefano Del Giacco, Antonella Mandas","doi":"10.1007/s13365-025-01248-9","DOIUrl":"10.1007/s13365-025-01248-9","url":null,"abstract":"The combination of antiretroviral therapy (cART) and preventive measures has significantly enhanced the management of Human Immunodeficiency Virus (HIV) infection. However, HIV-associated neurocognitive disorders (HAND) remain a challenge. This study aims to compare cognitive impairment (CI) assessments in people living with HIV/AIDS (PLWHA) using the International HIV Dementia Scale (IHDS), HIV Dementia Scale-Italian Version (HDS-IT) and MoCA (Montreal Cognitive Assessment), while also identifying significant associations. The cross-sectional study encompassed 294 outpatient PLWHA (median age: 57) on cART. Participants underwent cognitive, functional, and depression assessments, laboratory testing and CNS Penetration-Effectiveness (CPE) index assessment. IHDS, HDS-IT and MoCA identified CI in different proportions of PLWHA. Factors such as age, education level, infection duration, and substance use were associated with CI. The IHDS score (OR 0.79) and Level CD4 + T-lymphocytes nadir (OR 0.99) demonstrated independent and negative associations with the CPE-index. IHDS and MoCA tests appear to be useful for detecting CI in outpatient settings, enabling healthcare providers to conduct initial evaluations of PLWHA. IHDS assessment may be used for detecting CI related to high CPE regimens, while the MoCA provides a comprehensive assessment, also in domains not studied by IHDS. However, further research is needed to confirm these findings and refine their clinical applicability.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"131-144"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the impact of simulated microgravity on HSV-1 infection, neuroinflammation, and endogenous retroviral activation in SH-SY5Y cells. 揭示模拟微重力对HSV-1感染、神经炎症和SH-SY5Y细胞内源性逆转录病毒激活的影响。

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.1007/s13365-025-01251-0

Seyedesomaye Jasemi, Elena Rita Simula, Kawaguchi Yasushi, Leonardo Antonio Sechi

{"title":"Unveiling the impact of simulated microgravity on HSV-1 infection, neuroinflammation, and endogenous retroviral activation in SH-SY5Y cells.","authors":"Seyedesomaye Jasemi, Elena Rita Simula, Kawaguchi Yasushi, Leonardo Antonio Sechi","doi":"10.1007/s13365-025-01251-0","DOIUrl":"10.1007/s13365-025-01251-0","url":null,"abstract":"Microgravity (µg) during spaceflight affects cellular and molecular functions of both human cells and microbial pathogens, influencing viral replication and the host immune system. This study aimed to investigate the effects of simulated µg on Herpes Simplex Virus-1 (HSV-1) replication, host pro-inflammatory cytokine, and human endogenous retrovirus (HERV) activation in human neuroblastoma SH-SY5Y cells. Our results show that µg has a negative impact on HSV-1 replication, leading to significantly reduced viral titers and lower expression levels of HSV-1 early genes (ICP0, ICP4, and ICP27) compared to 1 gravity (1 g) conditions. Interestingly, despite lower viral titers and HSV-1 gene expressions under µg condition, we observed higher levels of HERVs and pro-inflammatory cytokine gene expression. In addition, there was a significant correlation between HSV-1 immediate-early genes with HERVs and pro-inflammatory cytokine gene expression, with stronger correlations observed under µg conditions. Taken together, µg reduces HSV-1 replication and increases host pro-inflammatory and HERVs gene expression, which demands further investigation for human health protection in space.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"154-162"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive multifocal leukoencephalopathy during 4 years of Palbociclib for advanced breast cancer with a history of follicular lymphoma patient. 4年帕博西尼治疗晚期乳腺癌伴滤泡性淋巴瘤患者进展性多灶性脑白质病

IF 2.3 4区医学

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-04-21 DOI: 10.1007/s13365-025-01255-w

Ryosuke Koyamada, Mariko Nishihara, Tetsuhiro Masaki, Tomohito Shimada, Kazuhiro Ishikawa, Jun Hashimoto, Nobuyoshi Mori, Asami Namai, Hideaki Yokoo, Kenta Takahashi, Tadaki Suzuki, Kazuo Nakamichi, Shinichiro Mori

引用次数: 0

SARS-CoV-2: A synergy to the Alzheimer's disease. SARS-CoV-2：与阿尔茨海默病的协同作用

IF 2 4区医学

Journal of NeuroVirology Pub Date : 2025-02-01 Epub Date: 2025-02-25 DOI: 10.1007/s13365-025-01247-w

Khaja Moinuddin Shaik, Deepak Kumar, Pirangi Srikanth, Sukhendu Nandi

{"title":"SARS-CoV-2: A synergy to the Alzheimer's disease.","authors":"Khaja Moinuddin Shaik, Deepak Kumar, Pirangi Srikanth, Sukhendu Nandi","doi":"10.1007/s13365-025-01247-w","DOIUrl":"10.1007/s13365-025-01247-w","url":null,"abstract":"COVID-19 was a nightmare in humankind's history that challenged our advanced medical technology. All credit goes to the researchers who played a crucial role in curbing COVID-19 and proved our medical technology supremacy. However, COVID-19 has left some mysterious scars on human well-being. It is believed that COVID-19 has a significant negative impact on various cardiovascular (CVS) and central nervous system (CNS) diseases, especially in the case of CNS diseases like Alzheimer's. Surprisingly, COVID-19 affects the respiratory system, whereas Alzheimer's disease (AD) alters brain function. To explain this phenomenon, several hypotheses were proposed, but the mechanism needs to be clearly understood. Another critical thing to be concerned about is that COVID-19 will worsen pre-existing conditions and lead to the onset of AD. In the race to curb COVID-19, the invention of vaccines was speeded up, and it is necessary to fight against COVID-19. However, postvaccination follow-up is mandatory when an individual is a victim of AD. In this review article, we compiled the various dreadful effects of the COVID-19 virus on AD, the Post effects of the virus on AD, and the effect of the COVID-19 vaccination on AD. This article provides a new direction for research concerning COVID-19 and AD.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"16-23"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generating fair, reliable, and accurate neuropsychological test norms for people with HIV in a low- or middle-income country. 为低收入或中等收入国家的艾滋病毒感染者制定公平、可靠和准确的神经心理学测试规范。

IF 2 4区医学

Journal of NeuroVirology Pub Date : 2025-02-01 Epub Date: 2024-12-30 DOI: 10.1007/s13365-024-01235-6

H Gouse, K G F Thomas, C J Masson, M Henry, J A Joska, L A Cysique, S Ling, X Ye, J Liu, R N Robbins

{"title":"Generating fair, reliable, and accurate neuropsychological test norms for people with HIV in a low- or middle-income country.","authors":"H Gouse, K G F Thomas, C J Masson, M Henry, J A Joska, L A Cysique, S Ling, X Ye, J Liu, R N Robbins","doi":"10.1007/s13365-024-01235-6","DOIUrl":"10.1007/s13365-024-01235-6","url":null,"abstract":"Effective neuropsychological assessment of people with HIV (PWH) in low- and middle-income countries (LMICs) is hampered by the unavailability of adequate test norms. We aimed to: (1) develop demographically-corrected (regression-based) South African (SA) normative data for an HIV appropriate neuropsychological test battery for Xhosa home-language speakers; (2) compare the utility of those norms to that of (i) internal standardization norms and (ii) US test publisher norms; and (3) determine the criterion validity of the newly-developed norms. 114 controls and 102 demographically comparable Xhosa home-language people living with HIV completed a well-establised, standard HIV neuropsychological test battery assessing seven cognitive domains. Using a common performance metric (z-score), we compared control and PWH test performance and examined the extent to which the three different normative datasets embedded demographic effects e.g., education. Using internal standardization norms, analyses detected medium-sized correlations of overall test performance with age and education. Correlations were fully corrected for by the newly-developed demographically-corrected norms. Using demographically-corrected norms, PWH performed significantly more poorly than controls in five cognitive domains, whereas using internal standardization norms and test-publisher norms, PWH performed significantly more poorly than controls in one and two domains, respectively. Demographically-corrected norms estimated 43.1% of PWH were cognitively impaired; these estimates were 22.5% using test-publisher norms and 19.6% using internal standardization norms. Demographically-corrected SA norms were more sensitive to cognitive impairment in PWH than the other sets of norms. Expansion of this regression-based method to create population-appropriate norms will benefit research and clinical practice in LMICs.","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"41-55"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0