Neuropsychiatric disorders in the course to SARS-CoV-2 virus infection, including biological pathomechanisms, psychosocial factors and long COVID-19 associated with "brain fog".

IF 1.9 4区 医学 Q3 NEUROSCIENCES
Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-04-07 DOI:10.1007/s13365-025-01242-1
Jakub Sadowski, Samanta Anna Ostrowska, Tomasz Klaudel, Monika Zaborska, Maksymilian Chruszcz, Anna Sztangreciak-Lehun, Rafał Jakub Bułdak
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引用次数: 0

Abstract

During the COVID-19 pandemic, neuropsychiatric disorders began to be observed in a significant proportion of patients, occurring at different times after infection and characterised by varying degrees of severity. This article discusses neurological and psychiatric disorders associated with SARS-CoV-2 virus infection, taking into account biological pathomechanisms and psychosocial factors. The long COVID-19 along with the "brain fog" phenomenon were considered in the study. The purpose of the study is to analyse and discuss the available information from the scientific literature on the possible association between SARS-CoV-2 virus infection and the occurrence of neuropsychiatric disorders with different degrees of severity and temporal correlation. To discuss the correlation of COVID-19 with the occurrence of neuropsychiatric disorders, a systematic literature review was conducted using the following databases: PubMed, Elsevier and Google Scholar. The following keywords were used when searching the materials used: "neuropsychiatric disorders", "COVID-19", "SARS-CoV-2", "NeuroCOVID", "cytokine storm" and "long COVID-19". Focusing on the characteristics of the materials and methods used, as well as the results obtained and conclusions reached in each article, 164 publications of research, meta-analysis, review and case reports were included in the study. Neuropsychiatric disorders resulting from SARS-CoV-2 virus infection are multifactorial in nature. The main elements responsible for the varied pattern of symptoms include direct and indirect central nervous system effects of the disease, individual patient conditions, psychosocial factors, severity of immune responses and severity of infection. The neuropsychiatric effects of SARS-CoV-2 infection can be divided into symptoms directly related to the neurological and psychiatric zones and mixed disorders.

神经精神障碍在SARS-CoV-2病毒感染过程中,包括生物病理机制、社会心理因素和长期与COVID-19相关的“脑雾”。
在2019冠状病毒病大流行期间,相当比例的患者开始出现神经精神障碍,这些障碍发生在感染后的不同时间,并且具有不同程度的严重程度。本文讨论了与SARS-CoV-2病毒感染相关的神经和精神疾病,并考虑了生物病理机制和社会心理因素。研究中考虑了长时间的新冠肺炎和“脑雾”现象。本研究的目的是分析和讨论从科学文献中获得的关于SARS-CoV-2病毒感染与不同严重程度的神经精神障碍的发生之间可能存在的关联和时间相关性的现有信息。为了探讨COVID-19与神经精神疾病发生的相关性,我们使用PubMed、Elsevier和谷歌Scholar数据库进行了系统的文献综述。检索所用资料时使用的关键词为:“神经精神障碍”、“COVID-19”、“SARS-CoV-2”、“NeuroCOVID”、“细胞因子风暴”和“长COVID-19”。根据所用材料和方法的特点,以及每篇文章所获得的结果和得出的结论,本研究纳入了164篇研究、荟萃分析、综述和病例报告。由SARS-CoV-2病毒感染引起的神经精神障碍是多因素的。造成各种症状模式的主要因素包括疾病对中枢神经系统的直接和间接影响、患者个体状况、社会心理因素、免疫反应的严重程度和感染的严重程度。SARS-CoV-2感染的神经精神效应可分为与神经和精神区直接相关的症状和混合性障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
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