Bidirectional relationship between human herpes virus reactivation and depression: a systematic review and meta-analysis.

IF 1.9 4区 医学 Q3 NEUROSCIENCES
Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-03-26 DOI:10.1007/s13365-025-01246-x
Arman Shafiee, Zahra Nakhaee, Mohammad Javad Amini, Fatemeh Esmailpur Abianeh, Mana Goodarzi, Samira Parvizi Omran, Hamed Hajishah, Dina Sadeghi, Aida Rezaei Nejad, Mahmood Bakhtiyari
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引用次数: 0

Abstract

Background: Human herpesviruses (HHVs) are lifelong pathogens that can reactivate under stress or immunological changes. Depression has been implicated as both a potential trigger for and a consequence of HHV reactivation. This study investigates the bidirectional relationship between HHV reactivation and depression through a systematic review and meta-analysis.

Methods: This systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD42024565616). A search of PubMed, Web of Science, Embase, and Scopus identified studies published through March 5, 2024.

Results: Nineteen studies, representing a total sample size of 94,194 participants, were included in the meta-analysis. The pooled odds ratio (OR) demonstrated a significant association between HHV reactivation and depression (OR = 1.33; 95% CI: 1.07-1.64; p < 0.001; I2 = 92%). Subgroup analyses revealed significant associations for Epstein-Barr virus (EBV) (OR = 1.99; 95% CI: 1.80-2.20) and herpes simplex virus 2 (HSV-2) (OR = 1.83; 95% CI: 1.32-2.55), while cytomegalovirus (CMV) and HSV-1 showed non-significant associations. A secondary meta-analysis found a significant association between pre-morbid depression and EBV reactivation (OR = 2.18; 95% CI: 1.48-3.21) as well as varicella-zoster virus (VZV) reactivation (HR = 1.09; 95% CI: 1.06-1.13). Sensitivity analyses confirmed the robustness of the findings, and no substantial publication bias was detected.

Conclusion: This study provides evidence of a bidirectional relationship between HHV reactivation and depression, highlighting depression as both a risk factor for and a potential consequence of HHV reactivation.

人类疱疹病毒再激活与抑郁症的双向关系:一项系统综述和荟萃分析。
背景:人类疱疹病毒(hhv)是终身病原体,可在应激或免疫变化下重新激活。抑郁症被认为是HHV再激活的潜在触发因素和结果。本研究通过系统回顾和荟萃分析探讨了HHV再激活与抑郁症之间的双向关系。方法:该系统评价和荟萃分析遵循PRISMA指南,并在PROSPERO注册(CRD42024565616)。通过PubMed、Web of Science、Embase和Scopus的搜索,确定了2024年3月5日之前发表的研究。结果:19项研究,代表94,194名参与者的总样本量,被纳入meta分析。合并优势比(OR)显示HHV再激活与抑郁之间存在显著关联(OR = 1.33;95% ci: 1.07-1.64;p 2 = 92%)。亚组分析显示Epstein-Barr病毒(EBV)与感染有显著相关性(OR = 1.99;95% CI: 1.80-2.20)和单纯疱疹病毒2 (HSV-2) (OR = 1.83;95% CI: 1.32-2.55),而巨细胞病毒(CMV)和HSV-1无显著相关性。一项二级荟萃分析发现,发病前抑郁与EBV再激活之间存在显著关联(OR = 2.18;95% CI: 1.48-3.21)以及水痘-带状疱疹病毒(VZV)再激活(HR = 1.09;95% ci: 1.06-1.13)。敏感性分析证实了研究结果的稳健性,没有发现实质性的发表偏倚。结论:本研究提供了HHV再激活与抑郁之间双向关系的证据,强调抑郁既是HHV再激活的危险因素,也是潜在的后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
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