Progressive multifocal leukoencephalopathy during 4 years of Palbociclib for advanced breast cancer with a history of follicular lymphoma patient.

IF 1.9 4区医学 Q3 NEUROSCIENCES

Journal of NeuroVirology Pub Date : 2025-04-01 Epub Date: 2025-04-21 DOI:10.1007/s13365-025-01255-w

Ryosuke Koyamada, Mariko Nishihara, Tetsuhiro Masaki, Tomohito Shimada, Kazuhiro Ishikawa, Jun Hashimoto, Nobuyoshi Mori, Asami Namai, Hideaki Yokoo, Kenta Takahashi, Tadaki Suzuki, Kazuo Nakamichi, Shinichiro Mori

引用次数: 0

Abstract

A 67-year-old woman with a history of follicular lymphoma and recurrent breast cancer with multiple metastasis developed PML during receiving fluvestrant plus palbociclib. Rituximab and bendamustine had finished 6.5 years ago. Discontinuing palbociclib and using mirtazapine, she is alive a year after diagnosis of PML. It is rare for PML to be diagnosed long after the last dose of rituximab and bendamustine. We will discuss the possible involvement of palbociclib in the course of PML.

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4年帕博西尼治疗晚期乳腺癌伴滤泡性淋巴瘤患者进展性多灶性脑白质病

一名67岁女性，有滤泡性淋巴瘤和复发性乳腺癌合并多发性转移病史，在接受氟维司坦联合帕博西尼治疗期间发生PML。利妥昔单抗和苯达莫司汀在6.5年前结束治疗。停用帕博西尼并使用米氮平，她在诊断为PML后存活了一年。在最后一次服用利妥昔单抗和苯达莫司汀后很长时间才诊断出PML是罕见的。我们将讨论帕博西尼在PML过程中的可能参与。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of NeuroVirology 医学-病毒学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.