Association between Guillain-Barré syndrome and SARS-CoV-2 virus infection, including the impact of COVID-19 vaccination in the context of the development and general clinical characteristics of the disease.
Jakub Sadowski, Joanna Huk, Sylwia Otulak, Jesica Zawiło, Tomasz Klaudel, Mateusz Roszak, Dominik Tenczyński, Rafał Jakub Bułdak
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引用次数: 0
Abstract
During the COVID-19 pandemic, a statistically significant increase in the incidence of Guillain-Barré syndrome (GBS) has begun to be observed. This article discusses the impact of immunological processes on structural and functional changes in the peripheral nervous system on the pathogenesis of GBS. The aim of the systematic review is to analyze and discuss available information from the scientific literature regarding a possible clinical relationship between SARS-CoV-2 infection along with vaccination mainly, adenovector and mRNA vaccines and the development of different types of Guillain-Barré syndrome. The review specifically discusses the role of proinflammatory cytokines and "cytokine storm" in patients with COVID-19 and their potential impact on the phenomenon of "molecular mimicry" and the generation of autoantibodies in GBS. This issue has been expanded to include information from studies on the impact of vaccination against SARS-CoV-2 virus and the higher number of observed cases of Guillain-Barré syndrome. Focusing on the characteristics of the methods, materials, results and conclusions, the review finally included 114 publications, like studies, meta-analyses, clinical cases and reviews. The systematic review was conducted using PubMed, Google Scholar, and Elsevier databases. It pointed out the molecular and clinical association between SARS-CoV-2 virus infections and COVID-19 vaccination, in the development of Guillain-Barré syndrome in the context of its clinical course.
期刊介绍:
The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects.
The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.